MCID: HRM002
MIFTS: 42

Hermaphroditism

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Hermaphroditism

Summaries for Hermaphroditism

MalaCards based summary : Hermaphroditism is related to 46,xx sex reversal 1 and pseudohermaphroditism. An important gene associated with Hermaphroditism is SRY (Sex Determining Region Y), and among its related pathways/superpathways are Signaling by Wnt and Transcription Androgen Receptor nuclear signaling. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and testis, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 72 In biology, a hermaphrodite is an organism that has reproductive organs and produces gametes normally... more...

Related Diseases for Hermaphroditism

Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 46,xx sex reversal 1 32.7 NR0B1 SOX9 SRY
2 pseudohermaphroditism 32.1 AR SRD5A2
3 gonadoblastoma 30.4 SOX9 SRY
4 mixed gonadal dysgenesis 30.3 SOX9 SRY
5 gonadal dysgenesis 30.0 NR0B1 SOX9 SRY
6 campomelic dysplasia 29.8 SOX9 SRY
7 hypospadias 29.2 AR SOX9 SRD5A2 SRY
8 46 xy gonadal dysgenesis 29.1 NR0B1 SHBG SOX9 SRY WNT4
9 androgenic alopecia 29.1 AR SHBG
10 amenorrhea 29.0 SHBG SRY WNT4
11 gynecomastia 28.8 AR SHBG SRY
12 alopecia, androgenetic, 1 28.8 AR SHBG SRD5A2
13 cryptorchidism, unilateral or bilateral 28.8 AR SHBG SRY
14 androgen insensitivity syndrome 28.4 AR SHBG SRD5A2 SRY
15 palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,xx sex reversal 11.5
16 46,xy sex reversal 1 11.2
17 leech infestation 10.9
18 denys-drash syndrome 10.9
19 testicular disease 10.2 SOX9 SRY
20 persistent mullerian duct syndrome 10.2 SOX9 SRY
21 frasier syndrome 10.1 SOX9 SRY
22 penis agenesis 10.1 AR SRD5A2
23 prostatic hyperplasia, benign 10.1 AR SRD5A2
24 alternating hemiplegia of childhood 10.0 NR0B1 SRY
25 male reproductive system disease 10.0 AR SRY
26 prostate disease 10.0 AR SRD5A2
27 inguinal hernia 10.0
28 46,xy partial gonadal dysgenesis 9.9 NR0B1 SOX9 SRY
29 seminoma 9.9
30 gonadal dysgenesis, xy type, with associated anomalies 9.9
31 hypogonadotropic hypogonadism 9.8
32 vaginitis 9.8
33 freemartinism 9.8
34 47, xxy 9.8 AR SHBG
35 postmenopausal atrophic vaginitis 9.8 AR SHBG
36 androgen insensitivity, partial 9.8 AR SHBG
37 prostatic adenoma 9.8 AR SHBG
38 wilms tumor 1 9.7 AR NR0B1 SRY
39 hyperandrogenism 9.7 SHBG WNT4
40 dermal ridges-off-the-end 9.7
41 hydatidiform mole, recurrent, 1 9.7
42 gonadal agenesis 9.7
43 myelodysplastic syndrome 9.7
44 episodic pain syndrome, familial, 1 9.7
45 wilms tumor 6 9.7
46 alopecia 9.7
47 hepatitis 9.7
48 male infertility 9.7
49 ectopic pregnancy 9.7
50 microphthalmia 9.7

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to Hermaphroditism

Symptoms & Phenotypes for Hermaphroditism

MGI Mouse Phenotypes related to Hermaphroditism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 AR NR0B1 RSPO1 SOX9 SRD5A2 WNT4
2 reproductive system MP:0005389 9.1 AR NR0B1 RSPO1 SOX9 SRD5A2 WNT4

Drugs & Therapeutics for Hermaphroditism

Drugs for Hermaphroditism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2 Racepinephrine Approved 329-65-7
3 Epinephryl borate
4 Adrenergic Agents
5 Adrenergic Agonists
6 Adrenergic alpha-Agonists
7 Adrenergic beta-Agonists
8 Anti-Asthmatic Agents
9 Autonomic Agents
10 Bronchodilator Agents
11 Mydriatics
12 Neurotransmitter Agents
13 Peripheral Nervous System Agents
14 Psychotropic Drugs
15 Respiratory System Agents
16 Vasoconstrictor Agents
17 Analgesics
18 Analgesics, Non-Narcotic
19 Anti-Inflammatory Agents
20 Anti-Inflammatory Agents, Non-Steroidal
21 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast Cancer Recruiting NCT02474641 Phase 3
2 Decision Support for Parents Receiving Information About Child's Rare Disease Completed NCT01875640
3 Qualitative Research on Women With Congenital Adrenal Hyperplasia Completed NCT00559078
4 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
5 National Survey on Asthma Completed NCT00770250
6 Resilience Against Depression Disparities (Also Known as Resilience Education to Reduce Depression Disparities) Recruiting NCT02986126
7 Reducing LGBTQ Adolescent Suicide Enrolling by invitation NCT02875535
8 Gene Polymorphisms Influencing Steroid Synthesis and Action Withdrawn NCT00485186

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

Anatomical Context for Hermaphroditism

MalaCards organs/tissues related to Hermaphroditism:

38
Testes, Breast, Testis, Uterus, Kidney, Pituitary, Ovary

Publications for Hermaphroditism

Articles related to Hermaphroditism:

(show top 50) (show all 453)
# Title Authors Year
1
CRISPR/Cas9-Mediated Mosaic Mutation of<i>SRY</i>Gene Induces Hermaphroditism in Rabbits. ( 29439141 )
2018
2
Draft Genome Sequence of Salmacisia buchloA<ana (Basidiomycota), Which Induces Hermaphroditism in Dioecious Buffalograss. ( 28385853 )
2017
3
Hermaphroditism: an obsolete diagnosis? ( 28500834 )
2017
4
Phase-specific expression of an insulin-like androgenic gland factor in a marine shrimp Lysmata wurdemanni: Implication for maintaining protandric simultaneous hermaphroditism. ( 28235100 )
2017
5
Hermaphroditism in the dash-and-dot goatfish Parupeneus barberinus. ( 28097655 )
2017
6
Histological profiling of gonads depicting protandrous hermaphroditism in Eleutheronema tetradactylum. ( 28474376 )
2017
7
Hermaphroditism in the white spot grouper Epinephelus coeruleopunctatus (Pisces: Serranidae) harvested from Padang City waters, Indonesia. ( 28491284 )
2017
8
Hermaphroditism in Leonardo da Vinci's Drawing "Angel in the Flesh" (1513-1515). ( 26980592 )
2016
9
Hermaphroditism in a Roman fresco from Herculaneum (first century A.D.), National Archaeological Museum, Naples, Italy. ( 27412518 )
2016
10
Rediscovering hermaphroditism in Grammatidae with the description of the testicular gland in Brazilian Basslet Gramma brasiliensis. ( 27097082 )
2016
11
"The persistence of memory"-Hermaphroditism in nematodes. ( 27291983 )
2016
12
Persistence of Reduced Androgenic Glands after Protandric Sex Change Suggests a Basis for Simultaneous Hermaphroditism in a Caridean Shrimp. ( 27132133 )
2016
13
Gonad development and hermaphroditism in the ascidian Botryllus schlosseri. ( 27228546 )
2016
14
The Basement Membrane and the Sex Establishment in the Juvenile Hermaphroditism During Gonadal Differentiation of the Gymnocorymbus ternetzi (Teleostei: Characiformes: Characidae). ( 26386207 )
2015
15
A case of true hermaphroditism presenting as a testicular tumour. ( 25774314 )
2015
16
Direct reciprocity stabilizes simultaneous hermaphroditism at high mating rates: A model of sex allocation with egg trading. ( 26150086 )
2015
17
Selfish male-determining element favors the transition from hermaphroditism to androdioecy. ( 25643740 )
2015
18
A small XY chromosomal region explains sex determination in wild dioecious V. vinifera and the reversal to hermaphroditism in domesticated grapevines. ( 25179565 )
2014
19
Evidence of Hermaphroditism and Sex Ratio Distortion in the Fungal Feeding Nematode Bursaphelenchus okinawaensis. ( 25122669 )
2014
20
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. ( 24742721 )
2014
21
Embryology and adult urology - Not always mutually exclusive: A case report on true hermaphroditism at an adult urology clinic. ( 25295140 )
2014
22
7- OVOTESTICULAR DSD (TRUE HERMAPHRODITISM). ( 25105460 )
2014
23
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. ( 23727055 )
2013
24
Histological and genetic characterization of true hermaphroditism in Korean pigs. ( 23018792 )
2013
25
Linking micromorphism, brooding, and hermaphroditism in brachiopods: insights from Caribbean Argyrotheca (Brachiopoda). ( 23400897 )
2013
26
Reproductive cycle and strategy of Anodonta anatina (L., 1758): notes on hermaphroditism. ( 23776103 )
2013
27
Phylogenetic perspectives on the evolution of functional hermaphroditism in teleost fishes. ( 23817661 )
2013
28
Iatrogenic androgenetic alopecia in a male phenotype 46XX true hermaphrodite. ( 21729028 )
2012
29
The role of androdioecy and gynodioecy in mediating evolutionary transitions between dioecy and hermaphroditism in the animalia. ( 23206127 )
2012
30
True hermaphrodite presenting as primary amenorrhea. ( 22837933 )
2012
31
Female pseudo-hermaphroditism with cloacal malformation and related anomalies in a dog. ( 23543931 )
2012
32
Sequential hermaphroditism and personality in a clonal vertebrate: the mangrove killifish. ( 22365923 )
2012
33
True hermaphroditism: first evidence of an ovotestis in a cetacean species. ( 20708743 )
2011
34
A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat. ( 20861501 )
2011
35
The evolution of hermaphroditism by an infectious male-derived cell lineage: an inclusive-fitness analysis. ( 21750383 )
2011
36
Back-and-forth hermaphroditism: phylogenetic context of reproductive system evolution in subdioecious Daphne laureola. ( 21644956 )
2011
37
Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite. ( 22070612 )
2011
38
Evidence for hermaphroditism in the Squalius alburnoides allopolyploid fish complex. ( 20559019 )
2010
39
Molecular mechanisms underlying sex change in hermaphroditic groupers. ( 20467860 )
2010
40
Hermaphroditism among dioecious Tagelus plebeius (Lightfoot, 1786) (Mollusca, Psammobiidae) and Iphigenia brasiliana (Lamarck, 1818) (Mollusca, Donacidae) on the Cachoeira River estuary, IlhAcus, Bahia, Brazil. ( 20231968 )
2010
41
A fungal parasite regulates a putative female-suppressor gene homologous to maize tasselseed2 and causes induced hermaphroditism in male buffalograss. ( 20121446 )
2010
42
Insights into species divergence and the evolution of hermaphroditism from fertile interspecies hybrids of Caenorhabditis nematodes. ( 20823339 )
2010
43
Evolutionary perspectives on hermaphroditism in fishes. ( 19684459 )
2009
44
Diagnosis of true hermaphroditism in a fetus with acampomelic campomelic dysplasia. ( 19253311 )
2009
45
Chimerism in black southern African patients with true hermaphroditism 46,XX/47XY,+21 and 46,XX/46,XY. ( 19154517 )
2009
46
Evolutionary transitions among dioecy, androdioecy and hermaphroditism in limnadiid clam shrimp (Branchiopoda: Spinicaudata). ( 19702888 )
2009
47
Expression of R-ras oncogenes in the hermaphroditic fish Kryptolebias marmoratus, exposed to endocrine disrupting chemicals. ( 19000778 )
2009
48
Accessory male investment can undermine the evolutionary stability of simultaneous hermaphroditism. ( 19605385 )
2009
49
Sry-negative XX true hermaphroditism in a roe deer. ( 18524504 )
2009
50
Expression of gonadotropin alpha, follicle-stimulating hormone beta, and luteinizing hormone beta genes of the hermaphroditic fish Kryptolebias marmoratus exposed to octylphenol, 17beta estradiol, and tamoxifen. ( 19456401 )
2009

Variations for Hermaphroditism

Expression for Hermaphroditism

Search GEO for disease gene expression data for Hermaphroditism.

Pathways for Hermaphroditism

Pathways related to Hermaphroditism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.32 RSPO1 SOX9 SRY WNT4
2
Show member pathways
11.3 AR SRD5A2 WNT4
3 10.96 SOX9 SRY
4 10.5 AR NR0B1 SRY
5 10.41 AR SHBG

GO Terms for Hermaphroditism

Cellular components related to Hermaphroditism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear speck GO:0016607 8.8 AR NR0B1 SRY

Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.85 AR SOX9 SRY WNT4
2 cell differentiation GO:0030154 9.83 NR0B1 SOX9 SRD5A2 SRY WNT4
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.71 AR NR0B1 SOX9
4 negative regulation of cell differentiation GO:0045596 9.62 NR0B1 WNT4
5 negative regulation of epithelial cell proliferation GO:0050680 9.61 AR SOX9
6 steroid biosynthetic process GO:0006694 9.61 NR0B1 SRD5A2
7 steroid hormone mediated signaling pathway GO:0043401 9.6 AR NR0B1
8 cellular response to transforming growth factor beta stimulus GO:0071560 9.59 SOX9 WNT4
9 cell fate commitment GO:0045165 9.58 SOX9 WNT4
10 intracellular receptor signaling pathway GO:0030522 9.58 AR NR0B1
11 branching involved in ureteric bud morphogenesis GO:0001658 9.57 SOX9 WNT4
12 epithelial to mesenchymal transition GO:0001837 9.56 SOX9 WNT4
13 adrenal gland development GO:0030325 9.52 NR0B1 WNT4
14 prostate gland development GO:0030850 9.51 AR SOX9
15 hypothalamus development GO:0021854 9.49 NR0B1 SRD5A2
16 Leydig cell differentiation GO:0033327 9.48 AR NR0B1
17 androgen biosynthetic process GO:0006702 9.46 SRD5A2 WNT4
18 positive regulation of male gonad development GO:2000020 9.4 SOX9 SRY
19 Sertoli cell differentiation GO:0060008 9.37 NR0B1 SOX9
20 male gonad development GO:0008584 9.35 AR NR0B1 SOX9 SRD5A2 WNT4
21 male sex determination GO:0030238 9.33 NR0B1 SOX9 SRY
22 renal vesicle induction GO:0072034 9.32 SOX9 WNT4
23 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.26 AR WNT4
24 sex differentiation GO:0007548 8.92 AR SRD5A2 SRY WNT4

Molecular functions related to Hermaphroditism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.58 AR RSPO1 WNT4
2 transcription factor binding GO:0008134 9.43 AR NR0B1 SRY
3 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.37 SOX9 SRY
4 steroid hormone receptor activity GO:0003707 9.32 AR NR0B1
5 nuclear receptor activity GO:0004879 9.16 AR NR0B1
6 steroid binding GO:0005496 8.96 AR SHBG
7 androgen binding GO:0005497 8.62 AR SHBG

Sources for Hermaphroditism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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