CAA
MCID: HRD084
MIFTS: 28

Hereditary Cerebral Amyloid Angiopathy (CAA) malady

Genetic category

Summaries for Hereditary Cerebral Amyloid Angiopathy

Sources:
21Genetics Home Reference, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Genetics Home Reference:21 Hereditary cerebral amyloid angiopathy is a condition that can cause a progressive loss of intellectual function (dementia), stroke, and other neurological problems starting in mid-adulthood. Due to neurological decline, this condition is typically fatal in one's sixties, although there is variation depending on the severity of the signs and symptoms. Most affected individuals die within a decade after signs and symptoms first appear, although some people with the disease have survived longer.

MalaCards: Hereditary Cerebral Amyloid Angiopathy, also known as autosomal dominant cerebrovascular amyloidosis, is related to cerebral amyloid angiopathy and amyloidosis. An important gene associated with Hereditary Cerebral Amyloid Angiopathy is APP (amyloid beta (A4) precursor protein), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Neuroscience. The compounds thioflavine s and metrifonate have been mentioned in the context of this disorder. Related mouse phenotype other.

Aliases & Classifications for Hereditary Cerebral Amyloid Angiopathy

Sources:
21Genetics Home Reference, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic


Aliases & Descriptions:

hereditary cerebral amyloid angiopathy 21 45
autosomal dominant cerebrovascular amyloidosis 21
cerebral amyloid angiopathy, hereditary 61
cerebral amyloid angiopathy, familial 21
cerebral amyloid angiopathy, genetic 21
cerebral amyloid angiopathy familial 45
hchwa 21
caa 21


Related Diseases for Hereditary Cerebral Amyloid Angiopathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hereditary Cerebral Amyloid Angiopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral amyloid angiopathy31.1APOE, APP
2amyloidosis30.4APP, APOE
3amyloidosis cerebral10.3
4hereditary amyloidosis10.3
5hereditary cerebral hemorrhage with amyloidosis10.2
6spinocerebellar ataxia10.2
7lysinuric protein intolerance10.2
8ataxia10.2
9thalassemia10.1
10catecholaminergic polymorphic ventricular tachycardia10.1
11cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.1
12amyloidosis, secondary10.0
13lewy body dementia10.0APOE
14vascular dementia10.0APOE
15hyperhomocysteinemia10.0APOE
16hypercholesterolemia10.0APOE
17coronary heart disease10.0APOE
18inclusion body myositis10.0APP
19age related macular degeneration10.0APOE
20myositis10.0APP
21binswanger's disease10.0APP, APOE
22stroke, hemorrhagic10.0APP, APOE
23alzheimer disease type 210.0APP, APOE
24hemorrhage, intracerebral10.0APP, APOE
25progressive supranuclear palsy10.0APOE, APP
26creutzfeldt-jakob syndrome10.0APOE, APP
27amyloid tumor10.0APOE, APP
28memory impairment10.0APP, APOE
29pick's disease10.0APOE, APP
30prion disease10.0APOE, APP
31encephalitis10.0APP
32frontotemporal dementia10.0APOE, APP
33cerebrovascular disease10.0APOE, APP
34parkinson's disease10.0APOE, APP
35coronary aneurysm9.9
36palindromic rheumatism9.9
37timothy syndrome9.9
38alpha thalassemia9.9
39hereditary spastic paraplegia9.9
40neonatal diabetes mellitus9.9
41alzheimer's disease9.9
42bipolar i disorder9.9
43n syndrome9.9
44acute myocardial infarction9.9
45bipolar disorder9.9
46urethral obstruction9.9
47vasculitis9.9
48sickle cell disease9.9
49familial dilated cardiomyopathy9.9
50coronary artery aneurysm9.9

Graphical network of the top 20 diseases related to Hereditary Cerebral Amyloid Angiopathy:



Diseases related to hereditary cerebral amyloid angiopathy

Clinical Features for Hereditary Cerebral Amyloid Angiopathy

Drugs & Therapeutics for Hereditary Cerebral Amyloid Angiopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hereditary Cerebral Amyloid Angiopathy

Drug clinical trials:

Search ClinicalTrials for Hereditary Cerebral Amyloid Angiopathy

Search NIH Clinical Center for Hereditary Cerebral Amyloid Angiopathy

Search CenterWatch for Hereditary Cerebral Amyloid Angiopathy

Genetic Tests for Hereditary Cerebral Amyloid Angiopathy

Anatomical Context for Hereditary Cerebral Amyloid Angiopathy

Animal Models for Hereditary Cerebral Amyloid Angiopathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hereditary Cerebral Amyloid Angiopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1APOE, APP

Publications for Hereditary Cerebral Amyloid Angiopathy

Sources:
51PubMed
See all sources

Articles related to Hereditary Cerebral Amyloid Angiopathy:

(show all 12)
idTitleAuthorsYear
1
Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion. (17629591)
2009
2
Hereditary dementia with intracerebral hemorrhages and cerebral amyloid angiopathy. (15277614)
2004
3
Vascular changes in Iowa-type hereditary cerebral amyloid angiopathy. (12480757)
2002
4
Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles. (11761474)
2001
5
Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D). (9542588)
1998
6
Dutch hereditary cerebral amyloid angiopathy: structural lesions and apolipoprotein E genotype. (9153536)
1997
7
No protective effect of apolipoprotein E epsilon 2 allele in Dutch hereditary cerebral amyloid angiopathy. (7847872)
1995
8
Progressive dementia, without cerebral hemorrhage, in a patient with hereditary cerebral amyloid angiopathy. (1335860)
1992
9
Comparison between the Icelandic and Dutch forms of hereditary cerebral amyloid angiopathy. (1320529)
1992
10
Hereditary cerebral hemorrhage with amyloidosis--Dutch type: a congophilic angiopathy. An overview. (1776734)
1991
11
Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Research-Group Hereditary Cerebral Amyloid-Angiopathy. (2555088)
1989
12
Hereditary cerebral amyloid angiopathy: the amyloid fibrils contain a protein which is a variant of cystatin C, an inhibitor of lysosomal cysteine proteases. (3707586)
1986

Genetic Variations for Hereditary Cerebral Amyloid Angiopathy

Expression for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

Search GEO for disease gene expression data for Hereditary Cerebral Amyloid Angiopathy.

Pathways for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN, 53R&D Systems
See all sources

Pathways related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1APOE, APP
29.1APOE, APP
39.1APP, APOE
49.1APOE, APP
59.1APOE, APP

Compounds for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1thioflavine s459.5APOE, APP
2metrifonate459.5APOE, APP
324s-hydroxy-cholesterol459.5APOE, APP
4thioflavin t459.5APP, APOE
5tacrine45 1110.5APOE, APP
6donepezil45 11 2411.5APOE, APP
7galantamine45 50 1111.5APOE, APP
8formate459.5APP, APOE
9ibuprofen45 29 50 11 2413.5APOE, APP
104-hydroxynonenal45 2410.5APOE, APP
11chloroquine45 2 50 29 1113.5APOE, APP
12lactacystin459.5APP, APOE
13lovastatin45 50 60 29 1113.4APOE, APP
14sodium dodecylsulfate459.4APOE, APP
15simvastatin45 50 60 29 11 2414.4APP, APOE
16folate459.4APOE, APP
17nicotine45 50 29 1112.4APOE, APP
18valine459.4APOE, APP
19vitamin a45 11 2411.4APP, APOE
20aspirin45 50 29 2412.4APOE, APP
21nmda45 2910.3APOE, APP
22acetylcholine45 50 29 11 2413.3APP, APOE
23actinomycin d459.3APOE, APP
24cyclosporin a45 29 6011.2APOE, APP
25glutamine459.2APOE, APP
26dopamine45 29 11 2412.1APP, APOE
27heparin45 29 11 2412.1APOE, APP
28creatinine459.0APOE, APP
29aspartate458.8APOE, APP

GO Terms for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

Sources:
16Gene Ontology
See all sources

Biological processes related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol metabolic processGO:0082039.1APOE, APP

Molecular functions related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1APOE, APP
2heparin bindingGO:0082018.8APOE, APP

Products for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hereditary Cerebral Amyloid Angiopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet