MCID: HPT009
MIFTS: 51

Hepatopulmonary Syndrome malady

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Hepatopulmonary Syndrome

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Aliases & Descriptions for Hepatopulmonary Syndrome:

Name: Hepatopulmonary Syndrome 10 47 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:900
ICD1027 K76.81
SNOMED-CT59 371067004
ICD9CM29 573.5
MeSH36 D020065
UMLS65 C0600452

Summaries for Hepatopulmonary Syndrome

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Wikipedia:68 In medicine, hepatopulmonary syndrome is a syndrome of shortness of breath and hypoxemia (low oxygen... more...

MalaCards based summary: Hepatopulmonary Syndrome is related to leishmaniasis and progeria variant syndrome ruvalcaba type, and has symptoms including hepatomegalyand hemoptysis. An important gene associated with Hepatopulmonary Syndrome is ALB (Albumin), and among its related pathways are EGFR Transactivation by Gastrin and Plasma membrane estrogen receptor signaling. Affiliated tissues include liver, lung and endothelial, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Related Diseases for Hepatopulmonary Syndrome

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Diseases related to Hepatopulmonary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis30.2EDNRA, EDNRB
2progeria variant syndrome ruvalcaba type10.7EDN1, NOS3
3kosztolanyi syndrome10.6ALB, EDNRA
4coronary thrombosis10.6EDN1, NOS3
5hyperekplexia 2, autosomal recessive10.6EDN1, EDNRA
6thrombocytopenia10.5EDN1, NOS3
7elastoderma10.5EDN1, VWF
8acute opioid poisoning10.5EDNRA, EDNRB
9acute diffuse nephritis10.5EDN1, EDNRB
10acrodermatitis10.4ALB, EDN1, NOS3
11tinea manuum10.4ALB, TNF
12rheumatic fever10.4EDN1, NOS3
13nephronophthisis familial adult spastic quadriparesis10.4ALB, EDN1, EDNRA
14liver disease10.4
15aortic dissection lentiginosis10.4EDN1, NOS3
16parotitis10.3EDN1, VWF
17chromophobe adenoma10.3EDN1, EDNRA, NOS3
18intermediate dend syndrome10.3EDN1, TNF
19hepatitis10.3
20portal hypertension10.3
21multicentric reticulohistiocytosis10.3ALB, EDN1
22hypersensitivity reaction type iii disease10.2HMOX1, TNF
23liver cirrhosis10.2
24ischemic optic neuropathy10.2NOS3, TNF
25pancreatoblastoma10.2ALB, TNF
26endotheliitis10.2
27hemiplegia alterans10.2NOS3, VEGFA
28heart disease10.2ALB, EDN1, HMOX1, NOS3
29retinitis pigmentosa 7010.2ALB, VEGFA
30right bundle branch block10.1ALB, VEGFA
31moderately severe hemophilia a10.1HMOX1, TNF
32chronic venous leg ulcers10.1NOS3, VEGFA
33microscopic colitis10.1HMOX1, VEGFA
34pulmonary hypertension10.1
35periampullary adenoma10.1EDN1, NOS3, TNF
36obstructive sleep apnea10.1EDN1, NOS3, TNF
37hemifacial spasm10.1ALB, EDNRA, TNF
38microinvasive gastric cancer10.1ALB, VEGFA
39stroke, ischemic10.1AKT1, NOS3, VWF
40band keratopathy10.0ALB, EDN1, TNF
41crohn's disease10.0EDN1, TNF, VWF
42budd-chiari syndrome10.0
43liver leiomyosarcoma10.0ALB, EDNRB, TNF
44senile angioma10.0VEGFA, VWF
45twin-to-twin transfusion syndrome10.0EDN1, EDNRA, EDNRB, NOS3
46biliary atresia10.0
47congenital hepatic fibrosis10.0
48vasomotor rhinitis9.9ALB, HMOX1, VEGFA
49lethal congenital contractural syndrome 29.9EDN1, NOS3, VEGFA
50citrullinemia, adult-onset type ii9.9ALB, NOS3, VEGFA

Graphical network of the top 20 diseases related to Hepatopulmonary Syndrome:



Diseases related to hepatopulmonary syndrome

Symptoms for Hepatopulmonary Syndrome

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UMLS symptoms related to Hepatopulmonary Syndrome:


hepatomegaly, hemoptysis

Drugs & Therapeutics for Hepatopulmonary Syndrome

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Drugs for Hepatopulmonary Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1PolygelinePhase 43
2Liver ExtractsPhase 4, Phase 2, Phase 13572
3
NorfloxacinapprovedPhase 21570458-96-74539
Synonyms:
1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[1-piperazinyl]-3-quinoline- carboxylic acid
1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
68077-27-0
70458-96-7
AC-6855
AC1L1IE1
AKOS000417391
AM 0715
AM 715
AM-0715
AM-715
AM0715
ARONIS24170
BB_SC-0063
BCBcMAP01_000218
BIDD:GT0725
BPBio1_000289
BRD-K11196887-001-05-5
BRN 0567897
BSPBio_000261
BSPBio_002107
Baccidal
Barazan
C06687
C16H18FN3O3
CAS-70458-96-7
CCRIS 6302
CHEBI:100246
CHEMBL9
CID4539
Chibroxin
Chibroxin, MK-366, Baccidal, Sebercim, Zoroxin, Norfloxacin
D00210
D009643
DB01059
DivK1c_000084
EINECS 274-614-4
Fulgram
HMS1568N03
HMS1920B16
HMS2090F03
HMS2091J16
HMS500E06
I14-0947
IDI1_000084
KBio1_000084
KBio2_001497
KBio2_004065
 
KBio2_006633
KBio3_001607
KBioGR_000866
KBioSS_001497
LS-141592
Lexinor
MK 0366
MK 366
MK-0366
MK-366
MK0366
MK366
MLS000069650
Merck Brand of Norfloxacin
MolPort-001-738-625
NCGC00016916-01
NCGC00016916-02
NCGC00021725-03
NCGC00021725-04
NFLX
NINDS_000084
Norflo
Norfloxacin (JP15/USP/INN)
Norfloxacin Merck Brand
Norfloxacin [USAN:BAN:INN:JAN]
Norfloxacine
Norfloxacine [INN-French]
Norfloxacino
Norfloxacino [INN-Spanish]
Norfloxacinum
Norfloxacinum [INN-Latin]
Noroxin
Noroxin (TN)
Oprea1_375152
Prestwick0_000221
Prestwick1_000221
Prestwick2_000221
Prestwick3_000221
Prestwick_633
S1509_Selleck
SMP1_000216
SMR000058200
SPBio_001173
SPBio_002182
SPECTRUM1500440
STK177250
Sebercim
Spectrum2_001017
Spectrum3_000524
Spectrum4_000453
Spectrum5_001154
Spectrum_001017
UNII-N0F8P22L1P
nchembio820-comp2
norfloxacin
4
Sorafenibapproved, investigationalPhase 2671284461-73-0216239, 406563
Synonyms:
284461-73-0
4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate
4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
AB1004622
AC-1674
AC1L50CF
BAX
BAY 43-9006
BAY 43-9006 (free base)
BAY 43-9006 tosylate salt
BAY 439006
BAY 54-9085 (tosylate salt)
BAY-43-0006
BAY-43-9006
BAY-54-9085
BAY43-9006
BRD-K23984367-001-01-8
Bio-0100
CHEBI:47228
CHEBI:50924
CHEMBL1336
CID216239
 
D08524
DB00398
DB07438
EN002709
I06-0856
K00597a
Kinome_766
LS-186067
LS-187021
LS-187788
MolPort-003-850-270
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea
NCGC00167488-01
NSC-724772
NSC747971
Nexavar
STK627350
Sorafenib
Sorafenib (INN)
Sorafenib Tosylate
Sorafenib [INN]
Sorafenib tosylate
Sorafenibum
UNII-9ZOQ3TZI87
ZINC01493878
nchembio.117-comp17
sorafenib
sorafenibum
5
Bosentanapproved, investigationalPhase 2100147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
Bosentanum
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
 
DB00559
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentanum
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
6Topoisomerase InhibitorsPhase 24081
7Cytochrome P-450 Enzyme InhibitorsPhase 23036
8Anti-Infective AgentsPhase 217220
9Cytochrome P-450 CYP1A2 InhibitorsPhase 2460
10Anti-Bacterial AgentsPhase 29140
11Endothelin Receptor AntagonistsPhase 2189
12Antihypertensive AgentsPhase 23618
13Protein Kinase InhibitorsPhase 23162
14cadexomer iodinePhase 2456
15
IodinePhase 24947553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
16
Pentoxifyllineapproved, investigationalPhase 1906493-05-64740
Synonyms:
1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion
1-(5-Oxohexyl)-3,7-dimethylxanthine
1-(5-Oxohexyl)theobromine
2a3c
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl) xantine
3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)xanthine
3,7-Dimethyl-1-(5-oxohexyl)xantine
3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
5-26-14-00081 (Beilstein Handbook Reference)
6493-05-6
AB00052363
AC1L1IUN
AKOS000541484
Agapurin
Agapurin Retard
Azupentat
BAS 00897429
BB_SC-2111
BIDD:GT0174
BL 191
BL-191
BL191
BPBio1_000167
BRD-K57569181-001-05-1
BRN 0558929
BSPBio_000151
BSPBio_003439
C07424
C13H18N4O3
CAS-1677687
CCRIS 6832
CHEMBL628
CID4740
CPD000035998
D00501
D010431
DB00806
Dimethyloxohexylxanthine
DivK1c_000729
Durapental
EHT 0201
EHT-0201
EHT-201
EHT0201
EINECS 229-374-5
EU-0100936
HMS1568H13
HMS1922E16
HMS2051N06
HMS2090H13
HMS2093G21
HMS502E11
Hemovas
I06-1592
IDI1_000729
IN1161
Ikomio
KBio1_000729
KBio2_001924
KBio2_004492
KBio2_007060
KBio3_002942
KBioGR_000893
KBioSS_001924
LS-149385
 
Lopac-P-1784
Lopac0_000936
MLS000079026
MLS000758298
MLS001201764
MolPort-001-823-263
NCGC00015801-01
NCGC00015801-02
NCGC00015801-04
NCGC00015801-10
NCGC00067069-02
NCGC00067069-03
NCGC00067069-04
NCGC00067069-05
NCGC00178062-01
NCGC00178062-02
NINDS_000729
NSC 637086
NSC637086
Oxpentifylline
P 1784
PDSP1_001015
PDSP2_000999
PENTOXYPHYLINE
PNX
Pentoxifilina
Pentoxifilina [INN-Spanish]
Pentoxifyllin
Pentoxifylline
Pentoxifylline (JAN/USP/INN)
Pentoxifylline [USAN:INN:JAN]
Pentoxifyllinum
Pentoxifyllinum [INN-Latin]
Pentoxil
Pentoxil (TN)
Pentoxiphyllin
Pentoxiphylline
Pentoxiphyllium
Pentoxyfylline
Pentoxyphyllin
Pentoxyphylline
Prestwick0_000196
Prestwick1_000196
Prestwick2_000196
Prestwick3_000196
Prestwick_608
Px
Ralofect
Rentylin
SAM001247011
SMR000035998
SPBio_001221
SPBio_002072
SPECTRUM1503611
SR-01000075641-4
STK177321
Spectrum2_001181
Spectrum3_001820
Spectrum4_000227
Spectrum5_001161
Spectrum_001444
Torental
Trental
Trental (TN)
UNII-SD6QCT3TSU
Vasofirin
Vazofirin
ZINC01530776
cis-9-Octadecenoyl coenzyme A
pentoxifylline
17Radiation-Protective AgentsPhase 1333
18Vasodilator AgentsPhase 12926
19Protective AgentsPhase 15651
20Platelet Aggregation InhibitorsPhase 11935
21Phosphodiesterase InhibitorsPhase 11062
22AntioxidantsPhase 12442
23
Rifaximinapproved, investigational9480621-81-46436173
Synonyms:
(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate
4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV
4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin
80621-81-4
88747-56-2
AC-19112
BRN 3584528
Bio-0556
C43H51N3O11
CHEMBL1617
D02554
DB01220
Fatroximin
Flonorm
L 105
L 105 (Ansamacrolide antibiotic)
L 105SV
LS-178059
LS-64147
Lormyx
Lumenax
MLS000759430
Normix
RedActiv
Rifacol
 
Rifamixin
Rifamycin L 105
Rifamycin L 105SV
Rifaxidin
Rifaximin
Rifaximin (USAN/INN)
Rifaximin [USAN:INN]
Rifaximina
Rifaximina [Spanish]
Rifaximine
Rifaximine [French]
Rifaximinum
Rifaximinum [Latin]
Rifaximinun
Rifaxin
Ritacol
S1790_Selleck
SMR000466324
Spiraxin
UNII-L36O5T016N
Xifaxan
Xifaxan, Rifacol, Fatroximin, Rifaximin
Xifaxsan
Xifaxsan (TN)
Zaxine
alpha-0817185
24Gastrointestinal Agents6401
25Nucleic Acid Synthesis Inhibitors3836

Interventional clinical trials:

idNameStatusNCT IDPhase
1Echocardiographic Assessment of Intrapulmonary Vasodilatation: Agitated Saline Versus PolygelineRecruitingNCT00343122Phase 4
2A Pilot Study of Norfloxacin for Hepatopulmonary SyndromeCompletedNCT00362752Phase 2
3Sorafenib for Hepatopulmonary SyndromeRecruitingNCT02021929Phase 2
4Bosentan for Treatment of Hepatopulmonary Syndrome in Patients With Liver CirrhosisRecruitingNCT01518595Phase 2
5Pilot Study of Pentoxifylline for Hepatopulmonary SyndromeTerminatedNCT00593658Phase 1
6Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary SyndromeRecruitingNCT02148536
7Efficacy of Pentoxifylline and Rifaximin Combination in Pentoxifylline Refractory Clinical and Subclinical Hepatopulmonary SyndromeRecruitingNCT01676597

Search NIH Clinical Center for Hepatopulmonary Syndrome


Cochrane evidence based reviews: hepatopulmonary syndrome

Genetic Tests for Hepatopulmonary Syndrome

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Anatomical Context for Hepatopulmonary Syndrome

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MalaCards organs/tissues related to Hepatopulmonary Syndrome:

33
Liver, Lung, Endothelial, Thyroid, Prostate, T cells, Breast

Animal Models for Hepatopulmonary Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Hepatopulmonary Syndrome:

38 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3AKT1, ALB, EDNRB, TNF, VEGFA
2MP:00053678.0ALB, EDN1, EDNRA, EDNRB, HMOX1, NOS3
3MP:00053808.0AKT1, EDN1, EDNRA, EDNRB, TNF, VEGFA
4MP:00028737.8AKT1, ALB, EDN1, EDNRA, NOS3, NR0B2
5MP:00053707.6AKT1, ALB, HMOX1, NOS3, NR0B2, TNF
6MP:00053887.6AKT1, EDNRA, EDNRB, HMOX1, NOS3, TNF
7MP:00053907.2AKT1, EDN1, EDNRA, EDNRB, NOS3, TNF
8MP:00036317.1AKT1, EDN1, EDNRA, EDNRB, NOS3, TNF
9MP:00053816.8ALB, EDN1, EDNRA, EDNRB, NOS3, NR0B2
10MP:00053796.6AKT1, ALB, EDN1, EDNRA, EDNRB, HMOX1
11MP:00053786.4AKT1, EDN1, EDNRA, EDNRB, HMOX1, NOS3
12MP:00053846.3AKT1, ALB, CAV3, EDNRA, EDNRB, HMOX1
13MP:00107686.3AKT1, ALB, EDN1, EDNRA, EDNRB, HMOX1
14MP:00053696.3AKT1, ALB, CAV3, EDN1, EDNRA, EDNRB
15MP:00053876.0AKT1, CAV3, EDNRA, EDNRB, HMOX1, NOS3
16MP:00053855.9AKT1, CAV3, EDN1, EDNRA, EDNRB, HMOX1
17MP:00053765.4AKT1, ALB, CAV3, EDN1, EDNRA, EDNRB

Publications for Hepatopulmonary Syndrome

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Articles related to Hepatopulmonary Syndrome:

(show top 50)    (show all 455)
idTitleAuthorsYear
1
Hepatopulmonary Syndrome and Liver Transplantation: A Recent Review of the Literature. (27047772)
2016
2
Hepatopulmonary Syndrome in Patients With Cystic Fibrosis and Liver Disease. (26867851)
2016
3
Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment. (25627425)
2015
4
Prevalence and impact on survival of hepatopulmonary syndrome and cirrhotic cardiomyopathy in a cohort of cirrhotic patients. (25974637)
2015
5
Variability of Oxygenation in Possible Hepatopulmonary Syndrome: Effects of Requiring Two Abnormal Arterial Blood Gas Results for Diagnosis. (25586084)
2015
6
Aggravation of hepatopulmonary syndrome after sildenafil treatment in a patient with coexisting portopulmonary hypertension. (25653708)
2015
7
Congenital extrahepatic portosystemic shunt: an underdiagnosed but treatable cause of hepatopulmonary syndrome. (26311567)
2015
8
Brain abscess in hepatopulmonary syndrome associated with biliary atresia. (26711920)
2015
9
MiR-206 controls the phenotypic modulation of pulmonary arterial smooth muscle cells induced by serum from rats with hepatopulmonary syndrome by regulating the target gene, annexin A2. (25427750)
2014
10
Successful resolution of very severe hepatopulmonary syndrome following adult-to-adult living donor liver transplantation: Report of two cases. (25355534)
2014
11
Are the spider angiomas skin markers of hepatopulmonary syndrome? (24322187)
2013
12
Pharmacological treatment for hepatopulmonary syndrome. (24102057)
2013
13
Detection of hepatopulmonary syndrome in patients with liver cirrhosis using 3D contrast echocardiography. (22560819)
2012
14
Effects of caffeic acid phenethyl ester (CAPE) on hepatopulmonary syndrome. (21046212)
2011
15
Physiopathological, clinical and therapeutic aspects of hepatopulmonary syndrome. (20589345)
2010
16
Attenuation of experimental hepatopulmonary syndrome in endothelin B receptor-deficient rats. (19196949)
2009
17
Sarcoidosis complicated by cirrhosis and hepatopulmonary syndrome. (18437252)
2008
18
Current concepts in the management of hepatopulmonary syndrome. (19183751)
2008
19
Value of contrast echocardiography for the diagnosis of hepatopulmonary syndrome. (17011830)
2007
20
Successful liver retransplantation for recurrent hepatopulmonary syndrome. (17976130)
2007
21
Hepatopulmonary syndrome. (17722431)
2007
22
Congenital portocaval fistula associated with hepatopulmonary syndrome: ligation vs liver transplantation. (16481229)
2006
23
Liver transplantation of a child with child a cirrhosis and severe hepatopulmonary syndrome. (16797324)
2006
24
Effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome. (16688838)
2006
25
Hepatopulmonary syndrome can show spontaneous resolution: possible mechanism of portopulmonary hypertension overlap? (16423214)
2006
26
Natural history of hepatopulmonary syndrome: Impact of liver transplantation. (15828054)
2005
27
Estrogen promotes intrapulmonary vasodilatation in hepatopulmonary syndrome. (16024287)
2005
28
Congenital absence of portal vein presenting as hepatopulmonary syndrome. (15670231)
2005
29
The hepatopulmonary syndrome: NO way out? (15176675)
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30
Case report of unchanged tacrolimus clearance in a hypoxemic pediatric liver transplant recipient with hepatopulmonary syndrome. (15502939)
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31
Severe polycythemia as the first clinical presentation of hepatopulmonary syndrome. (12811222)
2003
32
Liver transplantation for hepatopulmonary syndrome: a ten-year experience in Paris, France. (12792501)
2003
33
Hepatopulmonary syndrome in noncirrhotic portal hypertensive patients. (12757170)
2003
34
Case 63: hepatopulmonary syndrome. (14519870)
2003
35
Biliary cyst fluid from common bile duct-ligated rats stimulates endothelial nitric oxide synthase in pulmonary artery endothelial cells: a potential role in hepatopulmonary syndrome. (11230754)
2001
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Methylene blue improves the hepatopulmonary syndrome. (11529704)
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Prevalence of hepatopulmonary syndrome in cirrhosis and extrahepatic portal venous obstruction. (11774955)
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Hepatopulmonary syndrome in noncirrhotic portal hypertension. (10836927)
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Hepatopulmonary Syndrome and Liver Transplantation. (10648589)
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Portal hypertension and hepatopulmonary syndrome in a middle-aged man with hepatitis B infection. (11076405)
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Hepatopulmonary syndrome: a prospective study of relationships between severity of liver disease, PaO(2) response to 100% oxygen, and brain uptake after (99m)Tc MAA lung scanning. (10988181)
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Hepatopulmonary syndrome in Gaucher disease with right-to-left shunt: evaluation and measurement using Tc-99m MAA. (10069725)
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Late recurrence and rapid evolution of severe hepatopulmonary syndrome after liver transplantation. (10477847)
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Localizing intrapulmonary shunt in hepatopulmonary syndrome by transesophageal echocardiography. (10506859)
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Pulmonary hypertension following hepatopulmonary syndrome in a patient with cirrhosis. (10453952)
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Hepatopulmonary syndrome associated with sarcoidosis of the liver: case report. (9879271)
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Severe pulmonary hypertension and amelioration of hepatopulmonary syndrome after liver transplantation. (9516572)
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Hepatopulmonary syndrome: the paradigm of liver-induced hypoxaemia. (9395754)
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Elevated exhaled nitric oxide in patients with hepatopulmonary syndrome. (8620957)
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The hepatopulmonary syndrome masquerading as pulmonary Langerhans-cell histiocytosis. Hepatopulmonary Syndrome Study Group. (8198345)
1994

Variations for Hepatopulmonary Syndrome

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Expression for genes affiliated with Hepatopulmonary Syndrome

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Search GEO for disease gene expression data for Hepatopulmonary Syndrome.

Pathways for genes affiliated with Hepatopulmonary Syndrome

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Pathways related to Hepatopulmonary Syndrome according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8EDN1, EDNRA
29.7AKT1, NOS3
39.4EDN1, EDNRA, EDNRB
49.3AKT1, NOS3, VWF
59.1EDN1, EDNRA, EDNRB, NOS3
69.1AKT1, NOS3, TNF
79.1AKT1, EDN1, TNF
89.1AKT1, EDN1, TNF
99.0EDN1, NOS3, VEGFA
10
Show member pathways
9.0AKT1, EDNRA, EDNRB, NOS3
118.9AKT1, EDN1, EDNRA, EDNRB
12
Show member pathways
8.9AKT1, NOS3, VEGFA
13
Show member pathways
8.9AKT1, NOS3, VEGFA
148.9AKT1, NOS3, VEGFA
158.6AKT1, EDN1, HMOX1, VEGFA
168.6AKT1, TNF, VEGFA
178.5AKT1, NOS3, VEGFA, VWF
188.4AKT1, EDNRA, EDNRB, VEGFA
198.3AKT1, EDN1, HMOX1, NOS3, VEGFA
20
Show member pathways
8.3AKT1, NOS3, TNF, VEGFA
21
Show member pathways
8.3AKT1, ALB, NOS3, VEGFA, VWF
22
Show member pathways
8.2AKT1, EDN1, EDNRA, NOS3, VEGFA
238.1AKT1, CAV3, TNF, VEGFA
248.0AKT1, EDN1, NOS3, TNF, VEGFA
25
Show member pathways
7.2AKT1, EDN1, EDNRA, EDNRB, NOS3, TNF

GO Terms for genes affiliated with Hepatopulmonary Syndrome

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Cellular components related to Hepatopulmonary Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:00057839.4ALB, CAV3, HMOX1

Biological processes related to Hepatopulmonary Syndrome according to GeneCards Suite gene sharing:

(show all 48)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by endothelinGO:000310010.6EDN1, NOS3
2histamine secretionGO:000182110.5EDN1, EDNRA
3vein smooth muscle contractionGO:001482610.5EDN1, EDNRB
4endothelin receptor signaling pathwayGO:008610010.5EDNRA, EDNRB
5positive regulation of odontogenesisGO:004248210.4EDN1, EDNRA
6artery smooth muscle contractionGO:001482410.4EDN1, EDNRA
7neural crest cell developmentGO:001403210.4EDN1, EDNRA
8maternal process involved in parturitionGO:006013710.4EDN1, EDNRA
9enteric nervous system developmentGO:004848410.4EDNRA, EDNRB
10respiratory gaseous exchangeGO:000758510.4EDN1, EDNRA
11positive regulation of urine volumeGO:003581010.4EDN1, EDNRB
12response to fluid shear stressGO:003440510.4AKT1, NOS3
13positive regulation of vasodilationGO:004590910.3HMOX1, NOS3
14regulation of nitric-oxide synthase activityGO:005099910.3AKT1, NOS3
15epithelial fluid transportGO:004204510.3EDN1, EDNRB
16nitric oxide biosynthetic processGO:000680910.3AKT1, NOS3
17regulation of epithelial cell proliferationGO:005067810.3EDNRA, EDNRB
18regulation of pHGO:000688510.3EDN1, EDNRB
19positive regulation of renal sodium excretionGO:003581510.2EDN1, EDNRB
20regulation of sensory perception of painGO:005193010.2EDN1, EDNRB
21protein kinase C-activating G-protein coupled receptor signaling pathwayGO:000720510.1EDN1, EDNRA
22nitric oxide metabolic processGO:004620910.1AKT1, NOS3
23negative regulation of cell sizeGO:004579210.1AKT1, CAV3
24vasoconstrictionGO:004231010.0EDN1, EDNRA, EDNRB
25negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.0AKT1, TNF
26intracellular signal transductionGO:00355569.9AKT1, EDN1, HMOX1
27negative regulation of cAMP biosynthetic processGO:00308189.9EDN1, EDNRA
28patterning of blood vesselsGO:00015699.9EDNRA, VEGFA
29glucose transportGO:00157589.9AKT1, EDN1, EDNRA
30positive regulation of blood vessel endothelial cell migrationGO:00435369.7AKT1, VEGFA
31positive regulation of protein complex assemblyGO:00313349.7TNF, VEGFA
32positive regulation of nitric oxide biosynthetic processGO:00454299.7AKT1, EDN1, TNF
33sensory perception of painGO:00192339.6EDN1, EDNRA, EDNRB
34positive regulation of smooth muscle cell proliferationGO:00486619.6EDN1, HMOX1, TNF
35positive regulation of JUN kinase activityGO:00435079.6EDN1, TNF
36response to nicotineGO:00350949.6EDN1, HMOX1
37positive regulation of cytosolic calcium ion concentrationGO:00072049.6CAV3, EDNRA, EDNRB
38positive regulation of angiogenesisGO:00457669.4HMOX1, NOS3, VEGFA
39regulation of blood pressureGO:00082179.3EDN1, EDNRA, EDNRB, HMOX1, NOS3
40platelet activationGO:00301689.2AKT1, ALB, VEGFA
41cellular response to vascular endothelial growth factor stimulusGO:00359249.2AKT1, VEGFA
42in utero embryonic developmentGO:00017019.1EDN1, EDNRA, NOS3, VEGFA
43positive regulation of peptidyl-serine phosphorylationGO:00331389.0AKT1, TNF, VEGFA
44angiogenesisGO:00015259.0HMOX1, NOS3, VEGFA
45negative regulation of apoptotic processGO:00430668.8AKT1, ALB, EDNRA, VEGFA
46cellular response to hypoxiaGO:00714568.6AKT1, EDN1, HMOX1, VEGFA
47positive regulation of protein phosphorylationGO:00019348.6EDNRA, EDNRB, TNF, VEGFA
48negative regulation of transcription from RNA polymerase II promoterGO:00001228.4EDN1, EDNRB, TNF, VEGFA

Sources for Hepatopulmonary Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet