MCID: HPT014
MIFTS: 54

Hepatorenal Syndrome malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Hepatorenal Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hepatorenal syndrome (often abbreviated HRS) is a life-threatening medical condition that consists of... more...

MalaCards: Hepatorenal Syndrome is related to hepatitis and liver cirrhosis. An important gene associated with Hepatorenal Syndrome is ALB (albumin), and among its related pathways are Passive Transport by Aquaporins and MicroRNAs in cardiomyocyte hypertrophy. The compounds norepinephrine and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone, and related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Hepatorenal Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

hepatorenal syndrome 8 42 44 60


External Ids:

Disease Ontology8 DOID:11823
MeSH34 D006530
SNOMED-CT56 51292008
ICD9CM27 572.4
ICD1025 K76.7

Related Diseases for Hepatorenal Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hepatorenal Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.9IL18, F2
2liver cirrhosis30.8CST3, NPY, NPPA, EDN3, EDN1, REN
3alcoholic hepatitis30.6F2, TNF
4hepatitis a30.4F2
5peritonitis30.4AQP1, ALB, F2, TNF
6acute liver failure30.3F2, ALB
7hypertension30.3ALB, ACE, F2, REN, EDN1, NPPA
8pancreatitis30.2ALB
9hepatitis c30.2TNF, IL18, F2
10disseminated intravascular coagulation29.9F2
11hepatopulmonary syndrome29.9EDN1, ALB
12leukemia29.9TNF
13portal hypertension29.9EDN1, F2, ALB
14acute kidney tubular necrosis29.9NAGLU, NPPA
15hepatitis b29.9IL18, F2, ALB
16glomerulonephritis29.9EDN3, NAGLU, ALB
17ischemia29.9CST3, EDN1, NAGLU
18pre-eclampsia29.9CST3, NPPA, EDN1, REN, NAGLU, IL18
19liver disease10.5
20obstructive jaundice10.2
21alcoholic liver cirrhosis10.2
22n syndrome10.2
23good syndrome10.1
24uremia10.0ALB
25neuropathy10.0ALB
26wilms tumor10.0REN
27sickle cell disease10.0EDN1
28diarrhea10.0ALB
29meningitis10.0ALB
30proliferative diabetic retinopathy10.0EDN1
31hypoaldosteronism10.0REN
32lung cancer10.0ALB
33thromboembolism10.0F2
34skin disease10.0ALB
35hyperparathyroidism10.0ALB
36diabetes insipidus10.0AQP2
37short bowel syndrome10.0ALB
38portal vein thrombosis10.0F2
39hypothyroidism10.0CST3
40viral hepatitis10.0F2
41acute pancreatitis10.0IL18
42adenocarcinoma10.0AQP1
43glioblastoma multiforme10.0AQP1
44gingivitis10.0CST3
45mitral valve disease10.0NPPA
46addison's disease10.0REN
47allergic rhinitis10.0IL18
48dementia10.0CST3
49ovarian hyperstimulation syndrome10.0ALB, REN
50anorexia nervosa10.0NPY

Graphical network of the top 20 diseases related to Hepatorenal Syndrome:



Diseases related to hepatorenal syndrome

Clinical Features for Hepatorenal Syndrome

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Drugs & Therapeutics for Hepatorenal Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hepatorenal Syndrome

Drug clinical trials:

Search ClinicalTrials for Hepatorenal Syndrome

Search NIH Clinical Center for Hepatorenal Syndrome

Search CenterWatch for Hepatorenal Syndrome

Genetic Tests for Hepatorenal Syndrome

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Anatomical Context for Hepatorenal Syndrome

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32MalaCards
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MalaCards organs/tissues related to Hepatorenal Syndrome:

32
Liver, Kidney, Bone, Heart, Breast, Skin

Animal Models for Hepatorenal Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hepatorenal Syndrome:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.9GNPAT, REN, AQP1, AQP2
2MP:00053698.2IL18, REN, EDN1, NPPA, TNF, CST3
3MP:00053678.1NPY, EDN1, REN, NAGLU, ACE, AQP1
4MP:00053817.8TNF, NPY, EDN3, EDN1, IL18, F2
5MP:00053857.5CST3, NPPA, EDN1, REN, NAGLU, IL18
6MP:00053976.9TNF, NPPA, REN, NAGLU, IL18, F2
7MP:00053866.5TNF, NPY, EDN3, REN, NAGLU, IL18
8MP:00036316.4GNPAT, CST3, TNF, NPY, EDN3, EDN1
9MP:00053786.3GNPAT, TNF, NPY, REN, NAGLU, IL18
10MP:00107686.0REN, EDN1, EDN3, TNF, GNPAT, NAGLU
11MP:00053765.9AQP2, GNPAT, CST3, TNF, NPY, NPPA

Publications for Hepatorenal Syndrome

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50PubMed
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Articles related to Hepatorenal Syndrome:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Impact of molecular adsorbent recirculating system on renal recovery in type-1 hepatorenal syndrome patients with chronic liver failure. (23425070)
2013
2
Renal failure in cirrhosis: prerenal azotemia, hepatorenal syndrome and acute tubular necrosis. (22492830)
2012
3
Terlipressin improves pulmonary pressures in cirrhotic patients with pulmonary hypertension and variceal bleeding or hepatorenal syndrome. (22893473)
2012
4
Hepatorenal syndrome: a critical update. (22447261)
2012
5
Terlipressin for hepatorenal syndrome. (22972083)
2012
6
Hepatorenal syndrome precipitated by infective endocarditis. (22041838)
2011
7
TIPS for the treatment of refractory ascites, hepatorenal syndrome and hepatic hydrothorax: a critical update. (20581246)
2010
8
Molecular adsorbent recirculating system is ineffective in the management of type 1 hepatorenal syndrome in patients with cirrhosis with ascites who have failed vasoconstrictor treatment. (19710033)
2010
9
Hepatic failure and hepatorenal syndrome secondary to erlotinib: a possible etiology of complications in a patient with pancreatic cancer. (20818124)
2010
10
Hepatorenal syndrome: a comprehensive overview for the critical care nurse. (20691386)
2010
11
Terlipressin for hepatorenal syndrome: continuous infusion as an alternative to i.v. bolus administration. (19631603)
2009
12
Effects of plasma expansion with albumin and paracentesis on haemodynamics and kidney function in critically ill cirrhotic patients with tense ascites and hepatorenal syndrome: a prospective uncontrolled trial. (18197961)
2008
13
A case report of hepatorenal syndrome treated with plasma diafiltration (selective plasma filtration with dialysis). (17845400)
2007
14
Terlipressin for hepatorenal syndrome. (17054242)
2006
15
New treatments of hepatorenal syndrome. (16850375)
2006
16
The hemodynamics of cirrhosis and the development of hepatorenal syndrome. (16498712)
2006
17
Current management of the hepatorenal syndrome. (16095965)
2005
18
The kidney in hepatorenal syndrome (I Part). (15061472)
2004
19
Review article: pathogenesis and pathophysiology of hepatorenal syndrome--is there scope for prevention? (15335398)
2004
20
The natural history and management of hepatorenal disorders: from pre-ascites to hepatorenal syndrome. (12737373)
2003
21
Hepatorenal syndrome. (15094702)
2003
22
Terlipressin-induced vasoconstriction reversed with N-acetylcysteine: a case for combined use in hepatorenal syndrome? (12454887)
2002
23
Hepatorenal syndrome. Definition, pathophysiology, and intervention. (12053838)
2002
24
Recovering from hepatorenal syndrome: reversibility of renal vasospasm demonstrated by Doppler ultrasound. (11961414)
2002
25
Improvement of multiple organ functions in hepatorenal syndrome during albumin dialysis with the molecular adsorbent recirculating system. (11778928)
2001
26
Improving prognosis in hepatorenal syndrome. (10896904)
2000
27
Hepatorenal Syndrome. (11096604)
2000
28
More therapy for hepatorenal syndrome. (10220524)
1999
29
Hepatorenal syndrome and its treatment today. (10503849)
1999
30
Primary induction with mycophenolate mofetil and corticosteroids in a liver transplant recipient with hepatorenal syndrome. (9475819)
1998
31
Beneficial effects of the 2-day administration of terlipressin in patients with cirrhosis and hepatorenal syndrome. (9824265)
1998
32
Transjugular intrahepatic portosystemic shunt in hepatorenal syndrome: effects on renal function and vasoactive systems. (9696006)
1998
33
Hepatorenal syndrome. (9308128)
1997
34
The atrial natriuretic peptide-renin-aldosterone system in hepatorenal syndrome. (9177611)
1996
35
The hepatorenal syndrome. (8611335)
1996
36
Fulminant hepatic failure, hepatorenal syndrome, and necrotizing pancreatitis after minocycline hepatotoxicity. (8470208)
1993
37
Hepatorenal syndrome. New perspectives in pathogenesis and treatment. (8357280)
1993
38
Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites. (8514039)
1993
39
Probable hepatorenal syndrome at presentation. (8420265)
1993
40
The reversal of the hepatorenal syndrome in four pediatric patients following successful orthotopic liver transplantation. (3551858)
1987
41
Hepatorenal syndrome complicating chronic lymphocytic leukemia. (3946451)
1986
42
Hepatorenal syndrome. (6914260)
1981
43
Hepatorenal syndrome. (7002455)
1980
44
The hepatorenal syndrome. (499720)
1979
45
Hepatorenal syndrome. Reversal with LeVeen shunt. (273754)
1978
46
Hepatorenal syndrome. Recovery after peritoneovenous shunt. (901096)
1977
47
The hepatorenal syndrome: recovery after portacaval shunt. (1094971)
1975
48
Renin substrate infusions in hepatorenal syndrome. (56050)
1975
49
Hepatorenal syndrome. (5786694)
1969
50
CURRENT CONCEPT OF THE HEPATORENAL SYNDROME. A CLINICO-PATHOLOGIC STUDY. (14077871)
1963

Genetic Variations for Hepatorenal Syndrome

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Expression for genes affiliated with Hepatorenal Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatorenal Syndrome

Search GEO for disease gene expression data for Hepatorenal Syndrome.

Pathways for genes affiliated with Hepatorenal Syndrome

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9AQP2, AQP1
29.7TNF
39.2ALB, F2, TNF

Compounds for genes affiliated with Hepatorenal Syndrome

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 183)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.0NPY, EDN3
2toki-shakuyaku-san4410.0REN, EDN1, NPPA
3losartan44 49 28 1112.9NPPA, EDN1, REN, ALB
4pge2449.9EDN3, REN, AQP2
551-cr-edta449.8ALB, CST3, NPPA, REN
6captopril44 28 49 59 1113.8CST3, REN, EDN1, EDN3
7ibopamine449.6NPPA, REN, ACE
8alacepril449.5REN, ACE, NPPA
9omapatrilat449.5REN, ACE, NPPA, EDN1
10cilazapril44 1110.5ACE, REN, EDN1, NPPA
11trandolapril44 1110.5NPPA, REN, ACE, EDN1
12fosinopril44 1110.5REN, ACE, NPPA, ALB
13enalaprilat449.4EDN1, NPPA, ACE, REN
14valsartan44 59 28 1112.4REN, ACE, ALB, EDN1
15quinapril44 1110.4ACE, REN, EDN1, NPPA
16inulin449.3REN, ALB, NAGLU, CST3, NPPA
17thiorphan44 28 1111.3NPPA, ACE, EDN1, EDN3
18desmopressin44 59 28 1112.3REN, AQP2, F2, NAGLU, NPPA
19hydrochlorothiazide44 49 28 11 2413.2REN, ALB, AQP2, ACE
20ramipril44 1110.2ALB, CST3, ACE, NPPA, REN
21cyclosporin a44 28 5911.2AQP2, F2, EDN1, CST3, NAGLU
22p-aminohippuric acid449.2NPPA, NAGLU, ALB
23diltiazem44 28 1111.2F2, EDN1, ACE, REN
24kininogen449.2ACE, CST3, NPPA, REN, F2
25lisinopril44 11 2411.2ACE, NPY, NPPA, REN, ALB
26spironolactone49 44 59 28 1113.2ALB, ACE, REN, NPPA
27carvedilol44 49 28 1112.1NPPA, ACE, REN, EDN1
28digoxin44 49 59 11 2413.1ACE, F2, REN, NPPA, CST3
29sodium nitroprusside449.1NPY, NPPA, EDN3, EDN1, REN, AQP1
30amlodipine44 49 11 2412.1REN, NPPA, ACE, ALB
31perindopril44 49 1111.0ACE, NAGLU, ALB, REN, NPPA
32phosphoramidon44 1110.0EDN3, NPPA, ACE, NPY, EDN1
33enalapril44 49 1110.8ALB, EDN1, NPPA, ACE, NAGLU, REN
34epinephrine44 11 2410.8NPY, NPPA, EDN1, REN, IL18, F2
35furosemide44 49 59 28 11 2413.8AQP2, ALB, ACE, NAGLU, REN, NPPA
36sodium44 249.7REN, AQP2, AQP1, ACE, NAGLU, EDN1
37potassium44 11 2410.6ACE, NAGLU, EDN3, AQP1, AQP2, REN
38homocysteine44 249.6ALB, CST3, MARS, NAGLU, IL18, F2
39glucose448.5AQP1, EDN3, NAGLU, REN, AQP2, NPY
40nifedipine44 49 28 1111.3NPPA, ACE, NPY, NAGLU, REN, EDN1
41indomethacin44 59 28 1111.2IL18, ALB, NPY, EDN3, EDN1, REN
42methotrexate44 49 1110.2TNF, ALB, CST3, IL18, NAGLU, F2
43arginine448.1AQP2, AQP1, REN, NPY, IL18, NPPA
44prostacyclin448.0TNF, ACE, REN, EDN3, NPPA, NPY
45alanine447.8ALB, F2, AQP2, NAGLU, IL18, AQP1
46vegf447.7EDN3, NPPA, CST3, EDN1, REN, IL18
47lactate447.7CST3, TNF, NPY, NAGLU, IL18, F2
48creatinine446.9ALB, CST3, NPY, NPPA, EDN1, REN
49calcium44 49 11 249.7IL18, ACE, AQP1, CST3, AQP2, NAGLU
50nitric oxide44 11 248.5IL18, ACE, AQP1, AQP2, REN, EDN3

GO Terms for genes affiliated with Hepatorenal Syndrome

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16Gene Ontology
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Cellular components related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.4EDN3, NPPA, NPY, TNF, EDN1, REN
2extracellular spaceGO:0056156.1ALB, CST3, TNF, NPY, NPPA, EDN3

Biological processes related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1nitric oxide transportGO:03018510.3EDN1, AQP1
2renal water transportGO:00309710.2AQP2, AQP1
3cellular response to mercury ionGO:07128810.2AQP1, AQP2
4peptide hormone secretionGO:03007210.2EDN3, EDN1
5vein smooth muscle contractionGO:01482610.2EDN3, EDN1
6regulation of systemic arterial blood pressure by endothelinGO:00310010.2EDN3, EDN1
7glycerol transportGO:01579310.2AQP1, AQP2
8artery smooth muscle contractionGO:01482410.2EDN1, EDN3
9cellular response to copper ionGO:07128010.1AQP2, AQP1
10inositol phosphate-mediated signalingGO:04801610.1EDN3, EDN1
11cGMP biosynthetic processGO:00618210.1NPPA, AQP1
12positive regulation of hormone secretionGO:04688710.1EDN1, EDN3
13cell volume homeostasisGO:00688410.0AQP1, AQP2
14positive regulation of heart rateGO:01046010.0EDN1, EDN3
15vasoconstrictionGO:0423109.9EDN1, EDN3
16angiotensin maturationGO:0020039.7ACE, REN
17regulation of vasoconstrictionGO:0192299.6ACE, EDN1, EDN3
18response to lipopolysaccharideGO:0324969.6EDN1, REN, AQP2
19positive regulation of mitosisGO:0458409.4TNF, EDN3, EDN1
20positive regulation of MAP kinase activityGO:0434069.4EDN1, EDN3, TNF
21response to salt stressGO:0096519.4AQP2, TNF
22regulation of blood pressureGO:0082179.3ACE, REN, NPPA, NPY
23positive regulation of chemokine productionGO:0327229.0IL18, TNF

Molecular functions related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycerol transmembrane transporter activityGO:0151689.8AQP1, AQP2
2hormone activityGO:0051799.7EDN1, EDN3, NPPA
3water transmembrane transporter activityGO:0053729.6AQP2, AQP1
4receptor bindingGO:0051028.5F2, REN, EDN3, NPPA, NPY, GNPAT

Products for genes affiliated with Hepatorenal Syndrome

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Sources for Hepatorenal Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet