CAA
MCID: HRD084
MIFTS: 25

Hereditary Cerebral Amyloid Angiopathy (CAA) malady

Genetic diseases category

Summaries for Hereditary Cerebral Amyloid Angiopathy

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21Genetics Home Reference, 32MalaCards
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Genetics Home Reference:21 Hereditary cerebral amyloid angiopathy is a condition that can cause a progressive loss of intellectual function (dementia), stroke, and other neurological problems starting in mid-adulthood. Due to neurological decline, this condition is typically fatal in one's sixties, although there is variation depending on the severity of the signs and symptoms. Most affected individuals die within a decade after signs and symptoms first appear, although some people with the disease have survived longer.

MalaCards: Hereditary Cerebral Amyloid Angiopathy, also known as autosomal dominant cerebrovascular amyloidosis, is related to cerebral amyloid angiopathy and amyloidosis. An important gene associated with Hereditary Cerebral Amyloid Angiopathy is APP (amyloid beta (A4) precursor protein), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Neuroscience. The compounds thioflavine s and metrifonate have been mentioned in the context of this disorder. Related mouse phenotype other.

Aliases & Classifications for Hereditary Cerebral Amyloid Angiopathy

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21Genetics Home Reference, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases


Aliases & Descriptions:

hereditary cerebral amyloid angiopathy 21 44
autosomal dominant cerebrovascular amyloidosis 21
cerebral amyloid angiopathy, hereditary 60
cerebral amyloid angiopathy, familial 21
cerebral amyloid angiopathy, genetic 21
cerebral amyloid angiopathy familial 44
hchwa 21
caa 21


Related Diseases for Hereditary Cerebral Amyloid Angiopathy

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17GeneCards, 18GeneDecks
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Diseases related to Hereditary Cerebral Amyloid Angiopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral amyloid angiopathy31.1APOE, APP
2amyloidosis30.4APP, APOE
3cerebritis10.7
4dementia10.3
5schizophrenia10.3
6congenital aural atresia10.3
7hereditary cerebral hemorrhage with amyloidosis10.2
8spinocerebellar ataxia10.1
9lysinuric protein intolerance10.1
10thalassemia10.0
11catecholaminergic polymorphic ventricular tachycardia10.0
12spinocerebellar ataxia type 1710.0
13cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.0
14cerebral degeneration10.0
15lewy body dementia10.0APOE
16vascular dementia10.0APOE
17hyperhomocysteinemia10.0APOE
18hypercholesterolemia10.0APOE
19coronary heart disease10.0APOE
20inclusion body myositis10.0APP
21age related macular degeneration10.0APOE
22myositis10.0APP
23binswanger's disease10.0APP, APOE
24stroke, hemorrhagic10.0APP, APOE
25alzheimer disease type 210.0APP, APOE
26hemorrhage, intracerebral10.0APP, APOE
27progressive supranuclear palsy10.0APOE, APP
28creutzfeldt-jakob syndrome10.0APOE, APP
29amyloid tumor10.0APOE, APP
30memory impairment10.0APP, APOE
31pick's disease10.0APOE, APP
32prion disease10.0APOE, APP
33encephalitis10.0APP
34frontotemporal dementia10.0APOE, APP
35cerebrovascular disease10.0APOE, APP
36parkinson's disease10.0APOE, APP
37urethritis9.9
38coronary aneurysm9.9
39palindromic rheumatism9.9
40timothy syndrome9.9
41alpha thalassemia9.9
42hereditary spastic paraplegia9.9
43neuronitis9.9
44neonatal diabetes mellitus9.9
45alzheimer's disease9.9
46acute myocardial infarction9.9
47bipolar disorder9.9
48diabetes mellitus9.9
49dilated cardiomyopathy9.9
50liposarcoma9.9

Graphical network of the top 20 diseases related to Hereditary Cerebral Amyloid Angiopathy:



Diseases related to hereditary cerebral amyloid angiopathy

Clinical Features for Hereditary Cerebral Amyloid Angiopathy

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Drugs & Therapeutics for Hereditary Cerebral Amyloid Angiopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hereditary Cerebral Amyloid Angiopathy

Drug clinical trials:

Search ClinicalTrials for Hereditary Cerebral Amyloid Angiopathy

Search NIH Clinical Center for Hereditary Cerebral Amyloid Angiopathy

Search CenterWatch for Hereditary Cerebral Amyloid Angiopathy

Genetic Tests for Hereditary Cerebral Amyloid Angiopathy

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Anatomical Context for Hereditary Cerebral Amyloid Angiopathy

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Animal Models for Hereditary Cerebral Amyloid Angiopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hereditary Cerebral Amyloid Angiopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1APOE, APP

Publications for Hereditary Cerebral Amyloid Angiopathy

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Genetic Variations for Hereditary Cerebral Amyloid Angiopathy

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Expression for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

Search GEO for disease gene expression data for Hereditary Cerebral Amyloid Angiopathy.

Pathways for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems
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Pathways related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1APOE, APP
29.1APOE, APP
39.1APP, APOE
49.1APOE, APP
59.1APOE, APP

Compounds for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1thioflavine s449.5APOE, APP
2metrifonate449.5APOE, APP
324s-hydroxy-cholesterol449.5APOE, APP
4thioflavin t449.5APP, APOE
5tacrine44 1110.5APOE, APP
6donepezil44 11 2411.5APOE, APP
7galantamine44 49 1111.5APOE, APP
8formate449.5APP, APOE
9ibuprofen44 28 49 11 2413.5APOE, APP
104-hydroxynonenal44 2410.5APOE, APP
11chloroquine44 2 49 28 1113.5APOE, APP
12lactacystin449.5APP, APOE
13lovastatin44 49 59 28 1113.4APOE, APP
14sodium dodecylsulfate449.4APOE, APP
15simvastatin44 49 59 28 11 2414.4APP, APOE
16folate449.4APOE, APP
17nicotine44 49 28 1112.4APOE, APP
18valine449.4APOE, APP
19vitamin a44 11 2411.4APP, APOE
20aspirin44 49 28 2412.4APOE, APP
21nmda44 2810.3APOE, APP
22acetylcholine44 49 28 11 2413.3APP, APOE
23actinomycin d449.3APOE, APP
24cyclosporin a44 28 5911.2APOE, APP
25glutamine449.2APOE, APP
26dopamine44 28 11 2412.1APP, APOE
27heparin44 28 11 2412.1APOE, APP
28creatinine449.0APOE, APP
29aspartate448.8APOE, APP

GO Terms for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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16Gene Ontology
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Biological processes related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol metabolic processGO:0082039.1APOE, APP

Molecular functions related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1APOE, APP
2heparin bindingGO:0082018.8APOE, APP

Products for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hereditary Cerebral Amyloid Angiopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet