MCID: HRD084
MIFTS: 28

Hereditary Cerebral Amyloid Angiopathy malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Neuronal diseases, Bone diseases categories

Summaries for Hereditary Cerebral Amyloid Angiopathy

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Genetics Home Reference:21 Hereditary cerebral amyloid angiopathy is a condition that can cause a progressive loss of intellectual function (dementia), stroke, and other neurological problems starting in mid-adulthood. Due to neurological decline, this condition is typically fatal in one's sixties, although there is variation depending on the severity of the signs and symptoms. Most affected individuals die within a decade after signs and symptoms first appear, although some people with the disease have survived longer.

MalaCards based summary: Hereditary Cerebral Amyloid Angiopathy, also known as autosomal dominant cerebrovascular amyloidosis, is related to cerebral amyloid angiopathy and amyloidosis. An important gene associated with Hereditary Cerebral Amyloid Angiopathy is APP (amyloid beta (A4) precursor protein), and among its related pathways are Neuroscience and Alzheimer's disease. The compounds thioflavine s and metrifonate have been mentioned in the context of this disorder. Related mouse phenotype other.

Aliases & Classifications for Hereditary Cerebral Amyloid Angiopathy

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Hereditary Cerebral Amyloid Angiopathy, Aliases & Descriptions:

Name: Hereditary Cerebral Amyloid Angiopathy 21 43
Autosomal Dominant Cerebrovascular Amyloidosis 21
Cerebral Amyloid Angiopathy, Hereditary 60
Cerebral Amyloid Angiopathy, Familial 21
Cerebral Amyloid Angiopathy, Genetic 21
 
Cerebral Amyloid Angiopathy Familial 43
Familial Cerebral Amyloid Angiopathy 60
Hchwa 21
Caa 21


Classifications:



Related Diseases for Hereditary Cerebral Amyloid Angiopathy

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Diseases in the Cerebral Amyloid Angiopathy family:

hereditary cerebral amyloid angiopathy

Diseases related to Hereditary Cerebral Amyloid Angiopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral amyloid angiopathy31.3APP, APOE
2amyloidosis30.4APP, APOE
3dementia30.3APOE, APP
4cerebritis10.8
5cerebral hemorrhage10.5
6schizophrenia10.3
7aural atresia, congenital10.3
8endotheliitis10.3
9inclusion body myositis10.2APP
10lysinuric protein intolerance10.2
11spinocerebellar ataxia10.2
12ataxia10.2
13cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.1
14thalassemia10.1
15catecholaminergic polymorphic ventricular tachycardia10.1
16amyotrophic lateral sclerosis 110.1APP
17binswanger's disease10.0APOE, APP
18hereditary cerebral hemorrhage with amyloidosis, flemish type10.0
19hereditary cerebral hemorrhage with amyloidosis, italian type10.0
20hereditary cerebral hemorrhage with amyloidosis, arctic type10.0
21hereditary cerebral hemorrhage with amyloidosis, iowa type10.0
22hereditary cerebral hemorrhage with amyloidosis, piedmont type10.0
23alzheimer disease-210.0APP, APOE
24hemorrhage, intracerebral10.0APOE, APP
25supranuclear palsy, progressive10.0APOE, APP
26dementia, lewy body10.0APOE, APP
27vascular dementia10.0APOE, APP
28creutzfeldt-jakob disease10.0APP, APOE
29pick disease10.0APOE, APP
30cerebrovascular disease10.0APOE, APP
31timothy syndrome10.0
32pancreatic cancer10.0
33myocardial infarction10.0
34acute myocardial infarction10.0
35bipolar disorder10.0
36dilated cardiomyopathy10.0
37hereditary spastic paraplegia10.0
38urethritis10.0
39palindromic rheumatism10.0
40neuronitis10.0
41neonatal diabetes mellitus10.0
42liposarcoma10.0
43pancreatitis10.0
44paraplegia10.0
45urethral obstruction10.0
46vasculitis10.0
47sickle cell disease10.0
48amyloidosis cerebral10.0
49coronary artery aneurysm10.0
50familial dilated cardiomyopathy10.0

Graphical network of the top 20 diseases related to Hereditary Cerebral Amyloid Angiopathy:



Diseases related to hereditary cerebral amyloid angiopathy

Symptoms for Hereditary Cerebral Amyloid Angiopathy

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Drugs & Therapeutics for Hereditary Cerebral Amyloid Angiopathy

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Drug clinical trials:

Search ClinicalTrials for Hereditary Cerebral Amyloid Angiopathy

Search NIH Clinical Center for Hereditary Cerebral Amyloid Angiopathy

Genetic Tests for Hereditary Cerebral Amyloid Angiopathy

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Anatomical Context for Hereditary Cerebral Amyloid Angiopathy

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Animal Models for Hereditary Cerebral Amyloid Angiopathy or affiliated genes

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MGI Mouse Phenotypes related to Hereditary Cerebral Amyloid Angiopathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1APP, APOE

Publications for Hereditary Cerebral Amyloid Angiopathy

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Articles related to Hereditary Cerebral Amyloid Angiopathy:

idTitleAuthorsYear
1
Vascular changes in Iowa-type hereditary cerebral amyloid angiopathy. (12480757)
2002
2
From gene to disease; amyloid-beta precursor protein gene instrumental in hereditary cerebral amyloid angiopathies]. (11552366)
2001
3
Dutch hereditary cerebral amyloid angiopathy: structural lesions and apolipoprotein E genotype. (9153536)
1997
4
No protective effect of apolipoprotein E epsilon 2 allele in Dutch hereditary cerebral amyloid angiopathy. (7847872)
1995
5
Progressive dementia, without cerebral hemorrhage, in a patient with hereditary cerebral amyloid angiopathy. (1335860)
1992
6
Comparison between the Icelandic and Dutch forms of hereditary cerebral amyloid angiopathy. (1320529)
1992
7
Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Research-Group Hereditary Cerebral Amyloid-Angiopathy. (2555088)
1989
8
Hereditary cerebral amyloid angiopathy: the amyloid fibrils contain a protein which is a variant of cystatin C, an inhibitor of lysosomal cysteine proteases. (3707586)
1986

Variations for Hereditary Cerebral Amyloid Angiopathy

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Expression for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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Search GEO for disease gene expression data for Hereditary Cerebral Amyloid Angiopathy.

Pathways for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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Pathways related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1APP, APOE
2
Show member pathways
Alzheimers Disease36
9.1APP, APOE
39.1APOE, APP
49.1APP, APOE
59.1APP, APOE

Compounds for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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Compounds related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards Suite gene sharing:

(show all 32)
idCompoundScoreTop Affiliating Genes
1thioflavine s439.5APP, APOE
2metrifonate439.5APP, APOE
324s-hydroxy-cholesterol439.5APP, APOE
4thioflavin t439.5APP, APOE
5tacrine43 1210.5APOE, APP
6donepezil43 49 24 1212.5APP, APOE
7galantamine43 49 1211.5APP, APOE
8formate439.5APP, APOE
9ibuprofen43 28 49 24 1213.5APOE, APP
104-hydroxynonenal43 2410.5APP, APOE
11chloroquine43 2 49 28 1213.5APP, APOE
12lactacystin439.5APP, APOE
13lovastatin43 49 59 28 1213.5APOE, APP
14sodium dodecylsulfate439.5APP, APOE
15simvastatin43 49 59 28 24 1214.5APP, APOE
16folate439.4APP, APOE
17nicotine43 28 49 1212.4APOE, APP
18valine439.4APP, APOE
19vitamin a43 24 1211.4APP, APOE
20aspirin43 49 28 2412.4APP, APOE
21nmda43 2810.4APOE, APP
22acetylcholine43 49 28 24 1213.4APP, APOE
23actinomycin d439.4APP, APOE
24cyclosporin a43 28 5911.3APP, APOE
25glutamine439.3APOE, APP
26dopamine43 28 24 1212.3APP, APOE
27creatinine439.2APP, APOE
28aspartate439.2APP, APOE
29heparin43 28 24 1212.1APOE, APP
30cholesterol43 28 24 1212.1APP, APOE
31h2o2439.0APP, APOE
32testosterone43 59 24 1211.8APP, APOE

GO Terms for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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Cellular components related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00057949.1APP, APOE

Biological processes related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cholesterol metabolic processGO:00082039.1APP, APOE

Molecular functions related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428029.1APP, APOE
2heparin bindingGO:00082018.8APP, APOE

Products for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hereditary Cerebral Amyloid Angiopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet