MCID: HPT009
MIFTS: 46

Hepatopulmonary Syndrome malady

Gastrointestinal diseases, Liver diseases categories
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Summaries for Hepatopulmonary Syndrome

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65Wikipedia, 33MalaCards
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Wikipedia:65 In medicine, hepatopulmonary syndrome is a syndrome of shortness of breath and hypoxemia (low oxygen... more...

MalaCards: Hepatopulmonary Syndrome is related to cholestasis and cystic fibrosis. An important gene associated with Hepatopulmonary Syndrome is HMOX1 (heme oxygenase (decycling) 1). The compounds auranofin and Bilirubin have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and endothelial, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Hepatopulmonary Syndrome

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

hepatopulmonary syndrome 8 10 45 62


External Ids:

Disease Ontology8 DOID:900
SNOMED-CT58 371067004
MeSH35 D020065

Related Diseases for Hepatopulmonary Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hepatopulmonary Syndrome:



Diseases related to hepatopulmonary syndrome

Symptoms for Hepatopulmonary Syndrome

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Drugs & Therapeutics for Hepatopulmonary Syndrome

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hepatopulmonary Syndrome

Search NIH Clinical Center for Hepatopulmonary Syndrome

Genetic Tests for Hepatopulmonary Syndrome

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Anatomical Context for Hepatopulmonary Syndrome

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33MalaCards
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MalaCards organs/tissues related to Hepatopulmonary Syndrome:

33
Liver, Lung, Endothelial, Brain, Monocytes, Smooth muscle, Bone marrow, Testes, Bone, Skin

Animal Models for Hepatopulmonary Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hepatopulmonary Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6CAV3, ALB, HMOX1, HTR2B, KCNA5
2MP:00053858.5GDF2, KCNA5, HTR2B, CAV3, HMOX1
3MP:00053708.5HMOX1, BHMT, NR0B2, ALB
4MP:00053767.8CAV3, ALB, NR0B2, BHMT, HMOX1, KCNA5

Publications for Hepatopulmonary Syndrome

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52PubMed
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Articles related to Hepatopulmonary Syndrome:

(show top 50)    (show all 388)
idTitleAuthorsYear
1
Are the spider angiomas skin markers of hepatopulmonary syndrome? (24322187)
2013
2
Pharmacological treatment for hepatopulmonary syndrome. (24102057)
2013
3
Hepatopulmonary syndrome and liver transplantation: who, when, and where? (23471874)
2013
4
Detection of hepatopulmonary syndrome in patients with liver cirrhosis using 3D contrast echocardiography. (22560819)
2012
5
Effects of caffeic acid phenethyl ester (CAPE) on hepatopulmonary syndrome. (21046212)
2011
6
Physiopathological, clinical and therapeutic aspects of hepatopulmonary syndrome. (20589345)
2010
7
Attenuation of experimental hepatopulmonary syndrome in endothelin B receptor-deficient rats. (19196949)
2009
8
Sarcoidosis complicated by cirrhosis and hepatopulmonary syndrome. (18437252)
2008
9
Current concepts in the management of hepatopulmonary syndrome. (19183751)
2008
10
Pentoxifylline therapy for hepatopulmonary syndrome: a pilot study. (18779471)
2008
11
Value of contrast echocardiography for the diagnosis of hepatopulmonary syndrome. (17011830)
2007
12
Successful liver retransplantation for recurrent hepatopulmonary syndrome. (17976130)
2007
13
Hepatopulmonary syndrome. (17722431)
2007
14
Clinical controversies surrounding the diagnosis and treatment of hepatopulmonary syndrome. (17464272)
2007
15
Congenital portocaval fistula associated with hepatopulmonary syndrome: ligation vs liver transplantation. (16481229)
2006
16
Liver transplantation of a child with child a cirrhosis and severe hepatopulmonary syndrome. (16797324)
2006
17
Effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome. (16688838)
2006
18
Hepatopulmonary syndrome can show spontaneous resolution: possible mechanism of portopulmonary hypertension overlap? (16423214)
2006
19
Natural history of hepatopulmonary syndrome: Impact of liver transplantation. (15828054)
2005
20
Estrogen promotes intrapulmonary vasodilatation in hepatopulmonary syndrome. (16024287)
2005
21
Congenital absence of portal vein presenting as hepatopulmonary syndrome. (15670231)
2005
22
The hepatopulmonary syndrome: NO way out? (15176675)
2004
23
Case report of unchanged tacrolimus clearance in a hypoxemic pediatric liver transplant recipient with hepatopulmonary syndrome. (15502939)
2004
24
Severe polycythemia as the first clinical presentation of hepatopulmonary syndrome. (12811222)
2003
25
Liver transplantation for hepatopulmonary syndrome: a ten-year experience in Paris, France. (12792501)
2003
26
Hepatopulmonary syndrome in noncirrhotic portal hypertensive patients. (12757170)
2003
27
Case 63: hepatopulmonary syndrome. (14519870)
2003
28
Hepatopulmonary syndrome. (12421031)
2002
29
Biliary cyst fluid from common bile duct-ligated rats stimulates endothelial nitric oxide synthase in pulmonary artery endothelial cells: a potential role in hepatopulmonary syndrome. (11230754)
2001
30
Methylene blue improves the hepatopulmonary syndrome. (11529704)
2001
31
Prevalence of hepatopulmonary syndrome in cirrhosis and extrahepatic portal venous obstruction. (11774955)
2001
32
Hepatopulmonary Syndrome and Portopulmonary Hypertension. (11696280)
2001
33
Hepatopulmonary syndrome in noncirrhotic portal hypertension. (10836927)
2000
34
Hepatopulmonary Syndrome and Liver Transplantation. (10648589)
2000
35
Portal hypertension and hepatopulmonary syndrome in a middle-aged man with hepatitis B infection. (11076405)
2000
36
Hepatopulmonary syndrome: a prospective study of relationships between severity of liver disease, PaO(2) response to 100% oxygen, and brain uptake after (99m)Tc MAA lung scanning. (10988181)
2000
37
Methylene blue improves the hepatopulmonary syndrome. (11074903)
2000
38
Hepatopulmonary syndrome in Gaucher disease with right-to-left shunt: evaluation and measurement using Tc-99m MAA. (10069725)
1999
39
Late recurrence and rapid evolution of severe hepatopulmonary syndrome after liver transplantation. (10477847)
1999
40
Localizing intrapulmonary shunt in hepatopulmonary syndrome by transesophageal echocardiography. (10506859)
1999
41
Pulmonary hypertension following hepatopulmonary syndrome in a patient with cirrhosis. (10453952)
1999
42
Hepatopulmonary syndrome after allogeneic bone marrow transplantation. (10642817)
1999
43
Hepatopulmonary syndrome associated with sarcoidosis of the liver: case report. (9879271)
1998
44
Severe pulmonary hypertension and amelioration of hepatopulmonary syndrome after liver transplantation. (9516572)
1998
45
Diagnosis of hepatopulmonary syndrome with contrast transthoracic echocardiography and histological confirmation. (9766826)
1998
46
Hepatopulmonary syndrome and radionuclide lung perfusion imaging. (9712400)
1998
47
Hepatopulmonary syndrome: the paradigm of liver-induced hypoxaemia. (9395754)
1997
48
The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome. (9247483)
1997
49
Elevated exhaled nitric oxide in patients with hepatopulmonary syndrome. (8620957)
1995
50
The hepatopulmonary syndrome masquerading as pulmonary Langerhans-cell histiocytosis. Hepatopulmonary Syndrome Study Group. (8198345)
1994

Variations for Hepatopulmonary Syndrome

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Expression for genes affiliated with Hepatopulmonary Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatopulmonary Syndrome

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Pathways for genes affiliated with Hepatopulmonary Syndrome

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Compounds for genes affiliated with Hepatopulmonary Syndrome

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Sources:
29IUPHAR, 45Novoseek, 61Tocris Bioscience, 11DrugBank, 24HMDB, 51PharmGKB
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Compounds related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1auranofin29 45 61 1113.2ALB, HMOX1
2Bilirubin2410.2HMOX1, ALB
3isoflurane51 45 1112.2HMOX1, ALB
4propofol45 51 1112.1HMOX1, ALB
5clomipramine45 51 1112.1HTR2B, ALB
6fluoxetine45 51 29 1113.0HTR2B, ALB
7polyethylene glycol459.9HMOX1, ALB
8olanzapine45 51 29 24 1113.9HTR2B, ALB
9vitamin b6459.8BHMT, ALB
10salicylic acid45 2910.8ALB, HMOX1
11vitamin b12459.7BHMT, ALB
12histamine45 29 2411.6HMOX1, ALB, PI3
13fatty acid459.1ALB, CAV3, PI3
14nitric oxide45 24 1111.0HTR2B, HMOX1, CAV3, PI3
15glucose459.0NR0B2, ALB, CAV3, GDF2
16cysteine459.0HMOX1, ALB, PI3, BHMT
17oxygen45 249.4HMOX1, HTR2B, KCNA5, PI3, C4A
18lipid458.4CAV3, ALB, NR0B2, PI3
19calcium45 51 24 1110.9NR0B2, PI3, KCNA5, CELA1, HTR2B, CAV3

GO Terms for genes affiliated with Hepatopulmonary Syndrome

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16Gene Ontology
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Cellular components related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Z discGO:0300189.5CAV3, KCNA5
2caveolaGO:0059019.2HMOX1, CAV3, KCNA5
3protein complexGO:0432348.8BHMT, NR0B2, ALB

Biological processes related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of angiogenesisGO:0457669.8HMOX1, GDF2
2negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.8NR0B2, HMOX1
3cellular iron ion homeostasisGO:0068799.7HMOX1, GDF2
4regulation of membrane potentialGO:0423919.5KCNA5, CAV3
5positive regulation of endothelial cell proliferationGO:0019389.5HTR2B, GDF2

Molecular functions related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.8ALB, HTR2B
2potassium channel inhibitor activityGO:0198709.5CAV3, KCNA5
3endopeptidase inhibitor activityGO:0048668.8C4A, PI3
4protein complex bindingGO:0324038.8BHMT, NR0B2, CAV3

Products for genes affiliated with Hepatopulmonary Syndrome

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Sources for Hepatopulmonary Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet