MCID: HPT009
MIFTS: 46

Hepatopulmonary Syndrome malady

Gastrointestinal diseases, Liver diseases categories
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Summaries for Hepatopulmonary Syndrome

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Wikipedia:65 In medicine, hepatopulmonary syndrome is a syndrome of shortness of breath and hypoxemia (low oxygen... more...

MalaCards based summary: Hepatopulmonary Syndrome is related to cholestasis and cystic fibrosis. An important gene associated with Hepatopulmonary Syndrome is HMOX1 (heme oxygenase (decycling) 1). The compounds auranofin and Bilirubin have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and endothelial, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Hepatopulmonary Syndrome

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Hepatopulmonary Syndrome, Aliases & Descriptions:

Name: Hepatopulmonary Syndrome 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


External Ids:

Disease Ontology8 DOID:900
SNOMED-CT57 371067004
MeSH34 D020065

Related Diseases for Hepatopulmonary Syndrome

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Diseases related to Hepatopulmonary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1cholestasis30.3ALB, NR0B2
2cystic fibrosis30.0PI3, CELA1, ALB, HMOX1
3hypertension10.9
4liver disease10.7
5portal hypertension10.6
6hepatitis10.6
7liver cirrhosis10.5
8pulmonary hypertension10.4
9endotheliitis10.4
10sarcoidosis10.4
11bilirubin metabolic disorder10.3HMOX1, ALB
12cork-handlers' disease10.3ALB, HMOX1
13diabetes mellitus10.3HMOX1, ALB
14hepatitis b10.2
15langerhans-cell histiocytosis10.2
16hepatitis c10.2
17biliary atresia10.2
18hepatitis a10.2
19histiocytosis10.2
20hypopituitarism10.2
21hypoxia10.2
22hepatitis c virus10.2
23long qt syndrome10.2CAV3, KCNA5
24hyperhomocysteinemia10.2BHMT, ALB
25pancreatitis10.1ALB, CELA1
26chronic kidney failure10.1ALB, BHMT, HMOX1
27primary biliary cirrhosis10.1
28dyskeratosis congenita10.1
29granulomatous hepatitis10.1
30cardiac tamponade10.1
31fatty liver disease10.1
32hepatorenal syndrome10.1
33visceral leishmaniasis10.1
34arteriovenous malformation10.1
35ischemia10.1
36leishmaniasis10.1
37polycythemia10.1
38respiratory failure10.1
39congenital hepatic fibrosis10.1
40congenital extrahepatic portosystemic shunt10.1
41nodular regenerative hyperplasia10.1
42pulmonary function10.1
43cirrhotic cardiomyopathy10.1
44berger disease10.0C4A, ALB
45atherosclerosis10.0HMOX1, ALB, PI3
46sudden infant death syndrome10.0C4A, CAV3
47nephritis9.9C4A, ALB
48primary hyperoxaluria9.9C4A, HMOX1, ALB
49sepsis9.8C4A, HMOX1, ALB, PI3

Graphical network of the top 20 diseases related to Hepatopulmonary Syndrome:



Diseases related to hepatopulmonary syndrome

Symptoms for Hepatopulmonary Syndrome

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Drugs & Therapeutics for Hepatopulmonary Syndrome

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Drug clinical trials:

Search ClinicalTrials for Hepatopulmonary Syndrome

Search NIH Clinical Center for Hepatopulmonary Syndrome

Genetic Tests for Hepatopulmonary Syndrome

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Anatomical Context for Hepatopulmonary Syndrome

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MalaCards organs/tissues related to Hepatopulmonary Syndrome:

32
Liver, Lung, Endothelial, Brain, Bone marrow, Bone, Smooth muscle, Skin, Testes, Monocytes

Animal Models for Hepatopulmonary Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Hepatopulmonary Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6CAV3, ALB, HMOX1, HTR2B, KCNA5
2MP:00053858.5GDF2, KCNA5, HTR2B, CAV3, HMOX1
3MP:00053708.5HMOX1, BHMT, NR0B2, ALB
4MP:00053767.8CAV3, ALB, NR0B2, BHMT, HMOX1, KCNA5

Publications for Hepatopulmonary Syndrome

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Articles related to Hepatopulmonary Syndrome:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
Successful resolution of very severe hepatopulmonary syndrome following adult-to-adult living donor liver transplantation: Report of two cases. (25355534)
2014
2
Are the spider angiomas skin markers of hepatopulmonary syndrome? (24322187)
2013
3
Pharmacological treatment for hepatopulmonary syndrome. (24102057)
2013
4
Hepatopulmonary syndrome and liver transplantation: who, when, and where? (23471874)
2013
5
Detection of hepatopulmonary syndrome in patients with liver cirrhosis using 3D contrast echocardiography. (22560819)
2012
6
Effects of caffeic acid phenethyl ester (CAPE) on hepatopulmonary syndrome. (21046212)
2011
7
Physiopathological, clinical and therapeutic aspects of hepatopulmonary syndrome. (20589345)
2010
8
Attenuation of experimental hepatopulmonary syndrome in endothelin B receptor-deficient rats. (19196949)
2009
9
Sarcoidosis complicated by cirrhosis and hepatopulmonary syndrome. (18437252)
2008
10
Current concepts in the management of hepatopulmonary syndrome. (19183751)
2008
11
Pentoxifylline therapy for hepatopulmonary syndrome: a pilot study. (18779471)
2008
12
Value of contrast echocardiography for the diagnosis of hepatopulmonary syndrome. (17011830)
2007
13
Successful liver retransplantation for recurrent hepatopulmonary syndrome. (17976130)
2007
14
Hepatopulmonary syndrome. (17722431)
2007
15
Clinical controversies surrounding the diagnosis and treatment of hepatopulmonary syndrome. (17464272)
2007
16
Congenital portocaval fistula associated with hepatopulmonary syndrome: ligation vs liver transplantation. (16481229)
2006
17
Liver transplantation of a child with child a cirrhosis and severe hepatopulmonary syndrome. (16797324)
2006
18
Effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome. (16688838)
2006
19
Hepatopulmonary syndrome can show spontaneous resolution: possible mechanism of portopulmonary hypertension overlap? (16423214)
2006
20
Natural history of hepatopulmonary syndrome: Impact of liver transplantation. (15828054)
2005
21
Estrogen promotes intrapulmonary vasodilatation in hepatopulmonary syndrome. (16024287)
2005
22
Congenital absence of portal vein presenting as hepatopulmonary syndrome. (15670231)
2005
23
The hepatopulmonary syndrome: NO way out? (15176675)
2004
24
Case report of unchanged tacrolimus clearance in a hypoxemic pediatric liver transplant recipient with hepatopulmonary syndrome. (15502939)
2004
25
Severe polycythemia as the first clinical presentation of hepatopulmonary syndrome. (12811222)
2003
26
Liver transplantation for hepatopulmonary syndrome: a ten-year experience in Paris, France. (12792501)
2003
27
Hepatopulmonary syndrome in noncirrhotic portal hypertensive patients. (12757170)
2003
28
Case 63: hepatopulmonary syndrome. (14519870)
2003
29
Hepatopulmonary syndrome. (12421031)
2002
30
Biliary cyst fluid from common bile duct-ligated rats stimulates endothelial nitric oxide synthase in pulmonary artery endothelial cells: a potential role in hepatopulmonary syndrome. (11230754)
2001
31
Methylene blue improves the hepatopulmonary syndrome. (11529704)
2001
32
Prevalence of hepatopulmonary syndrome in cirrhosis and extrahepatic portal venous obstruction. (11774955)
2001
33
Hepatopulmonary Syndrome and Portopulmonary Hypertension. (11696280)
2001
34
Hepatopulmonary syndrome in noncirrhotic portal hypertension. (10836927)
2000
35
Hepatopulmonary Syndrome and Liver Transplantation. (10648589)
2000
36
Portal hypertension and hepatopulmonary syndrome in a middle-aged man with hepatitis B infection. (11076405)
2000
37
Hepatopulmonary syndrome: a prospective study of relationships between severity of liver disease, PaO(2) response to 100% oxygen, and brain uptake after (99m)Tc MAA lung scanning. (10988181)
2000
38
Methylene blue improves the hepatopulmonary syndrome. (11074903)
2000
39
Hepatopulmonary syndrome in Gaucher disease with right-to-left shunt: evaluation and measurement using Tc-99m MAA. (10069725)
1999
40
Late recurrence and rapid evolution of severe hepatopulmonary syndrome after liver transplantation. (10477847)
1999
41
Localizing intrapulmonary shunt in hepatopulmonary syndrome by transesophageal echocardiography. (10506859)
1999
42
Pulmonary hypertension following hepatopulmonary syndrome in a patient with cirrhosis. (10453952)
1999
43
Hepatopulmonary syndrome after allogeneic bone marrow transplantation. (10642817)
1999
44
Hepatopulmonary syndrome associated with sarcoidosis of the liver: case report. (9879271)
1998
45
Severe pulmonary hypertension and amelioration of hepatopulmonary syndrome after liver transplantation. (9516572)
1998
46
Diagnosis of hepatopulmonary syndrome with contrast transthoracic echocardiography and histological confirmation. (9766826)
1998
47
Hepatopulmonary syndrome and radionuclide lung perfusion imaging. (9712400)
1998
48
Hepatopulmonary syndrome: the paradigm of liver-induced hypoxaemia. (9395754)
1997
49
Elevated exhaled nitric oxide in patients with hepatopulmonary syndrome. (8620957)
1995
50
The hepatopulmonary syndrome masquerading as pulmonary Langerhans-cell histiocytosis. Hepatopulmonary Syndrome Study Group. (8198345)
1994

Variations for Hepatopulmonary Syndrome

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Expression for genes affiliated with Hepatopulmonary Syndrome

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Expression patterns in normal tissues for genes affiliated with Hepatopulmonary Syndrome

Search GEO for disease gene expression data for Hepatopulmonary Syndrome.

Pathways for genes affiliated with Hepatopulmonary Syndrome

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Compounds for genes affiliated with Hepatopulmonary Syndrome

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Compounds related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1auranofin28 44 61 1113.2HMOX1, ALB
2Bilirubin2410.2ALB, HMOX1
3isoflurane50 44 1112.2HMOX1, ALB
4propofol44 50 1112.1HMOX1, ALB
5clomipramine44 50 1112.1HTR2B, ALB
6fluoxetine44 50 28 1113.0ALB, HTR2B
7polyethylene glycol449.9HMOX1, ALB
8olanzapine44 50 28 24 1113.9HTR2B, ALB
9vitamin b6449.8BHMT, ALB
10salicylic acid44 2810.8HMOX1, ALB
11vitamin b12449.7BHMT, ALB
12histamine44 28 2411.6PI3, ALB, HMOX1
13fatty acid449.1ALB, CAV3, PI3
14nitric oxide44 24 1111.0PI3, HTR2B, CAV3, HMOX1
15glucose449.0GDF2, CAV3, ALB, NR0B2
16cysteine449.0HMOX1, BHMT, ALB, PI3
17oxygen44 249.4PI3, KCNA5, HTR2B, HMOX1, C4A
18lipid448.4PI3, CAV3, ALB, NR0B2
19calcium44 50 24 1110.9NR0B2, ALB, CAV3, HTR2B, CELA1, KCNA5

GO Terms for genes affiliated with Hepatopulmonary Syndrome

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Cellular components related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Z discGO:0300189.5CAV3, KCNA5
2caveolaGO:0059019.2HMOX1, CAV3, KCNA5
3protein complexGO:0432348.8BHMT, NR0B2, ALB

Biological processes related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of angiogenesisGO:0457669.8HMOX1, GDF2
2negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.8HMOX1, NR0B2
3cellular iron ion homeostasisGO:0068799.7GDF2, HMOX1
4regulation of membrane potentialGO:0423919.5KCNA5, CAV3
5positive regulation of endothelial cell proliferationGO:0019389.5HTR2B, GDF2

Molecular functions related to Hepatopulmonary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.8ALB, HTR2B
2potassium channel inhibitor activityGO:0198709.5CAV3, KCNA5
3endopeptidase inhibitor activityGO:0048668.8C4A, PI3
4protein complex bindingGO:0324038.8BHMT, NR0B2, CAV3

Products for genes affiliated with Hepatopulmonary Syndrome

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Sources for Hepatopulmonary Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet