MCID: HRM002
MIFTS: 38

Hermaphroditism malady

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Hermaphroditism

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Summaries for Hermaphroditism

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MalaCards based summary: Hermaphroditism is related to mixed gonadal dysgenesis and 46xx sex reversal 1. An important gene associated with Hermaphroditism is SRY (Sex Determining Region Y), and among its related pathways are Deactivation of the beta-catenin transactivating complex and Regulation of Androgen receptor activity. Affiliated tissues include testes, breast and testis, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Related Diseases for Hermaphroditism

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Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1mixed gonadal dysgenesis28.9SHBG, SOX9, SRY, WNT4
246xx sex reversal 111.8
3palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal11.4
4pseudohermaphroditism11.2
5leech infestation10.8
646xy sex reversal 110.8
7spermatogenic failure, y-linked, 110.4SOX9, SRY
8drug-induced vasculitis10.4SOX9, SRY
948,xxxy syndrome10.3SOX9, SRY
10farmer's lung10.3SOX9, SRY
11prostate adenocarcinoma10.3SOX9, SRY
12abca1-related disorders10.3SRY, WNT4
13hydronephrosis, congenital, with cleft palate, characteristic facies, hypotonia, and mental retardation10.3SOX9, SRY
14tetraamelia with pulmonary hypoplasia10.3CGA, SRY
15alveolar soft-part sarcoma10.2SOX9, SRY
16multiple synostoses syndrome10.2SOX9, SRY
17gastrojejunal ulcer10.2AR, SRD5A2
18prolapse of lacrimal gland10.2AR, SRY
19vaginal discharge10.1AR, SRD5A2
20meacham syndrome10.1SOX9, SRY
21adult brainstem gliosarcoma10.1AR, SRY
22gonadal dysgenesis10.0
23dystonia-parkinsonism, x-linked10.0AR, SHBG
24glioblastoma classical subtype10.0AR, SHBG
25gonadoblastoma9.9
26pleural empyema9.9CGA, SHBG
2746,xx testicular disorder of sex development9.9
28dental pulp necrosis9.9SHBG, WNT4
29inguinal hernia9.9
30sideroblastic anemia pyridoxine-responsive autosomal recessive9.8AR, CGA, SRY
31hypospadias9.8
32seminoma9.8
33benign paroxysmal positional nystagmus9.8SHBG, SRY, WNT4
34signet ring cell adenocarcinoma9.8SHBG, SRY
35hypogonadism9.8AR, SHBG
36gonadal dysgenesis, xy type, with associated anomalies9.8
3746 xy gonadal dysgenesis9.8
38myoclonic cerebellar dyssynergia9.8AR, SHBG, SRY
39hidradenitis9.8AR, SHBG, SRY
40androgen insensitivity9.7
41klinefelter's syndrome9.7
42vaginitis9.7
43freemartinism9.7
44epilepsy, idiopathic generalized 119.7AR, SHBG, SRD5A2
45candidiasis9.7AR, SHBG, SRY
46cerebellar vermis medulloblastoma9.7AR, SHBG
47tooth disease9.6AR, SOX9, SRD5A2, SRY
48myelodysplastic syndrome9.6
49campomelic dysplasia9.6
50cryptorchidism9.6

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Symptoms for Hermaphroditism

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Drugs & Therapeutics for Hermaphroditism

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Drugs for Hermaphroditism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ramucirumabapproved, investigationalPhase 374947687-13-0
Synonyms:
IMC-1121B
 
IMC-3G3
ramucirumab
2
Docetaxelapproved, investigational, Approved May 1996Phase 31918114977-28-5148124, 9877265
Synonyms:
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoate
(2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
01885_FLUKA
114977-28-5
4-(Acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
AC-383
AC1L3WHJ
ANX-514
BIND-014
C11231
CHEBI:4672
CHEMBL92
CID148124
D07866
DB01248
Docetaxel
Docetaxel (INN)
Docetaxel anhydrous
Docetaxel, Trihydrate
EmDOC
 
HMS2089K08
InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,5
MolPort-003-847-005
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-Boc-10-deacetyl taxol
NSC-628503
PSMA-targeted docetaxel nanoparticle
RP-56976
SDP-014
TXL
Taxotere
Taxotere (TN)
Taxotere(R)
XRP-6976L
docetaxel
docetaxel 114977-28-5
nchembio.188-comp8
nchembio.2007.34-comp7
nchembio.573-comp11
nchembio853-comp8
3Antimitotic AgentsPhase 35498
4
Epinephrineapproved, vet_approved93351-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
5Respiratory System Agents4818
6Psychotropic Drugs6279
7Vasoconstrictor Agents2027
8Racepinephrine933
9Analgesics, Non-Narcotic6260
10Antirheumatic Agents10627
11Anti-Inflammatory Agents, Non-Steroidal4295
12Anti-Inflammatory Agents10355
13Peripheral Nervous System Agents22776
14Analgesics11287
15Epinephryl borate933
16Adrenergic alpha-Agonists1625
17Adrenergic Agonists2877
18Adrenergic Agents5140
19Adrenergic beta-Agonists1640
20Anti-Asthmatic Agents3369
21Mydriatics763
22Bronchodilator Agents2856
23Autonomic Agents9774
24Neurotransmitter Agents17734

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Ramucirumab (LY3009806) Plus Docetaxel in Participants With Urothelial CancerRecruitingNCT02426125Phase 3
2Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast CancerRecruitingNCT02474641Phase 3
3Qualitative Research on Women With Congenital Adrenal HyperplasiaCompletedNCT00559078
4Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in FranceCompletedNCT01211652
5National Survey on AsthmaCompletedNCT00770250
6Decision Support for Parents Receiving Information About Child's Rare DiseaseActive, not recruitingNCT01875640
7Reducing LGBTQ Adolescent SuicideEnrolling by invitationNCT02875535
8Resilience Against Depression Disparities (Also Known as Resilience Education to Reduce Depression Disparities)Not yet recruitingNCT02986126
9Gene Polymorphisms Influencing Steroid Synthesis and ActionWithdrawnNCT00485186

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

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Anatomical Context for Hermaphroditism

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MalaCards organs/tissues related to Hermaphroditism:

35
Testes, Breast, Testis, Uterus, Kidney, Pituitary, Ovary

Animal Models for Hermaphroditism or affiliated genes

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MGI Mouse Phenotypes related to Hermaphroditism:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1AR, CGA, RSPO1, SOX9, SRD5A2, WNT4
2MP:00053897.4AR, CGA, RSPO1, SOX9, SRD5A2, WNT4

Publications for Hermaphroditism

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Articles related to Hermaphroditism:

(show top 50)    (show all 446)
idTitleAuthorsYear
1
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. (24742721)
2014
2
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. (23727055)
2013
3
Evolutionary transitions among dioecy, androdioecy and hermaphroditism in limnadiid clam shrimp (Branchiopoda: Spinicaudata). (19702888)
2009
4
Surgical treatment of hermaphroditism: experience with 25 cases. (19806042)
2009
5
Sry-negative XX true hermaphroditism in a roe deer. (18524504)
2009
6
Expression of R-ras oncogenes in the hermaphroditic fish Kryptolebias marmoratus, exposed to endocrine disrupting chemicals. (19000778)
2009
7
First colored illustration and detailed description of hermaphroditism by a Turkish surgeon, Serefeddin SabuncuoA9lu, in the 15th century. (18046159)
2007
8
Spontaneous ovulation in a true hermaphrodite with normal male phenotype and a rare 46,XX/47,XXY Klinefelter's mosaic karyotype. (17389808)
2007
9
True hermaphroditism in six female littermates after administration of synthetic androgens to a pregnant bitch. (16420323)
2006
10
Testing three models on the adaptive significance of protandric simultaneous hermaphroditism in a marine shrimp. (17089968)
2006
11
Invasive squamous cell carcinoma of the vagina in the setting of true hermaphroditism. (16171851)
2006
12
Screening for mutations in the WNT-4 gene in patients with 46,XX true hermaphroditism. (15589122)
2004
13
Reproductive uncertainty and the relative competitiveness of simultaneous hermaphroditism versus dioecy. (12858266)
2003
14
SRY gene transferred to the long arm of the X chromosome in a Y- positive XX true hermaphrodite. (10602113)
2000
15
True hermaphroditism in a horned goat with 60XX/60XY chimerism. (10907580)
2000
16
True hermaphroditism associated with microphthalmia. (10037254)
1999
17
Vaginal stone in a male patient with true hermaphroditism. (9488939)
1997
18
True hermaphroditism in a wild sheep: A clinical report. (16726991)
1991
19
Sexuality and hermaphroditism in fishes. I. Synchronous functional hermaphroditism in the serranid fish Serranus scriba L. (2341087)
1990
20
Case report of hermaphroditism in a rat. (3430932)
1987
21
Lateral hermaphroditism in a dog. (7107494)
1982
22
Gonadoblastoma and dysgerminoma in a true hermaphrodite with a 46,XX karyotype. (7246672)
1981
23
Hermaphroditism. (7398198)
1980
24
True hermaphroditism: etiology and phenotypic considerations. (365271)
1978
25
Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog. (675252)
1978
26
Familial true hermaphroditism. (757014)
1978
27
Report of a case of true hermaphroditism with karyotype 45,X/46,XX/46,X,mar/47,XX,mar. (563432)
1977
28
Letter: Gender identity and hermaphroditism. (1251201)
1976
29
Hermaphroditism associated with unusual gonadal finding in a mentally retarded child. (1236954)
1975
30
A case of true hermaphroditism presenting as an undescended testicle. (4154009)
1974
31
Hormonal and clinical aspects of hermaphroditism and the testicular feminizing syndrome in man. (4399064)
1970
32
True hermaphroditism unassociated with a common urogenital sinus. (5814093)
1969
33
True hermaphroditism with bilateral ovotestes. (5255117)
1969
34
Staff conference: University of Tennessee Hospital: hermaphroditism. (5934680)
1966
35
X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome. (4161595)
1966
36
HERMAPHRODITISM WITH "ATYPICAL" OR "MIXED" GONADAL DYSGENESIS. RELATIONSHIP TO GONADAL NEOPLASM. (14124695)
1964
37
Mixed" gonadal dysgenesis: a variety of hermaphroditism. (13989874)
1963
38
Problems and management of hermaphroditism. (13894000)
1962
39
Female hermaphroditism without virilization. (13465085)
1957
40
Sex differences in human nuclei with particular reference to the Klinefelter syndrome, gonadal agenesis and other types of hermaphroditism. (13381386)
1956
41
Unilateral hermaphroditism in the mouse. (13249096)
1955
42
Hermaphroditism: classification, diagnosis, selection of sex and treatment. (13245335)
1955
43
TRUE HERMAPHRODITISM; a conference on the management of one patient. (13164000)
1954
44
Hermaphroditism. (13164736)
1954
45
True hermaphroditism. (14888497)
1952
46
A case of hermaphroditism. (14821342)
1951
47
True hermaphroditism. (20279555)
1946
48
TRUE HERMAPHRODITISM: REPORT OF A CASE WITH NECROPSY. (17856731)
1936
49
A Case of Malformation Assumed to be True Hermaphroditism. (19970086)
1933
50
Case of Hermaphroditism in a Common Frog (Rana temporaria). (17231850)
1890

Variations for Hermaphroditism

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Expression for genes affiliated with Hermaphroditism

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Search GEO for disease gene expression data for Hermaphroditism.

Pathways for genes affiliated with Hermaphroditism

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GO Terms for genes affiliated with Hermaphroditism

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Cellular components related to Hermaphroditism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear transcription factor complexGO:00447989.8SOX9, SRY

Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1renal vesicle inductionGO:007203410.3SOX9, WNT4
2cell fate commitmentGO:004516510.3SOX9, WNT4
3prostate gland developmentGO:003085010.2AR, SOX9
4cellular response to transforming growth factor beta stimulusGO:007156010.2SOX9, WNT4
5tertiary branching involved in mammary gland duct morphogenesisGO:006074810.2AR, WNT4
6epithelial to mesenchymal transitionGO:000183710.2SOX9, WNT4
7positive regulation of male gonad developmentGO:200002010.1SOX9, SRY
8male sex determinationGO:003023810.1SOX9, SRY
9branching involved in ureteric bud morphogenesisGO:000165810.1SOX9, WNT4
10androgen biosynthetic processGO:000670210.1SRD5A2, WNT4
11negative regulation of epithelial cell proliferationGO:005068010.0AR, SOX9
12sex differentiationGO:00075489.8AR, WNT4
13cell-cell signalingGO:00072679.3AR, CGA, SRD5A2
14positive regulation of transcription, DNA-templatedGO:00458939.0AR, SOX9, SRY, WNT4
15cell differentiationGO:00301548.9SOX9, SRD5A2, SRY, WNT4
16male gonad developmentGO:00085848.8AR, SOX9, SRD5A2, SRY, WNT4

Molecular functions related to Hermaphroditism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen bindingGO:00054979.7AR, SHBG
2transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:00037059.7SOX9, SRY
3steroid bindingGO:00054969.3AR, SHBG

Sources for Hermaphroditism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet