Hereditary Pancreatitis malady

CDC: Infection with hantavirus can progress to Hantavirus Pulmonary Syndrome (HPS), which can be fatal. People become infected through contact with hantavirus-infected rodents or their urine and droppings. The Sin Nombre hantavirus, first recognized in 1993, is one of several New World hantaviruses circulating in the US. Old World hantaviruses, found in Asia, can cause Hemorrhagic Fever with Renal Syndrome (HFRS). Rodent control in and around the home remains the primary strategy for preventing hantavirus infection. All cases of Hantavirus infection are reported to and researched by the Viral Special Pathogens Branch (VSPB) of the CDC.²

MalaCards: Hereditary Pancreatitis, also known as chronic pancreatitis, is related to tropical calcific pancreatitis and alcoholic pancreatitis. An important gene associated with Hereditary Pancreatitis is PRSS1 (protease, serine, 1 (trypsin 1)), and among its related pathways are Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks and Phase II conjugation. The drugs propantheline and propantheline bromide and the compounds mononucleotide and methylchloride have been mentioned in the context of this disorder. Affiliated tissues include pancreas, and related mouse phenotypes are endocrine/exocrine gland and embryogenesis.

Genetics Home Reference: Hereditary pancreatitis is a genetic condition characterized by recurrent episodes of inflammation of the pancreas (pancreatitis). The pancreas produces enzymes that help digest food, and it also produces insulin, a hormone that controls blood sugar levels in the body. Episodes of pancreatitis can lead to permanent tissue damage and loss of pancreatic function.¹⁷

Wikipedia: Hereditary Pancreatitis (HP) is an inflammation of the pancreas, attributed to genetic causes. It was...⁴⁴ more...

OMIM: 167800

hereditary pancreatitis 30 16 17 43 chronic pancreatitis 16 32 pancreatitis 17 43 autosomal dominant hereditary pancreatitis 17 pancreatitis, hereditary 33 pancreatitis hereditary 32

pancreatitis, calcific 43 calcific pancreatitis 16 pancreatitis, chronic 33 familial pancreatitis 17 hp 17

Diseases related to hereditary pancreatitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 668)

id	Related Disease	Score	Top Affiliating Genes
1	tropical calcific pancreatitis	34.2	REG1A, CFTR, SPINK1, CTSB, PRSS2, PRSS1
2	alcoholic pancreatitis	32.0	CFTR, GSTM1, GSTP1, GSTT1, TMPRSS15, SPINK1
3	pancreatic diseases	31.8	REG1A, CFTR, GSTM1, TMPRSS15, SPINK1, PRSS2
4	albinism	30.5	NBN, GSR, GSTM1, GSTP1, GSTT1
5	breast cancer	30.2	RAD51, PALB2, ATM
6	pancreatic ductal carcinoma	29.8	NBN, BRCA1, BRCA2, BRIP1, RAD51, ATM
7	steatorrhea	28.6	CFTR, TMPRSS15, PRSS1
8	alcoholic liver cirrhosis	28.4	GSTM1, GSTP1, GSTT1, HGF
9	primary hyperparathyroidism	28.3	BRCA2, CFTR, SPINK1, PRSS1
10	duodenitis	28.1	CFTR, CDKN2A, GSR, GSTM1, GSTP1, GSTT1
11	pancytopenia	27.7	NBN, FANCA, FANCC, FANCG
12	fanconi's anemia	27.2	BRCA2, BRIP1, PALB2, FANCD2, FANCA, FANCL
13	diabetes mellitus	27.2	REG1A, LPA, CFTR, CDKN2A, GSR, GSTM1
14	duodenal ulcer	27.1	CFTR, GSR, CTSB, PLG, SOD1
15	pancreatic carcinoma	26.9	RBBP8, BRCA2, CFTR, ATM, CDKN2A, SPINK1
16	cholangitis	26.8	CFTR, MST1, ATM, CDKN2A, GSTT1
17	primary biliary cirrhosis	26.6	REG1A, ATM, MGST1, GSTM1, GSTP1, GSTT1
18	jaundice	26.6	GSR, GSTM1, GSTT1, SOD1, HGF
19	age related macular degeneration	26.5	MGST1, GSR, GSTM1, GSTP1, GSTT1, SOD1
20	intestinal pseudo-obstruction	26.4	CFTR, SPINK1, PRSS1
21	prostate carcinoma	26.4	NBN, BRCA2, GSTM1, GSTT1
22	pneumonia	26.2	RAD51, RAD54B, CFTR, GSR, GSTM1, GSTP1
23	familial pancreatic cancer	26.0	BRCA1, BRCA2, CFTR, CDKN2A, FANCA, FANCC
24	diabetic retinopathy	25.9	LPA, GSTM1, GSTT1, PLG, SOD1, HGF
25	ovarian cancer	25.9	NBN, BRCA1, BRCA2, RAD50, ATR, MRE11A
26	liver cirrhosis	25.8	REG1A, CFTR, CDKN2A, GSTM1, GSTP1, GSTT1
27	werner syndrome	25.5	NBN, BRCA1, RAD51, RAD50, RAD54B, ATR
28	pituitary adenoma	25.4	REG1A, CDKN2A, GSTP1, CTSB, PLG, SOD1
29	laryngeal carcinoma	25.3	CDKN2A, MGST1, GSTM1, GSTM3, GSTP1, GSTT1
30	glaucoma	24.8	GSR, GSTM1, GSTM3, GSTP1, GSTT1, SOD1
31	laryngeal cancer	24.8	BRCA1, CDKN2A, GSR, GSTM1, GSTM3, GSTP1
32	osteoarthritis	24.8	LPA, GSR, GSTM1, GSTP1, GSTT1, CTSB
33	primary open angle glaucoma	24.6	GSTM1, GSTM3, GSTP1, GSTT1, SOD1
34	immunodeficiency	24.6	NBN, BRCA1, RAD51, RAD50, CHEK1, ATR
35	acute pancreatitis	24.6	REG1A, CFTR, GSR, GSTM1, GSTP1, GSTT1
36	open-angle glaucoma	24.5	GSTM1, GSTM3, GSTP1, GSTT1, SOD1
37	ulcerative colitis	24.4	REG1A, CFTR, MST1, CDKN2A, GSTM1, GSTP1
38	diabetic neuropathy	24.3	GSTM1, GSTT1, SOD1, HGF
39	nasopharyngitis	24.2	NBN, CHEK1, ATM, CDKN2A, GSTM1, GSTP1
40	wilms tumor	24.1	BRCA1, BRCA2, PALB2, CDKN2A, SOD1, HGF
41	diffuse large b-cell lymphoma	24.0	NBN, BRCA1, BRCA2, ATM, CDKN2A, GSTM1
42	nephropathy	24.0	REG1A, LPA, CDKN2A, GSTM1, GSTP1, GSTT1
43	cystic fibrosis	23.9	REG1A, BRCA1, RAD51, CFTR, GSR, GSTM1
44	retinoblastoma	23.9	RBBP8, NBN, BRCA1, BRCA2, CHEK1, CDKN2A
45	b-cell lymphomas	23.8	NBN, BRCA1, BRCA2, MST1, ATM, CDKN2A
46	esophageal cancer	23.8	REG1A, BRCA2, RAD51, ATM, CDKN2A, GSR
47	pandas	23.8	BRCA1, BRCA2, ATM, CDKN2A, GSR, GSTM1
48	familial adenomatous polyposis	23.8	BRCA1, GSTM1, GSTP1, GSTT1, SPINK1, SOD1
49	endometriosis	23.8	BRCA1, BRCA2, MST1, CDKN2A, MGST1, GSTM1
50	rheumatoid arthritis	23.7	LPA, CFTR, ATM, GSR, GSTM1, GSTM3

Clinical features from OMIM: 167800

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 propantheline, propantheline bromide

MalaCards organs/tissues related to hereditary pancreatitis:

²²

MGI Mouse Phenotypes related to hereditary pancreatitis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	7.8	FANCL, REG1A, NBN, BRCA1, BRCA2, FANCM
2	embryogenesis phenotype	MP:0005380	7.0	RBBP8, NBN, BRCA1, BRCA2, RAD51, RAD50
3	reproductive system phenotype	MP:0005389	6.7	TP53BP1, NBN, BRCA1, BRCA2, RAD50, USP1
4	immune system phenotype	MP:0005387	6.6	MCPH1, TP53BP1, CTSB, NBN, BRCA1, BRCA2
5	tumorigenesis	MP:0002006	5.9	ATM, MRE11A, CDKN2A, GSTP1, FANCD2, FANCA
6	homeostasis/metabolism phenotype	MP:0005376	5.8	PLG, BRCA2, RAD54B, FANCL, USP1, CFTR
7	mortality/aging	MP:0010768	5.6	CTSB, CHEK1, PALB2, USP1, RAD54B, RAD51D
8	hematopoietic system phenotype	MP:0005397	5.2	MDC1, CDKN2A, MRE11A, ATM, ATR, MST1
9	growth/size phenotype	MP:0005378	5.2	FANCD2, MDC1, FANCA, FANCL, TP53BP1, SPINK1
10	cellular phenotype	MP:0005384	3.1	RAD50, BRCA2, MCPH1, FANCD2, FANCA, FANCL

Articles related to hereditary pancreatitis:

(show top 50)    (show all 53)

id	Title	Authors	Year	Affiliating Genes
1	Intragenic duplication: a novel mutational mechanism in hereditary pancreatitis. (21499207)	Joergensen M.T.... Sahin-TA^th M.	2011	PRSS1
2	Uncertainties in the classification of human cationic trypsinogen (PRSS1) variants as hereditary pancreatitis-associated mutations. (20452997)	Szmola R.... Sahin-TA^th M.	2010	PRSS1
3	Pathology analysis reveals that dysplastic pancreatic ductal lesions are frequent in patients with hereditary pancreatitis. (19765677)	Rebours V.... Couvelard A.	2010	PRSS1
4	Hereditary pancreatitis in children: surgical implica tions with special regard to genetic background. (19944211)	Schmitt F.... Podevin G.	2009	CFTR, SPINK1
5	The natural history of hereditary pancreatitis: a national series. (18755888)	Rebours V.... Levy P.	2009	PRSS1
6	Hereditary pancreatitis: clinical features and inheritance characteristics of the R122C mutation in the cationic trypsinogen gene (PRSS1) in six Spanish families. (19454815)	de las Heras-CastaA+o G.... SA!nchez-JuA!n P.	2009	PRSS1
7	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (19690177)	McWilliams R.R.... Petersen G.M.	2009	CHEK1, ATM, RAD51
8	Chronic hereditary pancreatitis in a girl with a serine protease inhibitor kazal type I (SPINK-1) gene mutation and a coxsackie type B5 infection. (19106771)	Groeneweg M.... Nieuwenhuis E.E.	2009	SPINK1
9	Dutch patients with hereditary pancreatitis; high mu tation frequency, relatively little pain (19857283)	Derikx M.H.... Drenth J.P.	2009	PRSS1
10	Hereditary pancreatitis in a child (19686634)	Freira S.... Cabral J.	2009	PRSS1
11	Novel mutation and polymorphism of PRSS1 gene in the Chinese patients with hereditary pancreatitis and chronic pancreatitis. (18272034)	Liu Q.C.... Cheng Z.J.	2008	PRSS1
12	Local clustering of PRSS1 R122H mutations in hereditary pancreatitis patients from Northern Germany. (18702646)	Weiss F.U.... Lerch M.M.	2008	PRSS1
13	Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series. (18184119)	Rebours V.... Levy P.	2008	PRSS1
14	A novel A121T mutation in human cationic trypsinogen associated with hereditary pancreatitis: functional data indicating a loss-of-function mutation influencing the R122 trypsin cleavage site. (18511571)	Felderbauer P.... Schmidt W.E.	2008	PRSS1
15	Hereditary pancreatitis caused by a double gain-of-function trypsinogen mutation. (18461367)	Masson E.... Ferec C.	2008	PRSS1, PRSS2
16	A novel mutation of PRSS1 gene in a Chinese hereditary pancreatitis family (17855255)	Liu Q.C.... Ou Q.S.	2007	PRSS1
17	Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. (17274009)	Kiraly O.... Ferec C.	2007	SPINK1
18	Three cases of hereditary pancreatitis in two households in the same family associated with R122H mutation in cationic trypsinogen gene (17641559)	Lee T.Y.... Lee S.K.	2007	PRSS1
19	Screening for human cationic trypsinogen (PRSS1) and trypsinogen inhibitor gene (SPINK1) mutations in a Finnish family with hereditary pancreatitis. (17613931)	Raty S.... Herzig K.H.	2007	PRSS1, SPINK1
20	A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. (17087933)	Archer H.... Bar-Sagi D.	2006	PRSS1
21	Hereditary pancreatitis caused by triplication of the trypsinogen locus. (17072318)	Le Marechal C.... Ferec C.	2006	PRSS1
22	Biochemical models of hereditary pancreatitis. (16632094)	Sahin-Toth M.	2006	PRSS1, SPINK1
23	Hereditary pancreatitis and secondary screening for early pancreatic cancer. (16358943)	Vitone L.J.... Neoptolemos J.P.	2005	PRSS1
24	A Thai family with hereditary pancreatitis and increased cancer risk due to a mutation in PRSS1 gene. (15786540)	Pho-iam T.... Limwongse C.	2005	PRSS1
25	Hereditary pancreatitis (15725720)	Kim Y.T.	2005	CFTR, PRSS1, SPINK1
26	A case of R122H mutation of cationic trypsinogen gene in a pediatric patient with hereditary pancreatitis complicated by pseudocyst and hemosuccus pancreaticus (15725718)	Kim J.Y.... Kim C.M.	2005	PRSS1
27	Hereditary pancreatitis (16301849)	Lee S.K.	2005	PRSS1
28	Genetic counseling for hereditary pancreatitis--the role of molecular genetics testing for the cationic trypsinogen gene, cystic fibrosis and serine protease inhibitor Kazal type 1. (15528021)	Ellis I.	2004	CFTR, SPINK1
29	Two novel severe mutations in the pancreatic secretory trypsin inhibitor gene (SPINK1) cause familial and/or hereditary pancreatitis. (14722925)	Le Marechal C.... Ferec C.	2004	SPINK1
30	Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. (15338373)	Schneider A.... Whitcomb D.C.	2004	GSTT1, GSTM3, GSTM1
31	Hereditary pancreatitis as the premalignant disease: a Japanese case of pancreatic cancer involving the SPINK1 gene mutation N34S. (15084977)	Masamune A.... Shimosegawa T.	2004	SPINK1
32	Clinical and genetic characteristics of hereditary pancreatitis in Europe. (15017610)	Howes N.... Neoptolemos J.P.	2004	PRSS1
33	Hereditary pancreatitis. (12508340)	Charnley R.M.	2003	PRSS1
34	Gene symbol: Spink1-Omim 167790. Disease: hereditary pancreatitis. (12974284)	Deybach J.-C.D.... Ruszniewski P.	2003	SPINK1
35	Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis. (11932257)	Kukor Z.... Sahin-Toth M.	2002	CTSB, PRSS1
36	Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen. (11719509)	Simon P.... Lerch M.M.	2002	PRSS1, TMPRSS15
37	Lessons from hereditary pancreatitis. (11471204)	Whitcomb D.C.... Somogyi L.	2001	PRSS1
38	Mutations of the cationic trypsinogen gene in hereditary and non-hereditary pancreatitis. (11549837)	O'Reilly D.A.... Kingsnorth A.N.	2001	PRSS1
39	Hereditary pancreatitis in Japan: a review of pancreatitis-associated gene mutations. (12120222)	Nishimori I.... Onishi S.	2001	CFTR, SPINK1
40	Role of hereditary pancreatitis and CFTR gene mutations in the aetiology of acute relapsing pancreatitis of unknown origin. How are they important? (11880696)	Uomo G.... Rabitti P.G.	2001	CFTR
41	Hereditary pancreatitis in North America: the Pittsburgh-Midwest Multi-Center Pancreatic Study Group Study. (12120221)	Applebaum-Shapiro S.E.... Whitcomb D.C.	2001	PRSS1
42	A new polymorphism for the RI22H mutation in hereditary pancreatitis. (11156648)	Howes N.... Neoptolemos J.P.	2001	PRSS1
43	Mutations of the cationic trypsinogen gene in patients with hereditary pancreatitis. (10671922)	Creighton J.E.... Charnley R.M.	2000	PRSS1
44	Evidence that hereditary pancreatitis is genetically heterogeneous disorder. (10653140)	Ravnik-Glavac M.... Glavac D.	2000	CFTR
45	Molecular basis of hereditary pancreatitis. (10909845)	Chen J.M.... Ferec C.	2000	PRSS1
46	Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis. (10204851)	Ferec C.... Le Bodic L.	1999	PRSS1
47	Hereditary pancreatitis and familial pancreatic cancer. (9438603)	Finch M.D.... Neoptolemos J.P.	1997	BRCA2, CDKN2A
48	Antioxidants in hereditary pancreatitis. (8759661)	Mathew P.... Kay M.H.	1996	SOD1, GSTP1, GSR
49	Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. (8841182)	Whitcomb D.C.... Ehrlich G.D.	1996	PRSS1
50	Analysis of pancreatic stone protein gene of hereditary pancreatitis (1578808)	Suzuki T.... Takeyama Y.	1992	REG1A

Genes related to hereditary pancreatitis according to GeneCards:

(show all 48)

id	Symbol	Description	Score	GeneCards Section Context
1	PRSS1	protease, serine, 1 (trypsin 1)	11.1	Summaries, Publications
2	SPINK1	serine peptidase inhibitor, Kazal type 1	11.0	Publications, Summaries
3	MST1P9	macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 9	11.0	Orthologs
4	RAD51D	RAD51 homolog D (S. cerevisiae)	11.0	Publications
5	PRSS2	protease, serine, 2 (trypsin 2)	11.0	Publications
6	FANCF	Fanconi anemia, complementation group F	11.0	Publications
7	USP1	ubiquitin specific peptidase 1	11.0	Publications
8	FANCE	Fanconi anemia, complementation group E	11.0	Publications
9	SHFM1	split hand/foot malformation (ectrodactyly) type 1	11.0	Publications
10	FANCG	Fanconi anemia, complementation group G	11.0	Publications
11	MST1	macrophage stimulating 1 (hepatocyte growth factor-like)	11.0	Orthologs
12	MGST1	microsomal glutathione S-transferase 1	11.0	Publications
13	REG1A	regenerating islet-derived 1 alpha	11.0	Publications
14	GSTM3	glutathione S-transferase mu 3 (brain)	11.0	Publications
15	PALB2	partner and localizer of BRCA2	11.0	Publications
16	FANCM	Fanconi anemia, complementation group M	11.0	Publications
17	MDC1	mediator of DNA-damage checkpoint 1	11.0	Publications
18	TOPBP1	topoisomerase (DNA) II binding protein 1	11.0	Publications
19	FANCL	Fanconi anemia, complementation group L	11.0	Publications
20	RAD54B	RAD54 homolog B (S. cerevisiae)	11.0	Publications
21	RBBP8	retinoblastoma binding protein 8	11.0	Publications
22	FANCD2	Fanconi anemia, complementation group D2	11.0	Publications
23	TP53BP1	tumor protein p53 binding protein 1	11.0	Publications
24	FANCA	Fanconi anemia, complementation group A	11.0	Publications
25	TMPRSS15	transmembrane protease, serine 15	11.0	Publications
26	BRIP1	BRCA1 interacting protein C-terminal helicase 1	11.0	Publications
27	PLG	plasminogen	11.0	Orthologs
28	RAD50	RAD50 homolog (S. cerevisiae)	11.0	Publications
29	NBN	nibrin	11.0	Publications
30	RAD51	RAD51 homolog (S. cerevisiae)	11.0	Publications
31	MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	11.0	Publications
32	FANCC	Fanconi anemia, complementation group C	11.0	Publications
33	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0	Publications
34	BRCA2	breast cancer 2, early onset	11.0	Publications
35	ATR	ataxia telangiectasia and Rad3 related	11.0	Publications
36	GSTT1	glutathione S-transferase theta 1	11.0	Publications
37	CHEK1	checkpoint kinase 1	11.0	Publications
38	LPA	lipoprotein, Lp(a)	11.0	Orthologs
39	MCPH1	microcephalin 1	11.0	Publications
40	GSTM1	glutathione S-transferase mu 1	11.0	Publications
41	ATM	ataxia telangiectasia mutated	11.0	Publications
42	CTSB	cathepsin B	11.0	Publications
43	GSTP1	glutathione S-transferase pi 1	11.0	Publications
44	GSR	glutathione reductase	11.0	Publications
45	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Orthologs
46	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
47	BRCA1	breast cancer 1, early onset	11.0	Publications
48	SOD1	superoxide dismutase 1, soluble	11.0	Publications

Pathways related to hereditary pancreatitis according to GeneDecks:

(show all 36)

id	Pathway	Score	Top Affiliating Genes
1	Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks38	10.2	MRE11A, NBN, RAD50
2	Phase II conjugation38	9.8	MGST1, GSTM1, GSTP1
3	Cell cycle Role of 14-3-3 proteins in cell cycle regulation10	9.7	ATM, ATR, CHEK1
4	Naphthalene metabolism41	9.7	GSTP1, GSTM1, GSTT1
5	Cell cycle_Role of 14-3-3 proteins in cell cycle regulation41	9.7	ATM, CHEK1, ATR
6	Naphthalene metabolism10	9.7	GSTM1, GSTT1, GSTP1
7	Fanconi Anemia pathway38	9.6	FANCF, FANCD2, PALB2, USP1, FANCA, FANCL
8	Metabolism of xenobiotics by cytochrome P45020	9.5	GSTM3, GSTT1, GSTP1, MGST1, GSTM1
9	Homologous recombination20	9.5	RAD50, NBN, SHFM1, MRE11A, RAD54B, RAD51D
10	Drug metabolism - cytochrome P45020	9.5	GSTP1, MGST1, GSTM1, GSTM3, GSTT1
11	Pathway_PA16598033734	9.5	SOD1, GSR
12	Oxidative Stress Pathway (Erythrocyte)34	9.4	GSR, SOD1
13	DNA damage_NHEJ mechanisms of DSBs repair41	9.4	NBN, BRCA1, RAD50, MRE11A
14	DNA damage NHEJ mechanisms of DSBs repair10	9.4	NBN, RAD50, MRE11A, BRCA1
15	DNA damage ATM/ATR regulation of G1/S checkpoint10	9.3	ATR, ATM, MDC1, FANCD2, FANCL, USP1
16	DNA Damage Induced 14-3-3Sigma Signaling36	9.3	BRCA1, ATR, ATM
17	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	9.3	GSTM1, SOD1, GSTP1, GSTT1
18	p53 signaling pathway20	9.2	CDKN2A, ATR, ATM, CHEK1
19	Oxidative Stress Pathway (Erythrocyte)34	9.2	SOD1, GSR
20	Glutathione metabolism10	9.2	GSTP1, GSTM1, GSTM3, GSTT1, GSR, MGST1
21	Glutathione metabolism41	9.2	GSR, GSTM1, GSTM3, GSTP1, GSTT1, MGST1
22	Glutathione metabolism20	9.1	GSTT1, GSTP1, GSR, MGST1, GSTM1, GSTM3
23	Meiosis10	9.1	TOPBP1, FANCL, FANCG, FANCD2, RAD54B, BRCA1
24	GADD45 Pathway36	9.1	ATR, ATM, BRCA1
25	DNA damage DNA-damage-induced responses10	9.0	ATM, CHEK1, MDC1, BRCA1, ATR
26	DNA damage_DNA-damage-induced responses41	9.0	ATM, BRCA1, CHEK1, MDC1, ATR
27	Chks in Checkpoint Regulation36	8.7	ATR, RAD50, BRCA1, CHEK1, ATM, MRE11A
28	ATM Pathway36	8.6	MDC1, FANCD2, BRCA1, RAD51, MRE11A, RAD50
29	DNA damage_ATM/ATR regulation of G1/S checkpoint41	8.5	ATR, NBN, BRCA1, USP1, CHEK1, MDC1
30	DNA damage Role of Brca1 and Brca2 in DNA repair10	7.8	TP53BP1, FANCL, FANCD2, NBN, BRCA1, BRCA2
31	DNA damage_Role of Brca1 and Brca2 in DNA repair41	7.8	TP53BP1, FANCL, NBN, BRCA1, BRCA2, BRIP1
32	Fanconis Anaemia Pathway36	7.8	MRE11A, RAD51, BRCA2, BRCA1, ATM, ATR
33	DNA Repair Mechanisms36	7.6	BRCA1, BRCA2, RAD50, CHEK1, ATR, ATM
34	DNA Damage3	7.6	CHEK1, ATR, ATM, MRE11A, MCPH1, FANCD2
35	BRCA1 Pathway36	7.3	FANCC, FANCF, FANCE, FANCL, FANCA, FANCD2
36	Cell Cycle / Checkpoint Control3	6.4	TP53BP1, FANCD2, MCPH1, GSTP1, NBN, BRCA1

Compounds related to hereditary pancreatitis according to GeneDecks:

(show top 50)    (show all 111)

id	Compound	Score	Top Affiliating Genes
1	mononucleotide32	10.0	RBBP8, NBN, MRE11A, RAD50
2	methylchloride32	9.8	GSTM1, GSTP1, GSTT1
3	noradrenochrome32 18	10.7	GSTM1, MGST1, GSTP1, GSTT1, GSTM3
4	hydrochloric acid32 18	10.6	MGST1, GSTM3, GSTT1, GSTP1, GSTM1
5	1-chloro-24-dinitrobenzene32	9.6	GSTP1, GSTT1, GSTM1, MGST1
6	trypsinogen32	9.6	REG1A, CFTR, TMPRSS15, SPINK1, CTSB, PRSS2
7	s-phenylmercapturic acid32	9.5	GSTP1, GSTT1, GSTM1
8	epoxide32	9.4	GSTT1, GSTP1, GSTM3, GSTM1, MGST1
9	rpa 232	9.4	RAD51, CHEK1, ATR, CDKN2A, FANCD2
10	cumene hydroperoxide32	9.4	GSTT1, GSTM1, GSTP1, GSR
11	chlorambucil32 9 9	11.4	GSTP1, RAD51, MGST1, GSR, GSTM1
12	gsts32	9.2	GSR, GSTP1, GSTM3, GSTM1, MGST1, GSTT1
13	Glutathione9 18 9	11.2	GSR, GSTM3, GSTM1, MGST1, GSTP1, GSTT1
14	adrenochrome32 18	10.2	GSTM3, GSTM1, GSTT1, MGST1, GSTP1, SOD1
15	glutathion32	9.1	SOD1, GSTP1, GSR, GSTM1
16	melphalan32 9 9	11.1	GSR, RAD51, GSTP1, FANCC, FANCD2
17	8-oxoguanine32	8.9	BRCA1, GSTT1, GSTM1, BRCA2
18	diepoxybutane32	8.9	FANCG, FANCC, FANCA, FANCD2, GSTT1, GSTM1
19	aphidicolin32	8.9	ATM, FANCD2, BRCA1, ATR, RAD51, CHEK1
20	h2o232	8.8	BRCA2, LPA, RAD51, CHEK1, CFTR, MGST1
21	methylmethanesulfonate32	8.6	RAD51, CHEK1, NBN, BRCA1, BRCA2, TP53BP1
22	etoposide32 42 9 9	11.6	CHEK1, HGF, CTSB, TP53BP1, ATM, ATR
23	caffeine32 34 9 18 9	12.6	ATR, CFTR, CHEK1, BRCA1, ATM, TP53BP1
24	histidine32	8.6	CHEK1, CDKN2A, RAD51, HGF, PLG, CTSB
25	arginine32	8.5	GSR, MRE11A, TP53BP1, RAD51, PRSS1, TMPRSS15
26	manganese superoxide32	8.5	SOD1, GSTT1, ATM, GSTP1, GSTM1, GSR
27	bpde32	8.5	GSTP1, GSTT1, BRCA1, ATM, CHEK1, GSTM1
28	malondialdehyde32	8.4	HGF, GSTT1, GSTM1, GSR, SOD1, LPA
29	lycopene32 18	9.4	BRCA2, SOD1, GSTP1, GSR, BRCA1
30	bleomycin32 9 9	10.1	GSTP1, HGF, GSTM1, ATM, BRCA2, BRCA1
31	thymidylate32	8.1	CDKN2A, GSTP1, GSTM1, CFTR, RAD51, BRCA1
32	cysteine32	7.7	CTSB, GSTP1, BRCA1, GSTM1, CDKN2A, CFTR
33	hydroxyurea32 9 9	9.4	TP53BP1, TOPBP1, FANCD2, CDKN2A, ATM, NBN
34	selenium32 18	8.2	SOD1, BRCA1, CDKN2A, HGF, GSR
35	methotrexate32 34 42 9 9	11.2	GSTP1, HGF, CDKN2A, GSTM1, BRCA2, BRCA1
36	paclitaxel32 34 9 9	10.2	CDKN2A, PLG, CTSB, GSTP1, CHEK1, RAD51
37	n acetylcysteine32	7.2	CFTR, CHEK1, NBN, ATM, CDKN2A, GSR
38	5fluorouracil32	7.0	CTSB, GSTP1, HGF, CDKN2A, CHEK1, BRCA1
39	adriamycin32	7.0	SOD1, HGF, GSTP1, BRCA1, CHEK1, GSR
40	folate32	7.0	CDKN2A, BRCA2, BRCA1, LPA, GSR, GSTM1
41	mitomycin c32	6.9	NBN, BRCA1, BRCA2, RAD51, CFTR, MRE11A
42	creatinine32	6.9	SOD1, GSTM1, CTSB, GSTT1, HGF, SPINK1
43	genistein32 9 18 9	9.9	ATM, BRCA1, REG1A, HGF, GSTP1, GSR
44	camptothecin32 42 9 9	9.7	CTSB, RAD50, RAD51, TP53BP1, GSTP1, CDKN2A
45	oxygen32 18	7.4	CTSB, ATM, CHEK1, BRCA1, CDKN2A, GSR
46	doxorubicin32 34 9 9	9.1	HGF, GSR, NBN, BRCA1, CTSB, GSTT1
47	alanine32	6.1	GSTP1, CHEK1, CFTR, GSR, FANCA, RAD51
48	cisplatin32 34 9 9	9.0	FANCD2, ATM, CHEK1, CFTR, BRCA2, CDKN2A
49	serine32	5.9	MST1, CTSB, PLG, PRSS2, PRSS1, TMPRSS15
50	estrogen32	5.4	GSTT1, CTSB, HGF, CHEK1, GSTM1, BRCA2

Cellular components related to hereditary pancreatitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	condensed nuclear chromosome	GO:000794	9.8	RAD51, MRE11A, CHEK1
2	Mre11 complex	GO:030870	9.8	NBN, RAD50, MRE11A
3	Fanconi anaemia nuclear complex	GO:043240	9.6	FANCL, FANCE, FANCF, FANCC, FANCG, FANCA
4	chromosome, telomeric region	GO:000781	9.2	ATM, MRE11A, TP53BP1, CHEK1
5	nucleoplasm	GO:005654	5.7	MDC1, ATR, ATM, MRE11A, CDKN2A, TP53BP1

Biological processes related to hereditary pancreatitis according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	mitotic recombination	GO:006312	10.1	RAD54B, RAD51
2	positive regulation of kinase activity	GO:033674	10.1	RAD50, NBN, MRE11A
3	positive regulation of protein autophosphorylation	GO:031954	10.0	RAD50, MRE11A, NBN
4	regulation of mitotic recombination	GO:000019	10.0	RAD50, MRE11A
5	DNA duplex unwinding	GO:032508	10.0	RAD50, MRE11A, NBN, RAD54B
6	extracellular matrix disassembly	GO:022617	9.8	PLG, PRSS2, PRSS1
7	DNA damage checkpoint	GO:000077	9.8	NBN, BRIP1, CHEK1, ATR
8	reciprocal meiotic recombination	GO:007131	9.6	RAD51, RAD50, RAD51D, RAD54B, MRE11A, ATM
9	positive regulation of DNA damage response, signal transduction by p53 class mediator	GO:043517	9.3	CDKN2A, ATR, ATM
10	replicative senescence	GO:090399	9.2	ATM, CDKN2A, ATR, CHEK1
11	G2/M transition DNA damage checkpoint	GO:031572	9.1	ATM, BRCA1, CHEK1, RBBP8
12	glutathione metabolic process	GO:006749	8.9	GSR, GSTM3, GSTP1, GSTT1, SOD1, MGST1
13	cell cycle checkpoint	GO:000075	8.8	RBBP8, FANCG, CDKN2A, MRE11A, ATM, ATR
14	proteolysis	GO:006508	8.7	HGF, TMPRSS15, PLG, PRSS1, LPA, SHFM1
15	response to DNA damage stimulus	GO:006974	8.3	TOPBP1, FANCL, BRCA1, RAD50, CHEK1, ATR
16	double-strand break repair via homologous recombination	GO:000724	7.9	RBBP8, NBN, BRCA1, BRCA2, RAD51, RAD50
17	double-strand break repair	GO:006302	7.7	SOD1, TP53BP1, MDC1, MRE11A, ATM, RAD50
18	DNA repair	GO:006281	6.2	FANCF, FANCE, FANCL, FANCA, FANCD2, MDC1

Molecular functions related to hereditary pancreatitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	single-stranded DNA specific endodeoxyribonuclease activity	GO:000014	10.0	MRE11A, RAD50
2	damaged DNA binding	GO:003684	9.9	RAD51, NBN, RBBP8, FANCG
3	ATP-dependent DNA helicase activity	GO:004003	9.4	BRIP1, NBN, RAD50, MRE11A
4	glutathione transferase activity	GO:004364	9.3	MGST1, GSTP1, GSTM3, GSTT1, GSTM1
5	serine-type endopeptidase activity	GO:004252	9.1	LPA, MST1, MST1P9, TMPRSS15, PRSS2, PRSS1
6	protein binding	GO:005515	2.8	HGF, MDC1, GSTP1, MGST1, CDKN2A, MRE11A