HP
MCID: HRD057
MIFTS: 64

Hereditary Pancreatitis (HP) malady

Genetic diseases, Rare diseases, Endocrine diseases, Gastrointestinal diseases, Bone diseases, Immune diseases categories

Summaries for Hereditary Pancreatitis

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4CDC, 22Genetics Home Reference, 66Wikipedia, 48OMIM, 34MalaCards
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CDC:4 Infection with hantavirus can progress to Hantavirus Pulmonary Syndrome (HPS), which can be fatal. People become infected through contact with hantavirus-infected rodents or their urine and droppings. The Sin Nombre hantavirus, first recognized in 1993, is one of several New World hantaviruses circulating in the US. Old World hantaviruses, found in Asia, can cause Hemorrhagic Fever with Renal Syndrome (HFRS). Rodent control in and around the home remains the primary strategy for preventing hantavirus infection. All cases of Hantavirus infection are reported to the CDC.

MalaCards: Hereditary Pancreatitis, also known as autosomal dominant hereditary pancreatitis, is related to pancreatitis and pancreatic cancer. An important gene associated with Hereditary Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Pancreatic secretion and Etoposide Pathway, Pharmacokinetics/Pharmacodynamics. The compounds methylchloride and s-phenylmercapturic acid have been mentioned in the context of this disorder. Affiliated tissues include pancreas and testes, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Genetics Home Reference:22 Hereditary pancreatitis is a genetic condition characterized by recurrent episodes of inflammation of the pancreas (pancreatitis). The pancreas produces enzymes that help digest food, and it also produces insulin, a hormone that controls blood sugar levels in the body. Episodes of pancreatitis can lead to permanent tissue damage and loss of pancreatic function.

Wikipedia:66 Hereditary Pancreatitis (HP) is an inflammation of the pancreas, attributed to genetic causes. It was... more...

Description from OMIM:48 167800

Aliases & Classifications for Hereditary Pancreatitis

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44NIH Rare Diseases, 21GeneTests, 23GTR, 22Genetics Home Reference, 63UMLS, 48OMIM, 46Novoseek
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Classifications:



Aliases & Descriptions:

hereditary pancreatitis 44 21 23 22 63
autosomal dominant hereditary pancreatitis 22
hereditary chronic pancreatitis 22
pancreatitis, hereditary 48
pancreatitis hereditary 46
pancreatitis, calcific 63
familial pancreatitis 22
hp 22


Related Diseases for Hereditary Pancreatitis

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18GeneCards, 19GeneDecks
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Diseases in the Hereditary Pancreatitis family:

Acute Pancreatitis Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Pancreatitis, Chronic
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Hereditary Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.3REG1A, PRSS2, PRSS1, BRCA2, SOD1, TMPRSS15
2pancreatic cancer30.6CDKN2A, BRCA2, SPINK1
3cystic fibrosis30.3SPINK1, CFTR, PRSS1, GSTM1
4alcoholic pancreatitis30.3CFTR, SPINK1
5methemoglobinemia30.2GSR
6pancreatitis, chronic30.0SPINK1, CFTR, TMPRSS15, SOD1, PRSS1, REG1A
7recurrent acute pancreatitis30.0SOD1, CFTR, SPINK1
8diabetes mellitus29.8SPINK1, SOD1, REG1A, GSR
9acute pancreatitis29.8SPINK1, CFTR, TMPRSS15, SOD1, PRSS2, REG1A
10lung cancer29.8GSTM1, GSTP1, CDKN2A
11adenocarcinoma29.8SPINK1, BRCA2, PRSS1, REG1A, GSTM1, GSTP1
12melanoma29.7CFTR, BRCA2, GSTT1, CDKN2A, CTSB
13hermansky-pudlak syndrome10.5
14hantavirus pulmonary syndrome10.4
15malaria10.3
16coronary artery disease10.3
17artery disease10.3
18anhaptoglobinemia10.3
19pancreatic carcinoma, familial10.3
20prss1-related hereditary pancreatitis10.2
21diabetic nephropathy10.2
22pulmonary tuberculosis10.2
23hemoglobinuria10.2
24autoimmune hemolytic anemia10.2
25favism10.2
26plasmodium falciparum malaria10.2
27hellp syndrome10.2
28extrinsic allergic alveolitis10.2
29mastitis10.2
30cluster headache10.2
31headache10.2
32hermansky-pudlak syndrome 110.1
33tropical calcific pancreatitis10.1SPINK1
34diabetic cataract10.1GSR
35aminoaciduria10.1
36spink1-related hereditary pancreatitis10.1
37ctrc-related hereditary pancreatitis10.1
38cftr-related hereditary pancreatitis10.1
39steatorrhea10.1TMPRSS15, CFTR
40neuropathy10.1
41brain cancer10.1GSTT1, GSTM1
42asbestosis10.1GSTT1, GSTM1
43evans' syndrome10.1
44hepatopulmonary syndrome10.1
45priapism10.1
46hereditary elliptocytosis10.1
47scurvy10.1
48trachoma10.1
49congenital disorder of glycosylation type i10.1
50bronchopneumonia10.1

Graphical network of the top 20 diseases related to Hereditary Pancreatitis:



Diseases related to hereditary pancreatitis

Symptoms for Hereditary Pancreatitis

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48OMIM
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Clinical features from OMIM:

167800

Drugs & Therapeutics for Hereditary Pancreatitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hereditary Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Hereditary Pancreatitis

Search NIH Clinical Center for Hereditary Pancreatitis

Search CenterWatch for Hereditary Pancreatitis

Genetic Tests for Hereditary Pancreatitis

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21GeneTests, 23GTR
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Genetic tests related to Hereditary Pancreatitis:

id Genetic test Affiliating Genes
1 Hereditary Pancreatitis21 23 SPINK1

Anatomical Context for Hereditary Pancreatitis

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34MalaCards
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MalaCards organs/tissues related to Hereditary Pancreatitis:

34
Pancreas, Testes

Animal Models for Hereditary Pancreatitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hereditary Pancreatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7CTSB, CDKN2A, BRCA2, CFTR, SPINK1
2MP:00053797.3SPINK1, CFTR, SOD1, BRCA2, REG1A, CDKN2A
3MP:00053766.5CTSB, SPINK1, CFTR, TMPRSS15, SOD1, BRCA2

Publications for Hereditary Pancreatitis

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53PubMed
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Articles related to Hereditary Pancreatitis:

(show top 50)    (show all 188)
idTitleAuthorsYear
1
Genetic, epidemiological, and clinical aspects of hereditary pancreatitis: a population-based cohort study in Denmark. (20502448)
2010
2
Comments on hereditary pancreatitis. (19592702)
2009
3
Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (19690177)
2009
4
Mortality rate and risk factors in patients with hereditary pancreatitis: uni- and multidimensional analyses. (19550412)
2009
5
Local clustering of PRSS1 R122H mutations in hereditary pancreatitis patients from Northern Germany. (18702646)
2008
6
Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series. (18184119)
2008
7
A novel mutation of PRSS1 gene in a Chinese hereditary pancreatitis family]. (17855255)
2007
8
Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. (17274009)
2007
9
Hereditary pancreatitis and secondary screening for early pancreatic cancer. (16358943)
2005
10
A case of R122H mutation of cationic trypsinogen gene in a pediatric patient with hereditary pancreatitis complicated by pseudocyst and hemosuccus pancreaticus]. (15725718)
2005
11
Hereditary pancreatitis--a rare differential diagnosis in patients with menstruation-associated recurrent acute pancreatitis: a case report. (15106365)
2004
12
Sporadic hereditary pancreatic desmoid tumor: a new entity? (12869894)
2003
13
Hereditary pancreatitis. (12508340)
2003
14
Gene symbol: Spink1-Omim 167790. Disease: hereditary pancreatitis. (12974284)
2003
15
Idiopathic vs hereditary pancreatitis. (12597745)
2003
16
The pathobiochemistry of hereditary pancreatitis: studies on recombinant human cationic trypsinogen. (12120225)
2001
17
Expression and penetrance of the hereditary pancreatitis phenotype in monozygotic twins. (11247900)
2001
18
A case of hemosuccus pancreaticus associated with hereditary pancreatitis. (11874252)
2001
19
Hereditary pancreatitis in North America: the Pittsburgh-Midwest Multi-Center Pancreatic Study Group Study. (12120221)
2001
20
Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene. (11755505)
2001
21
Origin and implication of the hereditary pancreatitis-associated N21I mutation in the cationic trypsinogen gene. (10982192)
2000
22
Nomenclature of trypsinogen mutations in hereditary pancreatitis. (10649497)
2000
23
Mutations of the cationic trypsinogen gene in patients with hereditary pancreatitis. (10671922)
2000
24
Re: Maternal inheritance pattern of hereditary pancreatitis in patients with pancreatic carcinoma. (10491444)
1999
25
Hereditary pancreatitis: new insights, new directions. (11030605)
1999
26
The First International Symposium on Hereditary Pancreatitis. (9888654)
1999
27
Mutations of the cationic trypsinogen in hereditary pancreatitis. (9633818)
1998
28
Hereditary pancreatitis and familial pancreatic cancer. (9438603)
1997
29
Hereditary pancreatitis. (9219774)
1997
30
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. (8841182)
1996
31
A gene for hereditary pancreatitis maps to chromosome 7q35. (8964426)
1996
32
Pancreas divisum in a family with hereditary pancreatitis. (8776088)
1996
33
Hereditary pancreatitis with lithiasis. (8613326)
1995
34
Hereditary pancreatitis. (8198107)
1994
35
Surgical management of hereditary pancreatitis: report of a case and presentation of a new family. (8022767)
1994
36
PRSS1-Related Hereditary Pancreatitis (22379635)
1993
37
Hereditary pancreatitis in a Chinese family. (2303690)
1990
38
Hereditary pancreatitis and recurrent abdominal pain of childhood. (4057022)
1985
39
Pancreatography in a family with hereditary pancreatitis. (3976423)
1985
40
Hereditary pancreatitis presenting in childhood: case report with family studies. (4062723)
1985
41
Idiopathic hereditary pancreatitis. (6848068)
1983
42
The diagnosis of hereditary pancreatitis by pancreatography. (7297825)
1981
43
Hereditary pancreatitis: morphological pictures (ERCP) in the youngest member of a family. (484175)
1979
44
Hereditary pancreatitis. Nonspecificity of aminoaciduria and diagnosis of occult disease. (1130928)
1975
45
Hereditary pancreatitis. Review and presentation of an additional kindred. (4808576)
1974
46
Hereditary pancreatitis: report of the first kindred in Italy. (4757781)
1973
47
Hereditary pancreatitis: report of a kindred. (4785562)
1973
48
Hereditary pancreatitis: three new kindreds and a critical review of the literature. (4567584)
1973
49
IgA synthesis by jejunal biopsies from patients with cystic fibrosis and hereditary pancreatitis. (4684447)
1973
50
Hereditary pancreatitis. A kindred without gross aminoaciduria. (5635333)
1968

Variations for Hereditary Pancreatitis

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Hereditary Pancreatitis:

65 (show all 25)
id Symbol AA change Variation ID SNP ID
1CTRCp.Ala73ThrVAR_043520
2CTRCp.Gly217ArgVAR_043522
3CTRCp.Gly217SerVAR_043523rs202058123
4CTRCp.Val235IleVAR_043527rs140993290
5CTRCp.Pro249LeuVAR_043528rs142560329
6CTRCp.Arg254TrpVAR_043529rs121909293
7CTRCp.Gly32ValVAR_070522
8CTRCp.Cys155TyrVAR_070526
9CTRCp.Gln178ArgVAR_070528rs200678111
10CTRCp.Val250GluVAR_070538
11PRSS1p.Asn29IleVAR_006720
12PRSS1p.Arg122HisVAR_006721
13PRSS1p.Asp22GlyVAR_011652
14PRSS1p.Lys23ArgVAR_011653
15PRSS1p.Leu104ProVAR_011654
16PRSS1p.Arg116CysVAR_011655
17PRSS1p.Cys139PheVAR_011656
18PRSS1p.Ala16ValVAR_011693
19PRSS1p.Asn29ThrVAR_012712
20PRSS1p.Arg122CysVAR_012713
21PRSS1p.Asn54SerVAR_037908
22PRSS1p.Glu79LysVAR_037909rs28934902
23SPINK1p.Leu14ProVAR_011688
24SPINK1p.Asn34SerVAR_011689rs17107315
25SPINK1p.Leu12PheVAR_032011rs35877720

Clinvar genetic disease variations for Hereditary Pancreatitis:

1 (show all 39)
id Gene Name Type Significance SNP ID Assembly Location
1NM_002769.4(PRSS1): c.365G> A (p.Arg122His)single nucleotide variantPathogenicrs111033565GRCh37Chr 7, 142459789: 142459789
2NM_002769.4(PRSS1): c.86A> T (p.Asn29Ile)single nucleotide variantPathogenicrs111033566GRCh37Chr 7, 142458451: 142458451
3NM_002769.4(PRSS1): c.68A> G (p.Lys23Arg)single nucleotide variantPathogenicrs111033567GRCh37Chr 7, 142458433: 142458433
4PRSS1PRSS1, 3-BP DELdeletionPathogenic
5NM_002769.4(PRSS1): c.235G> A (p.Glu79Lys)single nucleotide variantPathogenicrs111033564GRCh37Chr 7, 142459659: 142459659
6NM_002769.4(PRSS1): c.161A> G (p.Asn54Ser)single nucleotide variantPathogenicrs144422014GRCh37Chr 7, 142458526: 142458526
7NM_002769.4(PRSS1): c.365_366delGCinsAT (p.Arg122His)indelPathogenicrs267606982GRCh37Chr 7, 142459789: 142459790
8NM_002769.4(PRSS1): c.364C> T (p.Arg122Cys)single nucleotide variantPathogenicrs111033568GRCh37Chr 7, 142459788: 142459788
9PRSS1PRSS1, TRIPLICATIONundetermined variantPathogenic
10SPINK1SPINK1: c.194+2T> Csingle nucleotide variantPathogenicrs148954387GRCh38Chr 5, 147828020: 147828020
11SPINK1NM_003122.4(SPINK1): c.150T> G (p.Asp50Glu)single nucleotide variantPathogenicrs515726206GRCh38Chr 5, 147828066: 147828066
12SPINK1NM_003122.4(SPINK1): c.160T> C (p.Tyr54His)single nucleotide variantPathogenicrs515726207GRCh38Chr 5, 147828056: 147828056
13SPINK1NM_003122.4(SPINK1): c.199C> T (p.Arg67Cys)single nucleotide variantPathogenicrs515726208GRCh38Chr 5, 147824702: 147824702
14CFTRNM_000492.3(CFTR): c.54-5940_273+10250deldeletionPathogenicGRCh38Chr 7, 117498313: 117519392
15CFTRNM_000492.3(CFTR): c.3963-78_4242+577deldeletionPathogenicGRCh38Chr 7, 117652853: 117666141
16CTRCNM_007272.2(CTRC): c.217G> A (p.Ala73Thr)single nucleotide variantPathogenicrs515726209GRCh37Chr 1, 15767073: 15767073
17CTRCNM_007272.2(CTRC): c.738_761del24 (p.Lys247_Arg254del)deletionPathogenicrs515726210GRCh37Chr 1, 15772190: 15772213
18PRSS1NP_002760.1: p.Cys139Serprotein onlyPathogenic
19SPINK1NM_003122.4(SPINK1): c.101A> G (p.Asn34Ser)single nucleotide variantPathogenic, risk factorrs17107315GRCh37Chr 5, 147207678: 147207678
20SPINK1NM_003122.4(SPINK1): c.2T> C (p.Met1Thr)single nucleotide variantPathogenicrs104893938GRCh37Chr 5, 147211139: 147211139
21SPINK1SPINK1, -215G-Asingle nucleotide variantPathogenic
22SPINK1NM_003122.4(SPINK1): c.41T> C (p.Leu14Pro)single nucleotide variantPathogenicrs104893939GRCh37Chr 5, 147211100: 147211100
23SPINK1NM_003122.4(SPINK1): c.41T> G (p.Leu14Arg)single nucleotide variantPathogenicrs104893939GRCh37Chr 5, 147211100: 147211100
24SPINK1SPINK1, 1.3-KB DELdeletionPathogenic
25NM_002769.4(PRSS1): c.346C> T (p.Arg116Cys)single nucleotide variantPathogenicrs387906698GRCh37Chr 7, 142459770: 142459770
26CFTRNM_000492.3(CFTR): c.224G> A (p.Arg75Gln)single nucleotide variantBenign, Likely benign, Pathogenic, Uncertain significancers1800076GRCh37Chr 7, 117149147: 117149147
27SPINK1NM_003122.4(SPINK1): c.163C> T (p.Pro55Ser)single nucleotide variantBenign, Pathogenicrs111966833GRCh37Chr 5, 147207616: 147207616
28SPINK1NM_003122.4(SPINK1): c.27delC (p.Ser10Valfs)deletionLikely pathogenic, Pathogenicrs193922659GRCh37Chr 5, 147211114: 147211114
29NM_002769.4(PRSS1): c.116T> C (p.Val39Ala)single nucleotide variantPathogenicrs397507439GRCh37Chr 7, 142458481: 142458481
30NM_002769.4(PRSS1): c.415T> A (p.Cys139Ser)single nucleotide variantPathogenicrs397507440GRCh37Chr 7, 142459839: 142459839
31NM_002769.4(PRSS1): c.47C> T (p.Ala16Val)single nucleotide variantPathogenicrs202003805GRCh37Chr 7, 142458412: 142458412
32NM_002769.4(PRSS1): c.63_71dupTGACAAGAT (p.Ile24_Val25insAspLysIle)duplicationPathogenicrs397507441GRCh37Chr 7, 142458428: 142458436
33NM_002769.4(PRSS1): c.65A> G (p.Asp22Gly)single nucleotide variantPathogenicrs397507442GRCh37Chr 7, 142458430: 142458430
34NM_002769.4(PRSS1): c.86A> C (p.Asn29Thr)single nucleotide variantPathogenicrs111033566GRCh37Chr 7, 142458451: 142458451
35CFTRNM_000492.3(CFTR): c.1521_1523delCTT (p.Phe508delPhe)deletionPathogenic, risk factorrs113993960GRCh37Chr 7, 117199646: 117199648
36CFTRNM_000492.3(CFTR): c.1624G> T (p.Gly542Ter)single nucleotide variantPathogenicrs113993959GRCh37Chr 7, 117227832: 117227832
37CFTRNM_000492.3(CFTR): c.1652G> A (p.Gly551Asp)single nucleotide variantPathogenicrs75527207GRCh37Chr 7, 117227860: 117227860
38CTRCNM_007272.2(CTRC): c.760C> T (p.Arg254Trp)single nucleotide variantPathogenic, risk factorrs121909293GRCh37Chr 1, 15772212: 15772212
39CTRCNM_007272.2(CTRC): c.164G> A (p.Trp55Ter)single nucleotide variantPathogenic, risk factorrs121909294GRCh37Chr 1, 15767020: 15767020

Expression for genes affiliated with Hereditary Pancreatitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hereditary Pancreatitis

Search GEO for disease gene expression data for Hereditary Pancreatitis.

Pathways for genes affiliated with Hereditary Pancreatitis

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Sources:
51PathCards, 31KEGG, 52PharmGKB, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database
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Pathways related to Hereditary Pancreatitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CFTR, PRSS1, PRSS2
29.7GSTT1, GSTP1
39.3GSTT1, GSTP1, GSTM1
4
Show member pathways
9.1SOD1, GSR, GSTP1
5
Show member pathways
Signaling Pathways in Glioblastoma39
9.1CDKN2A, GSTP1, BRCA2
68.7SOD1, GSTM1, GSTP1, GSTT1
78.7GSR, SOD1, MGST1
8
Show member pathways
8.6SOD1, GSR, GSTP1, CDKN2A
9
Show member pathways
8.3MGST1, GSTM3, GSTM1, GSTP1, GSTT1
10
Show member pathways
7.9MGST1, GSTM3, GSR, GSTM1, GSTP1, GSTT1
11
Show member pathways
glutathione-mediated detoxification I39
glutathione redox reactions I39
glutathione redox reactions II39
4-hydroxy-2-nonenal detoxification39
Glutathione metabolism61
Glutathione metabolism39
7.9GSTT1, GSTP1, GSTM1, GSR, GSTM3, MGST1
12
Show member pathways
7.7MGST1, PRSS1, GSTM3, GSR, GSTM1, GSTP1

Compounds for genes affiliated with Hereditary Pancreatitis

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Sources:
46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Hereditary Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 149)
idCompoundScoreTop Affiliating Genes
1methylchloride469.7GSTM1, GSTT1, GSTP1
2s-phenylmercapturic acid469.6GSTP1, GSTM1, GSTT1
31,3-butadiene469.6GSTP1, GSTM1, GSTT1
4cumene hydroperoxide469.4GSTT1, GSTP1, GSTM1, GSR
51-hydroxypyrene469.4GSTM1, GSTT1, GSTP1
6acetone469.4GSTP1, GSR, GSTM1, GSTT1
7styrene469.3GSTP1, GSTT1, GSTM1
8trichloroethylene469.2GSTT1, GSTP1, GSTM1
9bcnu469.2CDKN2A, GSR, GSTP1, GSTT1
10glutathion469.1GSTP1, GSTM1, SOD1, GSR
11gsno469.1CFTR, SOD1, GSR, GSTP1
12gssg469.1SOD1, GSTP1, GSTM1, GSR
13lycopene46 2510.0GSR, BRCA2, SOD1, GSTP1
14cyclophosphamide46 52 1211.0GSR, GSTP1, GSTT1, GSTM3, GSTM1
15malondialdehyde468.9SOD1, GSR, GSTM1, GSTT1
16chlorambucil46 129.9GSTM1, GSTP1, GSR, MGST1
17oxaliplatin46 52 1210.9GSTM1, GSTT1, SOD1, GSTP1
181-chloro-24-dinitrobenzene468.9MGST1, GSTM1, GSTP1, GSTT1
19manganese superoxide468.8SOD1, GSR, GSTM1, GSTP1, GSTT1
204-hydroxynonenal46 259.7GSTP1, GSR, SOD1, GSTM1
21carboplatin46 52 1210.7SOD1, GSR, GSTM1, GSTT1, GSTP1
224-Hydroxyestrone-2-S-glutathione258.7GSTT1, GSTP1, GSTM1, GSTM3, MGST1
23noradrenochrome46 259.7MGST1, GSTM3, GSTM1, GSTP1, GSTT1
24S-(PGJ2)-glutathione258.7MGST1, GSTT1, GSTP1, GSTM1, GSTM3
252-Hydroxyestrone-1-S-glutathione258.7GSTT1, GSTM1, GSTP1, GSTM3, MGST1
26Estrone-3,4-quinone258.7MGST1, GSTM3, GSTM1, GSTP1, GSTT1
27Estrone-2,3-quinone258.7MGST1, GSTM3, GSTM1, GSTT1, GSTP1
282-Hydroxyestrone-4-S-glutathione258.7GSTT1, GSTP1, GSTM1, GSTM3, MGST1
29hydrochloric acid46 259.7GSTM1, GSTP1, GSTT1, MGST1, GSTM3
30valine468.7CDKN2A, GSTT1, GSTP1, GSTM1, CTSB, CFTR
31epoxide468.7MGST1, GSTM3, GSTM1, GSTP1, GSTT1
32methotrexate52 46 1210.5BRCA2, GSTM1, CDKN2A, GSR, GSTP1
33sulfate46 259.5GSTM1, GSTP1, GSTM3, MGST1, GSTT1
34ascorbic acid46 259.5GSR, GSTP1, GSTT1, SOD1, CFTR, GSTM1
35folate468.4BRCA2, GSR, GSTM1, GSTP1, GSTT1, CDKN2A
36adriamycin468.4SOD1, GSR, GSTP1, CDKN2A, BRCA2
37gsts468.4GSTT1, MGST1, GSTM3, GSTM1, GSR, GSTP1
38Glutathione25 129.4GSTP1, GSTM3, GSTM1, GSR, MGST1, GSTT1
39doxorubicin46 52 1210.3GSTM1, GSTT1, CFTR, CTSB, GSR, GSTP1
40trypsinogen468.2BRCA2, CFTR, TMPRSS15, REG1A, SPINK1, PRSS1
41genistein46 30 62 3 25 1213.2GSTP1, GSR, REG1A, BRCA2, CFTR, CDKN2A
42adrenochrome46 259.1MGST1, GSTT1, GSTP1, GSTM1, GSTM3, SOD1
43creatinine467.8GSTP1, GSTM1, GSTT1, SOD1, SPINK1, CDKN2A
44serine467.6CTRC, TMPRSS15, SPINK1, PRSS2, CFTR, CDKN2A
45oxygen46 258.4CDKN2A, SOD1, GSR, CTSB, GSTM1, GSTT1
46estrogen467.1CTSB, MGST1, CFTR, GSTM1, GSR, CDKN2A
47cisplatin46 52 62 1210.1GSTM3, SOD1, BRCA2, GSR, CTSB, GSTP1
48h2o2466.8BRCA2, GSTM1, CFTR, GSTP1, MGST1, SOD1
49cysteine466.8GSTM1, MGST1, SOD1, PRSS1, PRSS2, CFTR
50arginine466.7CDKN2A, CTSB, GSTT1, GSTP1, GSTM1, GSR

GO Terms for genes affiliated with Hereditary Pancreatitis

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Sources:
17Gene Ontology
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Cellular components related to Hereditary Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.6CDKN2A, BRCA2, SOD1, CFTR
2extracellular regionGO:0055768.2SPINK1, SOD1, PRSS1, PRSS2, REG1A, CTSB
3mitochondrionGO:0057397.8CTSB, CDKN2A, GSTP1, SOD1, MGST1
4cytosolGO:0058297.3SOD1, GSTM3, GSR, GSTM1, GSTP1, GSTT1

Biological processes related to Hereditary Pancreatitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cellular detoxification of nitrogen compoundGO:07045810.0GSTM3, GSTM1
2nitrobenzene metabolic processGO:01891610.0GSTM3, GSTM1
3xenobiotic catabolic processGO:0421789.9GSTM1, GSTM3
4proteolysisGO:0065089.7CTSB, CTRC, PRSS2
5extracellular matrix disassemblyGO:0226179.6CTSB, PRSS2, PRSS1
6positive regulation of superoxide anion generationGO:0329309.6GSTP1, SOD1
7cell agingGO:0075699.1SOD1, BRCA2
8xenobiotic metabolic processGO:0068058.9GSTT1, GSTM1, GSTM3, MGST1
9glutathione derivative biosynthetic processGO:19016878.5MGST1, GSTM3, GSTM1, GSTP1, GSTT1
10response to drugGO:0424938.4MGST1, CFTR, SOD1, GSTT1
11small molecule metabolic processGO:0442817.9MGST1, PRSS1, GSTM3, GSR, GSTM1, GSTP1
12glutathione metabolic processGO:0067497.6GSTT1, GSTP1, GSTM1, GSR, GSTM3, SOD1

Molecular functions related to Hereditary Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione peroxidase activityGO:0046029.3GSTT1, MGST1
2serine-type endopeptidase activityGO:0042529.2CTRC, PRSS2, PRSS1, TMPRSS15
3glutathione bindingGO:0432958.9MGST1, GSTM3, GSTM1
4glutathione transferase activityGO:0043648.3GSTT1, GSTP1, GSTM1, GSTM3, MGST1

Products for genes affiliated with Hereditary Pancreatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hereditary Pancreatitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet