MCID: HPT014
MIFTS: 49

Hepatorenal Syndrome malady

Gastrointestinal, Liver categories

Summaries for Hepatorenal Syndrome

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Hepatorenal syndrome (often abbreviated HRS) is a life-threatening medical condition that consists of... more...

MalaCards: Hepatorenal Syndrome is related to hepatitis a and alcoholic hepatitis. An important gene associated with Hepatorenal Syndrome is ALB (albumin), and among its related pathways are Passive Transport by Aquaporins and MicroRNAs in cardiomyocyte hypertrophy. The compounds norepinephrine and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and kidney, and related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Hepatorenal Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Liver


Aliases & Descriptions:

hepatorenal syndrome 8 43 45 61


External Ids:

Disease Ontology8 DOID:11823
MeSH35 D006530
SNOMED-CT57 51292008
ICD9CM27 572.4
ICD1025 K76.7

Related Diseases for Hepatorenal Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hepatorenal Syndrome:



Diseases related to hepatorenal syndrome

Clinical Features for Hepatorenal Syndrome

Drugs & Therapeutics for Hepatorenal Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hepatorenal Syndrome

Drug clinical trials:

Search ClinicalTrials for Hepatorenal Syndrome

Search NIH Clinical Center for Hepatorenal Syndrome

Search CenterWatch for Hepatorenal Syndrome

Genetic Tests for Hepatorenal Syndrome

Anatomical Context for Hepatorenal Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Hepatorenal Syndrome:

33
Bone marrow, Heart, Kidney, Liver, Breast, Skin, B cells, Fetal liver

Animal Models for Hepatorenal Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hepatorenal Syndrome

Sources:
51PubMed
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Articles related to Hepatorenal Syndrome:

(show top 50)    (show all 509)
idTitleAuthorsYear
1
Results of pretransplant treatment of hepatorenal syndrome with terlipressin. (23652609)
2013
2
Native renal function after combined liver-kidney transplant for type 1 hepatorenal syndrome: initial report on the use of postoperative Technetium-99 m-mercaptoacetyltriglycine scans. (23384317)
2013
3
Serum sodium identifies patients with cirrhosis at high risk of hepatorenal syndrome. (23696114)
2013
4
Hepatorenal syndrome in the intensive care unit. (21859679)
2013
5
Relative adrenal insufficiency in decompensated cirrhosis: Relationship to short-term risk of severe sepsis, hepatorenal syndrome, and death. (23728792)
2013
6
Renal and circulatory effects of large volume plasma expansion in patients with hepatorenal syndrome type 1. (22345341)
2012
7
Medical management of hepatorenal syndrome. (22942176)
2012
8
Hepatorenal syndrome: do the vasoconstrictors work? (21893275)
2011
9
Correlation between albuminemia, natremia and survival rates in patients with hepatorenal syndrome. (21892531)
2011
10
Terlipressin in hepatorenal syndrome: Evidence for present indications. (21199521)
2011
11
Management of hepatorenal syndrome in patients with cirrhosis. (21826080)
2011
12
Optimal management of hepatorenal syndrome in patients with cirrhosis. (24367209)
2010
13
Does hepatorenal syndrome affect the result of liver transplantation? Clinical observations. (20832544)
2010
14
Terlipressin in 30 patients with hepatorenal syndrome: results of a retrospective study. (19156588)
2009
15
Lack of renal improvement with nonselective endothelin antagonism with tezosentan in type 2 hepatorenal syndrome. (17886336)
2008
16
Single pass albumin dialysis in hepatorenal syndrome. (18445918)
2008
17
Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome. (18027874)
2007
18
Hepatorenal syndrome: resolution of ascites by continuous renal replacement therapy in an alcoholic coinfected with hepatitis B, C, and human immunodeficiency viruses. (16501243)
2006
19
Meta-analysis: terlipressin therapy for the hepatorenal syndrome. (16948805)
2006
20
Role of albumin in the treatment of hepatorenal syndrome in cirrhosis]. (15710088)
2005
21
Type-2 hepatorenal syndrome and refractory ascites: role of transjugular intrahepatic portosystemic stent-shunt in eighteen patients with advanced cirrhosis awaiting orthotopic liver transplantation. (14696397)
2003
22
Beneficial effects of terlipressin in hepatorenal syndrome: a prospective, randomized placebo-controlled clinical trial. (12542598)
2003
23
Albumin versus crystalloid therapy in the management of hepatorenal syndrome: a model for using meta analysis in cost effectiveness studies and the design of clinical trials. (14728474)
2003
24
Terlipressin and albumin combination treatment in hepatorenal syndrome. (15244209)
2003
25
Octreotide in hepatorenal syndrome: a randomized, double-blind, placebo-controlled, crossover study. (12830007)
2003
26
Effect of terlipressin (Glypressin) on hepatorenal syndrome in cirrhotic patients: results of a multicentre pilot study. (11981339)
2002
27
Current management and novel therapeutic strategies for refractory ascites and hepatorenal syndrome. (11391027)
2001
28
Reversibility of hepatorenal syndrome in an anuric patient with child C cirrhosis requiring haemodialysis for 7 weeks. (10862650)
2000
29
Prolonged infusion of ornithine plus dopamine in the treatment of the hepatorenal syndrome: a breakthrough? (11151911)
2000
30
Review article: pharmacological treatment of the hepatorenal syndrome in cirrhotic patients. (10792112)
2000
31
Hepatorenal syndrome. (10915194)
2000
32
Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide. (10347109)
1999
33
Medical treatment of hepatorenal syndrome. (10967862)
1999
34
Fetal enterolithiasis and anhydramnios; due to in utero hepatorenal syndrome? (9854732)
1998
35
Treatment with terlipressin as a bridge to liver transplantation in a patient with hepatorenal syndrome. (9658623)
1998
36
Circadian rhythm of arginine vasopressin in hepatorenal syndrome. (9453401)
1998
37
Hepatorenal syndrome: combined liver kidney transplants versus isolated liver transplant. (9422417)
1997
38
Improvement of hepatorenal syndrome by transjugular intrahepatic portosystemic shunt. (7611221)
1995
39
Low-dose ornipressin improves renal function in the hepatorenal syndrome. (8306699)
1994
40
Plasma endothelin and the hepatorenal syndrome. (8505956)
1993
41
Assessment of bilirubin clearance capacity of a newly developed ion-exchange adsorption column and its possible use as a supportive therapy in hepatorenal syndrome. (2345158)
1990
42
Prostaglandins and the treatment of hepatorenal syndrome in cirrhosis. (2254624)
1990
43
Analysis of cysteinyl leukotrienes in human urine: enhanced excretion in patients with liver cirrhosis and hepatorenal syndrome. (2499462)
1989
44
Hepatorenal syndrome: a disease mediated by the intrarenal action of renin. (778556)
1976
45
The hepatorenal syndrome. (781880)
1976
46
Transplantation of cadaveric kidneys from patients with hepatorenal syndrome. Evidence for the functionalnature of renal failure in advanced liver disease. (4890476)
1969
47
The hepatorenal syndrome; a review and description of two unusual cases. (13125736)
1954
48
The hepatorenal syndrome. (13181948)
1954
49
The hepatorenal syndrome complicating pregnancy. (14952522)
1952
50
The experimental production of the hepatorenal syndrome in dogs. (14828487)
1950

Genetic Variations for Hepatorenal Syndrome

Expression for genes affiliated with Hepatorenal Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatorenal Syndrome

Search GEO for disease gene expression data for Hepatorenal Syndrome.

Pathways for genes affiliated with Hepatorenal Syndrome

Sources:
54Reactome, 38NCBI BioSystems Database
See all sources

Pathways related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9AQP2, AQP1
29.7TNF
39.2ALB, F2, TNF

Compounds for genes affiliated with Hepatorenal Syndrome

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 183)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2412.0NPY, EDN3
2toki-shakuyaku-san4510.0REN, EDN1, NPPA
3losartan45 50 29 1112.9NPPA, EDN1, REN, ALB
4pge2459.9EDN3, REN, AQP2
551-cr-edta459.8ALB, CST3, NPPA, REN
6captopril45 29 50 60 1113.8CST3, REN, EDN1, EDN3
7ibopamine459.6NPPA, REN, ACE
8alacepril459.5REN, ACE, NPPA
9omapatrilat459.5REN, ACE, NPPA, EDN1
10cilazapril45 1110.5ACE, REN, EDN1, NPPA
11trandolapril45 1110.5NPPA, REN, ACE, EDN1
12fosinopril45 1110.5REN, ACE, NPPA, ALB
13enalaprilat459.4EDN1, NPPA, ACE, REN
14valsartan45 60 29 1112.4REN, ACE, ALB, EDN1
15quinapril45 1110.4ACE, REN, EDN1, NPPA
16inulin459.3REN, ALB, NAGLU, CST3, NPPA
17thiorphan45 29 1111.3NPPA, ACE, EDN1, EDN3
18desmopressin45 60 29 1112.3REN, AQP2, F2, NAGLU, NPPA
19hydrochlorothiazide45 50 29 11 2413.2REN, ALB, AQP2, ACE
20ramipril45 1110.2ALB, CST3, ACE, NPPA, REN
21cyclosporin a45 29 6011.2AQP2, F2, EDN1, CST3, NAGLU
22p-aminohippuric acid459.2NPPA, NAGLU, ALB
23diltiazem45 29 1111.2F2, EDN1, ACE, REN
24kininogen459.2ACE, CST3, NPPA, REN, F2
25lisinopril45 11 2411.2ACE, NPY, NPPA, REN, ALB
26spironolactone50 45 60 29 1113.2ALB, ACE, REN, NPPA
27carvedilol45 50 29 1112.1NPPA, ACE, REN, EDN1
28digoxin45 50 60 11 2413.1ACE, F2, REN, NPPA, CST3
29sodium nitroprusside459.1NPY, NPPA, EDN3, EDN1, REN, AQP1
30amlodipine45 50 11 2412.1REN, NPPA, ACE, ALB
31perindopril45 50 1111.0ACE, NAGLU, ALB, REN, NPPA
32phosphoramidon45 1110.0EDN3, NPPA, ACE, NPY, EDN1
33enalapril45 50 1110.8ALB, EDN1, NPPA, ACE, NAGLU, REN
34epinephrine45 11 2410.8NPY, NPPA, EDN1, REN, IL18, F2
35furosemide45 50 60 29 11 2413.8AQP2, ALB, ACE, NAGLU, REN, NPPA
36sodium45 249.7REN, AQP2, AQP1, ACE, NAGLU, EDN1
37potassium45 11 2410.6ACE, NAGLU, EDN3, AQP1, AQP2, REN
38homocysteine45 249.6ALB, CST3, MARS, NAGLU, IL18, F2
39glucose458.5AQP1, EDN3, NAGLU, REN, AQP2, NPY
40nifedipine45 50 29 1111.3NPPA, ACE, NPY, NAGLU, REN, EDN1
41indomethacin45 60 29 1111.2IL18, ALB, NPY, EDN3, EDN1, REN
42methotrexate45 50 1110.2TNF, ALB, CST3, IL18, NAGLU, F2
43arginine458.1AQP2, AQP1, REN, NPY, IL18, NPPA
44prostacyclin458.0TNF, ACE, REN, EDN3, NPPA, NPY
45alanine457.8ALB, F2, AQP2, NAGLU, IL18, AQP1
46vegf457.7EDN3, NPPA, CST3, EDN1, REN, IL18
47lactate457.7CST3, TNF, NPY, NAGLU, IL18, F2
48creatinine456.9ALB, CST3, NPY, NPPA, EDN1, REN
49calcium45 50 11 249.7IL18, ACE, AQP1, CST3, AQP2, NAGLU
50nitric oxide45 11 248.5IL18, ACE, AQP1, AQP2, REN, EDN3

GO Terms for genes affiliated with Hepatorenal Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.4CST3, ACE, F2, IL18, REN, EDN1
2extracellular spaceGO:0056156.1CST3, ACE, F2, IL18, REN, EDN1

Biological processes related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1nitric oxide transportGO:03018510.3EDN1, AQP1
2renal water transportGO:00309710.2AQP2, AQP1
3cellular response to mercury ionGO:07128810.2AQP1, AQP2
4peptide hormone secretionGO:03007210.2EDN3, EDN1
5vein smooth muscle contractionGO:01482610.2EDN3, EDN1
6regulation of systemic arterial blood pressure by endothelinGO:00310010.2EDN3, EDN1
7glycerol transportGO:01579310.2AQP1, AQP2
8artery smooth muscle contractionGO:01482410.2EDN1, EDN3
9cellular response to copper ionGO:07128010.1AQP2, AQP1
10inositol phosphate-mediated signalingGO:04801610.1EDN3, EDN1
11cGMP biosynthetic processGO:00618210.1NPPA, AQP1
12positive regulation of hormone secretionGO:04688710.1EDN1, EDN3
13cell volume homeostasisGO:00688410.0AQP1, AQP2
14positive regulation of heart rateGO:01046010.0EDN1, EDN3
15vasoconstrictionGO:0423109.9EDN1, EDN3
16angiotensin maturationGO:0020039.7ACE, REN
17regulation of vasoconstrictionGO:0192299.6ACE, EDN1, EDN3
18response to lipopolysaccharideGO:0324969.6EDN1, REN, AQP2
19positive regulation of mitosisGO:0458409.4TNF, EDN3, EDN1
20positive regulation of MAP kinase activityGO:0434069.4EDN1, EDN3, TNF
21response to salt stressGO:0096519.4AQP2, TNF
22regulation of blood pressureGO:0082179.3ACE, REN, NPPA, NPY
23positive regulation of chemokine productionGO:0327229.0IL18, TNF

Molecular functions related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycerol transmembrane transporter activityGO:0151689.8AQP1, AQP2
2hormone activityGO:0051799.7EDN1, EDN3, NPPA
3water transmembrane transporter activityGO:0053729.6AQP2, AQP1
4receptor bindingGO:0051028.5F2, REN, EDN3, NPPA, NPY, GNPAT

Products for genes affiliated with Hepatorenal Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatorenal Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet