MCID: HPT009
MIFTS: 39

Hepatopulmonary Syndrome malady

Gastrointestinal diseases, Liver diseases categories

Aliases & Classifications for Hepatopulmonary Syndrome

About this section
Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 36MeSH, 59SNOMED-CT
See all sources

Aliases & Descriptions for Hepatopulmonary Syndrome:

Name: Hepatopulmonary Syndrome 10 47 12 65 36


Classifications:



External Ids:

Disease Ontology10 DOID:900
SNOMED-CT59 371067004
MeSH36 D020065

Summaries for Hepatopulmonary Syndrome

About this section
Wikipedia:68 In medicine, hepatopulmonary syndrome is a syndrome of shortness of breath and hypoxemia (low oxygen... more...

MalaCards based summary: Hepatopulmonary Syndrome is related to liver disease and portal hypertension. An important gene associated with Hepatopulmonary Syndrome is ALB (Albumin), and among its related pathways are Plasma membrane estrogen receptor signaling and Platelet activation. Affiliated tissues include liver, lung and endothelial, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Related Diseases for Hepatopulmonary Syndrome

About this section

Diseases related to Hepatopulmonary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1liver disease10.7
2portal hypertension10.6
3hepatitis10.6
4liver cirrhosis10.6
5pulmonary hypertension10.5
6endotheliitis10.5
7galactosemia10.4
8adult syndrome10.4
9budd-chiari syndrome10.3
10hepatitis b10.3
11hepatitis a10.3
12congenital hepatic fibrosis10.3
13procarcinoma10.3EDN1, NOS3
14unilateral hyperactive labyrinth10.3ALB, EDNRB
15acute eustachian salpingitis10.3EDN1, NOS3
16congenital chloride diarrhea10.2EDN1, VWF
17elastoderma10.2EDN1, VWF
18aortic dissection lentiginosis10.2EDN1, NOS3
19hepatitis c virus10.2
20biliary atresia10.2
21langerhans-cell histiocytosis10.2
22hepatitis c10.2
23blood platelet disease10.2
24histiocytosis10.2
25hypopituitarism10.2
26congenital extrahepatic portosystemic shunt10.2
27cardiomyopathy10.2
28hypoxia10.2
29cirrhotic cardiomyopathy10.2
30calpainopathy10.2ALB, TNF
31rheumatic fever10.2EDN1, NOS3
32hepatoblastoma10.2ALB, EDN1, NOS3
33parotitis10.2EDN1, VWF
34chronic salpingo-oophoritis10.2EDN1, HMOX1, NOS3
35hemiplegia alterans10.2NOS3, VEGFA
36hypertensive nephropathy10.1ALB, VEGFA
37malignant cardiac germ cell tumor10.1ALB, VEGFA
38chronic venous leg ulcers10.1NOS3, VEGFA
39chromoblastomycosis10.1HMOX1, TNF
40echinostomiasis10.1EDN1, TNF
41fallopian tube cystadenofibroma10.1TNF, VWF
42chronic purulent otitis media10.1EDN1, TNF
43ischemic optic neuropathy10.1NOS3, TNF
44gastric antral vascular ectasia10.1VEGFA, VWF
45pulmonary valve agenesis - fallot's tetralogy - absence of ductus arteriosus10.1TNF, VWF
46complement deficiency10.1ALB, TNF
47focal chorioretinitis10.1ALB, EDN1, TNF
48kosztolanyi syndrome10.1ALB, EDNRA
49nodular malignant melanoma10.1EDN1, NOS3, TNF
50fallopian tube leiomyoma10.1EDN1, NOS3, TNF

Graphical network of the top 20 diseases related to Hepatopulmonary Syndrome:



Diseases related to hepatopulmonary syndrome

Symptoms for Hepatopulmonary Syndrome

About this section

Drugs & Therapeutics for Hepatopulmonary Syndrome

About this section

Drugs for Hepatopulmonary Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
NorfloxacinapprovedPhase 21570458-96-74539
Synonyms:
1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[1-piperazinyl]-3-quinoline- carboxylic acid
1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
68077-27-0
70458-96-7
AC-6855
AC1L1IE1
AKOS000417391
AM 0715
AM 715
AM-0715
AM-715
AM0715
ARONIS24170
BB_SC-0063
BCBcMAP01_000218
BIDD:GT0725
BPBio1_000289
BRD-K11196887-001-05-5
BRN 0567897
BSPBio_000261
BSPBio_002107
Baccidal
Barazan
C06687
C16H18FN3O3
CAS-70458-96-7
CCRIS 6302
CHEBI:100246
CHEMBL9
CID4539
Chibroxin
Chibroxin, MK-366, Baccidal, Sebercim, Zoroxin, Norfloxacin
D00210
D009643
DB01059
DivK1c_000084
EINECS 274-614-4
Fulgram
HMS1568N03
HMS1920B16
HMS2090F03
HMS2091J16
HMS500E06
I14-0947
IDI1_000084
KBio1_000084
KBio2_001497
KBio2_004065
 
KBio2_006633
KBio3_001607
KBioGR_000866
KBioSS_001497
LS-141592
Lexinor
MK 0366
MK 366
MK-0366
MK-366
MK0366
MK366
MLS000069650
Merck Brand of Norfloxacin
MolPort-001-738-625
NCGC00016916-01
NCGC00016916-02
NCGC00021725-03
NCGC00021725-04
NFLX
NINDS_000084
Norflo
Norfloxacin (JP15/USP/INN)
Norfloxacin Merck Brand
Norfloxacin [USAN:BAN:INN:JAN]
Norfloxacine
Norfloxacine [INN-French]
Norfloxacino
Norfloxacino [INN-Spanish]
Norfloxacinum
Norfloxacinum [INN-Latin]
Noroxin
Noroxin (TN)
Oprea1_375152
Prestwick0_000221
Prestwick1_000221
Prestwick2_000221
Prestwick3_000221
Prestwick_633
S1509_Selleck
SMP1_000216
SMR000058200
SPBio_001173
SPBio_002182
SPECTRUM1500440
STK177250
Sebercim
Spectrum2_001017
Spectrum3_000524
Spectrum4_000453
Spectrum5_001154
Spectrum_001017
UNII-N0F8P22L1P
nchembio820-comp2
norfloxacin
2
Bosentanapproved, investigationalPhase 299147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
Bosentanum
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
 
DB00559
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentanum
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
3
Sorafenibapproved, investigationalPhase 2653284461-73-0216239, 406563
Synonyms:
284461-73-0
4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate
4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
AB1004622
AC-1674
AC1L50CF
BAX
BAY 43-9006
BAY 43-9006 (free base)
BAY 43-9006 tosylate salt
BAY 439006
BAY 54-9085 (tosylate salt)
BAY-43-0006
BAY-43-9006
BAY-54-9085
BAY43-9006
BRD-K23984367-001-01-8
Bio-0100
CHEBI:47228
CHEBI:50924
CHEMBL1336
CID216239
 
D08524
DB00398
DB07438
EN002709
I06-0856
K00597a
Kinome_766
LS-186067
LS-187021
LS-187788
MolPort-003-850-270
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea
NCGC00167488-01
NSC-724772
NSC747971
Nexavar
STK627350
Sorafenib
Sorafenib (INN)
Sorafenib Tosylate
Sorafenib [INN]
Sorafenib tosylate
Sorafenibum
UNII-9ZOQ3TZI87
ZINC01493878
nchembio.117-comp17
sorafenib
sorafenibum
4
IodinePhase 24597553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
5cadexomer iodinePhase 2425
6
Pentoxifyllineapproved, investigationalPhase 1886493-05-64740
Synonyms:
1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion
1-(5-Oxohexyl)-3,7-dimethylxanthine
1-(5-Oxohexyl)theobromine
2a3c
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl) xantine
3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)xanthine
3,7-Dimethyl-1-(5-oxohexyl)xantine
3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
5-26-14-00081 (Beilstein Handbook Reference)
6493-05-6
AB00052363
AC1L1IUN
AKOS000541484
Agapurin
Agapurin Retard
Azupentat
BAS 00897429
BB_SC-2111
BIDD:GT0174
BL 191
BL-191
BL191
BPBio1_000167
BRD-K57569181-001-05-1
BRN 0558929
BSPBio_000151
BSPBio_003439
C07424
C13H18N4O3
CAS-1677687
CCRIS 6832
CHEMBL628
CID4740
CPD000035998
D00501
D010431
DB00806
Dimethyloxohexylxanthine
DivK1c_000729
Durapental
EHT 0201
EHT-0201
EHT-201
EHT0201
EINECS 229-374-5
EU-0100936
HMS1568H13
HMS1922E16
HMS2051N06
HMS2090H13
HMS2093G21
HMS502E11
Hemovas
I06-1592
IDI1_000729
IN1161
Ikomio
KBio1_000729
KBio2_001924
KBio2_004492
KBio2_007060
KBio3_002942
KBioGR_000893
KBioSS_001924
LS-149385
 
Lopac-P-1784
Lopac0_000936
MLS000079026
MLS000758298
MLS001201764
MolPort-001-823-263
NCGC00015801-01
NCGC00015801-02
NCGC00015801-04
NCGC00015801-10
NCGC00067069-02
NCGC00067069-03
NCGC00067069-04
NCGC00067069-05
NCGC00178062-01
NCGC00178062-02
NINDS_000729
NSC 637086
NSC637086
Oxpentifylline
P 1784
PDSP1_001015
PDSP2_000999
PENTOXYPHYLINE
PNX
Pentoxifilina
Pentoxifilina [INN-Spanish]
Pentoxifyllin
Pentoxifylline
Pentoxifylline (JAN/USP/INN)
Pentoxifylline [USAN:INN:JAN]
Pentoxifyllinum
Pentoxifyllinum [INN-Latin]
Pentoxil
Pentoxil (TN)
Pentoxiphyllin
Pentoxiphylline
Pentoxiphyllium
Pentoxyfylline
Pentoxyphyllin
Pentoxyphylline
Prestwick0_000196
Prestwick1_000196
Prestwick2_000196
Prestwick3_000196
Prestwick_608
Px
Ralofect
Rentylin
SAM001247011
SMR000035998
SPBio_001221
SPBio_002072
SPECTRUM1503611
SR-01000075641-4
STK177321
Spectrum2_001181
Spectrum3_001820
Spectrum4_000227
Spectrum5_001161
Spectrum_001444
Torental
Trental
Trental (TN)
UNII-SD6QCT3TSU
Vasofirin
Vazofirin
ZINC01530776
cis-9-Octadecenoyl coenzyme A
pentoxifylline
7
Rifaximinapproved, investigational9080621-81-46436173
Synonyms:
(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate
4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV
4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin
80621-81-4
88747-56-2
AC-19112
BRN 3584528
Bio-0556
C43H51N3O11
CHEMBL1617
D02554
DB01220
Fatroximin
Flonorm
L 105
L 105 (Ansamacrolide antibiotic)
L 105SV
LS-178059
LS-64147
Lormyx
Lumenax
MLS000759430
Normix
RedActiv
Rifacol
 
Rifamixin
Rifamycin L 105
Rifamycin L 105SV
Rifaxidin
Rifaximin
Rifaximin (USAN/INN)
Rifaximin [USAN:INN]
Rifaximina
Rifaximina [Spanish]
Rifaximine
Rifaximine [French]
Rifaximinum
Rifaximinum [Latin]
Rifaximinun
Rifaxin
Ritacol
S1790_Selleck
SMR000466324
Spiraxin
UNII-L36O5T016N
Xifaxan
Xifaxan, Rifacol, Fatroximin, Rifaximin
Xifaxsan
Xifaxsan (TN)
Zaxine
alpha-0817185

Interventional clinical trials:

idNameStatusNCT IDPhase
1Echocardiographic Assessment of Intrapulmonary Vasodilatation: Agitated Saline Versus PolygelineRecruitingNCT00343122Phase 4
2A Pilot Study of Norfloxacin for Hepatopulmonary SyndromeCompletedNCT00362752Phase 2
3Sorafenib for Hepatopulmonary SyndromeRecruitingNCT02021929Phase 2
4Bosentan for Treatment of Hepatopulmonary Syndrome in Patients With Liver CirrhosisRecruitingNCT01518595Phase 2
5Pilot Study of Pentoxifylline for Hepatopulmonary SyndromeTerminatedNCT00593658Phase 1
6Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary SyndromeRecruitingNCT02148536
7Efficacy of Pentoxifylline and Rifaximin Combination in Pentoxifylline Refractory Clinical and Subclinical Hepatopulmonary SyndromeRecruitingNCT01676597

Search NIH Clinical Center for Hepatopulmonary Syndrome


Cochrane evidence based reviews: Hepatopulmonary Syndrome

Genetic Tests for Hepatopulmonary Syndrome

About this section

Anatomical Context for Hepatopulmonary Syndrome

About this section

MalaCards organs/tissues related to Hepatopulmonary Syndrome:

33
Liver, Lung, Endothelial, Bone, Smooth muscle, Brain, Monocytes

Animal Models for Hepatopulmonary Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Hepatopulmonary Syndrome:

38 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3AKT1, ALB, EDNRB, TNF, VEGFA
2MP:00053708.0AKT1, ALB, HMOX1, NOS3, NR0B2, TNF
3MP:00053677.8ALB, EDN1, EDNRA, EDNRB, HMOX1, NOS3
4MP:00053807.7AKT1, EDN1, EDNRA, EDNRB, TNF, VEGFA
5MP:00028737.7AKT1, ALB, EDN1, EDNRA, NOS3, NR0B2
6MP:00053907.5AKT1, EDN1, EDNRA, EDNRB, NOS3, TNF
7MP:00053887.3AKT1, EDNRA, EDNRB, HMOX1, NOS3, TNF
8MP:00053847.2AKT1, ALB, CAV3, EDNRB, HMOX1, NOS3
9MP:00053816.8ALB, EDN1, EDNRA, EDNRB, NOS3, NR0B2
10MP:00036316.8AKT1, EDN1, EDNRA, EDNRB, NOS3, TNF
11MP:00053796.5AKT1, ALB, EDN1, EDNRA, HMOX1, NOS3
12MP:00107686.4AKT1, ALB, EDN1, EDNRA, EDNRB, HMOX1
13MP:00053696.3AKT1, ALB, CAV3, EDN1, EDNRA, EDNRB
14MP:00053856.2AKT1, CAV3, EDN1, EDNRA, EDNRB, HMOX1
15MP:00053876.0AKT1, CAV3, EDNRA, EDNRB, HMOX1, NOS3
16MP:00053765.1AKT1, ALB, CAV3, EDN1, EDNRA, EDNRB

Publications for Hepatopulmonary Syndrome

About this section

Articles related to Hepatopulmonary Syndrome:

(show top 50)    (show all 432)
idTitleAuthorsYear
1
Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment. (25627425)
2015
2
Prevalence and impact on survival of hepatopulmonary syndrome and cirrhotic cardiomyopathy in a cohort of cirrhotic patients. (25974637)
2015
3
Variability of Oxygenation in Possible Hepatopulmonary Syndrome: Effects of Requiring Two Abnormal Arterial Blood Gas Results for Diagnosis. (25586084)
2015
4
Aggravation of hepatopulmonary syndrome after sildenafil treatment in a patient with coexisting portopulmonary hypertension. (25653708)
2015
5
Congenital extrahepatic portosystemic shunt: an underdiagnosed but treatable cause of hepatopulmonary syndrome. (26311567)
2015
6
MiR-206 controls the phenotypic modulation of pulmonary arterial smooth muscle cells induced by serum from rats with hepatopulmonary syndrome by regulating the target gene, annexin A2. (25427750)
2014
7
Successful resolution of very severe hepatopulmonary syndrome following adult-to-adult living donor liver transplantation: Report of two cases. (25355534)
2014
8
Report of seven children with hepatopulmonary syndrome. (25599789)
2014
9
Are the spider angiomas skin markers of hepatopulmonary syndrome? (24322187)
2013
10
Pharmacological treatment for hepatopulmonary syndrome. (24102057)
2013
11
Detection of hepatopulmonary syndrome in patients with liver cirrhosis using 3D contrast echocardiography. (22560819)
2012
12
Effects of caffeic acid phenethyl ester (CAPE) on hepatopulmonary syndrome. (21046212)
2011
13
Physiopathological, clinical and therapeutic aspects of hepatopulmonary syndrome. (20589345)
2010
14
Attenuation of experimental hepatopulmonary syndrome in endothelin B receptor-deficient rats. (19196949)
2009
15
Sarcoidosis complicated by cirrhosis and hepatopulmonary syndrome. (18437252)
2008
16
Current concepts in the management of hepatopulmonary syndrome. (19183751)
2008
17
Pentoxifylline therapy for hepatopulmonary syndrome: a pilot study. (18779471)
2008
18
Value of contrast echocardiography for the diagnosis of hepatopulmonary syndrome. (17011830)
2007
19
Successful liver retransplantation for recurrent hepatopulmonary syndrome. (17976130)
2007
20
Hepatopulmonary syndrome. (17722431)
2007
21
Congenital portocaval fistula associated with hepatopulmonary syndrome: ligation vs liver transplantation. (16481229)
2006
22
Liver transplantation of a child with child a cirrhosis and severe hepatopulmonary syndrome. (16797324)
2006
23
Effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome. (16688838)
2006
24
Hepatopulmonary syndrome can show spontaneous resolution: possible mechanism of portopulmonary hypertension overlap? (16423214)
2006
25
Natural history of hepatopulmonary syndrome: Impact of liver transplantation. (15828054)
2005
26
Estrogen promotes intrapulmonary vasodilatation in hepatopulmonary syndrome. (16024287)
2005
27
Congenital absence of portal vein presenting as hepatopulmonary syndrome. (15670231)
2005
28
Case report of unchanged tacrolimus clearance in a hypoxemic pediatric liver transplant recipient with hepatopulmonary syndrome. (15502939)
2004
29
Severe polycythemia as the first clinical presentation of hepatopulmonary syndrome. (12811222)
2003
30
Liver transplantation for hepatopulmonary syndrome: a ten-year experience in Paris, France. (12792501)
2003
31
Hepatopulmonary syndrome in noncirrhotic portal hypertensive patients. (12757170)
2003
32
Case 63: hepatopulmonary syndrome. (14519870)
2003
33
Biliary cyst fluid from common bile duct-ligated rats stimulates endothelial nitric oxide synthase in pulmonary artery endothelial cells: a potential role in hepatopulmonary syndrome. (11230754)
2001
34
Methylene blue improves the hepatopulmonary syndrome. (11529704)
2001
35
Prevalence of hepatopulmonary syndrome in cirrhosis and extrahepatic portal venous obstruction. (11774955)
2001
36
Hepatopulmonary Syndrome and Portopulmonary Hypertension. (11696280)
2001
37
Hepatopulmonary syndrome in noncirrhotic portal hypertension. (10836927)
2000
38
Hepatopulmonary Syndrome and Liver Transplantation. (10648589)
2000
39
Portal hypertension and hepatopulmonary syndrome in a middle-aged man with hepatitis B infection. (11076405)
2000
40
Hepatopulmonary syndrome: a prospective study of relationships between severity of liver disease, PaO(2) response to 100% oxygen, and brain uptake after (99m)Tc MAA lung scanning. (10988181)
2000
41
Hepatopulmonary syndrome in Gaucher disease with right-to-left shunt: evaluation and measurement using Tc-99m MAA. (10069725)
1999
42
Late recurrence and rapid evolution of severe hepatopulmonary syndrome after liver transplantation. (10477847)
1999
43
Localizing intrapulmonary shunt in hepatopulmonary syndrome by transesophageal echocardiography. (10506859)
1999
44
Pulmonary hypertension following hepatopulmonary syndrome in a patient with cirrhosis. (10453952)
1999
45
Hepatopulmonary syndrome associated with sarcoidosis of the liver: case report. (9879271)
1998
46
Severe pulmonary hypertension and amelioration of hepatopulmonary syndrome after liver transplantation. (9516572)
1998
47
Diagnosis of hepatopulmonary syndrome with contrast transthoracic echocardiography and histological confirmation. (9766826)
1998
48
Hepatopulmonary syndrome: the paradigm of liver-induced hypoxaemia. (9395754)
1997
49
Elevated exhaled nitric oxide in patients with hepatopulmonary syndrome. (8620957)
1995
50
The hepatopulmonary syndrome masquerading as pulmonary Langerhans-cell histiocytosis. Hepatopulmonary Syndrome Study Group. (8198345)
1994

Variations for Hepatopulmonary Syndrome

About this section

Expression for genes affiliated with Hepatopulmonary Syndrome

About this section
Search GEO for disease gene expression data for Hepatopulmonary Syndrome.

Pathways for genes affiliated with Hepatopulmonary Syndrome

About this section

Pathways related to Hepatopulmonary Syndrome according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8AKT1, NOS3
29.4AKT1, NOS3, VWF
3
Show member pathways
9.3EDN1, EDNRA
49.2AKT1, NOS3, TNF
59.2EDN1, NOS3, VEGFA
69.2AKT1, EDN1, TNF
79.2AKT1, EDN1, TNF
8
Show member pathways
9.1AKT1, NOS3, VEGFA
9
Show member pathways
9.1AKT1, NOS3, VEGFA
10
Angiogenesis (WikiPathways)
Show member pathways
9.1AKT1, NOS3, VEGFA
119.0EDN1, EDNRA, EDNRB
128.9AKT1, TNF, VEGFA
138.8AKT1, EDN1, HMOX1, VEGFA
148.8AKT1, NOS3, VEGFA, VWF
158.7EDN1, EDNRA, EDNRB, NOS3
16
Show member pathways
8.6AKT1, NOS3, TNF, VEGFA
17
Show member pathways
8.6AKT1, EDNRA, EDNRB, NOS3
188.5AKT1, EDN1, EDNRA, EDNRB
198.5AKT1, EDN1, HMOX1, NOS3, VEGFA
20
Show member pathways
8.5AKT1, ALB, NOS3, VEGFA, VWF
218.4AKT1, CAV3, TNF, VEGFA
228.2AKT1, EDNRA, EDNRB, VEGFA
23
Show member pathways
8.0AKT1, EDN1, EDNRA, NOS3, VEGFA
24
Show member pathways
7.1AKT1, EDN1, EDNRA, EDNRB, NOS3, TNF

GO Terms for genes affiliated with Hepatopulmonary Syndrome

About this section

Cellular components related to Hepatopulmonary Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Weibel-Palade bodyGO:003309310.4EDN1, VWF
2caveolaGO:00059019.7CAV3, HMOX1, NOS3
3platelet alpha granule lumenGO:00310939.6ALB, VEGFA, VWF
4protein complexGO:00432348.8AKT1, ALB, CAV3, NR0B2

Biological processes related to Hepatopulmonary Syndrome according to GeneCards Suite gene sharing:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle hyperplasiaGO:001480610.6HMOX1, NOS3
2regulation of systemic arterial blood pressure by endothelinGO:000310010.5EDN1, NOS3
3negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.5HMOX1, NOS3
4vein smooth muscle contractionGO:001482610.5EDN1, EDNRB
5negative regulation of cellular protein metabolic processGO:003226910.5EDN1, EDNRB
6positive regulation of urine volumeGO:003581010.5EDN1, EDNRB
7epithelial fluid transportGO:004204510.5EDN1, EDNRB
8response to fluid shear stressGO:003440510.4AKT1, NOS3
9positive regulation of vasodilationGO:004590910.4HMOX1, NOS3
10negative regulation of calcium ion transportGO:005192610.3CAV3, NOS3
11positive regulation of chemokine biosynthetic processGO:004508010.3HMOX1, TNF
12regulation of pHGO:000688510.3EDN1, EDNRB
13negative regulation of cell sizeGO:004579210.2AKT1, CAV3
14nitric oxide biosynthetic processGO:000680910.2AKT1, NOS3
15nitric oxide metabolic processGO:004620910.2AKT1, NOS3
16regulation of nitric-oxide synthase activityGO:005099910.1AKT1, NOS3
17positive regulation of renal sodium excretionGO:003581510.1EDN1, EDNRB
18cellular response to vascular endothelial growth factor stimulusGO:003592410.1AKT1, VEGFA
19positive regulation of blood vessel endothelial cell migrationGO:004353610.1AKT1, VEGFA
20endothelin receptor signaling pathwayGO:008610010.1EDNRA, EDNRB
21endothelial cell migrationGO:004354210.0NOS3, VEGFA
22neural crest cell developmentGO:001403210.0EDN1, EDNRA
23artery smooth muscle contractionGO:001482410.0EDN1, EDNRA
24positive regulation of protein complex assemblyGO:003133410.0TNF, VEGFA
25enteric nervous system developmentGO:00484849.9EDNRA, EDNRB
26negative regulation of cAMP biosynthetic processGO:00308189.8EDN1, EDNRA
27lipopolysaccharide-mediated signaling pathwayGO:00316639.8AKT1, NOS3, TNF
28positive regulation of smooth muscle cell proliferationGO:00486619.8EDN1, HMOX1, TNF
29platelet degranulationGO:00025769.8ALB, VEGFA, VWF
30positive regulation of angiogenesisGO:00457669.7HMOX1, NOS3, VEGFA
31positive regulation of nitric oxide biosynthetic processGO:00454299.6AKT1, EDN1, TNF
32vasoconstrictionGO:00423109.6EDN1, EDNRA, EDNRB
33glucose transportGO:00157589.5AKT1, EDN1, EDNRA
34negative regulation of gene expressionGO:00106299.5AKT1, NR0B2, TNF
35positive regulation of MAP kinase activityGO:00434069.4EDN1, TNF, VEGFA
36positive regulation of peptidyl-serine phosphorylationGO:00331389.4AKT1, TNF, VEGFA
37cellular response to hypoxiaGO:00714569.2AKT1, EDN1, HMOX1, VEGFA
38positive regulation of protein phosphorylationGO:00019349.0AKT1, EDNRB, TNF, VEGFA
39patterning of blood vesselsGO:00015699.0EDN1, EDNRA, VEGFA
40positive regulation of cell proliferationGO:00082849.0CAV3, EDN1, EDNRB, VEGFA
41positive regulation of cytosolic calcium ion concentrationGO:00072048.9CAV3, EDN1, EDNRA, EDNRB
42in utero embryonic developmentGO:00017018.9EDN1, EDNRA, NOS3, VEGFA
43regulation of blood pressureGO:00082178.8EDN1, EDNRA, EDNRB, HMOX1, NOS3
44response to hypoxiaGO:00016668.7EDN1, EDNRA, HMOX1, VEGFA
45platelet activationGO:00301688.5AKT1, ALB, VEGFA, VWF
46blood coagulationGO:00075968.4AKT1, ALB, NOS3, VEGFA, VWF
47negative regulation of transcription from RNA polymerase II promoterGO:00001228.2EDN1, EDNRB, NR0B2, TNF, VEGFA

Molecular functions related to Hepatopulmonary Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endothelin receptor activityGO:00049629.9EDNRA, EDNRB
2cytokine activityGO:00051259.0EDN1, TNF, VEGFA

Sources for Hepatopulmonary Syndrome

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet