HNPP
MCID: HRD054
MIFTS: 19

Hereditary Neuropathy with Liability to Pressure Palsy (HNPP) malady

Neuronal, Genetic categories

Summaries for Hereditary Neuropathy with Liability to Pressure Palsy

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43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Hereditary neuropathy with liability to pressure palsy (hnpp) is a disorder that affects peripheral nerves. this condition causes recurrent episodes of numbness, tingling, and/or loss of muscle function (palsy). an episode can last from several minutes to several months, but recovery is usually complete. repeated incidents, however, can cause permanent muscle weakness or loss of sensation. the most common problem sites involve nerves in wrists, elbows, and knees. symptoms usually begin during adolescence or early adulthood but may develop anytime from childhood to late adulthood. symptoms vary in severity; many people never realize they have the disorder, while some people experience prolonged disability. this condition is caused by the loss of one copy of the pmp22 gene or alterations within the gene. last updated: 7/23/2009

MalaCards: Hereditary Neuropathy with Liability to Pressure Palsy, also known as hereditary liability to pressure palsies, is related to hereditary neuropathy with liability to pressure palsies and tooth disease. An important gene associated with Hereditary Neuropathy with Liability to Pressure Palsy is PMP22 (peripheral myelin protein 22), and among its related pathways is Neural Crest Differentiation. The compounds ganglioside and dihydroprogesterone have been mentioned in the context of this disorder.

Wikipedia:64 Hereditary Neuropathy with Liability to Pressure Palsy (HNPP) is a peripheral neuropathy (disorder of... more...

Aliases & Classifications for Hereditary Neuropathy with Liability to Pressure Palsy

Sources:
43NIH Rare Diseases, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Neuronal


Aliases & Descriptions:

hereditary neuropathy with liability to pressure palsy 43
hereditary liability to pressure palsies 61
polyneuropathy, familial recurrent 43
tomaculous neuropathy 43
hnpp 43


Related Diseases for Hereditary Neuropathy with Liability to Pressure Palsy

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17GeneCards, 18GeneDecks
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Diseases in the hereditary neuropathy with liability to pressure palsies family:

hereditary neuropathy with liability to pressure palsy hereditary type 1 neuropathy
hereditary type 2 neuropathy

Diseases related to Hereditary Neuropathy with Liability to Pressure Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary neuropathy with liability to pressure palsies31.7PMP22
2tooth disease31.5MPZ, PMP22, GJB1
3hereditary neuropathies31.1PMP22, MPZ, GJB1
4brachial plexus neuropathy31.0PMP22, MPZ
5carpal tunnel syndrome31.0PMP22
6hereditary neuralgic amyotrophy31.0SEPT9
7pelizaeus-merzbacher disease30.7MPZ
8charcot-marie-tooth neuropathy type 130.7PMP22, MPZ
9chronic inflammatory demyelinating polyradiculoneuropathy30.7MPZ, PMP22
10charcot-marie-tooth hereditary neuropathy11.2
11chromosome 17p deletion10.8
12n syndrome10.7
13lateral sclerosis10.6
14peroneal neuropathy10.6
15amyotrophic lateral sclerosis10.6
16foot drop10.6
17axonal neuropathy10.5
18median neuropathy10.5
19oculopharyngeal muscular dystrophy10.5
20autosomal dominant disease10.5
21autosomal recessive disease10.5
22amyloid neuropathy10.5
23hereditary type 1 neuropathy10.5
24myoclonus10.5
25neuropathy, recurrent, with pressure palsies10.5
26neuropathy, inflammatory demyelinating10.5
27hereditary thermosensitive neuropathy10.5
28hereditary congenital facial paresis 310.4
29charcot-marie-tooth disease type 110.2
30char syndrome10.2
31polyradiculoneuropathy10.0PMP22
32charcot-marie-tooth neuropathy type 210.0MPZ
33motor peripheral neuropathy10.0PMP22, MPZ
34charcot-marie-tooth neuropathy type 1a10.0PMP22, MPZ
35charcot-marie-tooth disease10.0PMP22, MPZ
36charcot-marie-tooth disease type 4e10.0PMP22, MPZ
37neuritis10.0PMP22, MPZ
38diabetic neuropathy10.0PMP22, MPZ
39guillain-barre syndrome10.0PMP22, MPZ
40sensorineural hearing loss10.0GJB1, PMP22
41charcot-marie-tooth disease type 310.0MPZ, GJB1, PMP22
42sensory peripheral neuropathy10.0PMP22, MPZ, GJB1
43polyneuropathy10.0PMP22, GJB1, MPZ
44neurilemmoma10.0MPZ, PMP22
45sciatic neuropathy10.0
46chromosome 17p duplication10.0
47neuropathy10.0GJB1, PABPN1, SH3TC2, MPZ, PMP22
48myopathy10.0PGAM2, PMP22, COX10, MPZ, SH3TC2, GJB1

Graphical network of the top 20 diseases related to Hereditary Neuropathy with Liability to Pressure Palsy:



Diseases related to hereditary neuropathy with liability to pressure palsy

Clinical Features for Hereditary Neuropathy with Liability to Pressure Palsy

Drugs & Therapeutics for Hereditary Neuropathy with Liability to Pressure Palsy

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hereditary Neuropathy with Liability to Pressure Palsy

Anatomical Context for Hereditary Neuropathy with Liability to Pressure Palsy

Animal Models for Hereditary Neuropathy with Liability to Pressure Palsy or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Hereditary Neuropathy with Liability to Pressure Palsy

Genetic Variations for Hereditary Neuropathy with Liability to Pressure Palsy

Expression for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

Search GEO for disease gene expression data for Hereditary Neuropathy with Liability to Pressure Palsy.

Pathways for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

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38NCBI BioSystems Database
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Pathways related to Hereditary Neuropathy with Liability to Pressure Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GJB1, MPZ

Compounds for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

Sources:
45Novoseek
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Compounds related to Hereditary Neuropathy with Liability to Pressure Palsy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ganglioside459.7MPZ, PMP22
2dihydroprogesterone459.6MPZ, PMP22
3arginine458.5PABPN1, GJB1, MPZ, PMP22

GO Terms for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

Products for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

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Sources for Hereditary Neuropathy with Liability to Pressure Palsy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet