MCID: HRM002
MIFTS: 43

Hermaphroditism malady

Reproductive category

Summaries for Hermaphroditism

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 In biology, a hermaphrodite is an organism that has reproductive organs normally associated with both... more...

MalaCards: Hermaphroditism is related to mixed gonadal dysgenesis and klinefelter's syndrome. An important gene associated with Hermaphroditism is SRY (sex determining region Y), and among its related pathways are Androgen biosynthesis and Metabolism of steroid hormones and vitamin D. The compounds estrogen and epitestosterone have been mentioned in the context of this disorder. Related mouse phenotypes are growth/size and endocrine/exocrine gland.

Aliases & Classifications for Hermaphroditism

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 25ICD10
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Related Diseases for Hermaphroditism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1mixed gonadal dysgenesis35.4SRD5A1, SRY
2klinefelter's syndrome35.2GNRHR, AR, CGA, SHBG, CYP19A1, SRD5A1
3hypospadias35.1AR, CGA, SRY, SRD5A1, SRD5A2
446xx sex reversal 135.1SRY, SRD5A1
5androgen insensitivity syndrome34.9AR, CGA, SHBG, SRY, SRD5A1, SRD5A2
6cryptorchidism34.9SRD5A1, SRY, CYP19A1, SHBG, CGA, AR
7gynecomastia34.9BRCA2, SRD5A2, SRD5A1, SRY, CYP19A1, SHBG
8gonadoblastoma30.4SRY, ZFY
9dysgerminoma30.2BRCA2, CGA, SRY
10campomelic dysplasia29.9SRY, SOX9
11amenorrhea29.9AMH, SHBG, SRY
12alopecia29.9SHBG, AR
13swyer syndrome29.9SOX9, SRY
14sertoli cell tumor29.9AR, CYP19A1
15infertility29.8AMH, GNRHR, AR, CGA, SHBG, CYP19A1
16hyperprolactinemia13.3CGA, SHBG, SRD5A1
17hyperandrogenism13.3AMH, AR, CGA, SHBG, CYP19A1, SRD5A1
18polycystic ovary syndrome13.3AR, CGA, SHBG, CYP19A1, SRD5A1
19androgenic alopecia13.3AR, SHBG, CYP19A1, SRD5A1, SRD5A2
20congenital adrenal hyperplasia13.3SRD5A1, SRY, CYP19A1
21oligospermia13.3AMH, GNRHR, AR, CGA, FSHB, SRD5A1
22azoospermia13.3SRD5A1, SRY, FSHB, ZFY, SHBG, CGA
23anovulation13.3AMH, CGA, SHBG, CYP19A1, SRD5A1
24adenocarcinoma13.3BRCA2, GNRHR, AR, SRD5A1
25adenoma13.3SRD5A1, FSHB, SHBG, CGA, GNRHR
26breast cancer13.3BRCA2, GNRHR, AR, SHBG, CYP19A1, SRD5A1
27impotence13.3SRD5A1, SHBG
28leydig cell tumor13.3CGA, CYP19A1, SRD5A1
29obesity13.3AR, SHBG, SRD5A1
30prostate cancer13.3GNRHR, AR, SRD5A1, SRD5A2
31prostate disease13.3SRD5A1, CYP19A1, AR
32prostatitis13.3SRD5A1
33wilms tumor13.3BRCA2, SOX9, SRY, SRD5A1
34penis agenesis13.3SRD5A2, SRD5A1, CGA, AR
35partial androgen insensitivity syndrome13.3AR, SHBG, CYP19A1, SRD5A1
36palmoplantar hyperkeratosis and true hermaphroditism10.1
37premature ovarian failure10.0AMH
38testicular disease10.0SRY
39thyroiditis10.0CGA
40conduct disorder10.0CGA
41prostatic hypertrophy10.0AR
42hypoactive sexual desire disorder10.0SHBG
43insulin resistance10.0SHBG
44gonadal dysgenesis10.0SOX9, SRY
45ductal carcinoma in situ10.0BRCA2
46frasier syndrome10.0SRY
47hypopituitarism10.0SHBG, CGA
48prolactinoma10.0GNRHR, CGA
49luteoma10.0CGA, SRY
5046,xy disorder of sex development and 46,xy complete gonadal dysgenesis10.0WNT4, SRY

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Clinical Features for Hermaphroditism

Drugs & Therapeutics for Hermaphroditism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Hermaphroditism

Drug clinical trials:

Search ClinicalTrials for Hermaphroditism

Search NIH Clinical Center for Hermaphroditism

Search CenterWatch for Hermaphroditism

Genetic Tests for Hermaphroditism

Anatomical Context for Hermaphroditism

Animal Models for Hermaphroditism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hermaphroditism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.2GNRHR, SOX9, CSNK1D, AR, RBFOX1, CGA
2MP:00053797.1AR, SOX9, GNRHR, AMH, BRCA2, CGA
3MP:00053896.9RSPO1, BRCA2, AMH, GNRHR, SOX9, AR

Publications for Hermaphroditism

Sources:
51PubMed
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Articles related to Hermaphroditism:

(show top 50)    (show all 406)
idTitleAuthorsYear
1
Linking micromorphism, brooding, and hermaphroditism in brachiopods: insights from Caribbean Argyrotheca (Brachiopoda). (23400897)
2013
2
Female pseudo-hermaphroditism with cloacal malformation and related anomalies in a dog. (23543931)
2012
3
True hermaphroditism: first evidence of an ovotestis in a cetacean species. (20708743)
2011
4
Pure ovarian choriocarinoma mimicking ectopic pregnancy in true hermaphroditism. (19363709)
2009
5
True hermaphroditism. (19094457)
2008
6
Hermaphroditism: What's not to like? (17184795)
2007
7
Hermaphroditism in a Sprague-Dawley rat. (17491092)
2007
8
True hermaphroditism in a phenotypic male without ambiguous genitalia: an unusual presentation at puberty. (17505135)
2007
9
True hermaphroditism in six female littermates after administration of synthetic androgens to a pregnant bitch. (16420323)
2006
10
The evolution of gender specialization from dimorphic hermaphroditism: paths from heterodichogamy to gynodioecy and androdioecy. (16739449)
2006
11
Anatomical study on true hermaphroditism in an Indian pig (Sus scrofa domesticus). (15785130)
2005
12
An unusal case of hermaphroditism--a 46,XX/69,XXY chimera. (15270409)
2004
13
Hermaphroditism pathology]. (15785398)
2004
14
Images in clinical medicine. True hermaphroditism. (14736931)
2004
15
Applicability of the SHBG androgen sensitivity test in the differential diagnosis of 46,XY gonadal dysgenesis, true hermaphroditism, and androgen insensitivity syndrome. (15146368)
2004
16
Male pseudo-hermaphroditism in a dog: a clinical case. (11321217)
2000
17
Atypical true hermaphroditism with a mosaic 45,X/46,X,dic(Y) (q11.2) karyotype. (9751378)
1998
18
Vaginal stone in a male patient with true hermaphroditism. (9488939)
1997
19
True hermaphroditism: geographical distribution, clinical findings, chromosomes and gonadal histology. (8313919)
1994
20
Nonrandom inactivation of the Y-bearing X chromosome in a 46,XX individual: evidence for the etiology of 46,XX true hermaphroditism. (8275702)
1994
21
Familial true hermaphroditism: paternal and maternal transmission of true hermaphroditism (46,XX) and XX maleness in the absence of Y-chromosomal sequences. (8262517)
1993
22
Sex-determining region Y (SRY) in a patient with 46,XX true hermaphroditism. (1297452)
1992
23
True hermaphroditism in 45,X/46,XY mosaicism. (1363410)
1992
24
True hermaphroditism in the domestic fowl. (3206796)
1988
25
Preservation of gonadal function in true hermaphroditism. (6699763)
1984
26
H-Y positive 46 XX true hermaphroditism with intrascrotal uterus. (7198944)
1981
27
Familial XX true hermaphroditism and the H-Y antigen. (110671)
1979
28
Presence of H-Y antigen and testis in 46, XX true hermaphroditism, evidence for Y-chromosomal function. (187611)
1976
29
True hermaphroditism with unambiguous male phenotype, pathologic and cytogenetic findings: report of a case. (4859575)
1974
30
True hermaphroditism with XX-XY mosaicism: report of a case. (4737577)
1973
31
True hermaphroditism with oogenesis and spermatogenesis. (4532534)
1973
32
Special female hermaphroditism associated with multiple disorders. (5066658)
1972
33
Evidence of XX-XY sex chromosome mosaicism in a child with true hermaphroditism. (5501705)
1970
34
Hermaphroditism in a rat. (5520717)
1970
35
Hermaphroditism in infancy and childhood. (5913501)
1966
36
The human Y chrosome and the etiology of true hermaphroditism with the report of a case with XX-XY sex chromosome mosaicism. (5889237)
1965
37
True hermaphroditism: including a case with chromosome analysis. (14024009)
1962
38
A case of true lateral hermaphroditism with seminiferous intratubular bodies. (13948576)
1962
39
The diagnosis and treatment of hermaphroditism. (13785822)
1960
40
Recent advances in the diagnosis and treatment of hermaphroditism and intersexuality. (13578121)
1958
41
Sexual incongruities and psychopathology: the evidence of human hermaphroditism. (13276721)
1956
42
Hermaphroditism. (12990969)
1952
43
Hermaphroditism in the lower vertebrates. (20250927)
1947
44
True hermaphroditism. (20279555)
1946
45
A Case of Malformation Assumed to be True Hermaphroditism. (19970086)
1933
46
Pseudo-hermaphroditism. (19988816)
1932
47
So-called True Hermaphroditism, with the Report of a Case. (19978842)
1915
48
Notes of a Case of Pseudo-hermaphroditism. (19975655)
1912
49
Hermaphroditism, in which the Uterus occupied the Sac of an Inguinal Hernia. (19972710)
1908
50
THE CONTENTS OF IRREDUCIBLE INGUINAL HERNIAE IN FEMALE SUBJECTS, AND TRUE HERMAPHRODITISM. (20763628)
1908

Genetic Variations for Hermaphroditism

Expression for genes affiliated with Hermaphroditism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hermaphroditism

Search GEO for disease gene expression data for Hermaphroditism.

Pathways for genes affiliated with Hermaphroditism

Sources:
54Reactome, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 30KEGG, 56SinoBiological, 53R&D Systems
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Compounds for genes affiliated with Hermaphroditism

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 50PharmGKB
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Compounds related to Hermaphroditism according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1estrogen4510.9
2epitestosterone4510.3SHBG, CGA
3formestane4510.2CYP19A1, SHBG
4norgestimate45 1111.2AR, SHBG
5ment4510.2SHBG, CYP19A1
6ganirelix45 2911.1GNRHR, FSHB, CGA
7leuprolide45 60 29 1113.0CGA, GNRHR, AR
8dutasteride45 1111.0AR, SRD5A2, CYP19A1
9hydroxyflutamide45 2911.0AR, CGA, SHBG
10androstanedione45 11 2412.0CYP19A1, SRD5A2
11androstenediol4510.0AR, SHBG, CYP19A1
125alpha-androstane-3alpha,17beta-diol459.9CYP19A1, AR, SHBG
13exemestane50 45 60 1112.9AR, CYP19A1, SHBG
14Drostanolone119.9SHBG, AR, CYP19A1
1517-hydroxyprogesterone45 2410.9CGA, CYP19A1, SHBG
16cyproteroneacetate459.9SHBG, CYP19A1, AR
17levonorgestrel45 60 29 1112.9CYP19A1, AR, SHBG
18nafarelin45 60 29 1112.9GNRHR, CYP19A1, CGA
19buserelin45 29 1111.8CYP19A1, FSHB, CGA, GNRHR
20Methyltestosterone119.8CYP19A1, SHBG, AR
21goserelin45 29 1111.8CGA, SHBG, CYP19A1, GNRHR
22finasteride45 60 11 2412.8AR, SHBG, CYP19A1, SRD5A2
23clomiphene citrate459.7CGA, FSHB, SHBG, CYP19A1
24ketoconazole45 29 11 2412.7SHBG, CYP19A1, AR
253beta-hydroxysteroid459.7AR, CGA, CYP19A1, SRD5A2
2617beta-hydroxysteroid459.7SRD5A2, CYP19A1, CGA, AR
27progestins459.7CYP19A1, AR, SHBG
28flutamide45 60 1111.7CYP19A1, SHBG, CGA, AR
29dehydroepiandrosterone sulfate459.7AR, CGA, SHBG, CYP19A1
30danazol45 11 2411.7GNRHR, AR, SHBG, CYP19A1
31nandrolone45 2410.7CYP19A1, SHBG, AR
32letrozole45 50 60 1112.6SHBG, CGA, AR, CYP19A1
33progestin459.6CYP19A1, AR, SHBG, CGA
34leuprolide acetate459.6SHBG, FSHB, GNRHR, CGA, CYP19A1
35deoxyribonucleic acid459.6GNRHR, ZFY, FSHB, SRY, SRD5A2
36dhea459.5CYP19A1, SHBG, AR
37estrone45 29 11 2412.5SHBG, AR, CYP19A1
38anastrozole45 1110.5CYP19A1, SHBG, CGA
39androstenedione45 2410.5SHBG, CGA, AR, CYP19A1, SRD5A2
40diethylstilbestrol45 29 1111.5CYP19A1, CGA, SHBG, AR
41mifepristone45 60 29 1112.3CYP19A1, SHBG, AMH, CGA, AR
42vitamin d459.3AR, CGA, SHBG, SRD5A2, CYP19A1
43gnrh459.2CYP19A1, GNRHR, AR, CGA, SHBG, FSHB
44dihydrotestosterone45 29 11 2412.1CGA, SHBG, CYP19A1, GNRHR, SRD5A2, SRY
45ribonucleic acid458.9SRD5A2, CGA, GNRHR, SOX9, FSHB
46tamoxifen45 50 29 1111.8AR, SHBG, CGA, BRCA2, AMH, GNRHR
47estradiol45 11 2410.3GNRHR, SRY, BRCA2, AMH, SRD5A2, FSHB
48progesterone45 60 29 11 2412.2SHBG, WNT4, CYP19A1, SRD5A2, FSHB, BRCA2
49steroid458.2BRCA2, CYP19A1, SRD5A2, SRY, FSHB, SHBG
50testosterone45 60 11 2410.7WNT4, SOX9, AR, CGA, SHBG, CYP19A1

GO Terms for genes affiliated with Hermaphroditism

Sources:
16Gene Ontology
See all sources

Biological processes related to Hermaphroditism according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1sex determinationGO:00753010.4AMH
2androgen biosynthetic processGO:00670210.3SRD5A2, WNT4
3sex differentiationGO:00754810.2AMH, AR
4positive regulation of male gonad developmentGO:200002010.2SOX9, SRY
5renal vesicle inductionGO:07203410.2SOX9, WNT4
6tertiary branching involved in mammary gland duct morphogenesisGO:06074810.2AR, WNT4
7steroid metabolic processGO:00820210.2SRD5A2, CYP19A1
8prostate gland developmentGO:03085010.1SOX9, AR
9prostate gland growthGO:06073610.0CYP19A1, AR
10peptide hormone processingGO:01648610.0CGA, FSHB
11androgen metabolic processGO:00820910.0SRD5A2, CYP19A1
12positive regulation of canonical Wnt receptor signaling pathwayGO:0902639.9CSNK1E, CSNK1D, WNT4, RSPO1
13female gonad developmentGO:0085859.7BRCA2, WNT4
14male gonad developmentGO:0085849.5SRD5A2, SRY, WNT4, AR, SOX9
15cell-cell signalingGO:0072679.5SRD5A2, WNT4, CGA, AR, AMH
16spermatogenesisGO:0072839.3FSHB, AR, SOX9, BRCA2
17positive regulation of transcription, DNA-dependentGO:0458939.2BRCA2, SOX9, AR, WNT4, SRY
18positive regulation of cell migrationGO:0303359.2FSHB, RRAS2, CGA
19signal transductionGO:0071659.1SOX9, CSNK1E, CSNK1D, AR, CGA, FSHB

Molecular functions related to Hermaphroditism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00386510.3SRD5A2
2cholestenone 5-alpha-reductase activityGO:04775110.2SRD5A2
3hormone activityGO:0051799.8FSHB, CGA, AMH
4androgen bindingGO:0054979.6SHBG, AR

Products for genes affiliated with Hermaphroditism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hermaphroditism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet