MCID: HRM002
MIFTS: 40

Hermaphroditism malady

Reproductive diseases category

Aliases & Classifications for Hermaphroditism

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Summaries for Hermaphroditism

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MalaCards based summary: Hermaphroditism is related to gonadoblastoma and 46,xx ovotesticular disorder of sex development. An important gene associated with Hermaphroditism is SRY (sex determining region Y), and among its related pathways are Regulation of Androgen receptor activity and Steroid hormone biosynthesis. The compounds 7a,12a-Dihydroxy-5a-cholestan-3-one and es 936 have been mentioned in the context of this disorder. Affiliated tissues include testes, uterus and testis, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Related Diseases for Hermaphroditism

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Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1gonadoblastoma30.9ZFY, SRY
246,xx ovotesticular disorder of sex development30.8SRY, SRD5A1
3mixed gonadal dysgenesis30.7SRD5A1, SRY
4dysgerminoma30.6CGA, SRY
5campomelic dysplasia30.6SRY
6amenorrhea30.0SRY, SHBG, AMH
7pseudohermaphroditism30.0SRD5A2, SRY, AMH, AR
8alopecia29.8SHBG, AR
9hypospadias29.6AR, CGA, SRY, SRD5A2, SRD5A1
10klinefelter's syndrome29.5SRD5A1, CGA, AR, SHBG
11male infertility29.5AR, SHBG
12androgen insensitivity29.2SRD5A2, SRD5A1, SRY, SHBG, AR, CGA
13infertility29.1SHBG, AMH, SRY, CGA, AR
14cryptorchidism28.8SHBG, SRY, SRD5A1, CGA, AR, AMH
15testicular disease10.5SRY
16turner syndrome10.4ZFY
17gonadal dysgenesis10.4
1846,xy disorder of sex development and 46,xy complete gonadal dysgenesis10.3SRY, WNT4
19luteoma10.3SRY, CGA
20prostatic hypertrophy10.2AR
21palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal10.2
22seminoma10.2
2346,xx testicular disorder of sex development10.2
24congenital adrenal hyperplasia10.2SRD5A1, SRY
25abrikosov's tumor10.2AMH, CGA
26varicocele10.1SHBG, CGA
27acne10.1SRD5A1, SHBG
28ovarian disease10.1SHBG, CGA
2946xx sex reversal 110.1
30freemartinism10.1
31vaginitis10.1
32impotence10.1SRD5A1, SHBG
33hypopituitarism10.0SHBG, CGA
34leydig cell tumor10.0SRD5A1, CGA
35prostate disease10.0SRD5A1, AR
36hypothyroidism10.0SHBG, CGA
37germ cell cancer10.0CGA, AR
38complete androgen insensitivity syndrome10.0SHBG, AR
39precocious puberty10.0AMH, CGA, SHBG
40myelodysplastic syndrome9.9
41denys-drash syndrome9.9
42meckel syndrome 19.9
43microphthalmia9.9
44non-gestational ovarian choriocarcinoma9.9
45gestational ovarian choriocarcinoma9.9
46mutism9.9
47leech infestation9.9
48sertoli cell tumor9.9
49adrenal carcinoma9.9
50choriocarcinoma9.9

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Symptoms for Hermaphroditism

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Drugs & Therapeutics for Hermaphroditism

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Drug clinical trials:

Search ClinicalTrials for Hermaphroditism

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

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Anatomical Context for Hermaphroditism

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MalaCards organs/tissues related to Hermaphroditism:

31
Testes, Uterus, Testis, Kidney, Pituitary, Ovary, Cervix

Animal Models for Hermaphroditism or affiliated genes

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MGI Mouse Phenotypes related to Hermaphroditism:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.1AMH, SRY, SRD5A1, SRD5A2, WNT4, CGA
2MP:00053796.8AR, RSPO1, AMH, SRY, SRD5A1, SRD5A2

Publications for Hermaphroditism

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Articles related to Hermaphroditism:

(show top 50)    (show all 431)
idTitleAuthorsYear
1
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. (24742721)
2014
2
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. (23727055)
2013
3
Evolutionary transitions among dioecy, androdioecy and hermaphroditism in limnadiid clam shrimp (Branchiopoda: Spinicaudata). (19702888)
2009
4
Surgical treatment of hermaphroditism: experience with 25 cases. (19806042)
2009
5
Sry-negative XX true hermaphroditism in a roe deer. (18524504)
2009
6
Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation. (18085567)
2008
7
First colored illustration and detailed description of hermaphroditism by a Turkish surgeon, Serefeddin SabuncuoA9lu, in the 15th century. (18046159)
2007
8
Hermaphroditism: What's not to like? (17184795)
2007
9
True hermaphroditism with characteristics of Klinefelter's syndrome: a rare presentation. (16042329)
2005
10
Screening for mutations in the WNT-4 gene in patients with 46,XX true hermaphroditism. (15589122)
2004
11
An unusal case of hermaphroditism--a 46,XX/69,XXY chimera. (15270409)
2004
12
Bipolar hermaphroditism of somatic cell as the basis of its being and becoming: celldom appreciated. (12432206)
2002
13
Management of the African child with true hermaphroditism. (11172444)
2001
14
SRY gene transferred to the long arm of the X chromosome in a Y- positive XX true hermaphrodite. (10602113)
2000
15
An unusual case of delusional misidentification: 'delusional hermaphroditism'. (10364732)
1999
16
Vaginal stone in a male patient with true hermaphroditism. (9488939)
1997
17
True hermaphroditism in a wild sheep: A clinical report. (16726991)
1991
18
Sexuality and hermaphroditism in fishes. I. Synchronous functional hermaphroditism in the serranid fish Serranus scriba L. (2341087)
1990
19
True hermaphroditism: a new case with complex mosaicism. (2222927)
1990
20
Gender dysphoria in a child with true hermaphroditism. (3676994)
1987
21
Is true hermaphroditism a primary germ cell disorder? (3601818)
1987
22
Nephroblastoma in an ovotestis of a true hermaphrodite: a case report. (3033335)
1987
23
Plasma androgens during the luteal phase in a case of true hermaphroditism with bilateral ovotestis. (3159938)
1985
24
Whistling maids and crowing hens--hermaphroditism in folklore and biology. (7290904)
1981
25
Hermaphroditism. (7398198)
1980
26
Clinical, cytogenetical, histological, immunological and hormonal studies in a case of true hermaphroditism. (7428182)
1980
27
True hermaphroditism: etiology and phenotypic considerations. (365271)
1978
28
Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog. (675252)
1978
29
Report of a case of true hermaphroditism with karyotype 45,X/46,XX/46,X,mar/47,XX,mar. (563432)
1977
30
Gonadoblastoma in a true hermaphrodite with a 46,XX karyotype. (1250564)
1976
31
A case of true hermaphroditism presenting as an undescended testicle. (4154009)
1974
32
True hermaphroditism with XX-XY mosaicism: report of a case. (4737577)
1973
33
High incidence of true hermaphroditism in the early human embryos. (5163617)
1971
34
A possible correlation between chromosomal pattern and gonadal morphology in cases of mixed gonadal dysgenesis, XO-XX and XO-XY mosaicism, true hermaphrodites and XX males. (5649946)
1968
35
Staff conference: University of Tennessee Hospital: hermaphroditism. (5934680)
1966
36
X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome. (4161595)
1966
37
"Mixed" gonadal dysgenesis: a variety of hermaphroditism. (13989874)
1963
38
True hermaphroditism: including a case with chromosome analysis. (14024009)
1962
39
Problems and management of hermaphroditism. (13894000)
1962
40
A case of true hermaphroditism. (13753582)
1960
41
Sex differences in human nuclei with particular reference to the Klinefelter syndrome, gonadal agenesis and other types of hermaphroditism. (13381386)
1956
42
Unilateral hermaphroditism in the mouse. (13249096)
1955
43
Roentgenological differential diagnosis of simple hypospadia from hypospadia in hermaphroditism]. (13083763)
1953
44
True hermaphroditism. (14888497)
1952
45
A case of hermaphroditism. (14821342)
1951
46
Hermaphroditism and its treatment. (15423773)
1950
47
True hermaphroditism. (20279555)
1946
48
TRUE HERMAPHRODITISM: REPORT OF A CASE WITH NECROPSY. (17856731)
1936
49
Case of Supposed Hermaphroditism. (19975258)
1911
50
Case of Hermaphroditism in a Common Frog (Rana temporaria). (17231850)
1890

Variations for Hermaphroditism

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Expression for genes affiliated with Hermaphroditism

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Search GEO for disease gene expression data for Hermaphroditism.

Pathways for genes affiliated with Hermaphroditism

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Pathways related to Hermaphroditism according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SRY, AR
2
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
9.5SRD5A2, SRD5A1
3
Show member pathways
estradiol biosynthesis II36
androgen biosynthesis36
estradiol biosynthesis I36
progesterone biosynthesis36
9.5SRD5A2, SRD5A1
49.5SRD5A2, SRD5A1
59.4AR, CGA
69.3AR, SHBG
7
Show member pathways
9.1SRD5A1, SRD5A2, CGA
8
Show member pathways
9.0SHBG, SRY, AR
9
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
8.6AR, WNT4, SRD5A2, SRD5A1

Compounds for genes affiliated with Hermaphroditism

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Compounds related to Hermaphroditism according to GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
17a,12a-Dihydroxy-5a-cholestan-3-one249.9SRD5A1, SRD5A2
2es 936609.8SRD5A2, SRD5A1
37a,12a-Dihydroxy-cholestene-3-one249.8SRD5A1, SRD5A2
4boldenone44 1110.7SRD5A1, AR
5formestane449.6SHBG, SRD5A1
6pygeum449.6AR, SRD5A1
7chlormadinone acetate449.5SHBG, AR
8enterolactone449.5SHBG, SRD5A1
9fluoxymesterone44 1110.4AR, SHBG
10ment449.4SRD5A1, SHBG
11epitestosterone449.4SHBG, CGA, SRD5A1
12goserelin44 28 1111.4CGA, SHBG, SRD5A1
13dutasteride44 1110.3SRD5A1, AR, SRD5A2
14oxandrolone44 1110.3SHBG, AR
1517-hydroxyprogesterone44 2410.3CGA, SHBG, SRD5A1
16leuprolide44 60 28 1112.3AR, CGA, SRD5A1
17phenytoin44 50 28 1112.2CGA, SHBG, SRD5A1
18letrozole44 50 60 1112.2AR, CGA, SHBG
19stanozolol449.2AR, SHBG
20norgestimate44 1110.2SRD5A1, AR, SHBG
21androstenediol449.2AR, SRD5A1, SHBG
225alpha-androstane-3alpha,17beta-diol449.2AR, SRD5A1, SHBG
23deoxyribonucleic acid449.2SRD5A2, ZFY, SRY
24diethylstilbestrol44 28 1111.2AR, SHBG, CGA
25exemestane44 50 60 1112.2SRD5A1, SHBG, AR
26cyproteroneacetate449.2SRD5A1, SHBG, AR
27levonorgestrel44 60 28 1112.2SRD5A1, AR, SHBG
28spironolactone44 60 28 50 1113.2SHBG, SRD5A1, AR
29ketoconazole44 28 24 1112.1SHBG, SRD5A1, AR
30progestins449.1SRD5A1, SHBG, AR
31r1881449.0AR, SHBG
32dhea449.0SHBG, SRD5A1, AR
333beta-hydroxysteroid448.9AR, CGA, SRD5A2, SRD5A1
34mifepristone44 28 60 1111.9SHBG, AR, AMH, CGA
3517beta-hydroxysteroid448.9AR, SRD5A2, CGA, SRD5A1
36finasteride44 60 24 1111.8AR, SHBG, SRD5A2, SRD5A1
37hydroxyflutamide44 289.8AR, CGA, SRD5A1, SHBG
38flutamide44 60 1110.8CGA, SRD5A1, AR, SHBG
39dehydroepiandrosterone sulfate448.8SHBG, AR, CGA, SRD5A1
40progestin448.8AR, CGA, SRD5A1, SHBG
41tamoxifen44 50 28 1111.7AR, SHBG, CGA, AMH
42gnrh448.7SRD5A1, CGA, AR, SHBG
43androstenedione44 249.4SHBG, SRD5A1, SRD5A2, CGA, AR
44vitamin d448.3AR, CGA, SRD5A1, SHBG, SRD5A2
45dihydrotestosterone44 28 24 1111.1SHBG, SRD5A1, SRD5A2, CGA, AR, SRY
46steroid448.0SHBG, AR, SRY, SRD5A1, SRD5A2, CGA
47estrogen447.9CGA, SRD5A2, SRD5A1, AMH, SHBG, AR
48estradiol44 24 119.7SHBG, AMH, SRY, SRD5A1, SRD5A2, AR
49progesterone44 28 60 24 1111.7AMH, SRD5A1, SHBG, SRD5A2, WNT4, CGA
50testosterone44 60 24 1110.4WNT4, SHBG, AMH, SRY, SRD5A1, SRD5A2

GO Terms for genes affiliated with Hermaphroditism

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Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of canonical Wnt signaling pathwayGO:00902639.8RSPO1, WNT4
2canonical Wnt signaling pathwayGO:00600709.7WNT4, RSPO1
3sex determinationGO:00075309.7SRD5A1, AMH
4steroid metabolic processGO:00082029.6SRD5A2, SRD5A1
5male gonad developmentGO:00085849.4WNT4, SRD5A2
6androgen biosynthetic processGO:00067029.4SRD5A1, SRD5A2, WNT4
7positive regulation of transcription, DNA-templatedGO:00458939.2AR, WNT4, SRY
8cell differentiationGO:00301549.0AMH, SRY, SRD5A1, SRD5A2
9sex differentiationGO:00075488.9AR, SRD5A1, SRY, AMH
10cell-cell signalingGO:00072678.8AR, CGA, SRD5A2, AMH

Molecular functions related to Hermaphroditism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00038659.5SRD5A2, SRD5A1
2cholestenone 5-alpha-reductase activityGO:00477519.4SRD5A2, SRD5A1
3receptor bindingGO:00051029.2AR, AMH, RSPO1
4androgen bindingGO:00054979.0AR, SHBG

Sources for Hermaphroditism

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet