HNPP
MCID: HRD054
MIFTS: 21

Hereditary Neuropathy with Liability to Pressure Palsy (HNPP) malady

Neuronal diseases, Genetic diseases categories

Summaries for Hereditary Neuropathy with Liability to Pressure Palsy

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Hereditary neuropathy with liability to pressure palsy (hnpp) is a disorder that affects peripheral nerves. this condition causes recurrent episodes of numbness, tingling, and/or loss of muscle function (palsy). an episode can last from several minutes to several months, but recovery is usually complete. repeated incidents, however, can cause permanent muscle weakness or loss of sensation. the most common problem sites involve nerves in wrists, elbows, and knees. symptoms usually begin during adolescence or early adulthood but may develop anytime from childhood to late adulthood. symptoms vary in severity; many people never realize they have the disorder, while some people experience prolonged disability. this condition is caused by the loss of one copy of the pmp22 gene or alterations within the gene. last updated: 7/23/2009

MalaCards: Hereditary Neuropathy with Liability to Pressure Palsy, also known as hereditary liability to pressure palsies, is related to hereditary neuropathy with liability to pressure palsies and neuropathy. An important gene associated with Hereditary Neuropathy with Liability to Pressure Palsy is PMP22 (peripheral myelin protein 22), and among its related pathways is Neural Crest Differentiation. The compounds ganglioside and dihydroprogesterone have been mentioned in the context of this disorder.

Wikipedia:63 Hereditary Neuropathy with Liability to Pressure Palsy (HNPP) is a peripheral neuropathy (disorder of... more...

Aliases & Classifications for Hereditary Neuropathy with Liability to Pressure Palsy

About this section
Sources:
42NIH Rare Diseases, 60UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

hereditary neuropathy with liability to pressure palsy 42
hereditary liability to pressure palsies 60
polyneuropathy, familial recurrent 42
tomaculous neuropathy 42
hnpp 42


Related Diseases for Hereditary Neuropathy with Liability to Pressure Palsy

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hereditary Neuropathy with Liability to Pressure Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary neuropathy with liability to pressure palsies32.4PMP22
2neuropathy32.3PMP22, MPZ, SH3TC2, GJB1, PABPN1
3charcot-marie-tooth disease31.5PMP22, MPZ
4tooth disease31.5GJB1, MPZ, PMP22
5charcot-marie-tooth neuropathy type 131.0MPZ, PMP22
6brachial plexus neuropathy31.0MPZ, PMP22
7carpal tunnel syndrome31.0PMP22
8hereditary neuralgic amyotrophy31.0SEPT9
9polyneuropathy30.9GJB1, MPZ, PMP22
10polyradiculoneuropathy30.6PMP22
11charcot-marie-tooth neuropathy type 230.6MPZ
12pelizaeus-merzbacher disease30.6MPZ
13chronic inflammatory demyelinating polyradiculoneuropathy30.6PMP22, MPZ
14diabetic neuropathy30.6PMP22, MPZ
15charcot-marie-tooth hereditary neuropathy11.1
16peripheral neuropathy10.9
17lateral sclerosis10.6
18peroneal neuropathy10.6
19amyotrophic lateral sclerosis10.6
20radial neuropathy10.6
21axonal neuropathy10.5
22bell's palsy10.5
23charcot-marie-tooth disease type 210.5
24charcot-marie-tooth disease type 110.5
25median neuropathy10.5
26oculopharyngeal muscular dystrophy10.5
27autosomal dominant disease10.5
28autosomal recessive disease10.5
29chromosomal disease10.5
30diabetes mellitus10.5
31influenza10.5
32mononeuropathy10.5
33muscular dystrophy10.5
34neuropathy, recurrent, with pressure palsies10.5
35hereditary congenital facial paresis 310.3
36charcot-marie-tooth neuropathy type 1a10.0PMP22, MPZ
37motor peripheral neuropathy10.0PMP22, MPZ
38charcot-marie-tooth disease type 4e10.0PMP22, MPZ
39neuritis10.0MPZ, PMP22
40guillain-barre syndrome10.0MPZ, PMP22
41sensorineural hearing loss10.0GJB1, PMP22
42charcot-marie-tooth disease type 310.0PMP22, MPZ, GJB1
43hereditary neuropathies10.0GJB1, MPZ, PMP22
44sensory peripheral neuropathy10.0PMP22, MPZ, GJB1
45neurilemmoma10.0MPZ, PMP22
46myopathy10.0PMP22, COX10, MPZ, SH3TC2, PGAM2, GJB1
47sciatic neuropathy9.9
48demyelinating polyneuropathy9.9

Graphical network of the top 20 diseases related to Hereditary Neuropathy with Liability to Pressure Palsy:



Diseases related to hereditary neuropathy with liability to pressure palsy

Clinical Features for Hereditary Neuropathy with Liability to Pressure Palsy

About this section

Drugs & Therapeutics for Hereditary Neuropathy with Liability to Pressure Palsy

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Hereditary Neuropathy with Liability to Pressure Palsy

Drug clinical trials:

Search ClinicalTrials for Hereditary Neuropathy with Liability to Pressure Palsy

Search NIH Clinical Center for Hereditary Neuropathy with Liability to Pressure Palsy

Search CenterWatch for Hereditary Neuropathy with Liability to Pressure Palsy

Genetic Tests for Hereditary Neuropathy with Liability to Pressure Palsy

About this section

Anatomical Context for Hereditary Neuropathy with Liability to Pressure Palsy

About this section

Animal Models for Hereditary Neuropathy with Liability to Pressure Palsy or affiliated genes

About this section

Publications for Hereditary Neuropathy with Liability to Pressure Palsy

About this section

Genetic Variations for Hereditary Neuropathy with Liability to Pressure Palsy

About this section

Expression for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

Search GEO for disease gene expression data for Hereditary Neuropathy with Liability to Pressure Palsy.

Pathways for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

About this section
Sources:
37NCBI BioSystems Database
See all sources

Pathways related to Hereditary Neuropathy with Liability to Pressure Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GJB1, MPZ

Compounds for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

About this section
Sources:
44Novoseek
See all sources

Compounds related to Hereditary Neuropathy with Liability to Pressure Palsy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ganglioside449.7MPZ, PMP22
2dihydroprogesterone449.6MPZ, PMP22
3arginine448.5PABPN1, GJB1, MPZ, PMP22

GO Terms for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

About this section

Products for genes affiliated with Hereditary Neuropathy with Liability to Pressure Palsy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hereditary Neuropathy with Liability to Pressure Palsy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet