MCID: HRM002
MIFTS: 38

Hermaphroditism malady

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Hermaphroditism

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Summaries for Hermaphroditism

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MalaCards based summary: Hermaphroditism is related to 46xx sex reversal 1 and palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal. An important gene associated with Hermaphroditism is SRY (Sex Determining Region Y), and among its related pathways are Deactivation of the beta-catenin transactivating complex and Regulation of Androgen receptor activity. Affiliated tissues include testes, uterus and testis, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Related Diseases for Hermaphroditism

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Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
146xx sex reversal 111.8
2palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal11.4
3pseudohermaphroditism11.3
4leech infestation10.8
546xy sex reversal 110.8
68p23.1 duplication syndrome10.2SOX9, SRY
7spermatogenic failure, y-linked, 110.2SOX9, SRY
8brucella melitensis brucellosis10.2SOX9, SRY
9abl1 kd-related altered drug metabolism10.2SRY, WNT4
10autosomal dominant optic atrophy and late-onset deafness10.2SOX9, SRY
11orofaciodigital syndrome x10.2SOX9, SRY
12alveolar soft-part sarcoma10.2SOX9, SRY
13cone dystrophy10.2SOX9, SRY
14borderline personality disorder10.1AR, SRD5A2
15deafness, autosomal recessive 5110.1SOX9, SRY
16esophagus sarcoma10.1AR, SRY
17third ventricle chordoid glioma10.1AR, SRD5A2
18dystonia-parkinsonism, x-linked10.1AR, SHBG
19ulceroglandular tularemia10.0AR, SHBG
20antisynthetase syndrome10.0CGA, SRY
2146 xx gonadal dysgenesis10.0SOX9, SRY, WNT4
22skin hemangioma10.0AR, SRD5A2
23glioblastoma mesenchymal subtype10.0AR, SHBG
24adenosquamous cell lung carcinoma10.0AR, SRY
25gonadal dysgenesis10.0
26exocervical carcinoma10.0AR, SHBG
27malignant teratocarcinosarcoma10.0AR, CGA
28acute gonococcal salpingitis10.0SHBG, SRY, WNT4
29gonadoblastoma9.9
30sphingolipidosis9.9AR, SHBG, SRY
31capillary lymphangioma9.9AR, SHBG, SRY
32leukoencephalopathy with ataxia9.9AR, SHBG, SRD5A2
33avoidant personality disorder9.9AR, SHBG, SRY
34gaucher's disease9.9AR, SHBG
3546,xx testicular disorder of sex development9.9
36trachea carcinoma in situ9.9CGA, SHBG
37splenic disease9.9CGA, SOX9, SRY
38inguinal hernia9.9
39benign essential hypertension9.9AR, SOX9, SRD5A2, SRY
40periodic fever, aphthous stomatitis, pharyngitis and adenitis9.8AR, CGA, SRD5A2
41epidural spinal canal meningioma9.8CGA, SHBG
42hypospadias9.8
43mixed gonadal dysgenesis9.8
44seminoma9.8
45pelvic muscle wasting9.8SHBG, WNT4
46farmer's lung9.8SHBG, SOX9, SRY, WNT4
47gonadal dysgenesis, xy type, with associated anomalies9.8
4846 xy gonadal dysgenesis9.8
49retroperitoneal sarcoma9.8CGA, SHBG
50breast myoepithelial neoplasm9.7AR, CGA, SHBG

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Symptoms & Phenotypes for Hermaphroditism

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MGI Mouse Phenotypes related to Hermaphroditism according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1AR, CGA, RSPO1, SOX9, SRD5A2, WNT4
2MP:00053897.4AR, CGA, RSPO1, SOX9, SRD5A2, WNT4

Drugs & Therapeutics for Hermaphroditism

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Drugs for Hermaphroditism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Epinephrineapproved, vet_approved98551-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
2Respiratory System Agents4997
3Racepinephrine985
4Psychotropic Drugs6430
5Vasoconstrictor Agents2122
6Analgesics11733
7Antirheumatic Agents10956
8Anti-Inflammatory Agents, Non-Steroidal4443
9Anti-Inflammatory Agents10729
10Analgesics, Non-Narcotic6501
11Peripheral Nervous System Agents23689
12Neurotransmitter Agents18340
13Adrenergic beta-Agonists1714
14Adrenergic alpha-Agonists1734
15Adrenergic Agonists3027
16Anti-Asthmatic Agents3488
17Autonomic Agents10150
18Mydriatics811
19Epinephryl borate985
20Bronchodilator Agents2965
21Adrenergic Agents5352

Interventional clinical trials:

idNameStatusNCT IDPhase
1Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast CancerRecruitingNCT02474641Phase 3
2Qualitative Research on Women With Congenital Adrenal HyperplasiaCompletedNCT00559078
3Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in FranceCompletedNCT01211652
4National Survey on AsthmaCompletedNCT00770250
5Resilience Against Depression Disparities (Also Known as Resilience Education to Reduce Depression Disparities)RecruitingNCT02986126
6Decision Support for Parents Receiving Information About Child's Rare DiseaseActive, not recruitingNCT01875640
7Reducing LGBTQ Adolescent SuicideEnrolling by invitationNCT02875535
8Gene Polymorphisms Influencing Steroid Synthesis and ActionWithdrawnNCT00485186

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

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Anatomical Context for Hermaphroditism

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MalaCards organs/tissues related to Hermaphroditism:

36
Testes, Uterus, Testis, Kidney, Pituitary, Ovary, Cervix

Publications for Hermaphroditism

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Articles related to Hermaphroditism:

(show top 50)    (show all 446)
idTitleAuthorsYear
1
Rediscovering hermaphroditism in Grammatidae with the description of the testicular gland in Brazilian Basslet Gramma brasiliensis. (27097082)
2016
2
Hermaphroditism in Leonardo da Vinci's Drawing "Angel in the Flesh" (1513-1515). (26980592)
2016
3
Hermaphroditism in a Roman fresco from Herculaneum (first century A.D.), National Archaeological Museum, Naples, Italy. (27412518)
2016
4
Persistence of Reduced Androgenic Glands after Protandric Sex Change Suggests a Basis for Simultaneous Hermaphroditism in a Caridean Shrimp. (27132133)
2016
5
The persistence of memory"-Hermaphroditism in nematodes. (27291983)
2016
6
Gonad development and hermaphroditism in the ascidian Botryllus schlosseri. (27228546)
2016
7
A case of true hermaphroditism presenting as a testicular tumour. (25774314)
2015
8
The Basement Membrane and the Sex Establishment in the Juvenile Hermaphroditism During Gonadal Differentiation of the Gymnocorymbus ternetzi (Teleostei: Characiformes: Characidae). (26386207)
2015
9
Selfish male-determining element favors the transition from hermaphroditism to androdioecy. (25643740)
2015
10
Direct reciprocity stabilizes simultaneous hermaphroditism at high mating rates: A model of sex allocation with egg trading. (26150086)
2015
11
7- OVOTESTICULAR DSD (TRUE HERMAPHRODITISM). (25105460)
2014
12
Embryology and adult urology - Not always mutually exclusive: A case report on true hermaphroditism at an adult urology clinic. (25295140)
2014
13
Evidence of Hermaphroditism and Sex Ratio Distortion in the Fungal Feeding Nematode Bursaphelenchus okinawaensis. (25122669)
2014
14
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. (24742721)
2014
15
A small XY chromosomal region explains sex determination in wild dioecious V. vinifera and the reversal to hermaphroditism in domesticated grapevines. (25179565)
2014
16
Histological and genetic characterization of true hermaphroditism in Korean pigs. (23018792)
2013
17
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. (23727055)
2013
18
Linking micromorphism, brooding, and hermaphroditism in brachiopods: insights from Caribbean Argyrotheca (Brachiopoda). (23400897)
2013
19
Reproductive cycle and strategy of Anodonta anatina (L., 1758): notes on hermaphroditism. (23776103)
2013
20
Phylogenetic perspectives on the evolution of functional hermaphroditism in teleost fishes. (23817661)
2013
21
Female pseudo-hermaphroditism with cloacal malformation and related anomalies in a dog. (23543931)
2012
22
The role of androdioecy and gynodioecy in mediating evolutionary transitions between dioecy and hermaphroditism in the animalia. (23206127)
2012
23
True hermaphrodite presenting as primary amenorrhea. (22837933)
2012
24
Sequential hermaphroditism and personality in a clonal vertebrate: the mangrove killifish. (22365923)
2012
25
Iatrogenic androgenetic alopecia in a male phenotype 46XX true hermaphrodite. (21729028)
2012
26
Back-and-forth hermaphroditism: phylogenetic context of reproductive system evolution in subdioecious Daphne laureola. (21644956)
2011
27
Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite. (22070612)
2011
28
True hermaphroditism: first evidence of an ovotestis in a cetacean species. (20708743)
2011
29
A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat. (20861501)
2011
30
The evolution of hermaphroditism by an infectious male-derived cell lineage: an inclusive-fitness analysis. (21750383)
2011
31
Molecular mechanisms underlying sex change in hermaphroditic groupers. (20467860)
2010
32
Insights into species divergence and the evolution of hermaphroditism from fertile interspecies hybrids of Caenorhabditis nematodes. (20823339)
2010
33
Hermaphroditism among dioecious Tagelus plebeius (Lightfoot, 1786) (Mollusca, Psammobiidae) and Iphigenia brasiliana (Lamarck, 1818) (Mollusca, Donacidae) on the Cachoeira River estuary, IlhAcus, Bahia, Brazil. (20231968)
2010
34
Evidence for hermaphroditism in the Squalius alburnoides allopolyploid fish complex. (20559019)
2010
35
A fungal parasite regulates a putative female-suppressor gene homologous to maize tasselseed2 and causes induced hermaphroditism in male buffalograss. (20121446)
2010
36
Expression of R-ras oncogenes in the hermaphroditic fish Kryptolebias marmoratus, exposed to endocrine disrupting chemicals. (19000778)
2009
37
Chimerism in black southern African patients with true hermaphroditism 46,XX/47XY,+21 and 46,XX/46,XY. (19154517)
2009
38
Surgical treatment of hermaphroditism: experience with 25 cases. (19806042)
2009
39
Evolutionary transitions among dioecy, androdioecy and hermaphroditism in limnadiid clam shrimp (Branchiopoda: Spinicaudata). (19702888)
2009
40
Accessory male investment can undermine the evolutionary stability of simultaneous hermaphroditism. (19605385)
2009
41
Pure ovarian choriocarinoma mimicking ectopic pregnancy in true hermaphroditism. (19363709)
2009
42
Molecular evolution in Panagrolaimus nematodes: origins of parthenogenesis, hermaphroditism and the Antarctic species P. davidi. (19149894)
2009
43
Ovotesticular disorder of sexual development (true hermaphroditism). (18822450)
2009
44
Expression of gonadotropin alpha, follicle-stimulating hormone beta, and luteinizing hormone beta genes of the hermaphroditic fish Kryptolebias marmoratus exposed to octylphenol, 17beta estradiol, and tamoxifen. (19456401)
2009
45
Sry-negative XX true hermaphroditism in a roe deer. (18524504)
2009
46
Evolutionary perspectives on hermaphroditism in fishes. (19684459)
2009
47
Diagnosis of true hermaphroditism in a fetus with acampomelic campomelic dysplasia. (19253311)
2009
48
Bilateral gonadoblastomas with a left sided dysgerminoma in a true hermaphrodite (disorder of sexual differentiation) with 46, XY karyotype. (18846912)
2008
49
Gonadotropin-releasing hormone receptor (GnRHR) gene expression is differently modulated in gender types of the hermaphroditic fish Kryptolebias marmoratus by endocrine disrupting chemicals. (18280221)
2008
50
Salmacisia, a new genus of Tilletiales: reclassification of Tilletia buchloA18488354)
2008

Variations for Hermaphroditism

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Expression for genes affiliated with Hermaphroditism

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Search GEO for disease gene expression data for Hermaphroditism.

Pathways for genes affiliated with Hermaphroditism

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GO Terms for genes affiliated with Hermaphroditism

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Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1male sex determinationGO:003023810.5SOX9, SRY
2positive regulation of male gonad developmentGO:200002010.5SOX9, SRY
3branching involved in ureteric bud morphogenesisGO:000165810.4SOX9, WNT4
4cell fate commitmentGO:004516510.4SOX9, WNT4
5cellular response to transforming growth factor beta stimulusGO:007156010.4SOX9, WNT4
6epithelial to mesenchymal transitionGO:000183710.4SOX9, WNT4
7androgen biosynthetic processGO:000670210.4SRD5A2, WNT4
8negative regulation of epithelial cell proliferationGO:005068010.3AR, SOX9
9prostate gland developmentGO:003085010.2AR, SOX9
10renal vesicle inductionGO:007203410.1SOX9, WNT4
11cell differentiationGO:00301549.6SOX9, SRD5A2, SRY, WNT4
12tertiary branching involved in mammary gland duct morphogenesisGO:00607489.5AR, WNT4
13positive regulation of transcription, DNA-templatedGO:00458939.5AR, SOX9, SRY, WNT4
14male gonad developmentGO:00085849.4AR, SOX9, SRD5A2, WNT4
15cell-cell signalingGO:00072679.4AR, CGA, SRD5A2
16regulation of transcription from RNA polymerase II promoterGO:00063578.8AR, CGA, SOX9, SRY
17sex differentiationGO:00075488.7AR, SRD5A2, SRY, WNT4

Molecular functions related to Hermaphroditism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen bindingGO:000549710.0AR, SHBG
2steroid bindingGO:00054969.8AR, SHBG
3transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:00037059.8SOX9, SRY
4receptor bindingGO:00051029.5AR, RSPO1, WNT4

Sources for Hermaphroditism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet