MCID: HPT014
MIFTS: 48

Hepatorenal Syndrome malady

Rare diseases, Gastrointestinal diseases, Liver diseases categories

Summaries for Hepatorenal Syndrome

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Wikipedia:63 Hepatorenal syndrome (often abbreviated HRS) is a life-threatening medical condition that consists of... more...

MalaCards based summary: Hepatorenal Syndrome is related to liver disease and alcoholic hepatitis. An important gene associated with Hepatorenal Syndrome is ALB (albumin), and among its related pathways are Development Angiotensin activation of ERK and Gastrin-CREB signalling pathway via PKC and MAPK. The compounds toki-shakuyaku-san and 51-cr-edta have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone, and related mouse phenotypes are adipose tissue and muscle.

Aliases & Classifications for Hepatorenal Syndrome

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Hepatorenal Syndrome, Aliases & Descriptions:

Name: Hepatorenal Syndrome 9 41 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Liver diseases


External Ids:

Disease Ontology9 DOID:11823
MeSH33 D006530
SNOMED-CT55 51292008
ICD9CM27 572.4
ICD1025 K76.7

Related Diseases for Hepatorenal Syndrome

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Diseases related to Hepatorenal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1liver disease31.1F2, TNF, ALB
2alcoholic hepatitis31.1F2, TNF
3alcoholic liver cirrhosis30.9ALB, F2
4peritonitis30.7F2, TNF, AQP1, ALB
5hepatopulmonary syndrome30.7EDN1, ALB
6acute liver failure30.7F2, ALB
7pulmonary hypertension30.6EDN1, NPPA
8portal hypertension30.6F2, EDN1, ALB
9hepatitis b30.5ALB, F2
10glomerulonephritis30.2ALB, NAGLU, EDN3
11hepatitis c30.2ALB, IL18, F2
12liver cirrhosis29.9CST3, REN, AQP2, EDN3, EDN1, F2
13hepatitis10.7
14hypoaldosteronism10.6REN
15congestive heart failure10.6REN
16fibromuscular dysplasia10.5REN
17mitral valve disease10.5NPPA
18sick sinus syndrome10.5NPPA
19dysfibrinogenemia10.5F2
20hypersplenism10.5F2
21diabetes insipidus10.5AQP2
22polyhydramnios10.5AQP1
23vascular disease10.4TNF
24varicose veins10.4F2, ALB
25esophageal varix10.4ALB, F2
26cor pulmonale10.4EDN1, NPPA
27ovarian hyperstimulation syndrome10.4REN, ALB
28inappropriate adh syndrome10.4NPPA, AQP2
29syndrome of inappropriate antidiuretic hormone10.4AQP2, NPPA
30conn's syndrome10.4REN, NPPA
31acute pyelonephritis10.4NAGLU
32hydronephrosis10.4NAGLU
33chronic pyelonephritis10.4NAGLU
34brain edema10.4ALB, AQP1
35hepatic encephalopathy10.4F2, ALB
36pyelonephritis10.4NAGLU
37diabetes insipidus, nephrogenic10.4AQP2, AQP1
38pulmonary embolism10.3ALB, F2
39intestinal obstruction10.3EDN3, ALB
40bilirubin metabolic disorder10.3F2, ALB
41metabolic acidosis10.3AQP2, REN, ALB
42anuria10.3ACE
43acute kidney tubular necrosis10.3NAGLU, NPPA
44diabetic angiopathy10.3EDN1, NAGLU
45hyperhomocysteinemia10.3F2, CST3, ALB
46lipoid nephrosis10.2NAGLU, ALB
47ewing sarcoma10.2EDN1, NPY
48galactosemia10.2ALB, IL18, F2
49autonomic neuropathy10.2REN, ALB, NPY
50renal artery disease10.2ACE, ALB

Graphical network of the top 20 diseases related to Hepatorenal Syndrome:



Diseases related to hepatorenal syndrome

Symptoms for Hepatorenal Syndrome

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Drugs & Therapeutics for Hepatorenal Syndrome

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Drug clinical trials:

Search ClinicalTrials for Hepatorenal Syndrome

Search NIH Clinical Center for Hepatorenal Syndrome

Genetic Tests for Hepatorenal Syndrome

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Anatomical Context for Hepatorenal Syndrome

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MalaCards organs/tissues related to Hepatorenal Syndrome:

31
Liver, Kidney, Bone, Heart, Breast, Skin, Neutrophil

Animal Models for Hepatorenal Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Hepatorenal Syndrome:

35 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.2TNF, ACE, NPY, IL18
2MP:00053698.2ALB, NPPA, IL18, CST3, REN, TNF
3MP:00053817.9TNF, NPY, ALB, EDN3, EDN1, F2
4MP:00107717.9NAGLU, EDN3, TNF, AQP2, IL18, F2
5MP:00053897.8AQP2, AQP1, TNF, F2, ACE, REN
6MP:00053707.4ALB, ACE, NPY, NAGLU, TNF
7MP:00053677.1NPY, NPPA, EDN1, AQP2, AQP1, NAGLU
8MP:00053976.7NPPA, TNF, IL18, AQP2, F2, NAGLU
9MP:00036316.6TNF, AQP1, EDN3, NPY, EDN1, NAGLU
10MP:00053856.4F2, EDN1, TNF, AQP1, NAGLU, REN
11MP:00053866.4ACE, NAGLU, AQP1, AQP2, TNF, EDN3
12MP:00053786.4NPY, ACE, NAGLU, AQP1, TNF, F2
13MP:00107686.2ACE, ALB, AQP2, AQP1, EDN1, F2
14MP:00053766.0REN, CST3, ALB, NPPA, NPY, IL18

Publications for Hepatorenal Syndrome

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Articles related to Hepatorenal Syndrome:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Nonselective I^ blockers increase risk for hepatorenal syndrome and death in patients with cirrhosis and spontaneous bacterial peritonitis. (24631577)
2014
2
Hepatorenal syndrome type 1 and bacterial infection: a catastrophic association in patients with cirrhosis. (24425447)
2014
3
Results of pretransplant treatment of hepatorenal syndrome with terlipressin. (23652609)
2013
4
Severe ischemic bowel necrosis caused by terlipressin during treatment of hepatorenal syndrome. (24459647)
2013
5
Native renal function after combined liver-kidney transplant for type 1 hepatorenal syndrome: initial report on the use of postoperative Technetium-99 m-mercaptoacetyltriglycine scans. (23384317)
2013
6
Renal and circulatory effects of large volume plasma expansion in patients with hepatorenal syndrome type 1. (22345341)
2012
7
On the role of pentoxifylline versus other TNF-alpha inhibitors in the prevention of hepatorenal syndrome. (22595802)
2012
8
Severe acute alcoholic hepatitis and hepatorenal syndrome: role of transjugular intrahepatic portosystemic stent shunt. (22802893)
2012
9
Living donor liver transplantation for hepatorenal syndrome: to do or not to do? That is the question. (22740330)
2012
10
Clinical outcomes of patients with hepatorenal syndrome after living donor liver transplantation. (22714872)
2012
11
Terlipressin in hepatorenal syndrome: a systematic review and meta-analysis. (20306131)
2011
12
Renal failure in patients with cirrhosis: hepatorenal syndrome and renal support strategies. (20124895)
2010
13
Terlipressin therapy for reversal of type 1 hepatorenal syndrome: a meta-analysis of randomized controlled trials. (20074149)
2010
14
Hepatorenal syndrome: a review. (21410072)
2010
15
Systematic review of randomized trials on vasoconstrictor drugs for hepatorenal syndrome. (19885875)
2010
16
TIPS for the treatment of refractory ascites, hepatorenal syndrome and hepatic hydrothorax: a critical update. (20581246)
2010
17
Acute kidney injury: new concepts. Hepatorenal syndrome: the role of vasopressors. (18802378)
2008
18
Long-term outcome of patients treated with terlipressin for types 1 and 2 hepatorenal syndrome. (17784863)
2008
19
Towards goal-directed therapy of hepatorenal syndrome: we have the tools but we need the trials. (18394181)
2008
20
Management of hepatorenal syndrome. (18539334)
2008
21
Hepatorenal syndrome: an update. (17505686)
2007
22
Hepatorenal syndrome. What's new in 2007?]. (17345016)
2007
23
Possible increased risk of pulmonary edema in patients with hepatorenal syndrome on adding octreotide to albumin / noradrenaline therapies. (17496406)
2007
24
Terlipressin for hepatorenal syndrome. (17054242)
2006
25
Generalized decreased osseous uptake on bone scintigraphy in hepatorenal syndrome. (16319651)
2005
26
Hepatorenal syndrome: a dreaded complication of end-stage liver disease. (15667508)
2005
27
Vasopressin, not octreotide, may be beneficial in the treatment of hepatorenal syndrome: a retrospective study. (15956066)
2005
28
Advances in therapy for ascites and hepatorenal syndrome]. (15650969)
2005
29
Hepatorenal syndrome. (15381144)
2005
30
Correlative study between angiotensin-converting enzyme gene polymorphism and hepatorenal syndrome]. (15698501)
2005
31
Anti-leukotriene drugs in the prevention and treatment of hepatorenal syndrome. (12628221)
2003
32
Terlipressin-induced vasoconstriction reversed with N-acetylcysteine: a case for combined use in hepatorenal syndrome? (12454887)
2002
33
Current management and novel therapeutic strategies for refractory ascites and hepatorenal syndrome. (11391027)
2001
34
Successful therapy of hepatorenal syndrome with norepinephrine]. (11194884)
2000
35
Reversibility of hepatorenal syndrome in an anuric patient with child C cirrhosis requiring haemodialysis for 7 weeks. (10862650)
2000
36
More therapy for hepatorenal syndrome. (10220524)
1999
37
Pathophysiology, clinical features and management of hepatorenal syndrome. (10710816)
1998
38
Fetal enterolithiasis and anhydramnios; due to in utero hepatorenal syndrome? (9854732)
1998
39
Pathophysiology and treatment of hepatorenal syndrome. (9660529)
1998
40
Hepatorenal syndrome. (18417943)
1996
41
Tc-99m DTPA and I-131 hippurate renography. Findings in hepatorenal syndrome. (1617840)
1992
42
Urinary sodium levels related to jaundice duration in the assessment of postoperative risk of hepatorenal syndrome in elderly patients undergoing surgery for biliary obstruction. (2745041)
1989
43
Effects of lumbar sympathetic block on kidney function in cirrhotic patients with hepatorenal syndrome. (3693861)
1987
44
Pathogenesis of the hepatorenal syndrome. (2953301)
1987
45
Spontaneous ascites filtration and reinfusion (SAFR) as ambulatory chronic treatment for hepatorenal syndrome. (3837486)
1985
46
Peritonitis in a patient with hepatorenal syndrome. (6731713)
1984
47
Therapeutic trial of thromboxane synthesis inhibition in the hepatorenal syndrome. (6593268)
1984
48
Hepatorenal syndrome. (7002455)
1980
49
Effects of a portacaval or peritoneovenous shunt on renin in the hepatorenal syndrome. (491398)
1979
50
CURRENT CONCEPT OF THE HEPATORENAL SYNDROME. A CLINICO-PATHOLOGIC STUDY. (14077871)
1963

Variations for Hepatorenal Syndrome

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Expression for genes affiliated with Hepatorenal Syndrome

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Search GEO for disease gene expression data for Hepatorenal Syndrome.

Pathways for genes affiliated with Hepatorenal Syndrome

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Pathways related to Hepatorenal Syndrome according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development EDNRB signaling58
Development ACM2 and ACM4 activation of ERK58
Cell adhesion Integrin inside out signaling58
Development G Proteins mediated regulation MARK ERK signaling58
Signal transduction IP3 signaling58
Development Angiotensin signaling via PYK258
Development EPO induced MAPK pathway58
9.5EDN1, EDN3, F2
2
Show member pathways
9.5EDN3, F2, EDN1
39.5TNF, IL18
49.5TNF, IL18
5
Show member pathways
thioredoxin pathway36
9.4F2, TNF, ALB
69.4NPPA, TNF, EDN1
7
Show member pathways
9.4REN, ACE
89.2CST3, ACE
9
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.2IL18, TNF, EDN1
10
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.2F2, TNF, IL18
11
Show member pathways
9.0EDN1, EDN3, NPY, F2
12
Show member pathways
8.7NPPA, CST3, TNF, NPY

Compounds for genes affiliated with Hepatorenal Syndrome

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Compounds related to Hepatorenal Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 230)
idCompoundScoreTop Affiliating Genes
1toki-shakuyaku-san439.9REN, NPPA, EDN1
251-cr-edta439.7CST3, NPPA, ALB, REN
3ibopamine439.3REN, ACE, NPPA
4cilazapril43 1210.2EDN1, REN, ACE, NPPA
5fosinopril43 1210.2ACE, NPPA, ALB, REN
6trandolapril43 1210.2ACE, NPPA, REN, EDN1
7omapatrilat439.2EDN1, REN, NPPA, ACE
8alacepril439.2REN, ACE, NPPA
9quinapril43 49 1211.2EDN1, ACE, REN, NPPA
10enalaprilat439.2REN, EDN1, ACE, NPPA
11valsartan43 59 28 1212.1EDN1, REN, ACE, ALB
12irbesartan43 28 49 1212.1ALB, REN, ACE, EDN1
13inulin439.1CST3, REN, NAGLU, ALB, NPPA
14desmopressin43 59 28 1212.1NPPA, F2, AQP2, NAGLU, REN
15thiorphan43 28 1211.0EDN3, EDN1, NPPA, ACE
16diltiazem43 28 49 1212.0REN, EDN1, F2, ACE
17ramipril43 129.9ALB, REN, NPPA, CST3, ACE
18hydrochlorothiazide43 28 49 24 1212.8ACE, REN, AQP2, ALB
19sodium nitroprusside438.8EDN1, EDN3, AQP1, REN, NPPA, NPY
20lisinopril43 49 24 1211.8ACE, ALB, REN, NPPA, NPY
21amlodipine43 49 24 1211.8ALB, ACE, REN, NPPA
22digoxin43 59 49 24 1212.8F2, NPPA, CST3, REN, ACE
23perindopril43 49 1210.7NAGLU, REN, ACE, NPPA, ALB
24phosphoramidon43 129.6NPPA, NPY, EDN3, EDN1, ACE
25kininogen438.6NPPA, ALB, CST3, REN, ACE, F2
26spironolactone43 59 28 49 1212.6REN, ALB, NPPA, ACE
27homocysteine43 249.6ALB, CST3, IL18, NAGLU, F2
28epinephrine43 24 1210.5F2, REN, NPPA, IL18, NPY, AQP2
29enalapril43 49 1210.4REN, NPPA, ALB, ACE, NAGLU, EDN1
30losartan43 49 28 1211.4EDN1, NAGLU, NPPA, ALB, ACE, REN
31furosemide43 59 28 49 24 1213.4ALB, ACE, NPPA, AQP2, NAGLU, REN
32pge2438.3TNF, EDN1, EDN3, AQP2, REN, IL18
33captopril43 59 49 28 1212.3EDN1, EDN3, REN, ACE, ALB, NPPA
34indomethacin43 28 59 1211.2NPY, TNF, IL18, REN, EDN3, EDN1
35methotrexate49 43 1210.2F2, TNF, NAGLU, IL18, CST3, ALB
36histamine43 28 2410.1EDN1, ALB, EDN3, TNF, NPY, IL18
37vegf437.9NPPA, CST3, TNF, IL18, EDN1, AQP1
38prostacyclin437.8NPY, NPPA, REN, TNF, EDN3, EDN1
39norepinephrine43 24 129.8REN, EDN1, NPY, ACE, IL18, EDN3
40nifedipine43 28 49 1210.8NPY, ACE, EDN3, REN, NAGLU, EDN1
41cyclosporin a43 28 599.7CST3, EDN1, NPPA, F2, TNF, AQP2
42lactate437.7F2, NPY, CST3, ALB, IL18, NAGLU
43arginine437.6NPY, AQP1, REN, AQP2, EDN3, IL18
44alanine437.3CST3, ALB, NPY, IL18, NAGLU, AQP1
45potassium43 24 129.2NPPA, CST3, ACE, REN, NAGLU, AQP1
46sodium43 247.9IL18, ACE, REN, NAGLU, AQP1, AQP2
47glucose436.5NPY, EDN3, IL18, CST3, AQP1, NAGLU
48nitric oxide43 24 128.1TNF, EDN3, EDN1, AQP2, AQP1, NAGLU
49creatinine436.1NPY, NPPA, ALB, CST3, IL18, ACE
50calcium43 49 24 129.0IL18, ALB, NPPA, EDN3, NPY, CST3

GO Terms for genes affiliated with Hepatorenal Syndrome

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Cellular components related to Hepatorenal Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700627.7AQP1, NAGLU, ACE, CST3, ALB, AQP2
2extracellular spaceGO:00056155.9CST3, NPPA, ALB, IL18, ACE, REN
3extracellular regionGO:00055765.7NPY, F2, NPPA, ALB, CST3, IL18

Biological processes related to Hepatorenal Syndrome according to GeneCards Suite gene sharing:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1nitric oxide transportGO:003018510.2AQP1, EDN1
2vein smooth muscle contractionGO:001482610.2EDN3, EDN1
3renal water transportGO:000309710.2AQP2, AQP1
4peptide hormone secretionGO:003007210.2EDN3, EDN1
5cellular response to mercury ionGO:007128810.2AQP1, AQP2
6regulation of systemic arterial blood pressure by endothelinGO:000310010.2EDN1, EDN3
7artery smooth muscle contractionGO:001482410.1EDN3, EDN1
8cellular response to copper ionGO:007128010.1AQP2, AQP1
9glycerol transportGO:001579310.1AQP2, AQP1
10inositol phosphate-mediated signalingGO:004801610.1EDN3, EDN1
11cGMP biosynthetic processGO:000618210.1NPPA, AQP1
12positive regulation of hormone secretionGO:004688710.1EDN3, EDN1
13cell volume homeostasisGO:000688410.1AQP1, AQP2
14positive regulation of heart rateGO:001046010.1EDN1, EDN3
15vasoconstrictionGO:004231010.0EDN3, EDN1
16response to lipopolysaccharideGO:00324969.9EDN1, AQP2, REN
17response to salt stressGO:00096519.8AQP2, TNF
18positive regulation of mitosisGO:00458409.7EDN1, TNF, EDN3
19positive regulation of nitric oxide biosynthetic processGO:00454299.7EDN1, TNF
20positive regulation of MAP kinase activityGO:00434069.7EDN3, EDN1, TNF
21cell surface receptor signaling pathwayGO:00071669.6F2, EDN1, EDN3
22angiotensin maturationGO:00020039.6REN, ACE
23middle ear morphogenesisGO:00424749.6EDN1, NAGLU
24positive regulation of NF-kappaB import into nucleusGO:00423469.6IL18, TNF
25response to hypoxiaGO:00016669.6EDN1, NPPA, TNF
26lipopolysaccharide-mediated signaling pathwayGO:00316639.4TNF, IL18
27regulation of vasoconstrictionGO:00192299.4EDN1, ACE, EDN3
28positive regulation of JUN kinase activityGO:00435079.4EDN1, TNF
29regulation of blood pressureGO:00082179.0NPY, ACE, NPPA, REN

Molecular functions related to Hepatorenal Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycerol transmembrane transporter activityGO:00151689.8AQP1, AQP2
2water transmembrane transporter activityGO:00053729.7AQP1, AQP2
3hormone activityGO:00051799.3NPPA, EDN3, EDN1
4cytokine activityGO:00051259.2TNF, IL18, EDN1
5receptor bindingGO:00051028.8NPY, NPPA, REN, EDN3, F2

Products for genes affiliated with Hepatorenal Syndrome

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Sources for Hepatorenal Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet