MCID: HRM002
MIFTS: 36

Hermaphroditism malady

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Hermaphroditism

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Summaries for Hermaphroditism

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MalaCards based summary: Hermaphroditism is related to hypogonadism and pseudohermaphroditism. An important gene associated with Hermaphroditism is SRY (Sex Determining Region Y), and among its related pathways are Regulation of Androgen receptor activity and Deactivation of the beta-catenin transactivating complex. Affiliated tissues include endothelial, breast and lung, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Related Diseases for Hermaphroditism

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Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 347)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadism29.6AR, SHBG, SRY
2pseudohermaphroditism28.5AR, CGA, RSPO1, SHBG, SOX9, SRD5A2
346,xx ovotesticular disorder of sex development11.9
446xx sex reversal 111.6
5palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal11.5
646xy sex reversal 111.3
746,xx testicular disorder of sex development10.4
8leech infestation10.3
9actg2-related disorders10.3SRY, WNT4
10breast cancer10.3
11gonadal dysgenesis xy type associated anomalies10.3
12swyer syndrome10.3
13palmoplantar keratoderma-xx sex reversal-predisposition to squamous cell carcinoma syndrome10.3
14mixed gonadal dysgenesis10.3SHBG, SRY
15nodular neuronal heterotopia10.2SOX9, SRY
16dysmorphism-short stature-deafness-disorder of sex development syndrome10.2SOX9, SRY
1748,xxxy syndrome10.2SOX9, SRY
1846 xx gonadal dysgenesis10.2SOX9, SRY
19hepatitis10.2
20swyer-james syndrome10.2SOX9, SRY
21breast-ovarian cancer, familial, 210.2SOX9, SRY
22delayed sleep phase syndrome10.2SOX9, SRY
23asthma10.2
24neuronitis10.2
25short qt syndrome10.1SOX9, SRY
26adenocarcinoma10.1
27thyroiditis10.1
28meacham syndrome10.1SOX9, SRY
29craniofrontonasal dysplasia10.1AR, SHBG
30penile cancer10.1SHBG, WNT4
31alternating hemiplegia of childhood10.1SOX9, SRY
32movement disease10.1AR, SRY
33ehlers-danlos syndrome progeroid type10.1AR, SHBG
34urinary schistosomiasis10.1SHBG, SRY, WNT4
35lymphoma10.1
36sarcoma10.1
37prostatitis10.1
38angioedema10.1
39melanoma10.1
40cerebritis10.1
41eosinophilia10.1
42anorectal atresia10.1CGA, SRY
43scleromalacia perforans10.0AR, SHBG
44mixed connective tissue disease10.0SHBG, SRY
45testicular spermatocytic seminoma10.0CGA, SRY
46siberian tick typhus10.0AR, SRD5A2
47verrucous keratotic hemangioma10.0AR, SRD5A2
48leukorrhea10.0AR, SRD5A2
49rheumatoid arthritis10.0
50hepatitis c virus10.0

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Symptoms for Hermaphroditism

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Drugs & Therapeutics for Hermaphroditism

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Drugs for Hermaphroditism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Docetaxelapproved, investigational, Approved May 1996Phase 31844114977-28-5148124, 9877265
Synonyms:
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoate
(2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
01885_FLUKA
114977-28-5
4-(Acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
AC-383
AC1L3WHJ
ANX-514
BIND-014
C11231
CHEBI:4672
CHEMBL92
CID148124
D07866
DB01248
Docefrez
Docetaxel
Docetaxel (INN)
Docetaxel anhydrous
Docetaxel, Trihydrate
EmDOC
 
HMS2089K08
InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,5
MolPort-003-847-005
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-Boc-10-deacetyl taxol
NSC-628503
PSMA-targeted docetaxel nanoparticle
RP-56976
SDP-014
TXL
Taxotere
Taxotere (TN)
Taxotere(R)
XRP-6976L
docetaxel
docetaxel 114977-28-5
nchembio.188-comp8
nchembio.2007.34-comp7
nchembio.573-comp11
nchembio853-comp8
2Tubulin ModulatorsPhase 34279
3
ramucirumabPhase 362
Synonyms:
IMC-1121B
 
IMC-3G3
ramucirumab
4Antimitotic AgentsPhase 34296
5
Epinephrineapproved83451-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenaclick
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Auvi-q
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine bitartrate
Epinephrine chloride
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr
Epipen Jr.
Epipen Jr. Auto-Injector
Epipen jr
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
 
Esphygmogenina
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
Primatene Mist Refill
Prime Asthma Relief
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
6Anti-Inflammatory Agents, Non-Steroidal3549
7Antirheumatic Agents8496
8Anti-Inflammatory Agents8478
9Peripheral Nervous System Agents18510
10Psychotropic Drugs5501
11Epinephryl borate834
12Racepinephrine834
13Analgesics9358
14Analgesics, Non-Narcotic5184

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Ramucirumab (LY3009806) Plus Docetaxel in Participants With Urothelial CancerRecruitingNCT02426125Phase 3
2Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast CancerRecruitingNCT02474641Phase 3
3Qualitative Research on Women With Congenital Adrenal HyperplasiaCompletedNCT00559078
4Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in FranceCompletedNCT01211652
5National Survey on AsthmaCompletedNCT00770250
6Decision Support for Parents Receiving Information About Child's Rare DiseaseRecruitingNCT01875640
7Gene Polymorphisms Influencing Steroid Synthesis and ActionWithdrawnNCT00485186

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

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Anatomical Context for Hermaphroditism

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MalaCards organs/tissues related to Hermaphroditism:

33
Endothelial, Breast, Lung, Heart, T cells, Prostate, B cells

Animal Models for Hermaphroditism or affiliated genes

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MGI Mouse Phenotypes related to Hermaphroditism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.3AR, CGA, RSPO1, SOX9, SRD5A2, WNT4
2MP:00053797.2AR, CGA, RSPO1, SOX9, SRD5A2, WNT4

Publications for Hermaphroditism

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Articles related to Hermaphroditism:

(show top 50)    (show all 440)
idTitleAuthorsYear
1
Coronavirus NL63-induced Adult Respiratory Distress Syndrome. (26720790)
2016
2
Unusual sites of cystic lymphangioma in children. (25282458)
2014
3
Effect of intranasal azelastine on substance P release in perennial nonallergic rhinitis patients. (24274229)
2013
4
Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice. (23942050)
2013
5
Central and peripheral corneal thinning in keratoconus. (22562062)
2013
6
Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma. (23479508)
2013
7
Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases. (23700441)
2013
8
Acute activation of I^2-adrenergic receptor regulates focal adhesions through I^Arrestin2- and p115RhoGEF protein-mediated activation of RhoA. (22500016)
2012
9
Role of anti-tumor necrosis factor-alpha blockers in inducing lupus erythematosus tumidus in "rhupus syndrome". (21632691)
2011
10
Transforming growth factor beta-3 and environmental factors and cleft lip with/without cleft palate. (20408761)
2010
11
Suppressed or recovered intensities analysis in site-directed (13)C NMR: assessment of low-frequency fluctuations in bacteriorhodopsin and D85N mutants revisited. (19615331)
2010
12
EGFR protein overexpression and gene copy number increases in oral tongue squamous cell carcinoma. (19332367)
2009
13
Persistent MA1llerian duct syndrome. (19805969)
2009
14
Gene expression analysis of human fetal ovarian primordial follicle formation. (19258411)
2009
15
The relationship between C-reactive protein and subclinical carotid arteriosclerosis in military pilots]. (19583145)
2009
16
Long-term haloperidol treatment (but not risperidone) enhances addiction-related behaviors in mice: role of dopamine D2 receptors. (19298320)
2009
17
Growth in Noonan syndrome. (20029234)
2009
18
Elevated PYY is associated with energy deficiency and indices of subclinical disordered eating in exercising women with hypothalamic amenorrhea. (18929607)
2009
19
Serial proton MR spectroscopy and diffusion tensor imaging in infantile Balo's concentric sclerosis. (18958461)
2009
20
The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells. (18426800)
2008
21
Endoscopic surgery for nasal glioma mimicking encephalocele in infancy. (19412410)
2008
22
Heart hypertrophy and heart failure--experimental findings for arrhythmogenesis]. (19085808)
2008
23
Caveolin-1 in meningiomas: expression and clinico-pathological correlations. (16850311)
2006
24
Is combination antifungal therapy for invasive aspergillosis a necessity in hematopoietic stem-cell transplant recipients? (16804386)
2006
25
The prevalence and clinical implications of c-kit expression in plasma cell myeloma. (16623778)
2006
26
Creation of GPCR-based chemical sensors by directed evolution in yeast. (16263727)
2006
27
EGFR as a target: rationale for therapy. (16616281)
2006
28
The role of protein-tyrosine phosphatase 1B in integrin signaling. (15866871)
2005
29
Central serous chorioretinopathy and glucocorticoids. (14711450)
2004
30
CD80 gene therapy for lymph node involvement by gastric carcinoma. (15492821)
2004
31
Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. (14661058)
2004
32
Spindle cell rhabdomyosarcoma of the tongue in an infant: a case report with emphasis on differential diagnosis of childhood spindle cell lesions. (15462501)
2004
33
Cutting edge: expansion of the KIR locus by unequal crossing over. (12928362)
2003
34
Chromosomal mapping of HCaRG, a novel hypertension-related, calcium-regulated gene. (11871861)
2002
35
Retinoic acid inhibits inducible nitric oxide synthase expression in 3T3-L1 adipocytes. (12526099)
2002
36
Arachnoiditis ossificans: MR imaging features in five patients. (11461883)
2001
37
Clinical, biochemical and molecular genetic data in five children with Gitelman's syndrome. (11456284)
2001
38
Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. (10614630)
2000
39
Stable isotope dilution analysis of human urinary metabolites of 17alpha-methyltestosterone. (10872596)
2000
40
The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro. (10427990)
1999
41
Current concept of the role of monocytes/macrophages in inflammatory bowel disease--balance of proinflammatory and immunosuppressive mediators. (9759608)
1998
42
FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces. (9769171)
1998
43
Stalling of DNA methyltransferase in chromosome stability and chromosome remodelling (Review). (9852213)
1998
44
Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication. (8523588)
1996
45
Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. (8747461)
1995
46
Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. (8132347)
1994
47
Inhibition of cdc2 activation by INH/PP2A. (8049524)
1994
48
Characterization of 4-hydroxyphenylpyruvate dioxygenase. Primary structure of the Pseudomonas enzyme. (1572351)
1992
49
Lymphohematopoiesis: role of growth factors in leukemogenesis and therapy. (2228899)
1990
50
Re: Infantile hypertrophic pyloric stenosis. (3744758)
1986

Variations for Hermaphroditism

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Expression for genes affiliated with Hermaphroditism

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Search GEO for disease gene expression data for Hermaphroditism.

Pathways for genes affiliated with Hermaphroditism

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GO Terms for genes affiliated with Hermaphroditism

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Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1male sex determinationGO:003023810.0SOX9, SRY
2cellular response to transforming growth factor beta stimulusGO:007156010.0SOX9, WNT4
3sex differentiationGO:000754810.0AR, WNT4
4cell fate commitmentGO:00451659.9SOX9, WNT4
5prostate gland developmentGO:00308509.8AR, SOX9
6epithelial to mesenchymal transitionGO:00018379.7SOX9, WNT4
7cell differentiationGO:00301549.5SOX9, SRY, WNT4
8male gonad developmentGO:00085849.4SOX9, SRD5A2, WNT4
9positive regulation of transcription, DNA-templatedGO:00458938.8AR, SOX9, SRY, WNT4
10cell-cell signalingGO:00072678.6AR, CGA, SRD5A2

Sources for Hermaphroditism

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet