MCID: HRM002
MIFTS: 49

Hermaphroditism malady

Reproductive diseases category

Summaries for Hermaphroditism

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63Wikipedia, 32MalaCards
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Wikipedia:63 In biology, a hermaphrodite is an organism that has reproductive organs normally associated with both... more...

MalaCards: Hermaphroditism is related to 46xx sex reversal 1 and hypospadias. An important gene associated with Hermaphroditism is SRY (sex determining region Y), and among its related pathways are Androgen biosynthesis and Metabolism of steroid hormones and vitamin D. The compounds estrogen and epitestosterone have been mentioned in the context of this disorder. Affiliated tissues include testes, uterus and testis, and related mouse phenotypes are growth/size and endocrine/exocrine gland.

Aliases & Classifications for Hermaphroditism

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Hermaphroditism

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17GeneCards, 18GeneDecks
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Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
146xx sex reversal 135.2SRY, SRD5A1
2hypospadias35.1AR, CGA, SRY, SRD5A1, SRD5A2
3mixed gonadal dysgenesis35.1SRD5A1, SRY
4klinefelter's syndrome35.0GNRHR, AR, CGA, SHBG, CYP19A1, SRD5A1
5androgen insensitivity syndrome34.7AR, CGA, SHBG, SRY, SRD5A1, SRD5A2
6cryptorchidism34.7SRD5A1, SRY, CYP19A1, SHBG, CGA, AR
7gynecomastia34.7BRCA2, SRD5A2, SRD5A1, SRY, CYP19A1, SHBG
8gonadal dysgenesis30.4SOX9, SRY
9gonadoblastoma30.3SRY, ZFY
10pseudohermaphroditism30.1AMH, AR, CYP19A1, SRY, SRD5A2
11campomelic dysplasia29.8SRY, SOX9
12amenorrhea29.8AMH, SHBG, SRY
13alopecia29.8SHBG, AR
14sertoli cell tumor29.8AR, CYP19A1
15choriocarcinoma29.8CYP19A1, CGA, GNRHR
16male infertility29.8AR, CGA, SHBG, CYP19A1, SRY
17infertility29.8AMH, GNRHR, AR, CGA, SHBG, CYP19A1
18hyperprolactinemia13.3CGA, SHBG, SRD5A1
19hyperandrogenism13.3AMH, AR, CGA, SHBG, CYP19A1, SRD5A1
20polycystic ovary syndrome13.3AR, CGA, SHBG, CYP19A1, SRD5A1
21androgenic alopecia13.3AR, SHBG, CYP19A1, SRD5A1, SRD5A2
22congenital adrenal hyperplasia13.3SRD5A1, SRY, CYP19A1
23oligospermia13.3AMH, GNRHR, AR, CGA, FSHB, SRD5A1
24azoospermia13.3SRD5A1, SRY, FSHB, ZFY, SHBG, CGA
25anovulation13.3AMH, CGA, SHBG, CYP19A1, SRD5A1
26adenocarcinoma13.3BRCA2, GNRHR, AR, SRD5A1
27adenoma13.3SRD5A1, FSHB, SHBG, CGA, GNRHR
28breast cancer13.3BRCA2, GNRHR, AR, SHBG, CYP19A1, SRD5A1
29impotence13.3SRD5A1, SHBG
30leydig cell tumor13.3CGA, CYP19A1, SRD5A1
31obesity13.3AR, SHBG, SRD5A1
32prostate cancer13.3GNRHR, AR, SRD5A1, SRD5A2
33prostate disease13.3SRD5A1, CYP19A1, AR
34prostatitis13.3SRD5A1
35wilms tumor13.3BRCA2, SOX9, SRY, SRD5A1
36penis agenesis13.3SRD5A2, SRD5A1, CGA, AR
37partial androgen insensitivity syndrome13.3AR, SHBG, CYP19A1, SRD5A1
38seminoma10.1
39freemartinism10.0
40penile disease10.0
41sexual disorder10.0
42vaginitis10.0
43palmoplantar hyperkeratosis and true hermaphroditism10.0
44premature ovarian failure10.0AMH
45testicular disease10.0SRY
46thyroiditis10.0CGA
47conduct disorder10.0CGA
48prostatic hypertrophy10.0AR
49hypoactive sexual desire disorder10.0SHBG
50insulin resistance10.0SHBG

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Clinical Features for Hermaphroditism

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Drugs & Therapeutics for Hermaphroditism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hermaphroditism

Search CenterWatch for Hermaphroditism

Genetic Tests for Hermaphroditism

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Anatomical Context for Hermaphroditism

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32MalaCards
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MalaCards organs/tissues related to Hermaphroditism:

32
Testes, Uterus, Testis, Kidney, Pituitary, Ovary, Cervix

Animal Models for Hermaphroditism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hermaphroditism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.2GNRHR, SOX9, CSNK1D, AR, RBFOX1, CGA
2MP:00053797.1AR, SOX9, GNRHR, AMH, BRCA2, CGA
3MP:00053896.9RSPO1, BRCA2, AMH, GNRHR, SOX9, AR

Publications for Hermaphroditism

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50PubMed
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Articles related to Hermaphroditism:

(show top 50)    (show all 431)
idTitleAuthorsYear
1
Surgical treatment of hermaphroditism: experience with 25 cases. (19806042)
2009
2
Evolutionary perspectives on hermaphroditism in fishes. (19684459)
2009
3
First colored illustration and detailed description of hermaphroditism by a Turkish surgeon, Serefeddin SabuncuoA9lu, in the 15th century. (18046159)
2007
4
A rare presentation of true hermaphroditism: an abnormal inguinoscrotal mass. (17984957)
2007
5
Hermaphroditism in 3 chimeric mice. (17317810)
2007
6
Same sexual system but variable sociobiology: evolution of protandric simultaneous hermaphroditism in Lysmata shrimps. (21672755)
2006
7
Testing three models on the adaptive significance of protandric simultaneous hermaphroditism in a marine shrimp. (17089968)
2006
8
Gonochorism vs. hermaphroditism: relationship between life history and fitness in three species of Ophryotrocha (Polychaeta: Dorvilleidae) with different forms of sexuality. (16903057)
2006
9
True hermaphroditism in a horned goat with 60XX/60XY chimerism. (10907580)
2000
10
True hermaphroditism: 10 years' experience. (11149399)
2000
11
Crossed ectopia of ovotestis in a case of true hermaphroditism. (8906684)
1996
12
True hermaphroditism and normal male genitalia: an unusual presentation. (7495134)
1995
13
True hermaphroditism: geographical distribution, clinical findings, chromosomes and gonadal histology. (8313919)
1994
14
Hermaphroditism in young mouse chimeras. (1298409)
1992
15
True hermaphroditism: a report of two cases. (2079477)
1990
16
True hermaphroditism: diagnosis and surgical treatment. (3402087)
1988
17
Lateral hermaphroditism and seminoma in a dog. (3793600)
1986
18
Ethical problems in family psychotherapy of patients with hermaphroditism. (3834263)
1985
19
True hermaphroditism. A review of 41 cases with observations on testicular histology and function. (4084741)
1985
20
True hermaphroditism with vaginomegaly: a cause of pseudo-urinary tract infection. (6620021)
1983
21
True hermaphroditism. Case report and some observations. (6890523)
1982
22
True hermaphroditism: etiology and phenotypic considerations. (365271)
1978
23
Simultaneous hermaphroditism; cost and benefit. (839809)
1977
24
Male hermaphroditism with bilateral testes, well-formed MA1llerian structures, and 45,X chromosome complement. (940632)
1976
25
A case of true hermaphroditism presenting as an undescended testicle. (4154009)
1974
26
The management of paediatric hermaphroditism. (4428286)
1974
27
True hermaphroditism. (5556712)
1971
28
Genetic and clinical studies in male hermaphroditism. (5763234)
1969
29
A possible correlation between chromosomal pattern and gonadal morphology in cases of mixed gonadal dysgenesis, XO-XX and XO-XY mosaicism, true hermaphrodites and XX males. (5649946)
1968
30
Hermaphroditism, sex chromosomal mosaicism and germ cell selection in allophenic mice. (5212491)
1968
31
Contribution to a theory of hermaphroditism. (6055374)
1967
32
MALE PSEUDO HERMAPHRODITISM. (14318105)
1965
33
The human Y chrosome and the etiology of true hermaphroditism with the report of a case with XX-XY sex chromosome mosaicism. (5889237)
1965
34
PATHOLOGIC AND CYTOGENETIC FINDINGS IN TRUE HERMAPHRODITISM; REPORT OF 6 CASES AND REVIEW OF 23 CASES FROM THE LITERATURE. (14268028)
1965
35
HERMAPHRODITISM WITH "ATYPICAL" OR "MIXED" GONADAL DYSGENESIS. RELATIONSHIP TO GONADAL NEOPLASM. (14124695)
1964
36
Female hermaphroditism without virilization. (13465085)
1957
37
A case of true hermaphroditism: a further report. (13460330)
1957
38
True hermaphroditism. (13439384)
1957
39
A case of true hermaphroditism. (13292092)
1955
40
Hermaphroditism: classification, diagnosis and treatment. (13274465)
1955
41
True hermaphroditism with report of a case. (13070316)
1953
42
A case of male pseudo-hermaphroditism. (13084835)
1953
43
A case of hermaphroditism in a carthorse. (18208215)
1949
44
A Study of the Beta 17 Ketosteroids in a Case of Pseudo-hermaphroditism Due to Adrenal Cortical Tumor. (17859267)
1948
45
Two cases of true hermaphroditism. (21005420)
1945
46
Pseudo-hermaphroditism. (19991637)
1938
47
HERMAPHRODITISM IN DENDRASTER. (17773221)
1929
48
HERMAPHRODITISM IN ARBACIA. (17755630)
1929
49
Case of Supposed Hermaphroditism. (19975258)
1911
50
Case of Hermaphroditism in a Common Frog (Rana temporaria). (17231850)
1890

Genetic Variations for Hermaphroditism

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Expression for genes affiliated with Hermaphroditism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hermaphroditism

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Pathways for genes affiliated with Hermaphroditism

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53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 55SinoBiological, 52R&D Systems
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Compounds for genes affiliated with Hermaphroditism

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44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Hermaphroditism according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9
2epitestosterone4410.3SHBG, CGA
3formestane4410.2CYP19A1, SHBG
4norgestimate44 1111.2AR, SHBG
5ment4410.2SHBG, CYP19A1
6ganirelix44 2811.1GNRHR, FSHB, CGA
7leuprolide44 59 28 1113.0CGA, GNRHR, AR
8dutasteride44 1111.0AR, SRD5A2, CYP19A1
9hydroxyflutamide44 2811.0AR, CGA, SHBG
10androstanedione44 11 2412.0CYP19A1, SRD5A2
11androstenediol4410.0AR, SHBG, CYP19A1
125alpha-androstane-3alpha,17beta-diol449.9CYP19A1, AR, SHBG
13exemestane49 44 59 1112.9AR, CYP19A1, SHBG
14Drostanolone119.9SHBG, AR, CYP19A1
1517-hydroxyprogesterone44 2410.9CGA, CYP19A1, SHBG
16cyproteroneacetate449.9SHBG, CYP19A1, AR
17levonorgestrel44 59 28 1112.9CYP19A1, AR, SHBG
18nafarelin44 59 28 1112.9GNRHR, CYP19A1, CGA
19buserelin44 28 1111.8CYP19A1, FSHB, CGA, GNRHR
20Methyltestosterone119.8CYP19A1, SHBG, AR
21goserelin44 28 1111.8CGA, SHBG, CYP19A1, GNRHR
22finasteride44 59 11 2412.8AR, SHBG, CYP19A1, SRD5A2
23clomiphene citrate449.7CGA, FSHB, SHBG, CYP19A1
24ketoconazole44 28 11 2412.7SHBG, CYP19A1, AR
253beta-hydroxysteroid449.7AR, CGA, CYP19A1, SRD5A2
2617beta-hydroxysteroid449.7SRD5A2, CYP19A1, CGA, AR
27progestins449.7CYP19A1, AR, SHBG
28flutamide44 59 1111.7CYP19A1, SHBG, CGA, AR
29dehydroepiandrosterone sulfate449.7AR, CGA, SHBG, CYP19A1
30danazol44 11 2411.7GNRHR, AR, SHBG, CYP19A1
31nandrolone44 2410.7CYP19A1, SHBG, AR
32letrozole44 49 59 1112.6SHBG, CGA, AR, CYP19A1
33progestin449.6CYP19A1, AR, SHBG, CGA
34leuprolide acetate449.6SHBG, FSHB, GNRHR, CGA, CYP19A1
35deoxyribonucleic acid449.6GNRHR, ZFY, FSHB, SRY, SRD5A2
36dhea449.5CYP19A1, SHBG, AR
37estrone44 28 11 2412.5SHBG, AR, CYP19A1
38anastrozole44 1110.5CYP19A1, SHBG, CGA
39androstenedione44 2410.5SHBG, CGA, AR, CYP19A1, SRD5A2
40diethylstilbestrol44 28 1111.5CYP19A1, CGA, SHBG, AR
41mifepristone44 59 28 1112.3CYP19A1, SHBG, AMH, CGA, AR
42vitamin d449.3AR, CGA, SHBG, SRD5A2, CYP19A1
43gnrh449.2CYP19A1, GNRHR, AR, CGA, SHBG, FSHB
44dihydrotestosterone44 28 11 2412.1CGA, SHBG, CYP19A1, GNRHR, SRD5A2, SRY
45ribonucleic acid448.9SRD5A2, CGA, GNRHR, SOX9, FSHB
46tamoxifen44 49 28 1111.8AR, SHBG, CGA, BRCA2, AMH, GNRHR
47estradiol44 11 2410.3GNRHR, SRY, BRCA2, AMH, SRD5A2, FSHB
48progesterone44 59 28 11 2412.2SHBG, WNT4, CYP19A1, SRD5A2, FSHB, BRCA2
49steroid448.2BRCA2, CYP19A1, SRD5A2, SRY, FSHB, SHBG
50testosterone44 59 11 2410.7WNT4, SOX9, AR, CGA, SHBG, CYP19A1

GO Terms for genes affiliated with Hermaphroditism

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16Gene Ontology
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Biological processes related to Hermaphroditism according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1sex determinationGO:00753010.4AMH
2androgen biosynthetic processGO:00670210.3SRD5A2, WNT4
3sex differentiationGO:00754810.2AMH, AR
4positive regulation of male gonad developmentGO:200002010.2SOX9, SRY
5renal vesicle inductionGO:07203410.2SOX9, WNT4
6tertiary branching involved in mammary gland duct morphogenesisGO:06074810.2AR, WNT4
7steroid metabolic processGO:00820210.2SRD5A2, CYP19A1
8prostate gland developmentGO:03085010.1SOX9, AR
9prostate gland growthGO:06073610.0CYP19A1, AR
10peptide hormone processingGO:01648610.0CGA, FSHB
11androgen metabolic processGO:00820910.0SRD5A2, CYP19A1
12positive regulation of canonical Wnt receptor signaling pathwayGO:0902639.9CSNK1E, CSNK1D, WNT4, RSPO1
13female gonad developmentGO:0085859.7BRCA2, WNT4
14male gonad developmentGO:0085849.5SRD5A2, SRY, WNT4, AR, SOX9
15cell-cell signalingGO:0072679.5SRD5A2, WNT4, CGA, AR, AMH
16spermatogenesisGO:0072839.3FSHB, AR, SOX9, BRCA2
17positive regulation of transcription, DNA-dependentGO:0458939.2BRCA2, SOX9, AR, WNT4, SRY
18positive regulation of cell migrationGO:0303359.2FSHB, RRAS2, CGA
19signal transductionGO:0071659.1SOX9, CSNK1E, CSNK1D, AR, CGA, FSHB

Molecular functions related to Hermaphroditism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00386510.3SRD5A2
2cholestenone 5-alpha-reductase activityGO:04775110.2SRD5A2
3hormone activityGO:0051799.8FSHB, CGA, AMH
4androgen bindingGO:0054979.6SHBG, AR

Products for genes affiliated with Hermaphroditism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hermaphroditism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet