MCID: HRM002
MIFTS: 41

Hermaphroditism malady

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Hermaphroditism

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Summaries for Hermaphroditism

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MalaCards based summary: Hermaphroditism is related to mixed gonadal dysgenesis and pseudohermaphroditism. An important gene associated with Hermaphroditism is SRY (Sex Determining Region Y), and among its related pathways are Regulation of Androgen receptor activity and Deactivation of the beta-catenin transactivating complex. Affiliated tissues include breast, heart and prostate, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Related Diseases for Hermaphroditism

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Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1mixed gonadal dysgenesis30.5SHBG, SRY
2pseudohermaphroditism26.8AR, CGA, RSPO1, SHBG, SOX9, SRD5A2
346,xx ovotesticular disorder of sex development11.5
446xx sex reversal 111.3
5palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal11.1
646xy sex reversal 110.9
7actg2-related disorders10.5SRY, WNT4
8swyer syndrome10.4
9nodular neuronal heterotopia10.4SOX9, SRY
10dysmorphism-short stature-deafness-disorder of sex development syndrome10.4SOX9, SRY
1148,xxxy syndrome10.3SOX9, SRY
1246 xx gonadal dysgenesis10.3SOX9, SRY
13swyer-james syndrome10.3SOX9, SRY
14breast-ovarian cancer, familial, 210.3SOX9, SRY
15delayed sleep phase syndrome10.3SOX9, SRY
16short qt syndrome10.2SOX9, SRY
17meacham syndrome10.2SOX9, SRY
18craniofrontonasal dysplasia10.2AR, SHBG
19penile cancer10.1SHBG, WNT4
20alternating hemiplegia of childhood10.1SOX9, SRY
21gonadal dysgenesis10.1
22movement disease10.1AR, SRY
23ehlers-danlos syndrome progeroid type10.1AR, SHBG
24urinary schistosomiasis10.1SHBG, SRY, WNT4
25anorectal atresia10.1CGA, SRY
26scleromalacia perforans10.1AR, SHBG
27gonadoblastoma10.1
28mixed connective tissue disease10.1SHBG, SRY
29testicular spermatocytic seminoma10.1CGA, SRY
30siberian tick typhus10.1AR, SRD5A2
3146,xx testicular disorder of sex development10.0
32inguinal hernia10.0
33verrucous keratotic hemangioma10.0AR, SRD5A2
34leukorrhea10.0AR, SRD5A2
35hypospadias10.0
36seminoma10.0
37leech infestation9.9
38erythema infectiosum9.9CGA, SHBG
39gonadal dysgenesis xy type associated anomalies9.9
40palmoplantar keratoderma-xx sex reversal-predisposition to squamous cell carcinoma syndrome9.9
41androgen insensitivity9.9
42klinefelter's syndrome9.9
43vaginitis9.9
44freemartinism9.9
45hypogonadism9.9AR, SHBG, SRY
46large cell medulloblastoma9.9AR, SHBG
47hidradenitis suppurativa9.9AR, SHBG, SRY
48disease of mental health9.9AR, SHBG, SRY
49external ear disease9.8CGA, SHBG
50microcephaly9.8AR, SRD5A2, SRY

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to hermaphroditism

Symptoms for Hermaphroditism

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Drugs & Therapeutics for Hermaphroditism

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Drugs for Hermaphroditism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Docetaxelapproved, investigational, Approved May 1996Phase 31844114977-28-5148124, 9877265
Synonyms:
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoate
(2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
01885_FLUKA
114977-28-5
4-(Acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
AC-383
AC1L3WHJ
ANX-514
BIND-014
C11231
CHEBI:4672
CHEMBL92
CID148124
D07866
DB01248
Docefrez
Docetaxel
Docetaxel (INN)
Docetaxel anhydrous
Docetaxel, Trihydrate
EmDOC
 
HMS2089K08
InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,5
MolPort-003-847-005
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-Boc-10-deacetyl taxol
NSC-628503
PSMA-targeted docetaxel nanoparticle
RP-56976
SDP-014
TXL
Taxotere
Taxotere (TN)
Taxotere(R)
XRP-6976L
docetaxel
docetaxel 114977-28-5
nchembio.188-comp8
nchembio.2007.34-comp7
nchembio.573-comp11
nchembio853-comp8
2Tubulin ModulatorsPhase 34279
3
ramucirumabPhase 362
Synonyms:
IMC-1121B
 
IMC-3G3
ramucirumab
4Antimitotic AgentsPhase 34296
5
Epinephrineapproved83451-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenaclick
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Auvi-q
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine bitartrate
Epinephrine chloride
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr
Epipen Jr.
Epipen Jr. Auto-Injector
Epipen jr
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
 
Esphygmogenina
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
Primatene Mist Refill
Prime Asthma Relief
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
6Anti-Inflammatory Agents, Non-Steroidal3549
7Antirheumatic Agents8496
8Anti-Inflammatory Agents8478
9Peripheral Nervous System Agents18510
10Psychotropic Drugs5501
11Epinephryl borate834
12Racepinephrine834
13Analgesics9358
14Analgesics, Non-Narcotic5184

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Ramucirumab (LY3009806) Plus Docetaxel in Participants With Urothelial CancerRecruitingNCT02426125Phase 3
2Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast CancerRecruitingNCT02474641Phase 3
3Qualitative Research on Women With Congenital Adrenal HyperplasiaCompletedNCT00559078
4Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in FranceCompletedNCT01211652
5National Survey on AsthmaCompletedNCT00770250
6Decision Support for Parents Receiving Information About Child's Rare DiseaseRecruitingNCT01875640
7Gene Polymorphisms Influencing Steroid Synthesis and ActionWithdrawnNCT00485186

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

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Anatomical Context for Hermaphroditism

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MalaCards organs/tissues related to Hermaphroditism:

33
Breast, Heart, Prostate, Thyroid, Endothelial, B cells, T cells

Animal Models for Hermaphroditism or affiliated genes

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MGI Mouse Phenotypes related to Hermaphroditism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.3AR, CGA, RSPO1, SOX9, SRD5A2, WNT4
2MP:00053797.2AR, CGA, RSPO1, SOX9, SRD5A2, WNT4

Publications for Hermaphroditism

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Articles related to Hermaphroditism:

(show top 50)    (show all 443)
idTitleAuthorsYear
1
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. (24742721)
2014
2
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. (23727055)
2013
3
Evolutionary transitions among dioecy, androdioecy and hermaphroditism in limnadiid clam shrimp (Branchiopoda: Spinicaudata). (19702888)
2009
4
Surgical treatment of hermaphroditism: experience with 25 cases. (19806042)
2009
5
Sry-negative XX true hermaphroditism in a roe deer. (18524504)
2009
6
Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation. (18085567)
2008
7
First colored illustration and detailed description of hermaphroditism by a Turkish surgeon, Serefeddin SabuncuoA9lu, in the 15th century. (18046159)
2007
8
Hermaphroditism: What's not to like? (17184795)
2007
9
True hermaphroditism with characteristics of Klinefelter's syndrome: a rare presentation. (16042329)
2005
10
Screening for mutations in the WNT-4 gene in patients with 46,XX true hermaphroditism. (15589122)
2004
11
An unusal case of hermaphroditism--a 46,XX/69,XXY chimera. (15270409)
2004
12
Bipolar hermaphroditism of somatic cell as the basis of its being and becoming: celldom appreciated. (12432206)
2002
13
Management of the African child with true hermaphroditism. (11172444)
2001
14
SRY gene transferred to the long arm of the X chromosome in a Y- positive XX true hermaphrodite. (10602113)
2000
15
An unusual case of delusional misidentification: 'delusional hermaphroditism'. (10364732)
1999
16
Vaginal stone in a male patient with true hermaphroditism. (9488939)
1997
17
True hermaphroditism in a wild sheep: A clinical report. (16726991)
1991
18
Sexuality and hermaphroditism in fishes. I. Synchronous functional hermaphroditism in the serranid fish Serranus scriba L. (2341087)
1990
19
True hermaphroditism: a new case with complex mosaicism. (2222927)
1990
20
Gender dysphoria in a child with true hermaphroditism. (3676994)
1987
21
Is true hermaphroditism a primary germ cell disorder? (3601818)
1987
22
Nephroblastoma in an ovotestis of a true hermaphrodite: a case report. (3033335)
1987
23
Plasma androgens during the luteal phase in a case of true hermaphroditism with bilateral ovotestis. (3159938)
1985
24
Whistling maids and crowing hens--hermaphroditism in folklore and biology. (7290904)
1981
25
Hermaphroditism. (7398198)
1980
26
Clinical, cytogenetical, histological, immunological and hormonal studies in a case of true hermaphroditism. (7428182)
1980
27
True hermaphroditism: a clinical description and a proposed function for the long arm of the Y chromosome. (671194)
1978
28
True hermaphroditism: etiology and phenotypic considerations. (365271)
1978
29
Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog. (675252)
1978
30
Report of a case of true hermaphroditism with karyotype 45,X/46,XX/46,X,mar/47,XX,mar. (563432)
1977
31
Gonadoblastoma in a true hermaphrodite with a 46,XX karyotype. (1250564)
1976
32
A case of true hermaphroditism presenting as an undescended testicle. (4154009)
1974
33
True hermaphroditism with XX-XY mosaicism: report of a case. (4737577)
1973
34
High incidence of true hermaphroditism in the early human embryos. (5163617)
1971
35
A possible correlation between chromosomal pattern and gonadal morphology in cases of mixed gonadal dysgenesis, XO-XX and XO-XY mosaicism, true hermaphrodites and XX males. (5649946)
1968
36
Staff conference: University of Tennessee Hospital: hermaphroditism. (5934680)
1966
37
X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome. (4161595)
1966
38
"Mixed" gonadal dysgenesis: a variety of hermaphroditism. (13989874)
1963
39
True hermaphroditism: including a case with chromosome analysis. (14024009)
1962
40
Problems and management of hermaphroditism. (13894000)
1962
41
A case of true hermaphroditism. (13753582)
1960
42
Sex differences in human nuclei with particular reference to the Klinefelter syndrome, gonadal agenesis and other types of hermaphroditism. (13381386)
1956
43
Roentgenological differential diagnosis of simple hypospadia from hypospadia in hermaphroditism]. (13083763)
1953
44
True hermaphroditism. (14888497)
1952
45
A case of hermaphroditism. (14821342)
1951
46
Hermaphroditism and its treatment. (15423773)
1950
47
True hermaphroditism. (20279555)
1946
48
TRUE HERMAPHRODITISM: REPORT OF A CASE WITH NECROPSY. (17856731)
1936
49
Case of Supposed Hermaphroditism. (19975258)
1911
50
Case of Hermaphroditism in a Common Frog (Rana temporaria). (17231850)
1890

Variations for Hermaphroditism

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Expression for genes affiliated with Hermaphroditism

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Search GEO for disease gene expression data for Hermaphroditism.

Pathways for genes affiliated with Hermaphroditism

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GO Terms for genes affiliated with Hermaphroditism

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Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1male sex determinationGO:003023810.0SOX9, SRY
2cellular response to transforming growth factor beta stimulusGO:007156010.0SOX9, WNT4
3sex differentiationGO:000754810.0AR, WNT4
4cell fate commitmentGO:00451659.9SOX9, WNT4
5prostate gland developmentGO:00308509.8AR, SOX9
6epithelial to mesenchymal transitionGO:00018379.7SOX9, WNT4
7cell differentiationGO:00301549.5SOX9, SRY, WNT4
8male gonad developmentGO:00085849.4SOX9, SRD5A2, WNT4
9positive regulation of transcription, DNA-templatedGO:00458938.8AR, SOX9, SRY, WNT4
10cell-cell signalingGO:00072678.6AR, CGA, SRD5A2

Sources for Hermaphroditism

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet