CAA
MCID: HRD084
MIFTS: 32

Hereditary Cerebral Amyloid Angiopathy (CAA) malady

Genetic diseases, Cardiovascular diseases, Neuronal diseases, Bone diseases, Rare diseases categories
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Summaries for Hereditary Cerebral Amyloid Angiopathy

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21Genetics Home Reference, 33MalaCards
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Genetics Home Reference:21 Hereditary cerebral amyloid angiopathy is a condition that can cause a progressive loss of intellectual function (dementia), stroke, and other neurological problems starting in mid-adulthood. Due to neurological decline, this condition is typically fatal in one's sixties, although there is variation depending on the severity of the signs and symptoms. Most affected individuals die within a decade after signs and symptoms first appear, although some people with the disease have survived longer.

MalaCards: Hereditary Cerebral Amyloid Angiopathy, also known as autosomal dominant cerebrovascular amyloidosis, is related to cerebral amyloid angiopathy and amyloidosis. An important gene associated with Hereditary Cerebral Amyloid Angiopathy is APP (amyloid beta (A4) precursor protein), and among its related pathways are Neuroscience and Alzheimer's disease. The compounds thioflavine s and metrifonate have been mentioned in the context of this disorder. Related mouse phenotype other.

Aliases & Classifications for Hereditary Cerebral Amyloid Angiopathy

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21Genetics Home Reference, 45Novoseek, 62UMLS
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Classifications:



Aliases & Descriptions:

hereditary cerebral amyloid angiopathy 21 45
autosomal dominant cerebrovascular amyloidosis 21
cerebral amyloid angiopathy, hereditary 62
cerebral amyloid angiopathy, familial 21
cerebral amyloid angiopathy, genetic 21
cerebral amyloid angiopathy familial 45
hchwa 21
caa 21


Related Diseases for Hereditary Cerebral Amyloid Angiopathy

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17GeneCards, 18GeneDecks
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Diseases in the Cerebral Amyloid Angiopathy family:

hereditary cerebral amyloid angiopathy Cerebral Amyloid Angiopathy, Prnp-Related

Diseases related to Hereditary Cerebral Amyloid Angiopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral amyloid angiopathy31.2APP, APOE
2amyloidosis30.5APP, APOE
3dementia30.5APP, APOE
4alzheimer's disease29.9APP, APOE
5cerebritis10.8
6hereditary cerebral hemorrhage with amyloidosis10.3
7schizophrenia10.3
8congenital aural atresia10.3
9spinocerebellar ataxia10.2
10lysinuric protein intolerance10.2
11ataxia10.2
12thalassemia10.1
13catecholaminergic polymorphic ventricular tachycardia10.1
14spinocerebellar ataxia type 1710.1
15cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.1
16endotheliitis10.1
17inclusion body myositis10.1APP
18amyotrophic lateral sclerosis10.0APP
19stroke, hemorrhagic10.0APOE, APP
20binswanger's disease10.0APOE, APP
21alzheimer disease type 210.0APOE, APP
22hemorrhage, intracerebral10.0APOE, APP
23progressive supranuclear palsy10.0APP, APOE
24lewy body dementia10.0APOE, APP
25vascular dementia10.0APP, APOE
26creutzfeldt-jakob disease10.0APP, APOE
27pick's disease10.0APOE, APP
28amyloid tumor10.0APP, APOE
29cerebrovascular disease10.0APP, APOE
30memory impairment10.0APP, APOE
31frontotemporal dementia10.0APOE, APP
32prion disease10.0APP, APOE
33down syndrome10.0APP, APOE
34parkinson's disease9.9APP, APOE
35urethritis9.9
36palindromic rheumatism9.9
37timothy syndrome9.9
38alpha thalassemia9.9
39neuronitis9.9
40hereditary spastic paraplegia9.9
41neonatal diabetes mellitus9.9
42acute myocardial infarction9.9
43bipolar disorder9.9
44diabetes mellitus9.9
45dilated cardiomyopathy9.9
46liposarcoma9.9
47myocardial infarction9.9
48pancreatic cancer9.9
49pancreatitis9.9
50paraplegia9.9

Graphical network of the top 20 diseases related to Hereditary Cerebral Amyloid Angiopathy:



Diseases related to hereditary cerebral amyloid angiopathy

Symptoms for Hereditary Cerebral Amyloid Angiopathy

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Drugs & Therapeutics for Hereditary Cerebral Amyloid Angiopathy

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hereditary Cerebral Amyloid Angiopathy

Search NIH Clinical Center for Hereditary Cerebral Amyloid Angiopathy

Genetic Tests for Hereditary Cerebral Amyloid Angiopathy

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Anatomical Context for Hereditary Cerebral Amyloid Angiopathy

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Animal Models for Hereditary Cerebral Amyloid Angiopathy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hereditary Cerebral Amyloid Angiopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1APP, APOE

Publications for Hereditary Cerebral Amyloid Angiopathy

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52PubMed
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Articles related to Hereditary Cerebral Amyloid Angiopathy:

idTitleAuthorsYear
1
Vascular changes in Iowa-type hereditary cerebral amyloid angiopathy. (12480757)
2002
2
From gene to disease; amyloid-beta precursor protein gene instrumental in hereditary cerebral amyloid angiopathies]. (11552366)
2001
3
Dutch hereditary cerebral amyloid angiopathy: structural lesions and apolipoprotein E genotype. (9153536)
1997
4
No protective effect of apolipoprotein E epsilon 2 allele in Dutch hereditary cerebral amyloid angiopathy. (7847872)
1995
5
Progressive dementia, without cerebral hemorrhage, in a patient with hereditary cerebral amyloid angiopathy. (1335860)
1992
6
Comparison between the Icelandic and Dutch forms of hereditary cerebral amyloid angiopathy. (1320529)
1992
7
Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Research-Group Hereditary Cerebral Amyloid-Angiopathy. (2555088)
1989
8
Hereditary cerebral amyloid angiopathy: the amyloid fibrils contain a protein which is a variant of cystatin C, an inhibitor of lysosomal cysteine proteases. (3707586)
1986

Variations for Hereditary Cerebral Amyloid Angiopathy

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Expression for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

Search GEO for disease gene expression data for Hereditary Cerebral Amyloid Angiopathy.

Pathways for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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50PathCards, 5Cell Signaling Technology, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 54R&D Systems
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Pathways related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1APP, APOE
2
Show member pathways
Alzheimers Disease38
9.1APP, APOE
39.1APOE, APP
49.1APP, APOE
59.1APP, APOE

Compounds for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 29IUPHAR, 3BitterDB, 61Tocris Bioscience
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Compounds related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1thioflavine s459.5APP, APOE
2metrifonate459.5APP, APOE
324s-hydroxy-cholesterol459.5APP, APOE
4thioflavin t459.5APP, APOE
5tacrine45 1110.5APOE, APP
6donepezil45 51 24 1112.5APP, APOE
7galantamine45 51 1111.5APP, APOE
8formate459.5APP, APOE
9ibuprofen45 29 51 24 1113.5APOE, APP
104-hydroxynonenal45 2410.5APP, APOE
11chloroquine45 3 51 29 1113.5APP, APOE
12lactacystin459.5APP, APOE
13lovastatin45 51 61 29 1113.5APOE, APP
14sodium dodecylsulfate459.5APP, APOE
15simvastatin45 51 61 29 24 1114.5APP, APOE
16folate459.4APP, APOE
17nicotine45 29 51 1112.4APOE, APP
18valine459.4APP, APOE
19vitamin a45 24 1111.4APP, APOE
20aspirin45 51 29 2412.4APP, APOE
21nmda45 2910.4APOE, APP
22acetylcholine45 51 29 24 1113.4APP, APOE
23actinomycin d459.4APP, APOE
24cyclosporin a45 29 6111.3APP, APOE
25glutamine459.3APOE, APP
26dopamine45 29 24 1112.3APP, APOE
27creatinine459.2APP, APOE
28aspartate459.2APP, APOE
29heparin45 29 24 1112.1APOE, APP
30cholesterol45 29 24 1112.1APP, APOE
31h2o2459.0APP, APOE
32testosterone45 61 24 1111.8APP, APOE

GO Terms for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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16Gene Ontology
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Cellular components related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:0057949.1APP, APOE

Biological processes related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol metabolic processGO:0082039.1APP, APOE

Molecular functions related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1APP, APOE
2heparin bindingGO:0082018.8APP, APOE

Products for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hereditary Cerebral Amyloid Angiopathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet