MCID: HRM002
MIFTS: 40

Hermaphroditism malady

Reproductive diseases category

Aliases & Classifications for Hermaphroditism

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Hermaphroditism, Aliases & Descriptions:

Name: Hermaphroditism 9 11 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology9 DOID:3763
NCIt38 C45909
SNOMED-CT55 52572004, 237821001
ICD1025 Q56.0

Summaries for Hermaphroditism

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MalaCards based summary: Hermaphroditism is related to gonadoblastoma and 46,xx ovotesticular disorder of sex development. An important gene associated with Hermaphroditism is SRY (sex determining region Y), and among its related pathways are Regulation of Androgen receptor activity and Steroid hormone biosynthesis. The compounds 7a,12a-Dihydroxy-5a-cholestan-3-one and 7a,12a-Dihydroxy-cholestene-3-one have been mentioned in the context of this disorder. Affiliated tissues include testes, uterus and testis, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Related Diseases for Hermaphroditism

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Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1gonadoblastoma30.9ZFY, SRY
246,xx ovotesticular disorder of sex development30.8SRY, SRD5A1
3mixed gonadal dysgenesis30.7SRD5A1, SRY
4dysgerminoma30.6CGA, SRY
5campomelic dysplasia30.6SRY
6amenorrhea30.0SRY, SHBG, AMH
7pseudohermaphroditism30.0SRD5A2, SRY, AMH, AR
8alopecia29.8SHBG, AR
9hypospadias29.6AR, CGA, SRY, SRD5A2, SRD5A1
10klinefelter's syndrome29.5SRD5A1, CGA, AR, SHBG
11male infertility29.5AR, SHBG
12androgen insensitivity29.2SRD5A2, SRD5A1, SRY, SHBG, AR, CGA
13infertility29.1SHBG, AMH, SRY, CGA, AR
14cryptorchidism28.8SHBG, SRY, SRD5A1, CGA, AR, AMH
15testicular disease10.5SRY
16turner syndrome10.4ZFY
17gonadal dysgenesis10.4
1846,xy disorder of sex development and 46,xy complete gonadal dysgenesis10.3SRY, WNT4
19luteoma10.3SRY, CGA
20prostatic hypertrophy10.2AR
21palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal10.2
22seminoma10.2
2346,xx testicular disorder of sex development10.2
24congenital adrenal hyperplasia10.2SRD5A1, SRY
25abrikosov's tumor10.2AMH, CGA
26varicocele10.1SHBG, CGA
27acne10.1SRD5A1, SHBG
28ovarian disease10.1SHBG, CGA
2946xx sex reversal 110.1
30freemartinism10.1
31vaginitis10.1
32impotence10.1SRD5A1, SHBG
33hypopituitarism10.0SHBG, CGA
34leydig cell tumor10.0SRD5A1, CGA
35prostate disease10.0SRD5A1, AR
36hypothyroidism10.0SHBG, CGA
37germ cell cancer10.0CGA, AR
38complete androgen insensitivity syndrome10.0SHBG, AR
39precocious puberty10.0AMH, CGA, SHBG
40myelodysplastic syndrome9.9
41denys-drash syndrome9.9
42meckel syndrome 19.9
43microphthalmia9.9
44non-gestational ovarian choriocarcinoma9.9
45gestational ovarian choriocarcinoma9.9
46mutism9.9
47leech infestation9.9
48sertoli cell tumor9.9
49adrenal carcinoma9.9
50choriocarcinoma9.9

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Symptoms for Hermaphroditism

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Drugs & Therapeutics for Hermaphroditism

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Drug clinical trials:

Search ClinicalTrials for Hermaphroditism

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

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Anatomical Context for Hermaphroditism

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MalaCards organs/tissues related to Hermaphroditism:

31
Testes, Uterus, Testis, Kidney, Pituitary, Ovary, Cervix

Animal Models for Hermaphroditism or affiliated genes

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MGI Mouse Phenotypes related to Hermaphroditism:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.1AMH, SRY, SRD5A1, SRD5A2, WNT4, CGA
2MP:00053796.8AR, RSPO1, AMH, SRY, SRD5A1, SRD5A2

Publications for Hermaphroditism

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Articles related to Hermaphroditism:

(show top 50)    (show all 431)
idTitleAuthorsYear
1
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. (24742721)
2014
2
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. (23727055)
2013
3
Evolutionary transitions among dioecy, androdioecy and hermaphroditism in limnadiid clam shrimp (Branchiopoda: Spinicaudata). (19702888)
2009
4
Surgical treatment of hermaphroditism: experience with 25 cases. (19806042)
2009
5
Sry-negative XX true hermaphroditism in a roe deer. (18524504)
2009
6
Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation. (18085567)
2008
7
First colored illustration and detailed description of hermaphroditism by a Turkish surgeon, Serefeddin SabuncuoA9lu, in the 15th century. (18046159)
2007
8
Hermaphroditism: What's not to like? (17184795)
2007
9
True hermaphroditism with characteristics of Klinefelter's syndrome: a rare presentation. (16042329)
2005
10
Screening for mutations in the WNT-4 gene in patients with 46,XX true hermaphroditism. (15589122)
2004
11
An unusal case of hermaphroditism--a 46,XX/69,XXY chimera. (15270409)
2004
12
Bipolar hermaphroditism of somatic cell as the basis of its being and becoming: celldom appreciated. (12432206)
2002
13
Management of the African child with true hermaphroditism. (11172444)
2001
14
SRY gene transferred to the long arm of the X chromosome in a Y- positive XX true hermaphrodite. (10602113)
2000
15
An unusual case of delusional misidentification: 'delusional hermaphroditism'. (10364732)
1999
16
Vaginal stone in a male patient with true hermaphroditism. (9488939)
1997
17
True hermaphroditism in a wild sheep: A clinical report. (16726991)
1991
18
Sexuality and hermaphroditism in fishes. I. Synchronous functional hermaphroditism in the serranid fish Serranus scriba L. (2341087)
1990
19
True hermaphroditism: a new case with complex mosaicism. (2222927)
1990
20
Gender dysphoria in a child with true hermaphroditism. (3676994)
1987
21
Is true hermaphroditism a primary germ cell disorder? (3601818)
1987
22
Nephroblastoma in an ovotestis of a true hermaphrodite: a case report. (3033335)
1987
23
Plasma androgens during the luteal phase in a case of true hermaphroditism with bilateral ovotestis. (3159938)
1985
24
Whistling maids and crowing hens--hermaphroditism in folklore and biology. (7290904)
1981
25
Hermaphroditism. (7398198)
1980
26
Clinical, cytogenetical, histological, immunological and hormonal studies in a case of true hermaphroditism. (7428182)
1980
27
True hermaphroditism: etiology and phenotypic considerations. (365271)
1978
28
Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog. (675252)
1978
29
Report of a case of true hermaphroditism with karyotype 45,X/46,XX/46,X,mar/47,XX,mar. (563432)
1977
30
Gonadoblastoma in a true hermaphrodite with a 46,XX karyotype. (1250564)
1976
31
A case of true hermaphroditism presenting as an undescended testicle. (4154009)
1974
32
True hermaphroditism with XX-XY mosaicism: report of a case. (4737577)
1973
33
High incidence of true hermaphroditism in the early human embryos. (5163617)
1971
34
A possible correlation between chromosomal pattern and gonadal morphology in cases of mixed gonadal dysgenesis, XO-XX and XO-XY mosaicism, true hermaphrodites and XX males. (5649946)
1968
35
Staff conference: University of Tennessee Hospital: hermaphroditism. (5934680)
1966
36
X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome. (4161595)
1966
37
"Mixed" gonadal dysgenesis: a variety of hermaphroditism. (13989874)
1963
38
True hermaphroditism: including a case with chromosome analysis. (14024009)
1962
39
Problems and management of hermaphroditism. (13894000)
1962
40
A case of true hermaphroditism. (13753582)
1960
41
Sex differences in human nuclei with particular reference to the Klinefelter syndrome, gonadal agenesis and other types of hermaphroditism. (13381386)
1956
42
Unilateral hermaphroditism in the mouse. (13249096)
1955
43
Roentgenological differential diagnosis of simple hypospadia from hypospadia in hermaphroditism]. (13083763)
1953
44
True hermaphroditism. (14888497)
1952
45
A case of hermaphroditism. (14821342)
1951
46
Hermaphroditism and its treatment. (15423773)
1950
47
True hermaphroditism. (20279555)
1946
48
TRUE HERMAPHRODITISM: REPORT OF A CASE WITH NECROPSY. (17856731)
1936
49
Case of Supposed Hermaphroditism. (19975258)
1911
50
Case of Hermaphroditism in a Common Frog (Rana temporaria). (17231850)
1890

Variations for Hermaphroditism

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Expression for genes affiliated with Hermaphroditism

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Search GEO for disease gene expression data for Hermaphroditism.

Pathways for genes affiliated with Hermaphroditism

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Pathways related to Hermaphroditism according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SRY, AR
2
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
9.5SRD5A2, SRD5A1
3
Show member pathways
estradiol biosynthesis II36
androgen biosynthesis36
estradiol biosynthesis I36
progesterone biosynthesis36
9.5SRD5A2, SRD5A1
49.5SRD5A2, SRD5A1
59.4AR, CGA
69.3AR, SHBG
7
Show member pathways
9.1SRD5A1, SRD5A2, CGA
8
Show member pathways
9.0SHBG, SRY, AR
9
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
8.6AR, WNT4, SRD5A2, SRD5A1

Compounds for genes affiliated with Hermaphroditism

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Compounds related to Hermaphroditism according to GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
17a,12a-Dihydroxy-5a-cholestan-3-one249.9SRD5A1, SRD5A2
27a,12a-Dihydroxy-cholestene-3-one249.8SRD5A2, SRD5A1
3es 936599.8SRD5A1, SRD5A2
4boldenone43 1210.7AR, SRD5A1
5formestane439.6SHBG, SRD5A1
6pygeum439.6SRD5A1, AR
75alpha-dihydroprogesterone439.5SRD5A2, SRD5A1
8enterolactone439.5SHBG, SRD5A1
9fluoxymesterone43 1210.5SHBG, AR
10chlormadinone acetate439.4SHBG, AR
11ment439.4SHBG, SRD5A1
12epitestosterone439.4SRD5A1, SHBG, CGA
13goserelin43 28 1211.4CGA, SRD5A1, SHBG
14dutasteride43 1210.3SRD5A2, AR, SRD5A1
1517-hydroxyprogesterone43 2410.3SHBG, SRD5A1, CGA
16leuprolide43 59 28 1212.3AR, SRD5A1, CGA
17phenytoin43 49 28 1212.2SHBG, SRD5A1, CGA
18letrozole43 49 59 1212.2CGA, AR, SHBG
19stanozolol439.2AR, SHBG
20norgestimate43 1210.2AR, SRD5A1, SHBG
21androstenediol439.2SRD5A1, SHBG, AR
225alpha-androstane-3alpha,17beta-diol439.2AR, SRD5A1, SHBG
23deoxyribonucleic acid439.2ZFY, SRY, SRD5A2
24diethylstilbestrol43 28 1211.2CGA, SHBG, AR
25exemestane43 49 59 1212.2AR, SHBG, SRD5A1
26cyproteroneacetate439.2SRD5A1, AR, SHBG
27levonorgestrel43 59 28 1212.2SHBG, SRD5A1, AR
28spironolactone43 59 28 49 1213.2SRD5A1, SHBG, AR
29ketoconazole43 28 24 1212.1SHBG, SRD5A1, AR
30progestins439.1SRD5A1, AR, SHBG
31r1881439.0SHBG, AR
32dhea439.0AR, SRD5A1, SHBG
333beta-hydroxysteroid438.9SRD5A1, CGA, SRD5A2, AR
3417beta-hydroxysteroid438.9AR, CGA, SRD5A2, SRD5A1
35mifepristone43 28 59 1211.9AR, SHBG, AMH, CGA
36finasteride43 59 24 1211.8SHBG, SRD5A1, SRD5A2, AR
37hydroxyflutamide43 289.8AR, SHBG, SRD5A1, CGA
38flutamide43 59 1210.8AR, CGA, SRD5A1, SHBG
39dehydroepiandrosterone sulfate438.8AR, SRD5A1, CGA, SHBG
40progestin438.8SRD5A1, AR, SHBG, CGA
41tamoxifen43 49 28 1211.7SHBG, CGA, AMH, AR
42gnrh438.7SRD5A1, SHBG, AR, CGA
43androstenedione43 249.4SRD5A1, SRD5A2, AR, SHBG, CGA
44vitamin d438.3SHBG, SRD5A1, SRD5A2, CGA, AR
45dihydrotestosterone43 28 24 1211.1CGA, SRD5A2, SRD5A1, AR, SHBG, SRY
46steroid438.0CGA, AR, SRD5A2, SRY, SHBG, SRD5A1
47estrogen437.9SHBG, AMH, SRD5A2, CGA, SRD5A1, AR
48estradiol43 24 129.7CGA, SRD5A2, SRD5A1, SRY, AMH, SHBG
49progesterone43 28 59 24 1211.7AMH, WNT4, AR, SHBG, SRD5A1, CGA
50testosterone43 59 24 1210.4SRD5A2, SHBG, AMH, SRY, SRD5A1, WNT4

GO Terms for genes affiliated with Hermaphroditism

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Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of canonical Wnt signaling pathwayGO:00902639.8RSPO1, WNT4
2canonical Wnt signaling pathwayGO:00600709.7WNT4, RSPO1
3sex determinationGO:00075309.7SRD5A1, AMH
4steroid metabolic processGO:00082029.6SRD5A2, SRD5A1
5male gonad developmentGO:00085849.4WNT4, SRD5A2
6androgen biosynthetic processGO:00067029.4SRD5A1, SRD5A2, WNT4
7positive regulation of transcription, DNA-templatedGO:00458939.2AR, WNT4, SRY
8cell differentiationGO:00301549.0AMH, SRY, SRD5A1, SRD5A2
9sex differentiationGO:00075488.9AR, SRD5A1, SRY, AMH
10cell-cell signalingGO:00072678.8AR, CGA, SRD5A2, AMH

Molecular functions related to Hermaphroditism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00038659.5SRD5A2, SRD5A1
2cholestenone 5-alpha-reductase activityGO:00477519.4SRD5A2, SRD5A1
3receptor bindingGO:00051029.2AR, AMH, RSPO1
4androgen bindingGO:00054979.0AR, SHBG

Products for genes affiliated with Hermaphroditism

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Sources for Hermaphroditism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet