MCID: HPT014
MIFTS: 54

Hepatorenal Syndrome malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Hepatorenal Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hepatorenal syndrome (often abbreviated HRS) is a life-threatening medical condition that consists of... more...

MalaCards: Hepatorenal Syndrome is related to hepatitis and liver cirrhosis. An important gene associated with Hepatorenal Syndrome is ALB (albumin), and among its related pathways are Passive Transport by Aquaporins and MicroRNAs in cardiomyocyte hypertrophy. The compounds norepinephrine and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and skin, and related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Hepatorenal Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

hepatorenal syndrome 8 42 44 60


External Ids:

Disease Ontology8 DOID:11823
MeSH34 D006530
SNOMED-CT56 51292008
ICD9CM27 572.4
ICD1025 K76.7

Related Diseases for Hepatorenal Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hepatorenal Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.9IL18, F2
2liver cirrhosis30.8CST3, NPY, NPPA, EDN3, EDN1, REN
3alcoholic hepatitis30.6F2, TNF
4hepatitis a30.4F2
5peritonitis30.4AQP1, ALB, F2, TNF
6acute liver failure30.3F2, ALB
7hypertension30.3ALB, ACE, F2, REN, EDN1, NPPA
8pancreatitis30.2ALB
9hepatitis c30.2TNF, IL18, F2
10disseminated intravascular coagulation29.9F2
11hepatopulmonary syndrome29.9EDN1, ALB
12leukemia29.9TNF
13portal hypertension29.9EDN1, F2, ALB
14acute kidney tubular necrosis29.9NAGLU, NPPA
15hepatitis b29.9IL18, F2, ALB
16glomerulonephritis29.9EDN3, NAGLU, ALB
17ischemia29.9CST3, EDN1, NAGLU
18pre-eclampsia29.9CST3, NPPA, EDN1, REN, NAGLU, IL18
19liver disease10.5
20obstructive jaundice10.2
21alcoholic liver cirrhosis10.2
22n syndrome10.2
23good syndrome10.1
24uremia10.0ALB
25neuropathy10.0ALB
26wilms tumor10.0REN
27sickle cell disease10.0EDN1
28diarrhea10.0ALB
29meningitis10.0ALB
30proliferative diabetic retinopathy10.0EDN1
31hypoaldosteronism10.0REN
32lung cancer10.0ALB
33thromboembolism10.0F2
34skin disease10.0ALB
35hyperparathyroidism10.0ALB
36diabetes insipidus10.0AQP2
37short bowel syndrome10.0ALB
38portal vein thrombosis10.0F2
39hypothyroidism10.0CST3
40viral hepatitis10.0F2
41acute pancreatitis10.0IL18
42adenocarcinoma10.0AQP1
43glioblastoma multiforme10.0AQP1
44gingivitis10.0CST3
45mitral valve disease10.0NPPA
46addison's disease10.0REN
47allergic rhinitis10.0IL18
48dementia10.0CST3
49ovarian hyperstimulation syndrome10.0ALB, REN
50anorexia nervosa10.0NPY

Graphical network of the top 20 diseases related to Hepatorenal Syndrome:



Diseases related to hepatorenal syndrome

Clinical Features for Hepatorenal Syndrome

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Drugs & Therapeutics for Hepatorenal Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hepatorenal Syndrome

Drug clinical trials:

Search ClinicalTrials for Hepatorenal Syndrome

Search NIH Clinical Center for Hepatorenal Syndrome

Search CenterWatch for Hepatorenal Syndrome

Genetic Tests for Hepatorenal Syndrome

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Anatomical Context for Hepatorenal Syndrome

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32MalaCards
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MalaCards organs/tissues related to Hepatorenal Syndrome:

32
Liver, Kidney, Skin, Bone, Heart, Breast

Animal Models for Hepatorenal Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hepatorenal Syndrome:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.9GNPAT, REN, AQP1, AQP2
2MP:00053698.2IL18, REN, EDN1, NPPA, TNF, CST3
3MP:00053678.1NPY, EDN1, REN, NAGLU, ACE, AQP1
4MP:00053817.8TNF, NPY, EDN3, EDN1, IL18, F2
5MP:00053857.5CST3, NPPA, EDN1, REN, NAGLU, IL18
6MP:00053976.9TNF, NPPA, REN, NAGLU, IL18, F2
7MP:00053866.5TNF, NPY, EDN3, REN, NAGLU, IL18
8MP:00036316.4GNPAT, CST3, TNF, NPY, EDN3, EDN1
9MP:00053786.3GNPAT, TNF, NPY, REN, NAGLU, IL18
10MP:00107686.0REN, EDN1, EDN3, TNF, GNPAT, NAGLU
11MP:00053765.9AQP2, GNPAT, CST3, TNF, NPY, NPPA

Publications for Hepatorenal Syndrome

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50PubMed
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Articles related to Hepatorenal Syndrome:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Management and outcome in hepatorenal syndrome: need for renal replacement therapy in non-transplanted patients. (23934619)
2013
2
Living donor liver transplantation for hepatorenal syndrome: to do or not to do? That is the question. (22740330)
2012
3
Hepatorenal syndrome: the 8th International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. (22322077)
2012
4
Impact of the etiology of acute kidney injury on outcomes following liver transplantation: acute tubular necrosis versus hepatorenal syndrome. (22250075)
2012
5
Liver transplant outcomes for patients with hepatorenal syndrome treated with pretransplant vasoconstrictors and albumin. (21544034)
2011
6
Hepatorenal syndrome. (21480763)
2011
7
Severe hepatotoxicity and probable hepatorenal syndrome associated with sulfadiazine. (21546639)
2011
8
Impact of hepatorenal syndrome and liver transplantation. (21505341)
2011
9
Hepatorenal syndrome: beyond liver failure. (20431446)
2010
10
The management of hepatorenal syndrome. (19305378)
2009
11
Long-term outcome of patients treated with terlipressin for types 1 and 2 hepatorenal syndrome. (17784863)
2008
12
Vasoconstrictor therapy for the hepatorenal syndrome. (18471529)
2008
13
Hepatic failure and hepatorenal syndrome secondary to erlotinib. Safety reminder. (18981559)
2008
14
Noradrenalin vs terlipressin in patients with hepatorenal syndrome: a prospective, randomized, unblinded, pilot study. (17560680)
2007
15
Hepatorenal syndrome: pathogenesis and treatment]. (17760404)
2007
16
Octreotide/Midodrine therapy significantly improves renal function and 30-day survival in patients with type 1 hepatorenal syndrome. (17235705)
2007
17
Immediate recovery of renal function after orthotopic liver transplantation in a patient with hepatorenal syndrome requiring hemodialysis for more than 8 months. (17362778)
2007
18
Diagnostics and therapy of hepatorenal syndrome. Recommendations of of the working group on portal hypertension of the Czech Hepatology Society and the J. E. Purkinje Czech Medical Society]. (16871772)
2006
19
Hepatorenal syndrome. (16971267)
2006
20
Hepatorenal syndrome: a dreaded complication of end-stage liver disease. (15667508)
2005
21
Hepatorenal syndrome: pathophysiology and treatment. (12240852)
2002
22
New challenge of hepatorenal syndrome: prevention and treatment. (11732014)
2001
23
The time is right for the use of liver dialysis devices in patients with hepatorenal syndrome. (10997361)
2000
24
Hepatorenal syndrome. (11232202)
2000
25
Improvement of hepatorenal syndrome with extracorporeal albumin dialysis MARS: results of a prospective, randomized, controlled clinical trial. (10827226)
2000
26
Diagnosis and treatment of hepatorenal syndrome. (11139348)
2000
27
Update on peripheral arterial vasodilation, ascites and hepatorenal syndrome in cirrhosis. (11110623)
2000
28
Octreotide in the treatment of the hepatorenal syndrome in cirrhotic patients. (9927168)
1999
29
Pathogenetic factors and clinical elements in ascites and hepatorenal syndrome during liver cirrhosis. (10638019)
1999
30
Reversal of hepatorenal syndrome with the combination of norepinephrine and dopamine. (8001372)
1995
31
Sequential treatment of hepatorenal syndrome and posthepatic cirrhosis by intrahepatic portosystemic shunt (TIPSS) and liver transplantation. (8847056)
1995
32
Hepatorenal syndrome: emerging perspectives of pathophysiology and therapy. (8068872)
1994
33
Plasma endothelin and the hepatorenal syndrome. (8505957)
1993
34
A hepatorenal depressor reflex: a possible clue to the pathogenesis of the hepatorenal syndrome. (1916677)
1991
35
Systemic and renal production of thromboxane A2 and prostacyclin in decompensated liver disease and hepatorenal syndrome. (2001805)
1991
36
Prostaglandin analogues and reversal of hepatorenal syndrome: fact or fiction? (1909087)
1991
37
Continuous arteriovenous hemofiltration in the patient with hepatorenal syndrome. A case study. (2357307)
1990
38
The hepatorenal syndrome. (2195263)
1990
39
Immunohistochemical distribution of renal prostaglandin endoperoxide synthase and prostacyclin synthase: diminished endoperoxide synthase in the hepatorenal syndrome. (3111964)
1987
40
Pathogenesis of ascites formation and hepatorenal syndrome: humoral and hemodynamic factors. (3544227)
1986
41
New trends in hepatorenal syndrome. (3867784)
1985
42
Hepatorenal syndrome associated with obstructive jaundice. (4067231)
1985
43
Peritonitis in a patient with hepatorenal syndrome. (6731713)
1984
44
Therapeutic trial of thromboxane synthesis inhibition in the hepatorenal syndrome. (6593268)
1984
45
Hepatorenal syndrome or hepatic nephropathy? (6102683)
1980
46
Treatment of hepatorenal syndrome. (7362005)
1980
47
Effects of a portacaval or peritoneovenous shunt on renin in the hepatorenal syndrome. (491398)
1979
48
Survival associated with hepatorenal syndrome. (104394)
1979
49
Diagnosis and therapy of the hepatorenal syndrome: a tentative classification. (4806037)
1973
50
Recovery from hepatorenal syndrome after successful orthotopic liver transplantation. (4377034)
1973

Genetic Variations for Hepatorenal Syndrome

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Expression for genes affiliated with Hepatorenal Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatorenal Syndrome

Search GEO for disease gene expression data for Hepatorenal Syndrome.

Pathways for genes affiliated with Hepatorenal Syndrome

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9AQP2, AQP1
29.7TNF
39.2ALB, F2, TNF

Compounds for genes affiliated with Hepatorenal Syndrome

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 183)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.0NPY, EDN3
2toki-shakuyaku-san4410.0REN, EDN1, NPPA
3losartan44 49 28 1112.9NPPA, EDN1, REN, ALB
4pge2449.9EDN3, REN, AQP2
551-cr-edta449.8ALB, CST3, NPPA, REN
6captopril44 28 49 59 1113.8CST3, REN, EDN1, EDN3
7ibopamine449.6NPPA, REN, ACE
8alacepril449.5REN, ACE, NPPA
9omapatrilat449.5REN, ACE, NPPA, EDN1
10cilazapril44 1110.5ACE, REN, EDN1, NPPA
11trandolapril44 1110.5NPPA, REN, ACE, EDN1
12fosinopril44 1110.5REN, ACE, NPPA, ALB
13enalaprilat449.4EDN1, NPPA, ACE, REN
14valsartan44 59 28 1112.4REN, ACE, ALB, EDN1
15quinapril44 1110.4ACE, REN, EDN1, NPPA
16inulin449.3REN, ALB, NAGLU, CST3, NPPA
17thiorphan44 28 1111.3NPPA, ACE, EDN1, EDN3
18desmopressin44 59 28 1112.3REN, AQP2, F2, NAGLU, NPPA
19hydrochlorothiazide44 49 28 11 2413.2REN, ALB, AQP2, ACE
20ramipril44 1110.2ALB, CST3, ACE, NPPA, REN
21cyclosporin a44 28 5911.2AQP2, F2, EDN1, CST3, NAGLU
22p-aminohippuric acid449.2NPPA, NAGLU, ALB
23diltiazem44 28 1111.2F2, EDN1, ACE, REN
24kininogen449.2ACE, CST3, NPPA, REN, F2
25lisinopril44 11 2411.2ACE, NPY, NPPA, REN, ALB
26spironolactone49 44 59 28 1113.2ALB, ACE, REN, NPPA
27carvedilol44 49 28 1112.1NPPA, ACE, REN, EDN1
28digoxin44 49 59 11 2413.1ACE, F2, REN, NPPA, CST3
29sodium nitroprusside449.1NPY, NPPA, EDN3, EDN1, REN, AQP1
30amlodipine44 49 11 2412.1REN, NPPA, ACE, ALB
31perindopril44 49 1111.0ACE, NAGLU, ALB, REN, NPPA
32phosphoramidon44 1110.0EDN3, NPPA, ACE, NPY, EDN1
33enalapril44 49 1110.8ALB, EDN1, NPPA, ACE, NAGLU, REN
34epinephrine44 11 2410.8NPY, NPPA, EDN1, REN, IL18, F2
35furosemide44 49 59 28 11 2413.8AQP2, ALB, ACE, NAGLU, REN, NPPA
36sodium44 249.7REN, AQP2, AQP1, ACE, NAGLU, EDN1
37potassium44 11 2410.6ACE, NAGLU, EDN3, AQP1, AQP2, REN
38homocysteine44 249.6ALB, CST3, MARS, NAGLU, IL18, F2
39glucose448.5AQP1, EDN3, NAGLU, REN, AQP2, NPY
40nifedipine44 49 28 1111.3NPPA, ACE, NPY, NAGLU, REN, EDN1
41indomethacin44 59 28 1111.2IL18, ALB, NPY, EDN3, EDN1, REN
42methotrexate44 49 1110.2TNF, ALB, CST3, IL18, NAGLU, F2
43arginine448.1AQP2, AQP1, REN, NPY, IL18, NPPA
44prostacyclin448.0TNF, ACE, REN, EDN3, NPPA, NPY
45alanine447.8ALB, F2, AQP2, NAGLU, IL18, AQP1
46vegf447.7EDN3, NPPA, CST3, EDN1, REN, IL18
47lactate447.7CST3, TNF, NPY, NAGLU, IL18, F2
48creatinine446.9ALB, CST3, NPY, NPPA, EDN1, REN
49calcium44 49 11 249.7IL18, ACE, AQP1, CST3, AQP2, NAGLU
50nitric oxide44 11 248.5IL18, ACE, AQP1, AQP2, REN, EDN3

GO Terms for genes affiliated with Hepatorenal Syndrome

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16Gene Ontology
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Cellular components related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.4CST3, ACE, F2, IL18, REN, EDN1
2extracellular spaceGO:0056156.1CST3, ACE, F2, IL18, REN, EDN1

Biological processes related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1nitric oxide transportGO:03018510.3EDN1, AQP1
2renal water transportGO:00309710.2AQP2, AQP1
3cellular response to mercury ionGO:07128810.2AQP1, AQP2
4peptide hormone secretionGO:03007210.2EDN3, EDN1
5vein smooth muscle contractionGO:01482610.2EDN3, EDN1
6regulation of systemic arterial blood pressure by endothelinGO:00310010.2EDN3, EDN1
7glycerol transportGO:01579310.2AQP1, AQP2
8artery smooth muscle contractionGO:01482410.2EDN1, EDN3
9cellular response to copper ionGO:07128010.1AQP2, AQP1
10inositol phosphate-mediated signalingGO:04801610.1EDN3, EDN1
11cGMP biosynthetic processGO:00618210.1NPPA, AQP1
12positive regulation of hormone secretionGO:04688710.1EDN1, EDN3
13cell volume homeostasisGO:00688410.0AQP1, AQP2
14positive regulation of heart rateGO:01046010.0EDN1, EDN3
15vasoconstrictionGO:0423109.9EDN1, EDN3
16angiotensin maturationGO:0020039.7ACE, REN
17regulation of vasoconstrictionGO:0192299.6ACE, EDN1, EDN3
18response to lipopolysaccharideGO:0324969.6EDN1, REN, AQP2
19positive regulation of mitosisGO:0458409.4TNF, EDN3, EDN1
20positive regulation of MAP kinase activityGO:0434069.4EDN1, EDN3, TNF
21response to salt stressGO:0096519.4AQP2, TNF
22regulation of blood pressureGO:0082179.3ACE, REN, NPPA, NPY
23positive regulation of chemokine productionGO:0327229.0IL18, TNF

Molecular functions related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycerol transmembrane transporter activityGO:0151689.8AQP1, AQP2
2hormone activityGO:0051799.7EDN1, EDN3, NPPA
3water transmembrane transporter activityGO:0053729.6AQP2, AQP1
4receptor bindingGO:0051028.5F2, REN, EDN3, NPPA, NPY, GNPAT

Products for genes affiliated with Hepatorenal Syndrome

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Sources for Hepatorenal Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet