HNPP
MCID: HRD025
MIFTS: 23

Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) malady

Neuronal, Genetic categories

Summaries for Hereditary Neuropathy with Liability to Pressure Palsies

Sources:
21Genetics Home Reference, 19GeneReviews, 33MalaCards
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Genetics Home Reference:21 Hereditary neuropathy with liability to pressure palsies is a disorder that affects peripheral nerves. These nerves connect the brain and spinal cord to muscles as well as sensory cells that detect touch, pain, and temperature. In people with this disorder, the peripheral nerves are unusually sensitive to pressure.

MalaCards: Hereditary Neuropathy with Liability to Pressure Palsies, also known as tomaculous neuropathy, is related to tooth disease and hereditary neuropathies. An important gene associated with Hereditary Neuropathy with Liability to Pressure Palsies is PMP22 (peripheral myelin protein 22), and among its related pathways is Neural Crest Differentiation. The compounds ganglioside and dihydroprogesterone have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord.

GeneReviews summary for hnpp

Aliases & Classifications for Hereditary Neuropathy with Liability to Pressure Palsies

Sources:
21Genetics Home Reference, 64Wikipedia, 19GeneReviews, 20GeneTests, 45Novoseek, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Neuronal


Aliases & Descriptions:

hereditary neuropathy with liability to pressure palsies 64 19 20 21
tomaculous neuropathy 64 19 21 45
hnpp 64 19 21
hereditary pressure sensitive neuropathy 19 21
inherited tendency to pressure palsies 64 21
compression neuropathy 64 21
entrapment neuropathy 64 21
hereditary motor and sensory neuropathies 61
hereditary liability to pressure palsies 61
hereditary motor and sensory neuropathy 21
familial pressure-sensitive neuropathy 64
familial pressure sensitive neuropathy 21
entrapment neuropathies 61


Related Diseases for Hereditary Neuropathy with Liability to Pressure Palsies

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17GeneCards, 18GeneDecks
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Diseases in the Hereditary Neuropathy with Liability to Pressure Palsies family:

hereditary neuropathy with liability to pressure palsy hereditary type 1 neuropathy
hereditary type 2 neuropathy

Diseases related to Hereditary Neuropathy with Liability to Pressure Palsies via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1tooth disease31.5MPZ, PMP22, GJB1
2hereditary neuropathies31.1PMP22, MPZ, GJB1
3brachial plexus neuropathy31.0PMP22, MPZ
4carpal tunnel syndrome31.0PMP22
5hereditary neuralgic amyotrophy31.0SEPT9
6motor peripheral neuropathy30.9PMP22, MPZ
7pelizaeus-merzbacher disease30.7MPZ
8charcot-marie-tooth neuropathy type 130.7PMP22, MPZ
9chronic inflammatory demyelinating polyradiculoneuropathy30.7MPZ, PMP22
10charcot-marie-tooth disease type 330.6MPZ, GJB1, PMP22
11charcot-marie-tooth neuropathy type 230.4MPZ
12sensory peripheral neuropathy30.4PMP22, MPZ, GJB1
13charcot-marie-tooth hereditary neuropathy11.2
14chromosome 17p deletion10.8
15hereditary neuropathy with liability to pressure palsy10.8
16n syndrome10.7
17hereditary motor and sensory neuropathy with agenesis of the corpus callosum10.7
18charcot-marie-tooth disease with pyramidal features, autosomal dominant10.7
19hereditary motor and sensory neuropathy vi10.7
20lateral sclerosis10.6
21peroneal neuropathy10.6
22amyotrophic lateral sclerosis10.6
23foot drop10.6
24corpus callosum agenesis10.6
25charcot-marie-tooth disease type 2c10.6
26neuropathy, hereditary motor and sensory, okinawa type10.6
27hereditary spastic paraplegia10.5
28neuropathy, hereditary motor and sensory, russe type10.5
29axonal neuropathy10.5
30median neuropathy10.5
31oculopharyngeal muscular dystrophy10.5
32autosomal dominant disease10.5
33autosomal recessive disease10.5
34amyloid neuropathy10.5
35hereditary type 1 neuropathy10.5
36myoclonus10.5
37neuropathy, recurrent, with pressure palsies10.5
38neuropathy, inflammatory demyelinating10.5
39hereditary thermosensitive neuropathy10.5
40charcot-marie-tooth disease type 110.5
41refsum disease10.5
42juvenile glaucoma10.5
43neuropathy, hereditary motor and sensory, lom type10.5
44glaucoma, hereditary10.5
45neuropathy sensory spastic paraplegia10.5
46charcot-marie-tooth neuropathy type 2c10.5
47hereditary congenital facial paresis 310.4
48lambert-eaton myasthenic syndrome10.3
49superior mesenteric artery syndrome10.3
50cochlear disease10.3

Graphical network of the top 20 diseases related to Hereditary Neuropathy with Liability to Pressure Palsies:



Diseases related to hereditary neuropathy with liability to pressure palsies

Clinical Features for Hereditary Neuropathy with Liability to Pressure Palsies

Drugs & Therapeutics for Hereditary Neuropathy with Liability to Pressure Palsies

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hereditary Neuropathy with Liability to Pressure Palsies

Drug clinical trials:

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Search NIH Clinical Center for Hereditary Neuropathy with Liability to Pressure Palsies

Search CenterWatch for Hereditary Neuropathy with Liability to Pressure Palsies

Genetic Tests for Hereditary Neuropathy with Liability to Pressure Palsies

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20GeneTests
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Genetic tests related to Hereditary Neuropathy with Liability to Pressure Palsies:

id Genetic test Affiliating Genes
1 Hereditary Neuropathy With Liability To Pressure Palsies20 PMP22

Anatomical Context for Hereditary Neuropathy with Liability to Pressure Palsies

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33MalaCards
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MalaCards organs/tissues related to Hereditary Neuropathy with Liability to Pressure Palsies:

33
Brain, Spinal cord

Animal Models for Hereditary Neuropathy with Liability to Pressure Palsies or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Hereditary Neuropathy with Liability to Pressure Palsies

Genetic Variations for Hereditary Neuropathy with Liability to Pressure Palsies

Expression for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsies

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsies

Search GEO for disease gene expression data for Hereditary Neuropathy with Liability to Pressure Palsies.

Pathways for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsies

Sources:
38NCBI BioSystems Database
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Pathways related to Hereditary Neuropathy with Liability to Pressure Palsies according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GJB1, MPZ

Compounds for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsies

Sources:
45Novoseek
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Compounds related to Hereditary Neuropathy with Liability to Pressure Palsies according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ganglioside459.7MPZ, PMP22
2dihydroprogesterone459.6MPZ, PMP22
3arginine458.5PABPN1, GJB1, MPZ, PMP22

GO Terms for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsies

Products for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsies

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  • Lysates
  • Antibodies

Sources for Hereditary Neuropathy with Liability to Pressure Palsies

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet