HP
MCID: HRD057
MIFTS: 66

Hereditary Pancreatitis (HP) malady

Genetic diseases, Rare diseases, Endocrine diseases, Gastrointestinal diseases, Bone diseases, Immune diseases categories
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Summaries for Hereditary Pancreatitis

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CDC:3 Infection with hantavirus can progress to Hantavirus Pulmonary Syndrome (HPS), which can be fatal. People become infected through contact with hantavirus-infected rodents or their urine and droppings. The Sin Nombre hantavirus, first recognized in 1993, is one of several New World hantaviruses circulating in the US. Old World hantaviruses, found in Asia, can cause Hemorrhagic Fever with Renal Syndrome (HFRS). Rodent control in and around the home remains the primary strategy for preventing hantavirus infection. All cases of Hantavirus infection are reported to the CDC.

MalaCards based summary: Hereditary Pancreatitis, also known as autosomal dominant hereditary pancreatitis, is related to pancreatic cancer and alcoholic pancreatitis. An important gene associated with Hereditary Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Pancreatic secretion and Etoposide Pathway, Pharmacokinetics/Pharmacodynamics. The compounds methylchloride and s-phenylmercapturic acid have been mentioned in the context of this disorder. Affiliated tissues include pancreas and testes, and related mouse phenotypes are tumorigenesis and integument.

Genetics Home Reference:21 Hereditary pancreatitis is a genetic condition characterized by recurrent episodes of inflammation of the pancreas (pancreatitis). The pancreas produces enzymes that help digest food, and it also produces insulin, a hormone that controls blood sugar levels in the body. Episodes of pancreatitis can lead to permanent tissue damage and loss of pancreatic function.

Wikipedia:65 Hereditary pancreatitis (HP) is an inflammation of the pancreas, attributed to genetic causes. It was... more...

Description from OMIM:46 167800

Aliases & Classifications for Hereditary Pancreatitis

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Hereditary Pancreatitis, Aliases & Descriptions:

Name: Hereditary Pancreatitis 42 20 22 21 62
Autosomal Dominant Hereditary Pancreatitis 21 62
Hereditary Chronic Pancreatitis 21 62
Familial Pancreatitis 21 62
 
Pancreatitis, Hereditary 46
Pancreatitis Hereditary 44
Hp 21


Classifications:



Related Diseases for Hereditary Pancreatitis

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Diseases in the Hereditary Pancreatitis family:

Acute Pancreatitis Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Pancreatitis, Chronic
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Hereditary Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic cancer30.9BRCA2, SPINK1, CDKN2A
2alcoholic pancreatitis30.8SPINK1, CFTR
3methemoglobinemia30.8GSR
4pancreatitis30.7SPINK1, CTSB, CTRC, REG1A, PRSS2, PRSS1
5cystic fibrosis30.6SPINK1, GSTM1, PRSS1, CFTR
6recurrent acute pancreatitis30.3CFTR, SOD1, SPINK1
7lung cancer30.1GSTP1, GSTM1, CDKN2A
8diabetes mellitus29.9REG1A, SOD1, SPINK1, GSR
9acute pancreatitis29.7CFTR, SPINK1, TMPRSS15, SOD1, REG1A, CTSB
10pancreatitis, chronic29.7SOD1, REG1A, GSTT1, PRSS1, TMPRSS15, CFTR
11melanoma29.6CDKN2A, CFTR, BRCA2, CTSB, GSTT1
12adenocarcinoma29.3GSTT1, GSTP1, REG1A, CDKN2A, CTSB, GSTM1
13tropical calcific pancreatitis10.6SPINK1
14hermansky-pudlak syndrome10.5
15hantavirus pulmonary syndrome10.5
16diabetic cataract10.5GSR
17steatorrhea10.5TMPRSS15, CFTR
18anhaptoglobinemia10.4
19brain cancer10.4GSTM1, GSTT1
20asbestosis10.3GSTM1, GSTT1
21malaria10.3
22artery disease10.3
23open-angle glaucoma10.3GSTT1, GSTM1
24pancreas disease10.3REG1A, SPINK1, CFTR, TMPRSS15
25pancreatic carcinoma, familial10.3
26atypical mole syndrome10.3BRCA2, CDKN2A
27prss1-related hereditary pancreatitis10.3
28infertility10.3CFTR, SPINK1, GSTT1
29acute myeloid leukemia, adult10.3GSTM1, GSTT1
30schistosomiasis10.3CTSB, GSTM1, GSR
31basal cell carcinoma10.2GSTM3, GSTM1, GSTT1
32familial colorectal cancer10.2BRCA2, CDKN2A
33leukoplakia10.2GSTM1, GSTT1
34li-fraumeni syndrome10.2CDKN2A, BRCA2
35diabetic nephropathy10.2
36pulmonary tuberculosis10.2
37plasmodium falciparum malaria10.2
38hemoglobinuria10.2
39autoimmune hemolytic anemia10.2
40favism10.2
41hellp syndrome10.2
42mastitis10.2
43tuberculosis10.2
44cluster headache10.2
45hermansky-pudlak syndrome 110.2
46headache10.2
47esophageal cancer10.2CDKN2A, GSTP1, SPINK1
48hepatitis c10.2GSR, CTSB, PRSS1, GSTM1
49extrinsic allergic alveolitis10.2
50bladder carcinoma in situ10.1CDKN2A, GSTP1, GSTM1

Graphical network of the top 20 diseases related to Hereditary Pancreatitis:



Diseases related to hereditary pancreatitis

Symptoms for Hereditary Pancreatitis

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Clinical features from OMIM:

167800

Drugs & Therapeutics for Hereditary Pancreatitis

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Drug clinical trials:

Search ClinicalTrials for Hereditary Pancreatitis

Search NIH Clinical Center for Hereditary Pancreatitis

Genetic Tests for Hereditary Pancreatitis

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Genetic tests related to Hereditary Pancreatitis:

id Genetic test Affiliating Genes
1 Hereditary Pancreatitis20 22 SPINK1

Anatomical Context for Hereditary Pancreatitis

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MalaCards organs/tissues related to Hereditary Pancreatitis:

32
Pancreas, Testes

Animal Models for Hereditary Pancreatitis or affiliated genes

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MGI Mouse Phenotypes related to Hereditary Pancreatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5BRCA2, FAH, GSTP1, CDKN2A, CTSB
2MP:00107718.4MPV17, BRCA2, GSTP1, CDKN2A, CTSB, SPINK1
3MP:00053787.6SPINK1, CFTR, MPV17, BRCA2, FAH, GSTP1
4MP:00053847.5CFTR, MPV17, SOD1, BRCA2, FAH, GSTM1
5MP:00053797.3SPINK1, CFTR, MPV17, SOD1, BRCA2, FAH
6MP:00053766.1CTSB, SPINK1, CFTR, C6, MPV17, TMPRSS15

Publications for Hereditary Pancreatitis

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Articles related to Hereditary Pancreatitis:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
The histopathology of PRSS1 hereditary pancreatitis. (24525505)
2014
2
Genetic, epidemiological, and clinical aspects of hereditary pancreatitis: a population-based cohort study in Denmark. (20502448)
2010
3
Comments on hereditary pancreatitis. (19592702)
2009
4
Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (19690177)
2009
5
Mortality rate and risk factors in patients with hereditary pancreatitis: uni- and multidimensional analyses. (19550412)
2009
6
Local clustering of PRSS1 R122H mutations in hereditary pancreatitis patients from Northern Germany. (18702646)
2008
7
Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series. (18184119)
2008
8
A novel mutation of PRSS1 gene in a Chinese hereditary pancreatitis family]. (17855255)
2007
9
Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. (17274009)
2007
10
Hereditary pancreatitis and secondary screening for early pancreatic cancer. (16358943)
2005
11
A case of R122H mutation of cationic trypsinogen gene in a pediatric patient with hereditary pancreatitis complicated by pseudocyst and hemosuccus pancreaticus]. (15725718)
2005
12
Hereditary pancreatitis--a rare differential diagnosis in patients with menstruation-associated recurrent acute pancreatitis: a case report. (15106365)
2004
13
Sporadic hereditary pancreatic desmoid tumor: a new entity? (12869894)
2003
14
Hereditary pancreatitis. (12508340)
2003
15
Gene symbol: Spink1-Omim 167790. Disease: hereditary pancreatitis. (12974284)
2003
16
Idiopathic vs hereditary pancreatitis. (12597745)
2003
17
The pathobiochemistry of hereditary pancreatitis: studies on recombinant human cationic trypsinogen. (12120225)
2001
18
Expression and penetrance of the hereditary pancreatitis phenotype in monozygotic twins. (11247900)
2001
19
A case of hemosuccus pancreaticus associated with hereditary pancreatitis. (11874252)
2001
20
Hereditary pancreatitis in North America: the Pittsburgh-Midwest Multi-Center Pancreatic Study Group Study. (12120221)
2001
21
Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene. (11755505)
2001
22
Origin and implication of the hereditary pancreatitis-associated N21I mutation in the cationic trypsinogen gene. (10982192)
2000
23
Nomenclature of trypsinogen mutations in hereditary pancreatitis. (10649497)
2000
24
Mutations of the cationic trypsinogen gene in patients with hereditary pancreatitis. (10671922)
2000
25
Re: Maternal inheritance pattern of hereditary pancreatitis in patients with pancreatic carcinoma. (10491444)
1999
26
Hereditary pancreatitis: new insights, new directions. (11030605)
1999
27
The First International Symposium on Hereditary Pancreatitis. (9888654)
1999
28
Mutations of the cationic trypsinogen in hereditary pancreatitis. (9633818)
1998
29
Hereditary pancreatitis and familial pancreatic cancer. (9438603)
1997
30
Hereditary pancreatitis. (9219774)
1997
31
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. (8841182)
1996
32
A gene for hereditary pancreatitis maps to chromosome 7q35. (8964426)
1996
33
Hereditary pancreatitis with lithiasis. (8613326)
1995
34
Hereditary pancreatitis. (8198107)
1994
35
PRSS1-Related Hereditary Pancreatitis (22379635)
1993
36
Hereditary pancreatitis in a Chinese family. (2303690)
1990
37
Hereditary pancreatitis and recurrent abdominal pain of childhood. (4057022)
1985
38
Pancreatography in a family with hereditary pancreatitis. (3976423)
1985
39
Hereditary pancreatitis presenting in childhood: case report with family studies. (4062723)
1985
40
Idiopathic hereditary pancreatitis. (6848068)
1983
41
The diagnosis of hereditary pancreatitis by pancreatography. (7297825)
1981
42
Hereditary pancreatitis: morphological pictures (ERCP) in the youngest member of a family. (484175)
1979
43
Hereditary pancreatitis. Nonspecificity of aminoaciduria and diagnosis of occult disease. (1130928)
1975
44
Hereditary pancreatitis. Review and presentation of an additional kindred. (4808576)
1974
45
Hereditary pancreatitis: report of the first kindred in Italy. (4757781)
1973
46
Surgical treatment of hereditary pancreatitis: report of a case. (4714086)
1973
47
Hereditary pancreatitis: report of a kindred. (4785562)
1973
48
Hereditary pancreatitis: three new kindreds and a critical review of the literature. (4567584)
1973
49
IgA synthesis by jejunal biopsies from patients with cystic fibrosis and hereditary pancreatitis. (4684447)
1973
50
Hereditary pancreatitis. A kindred without gross aminoaciduria. (5635333)
1968

Variations for Hereditary Pancreatitis

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UniProtKB/Swiss-Prot genetic disease variations for Hereditary Pancreatitis:

64 (show all 25)
id Symbol AA change Variation ID SNP ID
1CTRCp.Ala73ThrVAR_043520
2CTRCp.Gly217ArgVAR_043522
3CTRCp.Gly217SerVAR_043523rs202058123
4CTRCp.Val235IleVAR_043527rs140993290
5CTRCp.Pro249LeuVAR_043528rs142560329
6CTRCp.Arg254TrpVAR_043529rs121909293
7CTRCp.Gly32ValVAR_070522
8CTRCp.Cys155TyrVAR_070526
9CTRCp.Gln178ArgVAR_070528rs200678111
10CTRCp.Val250GluVAR_070538
11PRSS1p.Asn29IleVAR_006720
12PRSS1p.Arg122HisVAR_006721
13PRSS1p.Asp22GlyVAR_011652
14PRSS1p.Lys23ArgVAR_011653
15PRSS1p.Leu104ProVAR_011654
16PRSS1p.Arg116CysVAR_011655
17PRSS1p.Cys139PheVAR_011656
18PRSS1p.Ala16ValVAR_011693
19PRSS1p.Asn29ThrVAR_012712
20PRSS1p.Arg122CysVAR_012713
21PRSS1p.Asn54SerVAR_037908
22PRSS1p.Glu79LysVAR_037909rs28934902
23SPINK1p.Leu14ProVAR_011688
24SPINK1p.Asn34SerVAR_011689rs17107315
25SPINK1p.Leu12PheVAR_032011rs35877720

Clinvar genetic disease variations for Hereditary Pancreatitis:

6 (show all 40)
id Gene Name Type Significance SNP ID Assembly Location
1NM_002769.4(PRSS1): c.365G> A (p.Arg122His)single nucleotide variantPathogenicrs111033565GRCh37Chr 7, 142459789: 142459789
2NM_002769.4(PRSS1): c.86A> T (p.Asn29Ile)single nucleotide variantPathogenicrs111033566GRCh37Chr 7, 142458451: 142458451
3NM_002769.4(PRSS1): c.68A> G (p.Lys23Arg)single nucleotide variantPathogenicrs111033567GRCh37Chr 7, 142458433: 142458433
4PRSS1PRSS1, 3-BP DELdeletionPathogenic
5NM_002769.4(PRSS1): c.235G> A (p.Glu79Lys)single nucleotide variantPathogenicrs111033564GRCh37Chr 7, 142459659: 142459659
6NM_002769.4(PRSS1): c.161A> G (p.Asn54Ser)single nucleotide variantPathogenicrs144422014GRCh37Chr 7, 142458526: 142458526
7NM_002769.4(PRSS1): c.365_366delGCinsAT (p.Arg122His)indelPathogenicrs267606982GRCh37Chr 7, 142459789: 142459790
8NM_002769.4(PRSS1): c.364C> T (p.Arg122Cys)single nucleotide variantPathogenicrs111033568GRCh37Chr 7, 142459788: 142459788
9PRSS1PRSS1, TRIPLICATIONundetermined variantPathogenic
10SPINK1SPINK1: c.194+2T> Csingle nucleotide variantPathogenicrs148954387GRCh38Chr 5, 147828020: 147828020
11SPINK1NM_003122.4(SPINK1): c.150T> G (p.Asp50Glu)single nucleotide variantPathogenicrs515726206GRCh38Chr 5, 147828066: 147828066
12SPINK1NM_003122.4(SPINK1): c.160T> C (p.Tyr54His)single nucleotide variantPathogenicrs515726207GRCh38Chr 5, 147828056: 147828056
13SPINK1NM_003122.4(SPINK1): c.199C> T (p.Arg67Cys)single nucleotide variantPathogenicrs515726208GRCh38Chr 5, 147824702: 147824702
14CFTRNM_000492.3(CFTR): c.54-5940_273+10250deldeletionPathogenicGRCh38Chr 7, 117498313: 117519392
15CFTRNM_000492.3(CFTR): c.3963-78_4242+577deldeletionPathogenicGRCh38Chr 7, 117652853: 117666141
16CTRCNM_007272.2(CTRC): c.217G> A (p.Ala73Thr)single nucleotide variantPathogenicrs515726209GRCh37Chr 1, 15767073: 15767073
17CTRCNM_007272.2(CTRC): c.738_761del24 (p.Lys247_Arg254del)deletionPathogenicrs515726210GRCh37Chr 1, 15772190: 15772213
18PRSS1NP_002760.1: p.Cys139Serprotein onlyPathogenic
19SPINK1NM_003122.4(SPINK1): c.101A> G (p.Asn34Ser)single nucleotide variantPathogenicrs17107315GRCh37Chr 5, 147207678: 147207678
20SPINK1NM_003122.4(SPINK1): c.2T> C (p.Met1Thr)single nucleotide variantPathogenicrs104893938GRCh37Chr 5, 147211139: 147211139
21SPINK1SPINK1, -215G-Asingle nucleotide variantPathogenic
22SPINK1NM_003122.4(SPINK1): c.41T> C (p.Leu14Pro)single nucleotide variantPathogenicrs104893939GRCh37Chr 5, 147211100: 147211100
23SPINK1NM_003122.4(SPINK1): c.41T> G (p.Leu14Arg)single nucleotide variantPathogenicrs104893939GRCh37Chr 5, 147211100: 147211100
24SPINK1SPINK1, 1.3-KB DELdeletionPathogenic
25NM_002769.4(PRSS1): c.346C> T (p.Arg116Cys)single nucleotide variantPathogenicrs387906698GRCh37Chr 7, 142459770: 142459770
26NM_002769.4(PRSS1): c.389C> T (p.Thr130Ile)single nucleotide variantLikely pathogenicrs193922655GRCh37Chr 7, 142459813: 142459813
27NM_002769.4(PRSS1): c.398C> G (p.Pro133Arg)single nucleotide variantLikely pathogenicrs193922656GRCh37Chr 7, 142459822: 142459822
28SPINK1NM_003122.4(SPINK1): c.163C> T (p.Pro55Ser)single nucleotide variantPathogenicrs111966833GRCh37Chr 5, 147207616: 147207616
29SPINK1NM_003122.4(SPINK1): c.27delC (p.Ser10Valfs)deletionLikely pathogenicrs193922659GRCh37Chr 5, 147211114: 147211114
30NM_002769.4(PRSS1): c.116T> C (p.Val39Ala)single nucleotide variantPathogenicrs397507439GRCh37Chr 7, 142458481: 142458481
31NM_002769.4(PRSS1): c.415T> A (p.Cys139Ser)single nucleotide variantPathogenicrs397507440GRCh37Chr 7, 142459839: 142459839
32NM_002769.4(PRSS1): c.47C> T (p.Ala16Val)single nucleotide variantPathogenicrs202003805GRCh37Chr 7, 142458412: 142458412
33NM_002769.4(PRSS1): c.63_71dupTGACAAGAT (p.Ile24_Val25insAspLysIle)duplicationPathogenicrs397507441GRCh37Chr 7, 142458428: 142458436
34NM_002769.4(PRSS1): c.65A> G (p.Asp22Gly)single nucleotide variantPathogenicrs397507442GRCh37Chr 7, 142458430: 142458430
35NM_002769.4(PRSS1): c.86A> C (p.Asn29Thr)single nucleotide variantPathogenicrs111033566GRCh37Chr 7, 142458451: 142458451
36CFTRNM_000492.3(CFTR): c.1521_1523delCTT (p.Phe508delPhe)deletionPathogenicrs113993960GRCh37Chr 7, 117199646: 117199648
37CFTRNM_000492.3(CFTR): c.1624G> T (p.Gly542Ter)single nucleotide variantPathogenicrs113993959GRCh37Chr 7, 117227832: 117227832
38CFTRNM_000492.3(CFTR): c.1652G> A (p.Gly551Asp)single nucleotide variantPathogenicrs75527207GRCh37Chr 7, 117227860: 117227860
39CTRCNM_007272.2(CTRC): c.760C> T (p.Arg254Trp)single nucleotide variantPathogenicrs121909293GRCh37Chr 1, 15772212: 15772212
40CTRCNM_007272.2(CTRC): c.164G> A (p.Trp55Ter)single nucleotide variantPathogenicrs121909294GRCh37Chr 1, 15767020: 15767020

Expression for genes affiliated with Hereditary Pancreatitis

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Expression patterns in normal tissues for genes affiliated with Hereditary Pancreatitis

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Pathways for genes affiliated with Hereditary Pancreatitis

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Pathways related to Hereditary Pancreatitis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PRSS2, CFTR, PRSS1
29.7GSTT1, GSTP1
39.3GSTP1, GSTM1, GSTT1
4
Show member pathways
9.1SOD1, GSR, GSTP1
58.7SOD1, GSTM1, GSTP1, GSTT1
68.7MGST1, SOD1, GSR
7
Show member pathways
8.6GSR, SOD1, CDKN2A, GSTP1
8
Show member pathways
8.3MGST1, GSTM3, GSTM1, GSTP1, GSTT1
9
Show member pathways
glutathione-mediated detoxification I37
glutathione redox reactions I37
glutathione redox reactions II37
4-hydroxy-2-nonenal detoxification37
Glutathione metabolism60
Glutathione metabolism37
7.9GSTP1, MGST1, GSTM3, GSR, GSTM1, GSTT1
10
Show member pathways
7.9GSTT1, GSTP1, GSTM1, GSR, GSTM3, MGST1
11
Show member pathways
7.5GSTM3, PRSS1, FAH, GSTM1, GSR, GSTP1

Compounds for genes affiliated with Hereditary Pancreatitis

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Compounds related to Hereditary Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1methylchloride449.7GSTM1, GSTT1, GSTP1
2s-phenylmercapturic acid449.6GSTT1, GSTP1, GSTM1
31,3-butadiene449.5GSTP1, GSTM1, GSTT1
4cumene hydroperoxide449.4GSTP1, GSTM1, GSTT1, GSR
51-hydroxypyrene449.4GSTT1, GSTM1, GSTP1
6acetone449.4GSR, GSTT1, GSTM1, GSTP1
7styrene449.3GSTM1, GSTP1, GSTT1
8trichloroethylene449.3GSTM1, GSTP1, GSTT1
9mspi449.3GSTT1, BRCA2, FAH, GSTM1
10bcnu449.2GSR, GSTT1, CDKN2A, GSTP1
11glutathion449.2GSTM1, GSR, GSTP1, SOD1
12gsno449.2GSTP1, SOD1, CFTR, GSR
13gssg449.1GSTP1, GSTM1, SOD1, GSR
14lycopene44 2410.0GSTP1, GSR, BRCA2, SOD1
15cyclophosphamide44 50 1110.9GSTP1, GSTM3, GSR, GSTM1, GSTT1
161-chloro-24-dinitrobenzene448.9MGST1, GSTM1, GSTT1, GSTP1
17chlorambucil44 119.9GSR, MGST1, GSTM1, GSTP1
18oxaliplatin44 50 1110.8SOD1, GSTM1, GSTP1, GSTT1
19manganese superoxide448.8SOD1, GSR, GSTM1, GSTT1, GSTP1
20carboplatin44 50 1110.7SOD1, GSTP1, GSTT1, GSTM1, GSR
21malondialdehyde448.7GSTT1, GSTM1, GSR, SOD1
222-Hydroxyestrone-4-S-glutathione248.7GSTT1, GSTP1, GSTM1, GSTM3, MGST1
234-Hydroxyestrone-2-S-glutathione248.7GSTM1, GSTT1, GSTP1, GSTM3, MGST1
242-Hydroxyestrone-1-S-glutathione248.7MGST1, GSTM3, GSTT1, GSTM1, GSTP1
25S-(PGJ2)-glutathione248.7GSTM3, GSTM1, GSTT1, MGST1, GSTP1
26noradrenochrome44 249.7GSTM1, GSTP1, GSTT1, MGST1, GSTM3
27Estrone-2,3-quinone248.7GSTT1, GSTP1, MGST1, GSTM3, GSTM1
28Estrone-3,4-quinone248.7MGST1, GSTM3, GSTM1, GSTP1, GSTT1
29hydrochloric acid44 249.7MGST1, GSTT1, GSTM3, GSTP1, GSTM1
30valine448.7CTSB, GSTM1, CFTR, GSTP1, CDKN2A, GSTT1
31epoxide448.6GSTT1, GSTM3, MGST1, GSTM1, GSTP1
32sulfate44 249.5GSTT1, MGST1, GSTM3, GSTM1, GSTP1
33ascorbic acid44 249.5GSTT1, SOD1, GSTM1, GSTP1, CFTR, GSR
34folate448.4CDKN2A, GSTM1, GSR, BRCA2, GSTT1, GSTP1
35adriamycin448.4GSR, SOD1, BRCA2, CDKN2A, GSTP1
36gsts448.4MGST1, GSTT1, GSTP1, GSTM1, GSR, GSTM3
37Glutathione24 119.4GSR, MGST1, GSTM3, GSTT1, GSTM1, GSTP1
38doxorubicin44 50 1110.4CFTR, GSR, GSTM1, GSTP1, GSTT1, CTSB
39trypsinogen448.3CTSB, PRSS1, SPINK1, CFTR, TMPRSS15, BRCA2
40genistein44 28 61 2 24 1113.2CDKN2A, GSR, GSTP1, CFTR, BRCA2, REG1A
41methotrexate50 44 1110.1BRCA2, CDKN2A, GSTM1, GSTP1, GSR
42adrenochrome44 249.1GSTT1, GSTP1, MGST1, GSTM1, GSTM3, SOD1
43creatinine447.8CDKN2A, CTSB, GSTT1, GSTP1, GSTM1, GSR
44oxygen44 248.7GSTT1, SOD1, GSR, GSTM1, MPV17, CTSB
45serine447.6PRSS1, FAH, TMPRSS15, CFTR, SPINK1, GSTP1
46cisplatin44 50 61 1110.1GSR, CTSB, CDKN2A, GSTT1, GSTM1, CFTR
47estrogen447.1BRCA2, CFTR, CDKN2A, GSR, GSTM1, GSTP1
48cysteine446.9MGST1, CFTR, SOD1, PRSS1, GSTP1, CTSB
49h2o2446.9GSTP1, MGST1, CTSB, CDKN2A, GSTM1, GSR
50arginine446.7GSTP1, GSTT1, MGST1, CTSB, GSTM1, GSR

GO Terms for genes affiliated with Hereditary Pancreatitis

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Cellular components related to Hereditary Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.6SOD1, BRCA2, CDKN2A, CFTR
2extracellular regionGO:0055768.2CTSB, SPINK1, C6, SOD1, PRSS1, PRSS2
3cytosolGO:0058297.4GSTM1, GSR, GSTP1, FAH, SOD1, GSTT1
4mitochondrionGO:0057397.3MPV17, CTSB, CDKN2A, GSTP1, MGST1, SOD1

Biological processes related to Hereditary Pancreatitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cellular detoxification of nitrogen compoundGO:07045810.0GSTM3, GSTM1
2nitrobenzene metabolic processGO:0189169.9GSTM3, GSTM1
3xenobiotic catabolic processGO:0421789.9GSTM3, GSTM1
4positive regulation of superoxide anion generationGO:0329309.4SOD1, GSTP1
5extracellular matrix disassemblyGO:0226179.4CTSB, PRSS2, PRSS1
6cell agingGO:0075699.4BRCA2, SOD1
7xenobiotic metabolic processGO:0068058.9MGST1, GSTM3, GSTM1, GSTT1
8glutathione derivative biosynthetic processGO:19016878.5MGST1, GSTM3, GSTM1, GSTP1, GSTT1
9response to drugGO:0424938.4MGST1, CFTR, SOD1, GSTT1
10small molecule metabolic processGO:0442817.7MGST1, FAH, PRSS1, GSTM3, GSR, GSTM1
11glutathione metabolic processGO:0067497.6GSTT1, GSTP1, GSTM1, GSR, GSTM3, SOD1

Molecular functions related to Hereditary Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione peroxidase activityGO:0046029.3GSTT1, MGST1
2serine-type endopeptidase activityGO:0042529.2CTRC, PRSS2, PRSS1, TMPRSS15
3glutathione bindingGO:0432958.9MGST1, GSTM3, GSTM1
4glutathione transferase activityGO:0043648.3GSTT1, GSTP1, GSTM1, GSTM3, MGST1

Products for genes affiliated with Hereditary Pancreatitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hereditary Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet