Hernia malady

MedlinePlus: A hernia occurs when part of an internal organ bulges through a weak area of muscle. most hernias occur in the abdomen. there are several types of hernias, including inguinal, the most common type, is in the groin umbilical, around the belly button incisional, through a scar hiatal, a small opening in the diaphragm that allows the upper part of the stomach to move up into the chest. congenital diaphragmatic, a birth defect that needs surgery hernias are common. they can affect men, women and children. a combination of muscle weakness and straining, such as with heavy lifting, might contribute. some people are born with weak abdominal muscles and may be more likely to get a hernia. the usual treatment for a hernia is surgery to repair the opening in the muscle wall. untreated hernias can cause pain and health problems.²³

MalaCards: Hernia is related to congenital diaphragmatic hernia and hiatus hernia. An important gene associated with Hernia is DIH1 (diaphragmatic hernia 1), and among its related pathways are Actin-Based Motility by Rho Family GTPases and ERK5 Signaling. The compounds nitroglycerin and l-nmma have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and thyroid, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia: A hernia is the protrusion of an organ or the fascia of an organ through the wall of the cavity that...⁴⁴ more...

hernia 7 17 32 23 43

Diseases related to hernia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 816)

id	Related Disease	Score	Top Affiliating Genes
1	congenital diaphragmatic hernia	36.3	FGF7, GRP, WT1
2	hiatus hernia	33.4	PAH, MUSTN1, LAT2, LAX1, ATP4A, ATP12A
3	fryns syndrome	30.7	ZFPM2, DISP1, HLX
4	diaphragmatic eventration	30.3	ZFPM2, FBN1, STRA6
5	hypertension	30.2	NOS2, NOS3, ACE, AGT, AGTR1
6	pulmonary hypertension	29.7	SFTPB, SFTPC, HTR3A, NOS2, NOS3, EDN1
7	wagr syndrome	29.7	PAX6, IGF2, WT1, H19
8	microphthalmia	28.4	PAX3, PAX6, CCDC102B, TMX3, SHH, HCCS
9	abdominal aortic aneurysm	27.9	MMP1, MMP13, MMP2, MMP9, FBN1, CCL2
10	congenital heart defect	27.8	PIK3C2A, IDUA, HMOX1, ACE, HBG2, AGTR1
11	spina bifida	27.5	PAX3, CGB7, CCL2, IGHE, ALDH1A2, CYP26A1
12	respiratory failure	24.4	PIK3C2A, SFTPB, SFTPC, RBP4, PAOX, SCGB1A1
13	aortic aneurysm	22.4	PIK3C2A, MMP1, MMP13, MMP2, MMP9, FGF2
14	thyroiditis	19.3	PIK3C2A, LRP2, SFTPB, SFTPC, RBP4, SERPINB1
15	blindness	18.5	PIK3C2A, RBP4, PAX6, KDR, CD36, MMP1
16	abrikosov's tumor	14.1	ZFPM2, KDR, LHCGR, PDGFRA, WT1, HIF1A
17	adenomatoid tumor	14.0	MMP2, WT1, ELN, NKX2-1
18	hemihypertrophy	14.0	CDKN1C, IGF2, WT1, H19
19	newborn respiratory distress syndrome	14.0	SFTPB, GRP, NKX2-1
20	mucopolysaccharidosis i	14.0	FGF2, IDUA, ELN
21	nephroblastoma	14.0	PAX3, PAX6, CDKN1C, IGF2, PDGFRA, WT1
22	pediatric cns embryonal cell carcinoma	14.0	LRP2, RARB, PAX6, CGB7, MEF2A, CYP26A1
23	embryonal cancer	13.9	IGF2, TGFA, H19
24	pre-eclampsia	13.9	NOS3, EDN1, EDNRA, AGT
25	thoracic aortic aneurysm	13.9	MMP1, MMP2, FBN1, ELN
26	cerebellar hypoplasia	13.9	SFTPB, SFTPC, PAX6, LHCGR, FGF10, NKX2-1
27	renal tubular dysgenesis	13.9	ACE, AGT, AGTR1
28	large cell carcinoma	13.9	SFTPB, SFTPC, GRP, TIMP2, NKX2-1
29	orbit embryonal rhabdomyosarcoma	13.9	PAX3, IGF2, WT1, H19
30	raynaud disease	13.9	HTR3A, EDN1, AGTR1
31	oligohydramnios	13.9	EDN1, ACE, AGT, AGTR1, PRUNE
32	idiopathic pulmonary fibrosis	13.9	MMP1, MMP2, FGF2, TNF, EDN1
33	adrenocortical carcinoma	13.9	CDKN1C, IGF2, AGTR1, H19, GATA6, GATA4
34	imperforate anus	13.9	TEF, CYP26A1, STRA6, PRUNE
35	renal clear cell carcinoma	13.9	VHL, KDR, MMP2, HIF1A, THRA, TGFA
36	malignant hypertension	13.9	EDN1, ACE, AGT, AGTR1
37	postural orthostatic tachycardia syndrome	13.9	NOS2, NOS3, AGT, AGTR1
38	lacrimal duct obstruction	13.9	SFTPB, FGF7, HMOX1, PTGDS, ELN, AGTR1
39	posterior urethral valves	13.9	ACE, AGT, AGTR1
40	neurocirculatory asthenia	13.9	MMP1, FBN1, COL3A1, ACE, ELN, AGT
41	craniosynostosis	13.8	FGF10, FGF2, FGF7, FGFRL1, FBN1, PDGFRA
42	adrenal adenoma	13.8	VHL, CDKN1C, IGF2, AGTR1, H19
43	keloids	13.8	CD36, MMP1, MMP13, FGF2, LOX, ELN
44	sex reversal	13.8	PAX6, CGB7, AR, NR3C1, WT1, GATA4
45	glucocorticoid resistance	13.8	KDR, GRP, TNF, NR2F2, NR3C1, GAPDH
46	ectopic pregnancy	13.8	PIK3C2A, SCGB1A1, CGB7, MMP1, HOXA10, NOS2
47	cerebral aneurysms	13.8	ELANE, ELN, TIMP2
48	duodenogastric reflux	13.8	ATP4A, ATP12A, CCK, IDUA
49	esophageal atresia	13.8	FGF10, GRP, CALCA, TEF, SHH
50	impotence	13.8	NOS2, NOS3, EDN1, EDNRA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hernia:

²²

MGI Mouse Phenotypes related to hernia:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.3	LRP2, ZFPM2, PAX3, ZEB1, LHCGR, CHD2
2	liver/biliary system phenotype	MP:0005370	9.6	VHL, ZFPM2, CHD2, CD36, AR, IDUA
3	embryogenesis phenotype	MP:0005380	9.5	VHL, RARB, PAX3, PAX6, FGF10, FGFRL1
4	hematopoietic system phenotype	MP:0005397	9.5	SERPINB1, VHL, PAX3, ZEB1, CHD2, LAT2
5	hearing/vestibular/ear phenotype	MP:0005377	9.3	LRP2, RARB, PAX3, PAX6, ZEB1, FGF10
6	limbs/digits/tail phenotype	MP:0005371	9.3	VHL, RARB, PAX3, ZEB1, CDKN1C, ITGA3
7	renal/urinary system phenotype	MP:0005367	9.2	LRP2, VHL, RARB, PAX3, PAX6, PAH
8	nervous system phenotype	MP:0003631	9.0	PAX3, PAX6, PAH, ZEB1, CD36, CDKN1C
9	no phenotypic analysis	MP:0003012	8.8	LRP2, SFTPC, ZFPM2, PAX3, FBN1, AQP5
10	immune system phenotype	MP:0005387	8.8	SERPINB1, PAX3, PAX6, KDR, ZEB1, LHCGR
11	behavior/neurological phenotype	MP:0005386	7.9	LRP2, SFTPB, SFTPC, RARB, PAX6, PAH
12	growth/size phenotype	MP:0005378	7.8	PIK3C2A, LRP2, SFTPC, VHL, RARB, PAX3
13	reproductive system phenotype	MP:0005389	7.5	SFTPC, RBP4, VHL, RARB, ZFPM2, PAX3
14	skeleton phenotype	MP:0005390	7.5	LRP2, VHL, RARB, PAX3, KDR, ZEB1
15	vision/eye phenotype	MP:0005391	7.3	LRP2, SFTPC, RBP4, RARB, PAX3, PAX6
16	adipose tissue phenotype	MP:0005375	7.1	PIK3C2A, ZEB1, LHCGR, CHD2, CD36, AR
17	normal phenotype	MP:0002873	6.7	RBP4, VHL, RARB, ZFPM2, PAX3, PAX6
18	digestive/alimentary phenotype	MP:0005381	6.5	LRP2, VHL, RARB, PAX3, PAX6, ZEB1
19	mortality/aging	MP:0010768	6.5	PIK3C2A, SFTPB, SFTPC, SERPINB1, VHL, RARB
20	tumorigenesis	MP:0002006	INF	SFTPC, VHL, PAX3, PAX6, ZEB1, SCGB1A1
21	cardiovascular system phenotype	MP:0005385	INF	SFTPC, RBP4, VHL, RARB, ZFPM2, PAX3
22	craniofacial phenotype	MP:0005382	INF	LRP2, PAX3, PAX6, PAH, ZEB1, CDKN1C
23	respiratory system phenotype	MP:0005388	INF	LRP2, SFTPC, SERPINB1, ZFPM2, PAX3, PAX6
24	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, LRP2, SFTPB, RBP4, SERPINB1, VHL
25	integument phenotype	MP:0010771	INF	VHL, ZFPM2, PAX3, PAX6, PAH, ZEB1
26	muscle phenotype	MP:0005369	INF	RBP4, VHL, RARB, ZFPM2, PAX3, PAX6
27	cellular phenotype	MP:0005384	INF	LRP2, RBP4, SERPINB1, VHL, ZFPM2, PAX3

Articles related to hernia:

(show top 50)    (show all 91)

id	Title	Authors	Year	Affiliating Genes
1	Circulating matrix metalloproteinases and their inhib itors in inguinal hernia and abdominal aortic aneurysm. (21427648)	Antoniou G.A.... Lazarides M.K.	2011	MMP2, MMP9, TIMP2
2	A novel Arg615Ser mutation of androgen receptor DNA-b inding domain in three 46,XY sisters with complete androgen insensitivity syndr ome and bilateral inguinal hernia. (20888558)	Sharma V.... Jyothy A.	2011	AR
3	A novel EFNB1 mutation (c.712delG) in a family with c raniofrontonasal syndrome and diaphragmatic hernia. (20734337)	Hogue J.... Slavotinek A.	2010	EFNB1
4	Deletions of Xp provide evidence for the role of holo cytochrome C-type synthase (HCCS) in congenital diaphragmatic hernia. (20503342)	Qidwai K.... Scott D.A.	2010	HCCS
5	A maternally inherited chromosome 18q22.1 deletion in a male with late-presenting diaphragmatic hernia and microphthalmia-evaluation of DSEL as a candidate gene for the diaphragmatic defect. (20358601)	Zayed H.... Slavotinek A.M.	2010	CDH19, DSEL
6	Identification of TCTE3 as a gene responsible for con genital diaphragmatic hernia using a high-resolution single-nucleotide polymorp hism array. (21085971)	Teshiba R.... Yamamoto K.	2010	TCTE3
7	Collagen type III alpha I (COL3A1) is a Gastro-oesophageal reflux disease (GORD) susceptibility gene and a male risk factor for hiatus hernia (HH). (19398442)	Asling B.... LagerstrAPm-Fermer M.	2009	COL3A1
8	Hyper IgE syndrome with umbilical hernia. (20101344)	Hiremath N.C.... Soumya N.	2009	IGHE
9	Lysyl oxidase like-1 dysregulation and its contribution to direct inguinal hernia. (19292889)	Pascual G.... BellA^n J.M.	2009	SERPINB1, LOXL1
10	A case of complete androgen insensitivity syndrome pr esenting with incarcerated inguinal hernia: an immunohistochemical study. (19539906)	Papanastasopoulos P.... Georgiou G.	2009	AR, PTGDS
11	Deletion of 8p23.1 with features of Cornelia de Lange syndrome and congenital diaphragmatic hernia and a review of deletions of 8p23.1 to 8pter? A further locus for Cornelia de Lange syndrome. (18470924)	Baynam G.... Walpole I.	2008	TNKS
12	Denys-Drash syndrome and congenital diaphragmatic hernia: another case with the 1097G > A(Arg366His) mutation. (18203154)	Antonius T.... van Heijst A.	2008	WT1
13	Surfactant maturation is not delayed in human fetuses with diaphragmatic hernia. (17676984)	Boucherat O.... Bourbon J.R.	2007	FGF7
14	TGF-beta1 overexpression in the transversalis fascia of patients with direct inguinal hernia. (17537160)	Pascual G.... BellA^n J.M.	2007	MMP2
15	Genome-wide oligonucleotide-based array comparative g enome hybridization analysis of non-isolated congenital diaphragmatic hernia. (17210672)	Scott D.A.... Lee B.	2007	NR2F2
16	Candidate genes for congenital diaphragmatic hernia from animal models: sequencing of FOG2 and PDGFRalpha reveals rare variants in diaphragmatic hernia patients. (17568391)	Bleyl S.B.... Slavotinek A.M.	2007	PDGFRA, ZFPM2
17	Decreased lung fibroblast growth factor 18 and elastin in human congenital diaphragmatic hernia and animal models. (17303798)	Boucherat O.... Bourbon J.R.	2007	ELN, FGF18
18	Ghrelin expression in human and rat fetal lungs and the effect of ghrelin administration in nitrofen-induced congenital diaphragmatic hernia. (16549524)	Santos M.... Correia-Pinto J.	2006	GHRL
19	Association between WAGR syndrome and diaphragmatic hernia (17194330)	MartA-n Campagne E.... Tovar Larrucea J.A.	2006	WT1
20	Intervertebral disc cells produce tumor necrosis factor alpha, interleukin-1beta, and monocyte chemoattractant protein-1 immediately after herniation: an experimental study using a new hernia model. (15626982)	Yoshida M.... Matsukawa A.	2005	CCL2
21	Comparison of the plasma and hernia sac tissue copper levels in direct and indirect inguinal hernia patients. (16327059)	Kayaoglu H.A.... Aribal D.	2005	LOX
22	Congenital diaphragmatic hernia, tracheal occlusion, thyroid transcription factor-1, and fetal pulmonary epithelial maturation. (15764645)	Chapin C.J.... Kitterman J.A.	2005	NKX2-1
23	Congenital diaphragmatic hernia and chromosome 15q26: determination of a candidate region by use of fluorescent in situ hybridization and array-based comparative genomic hybridization. (15750894)	Klaassens M.... de Klein A.	2005	DIH1
24	Expression of vasoactive mediators during mechanical ventilation in nitrofen-induced diaphragmatic hernia in rats. (15756563)	Shinkai T.... Puri P.	2005	CALCA
25	Role of TIMP-2 in fascia transversalis on development of inguinal hernias. (16036783)	Abci I.... Altan A.	2005	TIMP2
26	Congenital diaphragmatic hernia: is 15q26.1-26.2 a candidate locus? (15057983)	Biggio J.R.... Holt R.L.	2004	MEF2A, DIH1
27	Upregulated expression of EGF and TGF-alpha in the proximal respiratory epithelium in the human hypoplastic lung in congenital diaphragmatic hernia. (14714133)	Guarino N.... Puri P.	2004	TGFA
28	Genetic polymorphisms of angiotensin system genes in congenital diaphragmatic hernia associated with persistent pulmonary hypertension. (15017542)	Solari V.... Puri P.	2004	ACE, AGTR1, AGT
29	Expression of angiogenesis-related factors in lungs of patients with congenital diaphragmatic hernia and pulmonary hypoplasia of other causes. (15549611)	de Rooij J.D.... de Krijger R.R.	2004	KDR, NOS3, HIF1A
30	Analysis of collagen-interacting proteins in patients with incisional hernias. (12607124)	Rosch R.... Schumpelick V.	2003	CD36
31	Down-regulation of sonic hedgehog expression in pulmonary hypoplasia is associated with congenital diaphragmatic hernia. (12547712)	Unger S.... Post M.	2003	SHH
32	Expression of heme oxygenase-1 and endothelial nitric oxide synthase in the lung of newborns with congenital diaphragmatic hernia and persistent pulmonary hypertension. (12720199)	Solari V.... Puri P.	2003	HMOX1, NOS3
33	Can laparoscopic hernia repair alter function and vol ume of testis? Randomized clinical trial. (14712099)	Akbulut G.... Dilek O.N.	2003	LHCGR
34	Effect of mechanical ventilation on the pulmonary expression and production of elastin in nitrofen-induced diaphragmatic hernia in rats. (12194112)	Guarino N.... Puri P.	2002	ELN
35	Thyroid transcription factor-1 expression during normal human lung development and in patients with congenital diaphragmatic hernia. (12194113)	Hosgor M.... de Krijger R.R.	2002	NKX2-1
36	Meconium thorax: A case of Bochdalek hernia and cecal perforation in a neonate with Job's syndrome. (11912536)	Butterworth S.A.... Webber E.M.	2002	IGHE
37	Upregulation of keratinocyte growth factor in the tracheal ligation lamb model of congenital diaphragmatic hernia. (11150451)	McCabe A.J.... Glick P.L.	2001	FGF7
38	Fibroblasts from the transversalis fascia of young patients with direct inguinal hernias show constitutive MMP-2 overexpression. (11176137)	BellA^n J.M.... BujA!n J.	2001	MMP2
39	In vitro effects of growth factors on lung hypoplasia in a model of congenital diaphragmatic hernia. (10873035)	Jesudason E.C.... Losty P.D.	2000	FGF2
40	Antenatal dexamethasone enhances surfactant protein synthesis in the hypoplastic lung of nitrofen-induced diaphragmatic hernia in rats. (11051153)	Guarino N.... Puri P.	2000	SFTPB
41	In vitro fusion of human inguinal hernia with associa ted epithelial transformation. (10765020)	Hutson J.M.... Hasthorpe S.	2000	CALCA
42	Abnormal collagen I to III distribution in the skin of patients with incisional hernia. (10720845)	Klinge U.... Klosterhalfen B.	2000	CD36
43	Systemic stress responses after laparoscopic or open hernia repair. (10890543)	UzunkAPy A.... Kocyigit A.	2000	TF, CRP, PIK3C2A
44	Increased tropoelastin and procollagen expression in the lung of nitrofen-induced diaphragmatic hernia in rats. (10359170)	Taira Y.... Puri P.	1999	CD36, ELN
45	Inguinal hernia repair in patients with coagulation p roblems: prevention of postoperative bleeding with human fibrin glue. (10076616)	Canonico S.... Santoriello A.	1999	F2, F3
46	Inguinal hernia revisited through comparative evaluat ion of peritoneum, processus vaginalis, and sacs obtained from children with he rnia, hydrocele, and undescended testis. (10235320)	Tanyel F.C.... BA1yA1kpamukAsu N.	1999	ITGA3
47	Retinol status of newborn infants with congenital dia phragmatic hernia. (9799371)	Major D.... Cloutier R.	1998	RBP4
48	Pathophysiology of congenital diaphragmatic hernia. XI: Anatomic and biochemical characterization of the heart in the fetal lamb CDH model. (7472946)	Karamanoukian H.L.... Azizkhan R.G.	1995	ELN
49	High coincidence of inguinal hernias and abdominal aortic aneurysms. (1599830)	Lehnert B.... Wadouh F.	1992	ELANE
50	Association of a new chromosomal deletion [del(1)(q32q42)] with diaphragmatic hernia: assignment of a human ferritin gene. (3162227)	Youssoufian H.... Jabs E.W.	1988	FTL

Genes related to hernia according to GeneCards:

(show top 50)    (show all 140)

id	Symbol	Description	Score	GeneCards Section Context
1	DIH1	diaphragmatic hernia 1	11.1	Publications, Aliases & Descriptions
2	AOCH	Acromegaloid features, overgrowth, cleft palate, and hernia	11.0	Aliases & Descriptions
3	DIH2	Hernia, congenital diaphragmatic 2	11.0	Aliases & Descriptions
4	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
5	FGF7	fibroblast growth factor 7	11.0	Publications
6	NKX2-1	NK2 homeobox 1	11.0	Publications
7	ELN	elastin	11.0	Publications
8	ZFPM2	zinc finger protein, multitype 2	11.0	Publications
9	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
10	WT1	Wilms tumor 1	11.0	Publications
11	IGLV6-57	immunoglobulin lambda variable 6-57	11.0
12	LRTM1	leucine-rich repeats and transmembrane domains 1	11.0
13	MUSTN1	musculoskeletal, embryonic nuclear protein 1	11.0
14	HCCS	holocytochrome c synthase	11.0	Publications
15	TCTE3	t-complex-associated-testis-expressed 3	11.0	Publications
16	HLX	H2.0-like homeobox	11.0	Publications
17	DSEL	dermatan sulfate epimerase-like	11.0	Publications
18	LAX1	lymphocyte transmembrane adaptor 1	11.0
19	YIPF6	Yip1 domain family, member 6	11.0
20	ARRDC4	arrestin domain containing 4	11.0
21	CAMLG	calcium modulating ligand	11.0
22	GKN1	gastrokine 1	11.0
23	TEF	thyrotrophic embryonic factor	11.0
24	FGFRL1	fibroblast growth factor receptor-like 1	11.0
25	EFNB1	ephrin-B1	11.0	Publications
26	LAT2	linker for activation of T cells family, member 2	11.0
27	PROZ	protein Z, vitamin K-dependent plasma glycoprotein	11.0
28	STRA6	stimulated by retinoic acid gene 6 homolog (mouse)	11.0	Publications
29	AQP5	aquaporin 5	11.0	Publications
30	CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	11.0	Publications
31	CGB7	chorionic gonadotropin, beta polypeptide 7	11.0	Publications
32	FGF18	fibroblast growth factor 18	11.0	Publications
33	LHCGR	luteinizing hormone/choriogonadotropin receptor	11.0	Publications
34	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
35	PRUNE	prune homolog (Drosophila)	11.0
36	CDH19	cadherin 19, type 2	11.0	Publications
37	TDH	L-threonine dehydrogenase	11.0
38	HOMER2	homer homolog 2 (Drosophila)	11.0	Publications
39	TMX3	thioredoxin-related transmembrane protein 3	11.0
40	SNX7	sorting nexin 7	11.0
41	HEPHL1	hephaestin-like 1	11.0
42	PAX6	paired box 6	11.0	Publications
43	NR2F2	nuclear receptor subfamily 2, group F, member 2	11.0	Publications
44	IDUA	iduronidase, alpha-L-	11.0
45	H19	H19, imprinted maternally expressed transcript (non-protein coding)	11.0
46	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0
47	SFTPB	surfactant protein B	11.0	Publications
48	ALDH1A2	aldehyde dehydrogenase 1 family, member A2	11.0	Publications
49	THRA	thyroid hormone receptor, alpha	11.0	Publications
50	COL3A1	collagen, type III, alpha 1	11.0	Publications

Pathways related to hernia according to GeneDecks:

(show top 50)    (show all 76)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.3	IGF1, FGF7, FGF18, FGF10
2	ERK5 Signaling36	10.3	PDGFRA, HGF, MEF2A, MEF2C, FGF18, KDR
3	ERK Signaling36	10.2	TGFA, TIMP2, PDGFRA, COL3A1, FBN1, FGF7
4	PTEN Pathway36	10.2	FGF18, ELN, PDGFRA, FBN1, FGF7, ITGA3
5	Glioma Invasiveness36	10.2	FGF7, HGF, TGFA, TIMP1, FGF2, FGF10
6	eNOS Signaling36	10.2	TIMP1, FGF18, AQP5, IGF2, NOS3, PDGFRA
7	Ras Pathway36	10.1	TIMP2, TGFA, TIMP1, IGF2, FGF7, FGF2
8	PPAR Pathway36	10.0	TNF, PDGFRA, TIMP2, IGF1, IGF2, FGF7
9	Activation of Matrix Metalloproteinases38	10.0	TIMP2, MMP1, MMP13, MMP2, ELANE, MMP9
10	Akt Signaling36	9.9	FGF18, FGF10, CCL2, TNF, FGF7, PDGFRA
11	14-3-3 Induced Intracellular Signaling36	9.9	FGF2, FGF10, FGF18, TIMP1, PDGFRA, TNF
12	Molecular Mechanisms of Cancer36	9.8	IGF2, HIF1A, PDGFRA, COL3A1, FBN1, FGF2
13	Pathways in cancer20	9.8	NOS2, HGF, TGFA, HIF1A, SHH, RARB
14	Paxillin Interactions36	9.7	FGF2, KDR, TIMP2, PDGFRA, IGF1, FGF7
15	Cell adhesion_ECM remodeling41	9.7	MMP13, MMP9, IGF2, MMP2, COL3A1, TIMP1
16	Telomerase Components in Cell Signaling36	9.7	KDR, FGF10, FGF2, FGF7, TNKS, FGF18
17	Cell adhesion ECM remodeling10	9.7	MMP1, MMP13, MMP2, TIMP2, TIMP1, COL3A1
18	p53 Mediated Apoptosis36	9.6	TIMP2, KDR, HGF, TGFA, TIMP1, PDGFRA
19	Apoptotic Pathways in Synovial Fibroblasts36	9.6	TIMP2, TIMP1, PDGFRA, IGF2, IGF1, TGFA
20	IP3 Pathway36	9.6	KDR, TIMP2, TGFA, FGF2, HGF, IGF1
21	Mitochondrial Apoptosis36	9.6	IGF2, IGF1, PDGFRA, TIMP2, TGFA, FGF7
22	Nuclear Receptor Activation by Vitamin-A36	9.6	HGF, TIMP2, IGF2, TIMP1, PDGFRA, RARB
23	Cellular Apoptosis Pathway36	9.6	IGF2, FGF7, IGF1, FGF10, TIMP2, TNF
24	Rac1 Pathway36	9.6	ITGA3, FGF10, KDR, FGF18, FGF2, FGF7
25	DHA Signaling36	9.6	IGF2, TGFA, TIMP2, FGF18, FGF2, FGF7
26	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.6	CDKN1C, TNF, AR, NR3C1, THRA, CALCA
27	eIF2 Pathway36	9.5	FGF18, HGF, TGFA, TIMP2, TIMP1, PDGFRA
28	NF-KappaB (p50-p65) Pathway36	9.5	FGF2, TGFA, TIMP2, TNF, IGF1, IGF2
29	Nanog in Mammalian ESC Pluripotency36	9.5	HGF, KDR, TIMP2, PDGFRA, IGF1, FGF10
30	NF-KappaB Family Pathway36	9.5	TNF, IGF1, KDR, FGF10, IGF2, FGF18
31	NFAT in Immune Response36	9.4	TGFA, IGF2, TIMP2, TIMP1, PDGFRA, IGF1
32	Activation of PKC through GPCR36	9.4	IGF1, IGF2, KDR, FGF10, FGF18, TIMP1
33	p70S6K Signaling36	9.3	HBG2, HGF, TGFA, TIMP2, TIMP1, F2
34	mTOR Pathway36	9.3	FGF10, TIMP1, FGF7, HIF1A, TIMP2, FGF2
35	Intracellular Calcium Signaling36	9.2	IGF2, MEF2A, MEF2C, FGF7, IGF1, HTR3A
36	Estrogen Pathway36	9.2	KDR, HGF, TIMP2, TIMP1, PDGFRA, NOS3
37	Phospholipase-C Pathway36	9.2	TIMP1, TIMP2, TGFA, HGF, MEF2C, FGF7
38	Rap1 Pathway36	9.1	IGF1, FGF7, FGF2, FGF18, FGF10, ITGA3
39	Angiogenesis3	9.1	PDGFRA, KDR, MMP9, HIF1A, FGF2, HMOX1
40	MAPK Signaling36	9.1	IGF1, ELN, HGF, TGFA, TIMP2, IGF2
41	PAK Pathway36	8.9	FGF10, HGF, CCL2, IGF2, FGF18, FGF2
42	JAK-STAT Pathway36	8.8	KDR, FGF18, FGF10, FGF2, FGF7, CCL2
43	p38 Signaling36	8.7	IGF1, HGF, CSF2, TGFA, PDGFRA, TNF
44	GSK3 Signaling36	8.6	CDH12, CDH18, KDR, CDH19, FGF10, HGF
45	Tec Kinases Signaling36	8.6	IGF1, TIMP1, PDGFRA, TNF, IGF2, TGFA
46	TGF-Beta Pathway36	8.6	TIMP1, TGFA, TIMP2, KDR, FGF10, FGF18
47	Pancreatic Adenocarcinoma36	8.5	MMP9, IGF1, KDR, MMP1, MMP13, HGF
48	Renin-Angiotensin Pathway36	8.3	PDGFRA, ACE, AGT, PTGS2, IGF1, IGF2
49	ILK Signaling36	8.0	COL3A1, TIMP1, HIF1A, ELN, PDGFRA, FGF18
50	Rho Family GTPases36	7.8	FBN1, FGF7, FGF10, ITGA3, CDH19, CDH18

Compounds related to hernia according to GeneDecks:

(show top 50)    (show all 328)

id	Compound	Score	Top Affiliating Genes
1	nitroglycerin32 9 9	12.6	ELANE
2	l-nmma32	10.3	CCK, IGHE, GHRL, NOS2, EDN1, EDNRA
3	egcg32	10.3	EDNRA, ELANE, TIMP1, TIMP2
4	hyaluronic acid32 18	10.8	SCGB1A1, CD36, MMP1, MMP13, FGF2, FGF7
5	doxycycline32 9 9	11.6	SFTPB, SFTPC, SCGB1A1, CDKN1C, MMP1, MMP13
6	h2o232	9.5	SERPINB1, PAH, FTL, IL1RAPL2, LOX, SMOX
7	ascorbic acid32 18	10.5	SFTPB, RBP4, CD36, MMP13, MMP2, AR
8	bleomycin32 9 9	11.4	SFTPB, SFTPC, CGB7, FGF2, FGF7, CCL2
9	paraffin32	9.3	SFTPB, KDR, CD36, MMP13, MMP2, AR
10	tgf beta132	9.2	KDR, CD36, MMP1, MMP13, MMP2, FGF2
11	pge232	9.1	SFTPB, LHCGR, MMP1, MMP13, AR, FGF2
12	aprotinin32 9 9	11.0	LRP2, MMP13, MMP2, MMP9, IGF1, IGHE
13	nitric oxide32 9 18 9	12.0	SFTPB, VHL, PAH, KDR, SCGB1A1, MMP13
14	n acetylcysteine32	8.9	KDR, MMP1, MMP2, MMP9, AR, IGHE
15	thymidine32 18	9.9	SFTPB, RARB, KDR, MMP13, FGF2, FGF7
16	calcitriol32 42 9 18 9	12.7	LRP2, RARB, CD36, AR, FGF2, GRP
17	matrigel32	8.7	KDR, CD36, MMP1, MMP13, MMP2, MMP9
18	arginine32	8.7	PIK3C2A, SFTPB, SFTPC, RARB, PAX6, PAH
19	epinephrine32 9 18 9	11.6	PIK3C2A, PAH, MMP1, MMP2, MMP9, GRP
20	testosterone32 9 18 9	11.5	PIK3C2A, RARB, LHCGR, CGB7, MMP1, MMP2
21	ribonucleic acid32	8.4	SFTPB, SFTPC, RBP4, RARB, LHCGR, MMP1
22	prednisolone32 9 9	10.4	PIK3C2A, MMP1, MMP13, MMP2, FGF2, IL1RAPL2
23	sb 20358032 42	9.4	CD36, MMP1, MMP13, MMP2, MMP9, FGF2
24	vitamin a32 9 18 9	11.3	LRP2, SFTPB, RBP4, RARB, SCGB1A1, AR
25	acetylcholine32 9 18 9	11.3	PIK3C2A, FGF7, GRP, CCK, IGHE, HTR3A
26	hydrocortisone32 9 9	10.3	KDR, CD36, MMP1, MMP2, FGF2, FGF7
27	cysteine32	8.1	SFTPB, SFTPC, RBP4, RARB, PAX3, PAH
28	ly29400232	8.1	PIK3C2A, VHL, MMP2, MMP9, FGF2, MEF2A
29	oxygen32 18	9.0	PIK3C2A, SFTPB, SFTPC, RBP4, PAX6, PAH
30	folate32	7.9	LRP2, RBP4, VHL, PAH, KDR, FTL
31	indomethacin32 9 9	9.8	KDR, MMP1, MMP13, GRP, IL1RAPL2, IGF2
32	histamine32 18	8.8	FGF7, GRP, IL1RAPL2, CCL2, CCK, IGF2
33	heparin32 9 18 9	10.7	PIK3C2A, LRP2, SERPINB1, CD36, MMP13, FGF10
34	losartan32 34 9 9	10.6	CD36, MMP1, CCL2, IGF1, ALB, CRP
35	cyclosporin a32 42	8.4	PIK3C2A, KDR, MMP1, MMP9, FGF2, FGF7
36	methotrexate32 34 42 9 9	11.2	PIK3C2A, CGB7, MMP1, MMP2, MMP9, IL1RAPL2
37	genistein32 9 18 9	10.1	RARB, KDR, CD36, MMP1, MMP13, MMP2
38	creatinine32	7.0	RBP4, SCGB1A1, MMP1, MMP2, MMP9, MEF2C
39	prostacyclin32	6.9	PIK3C2A, KDR, FGF2, CCL2, IGF2, LOX
40	alanine32	6.9	PIK3C2A, RBP4, PAX6, PAH, LHCGR, SCGB1A1
41	norepinephrine32 9 18 9	9.9	PIK3C2A, PAH, MMP1, MMP2, MMP9, GRP
42	vitamin d32	6.8	LRP2, RARB, PAH, ZEB1, CD36, AR
43	lactate32	6.4	PIK3C2A, RBP4, KDR, CGB7, MMP1, MMP2
44	retinoic acid32 42 18	8.4	LRP2, SFTPB, SFTPC, RBP4, RARB, PAX6
45	serine32	6.1	LRP2, SFTPB, RBP4, SERPINB1, VHL, PAX6
46	actinomycin d32	6.0	SFTPB, SFTPC, VHL, RARB, MMP13, MMP9
47	dexamethasone32 42 34 9 9	9.9	SFTPB, SFTPC, RBP4, RARB, KDR, FTL
48	cycloheximide32	5.3	SFTPB, SFTPC, RARB, PAX3, CD36, CDKN1C
49	estrogen32	5.3	RBP4, VHL, RARB, KDR, LHCGR, SCGB1A1
50	vegf32	INF	PIK3C2A, SFTPB, SFTPC, VHL, PAX6, KDR

Cellular components related to hernia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:045121	10.2	EDNRA, SHH, TNF, CD36, LAX1, LAT2
2	extracellular region	GO:005576	5.5	CCK, CCL2, IGF2, FBN1, FGF7, FGF2
3	extracellular space	GO:005615	INF	HGF, IGF1, IGF2, CCK, FBN1,

Biological processes related to hernia according to GeneDecks:

(show top 50)    (show all 70)

id	Name	GO ID	Score	Top Affiliating Genes
1	diaphragm development	GO:060539	10.9	WT1, STRA6, DISP1, FGFRL1
2	embryonic digestive tract morphogenesis	GO:048557	10.9	NIPBL, SHH, FGF10, GATA4, PDGFRA, HLX
3	lung saccule development	GO:060430	10.7	NKX2-1, GATA6, FGF10
4	positive regulation of cell division	GO:051781	10.7	TGFA, SHH, GKN1, FGF2, FGF7, IGF2
5	wound healing	GO:042060	10.6	PDGFRA, FGF2, FGF10, FGF7, LOX, COL3A1
6	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.6	FGF10, FGF18, FGF2, KDR, TNF, PDGFRA
7	lung development	GO:030324	10.6	NOS3, ZFPM2, SHH, NR3C1, NKX2-1, STRA6
8	neural crest cell development	GO:014032	10.6	ALDH1A2, CYP26A1, EDN1, EDNRA
9	respiratory gaseous exchange	GO:007585	10.6	ELN, EDN1, SFTPB, EDNRA, SFTPC
10	blood vessel development	GO:001568	10.5	PAX6, MEF2C, LOX, STRA6, AGT, ALDH1A2
11	regulation of prostatic bud formation	GO:060685	10.5	AR, FGF10, SHH
12	regulation of vasoconstriction	GO:019229	10.5	EDN1, AGTR1, AGT, ACE
13	elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	GO:051482	10.5	EDNRA, AGTR1, EDN1, CALCA
14	smooth muscle cell differentiation	GO:051145	10.4	GATA6, AGT, MEF2C, FGF10
15	embryonic digestive tract development	GO:048566	10.4	ALDH1A2, RARB, TNF, STRA6
16	male genitalia morphogenesis	GO:048808	10.3	AR, FGF10, SHH
17	organ morphogenesis	GO:009887	10.3	PAX6, SLIT3, HCCS, ELN, TNF, CCL2
18	heart development	GO:007507	10.3	FBN1, MEF2C, WT1, COL3A1, SHH, MEF2A
19	Type II pneumocyte differentiation	GO:060510	10.2	FGF10, IGF1, NKX2-1, GATA6
20	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	GO:060665	10.2	FGF10, FGF7, HGF
21	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.2	CD36, CSF2, AGTR1, AGT
22	response to hyperoxia	GO:055093	10.2	NOS3, MMP9, SFTPB, SFTPC
23	maternal process involved in parturition	GO:060137	10.1	EDNRA, EDN1, CCL2
24	positive regulation of cardiac muscle cell proliferation	GO:060045	10.1	GATA6, GATA4, MEF2C, FGF2
25	negative regulation of transcription from RNA polymerase II promoter	GO:000122	10.1	SHH, VHL, SCGB1A1, EDN1, ZEB1, ZFPM2
26	blood vessel remodeling	GO:001974	10.1	IGF1, NOS3, ELN, FGF10, AGT, MEF2C
27	positive regulation of mitosis	GO:045840	10.1	IGF2, EDN1, TNF, IGF1, TGFA
28	extracellular matrix disassembly	GO:022617	10.1	MMP1, MMP13, MMP2, MMP9, ELANE, TIMP1
29	angiogenesis	GO:001525	10.0	KDR, TGFA, FGF10, MMP2, FGF18, CCL2
30	extracellular matrix organization	GO:030198	10.0	MMP13, TNF, TIMP1, MMP9, MMP2, ELANE
31	positive regulation of angiogenesis	GO:045766	9.9	F3, KDR, MMP9, GATA4, HIF1A, HMOX1
32	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.8	CCK, FGF10, IGF1, FGF7, AGT, HGF
33	positive regulation of MAPK cascade	GO:043410	9.8	AGT, IGF1, IGF2, FGF10, AR, CD36
34	male gonad development	GO:008584	9.7	RBP4, LHCGR, AR, WT1, GATA6, GATA4
35	positive regulation of transcription, DNA-dependent	GO:045893	9.7	PAX6, FGF2, FGF10, AR, CDKN1C, PAX3
36	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.6	IGF1, AGT, KDR, HGF, PDGFRA, F2
37	aging	GO:007568	9.6	F3, NR3C1, NOS3, EDNRA, AGT, TIMP1
38	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.4	FGF10, FGF2, AR, ZEB1, MEF2C, MEF2A
39	negative regulation of apoptotic process	GO:043066	9.3	ALB, KDR, AR, FGF10, GHRL, TNF
40	response to estradiol stimulus	GO:032355	9.3	NR2F2, NOS3, MMP9, SHH, PTGS2, FGF10
41	response to hypoxia	GO:001666	9.3	CCL2, MMP9, CRP, SFTPB, EDNRA, TNF
42	response to mechanical stimulus	GO:009612	9.2	F3, MMP9, CCL2, NOS3, TNF
43	positive regulation of cell proliferation	GO:008284	9.2	IGF1, AR, HLX, CSF2, TIMP1, PDGFRA
44	positive regulation of apoptotic process	GO:043065	9.2	TNF, ALDH1A2, NOS3, MMP9, RARB, AGT
45	anti-apoptosis	GO:006916	9.1	NR3C1, CCL2, IGF1, F3, GHRL, HGF
46	negative regulation of cell proliferation	GO:008285	9.1	FGF10, TIMP2, AGT, WT1, VHL, RARB
47	positive regulation of smooth muscle cell proliferation	GO:048661	9.0	ELANE, HIF1A, PTGS2, EDN1, HMOX1, IGF1
48	response to lipopolysaccharide	GO:032496	9.0	NKX2-1, SFTPB, MMP9, FGF10, F3, PTGS2
49	response to drug	GO:042493	8.7	LOX, LRP2, LHCGR, ATP4A, MMP9, CCL2
50	blood coagulation	GO:007596	8.0	ALB, F3, IGF1, MMP1, ITGA3, CD36

Molecular functions related to hernia according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	type 2 fibroblast growth factor receptor binding	GO:005111	10.5	FGF7, FGF18, FGF10
2	transcription regulatory region DNA binding	GO:044212	9.9	WT1, AR, GATA6, NKX2-1, MEF2C, TNF
3	sequence-specific DNA binding	GO:043565	9.9	HOXB5, MEF2A, AR, PAX3, ZEB1, RARB
4	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	GO:003705	9.8	GATA4, GATA6, NKX2-1, HIF1A, MEF2A, MEF2C
5	transcription factor binding	GO:008134	9.8	VHL, GATA4, GATA6, THRA, HIF1A, GNPTAB
6	sequence-specific DNA binding transcription factor activity	GO:003700	9.3	HIF1A, WT1, NR3C1, NR2F2, TEF, HOXB5
7	growth factor activity	GO:008083	9.0	AGT, FGF10, GKN1, FGF18, FGF7, IGF2
8	protein binding	GO:005515	INF	FGF2, CAMLG, CALCA, GLMN, HOXA10, TNF