MCID: HRM002
MIFTS: 49

Hermaphroditism malady

Reproductive diseases, Endocrine diseases categories
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Summaries for Hermaphroditism

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Wikipedia:65 In biology, a hermaphrodite is an organism that has reproductive organs normally associated with both... more...

MalaCards based summary: Hermaphroditism is related to gonadoblastoma and 46xx sex reversal 1. An important gene associated with Hermaphroditism is SRY (sex determining region Y), and among its related pathways are Regulation of Androgen receptor activity and Steroid hormone biosynthesis. The compounds 7a,12a-Dihydroxy-5a-cholestan-3-one and es 936 have been mentioned in the context of this disorder. Affiliated tissues include testes, uterus and kidney, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Aliases & Classifications for Hermaphroditism

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Related Diseases for Hermaphroditism

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Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1gonadoblastoma30.9ZFY, SRY
246xx sex reversal 130.8SRD5A1, SRY
3mixed gonadal dysgenesis30.7SRY, SRD5A1
4dysgerminoma30.6CGA, SRY
5campomelic dysplasia30.6SRY
6androgen insensitivity syndrome30.1SHBG, AR
7amenorrhea30.0SRY, AMH, SHBG
8pseudohermaphroditism30.0AMH, SRY, SRD5A2, AR
9alopecia29.8AR, SHBG
10male infertility29.6AR, SHBG
11hypospadias29.6AR, CGA, SRD5A2, SRD5A1, SRY
12klinefelter's syndrome29.5SHBG, SRD5A1, CGA, AR
13androgenetic alopecia29.3AR, SRD5A2, SRD5A1, SHBG
14infertility29.2AR, CGA, SRY, AMH, SHBG
15cryptorchidism28.8SRD5A1, SRY, AMH, SHBG, CGA, AR
16gynecomastia28.8SHBG, AR, CGA, SRD5A2, SRD5A1, SRY
17testicular disease10.5SRY
18turner syndrome10.4ZFY
19gonadal dysgenesis10.4
2046,xy disorder of sex development and 46,xy complete gonadal dysgenesis10.3SRY, WNT4
21luteoma10.3SRY, CGA
22prostatic hypertrophy10.3AR
23congenital adrenal hyperplasia10.2SRY, SRD5A1
24seminoma10.2
25abrikosov's tumor10.2CGA, AMH
26varicocele10.2CGA, SHBG
27ovarian disease10.1CGA, SHBG
28freemartinism10.1
29penile disease10.1
30vaginitis10.1
31palmoplantar hyperkeratosis and true hermaphroditism10.1
32impotence10.1SHBG, SRD5A1
33short stature10.1SRY, SHBG
34leydig cell tumor10.1CGA, SRD5A1
35hypopituitarism10.1SHBG, CGA
36hypothyroidism10.0SHBG, CGA
37prostate disease10.0SRD5A1, AR
38germ cell cancer10.0CGA, AR
39testicular cancer10.0SHBG, CGA
40precocious puberty10.0SHBG, AMH, CGA
41hepatitis9.9
42hypertension9.9
43myelodysplastic syndromes9.9
44non-gestational ovarian choriocarcinoma9.9
45gestational ovarian choriocarcinoma9.9
46microphthalmia9.9
47mutism9.9
48leech infestation9.9
49sertoli cell tumor9.9
50adrenal carcinoma9.9

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Symptoms for Hermaphroditism

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Drugs & Therapeutics for Hermaphroditism

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Drug clinical trials:

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Genetic Tests for Hermaphroditism

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Anatomical Context for Hermaphroditism

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MalaCards organs/tissues related to Hermaphroditism:

32
Testes, Uterus, Kidney, Testis, Pituitary, Ovary, Cervix

Animal Models for Hermaphroditism or affiliated genes

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MGI Mouse Phenotypes related to Hermaphroditism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.1AMH, SRY, SRD5A1, SRD5A2, WNT4, CGA
2MP:00053796.8AR, RSPO1, AMH, SRY, SRD5A1, SRD5A2

Publications for Hermaphroditism

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Articles related to Hermaphroditism:

(show top 50)    (show all 432)
idTitleAuthorsYear
1
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. (24742721)
2014
2
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. (23727055)
2013
3
Evolutionary transitions among dioecy, androdioecy and hermaphroditism in limnadiid clam shrimp (Branchiopoda: Spinicaudata). (19702888)
2009
4
Surgical treatment of hermaphroditism: experience with 25 cases. (19806042)
2009
5
Sry-negative XX true hermaphroditism in a roe deer. (18524504)
2009
6
Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation. (18085567)
2008
7
First colored illustration and detailed description of hermaphroditism by a Turkish surgeon, Serefeddin SabuncuoA9lu, in the 15th century. (18046159)
2007
8
Hermaphroditism: What's not to like? (17184795)
2007
9
True hermaphroditism with characteristics of Klinefelter's syndrome: a rare presentation. (16042329)
2005
10
Screening for mutations in the WNT-4 gene in patients with 46,XX true hermaphroditism. (15589122)
2004
11
An unusal case of hermaphroditism--a 46,XX/69,XXY chimera. (15270409)
2004
12
Bipolar hermaphroditism of somatic cell as the basis of its being and becoming: celldom appreciated. (12432206)
2002
13
Management of the African child with true hermaphroditism. (11172444)
2001
14
SRY gene transferred to the long arm of the X chromosome in a Y- positive XX true hermaphrodite. (10602113)
2000
15
An unusual case of delusional misidentification: 'delusional hermaphroditism'. (10364732)
1999
16
Vaginal stone in a male patient with true hermaphroditism. (9488939)
1997
17
True hermaphroditism in a wild sheep: A clinical report. (16726991)
1991
18
Sexuality and hermaphroditism in fishes. I. Synchronous functional hermaphroditism in the serranid fish Serranus scriba L. (2341087)
1990
19
True hermaphroditism: a new case with complex mosaicism. (2222927)
1990
20
Gender dysphoria in a child with true hermaphroditism. (3676994)
1987
21
Is true hermaphroditism a primary germ cell disorder? (3601818)
1987
22
Nephroblastoma in an ovotestis of a true hermaphrodite: a case report. (3033335)
1987
23
Plasma androgens during the luteal phase in a case of true hermaphroditism with bilateral ovotestis. (3159938)
1985
24
Whistling maids and crowing hens--hermaphroditism in folklore and biology. (7290904)
1981
25
Hermaphroditism. (7398198)
1980
26
Clinical, cytogenetical, histological, immunological and hormonal studies in a case of true hermaphroditism. (7428182)
1980
27
True hermaphroditism: a clinical description and a proposed function for the long arm of the Y chromosome. (671194)
1978
28
True hermaphroditism: etiology and phenotypic considerations. (365271)
1978
29
Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog. (675252)
1978
30
Report of a case of true hermaphroditism with karyotype 45,X/46,XX/46,X,mar/47,XX,mar. (563432)
1977
31
Gonadoblastoma in a true hermaphrodite with a 46,XX karyotype. (1250564)
1976
32
A case of true hermaphroditism presenting as an undescended testicle. (4154009)
1974
33
True hermaphroditism with XX-XY mosaicism: report of a case. (4737577)
1973
34
High incidence of true hermaphroditism in the early human embryos. (5163617)
1971
35
A possible correlation between chromosomal pattern and gonadal morphology in cases of mixed gonadal dysgenesis, XO-XX and XO-XY mosaicism, true hermaphrodites and XX males. (5649946)
1968
36
Staff conference: University of Tennessee Hospital: hermaphroditism. (5934680)
1966
37
X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome. (4161595)
1966
38
"Mixed" gonadal dysgenesis: a variety of hermaphroditism. (13989874)
1963
39
True hermaphroditism: including a case with chromosome analysis. (14024009)
1962
40
Problems and management of hermaphroditism. (13894000)
1962
41
A case of true hermaphroditism. (13753582)
1960
42
Sex differences in human nuclei with particular reference to the Klinefelter syndrome, gonadal agenesis and other types of hermaphroditism. (13381386)
1956
43
Roentgenological differential diagnosis of simple hypospadia from hypospadia in hermaphroditism]. (13083763)
1953
44
True hermaphroditism. (14888497)
1952
45
A case of hermaphroditism. (14821342)
1951
46
Hermaphroditism and its treatment. (15423773)
1950
47
True hermaphroditism. (20279555)
1946
48
TRUE HERMAPHRODITISM: REPORT OF A CASE WITH NECROPSY. (17856731)
1936
49
Case of Supposed Hermaphroditism. (19975258)
1911
50
Case of Hermaphroditism in a Common Frog (Rana temporaria). (17231850)
1890

Variations for Hermaphroditism

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Expression for genes affiliated with Hermaphroditism

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Expression patterns in normal tissues for genes affiliated with Hermaphroditism

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Pathways for genes affiliated with Hermaphroditism

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Pathways related to Hermaphroditism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SRY, AR
2
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
9.5SRD5A1, SRD5A2
3
Show member pathways
estradiol biosynthesis II37
androgen biosynthesis37
estradiol biosynthesis I37
progesterone biosynthesis37
9.5SRD5A1, SRD5A2
49.5SRD5A2, SRD5A1
59.4CGA, AR
69.3SHBG, AR
7
Show member pathways
9.1CGA, SRD5A2, SRD5A1
8
Show member pathways
9.0SHBG, SRY, AR
9
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
8.6AR, WNT4, SRD5A2, SRD5A1

Compounds for genes affiliated with Hermaphroditism

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Compounds related to Hermaphroditism according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
17a,12a-Dihydroxy-5a-cholestan-3-one249.9SRD5A1, SRD5A2
2es 936619.8SRD5A2, SRD5A1
37a,12a-Dihydroxy-cholestene-3-one249.8SRD5A1, SRD5A2
4boldenone44 1110.7SRD5A1, AR
5formestane449.6SHBG, SRD5A1
6pygeum449.6AR, SRD5A1
7chlormadinone acetate449.5SHBG, AR
8enterolactone449.5SHBG, SRD5A1
9fluoxymesterone44 1110.4AR, SHBG
10ment449.4SRD5A1, SHBG
11epitestosterone449.4SHBG, CGA, SRD5A1
12goserelin44 28 1111.4CGA, SHBG, SRD5A1
13dutasteride44 1110.3SRD5A1, AR, SRD5A2
14oxandrolone44 1110.3SHBG, AR
1517-hydroxyprogesterone44 2410.3CGA, SHBG, SRD5A1
16leuprolide44 61 28 1112.3AR, CGA, SRD5A1
17phenytoin44 50 28 1112.2CGA, SHBG, SRD5A1
18letrozole44 50 61 1112.2AR, CGA, SHBG
19stanozolol449.2AR, SHBG
20norgestimate44 1110.2SRD5A1, AR, SHBG
21androstenediol449.2AR, SRD5A1, SHBG
225alpha-androstane-3alpha,17beta-diol449.2AR, SRD5A1, SHBG
23deoxyribonucleic acid449.2SRD5A2, ZFY, SRY
24diethylstilbestrol44 28 1111.2AR, SHBG, CGA
25exemestane44 50 61 1112.2SRD5A1, SHBG, AR
26cyproteroneacetate449.2SRD5A1, SHBG, AR
27levonorgestrel44 61 28 1112.2SRD5A1, AR, SHBG
28spironolactone44 61 28 50 1113.2SHBG, SRD5A1, AR
29ketoconazole44 28 24 1112.1SHBG, SRD5A1, AR
30progestins449.1SRD5A1, SHBG, AR
31r1881449.0AR, SHBG
32dhea449.0SHBG, SRD5A1, AR
333beta-hydroxysteroid448.9AR, CGA, SRD5A2, SRD5A1
34mifepristone44 28 61 1111.9SHBG, AR, AMH, CGA
3517beta-hydroxysteroid448.9AR, SRD5A2, CGA, SRD5A1
36finasteride44 61 24 1111.8AR, SHBG, SRD5A2, SRD5A1
37hydroxyflutamide44 289.8AR, CGA, SRD5A1, SHBG
38flutamide44 61 1110.8CGA, SRD5A1, AR, SHBG
39dehydroepiandrosterone sulfate448.8SHBG, AR, CGA, SRD5A1
40progestin448.8AR, CGA, SRD5A1, SHBG
41tamoxifen44 50 28 1111.7AR, SHBG, CGA, AMH
42gnrh448.7SRD5A1, CGA, AR, SHBG
43androstenedione44 249.4SHBG, SRD5A1, SRD5A2, CGA, AR
44vitamin d448.3AR, CGA, SRD5A1, SHBG, SRD5A2
45dihydrotestosterone44 28 24 1111.1SHBG, SRD5A1, SRD5A2, CGA, AR, SRY
46steroid448.0SHBG, AR, SRY, SRD5A1, SRD5A2, CGA
47estrogen447.9CGA, SRD5A2, SRD5A1, AMH, SHBG, AR
48estradiol44 24 119.7SHBG, AMH, SRY, SRD5A1, SRD5A2, AR
49progesterone44 28 61 24 1111.7AMH, SRD5A1, SHBG, SRD5A2, WNT4, CGA
50testosterone44 61 24 1110.4WNT4, SHBG, AMH, SRY, SRD5A1, SRD5A2

GO Terms for genes affiliated with Hermaphroditism

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Biological processes related to Hermaphroditism according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of canonical Wnt signaling pathwayGO:0902639.8RSPO1, WNT4
2canonical Wnt signaling pathwayGO:0600709.7WNT4, RSPO1
3sex determinationGO:0075309.7SRD5A1, AMH
4steroid metabolic processGO:0082029.6SRD5A2, SRD5A1
5male gonad developmentGO:0085849.4WNT4, SRD5A2
6androgen biosynthetic processGO:0067029.4SRD5A1, SRD5A2, WNT4
7positive regulation of transcription, DNA-templatedGO:0458939.2AR, WNT4, SRY
8cell differentiationGO:0301549.0AMH, SRY, SRD5A1, SRD5A2
9sex differentiationGO:0075488.9AR, SRD5A1, SRY, AMH
10cell-cell signalingGO:0072678.8AR, CGA, SRD5A2, AMH

Molecular functions related to Hermaphroditism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:0038659.5SRD5A2, SRD5A1
2cholestenone 5-alpha-reductase activityGO:0477519.4SRD5A2, SRD5A1
3receptor bindingGO:0051029.2AR, AMH, RSPO1
4androgen bindingGO:0054979.0AR, SHBG

Products for genes affiliated with Hermaphroditism

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Sources for Hermaphroditism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet