Hepatopulmonary Syndrome malady

Wikipedia: In medicine, hepatopulmonary syndrome is a syndrome of shortness of breath and hypoxemia (low oxygen...⁴⁴ more...

MalaCards: Hepatopulmonary Syndrome, also known as hepatopulmonary syndrome (disorder), is related to hypertension and pulmonary hypertension. An important gene associated with Hepatopulmonary Syndrome is HMOX1 (heme oxygenase (decycling) 1), and among its related pathways are EGFR Inhibitor Pathway, Pharmacodynamics and Bacterial infections in CF airways. The compounds glucose and nadph have been mentioned in the context of this disorder. Affiliated tissues include liver and lung, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Aliases & Descriptions:

hepatopulmonary syndrome 6 8 32 43 hepatopulmonary syndrome (disorder) 6

Diseases related to hepatopulmonary syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 870)

id	Related Disease	Score	Top Affiliating Genes
1	hypertension	31.2	NOS2, NOS3, ACE, ROCK2
2	pulmonary hypertension	28.8	BMPR1A, BMPR2, ANGPT1, CAV1, TPH1, TNC
3	hepatitis	28.1	XDH, F2, ALB, SMAD3, TGFB1
4	gaucher's disease	28.1	MTHFR, CCL2, F9, F2, ESR2, TNF
5	hepatitis a	27.3	F9, F2, ALB, TNF, ACE, TGFB1
6	pulmonary function	25.9	MPO, CD14, F2, ALB, TNF, CRP
7	pulmonary arteriovenous malformation	13.9	ENG, ALB, HMOX1, HIF1A
8	telangiectasis	13.9	BMPR2, ENG, SMAD4, ACVRL1, ELN
9	bilirubin metabolic disorder	13.8	F9, F2, ALB, HMOX1
10	netherton syndrome	13.8	PI3, EDNRA, ELANE, GBA
11	optic nerve disease	13.8	PDE5A, EDN1, EDNRB, ELN
12	arteriovenous malformation	13.8	ENG, SMAD4, ACVRL1
13	pasteurellosis	13.8	PI3, MPO, ALB, ELANE
14	homocystinuria	13.7	BHMT, MTHFR, ALB, CBS, THBD
15	connective tissue disease	13.7	BMPR2, EDN1, EDNRA, ACVRL1, ELN
16	sorsby fundus dystrophy	13.7	MMP3, MMP9, ELN
17	exfoliation syndrome	13.7	EDNRA, EDNRB, ELN
18	portal hypertension	13.7	BMPR2, F2, ALB, NOS3, EDN1, EDNRA
19	diffuse astrocytoma	13.7	CDKN2A, AKT1, TNC, EDNRA, ECE1
20	pre-eclampsia	13.7	NOS3, EDN1, EDNRA
21	dysfibrinogenemia	13.6	F2, ALB, PLAT, THBD
22	acute poststreptococcal glomerulonephritis	13.6	CCL2, ALB, PLG, EDN1, EDNRB, NPPA
23	actinic keratosis	13.6	CDKN2A, MMP2, MMP3, ALB, TNC
24	central sleep apnea	13.6	NOS3, NPPA, NPPB
25	chronic rhinitis	13.6	MPO, EDN1, ECE1
26	placental abruption	13.6	BHMT, MTHFR, ENG, F2, NOS3, THBD
27	intraocular melanoma	13.6	CDKN2A, MMP2, ENG, SMAD4, PLG, THBS1
28	neonatal stroke	13.6	SERPINE1, MTHFR, ALB
29	peutz-jeghers syndrome	13.6	BMPR1A, CYP19A1, SMAD2, SMAD4, HIF1A, PRKCG
30	impotence	13.6	NOS2, NOS3, PDE5A, SHBG, EDN1, EDNRA
31	intracranial thrombosis	13.6	F2, PLAT, PLG
32	orofacial cleft	13.5	RARA, BHMT, MTHFR, CBS, NOS3
33	aortic valve stenosis	13.5	TNC, ELN, NPPA, NPPB
34	hemorrhoid	13.5	MMP9, F2, NOS2
35	chronic granulomatous disease	13.5	MPO, AKT1, CYBB, NOX1, SOD1
36	patent foramen ovale	13.5	MTHFR, F2, PLAT, EDNRA
37	conjunctivochalasis	13.5	MMP2, MMP3, MMP9, PLAU
38	spontaneous pneumothorax	13.5	LBP, ELANE, SOD1
39	neural tube defect	13.5	RARB, BHMT, MTHFR, CCL2, F2, CBS
40	biliary tract disease	13.5	NR1H4, NR1I2, SOD1
41	newborn respiratory distress syndrome	13.5	PI3, LBP, MPO, ANGPT1, PLG, NOS2
42	extrinsic allergic alveolitis	13.4	PI3, CCL2, ELANE, SOD2
43	lacrimal duct obstruction	13.4	XDH, MMP3, HMOX1, PDE5A, EDNRB, ELN
44	thromboangiitis obliterans	13.4	SERPINE1, PLAT, NOS3, EDN1
45	factor xi deficiency	13.4	VWF, F9, F2, THBD
46	heparin-induced thrombocytopenia	13.4	SERPINE1, MTHFR, F2, ALB, THBD
47	congenital heart defect	13.4	BMPR2, MTHFR, ENG, TNC, NPPA, NPPB
48	steroid-resistant nephrotic syndrome	13.4	RELA, CCL2, F9, ALB, ACE
49	hemorrhagic disease	13.4	VWF, F9, F2, THBD
50	hepatocellular carcinoma (fibrolamellar variant)	13.4	MMP2, MMP9, PLAU

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hepatopulmonary syndrome:

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MGI Mouse Phenotypes related to hepatopulmonary syndrome:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.3	RUNX1, SOD2, ACVRL1, SMAD4, ENG, BMPR1A
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	TLR2, EDNRA, DUOX2, CAV1, XDH, RARG
3	respiratory system phenotype	MP:0005388	10.2	ACVRL1, NFKB2, TPH2, TPH1, CBS, IKZF1
4	embryogenesis phenotype	MP:0005380	10.1	ACVRL1, TIE1, RUNX1, ROCK2, ECE1, EDNRB
5	craniofacial phenotype	MP:0005382	10.0	ECE1, ACVRL1, EDNRB, EDNRA, EDN1, NFKB2
6	integument phenotype	MP:0010771	9.6	GBA, RUNX1, SLC6A4, PRKCG, TIE1, TLR2
7	pigmentation phenotype	MP:0001186	9.5	SOD2, EDNRB, CYP19A1, CCL2, APOE, CDKN2A
8	other phenotype	MP:0005395	9.1	NOS2, NOS3, COL18A1, TLR2, SOD2, ESR2
9	liver/biliary system phenotype	MP:0005370	8.8	GBA, RUNX1, SLC10A2, SOD1, TLR2, HIF1A
10	renal/urinary system phenotype	MP:0005367	8.5	NPPA, SOD2, THBS1, TIE1, HIF1A, CAV1
11	hearing/vestibular/ear phenotype	MP:0005377	8.1	PLAT, PLAU, NFKB1, EDN1, EDNRA, EDNRB
12	no phenotypic analysis	MP:0003012	7.9	RUNX1, EDNRB, NOX4, SMAD2, NR1I2, NR1H4
13	limbs/digits/tail phenotype	MP:0005371	7.8	CBS, ESR1, ESR2, SMAD3, EDNRB, THBS1
14	immune system phenotype	MP:0005387	7.6	GBA, ECE1, RUNX1, SOD2, PRKCB, PRKCG
15	reproductive system phenotype	MP:0005389	7.4	NR1I2, NR0B2, DUOX2, TNF, ESR2, AKT1
16	normal phenotype	MP:0002873	7.2	EDNRA, NFKB1, SMAD4, SMAD2, NR0B2, PPARG
17	behavior/neurological phenotype	MP:0005386	6.9	APOE, RARB, BMPR1A, SERPINE2, RBPJ, CCL2
18	nervous system phenotype	MP:0003631	6.6	ACVRL1, EDNRB, EDNRA, EDN1, NOX4, PLG
19	growth/size phenotype	MP:0005378	6.2	PLAT, CAV2, CBS, HTR2B, IKZF1, ANGPT1
20	skeleton phenotype	MP:0005390	6.1	HTR2B, VEGFA, RELA, BMPR1A, BMPR2, MMP9
21	adipose tissue phenotype	MP:0005375	6.0	SOD2, TPH2, TPH1, ESR2, ESR1, AKT1
22	digestive/alimentary phenotype	MP:0005381	6.0	SMAD3, RARB, RARA, RARG, VEGFA, RBPJ
23	vision/eye phenotype	MP:0005391	5.5	MMP2, CDKN2A, MTHFR, BAX, RARB, RARA
24	tumorigenesis	MP:0002006	5.4	TGFB1, THBS1, TLR2, HIF1A, ELANE, ACE
25	mortality/aging	MP:0010768	5.3	PLAU, CBS, F2, HTR2B, F9, IKZF1
26	cellular phenotype	MP:0005384	2.9	NOS2, HMOX1, ESR2, ESR1, AKT1, CAV1
27	muscle phenotype	MP:0005369	2.5	ECE1, SLC6A4, NPPB, NPPA, SOD2, SOD1
28	cardiovascular system phenotype	MP:0005385	0.8	THBD, NOS3, NOS2, PLG, PLAU, PLAT
29	homeostasis/metabolism phenotype	MP:0005376	-0.4	NR1I2, HMOX1, ESR2, ESR1, AKT1, CAV1

Articles related to hepatopulmonary syndrome:

(show all 19)

id	Title	Authors	Year	Affiliating Genes
1	Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease. (20346360)	Roberts K.E.... Fallon M.B.	2010	AKT1, MMP3, SOD1
2	Cyanosis revealing hepatopulmonary syndrome in a chil d with dyskeratosis congenita. (19953657)	Renoux M.C.... Counil F.	2010	ALB
3	Clinical significance of a myeloperoxidase gene polym orphism and inducible nitric oxide synthase expression in cirrhotic patients wi th hepatopulmonary syndrome. (20714866)	Wang Y.... Yang D.	2010	MPO
4	Significance of lipopolysaccharides, toll-like recep tor and inducible nitric oxide synthase in hepatopulmonary syndrome (19953876)	Yi H.M.... Chen G.H.	2009	TLR2, NOS2
5	Resolution of hepatopulmonary syndrome after ligation of a portosystemic shunt in a pediatric patient with an Abernethy malformation . (18280268)	Morikawa N.... Kawasaki K.	2008	EDN1
6	Mcp-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in hepatopulmonary syndrome. (17934860)	Tumgor G.... Aydogdu S.	2008	PLAU, PLAT, SERPINE1
7	Hepatopulmonary syndrome and portopulmonary hypertension: what's new? (17715635)	Colle I.... Van Vlierberghe H.	2007	NOS3
8	Deleterious effect of nitric oxide inhibition in chronic hepatopulmonary syndrome. (17353701)	Almeida J.A.... Thomas P.S.	2007	ALB
9	Evaluation of intrapulmonary vascular dilatations with high-resolution computed thorax tomography in patients with hepatopulmonary syndrome. (16340638)	KAPksal D.... Sahin B.	2006	ALB
10	Recent advances in hepatopulmonary syndrome. (16323392)	Wang Y.W.... Lin H.C.	2005	ALB
11	Carboxyhemoglobin levels in cirrhotic patients with a nd without hepatopulmonary syndrome. (15685544)	Arguedas M.R.... Fallon M.B.	2005	HMOX1
12	Transient hepatopulmonary syndrome in a patient with acute hepatitis A. (11155156)	Regev A.... Schiff E.R.	2001	F2, ALB
13	Significance of lung perfusion scanning with technet ium labeled macroaggregated albumin and pulmonary function assay for diagnosis of early hepatopulmonary syndrome (11782297)	Zhang H.... Fan D.	2001	ALB
14	Pulmonary hypertension following hepatopulmonary syndrome in a patient with cirrhosis. (10453952)	Mal H.... Fournier M.	1999	ALB
15	Hepatopulmonary syndrome (10544613)	Glattki G.P.... Costabel U.	1999	ALB
16	Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: a new approach. (9453490)	Abrams G.A.... Fallon M.B.	1998	ALB
17	Hepatopulmonary syndrome (9549117)	de Oliveira M.L.... Abecasis P.	1997	ALB
18	Pulmonary hypertension developing after alglucerase therapy in two patients with type 1 Gaucher disease complicated by the hepatopulmonary syndrome. (8967670)	Dawson A.... Beutler E.	1996	GBA
19	Hypoxemia in a cirrhotic patient caused by hepatopulmonary syndrome: a case report. (8828259)	Jan J.S.... Chen T.C.	1996	ALB

Genes related to hepatopulmonary syndrome according to GeneCards:

(show top 50)    (show all 106)

id	Symbol	Description	Score	GeneCards Section Context
1	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
2	ALB	albumin	11.0	Publications
3	TARM1	T cell-interacting, activating receptor on myeloid cells 1	11.0
4	GDF2	growth differentiation factor 2	11.0	Publications
5	CELA1	chymotrypsin-like elastase family, member 1	11.0	Publications
6	HTR2B	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled	11.0	Publications
7	PI3	peptidase inhibitor 3, skin-derived	11.0	Publications
8	DUOX2	dual oxidase 2	11.0	Publications
9	NR0B2	nuclear receptor subfamily 0, group B, member 2	11.0	Publications
10	SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	11.0	Publications
11	KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	11.0	Publications
12	BHMT	betaine--homocysteine S-methyltransferase	11.0	Publications
13	PAOX	polyamine oxidase (exo-N4-amino)	11.0
14	IKZF1	IKAROS family zinc finger 1 (Ikaros)	11.0	Publications
15	RARG	retinoic acid receptor, gamma	11.0	Publications
16	TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	11.0	Publications
17	DUOX1	dual oxidase 1	11.0	Publications
18	SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	11.0	Publications
19	NOX1	NADPH oxidase 1	11.0	Publications
20	CAV3	caveolin 3	11.0	Publications
21	C4A	complement component 4A (Rodgers blood group)	11.0	Publications
22	CAV2	caveolin 2	11.0	Publications
23	ACVRL1	activin A receptor type II-like 1	11.0	Publications
24	LBP	lipopolysaccharide binding protein	11.0	Publications
25	PTGIS	prostaglandin I2 (prostacyclin) synthase	11.0	Publications
26	SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	11.0	Publications
27	PRKCG	protein kinase C, gamma	11.0	Publications
28	NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	11.0	Publications
29	CYBB	cytochrome b-245, beta polypeptide	11.0	Publications
30	SMOX	spermine oxidase	11.0
31	S100A4	S100 calcium binding protein A4	11.0	Publications
32	TPH1	tryptophan hydroxylase 1	11.0	Publications
33	GBA	glucosidase, beta, acid	11.0	Publications
34	CBS	cystathionine-beta-synthase	11.0	Publications
35	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	11.0	Publications
36	TPH2	tryptophan hydroxylase 2	11.0	Publications
37	EDNRB	endothelin receptor type B	11.0	Publications
38	COL18A1	collagen, type XVIII, alpha 1	11.0	Publications
39	ENG	endoglin	11.0	Publications
40	NR1H4	nuclear receptor subfamily 1, group H, member 4	11.0	Publications
41	ECE1	endothelin converting enzyme 1	11.0	Publications
42	NR1I2	nuclear receptor subfamily 1, group I, member 2	11.0	Publications
43	ROCK2	Rho-associated, coiled-coil containing protein kinase 2	11.0	Publications
44	PLG	plasminogen	11.0	Publications
45	PDE5A	phosphodiesterase 5A, cGMP-specific	11.0	Publications
46	THBS1	thrombospondin 1	11.0	Publications
47	BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	11.0	Publications
48	BMPR1A	bone morphogenetic protein receptor, type IA	11.0	Publications
49	F9	coagulation factor IX	11.0	Publications
50	TNC	tenascin C	11.0	Publications

Pathways related to hepatopulmonary syndrome according to GeneDecks:

(show top 50)    (show all 119)

id	Pathway	Score	Top Affiliating Genes
1	EGFR Inhibitor Pathway, Pharmacodynamics34	10.7	NFKB2
2	Bacterial infections in CF airways41	10.7	LBP, NFKB2, RELA, TLR2
3	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.4	CD14, NFKB2, LBP
4	Immune response_Bacterial infections in normal airways41	10.4	RELA, CD14, NOS2, NFKB2, LBP
5	Endothelin-1 Signaling Pathway36	10.2	EDNRB, ECE1, ANGPT1, EDN1, PRKCA, PRKCG
6	Transcription NF-kB signaling pathway10	10.2	NFKB2, NFKB1, AKT1, CD14, LBP, RELA
7	Cell adhesion_Cell-matrix glycoconjugates41	10.1	PLG, MMP9, ELANE, ELN, TNC, MMP3
8	Focal adhesion20	10.1	ROCK2, PRKCA, PRKCG, THBS1, TNC, AKT1
9	Development VEGF signaling and activation10	10.0	NFKB1, PRKCB, PRKCG, NFKB2, AKT1, RELA
10	Blood Coagulation Signaling Pathways37	9.9	SERPINE1, PLAT, VWF, F9, PLAU, PLG
11	Complement and coagulation cascades20	9.9	F9, SERPINE1, PLG, C4A, THBD, PLAT
12	Leukocyte transendothelial migration20	9.9	PRKCB, MMP9, PRKCG, NOX1, CYBB, MMP2
13	TGF-beta/Smad Signaling3	9.9	SMAD3, SMAD4, SMAD2, BMPR2, ENG, TGFB1
14	Development_EGFR signaling pathway41	9.9	PRKCA, NFKB2, PRKCB, PRKCG, AKT1, MMP9
15	Cell adhesion ECM remodeling10	9.9	MMP9, PLAT, MMP2, PLAU, PLG, SERPINE2
16	Cell adhesion_ECM remodeling41	9.9	MMP2, SERPINE1, SERPINE2, MMP3, MMP9, PLAT
17	UPA-UPAR Pathway36	9.8	PLG, ELN, SERPINE1, MMP2, MMP3, MMP9
18	Development Angiopoietin - Tie2 signaling10	9.7	RELA, TIE1, NFKB2, NFKB1, AKT1, ANGPT1
19	Cell adhesion_PLAU signaling41	9.7	SERPINE2, SERPINE1, PLAT, PLAU, PLG, AKT1
20	Transcription_NF-kB signaling pathway41	9.7	RELA, TNF, NFKB1, CD14, AKT1, LBP
21	Angiogenesis3	9.6	TGFB1, HMOX1, NOS3, MMP9, MMP2, HIF1A
22	Cytokine production by Th17 cells in CF (Mouse model)41	9.6	CD14, TGFB1, NFKB2, NFKB1, SMAD4, LBP
23	Cell adhesion PLAU signaling10	9.6	PLG, PLAU, SERPINE1, SERPINE2, PLAT
24	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	9.5	SOD2, ESR1, RELA, BAX, NFKB1, ESR2
25	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	9.5	RELA, BAX, ESR1, ESR2, NFKB1, SOD2
26	Development TGF-beta receptor signaling10	9.5	TGFB1, RELA, SERPINE1, SMAD2, CAV1, SMAD4
27	Development_TGF-beta receptor signaling41	9.5	SMAD2, TGFB1, NFKB2, SMAD4, SMAD3, CAV1
28	Transendothelial Migration of Leukocytes36	9.5	PRKCA, CYBB, MMP2, MMP3, COL18A1, NOX1
29	TGF-beta signaling pathway20	9.4	ROCK2, SMAD2, SMAD3, TNF, BMPR2, BMPR1A
30	Immune response_MIF in innate immunity response41	9.3	RELA, LBP, TNF, CD14, NOS2, NFKB1
31	Chronic myeloid leukemia20	9.3	RUNX1, TGFB1, NFKB1, SMAD4, SMAD3, AKT1
32	Immune response IL-1 signaling pathway10	9.3	NOS2, TNF, NFKB1, HMOX1, SERPINE1, RELA
33	Immune response MIF in innate immunity response10	9.3	TNF, NFKB1, NOS2, CD14, LBP, RELA
34	Immune response_IL-1 signaling pathway41	9.3	RELA, SERPINE1, EDN1, NFKB1, NOS2, TNF
35	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.3	PRKCA, PRKCB, PRKCG, SMAD3, CYP19A1, TNF
36	Amoebiasis20	9.2	PRKCB, PRKCA, TLR2, NOS2, TGFB1, CD14
37	Molecular Mechanisms of Cancer36	9.1	BAX, RARB, RARA, CDKN2A, BMPR2, ANGPT1
38	Factors Promoting Cardiogenesis in Vertebrates36	9.0	NOX4, TGFB1, PRKCG, NPPA, NPPB, BMPR1A
39	Development VEGF signaling via VEGFR2 - generic cascades10	8.9	NOS3, RELA, VEGFA, AKT1, CCL2, NFKB1
40	Osteoclast differentiation20	8.9	CYBB, TNF, NFKB1, PPARG, NOX1, TGFB1
41	NF-KappaB Family Pathway36	8.7	GDF2, AKT1, RELA, NFKB1, TNF, NFKB2
42	Development_VEGF signaling and activation41	8.7	RELA, VEGFA, AKT1, ESR1, NFKB1, NFKB2
43	Antioxidant Action of Vitamin-C36	8.5	BMPR2, NOX4, BMPR1A, TGFB1, BAX, PRKCG
44	TGF-beta Signaling Pathways37	8.5	ESR2, ROCK2, RUNX1, TGFB1, NFKB2, NFKB1
45	Leishmaniasis20	8.5	NOS2, RELA, TNF, NFKB1, TLR2, TGFB1
46	Tuberculosis20	8.5	TGFB1, CD14, RELA, BAX, AKT1, NOS2
47	Tec Kinases Signaling36	8.5	CCL2, GDF2, NFKB1, ACVRL1, TLR2, TGFB1
48	Development_VEGF signaling via VEGFR2 - generic cascades41	8.4	PRKCG, PRKCA, PRKCB, NFKB1, CCL2, PLAU
49	Chagas disease (American trypanosomiasis)20	8.0	RELA, SERPINE1, CCL2, TNF, SMAD2, SMAD3
50	Pathways in cancer20	7.6	AKT1, PRKCG, TGFB1, HIF1A, NFKB2, NOS2

Compounds related to hepatopulmonary syndrome according to GeneDecks:

(show top 50)    (show all 480)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.7	CYBB, SMAD4, PLG, NOX4, TIE1, GDF2
2	nadph32 18	11.5	HTR2B, AKT1, NOX1, NOX4, HIF1A
3	nicotine32 34 9 9	13.3	PRKCA
4	egcg32	10.3	EDNRA, ELANE, PRKCA, SOD1
5	apocynin32	9.9	XDH, MPO, CYBB, NOS2, NOX1, NOX4
6	dmso32	9.9	XDH, MMP3, TPH1, CYBB, NR1I2, EDNRB
7	sodium nitroprusside32	9.5	VWF, HMOX1, TPH1, PDE5A, EDNRA, ELANE
8	l-nmma32	9.3	XDH, PPARG, NOS2, EDN1, EDNRA, SOD1
9	h2o232	9.3	VWF, KCNA5, XDH, MPO, APOE, F9
10	heparin32 9 18 9	12.2	VWF, SERPINE2, SERPINE1, LBP, MPO, MMP3
11	raloxifene32 9 9	10.8	VWF, SERPINE1, CCL2, ESR1, ESR2, CYP19A1
12	n acetylcysteine32	8.7	VWF, CDKN2A, MMP2, MMP3, MMP9, APOE
13	calcium32 9 18 9	11.7	PI3, RELA, VWF, SERPINE2, RARA, KCNA5
14	pge232	8.6	CD14, MMP3, HMOX1, PTGIS, CYP19A1, PPARG
15	fibrinogen32	8.5	SERPINE1, LBP, CD14, ANGPT1, CCL2, F9
16	progesterone32 42 9 18 9	12.5	BMPR2, RARA, RARB, CDKN2A, ENG, CAV1
17	homocysteine32 18	9.5	VWF, SERPINE1, BHMT, LBP, CD14, APOE
18	kininogen32	8.3	VWF, SERPINE1, MPO, F9, F2, ALB
19	pdtc32	8.1	XDH, MMP2, MMP9, CCL2, HMOX1, TNF
20	testosterone32 9 18 9	11.0	RELA, RARA, RARB, MTHFR, CDKN2A, MMP2
21	folate32	7.9	VWF, RARA, BHMT, MTHFR, CDKN2A, MMP2
22	superoxide32 18	8.9	PI3, LBP, XDH, MPO, CD14, ANGPT1
23	alpha tocopherol32	7.9	RARB, MTHFR, XDH, MMP9, APOE, ALB
24	arginine32	7.8	VWF, BMPR2, RARA, RARB, XDH, CD14
25	candesartan32 9 9	9.8	SERPINE1, VEGFA, MMP2, CCL2, ALB, PPARG
26	cysteine32	7.7	PI3, RARA, RARB, MTHFR, XDH, CD14
27	chloramphenicol32 9 9	9.7	PI3, SERPINE1, RARA, RARB, MPO, CDKN2A
28	thymidine32 18	8.6	BMPR2, RARA, RARB, MTHFR, ANGPT1, F9
29	resveratrol32 9 18 9	10.5	VEGFA, BAX, XDH, CD14, MMP2, MMP9
30	tamoxifen32 34 9 9	10.5	VEGFA, RARA, BAX, APOE, CAV1, AKT1
31	diphenyleneiodonium32	7.5	VEGFA, XDH, MPO, CCL2, AKT1, TNF
32	alanine32	7.3	VWF, RARA, LBP, CD14, CDKN2A, MMP2
33	pd 98,05932	7.3	SERPINE1, RARA, BAX, CD14, MMP2, MMP3
34	8-isoprostane32	7.2	SERPINE1, XDH, MPO, MMP2, MMP9, CCL2
35	sb 20358032 42	8.2	PI3, VEGFA, MMP2, MMP3, MMP9, HMOX1
36	rosiglitazone32 9 18 9	10.1	SERPINE1, RARB, MMP2, MMP9, APOE, CCL2
37	ly29400232	6.9	PI3, VEGFA, RARA, MMP2, MMP9, ANGPT1
38	lactate32	6.7	VWF, XDH, MPO, CD14, MMP2, MMP3
39	cyclosporin a32 42	7.6	PI3, VWF, MTHFR, CD14, MMP3, MMP9
40	cholesterol32 9 18 9	9.5	VWF, SERPINE1, LBP, MTHFR, CD14, CDKN2A
41	atorvastatin32 34 9 18 9	10.5	VWF, VEGFA, MMP2, MMP9, APOE, CCL2
42	simvastatin32 34 42 9 18 9	11.5	VWF, SERPINE1, VEGFA, MMP3, MMP9, APOE
43	indomethacin32 9 9	8.4	MPO, MMP3, APOE, ALB, HMOX1, TNF
44	estrogen32	5.9	VWF, SERPINE1, RARG, RARA, RARB, MTHFR
45	creatinine32	5.7	VWF, LBP, MTHFR, MPO, CD14, CDKN2A
46	genistein32 9 18 9	8.7	SERPINE1, VEGFA, RARB, BAX, CDKN2A, MMP2
47	lipid32	5.6	PI3, SERPINE2, SERPINE1, BMPR2, RARA, RARB
48	actinomycin d32	5.2	SERPINE2, SERPINE1, VEGFA, RARA, RARB, BAX
49	prostacyclin32	4.8	VWF, SERPINE1, VEGFA, APOE, ANGPT1, CCL2
50	retinoic acid32 42 18	6.5	PI3, VWF, SERPINE1, RARG, RARA, RARB

Cellular components related to hepatopulmonary syndrome according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	caveola	GO:005901	10.5	NOS3, PTGIS, HMOX1, CAV1, CAV2, CAV3
2	SMAD protein complex	GO:071141	10.1	SMAD4, SMAD3, SMAD2
3	extracellular matrix	GO:031012	9.8	SOD1, THBS1, COL18A1, PLAT, TNC, SERPINE1
4	protein complex	GO:043234	9.7	SOD1, PRKCA, NR0B2, CAV1, CAV2, ALB
5	membrane raft	GO:045121	9.5	SLC6A4, PRKCA, EDNRA, TNF, CAV1, CAV2
6	platelet alpha granule lumen	GO:031093	9.3	TGFB1, THBS1, PLG, ALB, VEGFA, SERPINE1
7	external side of plasma membrane	GO:009897	9.2	THBS1, TLR2, ACE, TNF, ENG, VWF
8	neuronal cell body	GO:043025	9.1	SOD1, PRKCA, TGFB1, ACVRL1, CYP19A1, CCL2
9	proteinaceous extracellular matrix	GO:005578	8.8	TGFB1, ELN, TNC, MMP9, MMP3, MMP2
10	cell surface	GO:009986	8.0	PLAT, PLAU, ACVRL1, ELANE, TLR2, THBD
11	nucleoplasm	GO:005654	7.9	NR1H4, NR1I2, SMAD2, SMAD3, SMAD4, NFKB1
12	cytosol	GO:005829	7.0	NFKB1, NOS3, NOS2, SMOX, SMAD4, SMAD3
13	plasma membrane	GO:005886	6.6	TLR2, ACE, C4A, EDNRB, EDNRA, NOS3
14	extracellular region	GO:005576	5.6	COL18A1, PLG, PLAU, PLAT, CRP, TNC
15	extracellular space	GO:005615	5.3	GDF2, PTGIS, CRP, PLAT, PLAU, PLG
16	nucleus	GO:005634	5.0	NOX4, NOS3, NOS2, SMOX, SMAD4, SMAD3

Biological processes related to hepatopulmonary syndrome according to GeneDecks:

(show top 50)    (show all 108)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of BMP signaling pathway	GO:030513	10.5	SMAD4, GDF2, ACVRL1, BMPR2, ENG, SMAD2
2	superoxide anion generation	GO:042554	10.5	EDN1, NOX4, NOX1, CYBB, DUOX1, SOD1
3	vasoconstriction	GO:042310	10.5	HTR2B, SLC6A4, EDNRB, EDNRA, EDN1, CAV1
4	negative regulation of endothelial cell proliferation	GO:001937	10.5	XDH, APOE, ACVRL1, GDF2, ENG, CAV2
5	blood vessel remodeling	GO:001974	10.4	BAX, NOS3, ACVRL1, ELN, BMPR2, CBS
6	negative regulation of fibrinolysis	GO:051918	10.4	SERPINE1, F2, PLG, THBD, THBS1
7	negative regulation of platelet activation	GO:010544	10.3	THBD, F2, APOE, NOS3, SERPINE2
8	superoxide metabolic process	GO:006801	10.2	CYBB, NOS2, SOD2, NOX1, SOD1, CBS
9	negative regulation of blood coagulation	GO:030195	10.2	SERPINE2, SERPINE1, APOE, THBD, EDN1
10	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	10.1	BMPR2, SMAD4, ACVRL1, TGFB1, GDF2, ENG
11	extracellular matrix disassembly	GO:022617	10.1	MMP9, ELANE, MMP3, MMP2, PLG, ENG
12	in utero embryonic development	GO:001701	10.0	EDN1, NOS3, SMAD2, EDNRA, ACVRL1, BMPR1A
13	negative regulation of blood vessel endothelial cell migration	GO:043537	9.9	TGFB1, THBS1, APOE, ACVRL1, GDF2
14	positive regulation of nitric-oxide synthase activity	GO:051000	9.8	HIF1A, ESR1, AKT1, APOE, HTR2B
15	cellular response to interleukin-1	GO:071347	9.8	MMP9, RELA, CCL2, PTGIS, HIF1A, NFKB1
16	regulation of binding	GO:051098	9.8	SMAD3, SMAD2, SMAD4, TGFB1
17	response to estrogen stimulus	GO:043627	9.7	ESR1, HMOX1, PPARG, TPH2, CAV1, SERPINE1
18	regulation of transforming growth factor beta receptor signaling pathway	GO:017015	9.7	TGFB1, ENG, SMAD4, SMAD3, SMAD2
19	positive regulation of smooth muscle cell proliferation	GO:048661	9.6	ELANE, PRKCA, HIF1A, HMOX1, TNF, NOX1
20	transforming growth factor beta receptor signaling pathway	GO:007179	9.6	SMAD2, ACVRL1, TGFB1, SERPINE1, BMPR1A, ENG
21	positive regulation of endothelial cell proliferation	GO:001938	9.6	GDF2, HTR2B, ACVRL1, CCL2, BMPR2, VEGFA
22	positive regulation of endothelial cell migration	GO:010595	9.5	THBS1, EDN1, ANGPT1, VEGFA, PRKCA, BMPR2
23	fibrinolysis	GO:042730	9.4	PLAT, SERPINE1, F2, PLAU, PLG
24	regulation of blood pressure	GO:008217	9.4	HMOX1, PPARG, NOS3, EDNRB, NPPB, NPPA
25	lipopolysaccharide-mediated signaling pathway	GO:031663	9.3	TGFB1, LBP, CCL2, TNF, NOS3, TLR2
26	angiogenesis	GO:001525	9.2	TIE1, HMOX1, CCL2, HIF1A, ACVRL1, PRKCA
27	positive regulation of apoptotic process	GO:043065	9.2	MMP9, BAX, RARG, RARB, ESR2, TNF
28	positive regulation of blood vessel endothelial cell migration	GO:043536	9.2	TGFB1, PRKCA, AKT1, ANGPT1, VEGFA, THBS1
29	response to mechanical stimulus	GO:009612	9.2	TNF, NOS3, CCL2, MMP9, PRKCA, CAV1
30	platelet degranulation	GO:002576	9.2	PLG, THBS1, TGFB1, SOD1, VEGFA, SERPINE1
31	extracellular matrix organization	GO:030198	9.1	ELANE, MMP2, PLG, COL18A1, NFKB2, ELN
32	positive regulation of angiogenesis	GO:045766	9.1	PTGIS, HMOX1, MMP9, VEGFA, SERPINE1, NOS3
33	negative regulation of cell growth	GO:030308	9.0	PPARG, GDF2, NPPB, NPPA, ESR2, SERPINE2
34	negative regulation of apoptotic process	GO:043066	9.0	THBS1, ANGPT1, RELA, SERPINE1, VEGFA, SOD2
35	response to estradiol stimulus	GO:032355	9.0	NOS3, CYP19A1, ESR1, MMP9, RARA, TGFB1
36	anti-apoptosis	GO:006916	8.9	MPO, SOD1, RELA, ANGPT1, CCL2, AKT1
37	transcription initiation from RNA polymerase II promoter	GO:006367	8.9	ESR1, RARB, RARA, RARG, SERPINE1, RBPJ
38	positive regulation of MAP kinase activity	GO:043406	8.8	EDN1, VEGFA, HTR2B, TNF, NOX4, PDE5A
39	negative regulation of cell proliferation	GO:008285	8.7	NOS3, SMAD2, SMAD4, PLG, SOD2, PRKCA
40	positive regulation of protein phosphorylation	GO:001934	8.5	ENG, VEGFA, F2, TNF, AKT1, EDNRA
41	platelet activation	GO:030168	8.4	PRKCB, VWF, SERPINE1, PRKCA, VEGFA, F2
42	gene expression	GO:010467	8.4	PRKCA, PPARA, SMAD4, SMAD3, SMAD2, NR1I2
43	response to drug	GO:042493	8.3	SLC6A4, NPPB, SOD1, TGFB1, MMP9, CCL2
44	signal transduction	GO:007165	8.2	NOX1, PLAU, PPARG, TNC, ESR2, ESR1
45	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.2	RBPJ, CELA1, SMAD3, ENG, CAV1, ESR2
46	positive regulation of transcription, DNA-dependent	GO:045893	8.0	PPARA, SMAD2, SMAD3, SMAD4, NFKB1, ACVRL1
47	inflammatory response	GO:006954	7.8	NPPB, CELA1, TGFB1, TLR2, C4A, NFKB1
48	blood coagulation	GO:007596	7.3	SOD1, PRKCA, PRKCB, PLG, PRKCG, TGFB1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.5	PPARA, PPARG, TNF, RELA, RBPJ, SERPINE1
50	response to hypoxia	GO:001666	6.1	ECE1, SLC6A4, NPPB, TGFB1, THBS1, HIF1A

Molecular functions related to hepatopulmonary syndrome according to GeneDecks:

(show all 24)

id	Name	GO ID	Score	Top Affiliating Genes
1	NAD(P)H oxidase activity	GO:016174	10.6	NOX4, DUOX2, DUOX1
2	lipoteichoic acid binding	GO:070891	10.6	LBP, CD14, TLR2
3	transforming growth factor beta-activated receptor activity	GO:005024	10.6	ACVRL1, ENG, BMPR2, BMPR1A
4	retinoic acid receptor activity	GO:003708	10.5	RARB, RARA, RARG
5	retinoid X receptor binding	GO:046965	10.5	NR1H4, NR0B2, PPARG, RARG
6	nitric-oxide synthase binding	GO:050998	10.2	SLC6A4, CAV1, CAV3
7	modified amino acid binding	GO:072341	10.2	NOX4, CBS, MTHFR
8	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	10.0	ESR2, PPARG, PPARA, NR1H4, NR1I2
9	heme binding	GO:020037	9.9	CYP19A1, NOS2, NOS3, NOX4, CYBB, PTGIS
10	flavin adenine dinucleotide binding	GO:050660	9.9	XDH, CYBB, NOS2, NOS3, NOX4
11	drug binding	GO:008144	9.8	ACE, NR1I2, PPARA, PPARG, ALB, HTR2B
12	serine-type endopeptidase activity	GO:004252	9.8	ELANE, PLG, PLAU, PLAT, F2, F9
13	iron ion binding	GO:005506	9.8	NOS3, NOS2, CYP19A1, PTGIS, TPH2, TPH1
14	Gram-positive bacterial cell surface binding	GO:051637	9.7	TLR2, CRP, LBP
15	steroid hormone receptor activity	GO:003707	9.5	PPARA, NR0B2, NR1H4, NR1I2, PPARG, ESR2
16	heparin binding	GO:008201	9.3	THBS1, ELANE, CCL2, APOE, MPO, VEGFA
17	receptor binding	GO:005102	9.3	CAV1, TNC, NOS2, NPPA, NPPB, GBA
18	transcription regulatory region DNA binding	GO:044212	9.0	HIF1A, NFKB1, SMAD4, SMAD3, PPARG, TNF
19	enzyme binding	GO:019899	8.7	PRKCA, TGFB1, HIF1A, PPARG, HMOX1, ESR2
20	protein heterodimerization activity	GO:046982	8.6	RUNX1, TGFB1, TLR2, HIF1A, CYBB, APOE
21	identical protein binding	GO:042802	8.5	THBS1, SMAD4, TNF, ESR1, AKT1, APOE
22	sequence-specific DNA binding transcription factor activity	GO:003700	8.4	NR1H4, SMAD2, SMAD3, SMAD4, NFKB1, NFKB2
23	protein homodimerization activity	GO:042803	6.9	SMAD4, CRP, NOS2, NFKB1, SHBG, TGFB1
24	protein binding	GO:005515	1.7	GDF2, NFKB1, COL18A1, NOX1, NOS3, NOS2