MCID: HRM002
MIFTS: 37

Hermaphroditism malady

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Hermaphroditism

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Summaries for Hermaphroditism

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MalaCards based summary: Hermaphroditism is related to mixed gonadal dysgenesis and 46xx sex reversal 1. An important gene associated with Hermaphroditism is SRY (Sex Determining Region Y), and among its related pathways are Deactivation of the beta-catenin transactivating complex and Nongenotropic Androgen signaling. Affiliated tissues include testes, breast and testis, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Related Diseases for Hermaphroditism

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Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1mixed gonadal dysgenesis28.0NR0B1, SHBG, SOX9, SRY, WNT4
246xx sex reversal 111.7
3palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal11.5
446xy sex reversal 110.9
5pseudohermaphroditism10.5
6sideroblastic anemia pyridoxine-responsive autosomal recessive10.2AR, SRY
7gastrojejunal ulcer10.2AR, SRD5A2
8prolapse of lacrimal gland10.2AR, SRY
9gonadal dysgenesis10.1
10vaginal discharge10.1AR, SRD5A2
11dental pulp necrosis10.1SHBG, WNT4
12mongolian spot10.1AR, SRD5A2
13gonadoblastoma10.1
14dystonia-parkinsonism, x-linked10.1AR, SHBG
15spermatogenic failure, y-linked, 110.1SOX9, SRY
16botulism10.0AR, SHBG
1746,xx testicular disorder of sex development10.0
1848,xxxy syndrome10.0SOX9, SRY
19adult brainstem gliosarcoma10.0AR, SRY
20inguinal hernia10.0
21farmer's lung10.0SOX9, SRY
22glioblastoma classical subtype10.0AR, SHBG
23prostate adenocarcinoma10.0SOX9, SRY
24signet ring cell adenocarcinoma10.0SHBG, SRY
25abca1-related disorders10.0NR0B1, SRY, WNT4
26hypospadias10.0
27seminoma10.0
28hydronephrosis, congenital, with cleft palate, characteristic facies, hypotonia, and mental retardation10.0SOX9, SRY
29leech infestation9.9
30benign paroxysmal positional nystagmus9.9SHBG, SRY, WNT4
31alveolar soft-part sarcoma9.9SOX9, SRY
32gonadal dysgenesis, xy type, with associated anomalies9.9
3346 xy gonadal dysgenesis9.9
34multiple synostoses syndrome9.9SOX9, SRY
35alternating hemiplegia of childhood9.9NR0B1, SRY
36androgen insensitivity9.9
37klinefelter's syndrome9.9
38vaginitis9.9
39freemartinism9.9
40hypogonadism9.8AR, SHBG
41meacham syndrome9.8SOX9, SRY
42gaucher's disease9.8AR, SHBG, SRY
43myoclonic cerebellar dyssynergia9.7AR, SHBG, SRY
44candidiasis9.7AR, SHBG, SRY
45epilepsy, idiopathic generalized 119.7AR, SHBG, SRD5A2
46myelodysplastic syndrome9.7
47campomelic dysplasia9.7
48cryptorchidism9.7
49alopecia9.7
50hepatitis9.7

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Symptoms for Hermaphroditism

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Drugs & Therapeutics for Hermaphroditism

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Drugs for Hermaphroditism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DocetaxelApproved May 1996Phase 31880114977-28-5148124, 9877265
Synonyms:
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoate
(2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
01885_FLUKA
114977-28-5
4-(Acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
AC-383
AC1L3WHJ
ANX-514
BIND-014
C11231
CHEBI:4672
CHEMBL92
CID148124
D07866
DB01248
Docetaxel
Docetaxel (INN)
Docetaxel anhydrous
Docetaxel, Trihydrate
EmDOC
 
HMS2089K08
InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,5
MolPort-003-847-005
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-Boc-10-deacetyl taxol
NSC-628503
PSMA-targeted docetaxel nanoparticle
RP-56976
SDP-014
TXL
Taxotere
Taxotere (TN)
Taxotere(R)
XRP-6976L
docetaxel
docetaxel 114977-28-5
nchembio.188-comp8
nchembio.2007.34-comp7
nchembio.573-comp11
nchembio853-comp8
2
ramucirumabPhase 368947687-13-0
Synonyms:
IMC-1121B
 
IMC-3G3
ramucirumab
3
Epinephrine88651-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Ramucirumab (LY3009806) Plus Docetaxel in Participants With Urothelial CancerRecruitingNCT02426125Phase 3
2Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast CancerRecruitingNCT02474641Phase 3
3Qualitative Research on Women With Congenital Adrenal HyperplasiaCompletedNCT00559078
4Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in FranceCompletedNCT01211652
5National Survey on AsthmaCompletedNCT00770250
6Decision Support for Parents Receiving Information About Child's Rare DiseaseActive, not recruitingNCT01875640
7Reducing LGBTQ Adolescent SuicideEnrolling by invitationNCT02875535
8Gene Polymorphisms Influencing Steroid Synthesis and ActionWithdrawnNCT00485186

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

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Anatomical Context for Hermaphroditism

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MalaCards organs/tissues related to Hermaphroditism:

34
Testes, Breast, Testis, Uterus, Kidney, Pituitary, Ovary

Animal Models for Hermaphroditism or affiliated genes

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MGI Mouse Phenotypes related to Hermaphroditism:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.6AR, NR0B1, RSPO1, SOX9, SRD5A2, WNT4
2MP:00053897.5AR, NR0B1, RSPO1, SOX9, SRD5A2, WNT4

Publications for Hermaphroditism

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Articles related to Hermaphroditism:

(show top 50)    (show all 446)
idTitleAuthorsYear
1
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. (24742721)
2014
2
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. (23727055)
2013
3
Evolutionary transitions among dioecy, androdioecy and hermaphroditism in limnadiid clam shrimp (Branchiopoda: Spinicaudata). (19702888)
2009
4
Surgical treatment of hermaphroditism: experience with 25 cases. (19806042)
2009
5
Sry-negative XX true hermaphroditism in a roe deer. (18524504)
2009
6
Expression of R-ras oncogenes in the hermaphroditic fish Kryptolebias marmoratus, exposed to endocrine disrupting chemicals. (19000778)
2009
7
First colored illustration and detailed description of hermaphroditism by a Turkish surgeon, Serefeddin SabuncuoA9lu, in the 15th century. (18046159)
2007
8
Spontaneous ovulation in a true hermaphrodite with normal male phenotype and a rare 46,XX/47,XXY Klinefelter's mosaic karyotype. (17389808)
2007
9
True hermaphroditism in six female littermates after administration of synthetic androgens to a pregnant bitch. (16420323)
2006
10
Testing three models on the adaptive significance of protandric simultaneous hermaphroditism in a marine shrimp. (17089968)
2006
11
Invasive squamous cell carcinoma of the vagina in the setting of true hermaphroditism. (16171851)
2006
12
Screening for mutations in the WNT-4 gene in patients with 46,XX true hermaphroditism. (15589122)
2004
13
Reproductive uncertainty and the relative competitiveness of simultaneous hermaphroditism versus dioecy. (12858266)
2003
14
SRY gene transferred to the long arm of the X chromosome in a Y- positive XX true hermaphrodite. (10602113)
2000
15
True hermaphroditism in a horned goat with 60XX/60XY chimerism. (10907580)
2000
16
True hermaphroditism associated with microphthalmia. (10037254)
1999
17
Vaginal stone in a male patient with true hermaphroditism. (9488939)
1997
18
True hermaphroditism in a wild sheep: A clinical report. (16726991)
1991
19
Sexuality and hermaphroditism in fishes. I. Synchronous functional hermaphroditism in the serranid fish Serranus scriba L. (2341087)
1990
20
Case report of hermaphroditism in a rat. (3430932)
1987
21
Lateral hermaphroditism in a dog. (7107494)
1982
22
Gonadoblastoma and dysgerminoma in a true hermaphrodite with a 46,XX karyotype. (7246672)
1981
23
Hermaphroditism. (7398198)
1980
24
True hermaphroditism: etiology and phenotypic considerations. (365271)
1978
25
Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog. (675252)
1978
26
Familial true hermaphroditism. (757014)
1978
27
Report of a case of true hermaphroditism with karyotype 45,X/46,XX/46,X,mar/47,XX,mar. (563432)
1977
28
Letter: Gender identity and hermaphroditism. (1251201)
1976
29
Hermaphroditism associated with unusual gonadal finding in a mentally retarded child. (1236954)
1975
30
A case of true hermaphroditism presenting as an undescended testicle. (4154009)
1974
31
Hormonal and clinical aspects of hermaphroditism and the testicular feminizing syndrome in man. (4399064)
1970
32
True hermaphroditism unassociated with a common urogenital sinus. (5814093)
1969
33
True hermaphroditism with bilateral ovotestes. (5255117)
1969
34
Staff conference: University of Tennessee Hospital: hermaphroditism. (5934680)
1966
35
X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome. (4161595)
1966
36
HERMAPHRODITISM WITH "ATYPICAL" OR "MIXED" GONADAL DYSGENESIS. RELATIONSHIP TO GONADAL NEOPLASM. (14124695)
1964
37
"Mixed" gonadal dysgenesis: a variety of hermaphroditism. (13989874)
1963
38
Problems and management of hermaphroditism. (13894000)
1962
39
Female hermaphroditism without virilization. (13465085)
1957
40
Sex differences in human nuclei with particular reference to the Klinefelter syndrome, gonadal agenesis and other types of hermaphroditism. (13381386)
1956
41
Unilateral hermaphroditism in the mouse. (13249096)
1955
42
Hermaphroditism: classification, diagnosis, selection of sex and treatment. (13245335)
1955
43
TRUE HERMAPHRODITISM; a conference on the management of one patient. (13164000)
1954
44
Hermaphroditism. (13164736)
1954
45
True hermaphroditism. (14888497)
1952
46
A case of hermaphroditism. (14821342)
1951
47
True hermaphroditism. (20279555)
1946
48
TRUE HERMAPHRODITISM: REPORT OF A CASE WITH NECROPSY. (17856731)
1936
49
A Case of Malformation Assumed to be True Hermaphroditism. (19970086)
1933
50
Case of Hermaphroditism in a Common Frog (Rana temporaria). (17231850)
1890

Variations for Hermaphroditism

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Expression for genes affiliated with Hermaphroditism

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Search GEO for disease gene expression data for Hermaphroditism.

Pathways for genes affiliated with Hermaphroditism

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GO Terms for genes affiliated with Hermaphroditism

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Cellular components related to Hermaphroditism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear transcription factor complexGO:00447989.7SOX9, SRY

Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1renal vesicle inductionGO:007203410.3SOX9, WNT4
2cell fate commitmentGO:004516510.3SOX9, WNT4
3tertiary branching involved in mammary gland duct morphogenesisGO:006074810.2AR, WNT4
4epithelial to mesenchymal transitionGO:000183710.2SOX9, WNT4
5prostate gland developmentGO:003085010.2AR, SOX9
6androgen biosynthetic processGO:000670210.1SRD5A2, WNT4
7branching involved in ureteric bud morphogenesisGO:000165810.0SOX9, WNT4
8cellular response to transforming growth factor beta stimulusGO:007156010.0SOX9, WNT4
9positive regulation of male gonad developmentGO:200002010.0SOX9, SRY
10negative regulation of epithelial cell proliferationGO:00506809.9AR, SOX9
11adrenal gland developmentGO:00303259.9NR0B1, WNT4
12negative regulation of cell differentiationGO:00455969.9NR0B1, WNT4
13hypothalamus developmentGO:00218549.8NR0B1, SRD5A2
14intracellular receptor signaling pathwayGO:00305229.8AR, NR0B1
15steroid biosynthetic processGO:00066949.8NR0B1, SRD5A2
16Leydig cell differentiationGO:00333279.7AR, NR0B1
17Sertoli cell differentiationGO:00600089.6NR0B1, SOX9
18sex differentiationGO:00075489.5AR, WNT4
19male sex determinationGO:00302389.2NR0B1, SOX9, SRY
20positive regulation of transcription, DNA-templatedGO:00458939.1AR, SOX9, SRY, WNT4
21spermatogenesisGO:00072838.9AR, NR0B1, SOX9
22cell differentiationGO:00301548.5NR0B1, SOX9, SRD5A2, SRY, WNT4
23male gonad developmentGO:00085847.9AR, NR0B1, SOX9, SRD5A2, SRY, WNT4

Molecular functions related to Hermaphroditism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:000370510.0SOX9, SRY
2RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:00048799.8AR, NR0B1
3androgen bindingGO:00054979.6AR, SHBG
4steroid bindingGO:00054969.0AR, SHBG
5transcription factor bindingGO:00081349.0AR, NR0B1, SRY

Sources for Hermaphroditism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet