MCID: HRD031
MIFTS: 45

Hereditary Paraganglioma-Pheochromocytoma Syndromes

Categories: Rare diseases, Genetic diseases, Cardiovascular diseases, Nephrological diseases, Endocrine diseases

Aliases & Classifications for Hereditary Paraganglioma-Pheochromocytoma Syndromes

MalaCards integrated aliases for Hereditary Paraganglioma-Pheochromocytoma Syndromes:

Name: Hereditary Paraganglioma-Pheochromocytoma Syndromes 23 24 28
Hereditary Pheochromocytoma-Paraganglioma 49 24 55
Hereditary Paraganglioma-Pheochromocytoma 49 24
Familial Pheochromocytoma-Paraganglioma 49 55
Paragangliomas 4 24 69
Paragangliomas 2 24 69
Paragangliomas 3 24 69
Familial Paraganglioma-Pheochromocytoma Syndromes 24
Sdhx-Related Paraganglioma-Pheochromocytoma 49
Familial Nonchromaffin Paragangliomas 23
Familial Paraganglioma Syndrome 24
Familial Glomus Tumors 23
Paragangliomas 1 24
Paraganglioma 69
Fpgl/pheo 24
Fpgl 24

Characteristics:

Orphanet epidemiological data:

55
hereditary pheochromocytoma-paraganglioma
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: adult;

GeneReviews:

23
Penetrance Age-related penetrance. pathogenic variants in the genes encoding the subunits of sdh appear to have a high but age-related penetrance (table 3). data, however, are limited [neumann et al 2004, benn et al 2006, jafri et al 2013]...

Classifications:



External Ids:

Orphanet 55 ORPHA29072
ICD10 via Orphanet 33 C74.1 C75.5 D35.0 more

Summaries for Hereditary Paraganglioma-Pheochromocytoma Syndromes

Genetics Home Reference : 24 Hereditary paraganglioma-pheochromocytoma is an inherited condition characterized by the growth of noncancerous (benign) tumors in structures called paraganglia. Paraganglia are groups of cells that are found near nerve cell bunches called ganglia. A tumor involving the paraganglia is known as a paraganglioma. A type of paraganglioma known as a pheochromocytoma develops in the adrenal glands, which are located on top of each kidney and produce hormones in response to stress. Other types of paraganglioma are usually found in the head, neck, or trunk. People with hereditary paraganglioma-pheochromocytoma develop one or more paragangliomas, which may include pheochromocytomas.

MalaCards based summary : Hereditary Paraganglioma-Pheochromocytoma Syndromes, also known as hereditary pheochromocytoma-paraganglioma, is related to paragangliomas 1 and pheochromocytoma, and has symptoms including paraganglioma, extraadrenal pheochromocytoma and adrenal pheochromocytoma. An important gene associated with Hereditary Paraganglioma-Pheochromocytoma Syndromes is MAX (MYC Associated Factor X), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Pathways in cancer. Affiliated tissues include adrenal gland, kidney and testes, and related phenotypes are Decreased viability and Decreased viability

NIH Rare Diseases : 49 This condition doesn't have a summary yet. Please see our page(s) on Neuroendocrine tumor.

GeneReviews: NBK1548

Related Diseases for Hereditary Paraganglioma-Pheochromocytoma Syndromes

Diseases related to Hereditary Paraganglioma-Pheochromocytoma Syndromes via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 paragangliomas 1 32.1 SDHB SDHC SDHD
2 pheochromocytoma 29.1 FH KIF1B MAX RET SDHA SDHB
3 paraganglioma 28.1 FH RET SDHA SDHAF2 SDHB SDHC
4 acromegaly 11.3
5 paragangliomas 4 11.3
6 paragangliomas 2 11.3
7 paragangliomas 3 11.3
8 glomus tumor 10.2 SDHB SDHD
9 multiple endocrine neoplasia, type iia 10.1 RET SDHB SDHD
10 seminal vesicle tumor 10.1 SDHA SDHB
11 paraganglioma and gastric stromal sarcoma 10.1 SDHB SDHC SDHD
12 multiple endocrine neoplasia, type i 10.1 RET SDHB SDHD
13 chondroma 10.1 SDHB SDHC SDHD
14 renal oncocytoma 10.0 MAX SDHB
15 quadriplegia 10.0 SDHA SDHD
16 cowden disease 9.9 RET SDHB SDHC SDHD
17 endocrine gland cancer 9.9 RET SDHB SDHC SDHD
18 extra-adrenal pheochromocytoma 9.9 SDHAF2 SDHB SDHC SDHD
19 hereditary leiomyomatosis and renal cell cancer 9.9 FH SDHB
20 lymphatic system disease 9.8 SDHB SDHC SDHD TMEM127
21 carney triad 9.8 SDHA SDHB SDHC SDHD
22 familial renal papillary carcinoma 9.8 FH RET
23 gastrointestinal stromal tumor 9.8 SDHA SDHB SDHC SDHD
24 fumarate hydratase deficiency 9.8 FH VHL
25 multiple endocrine neoplasia 9.7 RET SDHB SDHC VHL
26 adrenal medulla cancer 9.7 RET SDHAF2 SDHB SDHC SDHD
27 von hippel-lindau syndrome 9.6 RET SDHB SDHC SDHD VHL
28 neural crest tumor 9.6 SDHA SDHAF2 SDHB SDHC SDHD
29 neurofibromatosis, type iv, of riccardi 9.6 RET SDHB SDHC SDHD VHL
30 mitochondrial complex ii deficiency 9.5 SDHA SDHAF2 SDHB SDHC SDHD
31 leiomyomatosis 9.5 FH SDHB
32 kidney cancer 9.5 FH SDHB VHL
33 sporadic pheochromocytoma 9.4 MAX RET SDHB SDHC SDHD VHL
34 renal cell carcinoma, nonpapillary 9.3 FH SDHB SDHC VHL
35 lymph node disease 9.3 SDHA SDHAF2 SDHB SDHC SDHD TMEM127
36 persistent generalized lymphadenopathy 9.1 RET SDHA SDHAF2 SDHB SDHC SDHD
37 phaeochromocytoma 9.0 RET SDHAF2 SDHB SDHC SDHD TMEM127

Graphical network of the top 20 diseases related to Hereditary Paraganglioma-Pheochromocytoma Syndromes:



Diseases related to Hereditary Paraganglioma-Pheochromocytoma Syndromes

Symptoms & Phenotypes for Hereditary Paraganglioma-Pheochromocytoma Syndromes

Human phenotypes related to Hereditary Paraganglioma-Pheochromocytoma Syndromes:

55 (show all 41)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 paraganglioma 55 Very frequent (99-80%)
2 extraadrenal pheochromocytoma 55 Very frequent (99-80%)
3 adrenal pheochromocytoma 55 Very frequent (99-80%)
4 proteinuria 55 Frequent (79-30%)
5 glomerulosclerosis 55 Frequent (79-30%)
6 episodic paroxysmal anxiety 55 Frequent (79-30%)
7 episodic hyperhidrosis 55 Frequent (79-30%)
8 hypertensive retinopathy 55 Frequent (79-30%)
9 cerebral hemorrhage 55 Frequent (79-30%)
10 dysphonia 55 Frequent (79-30%)
11 weight loss 55 Frequent (79-30%)
12 palpitations 55 Frequent (79-30%)
13 nausea 55 Frequent (79-30%)
14 recurrent paroxysmal headache 55 Frequent (79-30%)
15 episodic abdominal pain 55 Frequent (79-30%)
16 hypertension associated with pheochromocytoma 55 Frequent (79-30%)
17 paraganglioma of head and neck 55 Frequent (79-30%)
18 hypercalcemia 55 Frequent (79-30%)
19 elevated urinary norepinephrine 55 Frequent (79-30%)
20 positive regitine blocking test 55 Frequent (79-30%)
21 elevated urinary epinephrine 55 Frequent (79-30%)
22 pulsatile tinnitus 55 Frequent (79-30%)
23 paroxysmal vertigo 55 Frequent (79-30%)
24 sinus tachycardia 55 Frequent (79-30%)
25 elevated urinary dopamine 55 Frequent (79-30%)
26 fatigue 55 Frequent (79-30%)
27 flushing 55 Frequent (79-30%)
28 chest pain 55 Frequent (79-30%)
29 conductive hearing impairment 55 Occasional (29-5%)
30 hematuria 55 Occasional (29-5%)
31 pallor 55 Occasional (29-5%)
32 cranial nerve compression 55 Occasional (29-5%)
33 tremor 55 Occasional (29-5%)
34 vocal cord paralysis 55 Occasional (29-5%)
35 congestive heart failure 55 Occasional (29-5%)
36 elevated calcitonin 55 Occasional (29-5%)
37 renal cell carcinoma 55 Occasional (29-5%)
38 retinal capillary hemangioma 55 Occasional (29-5%)
39 arachnoid hemangiomatosis 55 Occasional (29-5%)
40 panic attack 55 Occasional (29-5%)
41 aniridia 55 Very rare (<4-1%)

UMLS symptoms related to Hereditary Paraganglioma-Pheochromocytoma Syndromes:


aphonia

GenomeRNAi Phenotypes related to Hereditary Paraganglioma-Pheochromocytoma Syndromes according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.47 RET SDHD VHL
2 Decreased viability GR00221-A-2 9.47 MAX RET SDHD VHL
3 Decreased viability GR00221-A-3 9.47 MAX
4 Decreased viability GR00221-A-4 9.47 RET SDHD
5 Decreased viability GR00231-A 9.47 RET
6 Decreased viability GR00301-A 9.47 RET VHL
7 Decreased viability GR00381-A-1 9.47 SDHD

MGI Mouse Phenotypes related to Hereditary Paraganglioma-Pheochromocytoma Syndromes:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 FH KIF1B RET SDHA SDHB SDHC
2 mortality/aging MP:0010768 9.28 FH KIF1B MAX RET SDHA SDHB

Drugs & Therapeutics for Hereditary Paraganglioma-Pheochromocytoma Syndromes

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268

Search NIH Clinical Center for Hereditary Paraganglioma-Pheochromocytoma Syndromes

Genetic Tests for Hereditary Paraganglioma-Pheochromocytoma Syndromes

Genetic tests related to Hereditary Paraganglioma-Pheochromocytoma Syndromes:

# Genetic test Affiliating Genes
1 Hereditary Paraganglioma-Pheochromocytoma Syndromes 28 MAX

Anatomical Context for Hereditary Paraganglioma-Pheochromocytoma Syndromes

MalaCards organs/tissues related to Hereditary Paraganglioma-Pheochromocytoma Syndromes:

38
Adrenal Gland, Kidney, Testes, Heart

Publications for Hereditary Paraganglioma-Pheochromocytoma Syndromes

Articles related to Hereditary Paraganglioma-Pheochromocytoma Syndromes:

# Title Authors Year
1
The utility of SDHB and FH immunohistochemistry in patients evaluated for hereditary paraganglioma-pheochromocytoma syndromes. ( 29079178 )
2018
2
The Hereditary Paraganglioma-Pheochromocytoma Syndrome: No Time to Waste. ( 28837713 )
2017
3
Multimodality Radionuclide Imaging in a Patient With Hereditary Paraganglioma-Pheochromocytoma Syndrome. ( 28902732 )
2017
4
The Hereditary Paraganglioma-Pheochromocytoma Syndrome: No Time to Waste-Reply. ( 28837712 )
2017
5
Hereditary paraganglioma-pheochromocytoma syndromes associated with SDHD and RET mutations. ( 24375508 )
2013
6
Hereditary Paraganglioma-Pheochromocytoma Syndromes ( 20301715 )
1993

Variations for Hereditary Paraganglioma-Pheochromocytoma Syndromes

ClinVar genetic disease variations for Hereditary Paraganglioma-Pheochromocytoma Syndromes:

6 (show top 50) (show all 145)
# Gene Variation Type Significance SNP ID Assembly Location
1 SDHB NM_003000.2(SDHB): c.268C> T (p.Arg90Ter) single nucleotide variant Pathogenic rs74315366 GRCh37 Chromosome 1, 17359573: 17359573
2 SDHB NM_003000.2(SDHB): c.590C> G (p.Pro197Arg) single nucleotide variant Pathogenic/Likely pathogenic rs74315367 GRCh37 Chromosome 1, 17350520: 17350520
3 SDHB NM_003000.2(SDHB): c.725G> A (p.Arg242His) single nucleotide variant Pathogenic rs74315368 GRCh37 Chromosome 1, 17349143: 17349143
4 SDHB NM_003000.2(SDHB): c.716_719delCTCT (p.Ser239Tyrfs) deletion Pathogenic rs587781266 GRCh38 Chromosome 1, 17022654: 17022657
5 SDHB NM_003000.2(SDHB): c.79C> T (p.Arg27Ter) single nucleotide variant Pathogenic rs74315369 GRCh37 Chromosome 1, 17371377: 17371377
6 SDHB NM_003000.2(SDHB): c.(?_-151)_(72+1_73-1)del deletion Pathogenic
7 SDHB NM_003000.2(SDHB): c.395A> C (p.His132Pro) single nucleotide variant Pathogenic rs74315372 GRCh37 Chromosome 1, 17355123: 17355123
8 SDHB NM_003000.2(SDHB): c.418G> T (p.Val140Phe) single nucleotide variant Pathogenic/Likely pathogenic rs267607032 GRCh37 Chromosome 1, 17355100: 17355100
9 SDHB NC_000001.10: g.17375249_17390927del15679 deletion Pathogenic GRCh37 Chromosome 1, 17375249: 17390927
10 SDHB NC_000001.10: g.17376556_17396932del20377 deletion Pathogenic GRCh37 Chromosome 1, 17376556: 17396932
11 SDHD NM_003002.3(SDHD): c.284T> C (p.Leu95Pro) single nucleotide variant Pathogenic rs80338846 GRCh37 Chromosome 11, 111959705: 111959705
12 MAX NM_002382.4(MAX): c.223C> T (p.Arg75Ter) single nucleotide variant Pathogenic,risk factor rs387906650 GRCh37 Chromosome 14, 65544703: 65544703
13 MAX NM_002382.4(MAX): c.97C> T (p.Arg33Ter) single nucleotide variant Pathogenic,risk factor rs387906651 GRCh37 Chromosome 14, 65560500: 65560500
14 SDHB NM_003000.2(SDHB): c.423+1G> A single nucleotide variant Pathogenic rs398122805 GRCh37 Chromosome 1, 17355094: 17355094
15 SDHC NM_003001.3(SDHC): c.43C> T (p.Arg15Ter) single nucleotide variant Pathogenic rs201286421 GRCh37 Chromosome 1, 161293426: 161293426
16 SDHB NM_003000.2(SDHB): c.287-1G> C single nucleotide variant Pathogenic/Likely pathogenic rs397516833 GRCh37 Chromosome 1, 17355232: 17355232
17 SDHB NM_003000.2(SDHB): c.600G> A (p.Trp200Ter) single nucleotide variant Pathogenic/Likely pathogenic rs397516836 GRCh37 Chromosome 1, 17350510: 17350510
18 TMEM127 NM_017849.3(TMEM127): c.265_268delACAG (p.Thr89Cysfs) deletion Likely pathogenic rs121908822 GRCh37 Chromosome 2, 96920712: 96920715
19 SDHB NM_003000.2(SDHB): c.286+2T> A single nucleotide variant Pathogenic/Likely pathogenic rs587781270 GRCh38 Chromosome 1, 17033058: 17033058
20 SDHB NM_003000.2(SDHB): c.575G> A (p.Cys192Tyr) single nucleotide variant Pathogenic/Likely pathogenic rs397516835 GRCh37 Chromosome 1, 17350535: 17350535
21 SDHB NM_003000.2(SDHB): c.689G> A (p.Arg230His) single nucleotide variant Pathogenic rs587782604 GRCh37 Chromosome 1, 17349179: 17349179
22 SDHB NM_003000.2(SDHB): c.136C> T (p.Arg46Ter) single nucleotide variant Pathogenic rs74315370 GRCh38 Chromosome 1, 17044825: 17044825
23 SDHB NM_003000.2(SDHB): c.72+1G> T single nucleotide variant Pathogenic rs587782703 GRCh37 Chromosome 1, 17380442: 17380442
24 SDHB NM_003000.2(SDHB): c.260T> C (p.Leu87Ser) single nucleotide variant Likely pathogenic rs727504457 GRCh37 Chromosome 1, 17359581: 17359581
25 TMEM127 NM_017849.3(TMEM127): c.308delG (p.Gly103Alafs) deletion Likely pathogenic rs727503490 GRCh37 Chromosome 2, 96920672: 96920672
26 SDHD NM_003002.3(SDHD): c.*(?_286)_*(387_?)del deletion Likely pathogenic GRCh37 Chromosome 11, 111965980: 111966081
27 SDHC NM_003001.3(SDHC): c.397C> T (p.Arg133Ter) single nucleotide variant Pathogenic rs764575966 GRCh37 Chromosome 1, 161326622: 161326622
28 SDHB NM_003000.2(SDHB): c.724C> T (p.Arg242Cys) single nucleotide variant Pathogenic rs786203251 GRCh38 Chromosome 1, 17022649: 17022649
29 SDHB NM_003000.2(SDHB): c.689G> T (p.Arg230Leu) single nucleotide variant Pathogenic/Likely pathogenic rs587782604 GRCh37 Chromosome 1, 17349179: 17349179
30 SDHB NM_003000.2(SDHB): c.688C> T (p.Arg230Cys) single nucleotide variant Pathogenic rs138996609 GRCh37 Chromosome 1, 17349180: 17349180
31 SDHB NM_003000.2(SDHB): c.600G> T (p.Trp200Cys) single nucleotide variant Pathogenic rs397516836 GRCh37 Chromosome 1, 17350510: 17350510
32 SDHB NM_003000.2(SDHB): c.574T> C (p.Cys192Arg) single nucleotide variant Pathogenic/Likely pathogenic rs786202732 GRCh38 Chromosome 1, 17024041: 17024041
33 SDHB NM_003000.2(SDHB): c.541-2A> G single nucleotide variant Pathogenic/Likely pathogenic rs786201161 GRCh37 Chromosome 1, 17350571: 17350571
34 SDHB NM_003000.2(SDHB): c.380T> G (p.Ile127Ser) single nucleotide variant Pathogenic/Likely pathogenic rs786201095 GRCh37 Chromosome 1, 17355138: 17355138
35 SDHB NM_003000.2(SDHB): c.286+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs786201063 GRCh37 Chromosome 1, 17359554: 17359554
36 SDHB NM_003000.2(SDHB): c.166_170delCCTCA (p.Pro56Tyrfs) deletion Pathogenic rs786202100 GRCh37 Chromosome 1, 17371286: 17371290
37 SDHB NM_003000.2(SDHB): c.137G> A (p.Arg46Gln) single nucleotide variant Pathogenic/Likely pathogenic rs772551056 GRCh37 Chromosome 1, 17371319: 17371319
38 SDHB NM_003000.2(SDHB): c.88delC (p.Gln30Argfs) deletion Pathogenic rs747198089 GRCh37 Chromosome 1, 17371368: 17371368
39 SDHB NM_003000.2(SDHB): c.26T> A (p.Leu9Ter) single nucleotide variant Pathogenic rs786203800 GRCh37 Chromosome 1, 17380489: 17380489
40 SDHD NM_003002.3(SDHD): c.298_301delACTC (p.Thr100Phefs) deletion Pathogenic/Likely pathogenic rs786203067 GRCh37 Chromosome 11, 111959719: 111959722
41 SDHB NM_003000.2(SDHB): c.343C> T (p.Arg115Ter) single nucleotide variant Pathogenic rs751000085 GRCh37 Chromosome 1, 17355175: 17355175
42 SDHB NM_003000.2(SDHB): c.526G> T (p.Glu176Ter) single nucleotide variant Pathogenic rs794728946 GRCh38 Chromosome 1, 17027763: 17027763
43 SDHAF2 NM_017841.2(SDHAF2): c.232G> A (p.Gly78Arg) single nucleotide variant Pathogenic rs113560320 GRCh37 Chromosome 11, 61205292: 61205292
44 SDHD NM_003002.3(SDHD): c.106C> T (p.Gln36Ter) single nucleotide variant Pathogenic rs104894303 GRCh37 Chromosome 11, 111958634: 111958634
45 SDHD NM_003002.3(SDHD): c.112C> T (p.Arg38Ter) single nucleotide variant Pathogenic rs80338843 GRCh37 Chromosome 11, 111958640: 111958640
46 SDHD NM_003002.3(SDHD): c.52+2T> G single nucleotide variant Pathogenic rs587776644 GRCh38 Chromosome 11, 112086961: 112086961
47 SDHD NM_003002.3(SDHD): c.337_338insT (p.Asp113Valfs) insertion Pathogenic rs587776645 GRCh37 Chromosome 11, 111965551: 111965552
48 SDHD NM_003002.3(SDHD): c.242C> T (p.Pro81Leu) single nucleotide variant Pathogenic rs80338844 GRCh37 Chromosome 11, 111959663: 111959663
49 SDHD NM_003002.3(SDHD): c.274G> T (p.Asp92Tyr) single nucleotide variant Pathogenic rs80338845 GRCh37 Chromosome 11, 111959695: 111959695
50 SDHD NM_003002.3(SDHD): c.305A> T (p.His102Leu) single nucleotide variant Pathogenic/Likely pathogenic rs104894302 GRCh37 Chromosome 11, 111959726: 111959726

Expression for Hereditary Paraganglioma-Pheochromocytoma Syndromes

Search GEO for disease gene expression data for Hereditary Paraganglioma-Pheochromocytoma Syndromes.

Pathways for Hereditary Paraganglioma-Pheochromocytoma Syndromes

Pathways related to Hereditary Paraganglioma-Pheochromocytoma Syndromes according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 FH MDH2 SDHA SDHB SDHC SDHD
2 12.43 FH MAX RET VHL
3 12.11 FH MDH2 SDHA SDHAF2
4
Show member pathways
11.96 FH MDH2 SDHA SDHB SDHC SDHD
5
Show member pathways
11.55 FH MDH2 SDHA SDHB SDHC SDHD
6 11.39 FH MDH2 SDHA
7
Show member pathways
11.11 FH MDH2 SDHA SDHB SDHC SDHD
8
Show member pathways
11.06 FH MDH2

GO Terms for Hereditary Paraganglioma-Pheochromocytoma Syndromes

Cellular components related to Hereditary Paraganglioma-Pheochromocytoma Syndromes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.65 MDH2 SDHA SDHB SDHC SDHD
2 mitochondrion GO:0005739 9.61 FH KIF1B MDH2 SDHA SDHAF2 SDHB
3 respiratory chain complex II GO:0045273 9.16 SDHB SDHC
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHA SDHB SDHC SDHD

Biological processes related to Hereditary Paraganglioma-Pheochromocytoma Syndromes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.8 MDH2 SDHA SDHB SDHC SDHD
2 electron transport chain GO:0022900 9.54 SDHA SDHB SDHC
3 respiratory electron transport chain GO:0022904 9.43 SDHA SDHB
4 aerobic respiration GO:0009060 9.33 MDH2 SDHB SDHC
5 succinate metabolic process GO:0006105 9.32 SDHA SDHB
6 malate metabolic process GO:0006108 9.26 FH MDH2
7 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.26 SDHA SDHAF2 SDHC SDHD
8 tricarboxylic acid cycle GO:0006099 9.17 FH MDH2 SDHA SDHAF2 SDHB SDHC

Molecular functions related to Hereditary Paraganglioma-Pheochromocytoma Syndromes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.46 SDHA SDHB SDHC SDHD
2 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.32 SDHA SDHC
3 ubiquinone binding GO:0048039 9.26 SDHB SDHD
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.13 SDHA SDHB SDHD
5 succinate dehydrogenase activity GO:0000104 8.8 SDHA SDHC SDHD

Sources for Hereditary Paraganglioma-Pheochromocytoma Syndromes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
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41 MeSH
42 MESH via Orphanet
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45 NCI
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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