MCID: HRM002
MIFTS: 49

Hermaphroditism malady

Reproductive diseases, Endocrine diseases categories

Summaries for Hermaphroditism

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66Wikipedia, 34MalaCards
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Wikipedia:66 In biology, a hermaphrodite is an organism that has reproductive organs normally associated with both... more...

MalaCards: Hermaphroditism is related to gonadoblastoma and 46xx sex reversal 1. An important gene associated with Hermaphroditism is SRY (sex determining region Y), and among its related pathways are Regulation of Androgen receptor activity and Steroid hormone biosynthesis. The compounds 7a,12a-Dihydroxy-5a-cholestan-3-one and 7a,12a-Dihydroxy-cholestene-3-one have been mentioned in the context of this disorder. Affiliated tissues include testes, uterus and kidney, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Aliases & Classifications for Hermaphroditism

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9Disease Ontology, 11DISEASES, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 26ICD10
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Related Diseases for Hermaphroditism

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18GeneCards, 19GeneDecks
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Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1gonadoblastoma30.5ZFY, SRY
246xx sex reversal 130.4SRD5A1, SRY
3mixed gonadal dysgenesis30.4SRY, SRD5A1
4dysgerminoma30.3CGA, SRY
5pseudohermaphroditism30.2AMH, SRY, SRD5A2, AR
6hypospadias30.1AR, CGA, SRD5A2, SRD5A1, SRY
7campomelic dysplasia30.1SRY
8klinefelter's syndrome30.0SHBG, SRD5A1, CGA, AR
9amenorrhea29.9SRY, AMH, SHBG
10alopecia29.9AR, SHBG
11androgen insensitivity syndrome29.9AR, CGA, SRD5A2, SRD5A1, SRY, SHBG
12male infertility29.8AR, SHBG
13infertility29.7AR, CGA, SRY, AMH, SHBG
14cryptorchidism29.6SRD5A1, SRY, AMH, SHBG, CGA, AR
15gynecomastia29.6SHBG, AR, CGA, SRD5A2, SRD5A1, SRY
16gonadal dysgenesis10.4
17seminoma10.2
18testicular disease10.1SRY
19turner syndrome10.1ZFY
20freemartinism10.1
21penile disease10.1
22palmoplantar hyperkeratosis and true hermaphroditism10.1
2346,xy disorder of sex development and 46,xy complete gonadal dysgenesis10.1SRY, WNT4
24luteoma10.1SRY, CGA
25prostatic hypertrophy10.1AR
26congenital adrenal hyperplasia10.0SRY, SRD5A1
27abrikosov's tumor10.0CGA, AMH
28varicocele10.0CGA, SHBG
29ovarian disease10.0CGA, SHBG
30impotence10.0SHBG, SRD5A1
31short stature10.0SRY, SHBG
32leydig cell tumor10.0CGA, SRD5A1
33hypopituitarism10.0SHBG, CGA
34hypothyroidism10.0SHBG, CGA
35prostate disease10.0SRD5A1, AR
36germ cell cancer10.0CGA, AR
37complete androgen insensitivity syndrome10.0SHBG, AR
38testicular cancer10.0SHBG, CGA
39precocious puberty10.0SHBG, AMH, CGA
40hyperprolactinemia10.0SHBG, SRD5A1, CGA
41hyperthyroidism10.0CGA, SRD5A1, SHBG
42partial androgen insensitivity syndrome9.9SHBG, SRD5A1, AR
43hypogonadism9.9AR, CGA, SHBG
44anovulation9.9SHBG, AMH, SRD5A1, CGA
45microphthalmia9.9
46non-gestational ovarian choriocarcinoma9.9
47gestational ovarian choriocarcinoma9.9
48mutism9.9
49leech infestation9.9
50sertoli cell tumor9.9

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Symptoms for Hermaphroditism

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Drugs & Therapeutics for Hermaphroditism

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hermaphroditism

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Genetic Tests for Hermaphroditism

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Anatomical Context for Hermaphroditism

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34MalaCards
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MalaCards organs/tissues related to Hermaphroditism:

34
Testes, Uterus, Kidney, Testis, Pituitary, Ovary, Cervix

Animal Models for Hermaphroditism or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hermaphroditism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.1AMH, SRY, SRD5A1, SRD5A2, WNT4, CGA
2MP:00053796.8AR, RSPO1, AMH, SRY, SRD5A1, SRD5A2

Publications for Hermaphroditism

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53PubMed
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Articles related to Hermaphroditism:

(show top 50)    (show all 426)
idTitleAuthorsYear
1
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. (23727055)
2013
2
Evolutionary transitions among dioecy, androdioecy and hermaphroditism in limnadiid clam shrimp (Branchiopoda: Spinicaudata). (19702888)
2009
3
Surgical treatment of hermaphroditism: experience with 25 cases. (19806042)
2009
4
Sry-negative XX true hermaphroditism in a roe deer. (18524504)
2009
5
Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation. (18085567)
2008
6
First colored illustration and detailed description of hermaphroditism by a Turkish surgeon, Serefeddin SabuncuoA9lu, in the 15th century. (18046159)
2007
7
Hermaphroditism: What's not to like? (17184795)
2007
8
True hermaphroditism with characteristics of Klinefelter's syndrome: a rare presentation. (16042329)
2005
9
Screening for mutations in the WNT-4 gene in patients with 46,XX true hermaphroditism. (15589122)
2004
10
An unusal case of hermaphroditism--a 46,XX/69,XXY chimera. (15270409)
2004
11
Bipolar hermaphroditism of somatic cell as the basis of its being and becoming: celldom appreciated. (12432206)
2002
12
Management of the African child with true hermaphroditism. (11172444)
2001
13
SRY gene transferred to the long arm of the X chromosome in a Y- positive XX true hermaphrodite. (10602113)
2000
14
An unusual case of delusional misidentification: 'delusional hermaphroditism'. (10364732)
1999
15
Vaginal stone in a male patient with true hermaphroditism. (9488939)
1997
16
True hermaphroditism in a wild sheep: A clinical report. (16726991)
1991
17
Sexuality and hermaphroditism in fishes. I. Synchronous functional hermaphroditism in the serranid fish Serranus scriba L. (2341087)
1990
18
True hermaphroditism: a new case with complex mosaicism. (2222927)
1990
19
Gender dysphoria in a child with true hermaphroditism. (3676994)
1987
20
Is true hermaphroditism a primary germ cell disorder? (3601818)
1987
21
Nephroblastoma in an ovotestis of a true hermaphrodite: a case report. (3033335)
1987
22
Plasma androgens during the luteal phase in a case of true hermaphroditism with bilateral ovotestis. (3159938)
1985
23
Whistling maids and crowing hens--hermaphroditism in folklore and biology. (7290904)
1981
24
Hermaphroditism. (7398198)
1980
25
Clinical, cytogenetical, histological, immunological and hormonal studies in a case of true hermaphroditism. (7428182)
1980
26
True hermaphroditism: a clinical description and a proposed function for the long arm of the Y chromosome. (671194)
1978
27
True hermaphroditism: etiology and phenotypic considerations. (365271)
1978
28
Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog. (675252)
1978
29
Report of a case of true hermaphroditism with karyotype 45,X/46,XX/46,X,mar/47,XX,mar. (563432)
1977
30
Gonadoblastoma in a true hermaphrodite with a 46,XX karyotype. (1250564)
1976
31
A case of true hermaphroditism presenting as an undescended testicle. (4154009)
1974
32
True hermaphroditism with XX-XY mosaicism: report of a case. (4737577)
1973
33
High incidence of true hermaphroditism in the early human embryos. (5163617)
1971
34
A possible correlation between chromosomal pattern and gonadal morphology in cases of mixed gonadal dysgenesis, XO-XX and XO-XY mosaicism, true hermaphrodites and XX males. (5649946)
1968
35
Staff conference: University of Tennessee Hospital: hermaphroditism. (5934680)
1966
36
X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome. (4161595)
1966
37
"Mixed" gonadal dysgenesis: a variety of hermaphroditism. (13989874)
1963
38
True hermaphroditism: including a case with chromosome analysis. (14024009)
1962
39
Problems and management of hermaphroditism. (13894000)
1962
40
A case of true hermaphroditism. (13753582)
1960
41
Sex differences in human nuclei with particular reference to the Klinefelter syndrome, gonadal agenesis and other types of hermaphroditism. (13381386)
1956
42
Unilateral hermaphroditism in the mouse. (13249096)
1955
43
Roentgenological differential diagnosis of simple hypospadia from hypospadia in hermaphroditism]. (13083763)
1953
44
True hermaphroditism. (14888497)
1952
45
A case of hermaphroditism. (14821342)
1951
46
Hermaphroditism and its treatment. (15423773)
1950
47
True hermaphroditism. (20279555)
1946
48
TRUE HERMAPHRODITISM: REPORT OF A CASE WITH NECROPSY. (17856731)
1936
49
Case of Supposed Hermaphroditism. (19975258)
1911
50
Case of Hermaphroditism in a Common Frog (Rana temporaria). (17231850)
1890

Variations for Hermaphroditism

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Expression for genes affiliated with Hermaphroditism

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hermaphroditism

Search GEO for disease gene expression data for Hermaphroditism.

Pathways for genes affiliated with Hermaphroditism

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51PathCards, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 56Reactome, 54QIAGEN
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Pathways related to Hermaphroditism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SRY, AR
2
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism39
9.5SRD5A2, SRD5A1
3
Show member pathways
estradiol biosynthesis II39
androgen biosynthesis39
estradiol biosynthesis I39
progesterone biosynthesis39
9.5SRD5A2, SRD5A1
49.5SRD5A2, SRD5A1
59.4AR, CGA
69.3AR, SHBG
7
Show member pathways
9.1SRD5A1, SRD5A2, CGA
8
Show member pathways
9.0SHBG, SRY, AR
9
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
8.6AR, WNT4, SRD5A2, SRD5A1

Compounds for genes affiliated with Hermaphroditism

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25HMDB, 62Tocris Bioscience, 46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB
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Compounds related to Hermaphroditism according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
17a,12a-Dihydroxy-5a-cholestan-3-one259.9SRD5A2, SRD5A1
27a,12a-Dihydroxy-cholestene-3-one259.8SRD5A1, SRD5A2
3es 936629.8SRD5A1, SRD5A2
4boldenone46 1210.7AR, SRD5A1
5formestane469.6SHBG, SRD5A1
6enterolactone469.6SHBG, SRD5A1
7pygeum469.6SRD5A1, AR
8ment469.5SHBG, SRD5A1
9epitestosterone469.4SHBG, SRD5A1, CGA
10chlormadinone acetate469.4SHBG, AR
11goserelin46 30 1211.4CGA, SRD5A1, SHBG
12dutasteride46 1210.3SRD5A1, SRD5A2, AR
13fluoxymesterone46 1210.3SHBG, AR
14oxandrolone46 1210.3AR, SHBG
1517-hydroxyprogesterone46 2510.3CGA, SRD5A1, SHBG
16leuprolide46 62 30 1212.3SRD5A1, CGA, AR
17phenytoin46 52 30 1212.2SHBG, SRD5A1, CGA
18letrozole46 52 62 1212.2AR, CGA, SHBG
19stanozolol469.2SHBG, AR
20norgestimate46 1210.2SHBG, SRD5A1, AR
21androstenediol469.2AR, SRD5A1, SHBG
225alpha-androstane-3alpha,17beta-diol469.2SHBG, SRD5A1, AR
23deoxyribonucleic acid469.2SRD5A2, SRY, ZFY
24diethylstilbestrol46 30 1211.2SHBG, CGA, AR
25exemestane46 52 62 1212.2AR, SRD5A1, SHBG
26cyproteroneacetate469.2SHBG, SRD5A1, AR
27levonorgestrel46 62 30 1212.2SHBG, SRD5A1, AR
28spironolactone46 62 30 52 1213.2SHBG, SRD5A1, AR
29ketoconazole46 30 25 1212.1AR, SRD5A1, SHBG
30progestins469.1AR, SRD5A1, SHBG
31r1881469.0SHBG, AR
32dhea469.0AR, SRD5A1, SHBG
333beta-hydroxysteroid468.9SRD5A1, SRD5A2, CGA, AR
34mifepristone46 30 62 1211.9SHBG, AMH, CGA, AR
3517beta-hydroxysteroid468.9SRD5A1, SRD5A2, CGA, AR
36finasteride46 62 25 1211.8AR, SRD5A2, SRD5A1, SHBG
37hydroxyflutamide46 309.8SHBG, SRD5A1, CGA, AR
38flutamide46 62 1210.8AR, CGA, SRD5A1, SHBG
39dehydroepiandrosterone sulfate468.8SHBG, SRD5A1, CGA, AR
40progestin468.8SHBG, SRD5A1, CGA, AR
41tamoxifen46 52 30 1211.7AR, CGA, AMH, SHBG
42gnrh468.7SHBG, SRD5A1, CGA, AR
43androstenedione46 259.4SHBG, SRD5A1, SRD5A2, CGA, AR
44vitamin d468.3SHBG, SRD5A1, SRD5A2, CGA, AR
45dihydrotestosterone46 30 25 1211.1SHBG, SRY, SRD5A1, SRD5A2, CGA, AR
46steroid468.0SHBG, SRY, SRD5A1, SRD5A2, CGA, AR
47estrogen467.9SHBG, AMH, SRD5A1, SRD5A2, CGA, AR
48estradiol46 25 129.7SHBG, AMH, SRY, SRD5A1, SRD5A2, CGA
49progesterone46 30 62 25 1211.7SHBG, AMH, SRD5A1, SRD5A2, WNT4, CGA
50testosterone46 62 25 1210.4AR, SHBG, AMH, SRY, SRD5A1, SRD5A2

GO Terms for genes affiliated with Hermaphroditism

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17Gene Ontology
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Biological processes related to Hermaphroditism according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of canonical Wnt signaling pathwayGO:0902639.8RSPO1, WNT4
2canonical Wnt signaling pathwayGO:0600709.7WNT4, RSPO1
3sex determinationGO:0075309.7SRD5A1, AMH
4steroid metabolic processGO:0082029.6SRD5A2, SRD5A1
5male gonad developmentGO:0085849.4WNT4, SRD5A2
6androgen biosynthetic processGO:0067029.4SRD5A1, SRD5A2, WNT4
7positive regulation of transcription, DNA-templatedGO:0458939.2AR, WNT4, SRY
8cell differentiationGO:0301549.0AMH, SRY, SRD5A1, SRD5A2
9sex differentiationGO:0075488.9AR, SRD5A1, SRY, AMH
10cell-cell signalingGO:0072678.8AR, CGA, SRD5A2, AMH

Molecular functions related to Hermaphroditism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:0038659.5SRD5A2, SRD5A1
2cholestenone 5-alpha-reductase activityGO:0477519.4SRD5A2, SRD5A1
3receptor bindingGO:0051029.2AR, AMH, RSPO1
4androgen bindingGO:0054979.0AR, SHBG

Products for genes affiliated with Hermaphroditism

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Sources for Hermaphroditism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet