CAA
MCID: HRD084
MIFTS: 34

Hereditary Cerebral Amyloid Angiopathy (CAA) malady

Genetic diseases, Cardiovascular diseases, Neuronal diseases, Bone diseases, Rare diseases, Metabolic diseases categories
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Summaries for Hereditary Cerebral Amyloid Angiopathy

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Genetics Home Reference:21 Hereditary cerebral amyloid angiopathy is a condition that can cause a progressive loss of intellectual function (dementia), stroke, and other neurological problems starting in mid-adulthood. Due to neurological decline, this condition is typically fatal in one's sixties, although there is variation depending on the severity of the signs and symptoms. Most affected individuals die within a decade after signs and symptoms first appear, although some people with the disease have survived longer.

MalaCards based summary: Hereditary Cerebral Amyloid Angiopathy, also known as autosomal dominant cerebrovascular amyloidosis, is related to cerebral amyloid angiopathy and amyloidosis. An important gene associated with Hereditary Cerebral Amyloid Angiopathy is APP (amyloid beta (A4) precursor protein), and among its related pathways are Neuroscience and Alzheimer's disease. The compounds thioflavine s and metrifonate have been mentioned in the context of this disorder. Related mouse phenotype other.

Aliases & Classifications for Hereditary Cerebral Amyloid Angiopathy

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Hereditary Cerebral Amyloid Angiopathy, Aliases & Descriptions:

Name: Hereditary Cerebral Amyloid Angiopathy 21 44
Autosomal Dominant Cerebrovascular Amyloidosis 21 62
Cerebral Amyloid Angiopathy, Hereditary 62
Cerebral Amyloid Angiopathy, Familial 21
 
Cerebral Amyloid Angiopathy, Genetic 21
Cerebral Amyloid Angiopathy Familial 44
Hchwa 21
Caa 21


Classifications:



Related Diseases for Hereditary Cerebral Amyloid Angiopathy

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Diseases in the Cerebral Amyloid Angiopathy family:

hereditary cerebral amyloid angiopathy Cerebral Amyloid Angiopathy, Prnp-Related

Diseases related to Hereditary Cerebral Amyloid Angiopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral amyloid angiopathy31.3APP, APOE
2amyloidosis30.4APP, APOE
3dementia30.3APOE, APP
4alzheimer's disease29.7APP, APOE
5cerebritis10.8
6cerebral hemorrhage10.5
7hereditary cerebral hemorrhage with amyloidosis10.3
8schizophrenia10.3
9congenital aural atresia10.3
10inclusion body myositis10.3APP
11spinocerebellar ataxia10.2
12lysinuric protein intolerance10.2
13ataxia10.2
14endotheliitis10.2
15thalassemia10.1
16catecholaminergic polymorphic ventricular tachycardia10.1
17spinocerebellar ataxia type 1710.1
18cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.1
19amyotrophic lateral sclerosis type 1410.1APP
20binswanger's disease10.0APOE, APP
21stroke, hemorrhagic10.0APP, APOE
22alzheimer disease type 210.0APP, APOE
23hemorrhage, intracerebral10.0APOE, APP
24progressive supranuclear palsy10.0APOE, APP
25lewy body dementia10.0APOE, APP
26vascular dementia10.0APOE, APP
27creutzfeldt-jakob disease10.0APP, APOE
28pick's disease10.0APOE, APP
29amyloid tumor10.0APOE, APP
30cerebrovascular disease10.0APOE, APP
31memory impairment10.0APOE, APP
32frontotemporal dementia10.0APP, APOE
33acute myocardial infarction9.9
34bipolar disorder9.9
35chronic obstructive pulmonary disease9.9
36diabetes mellitus9.9
37dilated cardiomyopathy9.9
38hereditary spastic paraplegia9.9
39myocardial infarction9.9
40pancreatic cancer9.9
41prostate cancer9.9
42urethritis9.9
43palindromic rheumatism9.9
44alpha thalassemia9.9
45neonatal diabetes mellitus9.9
46timothy syndrome9.9
47neuronitis9.9
48liposarcoma9.9
49pancreatitis9.9
50paraplegia9.9

Graphical network of the top 20 diseases related to Hereditary Cerebral Amyloid Angiopathy:



Diseases related to hereditary cerebral amyloid angiopathy

Symptoms for Hereditary Cerebral Amyloid Angiopathy

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Drugs & Therapeutics for Hereditary Cerebral Amyloid Angiopathy

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Drug clinical trials:

Search ClinicalTrials for Hereditary Cerebral Amyloid Angiopathy

Search NIH Clinical Center for Hereditary Cerebral Amyloid Angiopathy

Genetic Tests for Hereditary Cerebral Amyloid Angiopathy

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Anatomical Context for Hereditary Cerebral Amyloid Angiopathy

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Animal Models for Hereditary Cerebral Amyloid Angiopathy or affiliated genes

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MGI Mouse Phenotypes related to Hereditary Cerebral Amyloid Angiopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1APP, APOE

Publications for Hereditary Cerebral Amyloid Angiopathy

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Articles related to Hereditary Cerebral Amyloid Angiopathy:

idTitleAuthorsYear
1
Vascular changes in Iowa-type hereditary cerebral amyloid angiopathy. (12480757)
2002
2
From gene to disease; amyloid-beta precursor protein gene instrumental in hereditary cerebral amyloid angiopathies]. (11552366)
2001
3
Dutch hereditary cerebral amyloid angiopathy: structural lesions and apolipoprotein E genotype. (9153536)
1997
4
No protective effect of apolipoprotein E epsilon 2 allele in Dutch hereditary cerebral amyloid angiopathy. (7847872)
1995
5
Progressive dementia, without cerebral hemorrhage, in a patient with hereditary cerebral amyloid angiopathy. (1335860)
1992
6
Comparison between the Icelandic and Dutch forms of hereditary cerebral amyloid angiopathy. (1320529)
1992
7
Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Research-Group Hereditary Cerebral Amyloid-Angiopathy. (2555088)
1989
8
Hereditary cerebral amyloid angiopathy: the amyloid fibrils contain a protein which is a variant of cystatin C, an inhibitor of lysosomal cysteine proteases. (3707586)
1986

Variations for Hereditary Cerebral Amyloid Angiopathy

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Expression for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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Expression patterns in normal tissues for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

Search GEO for disease gene expression data for Hereditary Cerebral Amyloid Angiopathy.

Pathways for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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Pathways related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1APP, APOE
2
Show member pathways
Alzheimers Disease37
9.1APP, APOE
39.1APOE, APP
49.1APP, APOE
59.1APP, APOE

Compounds for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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Compounds related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1thioflavine s449.5APP, APOE
2metrifonate449.5APP, APOE
324s-hydroxy-cholesterol449.5APP, APOE
4thioflavin t449.5APP, APOE
5tacrine44 1110.5APOE, APP
6donepezil44 50 24 1112.5APP, APOE
7galantamine44 50 1111.5APP, APOE
8formate449.5APP, APOE
9ibuprofen44 28 50 24 1113.5APOE, APP
104-hydroxynonenal44 2410.5APP, APOE
11chloroquine44 2 50 28 1113.5APP, APOE
12lactacystin449.5APP, APOE
13lovastatin44 50 61 28 1113.5APOE, APP
14sodium dodecylsulfate449.5APP, APOE
15simvastatin44 50 61 28 24 1114.5APP, APOE
16folate449.4APP, APOE
17nicotine44 28 50 1112.4APOE, APP
18valine449.4APP, APOE
19vitamin a44 24 1111.4APP, APOE
20aspirin44 50 28 2412.4APP, APOE
21nmda44 2810.4APOE, APP
22acetylcholine44 50 28 24 1113.4APP, APOE
23actinomycin d449.4APP, APOE
24cyclosporin a44 28 6111.3APP, APOE
25glutamine449.3APOE, APP
26dopamine44 28 24 1112.3APP, APOE
27creatinine449.2APP, APOE
28aspartate449.2APP, APOE
29heparin44 28 24 1112.1APOE, APP
30cholesterol44 28 24 1112.1APP, APOE
31h2o2449.0APP, APOE
32testosterone44 61 24 1111.8APP, APOE

GO Terms for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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Cellular components related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:0057949.1APP, APOE

Biological processes related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol metabolic processGO:0082039.1APP, APOE

Molecular functions related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1APP, APOE
2heparin bindingGO:0082018.8APP, APOE

Products for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hereditary Cerebral Amyloid Angiopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet