Hermaphroditism malady

Wikipedia: In biology, a hermaphrodite is an organism that has reproductive organs normally associated with both...⁴⁴ more...

MalaCards: Hermaphroditism, also known as hermaphroditism (disorder), is related to disorders of sex development and gonadal dysgenesis. An important gene associated with Hermaphroditism is SRY (sex determining region Y), and among its related pathways are Melanogenesis and Tight junction. The compounds (r)-(+)-blebbistatin and (s)-(-)-blebbistatin have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and no phenotypic analysis.

Aliases & Descriptions:

hermaphroditism 6 8 43 hermaphroditism (disorder) 6

Diseases related to hermaphroditism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 141)

id	Related Disease	Score	Top Affiliating Genes
1	disorders of sex development	31.2	AR, CYP21A2, SRD5A1, SRD5A2, SRY, WNT4
2	gonadal dysgenesis	29.3	ZFY, DAZ4, CYP21A2, SRD5A1, SRY, SHBG
3	pseudohermaphroditism	28.7	ZFY, AR, CYP17A1, CYP19A1, CYP21A2, SRD5A1
4	androgen insensitivity syndrome	28.4	CGA, AR, CYP19A1, SRD5A1, SRD5A2, SRY
5	cryptorchidism, idiopathic	14.2	DAZ1, DAZ2, DAZ3, DAZ4
6	distal arthrogryposis	14.2	MYH1, TNNT1, TNNT3, CPNE8, MYH2, MYH3
7	myocarditis	14.0	MYH1, MYH7B, TNNT2, AGTR1, MYH13, MYH15
8	basal cell carcinoma	14.0	FOXP3, HSPB1, GLI1, GLI2, GLI3, CYP1A1
9	y chromosome infertility	14.0	CGA, FSHB, AR, GNRHR, DAZ1, DAZ4
10	46, xy disorders of sex development	14.0	AR, SRD5A1, SRD5A2, SRY, WNT4
11	oligospermia	14.0	AR, GNRHR, DAZ1, DAZ2, DAZ4, SRD5A2
12	azoospermia	13.9	BRCA2, ZFY, CGA, FSHB, CDC25A, AR
13	mixed gonadal dysgenesis	13.9	CYP21A2, SRD5A1, SRY
14	cryptorchidism	13.9	CGA, AR, GNRHR, DAZ1, DAZ2, DAZ3
15	functioning pituitary adenoma	13.9	CGA, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5
16	familial hypertrophic cardiomyopathy	13.9	CALR3, CALR, TNNT1, TNNT2, AGTR1, MYH6
17	clubfoot	13.8	MYH1, GLI3, TNNT3, CYP1A1, WNT7A, MYH2
18	personality disorder	13.8	HTR1A, HTR1B, HTR1D, TPH1, TPH2, RXFP3
19	prolactinoma	13.7	CGA, GNRHR, SSTR1, SSTR2, SSTR3, SSTR4
20	oncogenic osteomalacia	13.7	SSTR1, SSTR2, SSTR3, SSTR5
21	familial restrictive cardiomyopathy	13.7	MAPK8, TNNT1, TNNT2, MYH7, MYL2
22	borderline personality disorder	13.6	HTR1A, HTR1B, HTR1D, TPH1, TPH2
23	pituitary tumor	13.6	CGA, FSHB, CDC25C, GNRHR, SSTR1, SSTR2
24	delayed puberty	13.6	KISS1R, CGA, FSHB, GNRHR, CYP17A1, CYP19A1
25	sex reversal	13.6	ZFY, CGA, AR, CYP19A1, SRY, RSPO1
26	micropenis	13.6	CGA, AR, CYP17A1, SRD5A1, SRD5A2
27	mayer-rokitansky-kuster-hauser syndrome	13.6	WNT4, WNT5A, WNT7A, WNT9B
28	luteoma	13.6	CGA, CYP21A2, SRY
29	turner syndrome	13.5	ZFY, CGA, FOXP3, AR, TPH1, DAZ1
30	anovulation	13.5	CGA, FSHB, CYP19A1, CYP21A2, SRD5A1, SHBG
31	androgen insensitivity syndrome, partial	13.5	AR, CYP19A1, SRD5A1, SHBG
32	hypertrophic cardiomyopathy	13.5	MYH7B, AR, CALR3, CALR, TNNT1, TNNT2
33	hypopituitarism	13.5	CGA, FSHB, GLI2, CYP19A1, CYP21A2, SRY
34	giant cell hepatitis	13.4	CYP1A1, CYP1A2, CYP1B1, CYP2A7P1, CYP17A1, CYP21A2
35	androgenetic alopecia	13.4	AR, CYP19A1, CYP21A2, SRD5A1, SRD5A2, SHBG
36	virilization	13.4	CGA, FSHB, AR, CYP17A1, CYP19A1, CYP21A2
37	klinefelter's syndrome	13.4	KISS1R, CGA, AR, GNRHR, DAZ4, CYP19A1
38	hypospadias	13.4	CGA, AR, DAZ4, CYP1A1, CYP17A1, CYP21A2
39	amenorrhea	13.3	CGA, FSHB, AR, CYP17A1, CYP19A1, SRY
40	horizontal gaze palsy with progressive scoliosis	13.3	ROBO1, ROBO2, ROBO3, ROBO4
41	hypogonadism	13.3	KISS1R, CGA, FSHB, FOXN1, AR, GNRHR
42	familial male-limited precocious puberty	13.3	KISS1R, CGA, FSHB, GNRHR, CYP19A1, CYP21A2
43	arthrogryposis	13.3	TNNT3, CPNE8, MYH2, MYH3, MYH6, MYH8
44	substance dependence	13.3	GSTP1, HTR1B, TPH1, OPRD1, OPRK1, OPRL1
45	hypogonadotropism	13.2	KISS1R, CGA, FSHB, GNRHR, CYP1A1, CYP19A1
46	antley-bixler syndrome	13.2	CYP1A2, CYP1B1, CYP17A1, CYP19A1, CYP21A2
47	prostatic hypertrophy	13.2	AR, GSTP1, CYP19A1, SRD5A1, SRY, SHBG
48	autism spectrum disorder	13.2	FOXP2, AR, MCHR1, HTR1B, HTR1E, TPH2
49	transsexualism	13.2	AR, CYP17A1, CYP19A1, CYP21A2, SRD5A2, SHBG
50	autoimmune polyendocrine syndrome type 1	13.2	TPH1, CYP1A2, CYP17A1, CYP21A2

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to hermaphroditism:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.5	LRP2, KISS1R, BRCA2, RAD23B, LIN9, BDKRB2
2	no phenotypic analysis	MP:0003012	9.7	LRP2, RAB27B, LIN9, ATP9A, FOXP2, FOXP3
3	respiratory system phenotype	MP:0005388	9.7	LRP2, MYLPF, FOXP1, FOXP2, FOXP4, HSPB8
4	immune system phenotype	MP:0005387	9.5	NCEH1, KISS1R, PCGF3, BRCA2, RAD23B, LIN9
5	vision/eye phenotype	MP:0005391	9.4	LRP2, RAB27A, RAD23B, KAT6B, FRS2, FOXN4
6	muscle phenotype	MP:0005369	9.4	MYH1, MYLPF, UTS2R, KAT6B, FOXP1, FOXP2
7	craniofacial phenotype	MP:0005382	9.2	LRP2, RAD23B, KAT6A, KAT6B, FRS2, FOXP2
8	renal/urinary system phenotype	MP:0005367	9.1	LRP2, KISS1R, BDKRB1, BDKRB2, FOXP3, AR
9	normal phenotype	MP:0002873	9.1	KISS1R, BRCA2, RAB27B, RAD23A, RAD23B, BDKRB1
10	skeleton phenotype	MP:0005390	9.1	LRP2, BRCA2, MYH1, BDKRB2, KAT6A, KAT6B
11	integument phenotype	MP:0010771	8.8	KISS1R, BRCA2, RAB27B, RAB27A, RAD23B, BDKRB1
12	digestive/alimentary phenotype	MP:0005381	8.8	LRP2, KISS1R, BRCA2, RAD23B, LIN9, BDKRB2
13	embryogenesis phenotype	MP:0005380	8.8	LRP2, BRCA2, RAD23B, LIN9, FRS2, CDK8
14	nervous system phenotype	MP:0003631	8.6	KISS1R, RBFOX1, RBFOX2, RAB27B, RAB27A, LIN9
15	cellular phenotype	MP:0005384	8.2	LRP2, NCEH1, RBFOX2, BRCA2, RAB27A, RAD23A
16	behavior/neurological phenotype	MP:0005386	7.9	LRP2, KISS1R, RBFOX1, RBFOX2, BRCA2, MYH1
17	cardiovascular system phenotype	MP:0005385	7.9	NCEH1, MYLPF, RAD23B, UTS2R, BDKRB1, BDKRB2
18	mortality/aging	MP:0010768	7.5	LRP2, KISS1R, RBFOX1, RBFOX2, BRCA2, MYLPF
19	homeostasis/metabolism phenotype	MP:0005376	7.4	LRP2, NCEH1, KISS1R, RBFOX1, BRCA2, RAB27B
20	growth/size phenotype	MP:0005378	7.3	LRP2, KISS1R, RBFOX1, RBFOX2, BRCA2, MYH1
21	reproductive system phenotype	MP:0005389	INF	LRP2, KISS1R, RBFOX1, BRCA2, RAB27B, RAB27A

Articles related to hermaphroditism:

(show all 26)

id	Title	Authors	Year	Affiliating Genes
1	Expression of R-ras oncogenes in the hermaphroditic fish Kryptolebias marmoratus, exposed to endocrine disrupting chemicals. (19000778)	Rhee J.S.... Lee J.S.	2009	RRAS2
2	Chimerism in black southern African patients with true hermaphroditism 46,XX/47XY,+21 and 46,XX/46,XY. (19154517)	Ramsay M.... de Ravel T.	2009	SRY
3	Expression of gonadotropin alpha, follicle-stimulating hormone beta, and luteinizing hormone beta genes of the hermaphroditic fish Kryptolebias marmoratus exposed to octylphenol, 17beta estradiol, and tamoxifen. (19456401)	Rhee J.S.... Lee J.S.	2009	FSHB
4	XX Maleness and XX true hermaphroditism in SRY-negative monozygotic twins: additional evidence for a common origin. (18056774)	Maciel-Guerra A.T.... Guerra-Junior G.	2008	SRY
5	Gonadotropin-releasing hormone receptor (GnRHR) gene expression is differently modulated in gender types of the hermaphroditic fish Kryptolebias marmoratus by endocrine disrupting chemicals. (18280221)	Rhee J.S.... Lee J.S.	2008	GNRHR
6	Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation. (18085567)	Tomaselli S.... Grammatico P.	2008	RSPO1
7	Spontaneous ovulation in a true hermaphrodite with normal male phenotype and a rare 46,XX/47,XXY Klinefelter's mosaic karyotype. (17389808)	Kanaka-Gantenbein C.h.... Chrousos G.P.	2007	SRY
8	Aromatase immunoreactivity and the role of enzymes in steroid pathways for inducing sex change in the hermaphrodite gobiid fish Trim ma okinawae. (15916910)	Sunobe T.... Nagahama Y.	2005	CYP19A1
9	Screening for mutations in the WNT-4 gene in patients with 46,XX true hermaphroditism. (15589122)	Canto P.... Mendez J.P.	2004	WNT4
10	Hermaphroditism pathology (15785398)	Jaubert F.... Fellous M.	2004	SRD5A2
11	Applicability of the SHBG androgen sensitivity test in the differential diagnosis of 46,XY gonadal dysgenesis, true hermaphroditism, and androgen insensitivity syndrome. (15146368)	Krause A.... Hoepffner W.	2004	SHBG
12	True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene. (12793612)	Maier E.M.... Kuhnle U.	2003	SRY
13	True hermaphroditism with ambiguous genitalia due to a complicated mosaic karyotype: clinical features, cytogenetic findings, and literature review. (12503111)	Modan-Moses D.... Aviram-Goldring A.	2003	SRY
14	SRY gene expression in the ovotestes of XX true hermaphrodites. (11912443)	Ortenberg J.... Yee H.	2002	SRY
15	Molecular analysis in true hermaphroditism: demonstration of low-level hidden mosaicism for Y-derived sequences in 46,XX cases. (12215841)	Queipo G.... Kofman-Alfaro S.	2002	SRY
16	BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite. (11250747)	Bernard-Gallon D.J.... Bignon Y.J.	2001	BRCA2
17	SRY gene transferred to the long arm of the X chromosome in a Y- positive XX true hermaphrodite. (10602113)	Margarit E.... Ballesta F.	2000	SRY
18	Hermaphroditism pathology. (15847378)	Jaubert F.... Fellous M.	1999-2004	SRD5A2
19	A rare case of 46,XX true hermaphroditism with hidden mosaicism with sex-determining region Y chromosome-bearing cells in the gonads. (9652903)	Inoue H.... Nawata H.	1998	SRY
20	True hermaphroditism with 46,XY karyotype and a point mutation in the SRY gene. (7776083)	Hiort O.... Klaubert G.T.	1995	SRY
21	XX true hermaphroditism in southern African blacks: exclusion of SRY sequences and uniparental disomy of the X chromosome. (7702097)	Spurdle A.B.... Ramsay M.	1995	SRY
22	True hermaphroditism in a 46,XY individual, caused by a postzygotic somatic point mutation in the male gonadal sex-determining locus (SRY): molecular genetics and histological findings in a sporadic case. (8447323)	Braun A.... Kuhnle U.	1993	SRY, ZFY
23	The role of the sex-determining region of the Y chromosome (SRY) in the etiology of 46,XX true hermaphroditism. (1740318)	Berkovitz G.D.... Migeon C.J.	1992	SRY
24	Sex-determining region Y (SRY) in a patient with 46,XX true hermaphroditism. (1297452)	Tanoue A.... Matsuda I.	1992	SRY
25	True hermaphroditism in a wild sheep: A clinical report. (16726991)	Bunch T.D.... Olson R.E.	1991	CGA
26	Male pseudo-hermaphroditism. Prenatal factors (2345270)	Aguilar-Martinez P.... Viala J.L.	1990	AR

Genes related to hermaphroditism according to GeneCards:

(show top 50)    (show all 262)

id	Symbol	Description	Score	GeneCards Section Context
1	SRY	sex determining region Y	11.0	Publications
2	RSPO1	R-spondin 1	11.0	Publications
3	LOC100132202	golgin subfamily A member 6-like protein 1-like	10.9	Orthologs
4	LOC645202	golgin A6 family-like	10.9	Orthologs
5	ATP5L2	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2	10.9	Orthologs
6	STX19	syntaxin 19	10.9	Orthologs
7	FOXR2	forkhead box R2	10.9	Orthologs
8	NKX6-3	NK6 homeobox 3	10.9	Orthologs
9	GOLGA6L6	golgin A6 family-like 6	10.9	Orthologs
10	HSPB2-C11orf52	HSPB2-C11orf52 readthrough (non-protein coding)	10.9	Orthologs
11	GOLGA6L1	golgin A6 family-like 1	10.9	Orthologs
12	DAZ2	deleted in azoospermia 2	10.9	Orthologs
13	ALYREF	Aly/REF export factor	10.9	Orthologs
14	NKX6-1	NK6 homeobox 1	10.9	Orthologs
15	CPNE6	copine VI (neuronal)	10.9	Orthologs
16	CRIP1	cysteine-rich protein 1 (intestinal)	10.9	Orthologs
17	HSPB3	heat shock 27kDa protein 3	10.9	Orthologs
18	FOXR1	forkhead box R1	10.9	Orthologs
19	MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	10.9	Orthologs
20	WNT8A	wingless-type MMTV integration site family, member 8A	10.9	Orthologs
21	NKX6-2	NK6 homeobox 2	10.9	Orthologs
22	DAZ3	deleted in azoospermia 3	10.9	Orthologs
23	ZFY	zinc finger protein, Y-linked	10.9	Publications
24	LSM14B	LSM14B, SCD6 homolog B (S. cerevisiae)	10.9	Orthologs
25	DAZ4	deleted in azoospermia 4	10.9	Orthologs
26	STX1B	syntaxin 1B	10.9	Orthologs
27	GALR3	galanin receptor 3	10.9	Orthologs
28	CPNE9	copine family member IX	10.9	Orthologs
29	HSPB6	heat shock protein, alpha-crystallin-related, B6	10.9	Orthologs
30	FRS3	fibroblast growth factor receptor substrate 3	10.9	Orthologs
31	MYL7	myosin, light chain 7, regulatory	10.9	Orthologs
32	NDST2	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	10.9	Orthologs
33	NPBWR1	neuropeptides B/W receptor 1	10.9	Orthologs
34	MYL10	myosin, light chain 10, regulatory	10.9	Orthologs
35	WNT6	wingless-type MMTV integration site family, member 6	10.9	Orthologs
36	FOXN1	forkhead box N1	10.9	Orthologs
37	CYP2A7P1	cytochrome P450, family 2, subfamily A, polypeptide 7 pseudogene 1	10.9	Orthologs
38	DPY30	dpy-30 homolog (C. elegans)	10.9	Orthologs
39	NPBWR2	neuropeptides B/W receptor 2	10.9	Orthologs
40	ITPKA	inositol-trisphosphate 3-kinase A	10.9	Orthologs
41	AADACL2	arylacetamide deacetylase-like 2	10.9	Orthologs
42	ITPKC	inositol-trisphosphate 3-kinase C	10.9	Orthologs
43	WNT16	wingless-type MMTV integration site family, member 16	10.9	Orthologs
44	KCND1	potassium voltage-gated channel, Shal-related subfamily, member 1	10.9	Orthologs
45	AADAC	arylacetamide deacetylase	10.9	Orthologs
46	GOLGA6L2	golgin A6 family-like 2	10.9	Orthologs
47	RXFP3	relaxin/insulin-like family peptide receptor 3	10.9	Orthologs
48	RXFP4	relaxin/insulin-like family peptide receptor 4	10.9	Orthologs
49	CALR3	calreticulin 3	10.9	Orthologs
50	RNF40	ring finger protein 40, E3 ubiquitin protein ligase	10.9	Orthologs

Pathways related to hermaphroditism according to GeneDecks:

(show top 50)    (show all 59)

id	Pathway	Score	Top Affiliating Genes
1	Melanogenesis20	11.6	WNT9B, WNT1, WNT10A, WNT10B, WNT9A, WNT8B
2	Tight junction20	11.6	MYH4, MYH6, MYH7, MYH8, MYL2, MYL7
3	Basal cell carcinoma20	11.5	WNT16, WNT11, WNT10B, WNT10A, WNT1, GLI3
4	Development MAG-dependent inhibition of neurite outgrowth10	11.5	MYL7, MYL2, MYH8, MYH7, MYH6, MYH4
5	Development_MAG-dependent inhibition of neurite outgrowth41	11.4	MYL7, MYL2, MYH8, MYH7, MYH6, MYH4
6	Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases41	11.4	MYLPF, MYH13, MYH15, MYH2, MYH3, MYH4
7	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases10	11.4	MYL7, MYH1, MYLPF, MYH13, MYH15, MYH2
8	Cell adhesion Tight junctions10	11.4	MYH6, MYH7, MYH8, MYL2, MYL7, MYH4
9	Cell adhesion_Tight junctions41	11.4	MYH6, MYH7, MYH8, MYL2, MYL7, MYH4
10	Hedgehog Signaling in Mammals36	11.4	WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A
11	Human Embryonic Stem Cell Pluripotency36	11.4	WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A
12	Colorectal Cancer Metastasis36	11.4	WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A
13	Cell adhesion_Integrin-mediated cell adhesion and migration41	11.4	MYLPF, MYH13, MYH15, MYH2, MYH3, MYH4
14	Cell adhesion Integrin-mediated cell adhesion and migration10	11.4	MYL7, MYH1, MYLPF, MYH13, MYH15, MYH2
15	Nanog in Mammalian ESC Pluripotency36	11.4	WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B
16	Hedgehog signaling pathway20	11.4	WNT2, WNT16, WNT11, WNT10B, WNT10A, WNT1
17	Inhibitory action of Lipoxins on neutrophil migration41	11.4	MYH6, MYH7, MYH8, MYL2, MYL7, MYH4
18	Class A/1 (Rhodopsin-like receptors)38	11.4	OPRK1, OPRL1, NPBWR1, NPBWR2, GALR1, GALR3
19	Immune response _CCR3 signaling in eosinophils41	11.3	MYH2, MYH15, MYH13, MYLPF, MYH3, MYH4
20	Immune response CCR3 signaling in eosinophils10	11.3	MYL7, MYH1, MYLPF, MYH13, MYH15, MYH2
21	Presenilin-Mediated Signaling36	11.2	WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A
22	Viral myocarditis20	11.2	MYH8, MYH7, MYH6, MYH4, MYH3, MYH2
23	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	11.2	GALR2, GALR3, GALR1, NPBWR2, NPBWR1, OPRL1
24	Fc-GammaR-Mediated Phagocytosis in Macrophages36	11.1	MYL7, MYL2, MYH7, MYH4, MYH13, MYH7B
25	RhoA Pathway36	11.1	MYL7, MYL2, MYH8, MYH7, MYH6, MYH4
26	Wnt Signaling Pathway37	11.1	WNT4, WNT3A, WNT2B, WNT2, WNT11, WNT10B
27	Neuroactive ligand-receptor interaction20	11.0	GNRHR, HTR5A, HTR1F, HTR1E, HTR1D, HTR1B
28	GSK3 Signaling36	11.0	WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6
29	WNT Signaling36	11.0	WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6
30	Striated Muscle Contraction38	10.9	MYL2, MYH8, MYH6, MYH3, TNNT3, TNNT2
31	SNARE interactions in vesicular transport20	10.9	STX11, STX2, STX3, STX1A, STX4, STX19
32	Epithelial Tight Junctions36	10.9	MYH2, MYH3, MYH4, MYH6, MYH7, MYH8
33	RhoGDI Pathway36	10.9	MYH4, MYH6, MYH7, MYH8, MYL2, MYL7
34	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics34	10.8	STX11, STX2, STX3, STX1A, STX4, STX19
35	Wnt signaling pathway20	10.8	WNT9B, WNT9A, SMAD2, MAPK9, MAPK10, MAPK8
36	Actin Nucleation by ARP-WASP Complex36	10.7	MYL7, MYL2, MYH8, MYH7, MYH6, MYH4
37	Cation-coupled Chloride cotransporters38	10.6	SLC12A5, SLC12A7, SLC12A4, SLC12A6
38	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.5	TPH2, TPH1, HTR1F, HTR1E, HTR1D, HTR1B
39	Phase II conjugation38	10.5	CYP1A2, GSTP1, GSTA5, GSTA4, GSTA3, GSTA2
40	2-Naphthylamine and 2-Nitronaphtalene metabolism10	10.4	CYP1A2, CYP1A1, GSTA5, GSTA4, GSTA3, GSTA2
41	PAK Pathway36	10.4	MYH4, MYH6, MYH7, MYH8, MYL2, MYL7
42	Amine ligand-binding receptors38	10.4	HTR5A, HTR1F, HTR1E, HTR1D, HTR1B, HTR1A
43	2-Naphthylamine and 2-Nitronaphtalene metabolism41	10.4	CYP1A2, CYP1A1, GSTA5, GSTA4, GSTA3, GSTA2
44	Glutathione metabolism10	10.3	GSTA5, GSTA4, GSTA3, GSTA2, GSTA1, GSTP1
45	Pathways in cancer20	10.2	WNT5B, WNT5A, WNT4, WNT3A, WNT3, WNT2B
46	Metabolism of xenobiotics by cytochrome P45020	10.0	CYP1B1, CYP1A2, CYP1A1, GSTP1, GSTA5, GSTA4
47	Translation_Non-genomic (rapid) action of Androgen Receptor41	INF	WNT4, WNT3A, WNT3, WNT2B, WNT2, WNT16
48	Transcription_Androgen Receptor nuclear signaling41	INF	WNT9B, WNT9A, SRD5A2, , AR, SMAD3
49	Translation Non-genomic (rapid) action of Androgen Receptor10	INF	WNT6, WNT5B, WNT5A, WNT4, WNT3A, WNT2B
50	Transcription Androgen Receptor nuclear signaling10	INF	WNT9B, WNT9A, WNT8B, WNT8A, WNT7B, WNT7A

Compounds related to hermaphroditism according to GeneDecks:

(show top 50)    (show all 118)

id	Compound	Score	Top Affiliating Genes
1	(r)-(+)-blebbistatin42	11.4	MYL7, MYL2, MYH13, MYH15, MYH2, MYH3
2	(s)-(-)-blebbistatin42	11.4	MYH15, MYH7, MYH8, MYL2, MYL7, MYH6
3	(+-)-blebbistatin42	11.4	MYH8, MYH13, MYH15, MYH2, MYH3, MYH4
4	rc 16042	11.0	SSTR1, SSTR5, SSTR2, SSTR3, SSTR4
5	somatostatin42 18	12.0	SSTR1, SSTR2, SSTR3, SSTR5, SSTR4
6	cyclosomatostatin42	11.0	SSTR5, SSTR4, SSTR3, SSTR1
7	kinetensin32 18	11.8	CPA3, CPA5, CPA1, CPA6
8	noradrenochrome32 18	11.7	GSTA5, GSTP1, GSTA3, GSTA1, GSTA2, GSTA4
9	hydrochloric acid32 18	11.7	GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTP1
10	zolmitriptan32 9 9	12.6	HTR1A, HTR1B, HTR1D, HTR1F, CYP1A2
11	adrenochrome32 18	11.6	GSTP1, GSTA5, GSTA1, GSTA2, GSTA3, GSTA4
12	threonine32	10.6	CDC25C, RRAS2, CPEB1, CSNK1E, MYH7, STX1A
13	ellagic acid32 42	11.5	GSTA3, GSTA5, GSTP1, GSTA2, GSTA1, GSTA4
14	Glutathione9 18 9	12.5	ABCC3, ABCC2, ABCC1, HPGDS, GSTP1, GSTA5
15	eletriptan32 9 9	12.4	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F
16	pcbs32	10.3	CPB1, CPA6, CYP21A2, CPB2, CYP1B1, CYP1A1
17	furosemide32 42 34 9 18 9	15.2	MAPK10, ABCC1, ABCC2, SLC12A5, AGTR1, SLC12A7
18	leuprolide acetate32	10.1	SHBG, CYP21A2, CYP19A1, GNRHR, CGA, FSHB
19	rizatriptan32 9 9	12.1	CYP1A2, HTR1D, HTR1F, HTR1B
20	mk 57132 42	11.0	GSTP1, ABCC6, ABCC3, ABCC2, ABCC1
21	sulfinpyrazone32 9 9	12.0	ABCC6, ABCC3, ABCC2, ABCC1, GSTP1
22	pcb 12632	9.9	CYP19A1, CYP17A1, CYP1B1, CYP1A1, CYP21A2
23	adenylate32	9.8	CGA, DAZL, MAPK10, BDKRB2, GALR1, FSHB
24	tbhq32	9.7	ABCC1, ABCC2, GSTP1, MAPK8, GSTA2, CYP1A1
25	clozapine32 34 9 9	12.5	HTR1E, HTR1A, HTR1B, HTR1D, CYP1A1, CYP1A2
26	calcium32 9 18 9	12.4	SSTR2, STX2, OPRD1, OPRK1, OPRL1, OPRM1
27	etoposide32 42 9 9	12.4	HSPB1, ABCC2, ABCC1, GSTP1, CGA, CDC25C
28	melatonin32 42 9 18 9	13.4	GNRHR, AGTR1, CYP21A2, CYP19A1, CYP1B1, CALR
29	sulforaphane32	9.3	ABCC2, CYP1A1, MAPK8, GSTP1, GSTA1, CDC25C
30	norepinephrine32 9 18 9	12.2	TPH1, HTR1D, HTR1A, MAPK10, CGA, STX1A
31	quercetin32 42 9 18 9	13.2	GSTP1, GSTA1, AR, ATP5B, CYP1B1, MAPK8
32	doxorubicin32 34 9 9	11.9	CGA, CDC25C, CDC25A, AR, GSTP1, ABCC6
33	tyrosine32	8.8	FER, FES, FOXP2, CDC25A, CDC25B, CDC25C
34	arginine32	8.5	CALR, HSPB2, AGTR1, HSPB1, GNRHR, MCHR1
35	cycloheximide32	8.2	HSPB1, CYP1A1, BRCA2, CYP1B1, CYP17A1, CYP19A1
36	flutamide32 9 9	INF	CYP1B1, , SHBG, CYP19A1, CYP1A2, CYP1A1
37	estradiol32 9 18 9	INF	SRD5A2, CYP19A1, , SRY, SMAD2, SHBG
38	genistein32 9 18 9	INF	ABCC2, BDKRB1, BRCA2, CDC25C, AR, MAPK8
39	progesterone32 42 9 18 9	INF	CPEB1, OPRK1, FSHB, BRCA2, WNT10B, WNT4
40	testosterone32 9 18 9	INF	BRCA2, CGA, , SRD5A2, SRY, SMAD3
41	ketoconazole32 42 9 18 9	INF	AR, CYP1A2, CYP1B1, CYP17A1, CYP19A1, CYP21A2
42	estrogen32	INF	, SSTR2, CYP21A2, SRD5A2, MYH6, SMAD3
43	androstenedione32 18	INF	SHBG, CYP21A2, CGA, SRD5A2, CYP1A1, CYP1A2
44	goserelin32 9 9	INF	SHBG, , CYP19A1, GNRHR, CGA
45	17beta-hydroxysteroid32	INF	CGA, AR, CYP1B1, SRD5A2, , CYP21A2
46	retinoic acid32 42 18	INF	CYP1A2, CYP1B1, WNT3A, CYP19A1, , SHBG
47	gnrh32	INF	POU2F2, , SHBG, CDC25C, SMAD3, KISS1R
48	spironolactone32 42 34 9 9	INF	AGTR2, AGTR1, AR, CYP21A2, , SHBG
49	dehydroepiandrosterone sulfate32	INF	CYP21A2, CGA, AR, CYP17A1, CYP19A1,
50	dihydrotestosterone32 9 18 9	INF	CGA, SRD5A2, CYP21A2, SRY, SMAD2, CYP19A1

Cellular components related to hermaphroditism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	myosin filament	GO:032982	11.0	MYH4, MYH6, MYH7, MYH8, MYH3, MYH2
2	myofibril	GO:030016	10.9	MYL2, MYH8, MYH6, MYH4, MYH3, MYH2
3	proteinaceous extracellular matrix	GO:005578	10.7	CALR, WNT6, WNT7A, WNT7B, WNT8A, WNT8B
4	muscle myosin complex	GO:005859	10.3	MYH8, MYH7, MYH6, MYH4, MYH2, MYH13
5	sarcomere	GO:030017	10.3	MYL2, MYH7, MYH6, MYH4, MYH2, TNNT2
6	cell surface	GO:009986	9.5	ROBO2, WNT1, WNT3A, WNT4, WNT5A, WNT5B
7	integral to plasma membrane	GO:005887	9.0	AGTR2, AGTR1, ABCC3, ABCC2, ABCC1, RXFP3
8	plasma membrane	GO:005886	8.9	AGTR1, AGTR2, STX4, STX1A, OPRD1, OPRK1

Biological processes related to hermaphroditism according to GeneDecks:

(show all 35)

id	Name	GO ID	Score	Top Affiliating Genes
1	neuron differentiation	GO:030182	11.3	WNT6, WNT7B, WNT8B, WNT9A, WNT9B, WNT5B
2	cellular response to retinoic acid	GO:071300	11.3	WNT9B, WNT9A, WNT8B, WNT7B, WNT6, WNT5B
3	muscle filament sliding	GO:030049	11.2	MYL2, MYH8, MYH7, MYH6, MYH4, MYH3
4	canonical Wnt receptor signaling pathway	GO:060070	11.2	RSPO1, MYH6, WNT8A, WNT7B, WNT7A, WNT5A
5	muscle contraction	GO:006936	11.1	MYH8, MYH7, MYH6, MYH4, MYH2, MYH13
6	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:007187	11.0	OPRD1, SSTR5, SSTR4, SSTR3, SSTR2, SSTR1
7	spermatogenesis	GO:007283	11.0	DAZ2, DAZ3, DAZ4, DAZL, SSTR2, SSTR3
8	somatostatin signaling pathway	GO:038170	11.0	SSTR5, SSTR4, SSTR3, SSTR2, SSTR1
9	cornea development in camera-type eye	GO:061303	11.0	WNT9B, WNT9A, WNT6, WNT2B
10	positive regulation of canonical Wnt receptor signaling pathway	GO:090263	10.9	WNT4, WNT3A, WNT2B, WNT2, WNT10B, CSNK1E
11	mammary gland epithelium development	GO:061180	10.9	WNT7B, WNT4, WNT3, WNT2
12	cell-cell signaling	GO:007267	10.9	WNT3A, WNT4, WNT6, WNT7B, WNT9A, WNT9B
13	opioid receptor signaling pathway	GO:038003	10.8	NPBWR2, NPBWR1, OPRK1, OPRD1
14	G-protein coupled receptor signaling pathway	GO:007186	10.8	SSTR4, SSTR5, RXFP3, AGTR1, AGTR2, OPRD1
15	heparin biosynthetic process	GO:030210	10.8	NDST4, NDST3, NDST2, NDST1
16	synaptic transmission	GO:007268	10.8	OPRK1, NPBWR1, SLC12A5, CPNE6, GALR3, GALR2
17	positive regulation of dermatome development	GO:061184	10.7	WNT1, WNT3A, WNT4
18	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	GO:007193	10.7	OPRL1, OPRK1, OPRD1, SSTR5, SSTR2, MCHR1
19	ATP catabolic process	GO:006200	10.7	MYH7, DNA2, ABCC1, TNNT2, ATP5F1, ATP5B
20	glutathione metabolic process	GO:006749	10.6	GSTP1, GSTA5, GSTA4, GSTA3, GSTA2, GSTA1
21	palate development	GO:060021	10.6	WNT8A, WNT7A, WNT5A, WNT3A, WNT11, SMAD2
22	heparan sulfate proteoglycan biosynthetic process	GO:015012	10.6	NDST4, NDST3, NDST2, NDST1
23	positive regulation of meiosis	GO:045836	10.5	WNT5A, WNT4, DAZL
24	lung development	GO:030324	10.4	WNT7B, WNT2, SMAD2, CYP1A2, GLI3, GLI2
25	cellular response to hydrostatic pressure	GO:071464	10.3	WNT4, WNT10B, CYP19A1
26	positive regulation of transcription, DNA-dependent	GO:045893	10.3	WNT1, POU2F2, NSD1, AGTR2, WNT11, WNT3A
27	developmental growth	GO:048589	10.2	SMAD3, SMAD2, GLI3, GLI2, CGA
28	hindgut morphogenesis	GO:007442	10.1	WNT5A, GLI3, GLI2
29	negative regulation of apoptotic process	GO:043066	9.9	WNT1, WNT11, WNT4, WNT5A, WNT7A, ADAMTS20
30	axon midline choice point recognition	GO:016199	9.7	ROBO3, ROBO2, ROBO1
31	xenobiotic metabolic process	GO:006805	9.6	CYP1A2, CYP1B1, CYP17A1, CYP19A1, CYP21A2, CYP1A1
32	cellular response to estradiol stimulus	GO:071392	INF	WNT4, , SSTR3, SSTR2
33	androgen biosynthetic process	GO:006702	INF	WNT4, SRD5A2, , CYP17A1
34	response to drug	GO:042493	INF	SMAD1, ABCC1, ABCC6, SLC12A5, CPB2, NKX6-1
35	male gonad development	GO:008584	INF	WNT4, WNT2B, SRD5A2, , CYP19A1, AR

Molecular functions related to hermaphroditism according to GeneDecks:

(show all 22)

id	Name	GO ID	Score	Top Affiliating Genes
1	calmodulin binding	GO:005516	11.3	MYH8, MYH7, MYH6, MYH4, MYH3, MYH2
2	microfilament motor activity	GO:000146	11.1	MYL7, MYH7, MYH6, MYH4, MYH3, MYH2
3	metallocarboxypeptidase activity	GO:004181	11.1	CPO, CPB2, CPB1, CPA6, CPA5, CPA4
4	SNAP receptor activity	GO:005484	11.1	STX11, STX2, STX3, STX1A, STX4, STX19
5	structural constituent of muscle	GO:008307	11.0	MYL2, MYH8, MYH7, MYH6, MYH4, MYH2
6	receptor agonist activity	GO:048018	11.0	WNT1, WNT8A, WNT7A, WNT5A, WNT4, WNT3A
7	somatostatin receptor activity	GO:004994	10.9	SSTR5, SSTR4, SSTR3, SSTR2, SSTR1
8	frizzled binding	GO:005109	10.9	WNT8A, WNT5A, WNT4, WNT3, WNT2, WNT1
9	potassium:chloride symporter activity	GO:015379	10.8	SLC12A5, SLC12A7, SLC12A4, SLC12A6
10	actin binding	GO:003779	10.8	MYH2, MYH3, MYH4, MYH6, MYH7, MYH15
11	serotonin receptor activity	GO:004993	10.7	HTR5A, HTR1F, HTR1E, HTR1D, HTR1B, HTR1A
12	[heparan sulfate]-glucosamine N-sulfotransferase activity	GO:015016	10.7	NDST4, NDST3, NDST2, NDST1
13	galanin receptor activity	GO:004966	10.6	GALR2, GALR3, GALR1
14	serotonin binding	GO:051378	10.6	HTR1F, HTR1E, HTR1D, HTR1B, HTR1A
15	glutathione transferase activity	GO:004364	10.6	HPGDS, GSTP1, GSTA5, GSTA4, GSTA3, GSTA2
16	deacetylase activity	GO:019213	10.5	AADAC, NDST4, NDST3, NDST1
17	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	GO:030618	10.4	SMAD9, SMAD3, SMAD2, SMAD1
18	ATPase activity	GO:016887	10.1	MYH7, MYH6, DNA2, ABCC1, TNNT2, ATP5F1
19	JUN kinase activity	GO:004705	9.9	MAPK9, MAPK10, MAPK8
20	ATP binding	GO:005524	9.8	STK11, DNA2, ABCC6, ABCC3, ABCC2, ABCC1
21	iron ion binding	GO:005506	9.3	CYP21A2, CYP19A1, CYP17A1, CYP1B1, CYP1A2, CYP1A1
22	protein binding	GO:005515	7.4	RNF20, KPNA3, ABCC2, AGTR1, AGTR2, TIPRL