Hereditary Cerebral Amyloid Angiopathy malady

Genetics Home Reference: Hereditary cerebral amyloid angiopathy is a condition that can cause a progressive loss of intellectual function (dementia), stroke, and other neurological problems starting in mid-adulthood. Due to neurological decline, this condition is typically fatal in one's sixties, although there is variation depending on the severity of the signs and symptoms. Most affected individuals die within a decade after signs and symptoms first appear, although some people with the disease have survived longer.¹⁷

MalaCards: Hereditary Cerebral Amyloid Angiopathy, also known as cerebral amyloid angiopathy, is related to alzheimer's disease and cerebral amyloid angiopathy. An important gene associated with Hereditary Cerebral Amyloid Angiopathy is APP (amyloid beta (A4) precursor protein), and among its related pathways are Alzheimers disease and Alzheimers Disease Pathway. The compounds thioflavine s and metrifonate have been mentioned in the context of this disorder. Related mouse phenotype other.

hereditary cerebral amyloid angiopathy 17 32 cerebral amyloid angiopathy 17 43 autosomal dominant cerebrovascular amyloidosis 17 cerebral amyloid angiopathy, hereditary 43 cerebral amyloid angiopathy, familial 17

cerebral amyloid angiopathy familial 32 cerebral amyloid angiopathy, genetic 17 hchwa 17 caa 17

Diseases related to hereditary cerebral amyloid angiopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 68)

id	Related Disease	Score	Top Affiliating Genes
1	alzheimer's disease	36.0	APOE, APP
2	cerebral amyloid angiopathy	33.4	APOE, APP
3	cerebral hemorrhage	31.3	APP, APOE
4	arteriosclerosis	31.2	APP, APOE
5	polyneuropathy	31.1	APOE, APP
6	vascular dementia	29.9	APOE, APP
7	traumatic brain injury	29.8	APOE, APP
8	amyloidosis	29.7	APP, APOE
9	brain injury	29.5	APOE, APP
10	alzheimer disease type 1	12.6	APOE, APP
11	binswanger's disease	12.6	APP, APOE
12	alzheimer disease type 2	12.6	APP, APOE
13	beriberi	12.6	APP, APOE
14	progressive supranuclear palsy	12.6	APP, APOE
15	cognitive disease	12.6	APP, APOE
16	cadasil	12.6	APP, APOE
17	creutzfeldt-jakob syndrome	12.6	APP, APOE
18	lewy body dementia	12.6	APOE, APP
19	amyloid tumor	12.6	APOE, APP
20	memory impairment	12.5	APP, APOE
21	aphasia	12.5	APP, APOE
22	scrapie	12.5	APP, APOE
23	head injury	12.5	APP, APOE
24	tauopathy	12.5	APP, APOE
25	wilson disease	12.5	APP, APOE
26	supranuclear palsy	12.5	APOE, APP
27	inclusion body myositis	12.5	APOE, APP
28	pick's disease	12.5	APP, APOE
29	frontotemporal dementia	12.5	APP, APOE
30	headache	12.5	APP, APOE
31	hyperhomocysteinemia	12.5	APOE, APP
32	hydrocephalus	12.5	APOE, APP
33	cerebrovascular disease	12.5	APP, APOE
34	myositis	12.4	APOE, APP
35	was-related disorders	12.4	APOE, APP
36	oculomotor apraxia cogan type	12.4	APP, APOE
37	age related macular degeneration	12.4	APP, APOE
38	hypercholesterolemia	12.4	APOE, APP
39	parkinson's disease	12.3	APP, APOE
40	prion disease	12.3	APP, APOE
41	encephalitis	12.2	APOE, APP
42	conjunctivitis	12.2	APOE, APP
43	meningitis	12.1	APOE, APP
44	homocysteine	12.1	APOE, APP
45	neurodegenerative disease	12.0	APP, APOE
46	macular degeneration	11.8	APP, APOE
47	dementia	9.5
48	cerebritis	8.8
49	cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants	8.8
50	hereditary cerebral hemorrhage with amyloidosis	8.3

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to hereditary cerebral amyloid angiopathy:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	other phenotype	MP:0005395	9.1	APOE, APP

Articles related to hereditary cerebral amyloid angiopathy:

id	Title	Authors	Year	Affiliating Genes
1	From gene to disease; amyloid-beta precursor protein gene instrumental in hereditary cerebral amyloid angiopathies (11552366)	Haan J.... Roos R.A.	2001	APP
2	Dutch hereditary cerebral amyloid angiopathy: structural lesions and apolipoprotein E genotype. (9153536)	Bornebroek M.... Roos R.A.	1997	APOE

Genes related to hereditary cerebral amyloid angiopathy according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	APP	amyloid beta (A4) precursor protein	11.0	Publications
2	APOE	apolipoprotein E	11.0	Publications

Pathways related to hereditary cerebral amyloid angiopathy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Alzheimers disease20	9.1	APOE, APP
2	Alzheimers Disease Pathway36	9.0	APOE, APP
3	Reelin Pathway (Cajal-Retzius cells)36	8.8	APOE, APP

Compounds related to hereditary cerebral amyloid angiopathy according to GeneDecks:

(show all 25)

id	Compound	Score	Top Affiliating Genes
1	thioflavine s32	9.5	APOE, APP
2	metrifonate32	9.5	APP, APOE
3	24s-hydroxy-cholesterol32	9.5	APP, APOE
4	thioflavin t32	9.5	APOE, APP
5	tacrine32 9 9	11.5	APP, APOE
6	donepezil32 9 18 9	12.5	APP, APOE
7	galantamine32 34 9 9	12.5	APOE, APP
8	formate32	9.5	APOE, APP
9	ibuprofen32 9 18 9	12.4	APP, APOE
10	chloroquine32 34 9 9	12.4	APOE, APP
11	4-hydroxynonenal32 18	10.4	APOE, APP
12	lovastatin32 42 9 9	12.4	APOE, APP
13	lactacystin32	9.4	APP, APOE
14	sodium dodecylsulfate32	9.4	APP, APOE
15	simvastatin32 34 42 9 18 9	14.4	APP, APOE
16	nicotine32 34 9 9	12.4	APOE, APP
17	folate32	9.3	APP, APOE
18	valine32	9.3	APP, APOE
19	aspirin32 34 18	11.3	APP, APOE
20	vitamin a32 9 18 9	12.2	APP, APOE
21	nmda32 42	10.2	APOE, APP
22	acetylcholine32 9 18 9	12.1	APP, APOE
23	glutamine32	9.1	APOE, APP
24	actinomycin d32	9.0	APOE, APP
25	cyclosporin a32 42	9.8	APP, APOE

Molecular functions related to hereditary cerebral amyloid angiopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:042802	9.1	APOE, APP
2	heparin binding	GO:008201	8.8	APOE, APP