MCID: HRM002
MIFTS: 38

Hermaphroditism malady

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Hermaphroditism

Summaries for Hermaphroditism

MalaCards based summary : Hermaphroditism is related to 46xx sex reversal 1 and palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal. An important gene associated with Hermaphroditism is SRY (Sex Determining Region Y), and among its related pathways/superpathways are Signaling by Wnt and Regulation of Androgen receptor activity. The drugs Epinephrine and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, uterus and testis, and related phenotypes are endocrine/exocrine gland and reproductive system

Related Diseases for Hermaphroditism

Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
id Related Disease Score Top Affiliating Genes
1 46xx sex reversal 1 11.8
2 palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal 11.4
3 pseudohermaphroditism 11.3
4 leech infestation 10.8
5 46xy sex reversal 1 10.8
6 8p23.1 duplication syndrome 10.2 SOX9 SRY
7 spermatogenic failure, y-linked, 1 10.2 SOX9 SRY
8 brucella melitensis brucellosis 10.2 SOX9 SRY
9 abl1 kd-related altered drug metabolism 10.2 SRY WNT4
10 autosomal dominant optic atrophy and late-onset deafness 10.2 SOX9 SRY
11 orofaciodigital syndrome x 10.2 SOX9 SRY
12 alveolar soft-part sarcoma 10.2 SOX9 SRY
13 cone dystrophy 10.2 SOX9 SRY
14 borderline personality disorder 10.1 AR SRD5A2
15 deafness, autosomal recessive 51 10.1 SOX9 SRY
16 esophagus sarcoma 10.1 AR SRY
17 third ventricle chordoid glioma 10.1 AR SRD5A2
18 dystonia-parkinsonism, x-linked 10.1 AR SHBG
19 ulceroglandular tularemia 10.0 AR SHBG
20 antisynthetase syndrome 10.0 CGA SRY
21 46 xx gonadal dysgenesis 10.0 SOX9 SRY WNT4
22 skin hemangioma 10.0 AR SRD5A2
23 glioblastoma mesenchymal subtype 10.0 AR SHBG
24 adenosquamous cell lung carcinoma 10.0 AR SRY
25 gonadal dysgenesis 10.0
26 exocervical carcinoma 10.0 AR SHBG
27 malignant teratocarcinosarcoma 10.0 AR CGA
28 acute gonococcal salpingitis 10.0 SHBG SRY WNT4
29 gonadoblastoma 9.9
30 sphingolipidosis 9.9 AR SHBG SRY
31 capillary lymphangioma 9.9 AR SHBG SRY
32 leukoencephalopathy with ataxia 9.9 AR SHBG SRD5A2
33 avoidant personality disorder 9.9 AR SHBG SRY
34 gaucher's disease 9.9 AR SHBG
35 46,xx testicular disorder of sex development 9.9
36 trachea carcinoma in situ 9.9 CGA SHBG
37 splenic disease 9.9 CGA SOX9 SRY
38 inguinal hernia 9.9
39 benign essential hypertension 9.9 AR SOX9 SRD5A2 SRY
40 periodic fever, aphthous stomatitis, pharyngitis and adenitis 9.8 AR CGA SRD5A2
41 epidural spinal canal meningioma 9.8 CGA SHBG
42 hypospadias 9.8
43 mixed gonadal dysgenesis 9.8
44 seminoma 9.8
45 pelvic muscle wasting 9.8 SHBG WNT4
46 farmer's lung 9.8 SHBG SOX9 SRY WNT4
47 gonadal dysgenesis, xy type, with associated anomalies 9.8
48 46 xy gonadal dysgenesis 9.8
49 retroperitoneal sarcoma 9.8 CGA SHBG
50 breast myoepithelial neoplasm 9.7 AR CGA SHBG

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to Hermaphroditism

Symptoms & Phenotypes for Hermaphroditism

MGI Mouse Phenotypes related to Hermaphroditism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 AR CGA RSPO1 SOX9 SRD5A2 WNT4
2 reproductive system MP:0005389 9.1 AR CGA RSPO1 SOX9 SRD5A2 WNT4

Drugs & Therapeutics for Hermaphroditism

Drugs for Hermaphroditism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2 Adrenergic Agents
3 Adrenergic Agonists
4 Adrenergic alpha-Agonists
5 Adrenergic beta-Agonists
6 Anti-Asthmatic Agents
7 Autonomic Agents
8 Bronchodilator Agents
9 Epinephryl borate
10 Mydriatics
11 Neurotransmitter Agents
12 Peripheral Nervous System Agents
13 Psychotropic Drugs
14 Racepinephrine
15 Respiratory System Agents
16 Vasoconstrictor Agents
17 Analgesics
18 Analgesics, Non-Narcotic
19 Anti-Inflammatory Agents
20 Anti-Inflammatory Agents, Non-Steroidal
21 Antirheumatic Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast Cancer Recruiting NCT02474641 Phase 3
2 Qualitative Research on Women With Congenital Adrenal Hyperplasia Completed NCT00559078
3 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
4 National Survey on Asthma Completed NCT00770250
5 Resilience Against Depression Disparities (Also Known as Resilience Education to Reduce Depression Disparities) Recruiting NCT02986126
6 Decision Support for Parents Receiving Information About Child's Rare Disease Active, not recruiting NCT01875640
7 Reducing LGBTQ Adolescent Suicide Enrolling by invitation NCT02875535
8 Gene Polymorphisms Influencing Steroid Synthesis and Action Withdrawn NCT00485186

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

Anatomical Context for Hermaphroditism

MalaCards organs/tissues related to Hermaphroditism:

39
Testes, Uterus, Testis, Kidney, Pituitary, Cervix, Ovary

Publications for Hermaphroditism

Articles related to Hermaphroditism:

(show top 50) (show all 446)
id Title Authors Year
1
Rediscovering hermaphroditism in Grammatidae with the description of the testicular gland in Brazilian Basslet Gramma brasiliensis. ( 27097082 )
2016
2
Hermaphroditism in Leonardo da Vinci's Drawing "Angel in the Flesh" (1513-1515). ( 26980592 )
2016
3
Hermaphroditism in a Roman fresco from Herculaneum (first century A.D.), National Archaeological Museum, Naples, Italy. ( 27412518 )
2016
4
Persistence of Reduced Androgenic Glands after Protandric Sex Change Suggests a Basis for Simultaneous Hermaphroditism in a Caridean Shrimp. ( 27132133 )
2016
5
"The persistence of memory"-Hermaphroditism in nematodes. ( 27291983 )
2016
6
Gonad development and hermaphroditism in the ascidian Botryllus schlosseri. ( 27228546 )
2016
7
A case of true hermaphroditism presenting as a testicular tumour. ( 25774314 )
2015
8
The Basement Membrane and the Sex Establishment in the Juvenile Hermaphroditism During Gonadal Differentiation of the Gymnocorymbus ternetzi (Teleostei: Characiformes: Characidae). ( 26386207 )
2015
9
Selfish male-determining element favors the transition from hermaphroditism to androdioecy. ( 25643740 )
2015
10
Direct reciprocity stabilizes simultaneous hermaphroditism at high mating rates: A model of sex allocation with egg trading. ( 26150086 )
2015
11
7- OVOTESTICULAR DSD (TRUE HERMAPHRODITISM). ( 25105460 )
2014
12
Embryology and adult urology - Not always mutually exclusive: A case report on true hermaphroditism at an adult urology clinic. ( 25295140 )
2014
13
Evidence of Hermaphroditism and Sex Ratio Distortion in the Fungal Feeding Nematode Bursaphelenchus okinawaensis. ( 25122669 )
2014
14
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. ( 24742721 )
2014
15
A small XY chromosomal region explains sex determination in wild dioecious V. vinifera and the reversal to hermaphroditism in domesticated grapevines. ( 25179565 )
2014
16
Histological and genetic characterization of true hermaphroditism in Korean pigs. ( 23018792 )
2013
17
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. ( 23727055 )
2013
18
Linking micromorphism, brooding, and hermaphroditism in brachiopods: insights from Caribbean Argyrotheca (Brachiopoda). ( 23400897 )
2013
19
Reproductive cycle and strategy of Anodonta anatina (L., 1758): notes on hermaphroditism. ( 23776103 )
2013
20
Phylogenetic perspectives on the evolution of functional hermaphroditism in teleost fishes. ( 23817661 )
2013
21
Female pseudo-hermaphroditism with cloacal malformation and related anomalies in a dog. ( 23543931 )
2012
22
The role of androdioecy and gynodioecy in mediating evolutionary transitions between dioecy and hermaphroditism in the animalia. ( 23206127 )
2012
23
True hermaphrodite presenting as primary amenorrhea. ( 22837933 )
2012
24
Sequential hermaphroditism and personality in a clonal vertebrate: the mangrove killifish. ( 22365923 )
2012
25
Iatrogenic androgenetic alopecia in a male phenotype 46XX true hermaphrodite. ( 21729028 )
2012
26
Back-and-forth hermaphroditism: phylogenetic context of reproductive system evolution in subdioecious Daphne laureola. ( 21644956 )
2011
27
Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite. ( 22070612 )
2011
28
True hermaphroditism: first evidence of an ovotestis in a cetacean species. ( 20708743 )
2011
29
A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat. ( 20861501 )
2011
30
The evolution of hermaphroditism by an infectious male-derived cell lineage: an inclusive-fitness analysis. ( 21750383 )
2011
31
Molecular mechanisms underlying sex change in hermaphroditic groupers. ( 20467860 )
2010
32
Insights into species divergence and the evolution of hermaphroditism from fertile interspecies hybrids of Caenorhabditis nematodes. ( 20823339 )
2010
33
Hermaphroditism among dioecious Tagelus plebeius (Lightfoot, 1786) (Mollusca, Psammobiidae) and Iphigenia brasiliana (Lamarck, 1818) (Mollusca, Donacidae) on the Cachoeira River estuary, IlhAcus, Bahia, Brazil. ( 20231968 )
2010
34
Evidence for hermaphroditism in the Squalius alburnoides allopolyploid fish complex. ( 20559019 )
2010
35
A fungal parasite regulates a putative female-suppressor gene homologous to maize tasselseed2 and causes induced hermaphroditism in male buffalograss. ( 20121446 )
2010
36
Expression of R-ras oncogenes in the hermaphroditic fish Kryptolebias marmoratus, exposed to endocrine disrupting chemicals. ( 19000778 )
2009
37
Chimerism in black southern African patients with true hermaphroditism 46,XX/47XY,+21 and 46,XX/46,XY. ( 19154517 )
2009
38
Surgical treatment of hermaphroditism: experience with 25 cases. ( 19806042 )
2009
39
Evolutionary transitions among dioecy, androdioecy and hermaphroditism in limnadiid clam shrimp (Branchiopoda: Spinicaudata). ( 19702888 )
2009
40
Accessory male investment can undermine the evolutionary stability of simultaneous hermaphroditism. ( 19605385 )
2009
41
Pure ovarian choriocarinoma mimicking ectopic pregnancy in true hermaphroditism. ( 19363709 )
2009
42
Molecular evolution in Panagrolaimus nematodes: origins of parthenogenesis, hermaphroditism and the Antarctic species P. davidi. ( 19149894 )
2009
43
Ovotesticular disorder of sexual development (true hermaphroditism). ( 18822450 )
2009
44
Expression of gonadotropin alpha, follicle-stimulating hormone beta, and luteinizing hormone beta genes of the hermaphroditic fish Kryptolebias marmoratus exposed to octylphenol, 17beta estradiol, and tamoxifen. ( 19456401 )
2009
45
Sry-negative XX true hermaphroditism in a roe deer. ( 18524504 )
2009
46
Evolutionary perspectives on hermaphroditism in fishes. ( 19684459 )
2009
47
Diagnosis of true hermaphroditism in a fetus with acampomelic campomelic dysplasia. ( 19253311 )
2009
48
Bilateral gonadoblastomas with a left sided dysgerminoma in a true hermaphrodite (disorder of sexual differentiation) with 46, XY karyotype. ( 18846912 )
2008
49
Gonadotropin-releasing hormone receptor (GnRHR) gene expression is differently modulated in gender types of the hermaphroditic fish Kryptolebias marmoratus by endocrine disrupting chemicals. ( 18280221 )
2008
50
Salmacisia, a new genus of Tilletiales: reclassification of Tilletia buchloA<ana causing induced hermaphroditism in buffalograss. ( 18488354 )
2008

Variations for Hermaphroditism

Expression for Hermaphroditism

Search GEO for disease gene expression data for Hermaphroditism.

Pathways for Hermaphroditism

GO Terms for Hermaphroditism

Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.83 SOX9 SRD5A2 SRY WNT4
2 positive regulation of transcription, DNA-templated GO:0045893 9.78 AR SOX9 SRY WNT4
3 regulation of transcription from RNA polymerase II promoter GO:0006357 9.76 AR CGA SOX9 SRY
4 cell-cell signaling GO:0007267 9.71 AR CGA SRD5A2
5 negative regulation of epithelial cell proliferation GO:0050680 9.57 AR SOX9
6 cellular response to transforming growth factor beta stimulus GO:0071560 9.56 SOX9 WNT4
7 cell fate commitment GO:0045165 9.55 SOX9 WNT4
8 branching involved in ureteric bud morphogenesis GO:0001658 9.51 SOX9 WNT4
9 epithelial to mesenchymal transition GO:0001837 9.49 SOX9 WNT4
10 male sex determination GO:0030238 9.43 SOX9 SRY
11 androgen biosynthetic process GO:0006702 9.4 SRD5A2 WNT4
12 prostate gland development GO:0030850 9.37 AR SOX9
13 positive regulation of male gonad development GO:2000020 9.32 SOX9 SRY
14 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.26 AR WNT4
15 male gonad development GO:0008584 9.26 AR SOX9 SRD5A2 WNT4
16 renal vesicle induction GO:0072034 9.16 SOX9 WNT4
17 sex differentiation GO:0007548 8.92 AR SRD5A2 SRY WNT4

Molecular functions related to Hermaphroditism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.43 AR RSPO1 WNT4
2 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.16 SOX9 SRY
3 steroid binding GO:0005496 8.96 AR SHBG
4 androgen binding GO:0005497 8.62 AR SHBG

Sources for Hermaphroditism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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