MCID: HRM002
MIFTS: 49

Hermaphroditism malady

Reproductive diseases category

Summaries for Hermaphroditism

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 In biology, a hermaphrodite is an organism that has reproductive organs normally associated with both... more...

MalaCards: Hermaphroditism is related to 46xx sex reversal 1 and hypospadias. An important gene associated with Hermaphroditism is SRY (sex determining region Y), and among its related pathways are Androgen biosynthesis and Metabolism of steroid hormones and vitamin D. The compounds estrogen and epitestosterone have been mentioned in the context of this disorder. Affiliated tissues include testes, uterus and testis, and related mouse phenotypes are growth/size and endocrine/exocrine gland.

Aliases & Classifications for Hermaphroditism

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
See all sources

Related Diseases for Hermaphroditism

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
146xx sex reversal 135.2SRY, SRD5A1
2hypospadias35.1AR, CGA, SRY, SRD5A1, SRD5A2
3mixed gonadal dysgenesis35.1SRD5A1, SRY
4klinefelter's syndrome35.0GNRHR, AR, CGA, SHBG, CYP19A1, SRD5A1
5androgen insensitivity syndrome34.7AR, CGA, SHBG, SRY, SRD5A1, SRD5A2
6cryptorchidism34.7SRD5A1, SRY, CYP19A1, SHBG, CGA, AR
7gynecomastia34.7BRCA2, SRD5A2, SRD5A1, SRY, CYP19A1, SHBG
8gonadal dysgenesis30.4SOX9, SRY
9gonadoblastoma30.3SRY, ZFY
10pseudohermaphroditism30.1AMH, AR, CYP19A1, SRY, SRD5A2
11campomelic dysplasia29.8SRY, SOX9
12amenorrhea29.8AMH, SHBG, SRY
13alopecia29.8SHBG, AR
14sertoli cell tumor29.8AR, CYP19A1
15choriocarcinoma29.8CYP19A1, CGA, GNRHR
16male infertility29.8AR, CGA, SHBG, CYP19A1, SRY
17infertility29.8AMH, GNRHR, AR, CGA, SHBG, CYP19A1
18hyperprolactinemia13.3CGA, SHBG, SRD5A1
19hyperandrogenism13.3AMH, AR, CGA, SHBG, CYP19A1, SRD5A1
20polycystic ovary syndrome13.3AR, CGA, SHBG, CYP19A1, SRD5A1
21androgenic alopecia13.3AR, SHBG, CYP19A1, SRD5A1, SRD5A2
22congenital adrenal hyperplasia13.3SRD5A1, SRY, CYP19A1
23oligospermia13.3AMH, GNRHR, AR, CGA, FSHB, SRD5A1
24azoospermia13.3SRD5A1, SRY, FSHB, ZFY, SHBG, CGA
25anovulation13.3AMH, CGA, SHBG, CYP19A1, SRD5A1
26adenocarcinoma13.3BRCA2, GNRHR, AR, SRD5A1
27adenoma13.3SRD5A1, FSHB, SHBG, CGA, GNRHR
28breast cancer13.3BRCA2, GNRHR, AR, SHBG, CYP19A1, SRD5A1
29impotence13.3SRD5A1, SHBG
30leydig cell tumor13.3CGA, CYP19A1, SRD5A1
31obesity13.3AR, SHBG, SRD5A1
32prostate cancer13.3GNRHR, AR, SRD5A1, SRD5A2
33prostate disease13.3SRD5A1, CYP19A1, AR
34prostatitis13.3SRD5A1
35wilms tumor13.3BRCA2, SOX9, SRY, SRD5A1
36penis agenesis13.3SRD5A2, SRD5A1, CGA, AR
37partial androgen insensitivity syndrome13.3AR, SHBG, CYP19A1, SRD5A1
38seminoma10.1
39freemartinism10.0
40penile disease10.0
41sexual disorder10.0
42vaginitis10.0
43palmoplantar hyperkeratosis and true hermaphroditism10.0
44premature ovarian failure10.0AMH
45testicular disease10.0SRY
46thyroiditis10.0CGA
47conduct disorder10.0CGA
48prostatic hypertrophy10.0AR
49hypoactive sexual desire disorder10.0SHBG
50insulin resistance10.0SHBG

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Clinical Features for Hermaphroditism

About this section

Drugs & Therapeutics for Hermaphroditism

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Hermaphroditism

Drug clinical trials:

Search ClinicalTrials for Hermaphroditism

Search NIH Clinical Center for Hermaphroditism

Search CenterWatch for Hermaphroditism

Genetic Tests for Hermaphroditism

About this section

Anatomical Context for Hermaphroditism

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Hermaphroditism:

32
Testes, Uterus, Testis, Kidney, Pituitary, Ovary, Cervix

Animal Models for Hermaphroditism or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Hermaphroditism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.2GNRHR, SOX9, CSNK1D, AR, RBFOX1, CGA
2MP:00053797.1AR, SOX9, GNRHR, AMH, BRCA2, CGA
3MP:00053896.9RSPO1, BRCA2, AMH, GNRHR, SOX9, AR

Publications for Hermaphroditism

About this section
Sources:
50PubMed
See all sources

Articles related to Hermaphroditism:

(show top 50)    (show all 431)
idTitleAuthorsYear
1
Phylogenetic perspectives on the evolution of functional hermaphroditism in teleost fishes. (23817661)
2013
2
Female pseudo-hermaphroditism with cloacal malformation and related anomalies in a dog. (23543931)
2012
3
Expression of R-ras oncogenes in the hermaphroditic fish Kryptolebias marmoratus, exposed to endocrine disrupting chemicals. (19000778)
2009
4
Molecular evolution in Panagrolaimus nematodes: origins of parthenogenesis, hermaphroditism and the Antarctic species P. davidi. (19149894)
2009
5
Salmacisia, a new genus of Tilletiales: reclassification of Tilletia buchloA18488354)
2008
6
A male phenotype (XY) hermaphrodite treated for seminoma, fathered a healthy child by IVF-ICSI technique. (18648929)
2008
7
Perchlorate induces hermaphroditism in threespine sticklebacks. (16916028)
2006
8
The evolution of gender specialization from dimorphic hermaphroditism: paths from heterodichogamy to gynodioecy and androdioecy. (16739449)
2006
9
True hermaphroditism-the importance of ultrasonic assessment. (15937973)
2005
10
Screening for mutations in the WNT-4 gene in patients with 46,XX true hermaphroditism. (15589122)
2004
11
Granulocytic sarcoma of the ovotestis: an association of myelodysplastic syndrome and hermaphroditism. (15360014)
2004
12
True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene. (12793612)
2003
13
Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence. (12676617)
2003
14
Persistence of Mhc heterozygosity in homozygous clonal killifish, Rivulus marmoratus: implications for the origin of hermaphroditism. (12524349)
2002
15
Management of the African child with true hermaphroditism. (11172444)
2001
16
Male pseudo-hermaphroditism in a dog: a clinical case. (11321217)
2000
17
True hermaphroditism with 46,XY karyotype and a point mutation in the SRY gene. (7776083)
1995
18
Familial true hermaphroditism: paternal and maternal transmission of true hermaphroditism (46,XX) and XX maleness in the absence of Y-chromosomal sequences. (8262517)
1993
19
True hermaphroditism: sonographic demonstration of ovotestes. (2014286)
1991
20
XX true hermaphroditism in southern African blacks: an enigma of primary sexual differentiation. (3163890)
1988
21
Case report of hermaphroditism in a rat. (3430932)
1987
22
A phenotypic male with true hermaphroditism and a 46,XX/46,XY/47,XXY karyotype. (3594931)
1987
23
True hermaphroditism presenting as intermittent hematuria and groin pain. (3739117)
1986
24
Whistling maids and crowing hens--hermaphroditism in folklore and biology. (7290904)
1981
25
Production of testosterone and estrogen in vitro by gonadal tissue from a 46,XY true hermaphrodite with gonadal failure and gonadoblastoma. (7254737)
1981
26
Hermaphroditism induced in the female chick by testicular grafts. (7390139)
1980
27
Simultaneous hermaphroditism and sexual selection. (16592656)
1979
28
True hermaphroditism: an analytic review with a report of 3 new cases. (1033669)
1976
29
Lateral hermaphroditism in a C3H mouse. (1152420)
1975
30
Pathogenesis of male hermaphroditism. (4444322)
1974
31
Letter: Terminology of hermaphroditism. (4749585)
1973
32
Diagnosis of true hermaphroditism. (5026030)
1972
33
High incidence of true hermaphroditism in the early human embryos. (5163617)
1971
34
Hermaphroditism in a rat. (5520717)
1970
35
Aplasticity of vulvae with reference to normal breeding and development of hermaphroditism in middle white Yorkshire pigs. (5693492)
1968
36
BOVINE FREEMARTINS AND TRUE HERMAPHRODITISM. (14283739)
1965
37
Familial male hermaphroditism with delayed and partial masculinization. (4221283)
1965
38
True hermaphroditism. (5826076)
1965
39
TRUE HERMAPHRODITISM IN CHIMAERIC MICE. (14251483)
1964
40
TRUE HERMAPHRODITISM: 2 CASES. (14139629)
1964
41
Hermaphroditism. (13896599)
1962
42
Congential adrenal hyperplasia producing female hermaphroditism with phallic urethra. (14431843)
1960
43
True hermaphroditism. (13708494)
1960
44
Roentgenological differential diagnosis of simple hypospadia from hypospadia in hermaphroditism]. (13083763)
1953
45
HERMAPHRODITISM. (14888912)
1951
46
Hermaphroditism and its treatment. (15423773)
1950
47
True hermaphroditism; report of a case with an ovotestis, and endocrine studies. (20253406)
1947
48
Hermaphroditism in a Dioicous Hepatic. (16587177)
1927
49
Notes of a Case of Pseudo-hermaphroditism. (19975655)
1912
50
An Example of Incomplete Glandular Hermaphroditism in the Domestic Fowl. (19973312)
1908

Genetic Variations for Hermaphroditism

About this section

Expression for genes affiliated with Hermaphroditism

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hermaphroditism

Search GEO for disease gene expression data for Hermaphroditism.

Pathways for genes affiliated with Hermaphroditism

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 55SinoBiological, 52R&D Systems
See all sources

Compounds for genes affiliated with Hermaphroditism

About this section
Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB
See all sources

Compounds related to Hermaphroditism according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9
2epitestosterone4410.3CGA, SHBG
3ment4410.2SHBG, CYP19A1
4norgestimate44 1111.2AR, SHBG
5formestane4410.2SHBG, CYP19A1
6ganirelix44 2811.1GNRHR, CGA, FSHB
7leuprolide44 59 28 1113.0GNRHR, AR, CGA
8androstanedione44 11 2412.0CYP19A1, SRD5A2
9dutasteride44 1111.0AR, CYP19A1, SRD5A2
10hydroxyflutamide44 2811.0SHBG, CGA, AR
11androstenediol4410.0CYP19A1, SHBG, AR
125alpha-androstane-3alpha,17beta-diol449.9CYP19A1, SHBG, AR
13exemestane49 44 59 1112.9CYP19A1, SHBG, AR
14Drostanolone119.9AR, SHBG, CYP19A1
1517-hydroxyprogesterone44 2410.9CGA, SHBG, CYP19A1
16cyproteroneacetate449.9CYP19A1, SHBG, AR
17levonorgestrel44 59 28 1112.9CYP19A1, SHBG, AR
18nafarelin44 59 28 1112.8GNRHR, CGA, CYP19A1
19Methyltestosterone119.8AR, SHBG, CYP19A1
20buserelin44 28 1111.8GNRHR, CGA, CYP19A1, FSHB
21goserelin44 28 1111.8GNRHR, CGA, SHBG, CYP19A1
22finasteride44 59 11 2412.8SRD5A2, CYP19A1, SHBG, AR
23clomiphene citrate449.7CGA, SHBG, CYP19A1, FSHB
24ketoconazole44 28 11 2412.7CYP19A1, SHBG, AR
253beta-hydroxysteroid449.7AR, CGA, CYP19A1, SRD5A2
2617beta-hydroxysteroid449.7AR, CGA, CYP19A1, SRD5A2
27progestins449.7AR, SHBG, CYP19A1
28flutamide44 59 1111.7AR, CGA, SHBG, CYP19A1
29dehydroepiandrosterone sulfate449.7AR, CGA, SHBG, CYP19A1
30danazol44 11 2411.7CYP19A1, SHBG, AR, GNRHR
31nandrolone44 2410.6AR, SHBG, CYP19A1
32letrozole44 49 59 1112.6AR, CGA, SHBG, CYP19A1
33progestin449.6AR, CGA, SHBG, CYP19A1
34leuprolide acetate449.6GNRHR, CGA, SHBG, CYP19A1, FSHB
35deoxyribonucleic acid449.6GNRHR, ZFY, FSHB, SRY, SRD5A2
36dhea449.5AR, SHBG, CYP19A1
37estrone44 28 11 2412.5CYP19A1, SHBG, AR
38anastrozole44 1110.5CYP19A1, SHBG, CGA
39androstenedione44 2410.5AR, CGA, SHBG, CYP19A1, SRD5A2
40diethylstilbestrol44 28 1111.5AR, CGA, SHBG, CYP19A1
41mifepristone44 59 28 1112.3CYP19A1, SHBG, CGA, AR, AMH
42vitamin d449.3AR, CGA, SHBG, CYP19A1, SRD5A2
43gnrh449.2GNRHR, AR, CGA, SHBG, CYP19A1, FSHB
44dihydrotestosterone44 28 11 2412.1GNRHR, AR, CGA, SHBG, CYP19A1, SRY
45ribonucleic acid448.9GNRHR, SOX9, CGA, FSHB, SRD5A2
46tamoxifen44 49 28 1111.8BRCA2, AMH, GNRHR, AR, CGA, SHBG
47estradiol44 11 2410.3BRCA2, AMH, GNRHR, AR, CGA, SHBG
48progesterone44 59 28 11 2412.2AR, GNRHR, AMH, BRCA2, CGA, SHBG
49steroid448.2BRCA2, GNRHR, SOX9, AR, CGA, SHBG
50testosterone44 59 11 2410.7SRD5A2, BRCA2, AMH, GNRHR, SOX9, AR

GO Terms for genes affiliated with Hermaphroditism

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Hermaphroditism according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1sex determinationGO:00753010.4AMH
2androgen biosynthetic processGO:00670210.3SRD5A2, WNT4
3sex differentiationGO:00754810.2AMH, AR
4positive regulation of male gonad developmentGO:200002010.2SOX9, SRY
5renal vesicle inductionGO:07203410.2SOX9, WNT4
6tertiary branching involved in mammary gland duct morphogenesisGO:06074810.2AR, WNT4
7steroid metabolic processGO:00820210.2SRD5A2, CYP19A1
8prostate gland developmentGO:03085010.1SOX9, AR
9prostate gland growthGO:06073610.0CYP19A1, AR
10peptide hormone processingGO:01648610.0CGA, FSHB
11androgen metabolic processGO:00820910.0SRD5A2, CYP19A1
12positive regulation of canonical Wnt receptor signaling pathwayGO:0902639.9CSNK1E, CSNK1D, WNT4, RSPO1
13female gonad developmentGO:0085859.7BRCA2, WNT4
14male gonad developmentGO:0085849.5SRD5A2, SRY, WNT4, AR, SOX9
15cell-cell signalingGO:0072679.5SRD5A2, WNT4, CGA, AR, AMH
16spermatogenesisGO:0072839.3FSHB, AR, SOX9, BRCA2
17positive regulation of transcription, DNA-dependentGO:0458939.2BRCA2, SOX9, AR, WNT4, SRY
18positive regulation of cell migrationGO:0303359.2FSHB, RRAS2, CGA
19signal transductionGO:0071659.1SOX9, CSNK1E, CSNK1D, AR, CGA, FSHB

Molecular functions related to Hermaphroditism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00386510.3SRD5A2
2cholestenone 5-alpha-reductase activityGO:04775110.2SRD5A2
3hormone activityGO:0051799.8FSHB, CGA, AMH
4androgen bindingGO:0054979.6SHBG, AR

Products for genes affiliated with Hermaphroditism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hermaphroditism

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet