MCID: HPT009
MIFTS: 48

Hepatopulmonary Syndrome malady

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Hepatopulmonary Syndrome

Aliases & Descriptions for Hepatopulmonary Syndrome:

Name: Hepatopulmonary Syndrome 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:900
ICD10 33 K76.81
ICD9CM 35 573.5
MeSH 42 D020065
SNOMED-CT 64 371067004
UMLS 69 C0600452

Summaries for Hepatopulmonary Syndrome

MalaCards based summary : Hepatopulmonary Syndrome is related to common variable immunodeficiency and proliferating trichilemmal cyst, and has symptoms including hemoptysis An important gene associated with Hepatopulmonary Syndrome is ALB (Albumin), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Carvedilol and Vasodilator Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and endothelial, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 71 In medicine, hepatopulmonary syndrome is a syndrome of shortness of breath and hypoxemia (low oxygen... more...

Related Diseases for Hepatopulmonary Syndrome

Diseases related to Hepatopulmonary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
id Related Disease Score Top Affiliating Genes
1 common variable immunodeficiency 29.2 NOS3 VEGFA
2 proliferating trichilemmal cyst 10.3 EDN1 NOS3
3 liver disease 10.3
4 congenital dyserythropoietic anemia 10.2 ALB TNF
5 vascular disease 10.2 ALB EDNRB
6 hepatitis 10.2
7 portal hypertension 10.2
8 poikiloderma with neutropenia 10.2 EDN1 NOS2 NOS3
9 krauss herman holmes syndrome 10.2 ALB EDNRA
10 lymphadenitis 10.2 EDN1 HMOX1 NOS3
11 viral hepatitis 10.2 EDN1 NOS2 NOS3
12 immunodeficiency, common variable, 8, with autoimmunity 10.1 EDN1 EDNRA
13 intracranial cysts 10.1 NOS3 VEGFA
14 liver cirrhosis 10.1
15 liver inflammatory pseudotumor 10.1 ALB NOS2 TNF
16 immunodeficiency by defective expression of hla class 1 10.1 EDNRA EDNRB
17 indeterminate leprosy 10.1 EDN1 NOS3
18 chromoblastomycosis 10.1 HMOX1 NOS2 TNF
19 paranasal sinus sarcoma 10.1 ALB EDN1 TNF
20 limb ischemia 10.1 EDN1 NOS3 TNF
21 submucous uterine fibroid 10.1 ALB VEGFA
22 diabetic encephalopathy 10.1 EDN1 NOS3 TNF
23 anogenital venereal wart 10.1 ALB EDN1 TNF
24 uterine ligament clear cell adenocarcinoma 10.1 ALB EDNRB TNF
25 calcinosis 10.1 ALB EDN1 TNF
26 esophagus carcinoma in situ 10.1 EDNRA EDNRB
27 hypersensitivity syndrome, carbamazepine-induced 10.1 ALB VEGFA
28 adenocarcinoma 10.1 EDN1 EDNRA EDNRB
29 endotheliitis 10.1
30 citrullinemia, type ii, neonatal-onset 10.1 ALB NOS3 VEGFA
31 ectodermal dysplasia 9, hair/nail type 10.0 EDN1 NOS3 VEGFA
32 skull base neoplasm 10.0 EDN1 EDNRA NOS3
33 histiocytoid hemangioma 10.0 ALB HMOX1 VEGFA
34 acute posterior multifocal placoid pigment epitheliopathy 10.0 EDN1 NOS3 VEGFA
35 nervous system disease 10.0 EDNRA EDNRB
36 idiopathic hypertrophic pachymeningitis 10.0 NOS2 TNF
37 welander distal myopathy 10.0 EDN1 NOS3 VEGFA
38 childhood malignant hemangiopericytoma 10.0 ALB EDNRB TNF
39 ovarian mucinous adenocarcinoma 10.0 AKT1 HMOX1 TNF
40 pyelonephritis 10.0 EDN1 NOS2 NOS3 TNF
41 senile atrophy of choroid 10.0 NOS2 VEGFA
42 ectodermal dysplasia bartalos type 10.0 NOS2 TNF VEGFA
43 pulmonary hypertension 10.0
44 capillary hemangioma 10.0 ALB EDN1 NOS3 VEGFA
45 peroneal neuropathy 9.9 AKT1 ALB NOS3 TNF
46 body dysmorphic disorder 9.9 AKT1 ALB NOS3 TNF
47 pulpitis 9.9 NOS2 TNF VWF
48 proctitis 9.9 AKT1 ALB VEGFA
49 budd-chiari syndrome 9.9
50 substance-induced psychosis 9.9 ALB NOS2 TNF VEGFA

Graphical network of the top 20 diseases related to Hepatopulmonary Syndrome:



Diseases related to Hepatopulmonary Syndrome

Symptoms & Phenotypes for Hepatopulmonary Syndrome

UMLS symptoms related to Hepatopulmonary Syndrome:


hemoptysis

MGI Mouse Phenotypes related to Hepatopulmonary Syndrome:

44 (show all 22)
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.3 EDNRB HMOX1 NOS2 NOS3 NR0B2 TNF
2 homeostasis/metabolism MP:0005376 10.3 VWF AKT1 ALB EDN1 EDNRA EDNRB
3 cardiovascular system MP:0005385 10.29 AKT1 EDN1 EDNRA EDNRB HMOX1 NOS2
4 cellular MP:0005384 10.28 AKT1 ALB EDNRA EDNRB HMOX1 NOS2
5 digestive/alimentary MP:0005381 10.27 ALB EDN1 EDNRA EDNRB NOS2 NOS3
6 growth/size/body region MP:0005378 10.25 AKT1 EDN1 EDNRA EDNRB HMOX1 NOS2
7 mortality/aging MP:0010768 10.22 AKT1 ALB EDN1 EDNRA EDNRB HMOX1
8 behavior/neurological MP:0005386 10.2 AKT1 EDNRA EDNRB HMOX1 NOS2 NOS3
9 immune system MP:0005387 10.16 AKT1 EDNRA EDNRB HMOX1 NOS2 NOS3
10 muscle MP:0005369 10.16 AKT1 ALB EDN1 EDNRA EDNRB HMOX1
11 hematopoietic system MP:0005397 10.14 AKT1 EDNRA HMOX1 NOS2 NOS3 TNF
12 liver/biliary system MP:0005370 10.1 AKT1 ALB HMOX1 NOS2 NOS3 NR0B2
13 nervous system MP:0003631 10.06 EDNRA EDNRB NOS2 NOS3 TNF VEGFA
14 craniofacial MP:0005382 10.05 EDN1 EDNRA EDNRB NOS2 TNF VEGFA
15 adipose tissue MP:0005375 10 AKT1 HMOX1 NOS2 NOS3 TNF
16 renal/urinary system MP:0005367 9.92 ALB EDN1 EDNRA EDNRB HMOX1 NOS2
17 neoplasm MP:0002006 9.91 AKT1 ALB EDNRB NOS2 TNF VEGFA
18 normal MP:0002873 9.91 AKT1 ALB EDN1 EDNRA NOS3 NR0B2
19 reproductive system MP:0005389 9.8 NOS2 NOS3 NR0B2 TNF VEGFA AKT1
20 respiratory system MP:0005388 9.76 EDNRA EDNRB HMOX1 NOS2 NOS3 TNF
21 skeleton MP:0005390 9.56 NOS2 NOS3 TNF VEGFA AKT1 EDN1
22 vision/eye MP:0005391 9.1 NOS2 NOS3 TNF VEGFA EDNRA EDNRB

Drugs & Therapeutics for Hepatopulmonary Syndrome

Drugs for Hepatopulmonary Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
2 Vasodilator Agents Phase 4,Phase 1
3 Polygeline Phase 4
4 Liver Extracts Phase 4,Phase 2,Phase 1
5 Adrenergic Agents Phase 4
6 Adrenergic Antagonists Phase 4
7 Adrenergic alpha-1 Receptor Antagonists Phase 4
8 Adrenergic alpha-Antagonists Phase 4
9 Neurotransmitter Agents Phase 4
10 Adrenergic beta-Antagonists Phase 4
11 Antihypertensive Agents Phase 4,Phase 2
12
Norfloxacin Approved Phase 2 70458-96-7 4539
13
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
14
Bosentan Approved, Investigational Phase 2 147536-97-8 104865
15
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
16
Nicotinamide Approved, Nutraceutical Phase 2 98-92-0 936
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
18 Anti-Bacterial Agents Phase 2
19 Anti-Infective Agents Phase 2
20 Cytochrome P-450 CYP1A2 Inhibitors Phase 2
21 Cytochrome P-450 Enzyme Inhibitors Phase 2
22 Topoisomerase Inhibitors Phase 2
23
Iodine Phase 2 7553-56-2 807
24 cadexomer iodine Phase 2
25 Nicotinic Acids Phase 2
26 Trace Elements Phase 2
27 Vitamin B Complex Phase 2
28 Vitamins Phase 2
29 Protein Kinase Inhibitors Phase 2
30 Micronutrients Phase 2
31 Endothelin Receptor Antagonists Phase 2
32 Folate Nutraceutical Phase 2
33 Vitamin B3 Nutraceutical Phase 2
34 Vitamin B9 Nutraceutical Phase 2
35
Pentoxifylline Approved, Investigational Phase 1 6493-05-6 4740
36 Phosphodiesterase Inhibitors Phase 1
37 Platelet Aggregation Inhibitors Phase 1
38 Protective Agents Phase 1
39 Radiation-Protective Agents Phase 1
40 Antioxidants Phase 1
41
Rifaximin Approved, Investigational 80621-81-4 6436173
42 rifamycin SV
43 Gastrointestinal Agents
44 Nucleic Acid Synthesis Inhibitors
45 Rifamycins

Interventional clinical trials:


id Name Status NCT ID Phase
1 Echocardiographic Assessment of Intrapulmonary Vasodilatation: Agitated Saline Versus Polygeline Unknown status NCT00343122 Phase 4
2 Early Precise Diagnosis and Intervention of CPT Based on a Noninvasive 3D-vHPS Recruiting NCT02925975 Phase 4
3 A Pilot Study of Norfloxacin for Hepatopulmonary Syndrome Completed NCT00362752 Phase 2
4 Sorafenib for Hepatopulmonary Syndrome Recruiting NCT02021929 Phase 2
5 Bosentan for Treatment of Hepatopulmonary Syndrome in Patients With Liver Cirrhosis Terminated NCT01518595 Phase 2
6 Pilot Study of Pentoxifylline for Hepatopulmonary Syndrome Terminated NCT00593658 Phase 1
7 Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary Syndrome Unknown status NCT02148536
8 Efficacy of Pentoxifylline and Rifaximin Combination in Pentoxifylline Refractory Clinical and Subclinical Hepatopulmonary Syndrome Unknown status NCT01676597
9 Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study Active, not recruiting NCT03092401

Search NIH Clinical Center for Hepatopulmonary Syndrome

Cochrane evidence based reviews: hepatopulmonary syndrome

Genetic Tests for Hepatopulmonary Syndrome

Anatomical Context for Hepatopulmonary Syndrome

MalaCards organs/tissues related to Hepatopulmonary Syndrome:

39
Liver, Lung, Endothelial, Smooth Muscle, Monocytes, Brain, Bone

Publications for Hepatopulmonary Syndrome

Articles related to Hepatopulmonary Syndrome:

(show top 50) (show all 469)
id Title Authors Year
1
CXCR2 is involved in pulmonary intravascular macrophage accumulation and angiogenesis in a rat model of hepatopulmonary syndrome. ( 27879294 )
2017
2
Live donor liver transplantation for a child presented with severe hepatopulmonary syndrome and nodular liver lesions due to Abernethy malformation. ( 28078819 )
2017
3
Autoimmune hepatitis in a child presenting with hepatopulmonary syndrome (HPS). ( 26992455 )
2016
4
Severe Hepatopulmonary Syndrome in an Adolescent Patient with Non-Cirrhotic Portal Fibrosis. ( 28008407 )
2016
5
Nitric oxide metabolites, nitrative stress, and paraoxonase activity in hepatopulmonary syndrome. ( 26051624 )
2016
6
Frequency of Hepatopulmonary Syndrome (HPS) Among Patients With Liver Cirrhosis: A Letter to Editor. ( 27148388 )
2016
7
Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension. ( 26870333 )
2016
8
Serum bile acids in patients with hepatopulmonary syndrome. ( 27951601 )
2016
9
Response to Sildenafil in a Patient With Coexisting Post-Liver Transplant Portopulmonary Hypertension and Hepatopulmonary Syndrome. ( 27001306 )
2016
10
CHARACTER AND FREQUENCY OF THE VARIATIONS OF CO- AND POLYMORBID SYNTROPIC EXTRAHEPATIC LESIONS AND THEIR DEPENDENCE ON THE HEPATOPULMONARY SYNDROME SEVERITY DEGREE IN CIRRHOTIC PATIENTS. ( 28009313 )
2016
11
The role of splenic reservoir monocytes in pulmonary vascular monocyte accumulation in experimental hepatopulmonary syndrome. ( 27029414 )
2016
12
A Case of Hepatopulmonary Syndrome. ( 27134920 )
2016
13
Paediatric intrapulmonary right-to-left shunt caused by hepatopulmonary syndrome. ( 27165716 )
2016
14
International Liver Transplant Society Practice Guidelines: Diagnosis and Management of Hepatopulmonary Syndrome and Portopulmonary Hypertension. ( 27326810 )
2016
15
CT Scan Does Not Differentiate Patients with Hepatopulmonary Syndrome from Other Patients with Liver Disease. ( 27384058 )
2016
16
Prevalence, Severity, and Prognostic Effect of Hepatopulmonary Syndrome in Liver Transplant Candidates. ( 27020907 )
2016
17
MIR196A2 rs11614913 CA >A T polymorphism correlates with an increased risk of hepatopulmonary syndrome in liver cirrhosis: a case-control study in China. ( 27509319 )
2016
18
A case report of suspected hepatopulmonary syndrome secondary to ductal plate malformation with chronic active hepatitis in a dog. ( 26616155 )
2016
19
Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. ( 27383124 )
2016
20
Inhibition of autophagy ameliorates pulmonary microvascular dilation and PMVECs excessive proliferation in rat experimental hepatopulmonary syndrome. ( 27480323 )
2016
21
Hepatopulmonary Syndrome and Liver Transplantation: A Recent Review of the Literature. ( 27047772 )
2016
22
Hepatopulmonary Syndrome in Patients With Cystic Fibrosis and Liver Disease. ( 26867851 )
2016
23
Hepatopulmonary Syndrome: A Brief Review. ( 27352437 )
2016
24
The Role of TEE in Diagnosing Hepatopulmonary Syndrome and Cryptogenic Cirrhosis. ( 27656299 )
2016
25
Hepatopulmonary syndrome: What we know and what we would like to know. ( 27433086 )
2016
26
Down-regulation of common NFI_B-iNOS pathway by chronic Thalidomide treatment improves Hepatopulmonary Syndrome and Muscle Wasting in rats with Biliary Cirrhosis. ( 28009008 )
2016
27
Rosuvastatin improves hepatopulmonary syndrome through inhibition of inflammatory angiogenesis of lung. ( 25940601 )
2015
28
Prevalence and impact on survival of hepatopulmonary syndrome and cirrhotic cardiomyopathy in a cohort of cirrhotic patients. ( 25974637 )
2015
29
A 45-Year-Old Undiagnosed Cirrhotic Patient with Hepatopulmonary Syndrome as First Presentation: A Case Report. ( 26489790 )
2015
30
Clinical characteristics, predictors, and survival among patients with hepatopulmonary syndrome. ( 25864216 )
2015
31
Accurate measurement of the normality values of macroaggregated albumin lung perfusion scan in hepatopulmonary syndrome. ( 26184840 )
2015
32
Response to 'The role of macroaggregated albumin lung perfusion scan in hepatopulmonary syndrome: are we ready to draw conclusions?' ( 25761922 )
2015
33
The involvement of aquaporin 1 in the hepatopulmonary syndrome rat serum-induced migration of pulmonary arterial smooth muscle cells via the p38-MAPK pathway. ( 26315345 )
2015
34
A case of hepatopulmonary syndrome. ( 26693337 )
2015
35
Congenital extrahepatic portosystemic shunt: an underdiagnosed but treatable cause of hepatopulmonary syndrome. ( 26311567 )
2015
36
MicroRNA-101 inhibits proliferation of pulmonary microvascular endothelial cells in a rat model of hepatopulmonary syndrome by targeting the JAK2/STAT3 signaling pathway. ( 26498873 )
2015
37
Extracorporeal membrane oxygenation after liver transplantation in a patient with hepatopulmonary syndrome and an atrial septal defect. ( 25837880 )
2015
38
Role of Transjugular Intrahepatic Portosystemic Shunts in the Management of Hepatopulmonary Syndrome: A Systemic Literature Review. ( 26074026 )
2015
39
Proposed management algorithm for severe hypoxemia after liver transplantation in the hepatopulmonary syndrome. ( 25649047 )
2015
40
Exercise capacity of cirrhotic patients with hepatopulmonary syndrome. ( 25864217 )
2015
41
Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment. ( 25627425 )
2015
42
Variability of Oxygenation in Possible Hepatopulmonary Syndrome: Effects of Requiring Two Abnormal Arterial Blood Gas Results for Diagnosis. ( 25586084 )
2015
43
The role of macroaggregated albumin lung perfusion scan in hepatopulmonary syndrome: are we ready to draw conclusions? ( 25688443 )
2015
44
Hepatopulmonary Syndrome. ( 25732713 )
2015
45
Liver Transplantation After Bone Marrow Transplantation for End Stage Liver Disease with Severe Hepatopulmonary Syndrome in Dyskeratosis Congenita: A Literature First. ( 26900277 )
2015
46
CT Pulmonary Angiography Features of a Hepatopulmonary Syndrome. ( 26175599 )
2015
47
Brain abscess in hepatopulmonary syndrome associated with biliary atresia. ( 26711920 )
2015
48
Hepatopulmonary Syndrome Is a Frequent Cause of Dyspnea in the Short Telomere Disorders. ( 26158642 )
2015
49
Aggravation of hepatopulmonary syndrome after sildenafil treatment in a patient with coexisting portopulmonary hypertension. ( 25653708 )
2015
50
MicroRNA-199a-5p Regulates the Proliferation of Pulmonary Microvascular Endothelial Cells in Hepatopulmonary Syndrome. ( 26430741 )
2015

Variations for Hepatopulmonary Syndrome

Expression for Hepatopulmonary Syndrome

Search GEO for disease gene expression data for Hepatopulmonary Syndrome.

Pathways for Hepatopulmonary Syndrome

Pathways related to Hepatopulmonary Syndrome according to GeneCards Suite gene sharing:

(show all 41)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 AKT1 EDN1 EDNRA EDNRB NOS2 NOS3
2
Show member pathways
13.22 AKT1 HMOX1 NOS2 TNF VEGFA VWF
3
Show member pathways
13.18 AKT1 ALB NOS2 NOS3 VEGFA VWF
4
Show member pathways
12.77 AKT1 EDN1 EDNRB NOS3 TNF
5
Show member pathways
12.65 AKT1 EDN1 EDNRA NOS3 VEGFA
6 12.49 AKT1 NOS3 VEGFA VWF
7 12.49 AKT1 EDNRA EDNRB NOS2 VEGFA
8
Show member pathways
12.48 AKT1 NOS2 NOS3 TNF
9
Show member pathways
12.47 AKT1 NOS3 TNF VEGFA
10
Show member pathways
12.29 AKT1 NOS2 NOS3 VEGFA
11
Show member pathways
12.11 EDNRA EDNRB NOS2 NOS3
12
Show member pathways
12.05 AKT1 EDN1 TNF
13 12.04 AKT1 NOS2 TNF VEGFA
14 11.99 AKT1 NOS2 NOS3
15 11.93 AKT1 NOS3 VWF
16 11.91 AKT1 NOS3 TNF
17
Show member pathways
11.87 AKT1 NOS3 TNF
18 11.86 AKT1 EDN1 TNF
19 11.78 AKT1 HMOX1 NOS2 TNF VEGFA
20
Show member pathways
11.77 AKT1 NOS3 VEGFA
21 11.73 HMOX1 NOS3 VWF
22 11.65 AKT1 EDN1 NOS3 TNF VEGFA
23 11.59 AKT1 NOS2 NOS3
24 11.58 AKT1 EDN1 HMOX1 NOS3 TNF VEGFA
25 11.56 EDN1 HMOX1 TNF
26
Show member pathways
11.55 NOS2 TNF VEGFA
27 11.47 EDN1 NOS3 VEGFA
28 11.43 AKT1 NOS2 VEGFA
29 11.43 AKT1 EDN1 EDNRA EDNRB
30 11.37 AKT1 EDN1 HMOX1 NOS2 VEGFA
31 11.22 EDN1 NOS2 VEGFA
32 11.2 EDN1 EDNRA EDNRB NOS3
33 11.11 EDN1 EDNRA EDNRB
34
Show member pathways
11.1 EDN1 EDNRA
35 11.1 AKT1 NOS3
36 11.1 AKT1 EDN1 HMOX1 NOS2 NOS3 VEGFA
37 11.06 NOS2 NOS3
38 10.99 AKT1 NOS3 VEGFA
39 10.95 HMOX1 TNF
40 10.76 NOS2 NOS3
41 10.51 NOS2 NOS3

GO Terms for Hepatopulmonary Syndrome

Cellular components related to Hepatopulmonary Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 9.13 ALB VEGFA VWF
2 Weibel-Palade body GO:0033093 8.62 EDN1 VWF

Biological processes related to Hepatopulmonary Syndrome according to GeneCards Suite gene sharing:

(show all 47)
id Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.87 EDN1 EDNRA NOS3 VEGFA
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.86 EDN1 EDNRA EDNRB
3 platelet degranulation GO:0002576 9.85 ALB VEGFA VWF
4 cellular response to lipopolysaccharide GO:0071222 9.85 EDNRB NOS2 TNF
5 negative regulation of gene expression GO:0010629 9.85 AKT1 NOS2 NR0B2 TNF
6 positive regulation of angiogenesis GO:0045766 9.84 HMOX1 NOS3 VEGFA
7 positive regulation of protein phosphorylation GO:0001934 9.83 AKT1 EDNRB TNF VEGFA
8 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.82 AKT1 EDN1 TNF
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 AKT1 TNF VEGFA
10 positive regulation of MAP kinase activity GO:0043406 9.75 EDN1 TNF VEGFA
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 AKT1 EDN1 TNF
12 regulation of nitric-oxide synthase activity GO:0050999 9.7 AKT1 NOS3
13 positive regulation of protein complex assembly GO:0031334 9.7 TNF VEGFA
14 vasodilation GO:0042311 9.7 EDNRB NOS3
15 neural crest cell development GO:0014032 9.69 EDN1 EDNRA
16 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.69 AKT1 VEGFA
17 positive regulation of blood vessel endothelial cell migration GO:0043536 9.69 AKT1 VEGFA
18 glucose transport GO:0015758 9.69 AKT1 EDN1 EDNRA
19 regulation of pH GO:0006885 9.68 EDN1 EDNRB
20 nitric oxide mediated signal transduction GO:0007263 9.68 NOS2 NOS3
21 regulation of blood vessel size GO:0050880 9.68 EDN1 NOS3
22 negative regulation of cAMP biosynthetic process GO:0030818 9.67 EDN1 EDNRA
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 AKT1 NOS3 TNF
24 cellular response to hypoxia GO:0071456 9.67 AKT1 EDN1 HMOX1 VEGFA
25 positive regulation of urine volume GO:0035810 9.66 EDN1 EDNRB
26 positive regulation of renal sodium excretion GO:0035815 9.65 EDN1 EDNRB
27 negative regulation of macroautophagy GO:0016242 9.65 AKT1 HMOX1
28 enteric nervous system development GO:0048484 9.64 EDNRA EDNRB
29 positive regulation of guanylate cyclase activity GO:0031284 9.63 NOS2 NOS3
30 positive regulation of chemokine biosynthetic process GO:0045080 9.63 HMOX1 TNF
31 artery smooth muscle contraction GO:0014824 9.62 EDN1 EDNRA
32 response to fluid shear stress GO:0034405 9.62 AKT1 NOS3
33 arginine catabolic process GO:0006527 9.61 NOS2 NOS3
34 branching involved in blood vessel morphogenesis GO:0001569 9.61 EDN1 EDNRA VEGFA
35 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.6 EDN1 NOS3
36 epithelial fluid transport GO:0042045 9.59 EDN1 EDNRB
37 negative regulation of cellular protein metabolic process GO:0032269 9.58 EDN1 EDNRB
38 positive regulation of vasodilation GO:0045909 9.58 HMOX1 NOS2 NOS3
39 vein smooth muscle contraction GO:0014826 9.56 EDN1 EDNRB
40 vasoconstriction GO:0042310 9.5 EDN1 EDNRA EDNRB
41 endothelin receptor signaling pathway GO:0086100 9.48 EDNRA EDNRB
42 smooth muscle hyperplasia GO:0014806 9.46 HMOX1 NOS3
43 positive regulation of smooth muscle cell proliferation GO:0048661 9.46 AKT1 EDN1 HMOX1 TNF
44 nitric oxide biosynthetic process GO:0006809 9.43 AKT1 NOS2 NOS3
45 response to hypoxia GO:0001666 9.35 EDN1 EDNRA HMOX1 NOS2 VEGFA
46 regulation of blood pressure GO:0008217 9.02 EDN1 EDNRA EDNRB HMOX1 NOS3
47 negative regulation of transcription from RNA polymerase II promoter GO:0000122 10.04 EDN1 EDNRB NR0B2 TNF VEGFA

Molecular functions related to Hepatopulmonary Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.83 AKT1 ALB TNF VEGFA VWF
2 protein homodimerization activity GO:0042803 9.8 HMOX1 NOS2 NR0B2 VEGFA VWF
3 heme binding GO:0020037 9.65 HMOX1 NOS2 NOS3
4 FMN binding GO:0010181 9.46 NOS2 NOS3
5 arginine binding GO:0034618 9.32 NOS2 NOS3
6 NADPH-hemoprotein reductase activity GO:0003958 9.26 NOS2 NOS3
7 tetrahydrobiopterin binding GO:0034617 9.16 NOS2 NOS3
8 nitric-oxide synthase activity GO:0004517 8.96 NOS2 NOS3
9 endothelin receptor activity GO:0004962 8.62 EDNRA EDNRB
10 protein binding GO:0005515 10.15 AKT1 ALB EDN1 EDNRA EDNRB HMOX1

Sources for Hepatopulmonary Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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