MCID: HPT066
MIFTS: 25

Hepatoportal Sclerosis malady

Liver category

Summaries for Hepatoportal Sclerosis

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33MalaCards
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MalaCards: Hepatoportal Sclerosis, also known as obliterative portal venopathy, is related to portal hypertension and protein c deficiency. An important gene associated with Hepatoportal Sclerosis is ELN (elastin). The compounds ang ii and losartan have been mentioned in the context of this disorder. Affiliated tissues include liver and endothelial.

Aliases & Classifications for Hepatoportal Sclerosis

Sources:
49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver


Characteristics (Orphanet epidemiological data):

49
obliterative portal venopathy:
Age of onset: Variable


Aliases & Descriptions:

hepatoportal sclerosis 49
obliterative portal venopathy 49


External Ids:

ICD10 via Orphanet26 K74.1

Related Diseases for Hepatoportal Sclerosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Hepatoportal Sclerosis:



Diseases related to hepatoportal sclerosis

Clinical Features for Hepatoportal Sclerosis

Drugs & Therapeutics for Hepatoportal Sclerosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Hepatoportal Sclerosis

Drug clinical trials:

Search ClinicalTrials for Hepatoportal Sclerosis

Search NIH Clinical Center for Hepatoportal Sclerosis

Search CenterWatch for Hepatoportal Sclerosis

Genetic Tests for Hepatoportal Sclerosis

Anatomical Context for Hepatoportal Sclerosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Hepatoportal Sclerosis:

33
Liver, Endothelial

Animal Models for Hepatoportal Sclerosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Hepatoportal Sclerosis

Sources:
51PubMed
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Articles related to Hepatoportal Sclerosis:

(show all 29)
idTitleAuthorsYear
1
Liver failure and the need for transplantation in 6 patients with hepatoportal sclerosis. (23769069)
2013
2
Hepatoportal sclerosis in childhood: descriptive analysis of 12 patients. (24133357)
2013
3
Hepatoportal sclerosis (obliterative portal venopathy) and nodular regenerative hyperplasia in a patient with myasthenia gravis: A case report and review of the published work. (23675894)
2013
4
Mercaptopurine-induced hepatoportal sclerosis in a patient with Crohn's disease. (22841133)
2013
5
Hepatoportal sclerosis clinical different evolutionary stages: presentation of 3 cases and literature review. (22372805)
2012
6
Induction of elastin expression in vascular endothelial cells relates to hepatoportal sclerosis in idiopathic portal hypertension: possible link to serum anti-endothelial cell antibodies. (22288597)
2012
7
Hepatoportal sclerosis: CT and MRI appearance with histopathologic correlation. (22268180)
2012
8
Oxaliplatin-induced hepatoportal sclerosis, portal hypertension, and variceal bleeding successfully treated with transjugular intrahepatic portosystemic shunt. (22537609)
2012
9
The involvement of nitric oxide in the physiopathology of hepatoportal sclerosis. (22820432)
2012
10
Hepatoportal sclerosis in childhood: some presenting with cholestatic features (a re-evaluation of 12 children). (22150463)
2012
11
Elevated levels of circulating angiotensin converting enzyme in patients with hepatoportal sclerosis. (21290180)
2011
12
Hepatoportal sclerosis and extrahepatic portal venous obstruction associated with anti-phospholipid antibody syndrome in child. (20675717)
2011
13
The development of hepatoportal sclerosis and portal hypertension due to didanosine use in HIV. (21057809)
2011
14
Variceal bleeding in an adolescent with HIV diagnosed with hepatoportal sclerosis and nodular regenerative hyperplasia. (19841596)
2010
15
Liver failure and the need for transplantation in three patients with hepatoportal sclerosis. (19100429)
2008
16
Response to Schiano et al. Hepatoportal sclerosis as a cause of noncirrhotic portal hypertension in patients with HIV. (18341510)
2008
17
Hepatoportal sclerosis: a cause of portal hypertension to bear in mind. (18279649)
2008
18
Hepatoportal sclerosis as a cause of noncirrhotic portal hypertension in patients with HIV. (17640321)
2007
19
Liver failure and need for liver transplantation in patients with advanced hepatoportal sclerosis. (17414109)
2007
20
Clinical features, serum interleukin-6, and interferon-gamma levels of 34 turkish patients with hepatoportal sclerosis. (17404864)
2007
21
Association of Adams-Oliver syndrome and hepatoportal sclerosis: an additional case. (16532468)
2006
22
Adams-Oliver syndrome and hepatoportal sclerosis: occasional association or common mechanism? (15832360)
2005
23
Hepatoportal sclerosis in a child. (15316776)
2004
24
Hepatoportal sclerosis. (8578318)
1995
25
Hepatoportal sclerosis demonstrated by abdominal ultrasonography. (1658085)
1991
26
Hepatoportal sclerosis in childhood. (2421592)
1986
27
Hepatoportal sclerosis in childhood: a mimic of extrahepatic portal vein obstruction. (7252729)
1981
28
Hepatoportal sclerosis--its relationship to intrahepatic portal venous thrombosis. (429020)
1979
29
Extra- and intrahepatic portal hypertension without cirrhosis (hepatoportal sclerosis). (5833586)
1965

Genetic Variations for Hepatoportal Sclerosis

Expression for genes affiliated with Hepatoportal Sclerosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatoportal Sclerosis

Search GEO for disease gene expression data for Hepatoportal Sclerosis.

Pathways for genes affiliated with Hepatoportal Sclerosis

Compounds for genes affiliated with Hepatoportal Sclerosis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Hepatoportal Sclerosis according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1ang ii459.6ACE, ELN
2losartan45 50 29 1112.5ACE, ELN
3diltiazem45 29 1111.4ACE, F2
4amiodarone45 50 29 1112.4ACE, F2
5clopidogrel50 45 11 2412.4F2, ACE
6nifedipine45 50 29 1112.4ELN, ACE
7digoxin45 50 60 11 2413.4ACE, F2
8kininogen459.3F2, ACE
9dermatan sulfate459.3F2, ELN
10polyethylene glycol459.2F2, ELN
11suramin45 29 1111.1ELN, F2
12hyaluronic acid45 2410.0F2, ELN
13n acetylcysteine459.0F2, ELN
14phosphatidylcholine458.9ELN, F2
15aspirin45 50 29 2411.8F2, ACE
16creatinine458.8ELN, F2, ACE

GO Terms for genes affiliated with Hepatoportal Sclerosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Hepatoportal Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5ELN, ACE, F2

Biological processes related to Hepatoportal Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood vessel remodelingGO:0019749.3ELN, ACE

Products for genes affiliated with Hepatoportal Sclerosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatoportal Sclerosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet