MCID: HRD008
MIFTS: 72

Hereditary Hemorrhagic Telangiectasia malady

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases, Neuronal diseases, Eye diseases, Liver diseases, Bone diseases, Skin diseases, Fetal diseases

Aliases & Classifications for Hereditary Hemorrhagic Telangiectasia

About this section
Sources:
33LifeMap Discovery®, 11Disease Ontology, 69Wikipedia, 22GeneReviews, 46NIH Rare Diseases, 23GeneTests, 24Genetics Home Reference, 13DISEASES, 52Orphanet, 66UMLS, 25GTR, 48Novoseek, 37MeSH, 28ICD10, 30ICD9CM, 43NCIt, 67UMLS via Orphanet, 29ICD10 via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Hereditary Hemorrhagic Telangiectasia:

Name: Hereditary Hemorrhagic Telangiectasia 33 11 69 22 46 23 24 13 52 66
Hht 22 46 23 24 52
Rendu-Osler-Weber Disease 11 46 52
Osler-Weber-Rendu Disease 11 22 23
Osler Hemorrhagic Telangiectasia 23 25
Osler Hemorrhagic Telangiectasia Syndrome 11
Telangiectasia, Hereditary Hemorrhagic 37
 
Telangiectasia Hereditary Hemorrhagic 48
Osler-Weber-Rendu Syndrome 24
Osler Weber Rendu Syndrome 46
Osler-Rendu-Weber Disease 46
Rendu-Osler Disease 52
Orw Disease 46

Characteristics:

Orphanet epidemiological data:

52
hereditary hemorrhagic telangiectasia:
Inheritance: Autosomal dominant; Prevalence: 1-5/10000 (Europe),1-5/10000 (France),1-9/100000 (United Kingdom),1-5/10000 (Denmark),1-5/10000 (Japan),1-9/100000 (United States),1-5/10000; Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:1270
ICD1028 I78.0
ICD9CM30 448.0
MeSH37 D013683
NCIt43 C35064
Orphanet52 ORPHA774
UMLS via Orphanet67 C0039445
ICD10 via Orphanet29 I78.0

Summaries for Hereditary Hemorrhagic Telangiectasia

About this section
NIH Rare Diseases:46 Hereditary hemorrhagic telangiectasia (hht) is an inherited disorder of the blood vessels that can cause excessive bleeding. people with this condition can develop abnormal blood vessels called arteriovenous malformations (avms) in several areas of the body. if they are on the skin, they are called telangiectasias. the avms can also develop in other parts of the body, such as the brain, lungs, liver, or intestines. hht is caused by mutations in several genes, including acvrl1, eng, smad4, and gdf2. at least 2 additional as-yet-unknown genes are also suspected. it is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. there is no cure for hht. treatment is symptomatic and supportive, with a focus on controlling bleeding, either through surgery or medication. last updated: 4/20/2016

MalaCards based summary: Hereditary Hemorrhagic Telangiectasia, also known as hht, is related to colorectal cancer and juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, and has symptoms including epistaxis, telangiectasia of the skin and cavernous hemangioma. An important gene associated with Hereditary Hemorrhagic Telangiectasia is SMAD4 (SMAD Family Member 4), and among its related pathways are NTHi-Induced Signaling and Cardiomyocyte Differentiation through BMP Receptors. Affiliated tissues include liver, skin and brain, and related mouse phenotypes are liver/biliary system and neoplasm.

Disease Ontology:11 An autosomal dominant disease characterized by the presence of multiple arteriovenous malformations that lack intervening capillaries and result in direct connections between arteries and veins.

Genetics Home Reference:24 Hereditary hemorrhagic telangiectasia is a disorder that results in the development of multiple abnormalities in the blood vessels.

Wikipedia:69 Hereditary hemorrhagic telangiectasia (HHT), also known as Osler–Weber–Rendu disease and... more...

GeneReviews summary for NBK1351

Related Diseases for Hereditary Hemorrhagic Telangiectasia

About this section

Diseases in the Hereditary Hemorrhagic Telangiectasia family:

Telangiectasia, Hereditary Hemorrhagic, Type 3 Telangiectasia, Hereditary Hemorrhagic, Type 4
Telangiectasia, Hereditary Hemorrhagic, Type 1 Telangiectasia, Hereditary Hemorrhagic, Type 5
Telangiectasia, Hereditary Hemorrhagic, Type 2 Acvrl1-Related Hereditary Hemorrhagic Telangiectasia
Eng-Related Hereditary Hemorrhagic Telangiectasia Gdf2-Related Hereditary Hemorrhagic Telangiectasia
Smad4-Related Hereditary Hemorrhagic Telangiectasia

Diseases related to Hereditary Hemorrhagic Telangiectasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer26.9BMP6, ENG, SMAD4, SP1, TGFB1, TGFB2
2juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome12.5
3acvrl1-related hereditary hemorrhagic telangiectasia12.2
4eng-related hereditary hemorrhagic telangiectasia12.2
5gdf2-related hereditary hemorrhagic telangiectasia12.1
6smad4-related hereditary hemorrhagic telangiectasia12.1
7telangiectasia, hereditary hemorrhagic, type 111.5
8telangiectasia, hereditary hemorrhagic, type 411.3
9telangiectasia, hereditary hemorrhagic, type 311.1
10telangiectasia, hereditary hemorrhagic, type 211.1
11pulmonary arteriovenous malformation11.1
12stoll alembik finck syndrome10.8ACVRL1, ENG
13arteriovenous malformation10.8
14vhl-related pheochromocytoma10.7ACVRL1, ENG, SMAD4
15hepatitis10.7
16eosinophilic meningitis10.6ENG, TGFB1
17glomerulosclerosis, focal segmental, 710.6ENG, SMAD4, TGFB1
18homocystinuria caused by cystathionine beta-synthase deficiency10.6ACVRL1, BMPR2, ENG
19familial mitral valve prolapse10.5BMP6, ENG, VEGFA
20naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis10.5BMP6, TGFB1, VEGFA
21hydromyelia10.5NOS3, VEGFA
22vascular malformation10.5
23chikungunya10.5ENG, VEGFA, VWF
24spinal cord astrocytoma10.4ENG, VEGFA
25strawberry gallbladder10.4BMP6, TGFB1, TGFB2
26preeclampsia/eclampsia 110.4ENG, NOS3, VEGFA
27larynx carcinoma in situ10.4NOS3, VEGFA, VWF
28vitreous abscess10.4TGFB1, TGFB2, VEGFA
29bubonic plague10.4NOS3, TGFB1, VEGFA
30cerebritis10.4
31enamel erosion10.4ACVRL1, ENG, VEGFA, VWF
32paroxysmal nocturnal hemoglobinuria10.4SMAD4, TGFB1, VEGFA
33renal fibrosis10.4NOS3, VEGFA, VWF
34aneurysm10.3
35celiac trunk compression syndrome10.3TGFBR1, TGFBR2
36diamond-blackfan anemia10.3TGFB1, TGFB2
37endotheliitis10.3
38pulmonary venous return anomaly10.3TGFBR1, TGFBR2
39arteriovenous fistula10.3
40pancreatitis10.3
41weber syndrome10.2
42pulmonary hypertension10.2
43adrenal rest tumor10.2NOS3, TGFB1, VEGFA, VWF
44burns10.2CXCL8, TGFB1, VEGFA
45angiodysplasia10.1
46pulmonary hypertension, familial primary, 1, with or without hht10.1
47telangiectasia, hereditary hemorrhagic, type 510.1
48pseudoxanthoma elasticum10.1
49adenosine monophosphate deaminase deficiency erythrocyte type10.1TGFB2, TGFBR1, TGFBR2
50gallbladder papillomatosis10.1PDGFRA, SMAD4, TGFB1, VEGFA

Graphical network of the top 20 diseases related to Hereditary Hemorrhagic Telangiectasia:



Diseases related to hereditary hemorrhagic telangiectasia

Symptoms for Hereditary Hemorrhagic Telangiectasia

About this section

Symptoms:

 52 (show all 34)
  • epistaxis
  • cavernous hemangioma
  • cholelithiasis
  • seizures
  • cirrhosis
  • hepatic failure
  • congestive heart failure
  • pulmonary hypertension
  • subarachnoid hemorrhage
  • pulmonary embolism
  • transient ischemic attack
  • spontaneous hematomas
  • abnormality of the cerebral vasculature
  • visceral angiomatosis
  • intestinal polyposis
  • conjunctival telangiectasia
  • amblyopia
  • nephrolithiasis
  • hematuria
  • cholecystitis
  • cerebral hemorrhage
  • portal hypertension
  • microcytic anemia
  • esophageal varix
  • migraine
  • hemoptysis
  • gastrointestinal hemorrhage
  • venous thrombosis
  • retinal telangiectasia
  • abnormality of cardiovascular system physiology
  • arteriovenous malformation
  • mucosal telangiectasiae
  • teleangiectasia of the skin
  • peripheral arteriovenous fistula

HPO human phenotypes related to Hereditary Hemorrhagic Telangiectasia:

(show all 28)
id Description Frequency HPO Source Accession
1 epistaxis hallmark (90%) HP:0000421
2 telangiectasia of the skin hallmark (90%) HP:0100585
3 cavernous hemangioma typical (50%) HP:0001048
4 portal hypertension typical (50%) HP:0001409
5 microcytic anemia typical (50%) HP:0001935
6 migraine typical (50%) HP:0002076
7 spontaneous hematomas typical (50%) HP:0007420
8 visceral angiomatosis typical (50%) HP:0100761
9 visual impairment occasional (7.5%) HP:0000505
10 conjunctival telangiectasia occasional (7.5%) HP:0000524
11 nephrolithiasis occasional (7.5%) HP:0000787
12 hematuria occasional (7.5%) HP:0000790
13 biliary tract abnormality occasional (7.5%) HP:0001080
14 seizures occasional (7.5%) HP:0001250
15 cirrhosis occasional (7.5%) HP:0001394
16 hepatic failure occasional (7.5%) HP:0001399
17 congestive heart failure occasional (7.5%) HP:0001635
18 abnormality of coagulation occasional (7.5%) HP:0001928
19 esophageal varix occasional (7.5%) HP:0002040
20 pulmonary hypertension occasional (7.5%) HP:0002092
21 hemoptysis occasional (7.5%) HP:0002105
22 pulmonary embolism occasional (7.5%) HP:0002204
23 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
24 cerebral ischemia occasional (7.5%) HP:0002637
25 thrombophlebitis occasional (7.5%) HP:0004418
26 abnormality of the retinal vasculature occasional (7.5%) HP:0008046
27 peripheral arteriovenous fistula occasional (7.5%) HP:0100784
28 intestinal polyposis occasional (7.5%) HP:0200008

UMLS symptoms related to Hereditary Hemorrhagic Telangiectasia:


cyanosis, dyspnea, hematemesis, seizures, clubbing

Drugs & Therapeutics for Hereditary Hemorrhagic Telangiectasia

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Drugs for Hereditary Hemorrhagic Telangiectasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BevacizumabPhase 4, Phase 2, Phase 3, Phase 11938216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
2
MentholPhase 421842216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
3
Tranexamic AcidPhase 3, Phase 22411197-18-85526
Synonyms:
08455_FLUKA
1197-17-7
1197-18-8
1ceb
3-14-00-00868 (Beilstein Handbook Reference)
4-(Aminomethyl)-Cyclohexanecarboxylic Acid
4-(Aminomethyl)cyclohexanecarboxylic acid
4-(aminomethyl)cyclohexane-1-carboxylic acid
857653_ALDRICH
A0236
AB00052260
AB1003647
AC-4687
AC1L1KJH
AC1Q50F3
AC1Q546D
AC1Q5U04
ALBB-006013
AMCA
AMCHA
AMH
AR-1F6595
Acide tranexamique
Acide tranexamique [INN-French]
Acido tranexamico
Acido tranexamico [INN-Spanish]
Acidum tranexamicum
Acidum tranexamicum [INN-Latin]
Amikapron
Amstat
Anvitoff
BAY 3517
BPBio1_000069
BRN 2207452
BSPBio_000061
BSPBio_002837
CAS-1197-18-8
CHEBI:48669
CHEMBL292500
CHEMBL877
CID5526
CL 65336
CL-65336
Carxamin
Cyclocapron
Cyklokapron
Cyklokapron (TN)
D01136
DB00302
DV 79
DV-79
DV79
DivK1c_000655
EINECS 214-818-2
Emorhalt
Exacyl
Frenolyse
HMS1568D03
HMS1921F08
HMS2092P03
HMS502A17
Hexapromin
Hexatron
I04-0993
IDI1_000655
KABI 2161
KBio1_000655
KBio2_001871
KBio2_004439
KBio2_007007
KBio3_002337
KBioGR_000511
 
KBioSS_001871
LS-56611
LS-56612
LT00159441
Mastop
MolPort-001-792-390
MolPort-002-512-008
NCGC00016569-01
NCGC00016569-02
NCGC00016569-03
NCGC00094944-01
NCGC00094944-02
NINDS_000655
NSC 291305
NSC291305
Oprea1_786414
Prestwick0_000171
Prestwick1_000171
Prestwick2_000171
Prestwick3_000171
Prestwick_476
RP 18,429
Rikavarin
Rikavarin (TN)
Rikavarin-S
SPBio_000689
SPBio_001982
SPECTRUM1502026
STK503668
STOCK1N-16183
Spectrum2_000655
Spectrum3_001189
Spectrum4_000046
Spectrum5_001258
Spectrum_001391
Spiramin
Tamcha
Tranex
Tranexamate
Tranexamic acid (JP15/USAN/INN)
Tranexamic acid [USAN:INN:BAN:JAN]
Tranexamic acid cis-form
Tranexamsaeure
Tranexan
Tranexmic acid
Tranhexamic acid
Trans AMCHA
Trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid
Trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid
Trans-p-(Aminomethyl)cyclohexanecarboxylic
Transamin
Transamin (TN)
Transamlon
Trasamlon
UNII-6T84R30KC1
Ugurol
WLN: L6TJ AVQ D1Z -T
cis-4-(Aminomethyl)cyclohexanecarboxylic acid
cis-4-Aminomethylcyclohexane-1-carboxylic acid
cis-AMCHA
t-AMCHA
tranexamic acid
tranexmic acid
trans-1-Aminomethylcyclohexane-4-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-carboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid ester
trans-4-Aminomethylcyclohexane-1-carboxylic acid
trans-4-aminomethylcyclohexane-1-carboxylic acid
trans-Amcha
trans-Tranexamic acid
trans-p-(Aminomethyl)cyclohexanecarboxylic acid
4
RanibizumabPhase 1, Phase 2469347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
5
ThalidomidePhase 2, Phase 1106050-35-15426
Synonyms:
( inverted question mark)-Thalidomide
(+)-Thalidomide
(+-)-N-(2,6-dioxo-3-Piperidyl)phthalimide
(+-)-Thalidomide
(+/-)-THALIDOMIDE
(?)-Thalidomide
(±)-N-(2,6-dioxo-3-piperidyl)phthalimide
(±)-thalidomide
.alpha.-(N-Phthalimido)glutarimide
.alpha.-N-Phthalylglutaramide
.alpha.-Phthalimidoglutarimide
1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline
14088-68-7
2,6-Dioxo-3-phthalimidopiperidine
2,6-dioxo-3-phthalimidopiperidine
3-Phthalimidoglutarimide
50-35-1
731-40-8
AB00052362
AC-917
AC1L1KBZ
AC1Q6FJA
AI3-50606
Algosediv
Asidon 3
Asmadion
Asmaval
BPBio1_000159
BRD-A93255169-001-06-9
BRN 0030233
BSPBio_000143
BSPBio_001156
BSPBio_003330
Bio1_000387
Bio1_000876
Bio1_001365
Bio2_000418
Bio2_000898
Bonbrain
Bonbrrin
C07910
C13H10N2O4
CCRIS 8148
CHEBI:105028
CHEMBL468
CID5426
CPD000058524
Calmore
Calmorex
Celgene Brand of Thalidomide
Contergan
Corronarobetin
D00754
D013792
DB01041
Distaval
Distaxal
Distoval
DivK1c_000051
E-217
EINECS 200-031-1
ENMD 0995
EU-0101224
Ectiluran
Enterosediv
Gastrinide
Glupan
Glutanon
Grippex
HMS1362J17
HMS1568H05
HMS1792J17
HMS1922E12
HMS1990J17
HMS2090O05
HMS2093G15
HMS500C13
HSDB 3586
Hippuzon
I06-0197
IDI1_000051
IDI1_002173
IN1061
Imida-Lab
Imida-lab
Imidan
Imidan (peyta)
Imidene
Isomin
K 17
K-17
KBio1_000051
KBio2_000496
KBio2_002322
KBio2_003064
KBio2_004890
KBio2_005632
KBio2_007458
KBio3_000911
KBio3_000912
KBio3_002550
KBio3_002802
KBioGR_000496
KBioGR_001474
KBioGR_002322
KBioSS_000496
KBioSS_002324
Kedavon
Kevadon
LS-109463
LS-140
Lopac0_001224
Lulamin
MLS000069353
MolPort-003-665-582
N-(2,6-Dioxo-3-piperidyl)phthalimide
N-(2,6-dioxo-3-piperidyl)phthalimide
N-Phthalimidoglutamic acid imide
N-Phthaloylglutamimide
N-Phthalyl-glutaminsaeure-imid
N-Phthalyl-glutaminsaeure-imid [German]
N-Phthalylglutamic acid imide
NCGC00015989-03
NCGC00015989-13
NCGC00024708-02
 
NCGC00024708-03
NCGC00024708-04
NCGC00024708-05
NCGC00024708-06
NCGC00024708-07
NCGC00024708-08
NCGC00024708-09
NCI60_023904
NCIOpen2_003188
NINDS_000051
NSC 527179
NSC-66847
NSC527179
NSC66847
NSC91729
NSC91730
Neaufatin
Neo
Neosedyn
Neosydyn
Nerosedyn
Neufatin
Neurodyn
Neurosedin
Neurosedym
Neurosedyn
Nevrodyn
Nibrol
Noctosediv
Noxodyn
Pangul
Pantosediv
Poly-Giron
Polygripan
Predni-Sediv
Prestwick0_000192
Prestwick1_000192
Prestwick2_000192
Prestwick3_000192
Prestwick_463
Pro-Bam M
Pro-ban M
Profarmil
Psycholiquid
Psychotablets
Quetimid
Quietoplex
S1193_Selleck
SAM002564245
SMR000058524
SPBio_000893
SPBio_002064
SPECTRUM1503607
ST51039042
Sandormin
Sedalis
Sedalis sedi-lab
Sedimide
Sedin
Sedisperil
Sedoval
Shin-naito S
Shinnibrol
Sleepan
Slipro
Softenil
Softenon
Spectrum2_000707
Spectrum3_001715
Spectrum4_001087
Spectrum5_001791
Synovir
T144_SIGMA
T150_SIGMA
T151_SIGMA
THALIDOMIDE (AIDS INITIATIVE)
Talargan
Talidomida
Talidomida [INN-Spanish]
Talidomide
Talidomide [DCIT]
Talimol
Talismol
Talizer
Telagan
Telargan
Telargean
Tensival
Thaled
Thaled (TN)
Thalidomide
Thalidomide (+ and -)
Thalidomide (JAN/USP/INN)
Thalidomide (soluble form)
Thalidomide Celgene
Thalidomide Pharmion
Thalidomide [USAN:INN:BAN]
Thalidomidum
Thalidomidum [INN-Latin]
Thalidomine USP26
Thalin
Thalinette
Thalomid
Thalomid (TM)
Thalomid (TN)
Thalomid, Thalidomide
Thalomide
Theophilcholine
UNII-4Z8R6ORS6L
UPCMLD-DP139
UPCMLD-DP139:001
Valgis
Valgraine
WLN: T56 BVNVJ C- DT6VMVTJ
WLN: T56 BVNVJ C- DT6VMVTJ -D
WLN: T56 BVNVJ C- DT6VMVTJ -L
Yodomin
alpha-(N-Phthalimido)glutarimide
alpha-N-Phthalylglutaramide
alpha-Phthalimidoglutarimide
alpha-phthalimidoglutarimide
cMAP_000022
thalidomide
α-(N-phthalimido)glutarimide
α-N-phthalylglutaramide
α-phthalimidoglutarimide
6
TamoxifenPhase 236810540-29-12733526
Synonyms:
(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC)
(Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE
(Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
,citrate
1-P-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-.beta.-Dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
10540-29-1
1ya4
2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
54965-24-1 (citrate)
AC1MBZ3R
Apo-Tamox
Apo-tamox
BIDD:ER0008
BIDD:GT0009
BIDD:PXR0003
BPBio1_000278
BRD-K93754473-001-02-9
BRD-K93754473-048-05-3
BSPBio_000252
BSPBio_001150
BSPBio_001982
C07108
C26H29NO
CCRIS 3275
CHEBI:41774
CHEMBL83
CID2733526
Citofen
Crisafeno
D08559
DB00675
Diemon
EINECS 234-118-0
Gen-Tamoxifen
Gen-tamoxifen
HMS1362J11
HMS1792J11
HMS1990J11
HMS2090N08
HSDB 6782
ICI 47699
ICI-46,474
ICI-47699
IDI1_000258
IDI1_002170
Istubol
Kessar
L024126
LS-393
Lopac0_001203
MLS001332535
MLS001332536
MolPort-003-850-384
 
NCGC00024928-01
NCGC00024928-03
NCGC00024928-04
NCGC00024928-05
NCGC00024928-07
NCGC00024928-08
NCGC00024928-09
NCGC00024928-12
NSC727681
Noltam
Nolvadex
Nolvadex-D
Nourytam
Novaldex
Novo-Tamoxifen
Oncomox
PMS-Tamoxifen
Pms-Tamoxifen
Prestwick2_000146
Prestwick3_000146
QTL1_000079
Retaxim
SMR000059172
ST50511785
Spectrum5_001417
Spectrum5_002043
T5648_SIGMA
TAMOXIFEN (TAMOXIFEN CITRATE (54965-24-1))
TRANS FORM OF TAMOXIFEN
Tamizam
Tamofen
Tamone
Tamoplex (TN)
Tamoxasta
Tamoxen
Tamoxifen
Tamoxifen (INN)
Tamoxifen (TN)
Tamoxifen (Z)
Tamoxifen Citrate
Tamoxifen [INN:BAN]
Tamoxifen and its salts
Tamoxifene
Tamoxifene [INN-French]
Tamoxifeno
Tamoxifeno [INN-Spanish]
Tamoxifenum
Tamoxifenum [INN-Latin]
Tamoxifène
Tocris-0999
Tomaxithen
Trans-Tamoxifen
UNII-094ZI81Y45
UPCMLD-DP027
Valodex
Zemide
cMAP_000044
nchembio.140-comp7
nchembio.76-comp1
nchembio732-comp3
tamoxifen
trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
trans-Tamoxifen
7
OctreotidePhase 220683150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
 
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
8
SomatostatinPhase 221238916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
9
IronPhase 210807439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro
10
TimololPhase 225126839-75-833624, 5478
Synonyms:
(-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole
(2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
(S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(S)-timolol
131628-37-0
194288-09-0
26839-75-8
26921-17-5 (maleate (1:1) salt)
AB00513729
AC1L1PYN
AC1Q59QM
Apo-Timol
Apo-Timop
Aquanil
BIDD:GT0073
BPBio1_001008
BRD-K08806317-050-03-6
BSPBio_000916
Betim
Betimol
Betimol (TN)
Blocadren
C07141
C13H24N4O3S
CAS-26921-17-5
CHEBI:9599
CHEMBL499
CID33624
CPD001456519
D08600
DB00373
DB08625
EINECS 248-032-6
HMS2089I11
HSDB 6533
Istalol
L-714,465
LS-122231
Lopac-T-6394
Lopac0_001189
MK-950
NCGC00016038-01
 
NCGC00016038-02
NCGC00016798-01
NCGC00016798-07
NCGC00022033-02
NCGC00022033-04
NCGC00022033-05
Novo-Timol
Nu-Timolol
Oprea1_640981
Optimol
Phoxal-timolol
Prestwick0_000948
Prestwick1_000948
Prestwick2_000948
Prestwick3_000948
Proflax
S(-)-Timolol maleate
S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole
SAM002564238
SPBio_003075
ST072193
TIM
Temserin
Tenopt
Tim-AK
Timacar
Timacor
Timolol
Timolol (INN)
Timolol (TN)
Timolol GFS
Timolol Maleate, (1:1) Salt
Timolol [USAN]
Timolol anhydrous
Timolol maleate
Timololo
Timololum
Timololum [INN-Latin]
Timopic
Timoptic
Timoptic OcuDose
Timoptic in Ocudose
Timoptic-XE
Timoptol
Tocris-0649
UNII-817W3C6175
timolol
11
Peginterferon alfa-2bPhase 230299210-65-8, 215647-85-1
Synonyms:
215647-85-1
D02748
PEG-Intron
PegIntron
 
Peginterferon alfa-2b
Peginterferon alfa-2b (INN)
Peginterferon alfa-2b (generical recombination)
Peginterferon alfa-2b (generical recombination) (JAN)
Pegintron (TN)
Unitron PEG
12interferonsPhase 22112
13PomalidomidePhase 111419171-19-8
14
Sodium Tetradecyl Sulfate51191-50-0, 139-88-814492, 5248
Synonyms:
1-Tetradecanol, 1-(hydrogen sulfate), sodium salt (1:1)
1-Tetradecanol, hydrogen sulfate, sodium salt
1191-50-0
22088-37-5
7-Ethyl-2-methyl-4-undecanol sulfate sodium salt
7-ethyl-2-methyl-4-undecanolsulfate, sodium salt
C14H28O5S
CHEMBL541505
CID14492
EINECS 214-737-2
LS-148911
Monotetradecylsulfate sodium salt
Monotetradecylsulphate sodium salt
Myristyl sulfate, sodium salt
NSC 139032
Natri tetradecylsulfas
Natrii tetradecyclis sulfas
Natrii tetradecyclis sulfas [INN-Latin]
Natrii tetradecylis sulfa
Niaproof 4
S.T.D
S.T.D.
STDS
 
STS
Sodium 2-methyl-7-ethylundecanol-4-sulfate
Sodium 7-ethyl-2-methyl-4-undecanol sulfate
Sodium myristyl sulfate
Sodium myristyl sulphate
Sodium tetradecyl sulphate
Sodium tetradecylsulfate
Sotradecol Sodium
Sulfuric acid, monotetradecyl ester, sodium salt
Sulfuric acid, myristyl ester, sodium salt
Tesapon K 14
Tetradecilsulfato sodico
Tetradecilsulfato sodico [INN-Spanish]
Tetradecyl hydrogen sulfate
Tetradecyl hydrogen sulphate
Tetradecyl sodium sulfate
Tetradecyl sodium sulphate
Tetradecyl sulfate
Tetradecyl sulfate de sodium
Tetradecyl sulfate de sodium [INN-French]
Tetradecyl sulfate, sodium salt
Tetradecyl sulfuric Acid
Tetradecyl sulphate
Texapon K 14
Trombavar
15
Methamphetamine216537-46-210836
Synonyms:
(+ )-Methylamphetamine
(+ )-methylamphetamine
(+)-(S)-Deoxyephedrine
(+)-(S)-N-alpha-Dimethylphenethylamine
(+)-(S)-N-alpha-dimethylphenethylamine
(+)-(S)-N-α-dimethylphenethylamine
(+)-(S)-deoxyephedrine
(+)-(s)-deoxyephedrine
(+)-(s)-n-alpha-dimethylphenethylamine
(+)-2-(N-Methylamino)-1-phenylpropane
(+)-Methylamphetamine
(+)-N,alpha-Dimethyl-beta-phenylethylamine
(+)-N,alpha-Dimethylphenethylamine
(+)-N,alpha-dimethyl-beta-phenylethylamine
(+)-N,alpha-dimethylphenethylamine
(+)-N-Methylamphetamine
(+)-N-methylamphetamine
(+)-methamphetamine
(+)-methylamphetamine
(+)-n,alpha-dimethyl-beta-phenylethylamine
(+)-n,alpha-dimethylphenethylamine
(+)-n-methylamphetamine
(2S)-N-methyl-1-phenylpropan-2-amine
(AlphaS)-N,alpha-dimethylbenzeneethanamine
(S)-(+)-Deoxyephedrine
(S)-(+)-Methamphetamine
(S)-(+)-N,alpha,dimethylphenethylamine
(S)-(+)-deoxyephedrine
(S)-(+)-methamphetamine
(S)-Methamphetamine
(S)-Methylamphetamine
(S)-N,alpha-Dimethylbenzeneethanamine
(S)-N,alpha-Dimethylbenzeneethanoamine
(S)-N,alpha-dimethylbenzeneethanamine
(S)-N,alpha-dimethylbenzeneethanoamine
(S)-N,α-dimethylbenzeneethanamine
(S)-methamphetamine
(S)-methylamphetamine
(alphaS)-N,alpha-dimethylbenzeneethanamine
(s)-(+)-deoxyephedrine
(s)-(+)-methamphetamine
(s)-(+)-n,alpha,dimethylphenethylamine
(s)-methamphetamine
(s)-methylamphetamine
(s)-n,alpha-dimethylbenzeneethanamine
(s)-n,alpha-dimethylbenzeneethanoamine
(αS)-N,α-dimethylbenzeneethanamine
1-Phenyl-2-methylamino-propan
1-Phenyl-2-methylamino-propan [German]
1-Phenyl-2-methylaminopropane
139-47-9
14611-50-8
1690-86-4
2S-(+)-Methamphetamine
45952-89-4
537-46-2
AC1L1W1Z
AC1Q4SVR
B40
Benzeneethanamine, N,alpha-dimethyl-, (S)- (9CI)
Benzeneethanamine, N,alpha-dimethyl-, (alphaS)- (9CI)
C07164
C10H15N
CHEBI:6809
CHEMBL1201201
CID10836
Crank
Crank [Street Name]
Crystal Meth
Crystal Meth [Street Name]
D-(S)-Methamphetamine
D-(s)-methamphetamine
D-1-Phenyl-2-methylaminopropan
D-1-Phenyl-2-methylaminopropan [German]
D-1-Phenyl-2-methylaminopropane
D-Deoxyephedrine
D-Desoxyephedrine
D-Methamphetamine
D-Methylamphetamine
D-N,alpha-Dimethylphenethylamine
D-N,alpha-dimethylphenethylamine
D-N-Methylamphetamine
D-Phenylisopropylmethylamine
D-deoxyephedrine
D-desoxyephedrine
D-methamphetamine
D-methylamphetamine
 
D-n,alpha-dimethylphenethylamine
D-n-methylamphetamine
D-phenylisopropylmethylamine
D08187
DB01577
DEA No. 1105
Desoxyephedrine hydrochloride
Desoxyn
Desyphed
Desyphed hydrochloride
Dextromethamphetamine
EINECS 208-668-7
HSDB 3359
ICE [Street Name]
Ice
L-Methamphetamine
L-methamphetamine
LS-103331
METHAMPHETAMINE
Metamfetamina
Metamfetamina [INN-Spanish]
Metamfetamina [inn-spanish]
Metamfetamine
Metamfetamine (INN)
Metamfetamine [INN]
Metamfetamine-m
Metamfetaminum
Metamfetaminum [INN-Latin]
Metamfetaminum [Latin]
Metamfetaminum [inn-latin]
Metamphetamine
Metanfetamina
Metanfetamina [INN-Spanish]
Metanfetamina [Spanish]
Metanfetamina [inn-spanish]
Meth
Meth (Street Name)
Methamphetamine
Methamphetamine, its salts, isomers, and salts of its isomers
Methamphetaminum
Methamphetaminum [INN-Latin]
Methamphetaminum [JP]
Methamphetaminum [inn-latin]
Methyl-.beta.-phenylisopropylamine
Methyl-beta-phenylisopropylamine
Methylamphetamine
MolPort-001-794-405
Métamfétamine
N-Methyl-1-phenyl-2-propanamine
N-Methyl-beta-phenylisopropylamin
N-Methyl-beta-phenylisopropylamin [German]
N-Methyl-beta-phenylisopropylamin [german]
N-Methyl-beta-phenylisopropylamine
N-Methylamphetamine
N-methyl-beta-phenylisopropylamin [german]
N-methyl-beta-phenylisopropylamine
N-methylamphetamine
NSC 25115
NSC25115
Norodin
PDSP1_001404
PDSP1_001405
PDSP2_001388
PDSP2_001389
Phenethylamine, N,alpha-dimethyl-, (S)-(+)- (8CI)
S-(+)-Methamphetamine
S-(+)-methamphetamine
Speed
Speed [Street Name]
Stimulex
UNII-44RAL3456C
WLN: 1MY1&1R -D
d-(S)-Methamphetamine
d-1-Phenyl-2-methylaminopropan [German]
d-1-phenyl-2-methylaminopropane
d-Deoxyephedrine
d-Desoxyephedrine
d-Methamphetamine
d-Methylamphetamine
d-N,.alpha.-Dimethylphenethylamine
d-N-Methylamphetamine
d-N-methylamphetamine
d-Phenylisopropylmethylamine
d-deoxyephedrine
d-desoxyephedrine
d-phenylisopropylmethylamine
desohyephedrine
methyl-β-phenylisopropylamine
16
Sitaxentan23184036-34-8, 210421-64-06478419, 216235
Synonyms:
184036-34-8
AC1L50C3
AC1Q5G7P
AR-1F5297
C106276
CHEBI:123417
CHEMBL282724
CID216235
D07171
DB06268
 
IPI 1040
N-(4-Chloro-3-methyl-5-isoxazolyl)-2-((2-methyl-4,5-methylenedioxyphenyl)acetyl)thiophene-3-sulfonamide
N-(4-Chloro-3-methyl-5-isoxazolyl)-2-((3,4-(methylenedioxy)-6-methylphenyl)acetyl)-3-thiophenesulfonamide
N-(4-chloro-3-methyl-1,2-oxazol-5-yl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide
Sitaxentan
Sitaxentan (INN)
Sitaxsentan
TBC 11251
TBC-11251
TBC11251
Thelin
UNII-J9QH779MEM
17
Bosentan102147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
DB00559
 
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentan
bosentanum
bosentán
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
18
Cocaine47250-36-25760, 446220
Synonyms:
(-)-Cocaine
(-)-Cocaine base
(1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate
(1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl benzoate
(R)-Cocaine
(−)-cocaine
1-Cocaine
1i7z
1q72
2-Methyl-3beta-hydroxy-1alphah,5alphah-tropane-2beta-carboxylate benzoate (ester)
2-beta-Carbomethoxy-3-beta-benzoxytropane
2-beta-Tropanecarboxylic acid, 3-beta-hydroxy-, methyl ester, benzoate (ester)
2beta-Carbomethoxy-3beta-benzoxytropane
3-Tropanylbenzoate-2-carboxylic acid methyl ester
3beta-Hydroxy-2beta-tropanecarboxylic acid methyl ester benzoate (ester)
50-36-2
53-21-4 (hydrochloride)
610089_ALDRICH
610089_FLUKA
AC-16037
AC-20208
AC1L1EK2
AC1L1L2T
AC1L3U2D
AC1L9JBL
Allococaine
Allopseudococaine
Badrock
Bazooka
Benzoylethylecgonine
Benzoylmethylecgonine
Bernice
Bernice [Street Name]
Bernies
Beta-Cocain
Blast
Blizzard
Blow
Blow [Street Name]
Bouncing Powder
Bump
Burese
C" Carrie
C01416
C8912_SIGMA
CHEBI:27958
CID11779748
CID2826
CID446220
CID5760
COC
CPD-9776
Cabello
Candy
Carrie
Caviar
Cecil
Cecil [Street Name]
Charlie
Chicken Scratch
Cholly
Coca
Cocain
Cocaina
Cocaine
Cocaine (TN)
Cocaine (USP)
Cocaine Free Base
Cocaine [BAN]
Cocaine free base
Cocaine solution
Cocaine-M
Cocainum
Cocktail
Coke
Cola
Corine
Crack
Crack cocaine
D-pseudococaine
D00110
DB00907
DEA No. 9041
Dama Blanca
Dama blanca
Delcaine
Depsococaine
Dextrocaine
DivK1c_000975
Dust
EINECS 200-032-7
Ecgonine methyl ester benzoate
Ecgonine methyl ester benzoate solution
Ecgonine, methyl ester, benzoate (ester)
 
Eritroxilina
Erytroxylin
Flake
Flake [Street Name]
Flex
Florida Snow
Foo Foo
Freeze
G-Rock
Girl
Girl [Street Name]
Gold Dust
Gold dust
Gold dust [Street Name]
Goofball
Green Gold
Green gold
HSDB 6469
Happy Dust
Happy Powder
Happy Trails
Happy dust
Happy dust [Street Name]
Happy powder
Happy trails
Heaven
Hell
IDI1_000975
Isocaine
Isococain
Isococaine
Jam
KBio1_000975
Kibbles N' Bits
Kibbles n' Bits
Kokain
Kokan
Kokayeen
L-Cocain
L-Cocaine
L000836
LS-157759
Lady
Lady [Street Name]
Leaf
MLS002320697
Methyl 3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Methyl 3beta-hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylate benzoate (ester)
Methyl Benzoylecgonine
Methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Methyl benzoylecgonine
MolPort-002-535-520
MolPort-003-937-722
Moonrocks
NCGC00159467-02
NINDS_000975
Neurocaine
Nose candy
Pimp's Drug
Pimp's drug
Prime Time
Pseudoallococaine
Pseudococaine
Rock
Rock [Street Name]
SMR001338843
STOCK1N-68258
Sleighride
Snort
Snow
Snow (birds)
Star Dust
Star dust
Star-Spangled Powder
Star-spangled powder
Sugar
Sweet Stuff
Toke
Toot
Toot [Street Name]
Trails
UNII-I5Y540LHVR
White girl or lady
Yeyo
Zip
[1R-(Exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester
beta-Cocain
cocaine
cocainum
d-Pseudococaine
l-Cocain
methyl (1S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
methyl (3S,4R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
methyl 3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
nchembio.284-comp4
19
Maleic acid292110-16-7444266
Synonyms:
(2Z)-2-Butenedioate
(2Z)-2-Butenedioic acid
(2Z)-Butene-2-dioate
(2Z)-Butene-2-dioic acid
(2Z)-but-2-enedioate
(2Z)-but-2-enedioic acid
(Z)-2-Butenedioate
(Z)-2-Butenedioic acid
(z)-butenedioate
(z)-butenedioic acid
2-Butenedioate
2-Butenedioic acid
Cis-butenedioate
Cis-butenedioic acid
 
H2male
Kyselina maleinova
MAE
Maleate
Maleic acid
Maleic acid [NA2215]
Maleinic acid
Malenic acid
Malezid CM
Scotchbond multipurpose etchant
Toxilic acid
cis-1,2-Ethylenedicarboxylic acid
cis-2-Butenedioate
cis-2-Butenedioic acid
cis-But-2-enedioate
cis-But-2-enedioic acid
20
Lidocaine1168137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide

Interventional clinical trials:

(show all 48)
idNameStatusNCT IDPhase
1Investigation of Coagulation Parameters in Hereditary Haemorrhagic TelangiectasiaCompletedNCT00230659Phase 4
2Intranasal Bevacizumab for HHT-Related EpistaxisRecruitingNCT02389959Phase 4
3Tranexamic Acid and Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)CompletedNCT01031992Phase 3
4Phase III Randomized, Placebo-Controlled, Crossover Study of Soy Protein Isolate for Hereditary Hemorrhagic TelangiectasiaCompletedNCT00004654Phase 3
5ATERO : A Randomised Study With Tranexamic Acid in Epistaxis of Rendu Osler SyndromeCompletedNCT00355108Phase 3
6Efficacy of a Bevacizumab Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)TerminatedNCT02106520Phase 2, Phase 3
7Phase II Pilot Study of Octreotide, a Somatostatin Octapeptide Analog, for Gastrointestinal Hemorrhage in Hormone-Refractory Hereditary Hemorrhagic Telangiectasia and Senile EctasiaCompletedNCT00004327Phase 2
8Intranasal Submucosal Bevacizumab for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)CompletedNCT01314274Phase 2
9Anti-Estrogen Therapy for Hereditary Hemorrhagic Telangiectasia A Double-Blind Placebo-Controlled Clinical TrialCompletedNCT00375622Phase 2
10Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal BleedingCompletedNCT00389935Phase 2
11North American Study of Epistaxis in HHTCompletedNCT01408030Phase 2
12Efficacy and Safety of Bevacizumab for the Treatment Hemorrhagic Hereditary Telangiectasia (HHT) Associated With Severe Hepatic Vascular Malformations. Phase II StudyCompletedNCT00843440Phase 2
13Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related MaculopathyCompletedNCT00470977Phase 1, Phase 2
14Submucosal Bevacizumab for the Management of Recurrent Epistaxis in Patients With Hereditary Hemorrhagic Telangiectasia (HHT)RecruitingNCT01402531Phase 2
15Topical Bevacizumab for the Management of Recurrent Epistaxis in Patients With Hereditary Hemorrhagic Telangiectasia (HHT)RecruitingNCT01397695Phase 2
16Efficacy of a Timolol Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) - Randomized Trial Versus PlaceboRecruitingNCT02484716Phase 2
17Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective DoseRecruitingNCT02157987Phase 1, Phase 2
18Evaluation of Pazopanib on Bleeding in Subjects With Hereditary Haemorrhagic TelangiectasiaRecruitingNCT02204371Phase 2
19Efficacy of Thalidomide in the Treatment of Hereditary Hemorrhagic TelangiectasiaActive, not recruitingNCT01485224Phase 2
20Octreotide in Patients With GI Bleeding Due to Rendu-Osler-WeberNot yet recruitingNCT02874326Phase 2
21Phase 2 Study of PEG-Intron in Hereditary Hemorrhagic TelangiectasiaTerminatedNCT00588146Phase 2
22The ELLIPSE Study: A Phase-1 Study Evaluating the Tolerance of Bevacizumab Nasal Spray to Treat Epistaxis in Hereditary Hemorrhagic TelangiectasiaCompletedNCT01507480Phase 1
23Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I StudyNot yet recruitingNCT02287558Phase 1
24Ranibizumab for the Management of Recurrent Nosebleeds in Patients With Hereditary Hemorrhagic Telangiectasia (HHT)WithdrawnNCT01406639Phase 1
25Office-sclerotherapy for Epistaxis Due to Hereditary Hemorrhagic TelangiectasiaCompletedNCT01408732
26Screening Behavior in Adults With Hereditary Hemorrhagic TelangiectasiaCompletedNCT00684879
27Studies of Hereditary Hemorrhagic TelangiectasiaCompletedNCT00004648
28Study of the Natural History and Genotype-Phenotype Correlations of Hereditary Hemorrhagic Telangiectasia PatientsCompletedNCT00004649
29Frequency of Common Medical Conditions in People With and Without HHTCompletedNCT02464644
30Hereditary Haemorrhagic Telangiectasia Flight Safety StudyCompletedNCT01590121
31Cerebral Hemorrhage Risk in Hereditary Hemorrhagic TelangiectasiaRecruitingNCT01158807
32Symptoms and Treatment Results in Hereditary Hemorrhagic TelangiectasiaRecruitingNCT02690246
33Topical Anti-angiogenic Therapy for Telangiectasia in HHT: Proof of ConceptRecruitingNCT01752049
34Iron Deficiency and Hereditary Haemorrhagic TelangiectasiaRecruitingNCT01908543
35Molecular Studies on Hereditary Haemorrhagic Telangiectasia FamiliesRecruitingNCT00230620
36Case Notes Review on Patients With Hereditary Haemorrhagic TelangiectasiaRecruitingNCT00230685
37Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMsRecruitingNCT02436213
38Investigation of Plasma Proteins in Patients With Hereditary Haemorrhagic Telangiectasia and PAVMsRecruitingNCT00230672
39Reperfusion of Pulmonary Arteriovenous Malformations After EmbolotherapyRecruitingNCT01856842
40Institutional Registry of Haemorrhagic Hereditary TelangiectasiaRecruitingNCT01761981
41Studies of White Blood Cells Derived From HHT PatientsRecruitingNCT00230633
42Registry for Vascular Anomalies Associated With CoagulopathyRecruitingNCT00576888
43Pharmacogenomics in Pulmonary Arterial HypertensionRecruitingNCT00593905
44Diet and Hereditary Haemorrhagic TelangiectasiaActive, not recruitingNCT01692015
45Study of Histological Samples From Patients With Hereditary Haemorrhagic TelangiectasiaActive, not recruitingNCT00733655
46Study of Endothelial Cells in Patients With Hereditary Haemorrhagic TelangiectasiaActive, not recruitingNCT00733629
47Prospective Pilot Study of Floseal for the Treatment of Anterior Epistaxis in Patients With (HHT)Not yet recruitingNCT02638012
48Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs With and Without Airflow ObstructionNot yet recruitingNCT02458703

Search NIH Clinical Center for Hereditary Hemorrhagic Telangiectasia


Cochrane evidence based reviews: telangiectasia, hereditary hemorrhagic

Genetic Tests for Hereditary Hemorrhagic Telangiectasia

About this section

Genetic tests related to Hereditary Hemorrhagic Telangiectasia:

id Genetic test Affiliating Genes
1 Osler Hemorrhagic Telangiectasia Syndrome25
2 Hereditary Hemorrhagic Telangiectasia23 SMAD4

Anatomical Context for Hereditary Hemorrhagic Telangiectasia

About this section

MalaCards organs/tissues related to Hereditary Hemorrhagic Telangiectasia:

34
Liver, Skin, Brain, Lung, Testes, Endothelial, Heart

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Hereditary Hemorrhagic Telangiectasia:
id TissueAnatomical CompartmentCell Relevance
1 Lateral Plate MesodermSplanchnic MesodermMural Cells Potential therapeutic candidate

Animal Models for Hereditary Hemorrhagic Telangiectasia or affiliated genes

About this section

MGI Mouse Phenotypes related to Hereditary Hemorrhagic Telangiectasia:

39 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.1ACVRL1, NOS3, SMAD4, SP1, TGFB1, TGFBR2
2MP:00020068.6PDGFRA, SMAD1, SMAD4, TGFB1, TGFBR1, TGFBR2
3MP:00053678.3ACVRL1, BMPR2, NOS3, PDGFRA, SMAD4, TGFB1
4MP:00053717.9NOS3, PDGFRA, SMAD4, SP1, TFAP2A, TGFB2
5MP:00107717.7ANGPT2, COL5A1, ENG, PDGFRA, SMAD4, SP1
6MP:00053797.5NOS3, PDGFRA, SMAD1, SMAD4, TFAP2A, TGFB1
7MP:00053917.4ANGPT2, COL5A1, GDF2, NOS3, SP1, TFAP2A
8MP:00053697.4ACVRL1, BMPR2, ENG, NOS3, PDGFRA, SMAD1
9MP:00053827.2ACVRL1, ENG, PDGFRA, SMAD1, SMAD4, SP1
10MP:00028737.0ACVRL1, BMPR2, COL5A1, ENG, NOS3, PDGFRA
11MP:00053876.9ANGPT2, BMPR2, GDF2, NOS3, PDGFRA, SMAD4
12MP:00053886.6ACVRL1, ANGPT2, BMPR2, ENG, NOS3, PDGFRA
13MP:00053846.6ANGPT2, BMPR2, NOS3, PDGFRA, SMAD1, SMAD4
14MP:00053976.4ACVRL1, BMPR2, ENG, NOS3, PDGFRA, SMAD4
15MP:00053816.4ACVRL1, ANGPT2, ENG, NOS3, PDGFRA, SMAD1
16MP:00036316.4ACVRL1, BMPR2, ENG, NOS3, PDGFRA, SMAD1
17MP:00053806.3ACVRL1, BMPR2, COL5A1, ENG, PDGFRA, SMAD1
18MP:00053765.9ACVRL1, ANGPT2, BMPR2, ENG, NOS3, PDGFRA
19MP:00053905.8BMP6, BMPR2, GDF2, NOS3, PDGFRA, SMAD1
20MP:00053785.4ACVRL1, BMP6, BMPR2, COL5A1, ENG, NOS3
21MP:00107685.2ACVRL1, ANGPT2, BMPR2, COL5A1, ENG, NOS3
22MP:00053855.0ACVRL1, ANGPT2, BMPR2, COL5A1, ENG, GDF2

Publications for Hereditary Hemorrhagic Telangiectasia

About this section

Articles related to Hereditary Hemorrhagic Telangiectasia:

(show top 50)    (show all 616)
idTitleAuthorsYear
1
Free-flap reconstruction for the management of life-threatening hereditary hemorrhagic telangiectasia. (27616747)
2016
2
Effect of systemic bevacizumab in severe hereditary hemorrhagic telangiectasia associated with bleeding. (26994402)
2016
3
Hemorrhage Rates From Brain Arteriovenous Malformation in Patients With Hereditary Hemorrhagic Telangiectasia. (25858236)
2015
4
Anti-angiogenic therapeutic strategies in hereditary hemorrhagic telangiectasia. (25717337)
2015
5
Lower Risk of Intracranial Arteriovenous Malformation Hemorrhage in Patients With Hereditary Hemorrhagic Telangiectasia. (26540357)
2015
6
An evaluation of the severity and progression of epistaxis in hereditary hemorrhagic telangiectasia 1 versus hereditary hemorrhagic telangiectasia 2. (26372311)
2015
7
Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges. (25741358)
2015
8
A giant pulmonary arteriovenous malformation without hereditary hemorrhagic telangiectasia: successful interventional embolization using a PDA occluder. (24627323)
2014
9
Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome in an adolescent with complex chromosomal rearrangement and intellectual disability. (25081192)
2014
10
Brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia: clinical presentation and anatomical distribution. (24080277)
2013
11
Successful treatment of thalidomide for recurrent bleeding due to gastric angiodysplasia in hereditary hemorrhagic telangiectasia. (23661527)
2013
12
Two juvenile polyps, hereditary hemorrhagic telangiectasia and SMAD4 mutation. (23794345)
2013
13
High prevalence of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia. (23246127)
2013
14
Elevated circulating microRNA-210 levels in patients with hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations: a potential new biomarker. (23051042)
2013
15
Pancreatic vascular tumor or AVM? Utility of EUS in the diagnosis of hereditary hemorrhagic telangiectasia. (24360031)
2013
16
Management of Pulmonary Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia Patients. (24436569)
2013
17
Hereditary Hemorrhagic Telangiectasia: Breakpoint Characterization of a Novel Large Deletion in ACVRL1 Suggests the Causing Mechanism. (23653583)
2013
18
Spinal arteriovenous fistulas in children with hereditary hemorrhagic telangiectasia. (22656258)
2012
19
Cost savings through molecular diagnosis for hereditary hemorrhagic telangiectasia. (22281938)
2012
20
Liver involvement in hereditary hemorrhagic telangiectasia: can breath test unmask impaired hepatic first-pass effect? (21305365)
2012
21
Juvenile polyposis, hereditary hemorrhagic telangiectasia, and early onset colorectal cancer in patients with SMAD4 mutation. (22331366)
2012
22
Hepatic and pancreatic involvement in hereditary hemorrhagic telangiectasia: quantitative and qualitative evaluation with 64-section CT in asymptomatic adult patients. (21861188)
2012
23
Symptomatic liver involvement in neonatal hereditary hemorrhagic telangiectasia. (21536610)
2011
24
Unsuspected polymicrobial brain abscess arising from an intra-abdominal source in a patient with hereditary hemorrhagic telangiectasia. (20622729)
2010
25
Hereditary hemorrhagic telangiectasia in a patient with microscopic polyangiitis. (19640374)
2009
26
Anesthetic implications for the parturient with hereditary hemorrhagic telangiectasia. (19330398)
2009
27
Impact of genotype and mutation type on health-related quality of life in patients with hereditary hemorrhagic telangiectasia. (18855162)
2009
28
More on bevacizumab in hereditary hemorrhagic telangiectasia. (19714790)
2009
29
Hereditary hemorrhagic telangiectasia: fatigue and dyspnea. (19364795)
2009
30
Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia. (19805914)
2009
31
Antiestrogen therapy for hereditary hemorrhagic telangiectasia: a double-blind placebo-controlled clinical trial. (19160429)
2009
32
Diffuse pulmonary arteriovenous malformations in hereditary hemorrhagic telangiectasia: long-term results of embolization according to the extent of lung involvement. (19118276)
2009
33
Hepatic vascular malformations in hereditary hemorrhagic telangiectasia: in search of predictors of significant disease. (18972437)
2008
34
Genotype-phenotype relationship for localization and age distribution of telangiectases in hereditary hemorrhagic telangiectasia. (18831062)
2008
35
Hereditary hemorrhagic telangiectasia: from epistaxis to life-threatening GI bleeding. (17724405)
2007
36
Analysis of angiogenesis related proteins and its implication in type-2 hereditary hemorrhagic telangiectasia]. (17278429)
2006
37
Acute visual loss as the presenting complaint of hereditary hemorrhagic telangiectasia. (17090798)
2006
38
Ablation of T-helper 1 cell derived cytokines and of monocyte-derived tumor necrosis factor-alpha in hereditary hemorrhagic telangiectasia: immunological consequences and clinical considerations. (16611101)
2006
39
Magnetic resonance (MR) imaging and MR angiography for evaluation and follow-up of hepatic artery banding in patients with hepatic involvement of hereditary hemorrhagic telangiectasia. (16465571)
2006
40
New classification of nasal vasculature patterns in hereditary hemorrhagic telangiectasia. (16539301)
2006
41
Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor-beta1 as well as high ALK1 tissue expression. (15951295)
2005
42
Hereditary hemorrhagic telangiectasia in children: endovascular treatment of neurovascular malformations: results in 31 patients. (16163493)
2005
43
Hereditary hemorrhagic telangiectasia. (16403391)
2005
44
Liver transplantation for cardiac failure in patients with hereditary hemorrhagic telangiectasia. (15973723)
2005
45
Embolization of a duodenal arteriovenous malformation in hereditary hemorrhagic telangiectasia: case report and review of the literature. (14631462)
2003
46
Gastrointestinal: hereditary hemorrhagic telangiectasia. (12702055)
2003
47
A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2. (12588795)
2003
48
The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2. (9245985)
1997
49
COL5A1: fine genetic mapping and exclusion as candidate gene in families with nail-patella syndrome, tuberous sclerosis 1, hereditary hemorrhagic telangiectasia, and Ehlers-Danlos Syndrome type II. (7759113)
1995
50
Endoscopic appearance of gastric angiodysplasia in hereditary hemorrhagic telangiectasia. (6967258)
1980

Variations for Hereditary Hemorrhagic Telangiectasia

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Expression for genes affiliated with Hereditary Hemorrhagic Telangiectasia

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Search GEO for disease gene expression data for Hereditary Hemorrhagic Telangiectasia.

Pathways for genes affiliated with Hereditary Hemorrhagic Telangiectasia

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Pathways related to Hereditary Hemorrhagic Telangiectasia according to GeneCards Suite gene sharing:

(show top 50)    (show all 67)
idSuper pathwaysScoreTop Affiliating Genes
19.7SMAD4, TGFBR1, TGFBR2
29.6BMPR2, SMAD1, SMAD4
39.6BMPR2, SMAD1, SMAD4
4
Show member pathways
9.5SMAD4, TGFB1, TGFBR1, TGFBR2
59.5SMAD4, TGFB1, TGFBR1, TGFBR2
6
Show member pathways
9.5SMAD4, TGFB1, TGFBR1, TGFBR2
79.4TGFB1, TGFBR1, TGFBR2, VEGFA
89.3BMPR2, SMAD1, SMAD4, VEGFA
99.3TGFB1, TGFB2, TGFBR1, TGFBR2
109.3ENG, SMAD4, SP1, VEGFA
119.3BMP6, ENG, TGFB1, TGFB2
129.2BMP6, TGFB1, TGFB2, VEGFA
13
Show member pathways
9.2BMP6, BMPR2, SMAD1, SMAD4
14
Show member pathways
9.1SMAD4, TGFB1, TGFB2, TGFBR1, TGFBR2
15
Show member pathways
9.1SMAD4, TGFB1, TGFB2, TGFBR1, TGFBR2
169.1TGFB1, TGFB2, TGFBR1, TGFBR2, VEGFA
17
Show member pathways
9.0SMAD4, SP1, TGFB1, TGFBR1, TGFBR2
189.0SMAD4, SP1, TGFB1, TGFBR1, TGFBR2
198.9NOS3, SP1, TFAP2A, TGFB1
208.9SMAD4, TGFB1, TGFB2, TGFBR1, TGFBR2, VEGFA
21
Show member pathways
8.9SMAD4, TGFB1, TGFB2, TGFBR1, TGFBR2, VEGFA
22
Show member pathways
8.9NOS3, PDGFRA, SMAD1, VEGFA
238.9ENG, SMAD1, SMAD4, TGFB1, TGFBR1, TGFBR2
248.8CXCL8, TGFB1, TGFB2, VEGFA
258.7ACVRL1, BMP6, BMPR2, SMAD1, SMAD4, VEGFA
26
Show member pathways
8.7CXCL8, SMAD4, TGFB1, TGFBR1, TGFBR2
27
Show member pathways
8.7SMAD1, SMAD4, TGFB1, TGFB2, TGFBR1, TGFBR2
28
Show member pathways
8.6SMAD4, SP1, TGFB1, TGFB2, TGFBR1, TGFBR2
298.5PDGFRA, SMAD4, TGFB1, TGFB2, TGFBR1, TGFBR2
308.5BMP6, SMAD4, TGFB1, TGFB2, TGFBR1, TGFBR2
318.4PDGFRA, SMAD4, SP1, TGFB1, TGFBR1, VEGFA
32
Show member pathways
8.4ACVRL1, BMPR2, GDF2, SMAD1, SMAD4, TGFB1
33
Show member pathways
8.3ACVRL1, BMPR2, ENG, GDF2, SMAD4, TGFB1
348.3ACVRL1, ENG, SMAD1, SMAD4, TGFB1, TGFB2
358.3BMPR2, SMAD1, SMAD4, SP1, TGFBR1, TGFBR2
368.2ACVRL1, ENG, SMAD4, SP1, TGFB1, TGFB2
378.0BMP6, BMPR2, SMAD1, SMAD4, TGFB1, TGFB2
38
Show member pathways
7.9ANGPT2, ENG, NOS3, PDGFRA, TGFB1, TGFB2
39
Show member pathways
7.8BMPR2, PDGFRA, SMAD1, SMAD4, TGFB1, TGFB2
407.8CXCL8, NOS3, SMAD4, TGFB1, TGFB2, TGFBR1
417.6BMP6, BMPR2, ENG, SMAD1, SMAD4, SP1
42
Show member pathways
7.5BMP6, BMPR2, SMAD1, SMAD4, SP1, TGFB1
437.4CXCL8, PDGFRA, SMAD4, TGFB1, TGFB2, TGFBR1
44
Show member pathways
6.9ANGPT2, BMP6, CXCL8, GDF2, SMAD1, SMAD4
45
Show member pathways
6.9BMP6, GDF2, NOS3, PDGFRA, SMAD4, SP1
46
Show member pathways
6.3ACVRL1, ANGPT2, BMP6, BMPR2, CXCL8, GDF2
47
Show member pathways
6.0ACVRL1, ANGPT2, BMP6, BMPR2, CXCL8, GDF2
48
Show member pathways
6.0ACVRL1, ANGPT2, BMP6, BMPR2, CXCL8, NOS3
49
Show member pathways
5.5ANGPT2, BMP6, CXCL8, GDF2, PDGFRA, SMAD1
50
Show member pathways
5.3ACVRL1, ANGPT2, BMP6, BMPR2, COL5A1, CXCL8

GO Terms for genes affiliated with Hereditary Hemorrhagic Telangiectasia

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Cellular components related to Hereditary Hemorrhagic Telangiectasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1SMAD protein complexGO:007114110.6SMAD1, SMAD4
2transforming growth factor beta receptor homodimeric complexGO:007002210.2ENG, TGFBR1, TGFBR2
3platelet alpha granule lumenGO:00310939.9TGFB1, TGFB2, VEGFA, VWF
4caveolaGO:00059019.7BMPR2, NOS3, TGFBR2
5cell surfaceGO:00099868.5ACVRL1, BMPR2, ENG, TGFB1, TGFBR1, TGFBR2
6extracellular spaceGO:00056157.4ANGPT2, BMP6, BMPR2, CXCL8, ENG, GDF2

Biological processes related to Hereditary Hemorrhagic Telangiectasia according to GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of endothelial cell proliferationGO:000193710.5ACVRL1, GDF2, TGFBR1
2artery morphogenesisGO:004884410.4ENG, TGFBR1, VEGFA
3endocardial cushion morphogenesisGO:000320310.4ACVRL1, ENG, TGFB2
4neuron fate commitmentGO:004866310.3SMAD4, TGFB2, TGFBR1
5response to cholesterolGO:007072310.3TGFB1, TGFBR1, TGFBR2
6regulation of transforming growth factor beta receptor signaling pathwayGO:001701510.3ENG, SMAD4, TGFB1
7SMAD protein complex assemblyGO:000718310.3SMAD1, SMAD4, TGFB1
8activin receptor signaling pathwayGO:003292410.3ACVRL1, BMPR2, GDF2, TGFBR1
9negative regulation of DNA biosynthetic processGO:200027910.3ACVRL1, BMPR2, GDF2
10growthGO:004000710.2BMP6, GDF2, VEGFA
11blood vessel morphogenesisGO:004851410.2ACVRL1, ANGPT2, GDF2
12positive regulation of endothelial cell differentiationGO:004560310.2ACVRL1, BMP6, GDF2
13positive regulation of cartilage developmentGO:006103610.1BMPR2, GDF2, SMAD1
14positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formationGO:190500710.1ENG, TGFB2, TGFBR1, TGFBR2
15ventricular trabecula myocardium morphogenesisGO:000322210.1ENG, TGFB2, TGFBR1
16vasculogenesisGO:000157010.0ENG, GDF2, TGFBR2, VEGFA
17positive regulation of BMP signaling pathwayGO:003051310.0ACVRL1, BMPR2, ENG, GDF2, SMAD4
18ventricular septum morphogenesisGO:006041210.0SMAD4, TGFB2, TGFBR1, TGFBR2
19positive regulation of SMAD protein import into nucleusGO:00603919.9BMP6, SMAD4, TGFB1, TGFBR1
20patterning of blood vesselsGO:00015699.9ENG, GDF2, TGFBR2, VEGFA
21negative regulation of blood vessel endothelial cell migrationGO:00435379.9ACVRL1, ANGPT2, GDF2, TGFB1
22retina vasculature development in camera-type eyeGO:00612989.9ACVRL1, BMPR2, PDGFRA
23platelet degranulationGO:00025769.9TGFB1, TGFB2, VEGFA, VWF
24pathway-restricted SMAD protein phosphorylationGO:00603899.8GDF2, TGFB1, TGFB2, TGFBR1, TGFBR2
25blood vessel remodelingGO:00019749.8ACVRL1, BMPR2, NOS3, TGFB2
26signal transduction by protein phosphorylationGO:00230149.8ACVRL1, BMPR2, TGFB2, TGFBR1, TGFBR2
27positive regulation of bone mineralizationGO:00305019.7BMP6, BMPR2, TFAP2A, TGFB1
28positive regulation of epithelial to mesenchymal transitionGO:00107189.7SMAD4, TGFB1, TGFB2, TGFBR1, TGFBR2
29in utero embryonic developmentGO:00017019.5ACVRL1, NOS3, SMAD4, TGFBR1, TGFBR2, VEGFA
30positive regulation of endothelial cell proliferationGO:00019389.5ACVRL1, BMP6, BMPR2, GDF2, TGFBR1, VEGFA
31palate developmentGO:00600219.5SMAD4, TFAP2A, TGFBR1, TGFBR2
32positive regulation of osteoblast differentiationGO:00456699.5BMP6, BMPR2, GDF2, SMAD1
33negative regulation of cell growthGO:00303089.5ACVRL1, BMPR2, GDF2, SMAD4, TGFB1, TGFB2
34cartilage developmentGO:00512169.5BMP6, GDF2, SMAD1, TGFBR2
35kidney developmentGO:00018229.3BMP6, SMAD4, TFAP2A, TGFBR1, VEGFA
36SMAD protein signal transductionGO:00603959.2BMP6, GDF2, SMAD1, SMAD4, TGFB1, TGFB2
37embryonic cranial skeleton morphogenesisGO:00487019.2PDGFRA, TFAP2A, TGFBR1, TGFBR2
38cellular response to BMP stimulusGO:00717739.1ACVRL1, BMP6, BMPR2, GDF2, SMAD1, SMAD4
39transforming growth factor beta receptor signaling pathwayGO:00071799.1ACVRL1, SMAD1, SMAD4, TGFB1, TGFB2, TGFBR1
40BMP signaling pathwayGO:00305098.9ACVRL1, BMP6, BMPR2, ENG, GDF2, SMAD1
41positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108628.7ACVRL1, BMP6, BMPR2, ENG, GDF2, SMAD4
42wound healingGO:00420608.7PDGFRA, TGFB1, TGFB2, TGFBR1, TGFBR2
43positive regulation of transcription, DNA-templatedGO:00458938.7ACVRL1, GDF2, SMAD4, SP1, TFAP2A, TGFB1
44protein phosphorylationGO:00064688.7ACVRL1, BMPR2, SMAD1, TGFB1, TGFB2, TGFBR1
45response to hypoxiaGO:00016668.5ACVRL1, ANGPT2, SMAD4, TGFB1, TGFB2, TGFBR2
46positive regulation of gene expressionGO:00106288.5ENG, GDF2, SMAD1, TFAP2A, TGFB1, TGFB2
47positive regulation of angiogenesisGO:00457668.3ACVRL1, ANGPT2, CXCL8, ENG, GDF2, NOS3
48angiogenesisGO:00015258.0ACVRL1, ANGPT2, CXCL8, ENG, GDF2, NOS3
49negative regulation of cell proliferationGO:00082857.2ACVRL1, CXCL8, NOS3, SMAD1, SMAD4, TFAP2A
50positive regulation of transcription from RNA polymerase II promoterGO:00459446.8ACVRL1, BMP6, BMPR2, ENG, GDF2, SMAD1

Molecular functions related to Hereditary Hemorrhagic Telangiectasia according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1activin bindingGO:004818510.9ACVRL1, ENG
2BMP receptor activityGO:009882110.8ACVRL1, BMPR2
3transforming growth factor beta receptor activity, type IGO:000502510.8ACVRL1, TGFBR1
4BMP bindingGO:003612210.8BMPR2, ENG
5type III transforming growth factor beta receptor bindingGO:003471410.7TGFB1, TGFB2
6type I transforming growth factor beta receptor bindingGO:003471310.5ENG, TGFB1, TGFBR2
7transforming growth factor beta-activated receptor activityGO:000502410.5ACVRL1, TGFBR1, TGFBR2
8transmembrane receptor protein serine/threonine kinase activityGO:000467510.4ACVRL1, BMPR2, TGFBR2
9SMAD bindingGO:004633210.3ACVRL1, TGFBR1, TGFBR2
10platelet-derived growth factor bindingGO:004840710.2COL5A1, PDGFRA
11I-SMAD bindingGO:007041110.2SMAD1, SMAD4, TGFBR1
12transforming growth factor beta bindingGO:005043110.2ACVRL1, ENG, TGFBR1, TGFBR2
13type II transforming growth factor beta receptor bindingGO:000511410.2ENG, TGFB1, TGFB2, TGFBR1
14transforming growth factor beta receptor bindingGO:000516010.0BMP6, GDF2, TGFB1, TGFB2
15receptor signaling protein serine/threonine kinase activityGO:00047029.8ACVRL1, BMPR2, TGFB2, TGFBR1, TGFBR2
16cytokine activityGO:00051259.6BMP6, GDF2, TGFB1, TGFB2, VEGFA
17growth factor activityGO:00080839.6BMP6, GDF2, TGFB1, TGFB2, VEGFA
18protein heterodimerization activityGO:00469828.7BMP6, SMAD1, SMAD4, TGFB1, TGFB2, VEGFA
19metal ion bindingGO:00468728.0ACVRL1, ANGPT2, BMPR2, COL5A1, SMAD1, SMAD4
20protein homodimerization activityGO:00428037.0ENG, PDGFRA, SMAD1, SMAD4, SP1, TFAP2A
21protein bindingGO:00055153.5ACVRL1, ANGPT2, BMP6, BMPR2, COL5A1, CXCL8

Sources for Hereditary Hemorrhagic Telangiectasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet