BRCA1
MCID: HRD004
MIFTS: 45

Hereditary Breast Ovarian Cancer (BRCA1) malady

Genetic diseases, Cancer diseases, Reproductive diseases, Rare diseases categories
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Summaries for Hereditary Breast Ovarian Cancer

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MalaCards based summary: Hereditary Breast Ovarian Cancer, also known as familial breast and ovarian cancer syndrome, is related to ovarian cancer and breast cancer. An important gene associated with Hereditary Breast Ovarian Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Prostate cancer and Integrated Breast Cancer Pathway. The compounds 17beta-hydroxysteroid and 8-oxoguanine have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and heart, and related mouse phenotypes are behavior/neurological and embryogenesis.

Descriptions from OMIM:46 612555,604370

Aliases & Classifications for Hereditary Breast Ovarian Cancer

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Hereditary Breast Ovarian Cancer, Aliases & Descriptions:

Name: Hereditary Breast Ovarian Cancer 8 10
Familial Breast and Ovarian Cancer Syndrome 8
 
Brca2 8
Brca1 8


Classifications:



External Ids:

Disease Ontology8 DOID:5683
NCIt39 C8493

Related Diseases for Hereditary Breast Ovarian Cancer

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Diseases in the Breast-Ovarian Cancer, Familial, 1 family:

hereditary breast ovarian cancer Rad51c-Related Familial Susceptibility to Breast-Ovarian Cancer
Rad51d-Related Familial Susceptibility to Breast-Ovarian Cancer Breast-Ovarian Cancer, Familial, 2
Breast-Ovarian Cancer, Familial 4 Breast-Ovarian Cancer, Familial 3

Diseases related to Hereditary Breast Ovarian Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian cancer31.5BRCA1, BRCA2
2breast cancer31.4HSD17B2, BRCA2, BRCA1
3male breast cancer30.7BRCA2, BRCA1
4bilateral breast cancer30.6BRCA2, BRCA1
5brca1 and brca2 hereditary breast and ovarian cancer30.6BRCA2, BRCA1
6breast-ovarian cancer, familial, 130.6BRCA2, HSD17B2
7fallopian tube cancer30.5BRCA2, BRCA1
8peritoneal carcinoma30.4BRCA1, BRCA2
9fanconi's anemia30.4BRCA1, BRCA2
10ataxia telangiectasia30.4BRCA2, BRCA1
11li-fraumeni syndrome30.3BRCA2, BRCA1
12cowden disease30.3BRCA2, BRCA1
13ductal carcinoma in situ30.3BRCA1, BRCA2
14lynch syndrome30.1BRCA1, BRCA2
15dysgerminoma30.0BRCA1, BRCA2
16gynecomastia30.0BRCA1, BRCA2
17bloom syndrome30.0BRCA2, BRCA1
18familial colorectal cancer29.8BRCA1, BRCA2
19endometrial carcinoma29.5BRCA2, BRCA1
20retinoblastoma29.4BRCA2, BRCA1
21sporadic breast cancer10.8
22breast cancer susceptibility10.8
23familial breast cancer10.8
24prostate cancer10.7
25prostatitis10.7
26breast cancer, invasive ductal10.6
27breast cancer, lobular10.6
28breast cancer, protection against10.6
29breast cancer, early-onset10.6
30lung cancer10.5
31fanconi anemia, complementation group d110.5
32ataxia10.3
33cystadenoma10.3
34gastric cancer10.3
35ovarian cystadenoma10.3
36ovarian cancer, somatic10.3
37breast cancer, somatic10.3
38ocular melanoma10.3
39breast-ovarian cancer, familial, 210.3
40peritonitis10.2
41mutagen sensitivity10.2
42hypoxia10.2
43pancreatic cancer 410.2
44medulloblastoma10.2
45glioblastoma 310.2
46colorectal cancer10.2
47huntington's disease10.2
48pancreatic cancer10.2
49papillary serous adenocarcinoma10.2
50adenocarcinoma10.2

Graphical network of the top 20 diseases related to Hereditary Breast Ovarian Cancer:



Diseases related to hereditary breast ovarian cancer

Symptoms for Hereditary Breast Ovarian Cancer

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Clinical features from OMIM:

612555,604370

Drugs & Therapeutics for Hereditary Breast Ovarian Cancer

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Drug clinical trials:

Search ClinicalTrials for Hereditary Breast Ovarian Cancer

Search NIH Clinical Center for Hereditary Breast Ovarian Cancer

Genetic Tests for Hereditary Breast Ovarian Cancer

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Anatomical Context for Hereditary Breast Ovarian Cancer

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MalaCards organs/tissues related to Hereditary Breast Ovarian Cancer:

32
Breast, Testes, Heart, Ovary

Animal Models for Hereditary Breast Ovarian Cancer or affiliated genes

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MGI Mouse Phenotypes related to Hereditary Breast Ovarian Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.5BRCA1, BRCA2, HSD17B2
2MP:00053808.2BRCA1, BRCA2, HSD17B2

Publications for Hereditary Breast Ovarian Cancer

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Articles related to Hereditary Breast Ovarian Cancer:

(show top 50)    (show all 65)
idTitleAuthorsYear
1
Genetic counseling does not fulfill the counselees' need for certainty in hereditary breast/ovarian cancer families: an explorative assessment. (22777929)
2013
2
Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases. (23935836)
2013
3
Hereditary breast/ovarian cancer syndrome: a primer for obstetricians/gynecologists. (24021253)
2013
4
Unpacking the blockers: understanding perceptions and social constraints of health communication in hereditary breast ovarian cancer (HBOC) susceptibility families. (21547418)
2011
5
Comprehensive genetic characterization of hereditary breast/ovarian cancer families from Slovakia. (21203900)
2011
6
Hereditary breast-ovarian cancer syndrome in Russia. (22649661)
2010
7
Coronary heart disease risk profile in women who underwent salpingo-oophorectomy to prevent hereditary breast ovarian cancer. (20169665)
2010
8
Hereditary breast ovarian cancer syndromes in the Maritimes. (20181317)
2010
9
Founder BRCA1/2 mutations in the Europe: implications for hereditary breast-ovarian cancer prevention and control. (23199084)
2010
10
Metabolic syndrome after risk-reducing salpingo-oophorectomy in women at high risk for hereditary breast ovarian cancer: a controlled observational study. (19008092)
2009
11
The prevalence of hereditary breast/ovarian cancer risk in patients with a history of breast or ovarian cancer in Japanese subjects. (20149041)
2009
12
Brief assessment of parents' attitudes toward testing minor children for hereditary breast/ovarian cancer genes: development and validation of the Pediatric BRCA1/2 Testing Attitudes Scale (P-TAS). (18385162)
2009
13
A controlled study of mental distress and somatic complaints after risk-reducing salpingo-oophorectomy in women at risk for hereditary breast ovarian cancer. (19178933)
2009
14
Fatigue and quality of life after risk-reducing salpingo-oophorectomy in women at increased risk for hereditary breast-ovarian cancer. (19820364)
2009
15
Founder mutations account for the majority of BRCA1-attributable hereditary breast/ovarian cancer cases in a population from Tuscany, Central Italy. (18821011)
2009
16
BRCA1 and BRCA2 risk perceptions among African American women at increased risk for hereditary breast-ovarian cancer. (18417966)
2008
17
Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer. (19016756)
2008
18
Hereditary breast/ovarian cancer: clinicopathological characteristics and survival of BRCA2 positive and negative cases. (19066131)
2008
19
Psychological and cancer-specific distress at 18 months post-testing in women with demonstrated BRCA1 mutations for hereditary breast/ovarian cancer. (18219587)
2008
20
Hereditary breast-ovarian cancer: clinical findings and medical management. (17901820)
2007
21
A novel BRCA1 mutation in an Indian family with hereditary breast/ovarian cancer. (17131039)
2007
22
Patient responses to the disclosure of BRCA mutation tests in hereditary breast-ovarian cancer families. (16527602)
2006
23
Germline mutations of BRCA1 in two Korean hereditary breast/ovarian cancer families. (16465413)
2006
24
Low rates of acceptance of BRCA1 and BRCA2 test results among African American women at increased risk for hereditary breast-ovarian cancer. (16980814)
2006
25
Clinical, molecular and geographical features of hereditary breast/ovarian cancer in latvia. (20223033)
2005
26
Hereditary Breast-Ovarian Cancer Team of the University Medical Centre Groningen (UMCG) - a Report. (20223045)
2005
27
Re: "Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations". (16188301)
2005
28
Surveillance behavior and prophylactic surgery after predictive testing for hereditary breast/ovarian cancer. (16252621)
2005
29
The effect of experiential knowledge on construction of risk perception in hereditary breast/ovarian cancer. (15789156)
2005
30
Prevalence of five previously reported and recurrent BRCA1 genetic rearrangement mutations in 20,000 patients from hereditary breast/ovarian cancer families. (15846789)
2005
31
Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations. (15863145)
2005
32
Advocate's Viewpoint on Hereditary Breast/Ovarian Cancer. (20233464)
2004
33
Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer. (12920070)
2003
34
Hereditary breast-ovarian cancer at the bedside: role of the medical oncologist. (12586815)
2003
35
Contribution of BRCA2 germline mutations to hereditary breast/ovarian cancer in Germany. (11897832)
2002
36
Genetic counseling in hereditary breast/ovarian cancer in Israel: psychosocial impact and retention of genetic information. (12210341)
2002
37
Hereditary breast/ovarian cancer--pitfalls in genetic counseling. (11683778)
2001
38
Men at risk of being a mutation carrier for hereditary breast/ovarian cancer: an exploration of attitudes and psychological functioning during genetic testing. (11464240)
2001
39
Histology of prophylactically removed ovaries from BRCA1 and BRCA2 mutation carriers compared with noncarriers in hereditary breast ovarian cancer syndrome kindreds. (10985881)
2000
40
Physicians' attitudes towards mammography and prophylactic surgery for hereditary breast/ovarian cancer risk and subsequently published guidelines. (10780786)
2000
41
Congress report of the Sixth International Meeting on Psychosocial Aspects of Hereditary Breast/Ovarian Cancer Genetic Testing. (11180590)
2000
42
Attitudes toward prophylactic oophorectomy and screening utilization in women at increased risk of developing hereditary breast/ovarian cancer. (10502438)
1999
43
Acceptable strategies for dealing with hereditary breast/ovarian cancer risk. (9168189)
1997
44
German family study on hereditary breast-ovarian cancer. (8863152)
1996
45
BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes. (8648868)
1996
46
Insurance adjudication favoring prophylactic surgery in hereditary breast-ovarian cancer syndrome. (7705697)
1995
47
Splice-site mutation of the p53 gene in a family with hereditary breast-ovarian cancer. (8302608)
1994
48
The human insulin-like growth factor-binding protein 4 gene maps to chromosome region 17q12-q21.1 and is close to the gene for hereditary breast-ovarian cancer. (7507078)
1993
49
Hereditary breast-ovarian cancer: how can we use the new DNA markers to improve patient management? (8306541)
1993
50
Genetic counselling and hereditary breast ovarian cancer. (1349410)
1992

Variations for Hereditary Breast Ovarian Cancer

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Expression for genes affiliated with Hereditary Breast Ovarian Cancer

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Expression patterns in normal tissues for genes affiliated with Hereditary Breast Ovarian Cancer

Search GEO for disease gene expression data for Hereditary Breast Ovarian Cancer.

Pathways for genes affiliated with Hereditary Breast Ovarian Cancer

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Pathways related to Hereditary Breast Ovarian Cancer according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.3BRCA1, HSD17B2
29.0BRCA1, BRCA2
3
Show member pathways
9.0BRCA2, BRCA1
4
Show member pathways
Signaling Pathways in Glioblastoma37
9.0BRCA1, BRCA2
5
Show member pathways
9.0BRCA1, BRCA2
69.0BRCA1, BRCA2
7
Show member pathways
9.0BRCA1, BRCA2
8
Show member pathways
9.0BRCA2, BRCA1
9
Show member pathways
9.0BRCA1, BRCA2
109.0BRCA1, BRCA2
119.0BRCA2, BRCA1
12
Show member pathways
9.0BRCA1, BRCA2
13
Show member pathways
9.0BRCA1, BRCA2

Compounds for genes affiliated with Hereditary Breast Ovarian Cancer

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Compounds related to Hereditary Breast Ovarian Cancer according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
117beta-hydroxysteroid449.7BRCA1, HSD17B2
28-oxoguanine449.4BRCA2, BRCA1
3daidzein449.4BRCA2, BRCA1
4lycopene44 2410.4BRCA1, BRCA2
5indole-3-carbinol449.4BRCA1, BRCA2
6methylmethanesulfonate449.4BRCA1, BRCA2
74-hydroxytamoxifen449.4BRCA2, BRCA1
8bleomycin44 1110.4BRCA1, BRCA2
9adpribose449.4BRCA1, BRCA2
10hydroxyurea44 50 1111.4BRCA1, BRCA2
11mitomycin c449.4BRCA2, BRCA1
12p003449.4BRCA1, BRCA2
13vincristine44 50 1111.3BRCA1, BRCA2
14p002449.3BRCA2, BRCA1
15resveratrol44 61 24 1112.3BRCA1, BRCA2
16adriamycin449.3BRCA2, BRCA1
17gold449.3BRCA1, BRCA2
18camptothecin44 61 1111.3BRCA1, BRCA2
19docetaxel44 50 61 1112.3BRCA1, BRCA2
20folate449.3BRCA2, BRCA1
21methotrexate50 44 1111.2BRCA1, BRCA2
22polyacrylamide449.2BRCA1, BRCA2
23etoposide44 50 61 1112.2BRCA2, BRCA1
24tamoxifen44 50 28 1112.1BRCA1, BRCA2
25paclitaxel44 50 1111.1BRCA2, BRCA1
26paraffin449.0BRCA1, BRCA2
27glutamine449.0BRCA1, BRCA2
28genistein44 28 61 2 24 1113.9BRCA1, BRCA2
29estradiol44 24 1110.9BRCA1, BRCA2, HSD17B2
30progesterone44 28 61 24 1112.9HSD17B2, BRCA2, BRCA1
31testosterone44 61 24 1111.9BRCA1, BRCA2, HSD17B2
32steroid448.9HSD17B2, BRCA2, BRCA1
33estrogen448.9BRCA1, BRCA2, HSD17B2
34retinoic acid44 249.9HSD17B2, BRCA2, BRCA1
35proline448.7BRCA1, BRCA2

GO Terms for genes affiliated with Hereditary Breast Ovarian Cancer

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Cellular components related to Hereditary Breast Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.0BRCA1, BRCA2

Biological processes related to Hereditary Breast Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.0BRCA1, BRCA2
2DNA repairGO:0062819.0BRCA1, BRCA2
3double-strand break repair via homologous recombinationGO:0007248.9BRCA1, BRCA2
4double-strand break repairGO:0063028.7BRCA1, BRCA2

Products for genes affiliated with Hereditary Breast Ovarian Cancer

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Sources for Hereditary Breast Ovarian Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet