MCID: HPT014
MIFTS: 57

Hepatorenal Syndrome malady

Rare diseases, Gastrointestinal diseases, Nephrological diseases, Liver diseases categories
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Summaries for Hepatorenal Syndrome

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Wikipedia:65 Hepatorenal syndrome (often abbreviated HRS) is a life-threatening medical condition that consists of... more...

MalaCards based summary: Hepatorenal Syndrome is related to alcoholic hepatitis and alcoholic liver cirrhosis. An important gene associated with Hepatorenal Syndrome is ALB (albumin), and among its related pathways are Development Angiotensin activation of ERK and Gastrin-CREB signalling pathway via PKC and MAPK. The compounds toki-shakuyaku-san and 51-cr-edta have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone, and related mouse phenotypes are adipose tissue and muscle.

Aliases & Classifications for Hepatorenal Syndrome

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Hepatorenal Syndrome, Aliases & Descriptions:

Name: Hepatorenal Syndrome 8 42 44 62


Classifications:



External Ids:

Disease Ontology8 DOID:11823
MeSH34 D006530
SNOMED-CT57 51292008
ICD9CM27 572.4
ICD1025 K76.7

Related Diseases for Hepatorenal Syndrome

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Diseases related to Hepatorenal Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1alcoholic hepatitis31.1F2, TNF
2alcoholic liver cirrhosis30.8ALB, F2
3hepatopulmonary syndrome30.7EDN1, ALB
4acute liver failure30.7F2, ALB
5peritonitis30.6F2, TNF, AQP1, ALB
6hepatitis b30.5ALB, F2
7pulmonary hypertension30.5NPPA, EDN3, EDN1
8glomerulonephritis30.2ALB, NAGLU, EDN3
9sepsis30.2F2, TNF, IL18, CST3, ALB
10hepatitis c30.1ALB, IL18, F2
11liver cirrhosis29.9CST3, REN, AQP2, EDN3, EDN1, F2
12hypertension29.3F2, EDN1, NPY, NPPA, ALB, CST3
13pre-eclampsia29.2F2, EDN1, AQP2, NAGLU, REN, IL18
14hepatitis10.7
15hypoaldosteronism10.6REN
16congestive heart failure10.6REN
17fibromuscular dysplasia10.6REN
18liver disease10.5
19mitral valve disease10.5NPPA
20sick sinus syndrome10.5NPPA
21dysfibrinogenemia10.5F2
22hypersplenism10.5F2
23diabetes insipidus10.5AQP2
24polyhydramnios10.5AQP1
25vascular disease10.5TNF
26varicose veins10.5F2, ALB
27esophageal varix10.4ALB, F2
28cor pulmonale10.4EDN1, NPPA
29ovarian hyperstimulation syndrome10.4REN, ALB
30inappropriate adh syndrome10.4NPPA, AQP2
31low renin hypertension10.4REN, EDN1
32syndrome of inappropriate antidiuretic hormone10.4AQP2, NPPA
33conn's syndrome10.4REN, NPPA
34acute pyelonephritis10.4NAGLU
35hydronephrosis10.4NAGLU
36chronic pyelonephritis10.4NAGLU
37primary pulmonary hypertension10.4EDN1, NPPA
38brain edema10.4ALB, AQP1
39hepatic encephalopathy10.4F2, ALB
40pyelonephritis10.4NAGLU
41nephrogenic diabetes insipidus10.4AQP2, AQP1
42pulmonary embolism10.3ALB, F2
43intestinal obstruction10.3EDN3, ALB
44portal hypertension10.3F2, EDN1, ALB
45bilirubin metabolic disorder10.3F2, ALB
46metabolic acidosis10.3AQP2, REN, ALB
47anuria10.3ACE
48acute kidney tubular necrosis10.3NAGLU, NPPA
49diabetic angiopathy10.3EDN1, NAGLU
50hyperhomocysteinemia10.3F2, CST3, ALB

Graphical network of the top 20 diseases related to Hepatorenal Syndrome:



Diseases related to hepatorenal syndrome

Symptoms for Hepatorenal Syndrome

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Drugs & Therapeutics for Hepatorenal Syndrome

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Drug clinical trials:

Search ClinicalTrials for Hepatorenal Syndrome

Search NIH Clinical Center for Hepatorenal Syndrome

Genetic Tests for Hepatorenal Syndrome

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Anatomical Context for Hepatorenal Syndrome

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MalaCards organs/tissues related to Hepatorenal Syndrome:

32
Liver, Kidney, Bone, Heart, Breast, Skin, Neutrophil

Animal Models for Hepatorenal Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Hepatorenal Syndrome:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.2NPY, IL18, ACE, TNF
2MP:00053698.2EDN1, TNF, REN, IL18, CST3, ALB
3MP:00053817.9F2, EDN1, EDN3, TNF, IL18, ALB
4MP:00107717.9F2, EDN3, TNF, AQP2, NAGLU, IL18
5MP:00053897.8F2, TNF, AQP2, AQP1, REN, ACE
6MP:00053707.4TNF, NAGLU, ACE, ALB, NPY
7MP:00053677.1NPY, EDN1, AQP2, AQP1, NAGLU, REN
8MP:00053976.7F2, TNF, AQP2, AQP1, NAGLU, REN
9MP:00036316.6TNF, EDN3, EDN1, F2, AQP1, NAGLU
10MP:00053856.4F2, EDN1, TNF, AQP1, NAGLU, REN
11MP:00053866.4EDN3, TNF, AQP2, AQP1, NAGLU, REN
12MP:00053786.4F2, TNF, AQP2, AQP1, NAGLU, REN
13MP:00107686.2TNF, EDN3, EDN1, F2, AQP2, AQP1
14MP:00053766.0AQP1, AQP2, TNF, EDN1, F2, REN

Publications for Hepatorenal Syndrome

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Articles related to Hepatorenal Syndrome:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Nonselective I^ blockers increase risk for hepatorenal syndrome and death in patients with cirrhosis and spontaneous bacterial peritonitis. (24631577)
2014
2
Hepatorenal syndrome type 1 and bacterial infection: a catastrophic association in patients with cirrhosis. (24425447)
2014
3
Results of pretransplant treatment of hepatorenal syndrome with terlipressin. (23652609)
2013
4
Severe ischemic bowel necrosis caused by terlipressin during treatment of hepatorenal syndrome. (24459647)
2013
5
Native renal function after combined liver-kidney transplant for type 1 hepatorenal syndrome: initial report on the use of postoperative Technetium-99 m-mercaptoacetyltriglycine scans. (23384317)
2013
6
Renal and circulatory effects of large volume plasma expansion in patients with hepatorenal syndrome type 1. (22345341)
2012
7
On the role of pentoxifylline versus other TNF-alpha inhibitors in the prevention of hepatorenal syndrome. (22595802)
2012
8
Severe acute alcoholic hepatitis and hepatorenal syndrome: role of transjugular intrahepatic portosystemic stent shunt. (22802893)
2012
9
Living donor liver transplantation for hepatorenal syndrome: to do or not to do? That is the question. (22740330)
2012
10
Clinical outcomes of patients with hepatorenal syndrome after living donor liver transplantation. (22714872)
2012
11
Terlipressin in hepatorenal syndrome: a systematic review and meta-analysis. (20306131)
2011
12
Renal failure in patients with cirrhosis: hepatorenal syndrome and renal support strategies. (20124895)
2010
13
Terlipressin therapy for reversal of type 1 hepatorenal syndrome: a meta-analysis of randomized controlled trials. (20074149)
2010
14
Hepatorenal syndrome: a review. (21410072)
2010
15
Systematic review of randomized trials on vasoconstrictor drugs for hepatorenal syndrome. (19885875)
2010
16
TIPS for the treatment of refractory ascites, hepatorenal syndrome and hepatic hydrothorax: a critical update. (20581246)
2010
17
Acute kidney injury: new concepts. Hepatorenal syndrome: the role of vasopressors. (18802378)
2008
18
Long-term outcome of patients treated with terlipressin for types 1 and 2 hepatorenal syndrome. (17784863)
2008
19
Towards goal-directed therapy of hepatorenal syndrome: we have the tools but we need the trials. (18394181)
2008
20
Management of hepatorenal syndrome. (18539334)
2008
21
Hepatorenal syndrome: an update. (17505686)
2007
22
Hepatorenal syndrome. What's new in 2007?]. (17345016)
2007
23
Possible increased risk of pulmonary edema in patients with hepatorenal syndrome on adding octreotide to albumin / noradrenaline therapies. (17496406)
2007
24
Terlipressin for hepatorenal syndrome. (17054242)
2006
25
Generalized decreased osseous uptake on bone scintigraphy in hepatorenal syndrome. (16319651)
2005
26
Hepatorenal syndrome: a dreaded complication of end-stage liver disease. (15667508)
2005
27
Vasopressin, not octreotide, may be beneficial in the treatment of hepatorenal syndrome: a retrospective study. (15956066)
2005
28
Advances in therapy for ascites and hepatorenal syndrome]. (15650969)
2005
29
Hepatorenal syndrome. (15381144)
2005
30
Correlative study between angiotensin-converting enzyme gene polymorphism and hepatorenal syndrome]. (15698501)
2005
31
Anti-leukotriene drugs in the prevention and treatment of hepatorenal syndrome. (12628221)
2003
32
Terlipressin-induced vasoconstriction reversed with N-acetylcysteine: a case for combined use in hepatorenal syndrome? (12454887)
2002
33
Current management and novel therapeutic strategies for refractory ascites and hepatorenal syndrome. (11391027)
2001
34
Successful therapy of hepatorenal syndrome with norepinephrine]. (11194884)
2000
35
Reversibility of hepatorenal syndrome in an anuric patient with child C cirrhosis requiring haemodialysis for 7 weeks. (10862650)
2000
36
More therapy for hepatorenal syndrome. (10220524)
1999
37
Pathophysiology, clinical features and management of hepatorenal syndrome. (10710816)
1998
38
Fetal enterolithiasis and anhydramnios; due to in utero hepatorenal syndrome? (9854732)
1998
39
Pathophysiology and treatment of hepatorenal syndrome. (9660529)
1998
40
Hepatorenal syndrome. (18417943)
1996
41
Hepatorenal syndrome. Long-term treatment with terlipressin as a bridge to liver transplantation. (8654133)
1996
42
Tc-99m DTPA and I-131 hippurate renography. Findings in hepatorenal syndrome. (1617840)
1992
43
Urinary sodium levels related to jaundice duration in the assessment of postoperative risk of hepatorenal syndrome in elderly patients undergoing surgery for biliary obstruction. (2745041)
1989
44
Effects of lumbar sympathetic block on kidney function in cirrhotic patients with hepatorenal syndrome. (3693861)
1987
45
Pathogenesis of the hepatorenal syndrome. (2953301)
1987
46
Spontaneous ascites filtration and reinfusion (SAFR) as ambulatory chronic treatment for hepatorenal syndrome. (3837486)
1985
47
Therapeutic trial of thromboxane synthesis inhibition in the hepatorenal syndrome. (6593268)
1984
48
Hepatorenal syndrome. (7002455)
1980
49
Effects of a portacaval or peritoneovenous shunt on renin in the hepatorenal syndrome. (491398)
1979
50
CURRENT CONCEPT OF THE HEPATORENAL SYNDROME. A CLINICO-PATHOLOGIC STUDY. (14077871)
1963

Variations for Hepatorenal Syndrome

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Expression for genes affiliated with Hepatorenal Syndrome

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Expression patterns in normal tissues for genes affiliated with Hepatorenal Syndrome

Search GEO for disease gene expression data for Hepatorenal Syndrome.

Pathways for genes affiliated with Hepatorenal Syndrome

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Pathways related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.5F2, EDN1, EDN3
2
Show member pathways
9.5EDN3, EDN1, F2
39.5IL18, TNF
49.5IL18, TNF
5
Show member pathways
thioredoxin pathway37
9.4ALB, TNF, F2
69.4EDN1, TNF, NPPA
7
Show member pathways
9.4ACE, REN
89.2CST3, ACE
9
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.2EDN1, TNF, IL18
10
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.2IL18, TNF, F2
11
Show member pathways
9.0NPY, EDN3, EDN1, F2
12
Show member pathways
8.7TNF, CST3, NPPA, NPY

Compounds for genes affiliated with Hepatorenal Syndrome

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Compounds related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 230)
idCompoundScoreTop Affiliating Genes
1toki-shakuyaku-san449.9REN, NPPA, EDN1
251-cr-edta449.7CST3, NPPA, ALB, REN
3ibopamine449.3REN, ACE, NPPA
4cilazapril44 1110.2EDN1, REN, ACE, NPPA
5fosinopril44 1110.2ACE, NPPA, ALB, REN
6trandolapril44 1110.2ACE, NPPA, REN, EDN1
7omapatrilat449.2EDN1, REN, NPPA, ACE
8alacepril449.2REN, ACE, NPPA
9quinapril44 50 1111.2EDN1, ACE, REN, NPPA
10enalaprilat449.2REN, EDN1, ACE, NPPA
11valsartan44 61 28 1112.1EDN1, REN, ACE, ALB
12irbesartan44 28 50 1112.1ALB, REN, ACE, EDN1
13inulin449.1CST3, REN, NAGLU, ALB, NPPA
14desmopressin44 61 28 1112.1NPPA, F2, AQP2, NAGLU, REN
15thiorphan44 28 1111.0EDN3, EDN1, NPPA, ACE
16diltiazem44 28 50 1112.0REN, EDN1, F2, ACE
17ramipril44 119.9ALB, REN, NPPA, CST3, ACE
18hydrochlorothiazide44 28 50 24 1112.8ACE, REN, AQP2, ALB
19sodium nitroprusside448.8EDN1, EDN3, AQP1, REN, NPPA, NPY
20lisinopril44 50 24 1111.8ACE, ALB, REN, NPPA, NPY
21amlodipine44 50 24 1111.8ALB, ACE, REN, NPPA
22digoxin44 61 50 24 1112.8F2, NPPA, CST3, REN, ACE
23perindopril44 50 1110.7NAGLU, REN, ACE, NPPA, ALB
24phosphoramidon44 119.6NPPA, NPY, EDN3, EDN1, ACE
25kininogen448.6NPPA, ALB, CST3, REN, ACE, F2
26spironolactone44 61 28 50 1112.6REN, ALB, NPPA, ACE
27homocysteine44 249.6ALB, CST3, IL18, NAGLU, F2
28epinephrine44 24 1110.5F2, REN, NPPA, IL18, NPY, AQP2
29enalapril44 50 1110.4REN, NPPA, ALB, ACE, NAGLU, EDN1
30losartan44 50 28 1111.4EDN1, NAGLU, NPPA, ALB, ACE, REN
31furosemide44 61 28 50 24 1113.4ALB, ACE, NPPA, AQP2, NAGLU, REN
32pge2448.3TNF, EDN1, EDN3, AQP2, REN, IL18
33captopril44 61 50 28 1112.3EDN1, EDN3, REN, ACE, ALB, NPPA
34indomethacin44 28 61 1111.2NPY, TNF, IL18, REN, EDN3, EDN1
35methotrexate50 44 1110.2F2, TNF, NAGLU, IL18, CST3, ALB
36histamine44 28 2410.1EDN1, ALB, EDN3, TNF, NPY, IL18
37vegf447.9NPPA, CST3, TNF, IL18, EDN1, AQP1
38prostacyclin447.8NPY, NPPA, REN, TNF, EDN3, EDN1
39norepinephrine44 24 119.8REN, EDN1, NPY, ACE, IL18, EDN3
40nifedipine44 28 50 1110.8NPY, ACE, EDN3, REN, NAGLU, EDN1
41cyclosporin a44 28 619.7CST3, EDN1, NPPA, F2, TNF, AQP2
42lactate447.7F2, NPY, CST3, ALB, IL18, NAGLU
43arginine447.6NPY, AQP1, REN, AQP2, EDN3, IL18
44alanine447.3CST3, ALB, NPY, IL18, NAGLU, AQP1
45potassium44 24 119.2NPPA, CST3, ACE, REN, NAGLU, AQP1
46sodium44 247.9IL18, ACE, REN, NAGLU, AQP1, AQP2
47glucose446.5NPY, EDN3, IL18, CST3, AQP1, NAGLU
48nitric oxide44 24 118.1TNF, EDN3, EDN1, AQP2, AQP1, NAGLU
49creatinine446.1NPY, NPPA, ALB, CST3, IL18, ACE
50calcium44 50 24 119.0IL18, ALB, NPPA, EDN3, NPY, CST3

GO Terms for genes affiliated with Hepatorenal Syndrome

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Cellular components related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700627.7AQP1, NAGLU, ACE, CST3, ALB, AQP2
2extracellular spaceGO:0056155.9NPY, F2, EDN1, EDN3, TNF, REN
3extracellular regionGO:0055765.7TNF, EDN3, EDN1, F2, REN, ACE

Biological processes related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1nitric oxide transportGO:03018510.2EDN1, AQP1
2vein smooth muscle contractionGO:01482610.2EDN3, EDN1
3renal water transportGO:00309710.2AQP1, AQP2
4peptide hormone secretionGO:03007210.2EDN3, EDN1
5cellular response to mercury ionGO:07128810.2AQP2, AQP1
6regulation of systemic arterial blood pressure by endothelinGO:00310010.2EDN1, EDN3
7artery smooth muscle contractionGO:01482410.1EDN3, EDN1
8cellular response to copper ionGO:07128010.1AQP2, AQP1
9glycerol transportGO:01579310.1AQP2, AQP1
10inositol phosphate-mediated signalingGO:04801610.1EDN3, EDN1
11cGMP biosynthetic processGO:00618210.1AQP1, NPPA
12positive regulation of hormone secretionGO:04688710.1EDN3, EDN1
13cell volume homeostasisGO:00688410.1AQP2, AQP1
14positive regulation of heart rateGO:01046010.1EDN3, EDN1
15vasoconstrictionGO:04231010.0EDN3, EDN1
16response to lipopolysaccharideGO:0324969.9EDN1, AQP2, REN
17response to salt stressGO:0096519.8AQP2, TNF
18positive regulation of mitosisGO:0458409.7EDN1, EDN3, TNF
19positive regulation of nitric oxide biosynthetic processGO:0454299.7TNF, EDN1
20positive regulation of MAP kinase activityGO:0434069.7TNF, EDN3, EDN1
21angiotensin maturationGO:0020039.7ACE, REN
22cell surface receptor signaling pathwayGO:0071669.6EDN3, EDN1, F2
23middle ear morphogenesisGO:0424749.6EDN1, NAGLU
24positive regulation of NF-kappaB import into nucleusGO:0423469.6IL18, TNF
25response to hypoxiaGO:0016669.6EDN1, TNF, NPPA
26lipopolysaccharide-mediated signaling pathwayGO:0316639.4IL18, TNF
27regulation of vasoconstrictionGO:0192299.4ACE, EDN3, EDN1
28positive regulation of JUN kinase activityGO:0435079.4TNF, EDN1
29regulation of blood pressureGO:0082179.0NPY, NPPA, ACE, REN

Molecular functions related to Hepatorenal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycerol transmembrane transporter activityGO:0151689.8AQP1, AQP2
2water transmembrane transporter activityGO:0053729.7AQP2, AQP1
3hormone activityGO:0051799.3NPPA, EDN3, EDN1
4cytokine activityGO:0051259.2IL18, TNF, EDN1
5receptor bindingGO:0051028.8NPY, NPPA, REN, EDN3, F2

Products for genes affiliated with Hepatorenal Syndrome

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Sources for Hepatorenal Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet