MCID: HPT014
MIFTS: 56

Hepatorenal Syndrome malady

Rare diseases, Gastrointestinal diseases, Nephrological diseases, Liver diseases categories

Summaries for Hepatorenal Syndrome

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66Wikipedia, 34MalaCards
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Wikipedia:66 Hepatorenal syndrome (often abbreviated HRS) is a life-threatening medical condition that consists of... more...

MalaCards: Hepatorenal Syndrome is related to alcoholic hepatitis and liver cirrhosis. An important gene associated with Hepatorenal Syndrome is ALB (albumin), and among its related pathways are Development Angiotensin activation of ERK and Gastrin-CREB signalling pathway via PKC and MAPK. The compounds toki-shakuyaku-san and 51-cr-edta have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and skin, and related mouse phenotypes are adipose tissue and muscle.

Aliases & Classifications for Hepatorenal Syndrome

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9Disease Ontology, 44NIH Rare Diseases, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 26ICD10
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Classifications:



Aliases & Descriptions:

hepatorenal syndrome 9 44 46 63


External Ids:

Disease Ontology9 DOID:11823
MeSH36 D006530
SNOMED-CT59 51292008
ICD9CM28 572.4
ICD1026 K76.7

Related Diseases for Hepatorenal Syndrome

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18GeneCards, 19GeneDecks
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Diseases related to Hepatorenal Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1alcoholic hepatitis30.7F2, TNF
2liver cirrhosis30.5CST3, REN, AQP2, EDN3, EDN1, F2
3peritonitis30.5F2, TNF, AQP1, ALB
4alcoholic liver cirrhosis30.4ALB, F2
5hepatopulmonary syndrome30.2EDN1, ALB
6acute liver failure30.2F2, ALB
7hypertension30.2F2, EDN1, NPY, NPPA, ALB, CST3
8portal hypertension30.2F2, EDN1, ALB
9hepatitis b30.1ALB, F2
10glomerulonephritis30.1ALB, NAGLU, EDN3
11hepatitis c30.1ALB, IL18, F2
12sepsis30.0F2, TNF, IL18, CST3, ALB
13pre-eclampsia29.8F2, EDN1, AQP2, NAGLU, REN, IL18
14hepatitis10.7
15liver disease10.5
16obstructive jaundice10.2
17pancreatitis10.2
18blindness10.2
19hypoaldosteronism10.1REN
20congestive heart failure10.1REN
21fibromuscular dysplasia10.1REN
22mitral valve disease10.1NPPA
23sick sinus syndrome10.1NPPA
24dysfibrinogenemia10.1F2
25hypersplenism10.1F2
26diabetes insipidus10.1AQP2
27polyhydramnios10.1AQP1
28vascular disease10.1TNF
29varicose veins10.1F2, ALB
30esophageal varix10.1ALB, F2
31cor pulmonale10.1EDN1, NPPA
32ovarian hyperstimulation syndrome10.1REN, ALB
33inappropriate adh syndrome10.1NPPA, AQP2
34low renin hypertension10.1REN, EDN1
35syndrome of inappropriate antidiuretic hormone10.1AQP2, NPPA
36acute pyelonephritis10.1NAGLU
37conn's syndrome10.1REN, NPPA
38hydronephrosis10.1NAGLU
39chronic pyelonephritis10.1NAGLU
40primary pulmonary hypertension10.1EDN1, NPPA
41brain edema10.1ALB, AQP1
42hepatic encephalopathy10.1F2, ALB
43pyelonephritis10.1NAGLU
44nephrogenic diabetes insipidus10.1AQP2, AQP1
45pulmonary embolism10.1ALB, F2
46intestinal obstruction10.1EDN3, ALB
47bilirubin metabolic disorder10.1F2, ALB
48metabolic acidosis10.1AQP2, REN, ALB
49anuria10.1ACE
50acute kidney tubular necrosis10.1NAGLU, NPPA

Graphical network of the top 20 diseases related to Hepatorenal Syndrome:



Diseases related to hepatorenal syndrome

Symptoms for Hepatorenal Syndrome

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Drugs & Therapeutics for Hepatorenal Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hepatorenal Syndrome

Drug clinical trials:

Search ClinicalTrials for Hepatorenal Syndrome

Search NIH Clinical Center for Hepatorenal Syndrome

Search CenterWatch for Hepatorenal Syndrome

Genetic Tests for Hepatorenal Syndrome

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Anatomical Context for Hepatorenal Syndrome

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34MalaCards
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MalaCards organs/tissues related to Hepatorenal Syndrome:

34
Liver, Kidney, Skin, Bone, Heart, Breast

Animal Models for Hepatorenal Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hepatorenal Syndrome:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.2NPY, IL18, ACE, TNF
2MP:00053698.2EDN1, TNF, REN, IL18, CST3, ALB
3MP:00053817.9F2, EDN1, EDN3, TNF, IL18, ALB
4MP:00107717.9F2, EDN3, TNF, AQP2, NAGLU, IL18
5MP:00053897.8F2, TNF, AQP2, AQP1, REN, ACE
6MP:00053707.4TNF, NAGLU, ACE, ALB, NPY
7MP:00053677.1NPY, EDN1, AQP2, AQP1, NAGLU, REN
8MP:00053976.7F2, TNF, AQP2, AQP1, NAGLU, REN
9MP:00036316.6TNF, EDN3, EDN1, F2, AQP1, NAGLU
10MP:00053856.4F2, EDN1, TNF, AQP1, NAGLU, REN
11MP:00053866.4EDN3, TNF, AQP2, AQP1, NAGLU, REN
12MP:00053786.4F2, TNF, AQP2, AQP1, NAGLU, REN
13MP:00107686.2TNF, EDN3, EDN1, F2, AQP2, AQP1
14MP:00053766.0AQP1, AQP2, TNF, EDN1, F2, REN

Publications for Hepatorenal Syndrome

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53PubMed
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Articles related to Hepatorenal Syndrome:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Results of pretransplant treatment of hepatorenal syndrome with terlipressin. (23652609)
2013
2
Native renal function after combined liver-kidney transplant for type 1 hepatorenal syndrome: initial report on the use of postoperative Technetium-99 m-mercaptoacetyltriglycine scans. (23384317)
2013
3
Renal and circulatory effects of large volume plasma expansion in patients with hepatorenal syndrome type 1. (22345341)
2012
4
On the role of pentoxifylline versus other TNF-alpha inhibitors in the prevention of hepatorenal syndrome. (22595802)
2012
5
Severe acute alcoholic hepatitis and hepatorenal syndrome: role of transjugular intrahepatic portosystemic stent shunt. (22802893)
2012
6
Living donor liver transplantation for hepatorenal syndrome: to do or not to do? That is the question. (22740330)
2012
7
Clinical outcomes of patients with hepatorenal syndrome after living donor liver transplantation. (22714872)
2012
8
Terlipressin in hepatorenal syndrome: a systematic review and meta-analysis. (20306131)
2011
9
Renal failure in patients with cirrhosis: hepatorenal syndrome and renal support strategies. (20124895)
2010
10
Terlipressin therapy for reversal of type 1 hepatorenal syndrome: a meta-analysis of randomized controlled trials. (20074149)
2010
11
Hepatorenal syndrome: a review. (21410072)
2010
12
Systematic review of randomized trials on vasoconstrictor drugs for hepatorenal syndrome. (19885875)
2010
13
TIPS for the treatment of refractory ascites, hepatorenal syndrome and hepatic hydrothorax: a critical update. (20581246)
2010
14
Acute kidney injury: new concepts. Hepatorenal syndrome: the role of vasopressors. (18802378)
2008
15
Long-term outcome of patients treated with terlipressin for types 1 and 2 hepatorenal syndrome. (17784863)
2008
16
Towards goal-directed therapy of hepatorenal syndrome: we have the tools but we need the trials. (18394181)
2008
17
Management of hepatorenal syndrome. (18539334)
2008
18
Hepatorenal syndrome: an update. (17505686)
2007
19
Hepatorenal syndrome. What's new in 2007?]. (17345016)
2007
20
Possible increased risk of pulmonary edema in patients with hepatorenal syndrome on adding octreotide to albumin / noradrenaline therapies. (17496406)
2007
21
Terlipressin for hepatorenal syndrome. (17054242)
2006
22
Generalized decreased osseous uptake on bone scintigraphy in hepatorenal syndrome. (16319651)
2005
23
Hepatorenal syndrome: a dreaded complication of end-stage liver disease. (15667508)
2005
24
Vasopressin, not octreotide, may be beneficial in the treatment of hepatorenal syndrome: a retrospective study. (15956066)
2005
25
Advances in therapy for ascites and hepatorenal syndrome]. (15650969)
2005
26
Hepatorenal syndrome. (15381144)
2005
27
Correlative study between angiotensin-converting enzyme gene polymorphism and hepatorenal syndrome]. (15698501)
2005
28
Anti-leukotriene drugs in the prevention and treatment of hepatorenal syndrome. (12628221)
2003
29
Type-2 hepatorenal syndrome and refractory ascites: role of transjugular intrahepatic portosystemic stent-shunt in eighteen patients with advanced cirrhosis awaiting orthotopic liver transplantation. (14696397)
2003
30
Terlipressin-induced vasoconstriction reversed with N-acetylcysteine: a case for combined use in hepatorenal syndrome? (12454887)
2002
31
Current management and novel therapeutic strategies for refractory ascites and hepatorenal syndrome. (11391027)
2001
32
Successful therapy of hepatorenal syndrome with norepinephrine]. (11194884)
2000
33
Reversibility of hepatorenal syndrome in an anuric patient with child C cirrhosis requiring haemodialysis for 7 weeks. (10862650)
2000
34
More therapy for hepatorenal syndrome. (10220524)
1999
35
Pathophysiology, clinical features and management of hepatorenal syndrome. (10710816)
1998
36
Fetal enterolithiasis and anhydramnios; due to in utero hepatorenal syndrome? (9854732)
1998
37
Pathophysiology and treatment of hepatorenal syndrome. (9660529)
1998
38
Treatment with terlipressin as a bridge to liver transplantation in a patient with hepatorenal syndrome. (9658623)
1998
39
Hepatorenal syndrome. (18417943)
1996
40
Hepatorenal syndrome. Long-term treatment with terlipressin as a bridge to liver transplantation. (8654133)
1996
41
Tc-99m DTPA and I-131 hippurate renography. Findings in hepatorenal syndrome. (1617840)
1992
42
Urinary sodium levels related to jaundice duration in the assessment of postoperative risk of hepatorenal syndrome in elderly patients undergoing surgery for biliary obstruction. (2745041)
1989
43
Effects of lumbar sympathetic block on kidney function in cirrhotic patients with hepatorenal syndrome. (3693861)
1987
44
Pathogenesis of the hepatorenal syndrome. (2953301)
1987
45
Spontaneous ascites filtration and reinfusion (SAFR) as ambulatory chronic treatment for hepatorenal syndrome. (3837486)
1985
46
Peritonitis in a patient with hepatorenal syndrome. (6731713)
1984
47
Therapeutic trial of thromboxane synthesis inhibition in the hepatorenal syndrome. (6593268)
1984
48
Hepatorenal syndrome. (7002455)
1980
49
Effects of a portacaval or peritoneovenous shunt on renin in the hepatorenal syndrome. (491398)
1979
50
CURRENT CONCEPT OF THE HEPATORENAL SYNDROME. A CLINICO-PATHOLOGIC STUDY. (14077871)
1963

Variations for Hepatorenal Syndrome

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Expression for genes affiliated with Hepatorenal Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatorenal Syndrome

Search GEO for disease gene expression data for Hepatorenal Syndrome.

Pathways for genes affiliated with Hepatorenal Syndrome

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Sources:
51PathCards, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 52PharmGKB, 31KEGG, 55R&D Systems
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Pathways related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.5F2, EDN1, EDN3
2
Show member pathways
9.5EDN3, EDN1, F2
39.5IL18, TNF
49.5IL18, TNF
5
Show member pathways
thioredoxin pathway39
9.4ALB, TNF, F2
69.4EDN1, TNF, NPPA
7
Show member pathways
9.4ACE, REN
89.2CST3, ACE
9
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.2EDN1, TNF, IL18
10
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.2IL18, TNF, F2
11
Show member pathways
9.0NPY, EDN3, EDN1, F2
12
Show member pathways
8.7TNF, CST3, NPPA, NPY

Compounds for genes affiliated with Hepatorenal Syndrome

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 230)
idCompoundScoreTop Affiliating Genes
1toki-shakuyaku-san469.9REN, NPPA, EDN1
251-cr-edta469.7CST3, NPPA, ALB, REN
3ibopamine469.3REN, ACE, NPPA
4cilazapril46 1210.2EDN1, REN, ACE, NPPA
5fosinopril46 1210.2ACE, NPPA, ALB, REN
6trandolapril46 1210.2ACE, NPPA, REN, EDN1
7omapatrilat469.2EDN1, REN, NPPA, ACE
8alacepril469.2REN, ACE, NPPA
9quinapril46 52 1211.2EDN1, ACE, REN, NPPA
10enalaprilat469.2REN, EDN1, ACE, NPPA
11valsartan46 62 30 1212.1EDN1, REN, ACE, ALB
12irbesartan46 30 52 1212.1ALB, REN, ACE, EDN1
13inulin469.1CST3, REN, NAGLU, ALB, NPPA
14desmopressin46 62 30 1212.1NPPA, F2, AQP2, NAGLU, REN
15thiorphan46 30 1211.0EDN3, EDN1, NPPA, ACE
16diltiazem46 30 52 1212.0REN, EDN1, F2, ACE
17ramipril46 129.9ALB, REN, NPPA, CST3, ACE
18hydrochlorothiazide46 30 52 25 1212.8ACE, REN, AQP2, ALB
19sodium nitroprusside468.8EDN1, EDN3, AQP1, REN, NPPA, NPY
20lisinopril46 52 25 1211.8ACE, ALB, REN, NPPA, NPY
21amlodipine46 52 25 1211.8ALB, ACE, REN, NPPA
22digoxin46 62 52 25 1212.8F2, NPPA, CST3, REN, ACE
23perindopril46 52 1210.7NAGLU, REN, ACE, NPPA, ALB
24phosphoramidon46 129.6NPPA, NPY, EDN3, EDN1, ACE
25kininogen468.6NPPA, ALB, CST3, REN, ACE, F2
26spironolactone46 62 30 52 1212.6REN, ALB, NPPA, ACE
27homocysteine46 259.6ALB, CST3, IL18, NAGLU, F2
28epinephrine46 25 1210.5F2, REN, NPPA, IL18, NPY, AQP2
29enalapril46 52 1210.4REN, NPPA, ALB, ACE, NAGLU, EDN1
30losartan46 52 30 1211.4EDN1, NAGLU, NPPA, ALB, ACE, REN
31furosemide46 62 30 52 25 1213.4ALB, ACE, NPPA, AQP2, NAGLU, REN
32pge2468.3TNF, EDN1, EDN3, AQP2, REN, IL18
33captopril46 62 52 30 1212.3EDN1, EDN3, REN, ACE, ALB, NPPA
34indomethacin46 30 62 1211.2NPY, TNF, IL18, REN, EDN3, EDN1
35methotrexate52 46 1210.2F2, TNF, NAGLU, IL18, CST3, ALB
36histamine46 30 2510.1EDN1, ALB, EDN3, TNF, NPY, IL18
37vegf467.9NPPA, CST3, TNF, IL18, EDN1, AQP1
38prostacyclin467.8NPY, NPPA, REN, TNF, EDN3, EDN1
39norepinephrine46 25 129.8REN, EDN1, NPY, ACE, IL18, EDN3
40nifedipine46 30 52 1210.8NPY, ACE, EDN3, REN, NAGLU, EDN1
41cyclosporin a46 30 629.7CST3, EDN1, NPPA, F2, TNF, AQP2
42lactate467.7F2, NPY, CST3, ALB, IL18, NAGLU
43arginine467.6NPY, AQP1, REN, AQP2, EDN3, IL18
44alanine467.3CST3, ALB, NPY, IL18, NAGLU, AQP1
45potassium46 25 129.2NPPA, CST3, ACE, REN, NAGLU, AQP1
46sodium46 257.9IL18, ACE, REN, NAGLU, AQP1, AQP2
47glucose466.5NPY, EDN3, IL18, CST3, AQP1, NAGLU
48nitric oxide46 25 128.1TNF, EDN3, EDN1, AQP2, AQP1, NAGLU
49creatinine466.1NPY, NPPA, ALB, CST3, IL18, ACE
50calcium46 52 25 129.0IL18, ALB, NPPA, EDN3, NPY, CST3

GO Terms for genes affiliated with Hepatorenal Syndrome

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17Gene Ontology
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Cellular components related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700627.7AQP1, NAGLU, ACE, CST3, ALB, AQP2
2extracellular spaceGO:0056155.9NPY, F2, EDN1, EDN3, TNF, REN
3extracellular regionGO:0055765.7TNF, EDN3, EDN1, F2, REN, ACE

Biological processes related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1nitric oxide transportGO:03018510.2EDN1, AQP1
2vein smooth muscle contractionGO:01482610.2EDN3, EDN1
3renal water transportGO:00309710.2AQP1, AQP2
4peptide hormone secretionGO:03007210.2EDN3, EDN1
5cellular response to mercury ionGO:07128810.2AQP2, AQP1
6regulation of systemic arterial blood pressure by endothelinGO:00310010.2EDN1, EDN3
7artery smooth muscle contractionGO:01482410.1EDN3, EDN1
8cellular response to copper ionGO:07128010.1AQP2, AQP1
9glycerol transportGO:01579310.1AQP2, AQP1
10inositol phosphate-mediated signalingGO:04801610.1EDN3, EDN1
11cGMP biosynthetic processGO:00618210.1AQP1, NPPA
12positive regulation of hormone secretionGO:04688710.1EDN3, EDN1
13cell volume homeostasisGO:00688410.1AQP2, AQP1
14positive regulation of heart rateGO:01046010.1EDN3, EDN1
15vasoconstrictionGO:04231010.0EDN3, EDN1
16response to lipopolysaccharideGO:0324969.9EDN1, AQP2, REN
17response to salt stressGO:0096519.8AQP2, TNF
18positive regulation of mitosisGO:0458409.7EDN1, EDN3, TNF
19positive regulation of nitric oxide biosynthetic processGO:0454299.7TNF, EDN1
20positive regulation of MAP kinase activityGO:0434069.7TNF, EDN3, EDN1
21angiotensin maturationGO:0020039.7ACE, REN
22cell surface receptor signaling pathwayGO:0071669.6EDN3, EDN1, F2
23middle ear morphogenesisGO:0424749.6EDN1, NAGLU
24positive regulation of NF-kappaB import into nucleusGO:0423469.6IL18, TNF
25response to hypoxiaGO:0016669.6EDN1, TNF, NPPA
26lipopolysaccharide-mediated signaling pathwayGO:0316639.4IL18, TNF
27regulation of vasoconstrictionGO:0192299.4ACE, EDN3, EDN1
28positive regulation of JUN kinase activityGO:0435079.4TNF, EDN1
29regulation of blood pressureGO:0082179.0NPY, NPPA, ACE, REN

Molecular functions related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycerol transmembrane transporter activityGO:0151689.8AQP1, AQP2
2water transmembrane transporter activityGO:0053729.7AQP2, AQP1
3hormone activityGO:0051799.3NPPA, EDN3, EDN1
4cytokine activityGO:0051259.2IL18, TNF, EDN1
5receptor bindingGO:0051028.8NPY, NPPA, REN, EDN3, F2

Products for genes affiliated with Hepatorenal Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatorenal Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet