CAA
MCID: HRD084
MIFTS: 32

Hereditary Cerebral Amyloid Angiopathy (CAA) malady

Genetic diseases, Cardiovascular diseases, Neuronal diseases, Bone diseases, Rare diseases categories

Summaries for Hereditary Cerebral Amyloid Angiopathy

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22Genetics Home Reference, 34MalaCards
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Genetics Home Reference:22 Hereditary cerebral amyloid angiopathy is a condition that can cause a progressive loss of intellectual function (dementia), stroke, and other neurological problems starting in mid-adulthood. Due to neurological decline, this condition is typically fatal in one's sixties, although there is variation depending on the severity of the signs and symptoms. Most affected individuals die within a decade after signs and symptoms first appear, although some people with the disease have survived longer.

MalaCards: Hereditary Cerebral Amyloid Angiopathy, also known as autosomal dominant cerebrovascular amyloidosis, is related to cerebral amyloid angiopathy and amyloidosis. An important gene associated with Hereditary Cerebral Amyloid Angiopathy is APP (amyloid beta (A4) precursor protein), and among its related pathways are Neuroscience and Alzheimer's disease. The compounds thioflavine s and metrifonate have been mentioned in the context of this disorder. Related mouse phenotype other.

Aliases & Classifications for Hereditary Cerebral Amyloid Angiopathy

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22Genetics Home Reference, 46Novoseek, 63UMLS
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Classifications:



Aliases & Descriptions:

hereditary cerebral amyloid angiopathy 22 46
autosomal dominant cerebrovascular amyloidosis 22
cerebral amyloid angiopathy, hereditary 63
cerebral amyloid angiopathy, familial 22
cerebral amyloid angiopathy, genetic 22
cerebral amyloid angiopathy familial 46
hchwa 22
caa 22


Related Diseases for Hereditary Cerebral Amyloid Angiopathy

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18GeneCards, 19GeneDecks
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Diseases in the Cerebral Amyloid Angiopathy family:

hereditary cerebral amyloid angiopathy Cerebral Amyloid Angiopathy, Prnp-Related

Diseases related to Hereditary Cerebral Amyloid Angiopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral amyloid angiopathy31.2APP, APOE
2amyloidosis30.5APP, APOE
3dementia30.5APP, APOE
4alzheimer's disease29.9APP, APOE
5cerebritis10.8
6hereditary cerebral hemorrhage with amyloidosis10.3
7schizophrenia10.3
8congenital aural atresia10.3
9spinocerebellar ataxia10.2
10lysinuric protein intolerance10.2
11ataxia10.2
12thalassemia10.1
13catecholaminergic polymorphic ventricular tachycardia10.1
14spinocerebellar ataxia type 1710.1
15cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.1
16endotheliitis10.1
17inclusion body myositis10.1APP
18amyotrophic lateral sclerosis10.0APP
19stroke, hemorrhagic10.0APOE, APP
20binswanger's disease10.0APOE, APP
21alzheimer disease type 210.0APOE, APP
22hemorrhage, intracerebral10.0APOE, APP
23progressive supranuclear palsy10.0APP, APOE
24lewy body dementia10.0APOE, APP
25vascular dementia10.0APP, APOE
26creutzfeldt-jakob disease10.0APP, APOE
27pick's disease10.0APOE, APP
28amyloid tumor10.0APP, APOE
29cerebrovascular disease10.0APP, APOE
30memory impairment10.0APP, APOE
31frontotemporal dementia10.0APOE, APP
32prion disease10.0APP, APOE
33down syndrome10.0APP, APOE
34parkinson's disease9.9APP, APOE
35urethritis9.9
36palindromic rheumatism9.9
37timothy syndrome9.9
38alpha thalassemia9.9
39neuronitis9.9
40hereditary spastic paraplegia9.9
41neonatal diabetes mellitus9.9
42acute myocardial infarction9.9
43bipolar disorder9.9
44diabetes mellitus9.9
45dilated cardiomyopathy9.9
46liposarcoma9.9
47myocardial infarction9.9
48pancreatic cancer9.9
49pancreatitis9.9
50paraplegia9.9

Graphical network of the top 20 diseases related to Hereditary Cerebral Amyloid Angiopathy:



Diseases related to hereditary cerebral amyloid angiopathy

Symptoms for Hereditary Cerebral Amyloid Angiopathy

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Drugs & Therapeutics for Hereditary Cerebral Amyloid Angiopathy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hereditary Cerebral Amyloid Angiopathy

Drug clinical trials:

Search ClinicalTrials for Hereditary Cerebral Amyloid Angiopathy

Search NIH Clinical Center for Hereditary Cerebral Amyloid Angiopathy

Search CenterWatch for Hereditary Cerebral Amyloid Angiopathy

Genetic Tests for Hereditary Cerebral Amyloid Angiopathy

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Anatomical Context for Hereditary Cerebral Amyloid Angiopathy

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Animal Models for Hereditary Cerebral Amyloid Angiopathy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hereditary Cerebral Amyloid Angiopathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1APP, APOE

Publications for Hereditary Cerebral Amyloid Angiopathy

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53PubMed
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Articles related to Hereditary Cerebral Amyloid Angiopathy:

idTitleAuthorsYear
1
Vascular changes in Iowa-type hereditary cerebral amyloid angiopathy. (12480757)
2002
2
From gene to disease; amyloid-beta precursor protein gene instrumental in hereditary cerebral amyloid angiopathies]. (11552366)
2001
3
Dutch hereditary cerebral amyloid angiopathy: structural lesions and apolipoprotein E genotype. (9153536)
1997
4
No protective effect of apolipoprotein E epsilon 2 allele in Dutch hereditary cerebral amyloid angiopathy. (7847872)
1995
5
Progressive dementia, without cerebral hemorrhage, in a patient with hereditary cerebral amyloid angiopathy. (1335860)
1992
6
Comparison between the Icelandic and Dutch forms of hereditary cerebral amyloid angiopathy. (1320529)
1992
7
Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Research-Group Hereditary Cerebral Amyloid-Angiopathy. (2555088)
1989
8
Hereditary cerebral amyloid angiopathy: the amyloid fibrils contain a protein which is a variant of cystatin C, an inhibitor of lysosomal cysteine proteases. (3707586)
1986

Variations for Hereditary Cerebral Amyloid Angiopathy

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Expression for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

Search GEO for disease gene expression data for Hereditary Cerebral Amyloid Angiopathy.

Pathways for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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51PathCards, 5Cell Signaling Technology, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 55R&D Systems
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Pathways related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1APP, APOE
2
Show member pathways
Alzheimers Disease39
9.1APP, APOE
39.1APOE, APP
49.1APP, APOE
59.1APP, APOE

Compounds for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 30IUPHAR, 3BitterDB, 62Tocris Bioscience
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Compounds related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1thioflavine s469.5APP, APOE
2metrifonate469.5APP, APOE
324s-hydroxy-cholesterol469.5APP, APOE
4thioflavin t469.5APP, APOE
5tacrine46 1210.5APOE, APP
6donepezil46 52 25 1212.5APP, APOE
7galantamine46 52 1211.5APP, APOE
8formate469.5APP, APOE
9ibuprofen46 30 52 25 1213.5APOE, APP
104-hydroxynonenal46 2510.5APP, APOE
11chloroquine46 3 52 30 1213.5APP, APOE
12lactacystin469.5APP, APOE
13lovastatin46 52 62 30 1213.5APOE, APP
14sodium dodecylsulfate469.5APP, APOE
15simvastatin46 52 62 30 25 1214.5APP, APOE
16folate469.4APP, APOE
17nicotine46 30 52 1212.4APOE, APP
18valine469.4APP, APOE
19vitamin a46 25 1211.4APP, APOE
20aspirin46 52 30 2512.4APP, APOE
21nmda46 3010.4APOE, APP
22acetylcholine46 52 30 25 1213.4APP, APOE
23actinomycin d469.4APP, APOE
24cyclosporin a46 30 6211.3APP, APOE
25glutamine469.3APOE, APP
26dopamine46 30 25 1212.3APP, APOE
27creatinine469.2APP, APOE
28aspartate469.2APP, APOE
29heparin46 30 25 1212.1APOE, APP
30cholesterol46 30 25 1212.1APP, APOE
31h2o2469.0APP, APOE
32testosterone46 62 25 1211.8APP, APOE

GO Terms for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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17Gene Ontology
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Cellular components related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:0057949.1APP, APOE

Biological processes related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol metabolic processGO:0082039.1APP, APOE

Molecular functions related to Hereditary Cerebral Amyloid Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1APP, APOE
2heparin bindingGO:0082018.8APP, APOE

Products for genes affiliated with Hereditary Cerebral Amyloid Angiopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hereditary Cerebral Amyloid Angiopathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet