MCID: HPT070
MIFTS: 24

Hepatosplenic T-Cell Lymphoma malady

Cancer, Blood, Immune, Liver categories

Summaries for Hepatosplenic T-Cell Lymphoma

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33MalaCards
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MalaCards: Hepatosplenic T-Cell Lymphoma is related to t-cell leukemia and systemic lupus erythematosus. An important gene associated with Hepatosplenic T-Cell Lymphoma is DPP4 (dipeptidyl-peptidase 4), and among its related pathways is Hematopoietic cell lineage. The compounds atorvastatin and rosiglitazone have been mentioned in the context of this disorder. Affiliated tissues include t cells.

Aliases & Classifications for Hepatosplenic T-Cell Lymphoma

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune, Liver


Characteristics (Orphanet epidemiological data):

49
hepatosplenic t-cell lymphoma:
Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

hepatosplenic t-cell lymphoma 49 61


External Ids:

ICD10 via Orphanet26 C84.4
SNOMED-CT via Orphanet58 445406001
UMLS via Orphanet62 C1333984
ICD1025 C86.1

Related Diseases for Hepatosplenic T-Cell Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Hepatosplenic T-Cell Lymphoma:



Diseases related to hepatosplenic t-cell lymphoma

Clinical Features for Hepatosplenic T-Cell Lymphoma

Drugs & Therapeutics for Hepatosplenic T-Cell Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hepatosplenic T-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Hepatosplenic T-Cell Lymphoma

Search NIH Clinical Center for Hepatosplenic T-Cell Lymphoma

Search CenterWatch for Hepatosplenic T-Cell Lymphoma

Genetic Tests for Hepatosplenic T-Cell Lymphoma

Anatomical Context for Hepatosplenic T-Cell Lymphoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Hepatosplenic T-Cell Lymphoma:

33
T cells

Animal Models for Hepatosplenic T-Cell Lymphoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Hepatosplenic T-Cell Lymphoma

Sources:
51PubMed
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Articles related to Hepatosplenic T-Cell Lymphoma:

(show all 26)
idTitleAuthorsYear
1
Successful treatment of hepatosplenic T-cell lymphoma with ESHAP followed by autologous stem cell transplant. (23598914)
2013
2
Intensive induction chemotherapy followed by early high-dose therapy and hematopoietic stem cell transplantation results in improved outcome for patients with hepatosplenic T-cell lymphoma: a single institution experience. (23107915)
2013
3
Histopathological, immunophenotypic and clinical particularities and evolution of a case of hepatosplenic T-cell lymphoma in transformation to leukemia. (24399013)
2013
4
The incidence of hepatosplenic T-cell lymphoma in a large managed care organization, with reference to anti-tumor necrosis factor therapy, Northern California, 2000-2006. (21823196)
2012
5
Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets. (22510872)
2012
6
F-18 flourodeoxyglucose positron emission tomography/computed tomography findings in a case of hepatosplenic T-cell lymphoma. (22531524)
2012
7
Hepatosplenic T-cell lymphoma in patients receiving TNF-I+ inhibitor therapy: expanding the groups at risk. (21941193)
2011
8
Hepatosplenic T cell lymphoma responsive to 2'-deoxycoformycin therapy. (20652973)
2010
9
Hepatosplenic T-cell lymphoma in inflammatory bowel disease: a possible thiopurine-induced chromosomal abnormality. (20927075)
2010
10
Crohn's disease, hepatosplenic T-cell lymphoma and no biological therapy: are we barking up the wrong tree? (19067412)
2009
11
Sustained first remission in an adolescent with hepatosplenic T-cell lymphoma treated with T-cell leukemia induction, nucleoside analog-based consolidation, and early hematopoietic stem cell transplant. (19479793)
2009
12
Importance of early splenectomy in patients with hepatosplenic T-cell lymphoma and severe thrombocytopenia. (19408055)
2009
13
Hepatosplenic T-cell lymphoma following infliximab therapy for Crohn's disease. (19296822)
2009
14
Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease: update. (19274799)
2009
15
Post-transplant hepatosplenic T-cell lymphoma successfully treated with HyperCVAD regimen. (17876769)
2008
16
Hepatosplenic T-cell lymphoma following infliximab therapy for Crohn's disease. (18928444)
2008
17
Long-term survival in two patients with hepatosplenic T cell lymphoma treated with interferon-alpha. (18452073)
2008
18
Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. (17255842)
2007
19
Hepatosplenic T-cell lymphoma in a patient with Crohn's disease who received infliximab therapy. (17613771)
2007
20
Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: a cautionary tale? (17480018)
2007
21
Gamma-delta hepatosplenic T-cell lymphoma. Description of a case with immunophenotypic and molecular follow-up successfully treated with chemotherapy alone. (16321867)
2006
22
Hepatosplenic T-cell lymphoma in an adolescent patient after immunomodulator and biologic therapy for Crohn disease. (15699701)
2005
23
Hepatosplenic T-cell lymphoma of alphabeta lineage in a 16-year-old boy presenting with hemolytic anemia and thrombocytopenia. (10716161)
2000
24
Hepatosplenic gamma-delta T-cell lymphoma as a late-onset posttransplant lymphoproliferative disorder in renal transplant recipients. (10761449)
2000
25
Hepatosplenic T-cell lymphoma: prolymphocytic transformation 18 months after splenectomy. (9277054)
1997
26
Hepatosplenic T-cell lymphoma: an unusual case of a gamma delta T-cell lymphoma with a blast-like terminal transformation. (8314255)
1994

Genetic Variations for Hepatosplenic T-Cell Lymphoma

Expression for genes affiliated with Hepatosplenic T-Cell Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatosplenic T-Cell Lymphoma

Search GEO for disease gene expression data for Hepatosplenic T-Cell Lymphoma.

Pathways for genes affiliated with Hepatosplenic T-Cell Lymphoma

Sources:
30KEGG
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Pathways related to Hepatosplenic T-Cell Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CD7, TNF

Compounds for genes affiliated with Hepatosplenic T-Cell Lymphoma

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Hepatosplenic T-Cell Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1atorvastatin45 50 29 11 2413.1TNF, DPP4
2rosiglitazone45 50 29 11 2413.0DPP4, TNF
3butyrate459.0DPP4, TNF
4methotrexate45 50 1110.9TNF, DPP4
5rantes458.7DPP4, TNF

GO Terms for genes affiliated with Hepatosplenic T-Cell Lymphoma

Sources:
16Gene Ontology
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Cellular components related to Hepatosplenic T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.0DPP4, TNF

Biological processes related to Hepatosplenic T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:0016669.0DPP4, TNF
2T cell activationGO:0421109.0CD7, DPP4

Molecular functions related to Hepatosplenic T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.0DPP4, TNF

Products for genes affiliated with Hepatosplenic T-Cell Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatosplenic T-Cell Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet