MCID: HPT009
MIFTS: 47

Hepatopulmonary Syndrome malady

Liver category

Summaries for Hepatopulmonary Syndrome

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 In medicine, hepatopulmonary syndrome is a syndrome of shortness of breath and hypoxemia (low oxygen... more...

MalaCards: Hepatopulmonary Syndrome is related to vascular disease and biliary atresia. An important gene associated with Hepatopulmonary Syndrome is HMOX1 (heme oxygenase (decycling) 1), and among its related pathways is Bile secretion. The compounds oxygen and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and smooth muscle, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Aliases & Classifications for Hepatopulmonary Syndrome

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver


Aliases & Descriptions:

hepatopulmonary syndrome 8 10 45 61


External Ids:

Disease Ontology8 DOID:900
SNOMED-CT57 371067004
MeSH35 D020065

Related Diseases for Hepatopulmonary Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hepatopulmonary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease30.2ACVRL1, BHMT, NOX1, HMOX1
2biliary atresia30.2SLC10A2, SLC10A1
3arteriovenous malformation30.0ACVRL1
4n syndrome10.8
5portal hypertension10.5
6hepatitis c10.3
7image syndrome10.3
8hepatitis c virus10.3
9gaucher's disease10.2
10adult syndrome10.2
11hepatitis a10.2
12char syndrome10.2
13short syndrome10.2
14hypoxia10.2
15primary pulmonary hypertension10.0
16cardiac tamponade10.0
17cystic fibrosis10.0
18dyskeratosis congenita10.0
19hepatitis e10.0
20primary biliary cirrhosis10.0
21good syndrome10.0
22granulomatous hepatitis10.0
23fatty liver disease10.0
24hepatorenal syndrome10.0
25brain disease10.0
26congenital hepatic fibrosis10.0
27congenital extrahepatic portosystemic shunt10.0
28mass syndrome10.0
29pulmonary function10.0
30hemorrhage, intracerebral10.0
31somatostatin analog10.0
32cirrhotic cardiomyopathy10.0
33galactosemia10.0ALB
34pancreatitis10.0ALB, CELA1
35hypertension10.0KCNA5, NOX1, ALB
36atherosclerosis10.0NOX1, ACVRL1, SLC10A2, HMOX1, PI3, ALB
37hepatocellular carcinoma10.0BHMT, ALB
38adenoma10.0NOX1, DUOX2, CAV2, DUOX1
39congenital hypothyroidism10.0DUOX2, DUOX1
40adenocarcinoma10.0RARG, CAV2, HMOX1, NOX1
41chronic granulomatous disease10.0DUOX1, DUOX2
42obesity10.0HMOX1, NR0B2
43cholestasis10.0ALB, SLC10A2, NR0B2, SLC10A1
44sepsis10.0PI3, ALB, HMOX1, C4A
45hypercholesterolemia10.0SLC10A2
46diarrhea10.0ALB
47hepatitis b10.0ALB
48ulcerative colitis10.0ALB
49primary hyperoxaluria10.0NOX1, C4A, HMOX1, ALB
50uremia10.0ALB

Graphical network of the top 20 diseases related to Hepatopulmonary Syndrome:



Diseases related to hepatopulmonary syndrome

Clinical Features for Hepatopulmonary Syndrome

Drugs & Therapeutics for Hepatopulmonary Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hepatopulmonary Syndrome

Drug clinical trials:

Search ClinicalTrials for Hepatopulmonary Syndrome

Search NIH Clinical Center for Hepatopulmonary Syndrome

Search CenterWatch for Hepatopulmonary Syndrome

Genetic Tests for Hepatopulmonary Syndrome

Anatomical Context for Hepatopulmonary Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Hepatopulmonary Syndrome:

33
Bone marrow, Brain, Smooth muscle, Liver, Lung, Skin, Monocytes, B cells, Endothelial

Animal Models for Hepatopulmonary Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hepatopulmonary Syndrome

Sources:
51PubMed
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Articles related to Hepatopulmonary Syndrome:

(show top 50)    (show all 390)
idTitleAuthorsYear
1
Transition from hepatopulmonary syndrome to portopulmonary hypertension: a case series of 3 patients. (24324910)
2013
2
Hepatopulmonary syndrome: the anaesthetic considerations. (24161936)
2013
3
Effect of annexin A2 on hepatopulmonary syndrome rat serum-induced proliferation of pulmonary arterial smooth muscle cells. (23059374)
2013
4
Expression of the 78kD glucose-regulated protein is induced by endoplasmic reticulum stress in the development of hepatopulmonary syndrome. (24334118)
2013
5
Hepatopulmonary syndrome and portopulmonary hypertension. (23680738)
2013
6
Detection of hepatopulmonary syndrome in patients with liver cirrhosis using 3D contrast echocardiography. (22560819)
2012
7
The role of CXa88CL1/CXa88CR1 in pulmonary angiogenesis and intravascular monocyte accumulation in rat experimental hepatopulmonary syndrome. (22659346)
2012
8
Pentoxifylline in hepatopulmonary syndrome. (23002364)
2012
9
Effects of caffeic acid phenethyl ester (CAPE) on hepatopulmonary syndrome. (21046212)
2011
10
Living donor liver transplantation for end-stage liver disease with severe hepatopulmonary syndrome: report of a case. (21365433)
2011
11
Left ventricle enlargement and increased systolic velocity in the mitral valve are indirect markers of the hepatopulmonary syndrome. (21771264)
2011
12
Improvement in hepatopulmonary syndrome after methadone withdrawal: a case report with implications for disease mechanism. (20583080)
2010
13
Pushing the boundaries in hepatopulmonary syndrome. (19958322)
2010
14
Inferior vena cava stent resolves hepatopulmonary syndrome in an adult with a spontaneous inferior vena cava-portal vein shunt. (19938123)
2009
15
Sarcoidosis complicated by cirrhosis and hepatopulmonary syndrome. (18437252)
2008
16
Hepatopulmonary syndrome: use of extracorporeal life support for life-threatening hypoxia following liver transplantation. (18581508)
2008
17
Hepatopulmonary syndrome--a liver-induced lung vascular disorder. (18509123)
2008
18
N-acetylcysteine effects on genotoxic and oxidative stress parameters in cirrhotic rats with hepatopulmonary syndrome. (18341514)
2008
19
Childhood cirrhosis, hepatopulmonary syndrome and liver transplantation. (18435611)
2008
20
Therapy Insight: hepatopulmonary syndrome and orthotopic liver transplantation. (17978818)
2007
21
Resolution of hepatopulmonary syndrome after auxiliary partial orthotopic liver transplantation in Abernethy malformation. A case report. (18044784)
2007
22
Evaluation of the protective effects of quercetin in the hepatopulmonary syndrome. (17306429)
2007
23
Two successful pregnancies in a patient with advanced liver cirrhosis and hepatopulmonary syndrome. (21960863)
2007
24
Liver transplantation of a child with child a cirrhosis and severe hepatopulmonary syndrome. (16797324)
2006
25
Hepatopulmonary syndrome in patients with hypoxic hepatitis. (16831591)
2006
26
Cirrhotic rats with bacterial translocation have higher incidence and severity of hepatopulmonary syndrome. (16174071)
2005
27
Intrapulmonary shunting and hepatopulmonary syndrome. (15920866)
2005
28
Portopulmonary hypertension and hepatopulmonary syndrome. (15121411)
2004
29
Prevention of hepatopulmonary syndrome and hyperdynamic state by pentoxifylline in cirrhotic rats. (15176692)
2004
30
Hepatopulmonary syndrome and portopulmonary hypertension in the model for end-stage liver disease (MELD) era. (15382220)
2004
31
Hepatopulmonary syndrome in noncirrhotic portal hypertensive patients. (12757170)
2003
32
Hepatopulmonary syndrome. A review of the literature. (12855933)
2003
33
Retrospective analysis of the results of liver transplantation for adults with severe hepatopulmonary syndrome. (12360435)
2002
34
Hepatopulmonary syndrome in candidates for liver transplantation. (11434610)
2001
35
Use of transjugular intrahepatic portosystemic shunt as a bridge to liver transplantation in a patient with severe hepatopulmonary syndrome. (11172400)
2001
36
Hepatopulmonary syndrome. (19861775)
2001
37
Hepatopulmonary syndrome occurring after orthotopic liver transplantation. (11753911)
2001
38
Hepatopulmonary syndrome: prevalence and clinical profile. (11206870)
2001
39
Tc-99m MAA perfusion lung scanning in hepatopulmonary syndrome. (10439192)
1999
40
Post-surgical shunt hepatopulmonary syndrome in a case of non-cirrhotic portal hypertension: lack of efficacy of shunt reversal. (10654806)
1999
41
The hepatopulmonary syndrome. (10073180)
1999
42
Severe portopulmonary hypertension after liver transplantation in a patient with preexisting hepatopulmonary syndrome. (10604582)
1999
43
Hepatopulmonary syndrome associated with sarcoidosis of the liver: case report. (9879271)
1998
44
Hepatopulmonary syndrome with progressive hypoxemia as an indication for liver transplantation: case reports and literature review. (9005286)
1997
45
The hepatopulmonary syndrome. Effect of liver transplantation. (8665784)
1996
46
Hepatopulmonary syndrome. A pulmonary vascular complication of liver disease. (8665789)
1996
47
Hepatopulmonary syndrome in a child. (17589030)
1995
48
Methylene blue in the hepatopulmonary syndrome. (8090178)
1994
49
Hepatopulmonary syndrome. Clinical observations and lack of therapeutic response to somatostatin analogue. (8101797)
1993
50
Ancient remedies revisited: does Allium sativum (garlic) palliate the hepatopulmonary syndrome? (1479173)
1992

Genetic Variations for Hepatopulmonary Syndrome

Expression for genes affiliated with Hepatopulmonary Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatopulmonary Syndrome

Search GEO for disease gene expression data for Hepatopulmonary Syndrome.

Pathways for genes affiliated with Hepatopulmonary Syndrome

Sources:
30KEGG
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Pathways related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5SLC10A1, SLC10A2, NR0B2

Compounds for genes affiliated with Hepatopulmonary Syndrome

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1oxygen45 2411.8NOX1, KCNA5, HTR2B, C4A, PI3, DUOX1
2cholesterol45 29 11 2413.8CAV2, CAV3, NR0B2, SLC10A2, SLC10A1, ALB
3glycochenodeoxycholic acid45 1111.8SLC10A2, SLC10A1
4nadph45 2411.8NOX1, HMOX1, DUOX2, DUOX1, HTR2B
5chenodeoxycholic acid45 29 11 2413.8SLC10A1, SLC10A2, NR0B2
6calcium45 50 11 2413.8KCNA5, CAV3, HTR2B, PI3, NR0B2, DUOX1
7superoxide45 2411.7PI3, DUOX1, DUOX2, HMOX1, NOX1
8nitric oxide45 11 2412.7CAV2, CAV3, HTR2B, PI3, HMOX1, NOX1
9sodium45 2411.7CAV3, DUOX2, SLC10A2, SLC10A1, ALB
101,3,7,12-Tetrahydroxycholan-24-oic acid2410.7SLC10A2, SLC10A1
111,3,12-Trihydroxycholan-24-oic acid2410.7SLC10A2, SLC10A1
12(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid2410.7SLC10A2, SLC10A1
13h2o24510.6NOX1, HMOX1, DUOX2, DUOX1, KCNA5
14Pitavastatin1110.6SLC10A1, ALB
15serine4510.6ACVRL1, SLC10A2, RARG, BHMT, PI3, C4A
16Liotrix1110.5SLC10A1, ALB
17auranofin45 60 29 1113.5ALB, HMOX1
18cyclosporine50 1111.5SLC10A1, SLC10A2
19Liothyronine11 2411.4ALB, SLC10A1
20acitretin45 1111.2ALB, RARG

GO Terms for genes affiliated with Hepatopulmonary Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:04512110.5CAV3, CAV2, KCNA5
2caveolaGO:00590110.4HMOX1, CAV3, CAV2, KCNA5
3protein complexGO:04323410.2CAV2, NR0B2, BHMT, ALB

Biological processes related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1bile acid and bile salt transportGO:01572110.8SLC10A2, SLC10A1, ALB
2positive regulation of endothelial cell proliferationGO:00193810.8ACVRL1, GDF2, HTR2B, CAV2
3negative regulation of endothelial cell proliferationGO:00193710.7ACVRL1, GDF2, CAV2
4bile acid metabolic processGO:00820610.7ALB, SLC10A1, SLC10A2
5cuticle developmentGO:04233510.7DUOX1, DUOX2
6caveola assemblyGO:07083610.7CAV3, CAV2
7negative regulation of DNA biosynthetic processGO:200027910.7ACVRL1, GDF2
8regulation of blood pressureGO:00821710.7HMOX1, NOX1, ACVRL1
9positive regulation of endothelial cell differentiationGO:04560310.6ACVRL1, GDF2
10hormone biosynthetic processGO:04244610.6DUOX2, DUOX1
11negative regulation of blood vessel endothelial cell migrationGO:04353710.6GDF2, ACVRL1
12superoxide anion generationGO:04255410.5DUOX1, NOX1
13negative regulation of endothelial cell migrationGO:01059610.5GDF2, ACVRL1
14hydrogen peroxide catabolic processGO:04274410.5DUOX2, DUOX1
15thyroid hormone generationGO:00659010.4DUOX1, DUOX2
16oxidation-reduction processGO:05511410.1NOX1, DUOX2, DUOX1

Molecular functions related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1potassium channel inhibitor activityGO:01987010.6CAV3, KCNA5
2bile acid:sodium symporter activityGO:00850810.6SLC10A1, SLC10A2
3NAD(P)H oxidase activityGO:01617410.5DUOX2, DUOX1
4retinoid X receptor bindingGO:04696510.5RARG, NR0B2
5peroxidase activityGO:00460110.5DUOX2, DUOX1
6protein complex bindingGO:03240310.4CAV3, NR0B2, BHMT
7heme bindingGO:02003710.2HMOX1, DUOX2, DUOX1

Products for genes affiliated with Hepatopulmonary Syndrome

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Sources for Hepatopulmonary Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet