MCID: HRN003
MIFTS: 45

Heroin Dependence malady

Mental diseases category
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Summaries for Heroin Dependence

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 An opiate dependence that involves the continued use of heroin despite despite problems related to use of the substance.

MalaCards: Heroin Dependence is related to personality disorder and antisocial personality disorder. An important gene associated with Heroin Dependence is ANKK1 (ankyrin repeat and kinase domain containing 1), and among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Hypothetical Network for Drug Addiction. The drugs buprenorphine and buprenorphine hydrochloride and the compounds melperone and (+)-sulpiride have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related mouse phenotype behavior/neurological.

Wikipedia:65 Opioid dependence is a medical diagnosis characterized by an individual\'s inability to stop using... more...

Aliases & Classifications for Heroin Dependence

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

heroin dependence 8 10 62


External Ids:

Disease Ontology8 DOID:9976
NCIt40 C34694
MeSH35 D006556

Related Diseases for Heroin Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Heroin Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder30.7HTR1B, DRD4, DRD2
2antisocial personality disorder30.5ANKK1, HTR1B, DRD2, GABRA6
3cocaine dependence30.1DRD2, PDYN
4schizophrenia29.9DRD2, PDYN, HTR1B, DRD4
5borderline personality disorder10.4
6hepatitis10.3
7hepatitis c10.2
8post-traumatic stress disorder10.2
9hepatitis c virus10.2
10blindness10.2
11alexithymia10.1ANKK1
12oppositional defiant disorder10.1DRD4
13neuroleptic malignant syndrome10.1DRD2
14major depressive disorder10.1
15morphine dependence10.1
16neuronitis10.1
17acquired immunodeficiency syndrome10.1
18glucagonoma10.1
19syncope10.1
20substance abuse10.0DRD2, DRD4
21delusional disorder10.0DRD4, DRD2
22pathological gambling10.0DRD4, DRD2
23conduct disorder10.0DRD4, DRD2
24hyperprolactinemia10.0DRD2, DRD4
25opiate dependence10.0DRD2, PDYN
26parkinson's disease10.0DRD2, PDYN
27nicotine dependence10.0ANKK1, DRD2, DRD4
28drug dependence10.0DRD2, PDYN
29schizoaffective disorder10.0DRD2, DRD4
30drug addiction10.0DRD2, PDYN
31attention deficit hyperactivity disorder10.0DRD2, HTR1B, DRD4
32migraine10.0HTR1B, DRD2, DRD4
33gilles de la tourette syndrome10.0DRD4, DRD2
34substance dependence10.0DRD4, DRD2, PDYN
35psychotic disorder10.0DRD2, DRD4, PDYN
36bipolar disorder9.9DRD2, PDYN, DRD4
37alzheimer's disease9.9PDYN, DRD4, DRD2
38obsessive-compulsive disorder9.9DRD4, PDYN, HTR1B, DRD2
39mood disorder9.9DRD2, HTR1B, PDYN, DRD4
40alcohol dependence9.9ANKK1, HTR1B, DRD4, DRD2, GABRA6

Graphical network of the top 20 diseases related to Heroin Dependence:



Diseases related to heroin dependence

Symptoms for Heroin Dependence

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Drugs & Therapeutics for Heroin Dependence

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Heroin Dependence

Search NIH Clinical Center for Heroin Dependence

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Heroin Dependence

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Anatomical Context for Heroin Dependence

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33MalaCards
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MalaCards organs/tissues related to Heroin Dependence:

33
Brain, Testes, Pituitary

Animal Models for Heroin Dependence or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Heroin Dependence:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.5GABRA6, DRD2, DRD4, PDYN, HTR1B

Publications for Heroin Dependence

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Sources:
52PubMed
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Articles related to Heroin Dependence:

(show top 50)    (show all 187)
idTitleAuthorsYear
1
Gender Differences Among Prisoners With Pre-Incarceration Heroin Dependence Participating in a Randomized Clinical Trial of Buprenorphine Treatment. (23997546)
2013
2
Shattered childhoods and the genetics of heroin dependence. (23496065)
2013
3
The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and borderline personality disorder in female heroin-dependent Chinese subjects. (24355137)
2013
4
Scopolamine detoxification technique for heroin dependence: a randomized trial. (24092568)
2013
5
The ADH1B and DRD2 gene polymorphism may modify the protective effect of the ALDH2 gene against heroin dependence. (23266708)
2013
6
The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects. (22138326)
2012
7
Gender differences in physical and mental health outcomes among an aging cohort of individuals with a history of heroin dependence. (22154506)
2012
8
Heroin dependence duration influences the metabolic parameters: mechanisms and consequences of impaired insulin sensitivity in hepatitis C virus seronegative heroin dependents. (23013781)
2012
9
Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction. (22015315)
2012
10
Cost-effectiveness of buprenorphine and naltrexone treatments for heroin dependence in Malaysia. (23226534)
2012
11
Association between heroin dependence and prodynorphin gene polymorphisms. (21382455)
2011
12
Heroin dependence and bloodborne virus transmission behaviors for HIV infection among newly incarcerated injection drug users in Taiwan. (20964533)
2011
13
Polymorphism G861C of 5-HT receptor subtype 1B is associated with heroin dependence in Han Chinese. (21839728)
2011
14
Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history]. (20517217)
2010
15
Long-acting injectable versus oral naltrexone maintenance therapy with psychosocial intervention for heroin dependence: a quasi-experiment. (20673549)
2010
16
Potential association of DRD2 and DAT1 genetic variation with heroin dependence. (19664686)
2009
17
Open-label dose-finding trial of buprenorphine implants (Probuphine) for treatment of heroin dependence. (19403243)
2009
18
A survey of acute and chronic heroin dependence in ten inbred mouse strains: evidence of genetic correlation with morphine dependence. (18472145)
2008
19
Maintenance treatment with buprenorphine and naltrexone for heroin dependence in Malaysia: a randomised, double-blind, placebo-controlled trial. (18586174)
2008
20
Single versus repeated sessions of ketamine-assisted psychotherapy for people with heroin dependence. (17523581)
2007
21
Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen. (17344330)
2007
22
The effect of baseline cocaine use on treatment outcomes for heroin dependence over 24 months: findings from the Australian Treatment Outcome Study. (17889301)
2007
23
A randomized trial of effectiveness and cost-effectiveness of observed versus unobserved administration of buprenorphine-naloxone for heroin dependence. (17784896)
2007
24
Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis. (17416470)
2007
25
Mental health outcomes following naltrexone implant treatment for heroin-dependence. (17229510)
2007
26
A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial. (17475739)
2007
27
Early impact of methadone induction for heroin dependence: differential effects of two dose sequences in a randomized controlled study. (16503705)
2006
28
Follow-up difficulty: correlates and relationship with outcome in heroin dependence treatment in the NEPOD study. (16243439)
2006
29
How quick to heroin dependence? (16939944)
2006
30
Heroin dependence and HIV infection in Malaysia. (16769444)
2006
31
A randomised trial of the cost effectiveness of buprenorphine as an alternative to methadone maintenance treatment for heroin dependence in a primary care setting. (15693730)
2005
32
Depression among entrants to treatment for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence, correlates and treatment seeking. (15893162)
2005
33
Naltrexone maintenance for heroin dependence: uptake, attrition and retention. (15370010)
2004
34
Studies on TCM syndrome types of heroin-dependence. (15119184)
2004
35
Adherence to heroin dependence therapies and human immunodeficiency virus/acquired immunodeficiency syndrome infection rates among drug abusers. (14648465)
2003
36
Neuroendocrine correlates of antisocial personality disorder in abstinent heroin-dependent subjects. (12745412)
2003
37
New aspects in the treatment of heroin dependence with special reference to neurobiological aspects. (12052577)
2002
38
Buprenorphine maintenance treatment of heroin dependence: the first experience from Iran. (12039619)
2002
39
Treatment of heroin dependence with buprenorphine in primary care. (12014814)
2002
40
Treatment of heroin dependence. (11177323)
2001
41
Gamma-hydroxybutyric acid in the treatment of alcohol and heroin dependence. (10869867)
2000
42
Neuroendocrine correlates of depression in abstinent heroin-dependent subjects. (11084218)
2000
43
The medical management of adolescent heroin dependence. (11123006)
2000
44
Predictors of inpatient treatment completion of subjects with heroin dependence. (21584093)
1997
45
Buprenorphine versus heroin dependence: comparison of toxicologic and psychopathologic characteristics. (8480833)
1993
46
Cocaine and heroin dependence compared in poly-drug abusers. (3354742)
1988
47
Letter: Nature of heroin dependence. (4407952)
1974
48
Heroin dependence and delinquency in women--a study of heroin addicts in Holloway prison. (5270380)
1970
49
Naloxone in heroin dependence. (5676799)
1968
50
Morbidity and mortality from heroin dependence. 3. Relation of hepatitis to self-injection techniques. (5641436)
1968

Variations for Heroin Dependence

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Expression for genes affiliated with Heroin Dependence

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heroin Dependence

Search GEO for disease gene expression data for Heroin Dependence.

Pathways for genes affiliated with Heroin Dependence

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50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 30KEGG, 55Reactome
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Pathways related to Heroin Dependence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Nicotine Activity on Dopaminergic Neurons38
9.4DRD4, DRD2
29.4DRD2, DRD4
3
Show member pathways
9.1DRD2, PDYN
4
Show member pathways
8.8DRD2, DRD4, HTR1B
5
Show member pathways
8.4HTR1B, DRD4, DRD2, GABRA6
6
Show member pathways
8.0HTR1B, PDYN, DRD4, DRD2
7
Show member pathways
7.5GABRA6, DRD2, DRD4, PDYN, HTR1B

Compounds for genes affiliated with Heroin Dependence

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 3BitterDB, 51PharmGKB, 24HMDB, 61Tocris Bioscience
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Compounds related to Heroin Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1melperone459.8DRD2, DRD4
2(+)-sulpiride299.8DRD2, DRD4
3(-)-sulpiride299.8DRD2, DRD4
4eticlopride45 2910.8DRD4, DRD2
5(+)-butaclamol45 2910.7DRD4, DRD2
6sch 23390459.7DRD2, DRD4
7remoxipride45 1110.7DRD2, DRD4
8loxapine29 45 1111.7DRD2, DRD4
9piribedil29 4510.7DRD2, DRD4
10benzamide3 4510.7DRD2, DRD4
11rotigotine29 45 1111.6DRD4, DRD2
12raclopride45 2910.6DRD4, DRD2
13fluphenazine29 45 51 1112.6DRD2, DRD4
14piperazine45 1110.5DRD2, DRD4
15nemonapride45 51 2911.5ANKK1, DRD4, DRD2
16spiperone45 2910.4DRD4, DRD2
17methylphenidate45 51 1111.4DRD4, DRD2
18ritanserin45 2910.4HTR1B, DRD2
19roxindole29 4510.3DRD2, DRD4, HTR1B
20terguride45 2910.2HTR1B, DRD4, DRD2
21antipsychotics519.2DRD2, ANKK1
22maoa459.2DRD4, HTR1B, DRD2
23ropinirole45 1110.2HTR1B, DRD2, DRD4
24lisuride45 29 1111.2DRD4, DRD2, HTR1B
25sertindole29 45 1111.2DRD2, HTR1B
26pergolide45 29 1111.2DRD4, HTR1B, DRD2
27pramipexole45 29 51 1112.2DRD4, DRD2, HTR1B
28asenapine29 1110.2DRD2, DRD4, HTR1B
29cabergoline45 29 1111.2HTR1B, DRD4, DRD2
30aripiprazole29 45 51 24 1113.2DRD4, HTR1B, DRD2
31ziprasidone29 51 45 1112.2DRD2, HTR1B, DRD4
32apomorphine29 45 1111.2HTR1B, DRD2, DRD4
33quetiapine45 51 29 24 1113.2HTR1B, DRD4, DRD2
34bromocriptine45 29 1111.2DRD4, DRD2, HTR1B
35methadone51 45 1111.1DRD2, ANKK1, PDYN
365-hydroxytryptamine459.0HTR1B, DRD2, DRD4
37sulpiride45 29 1111.0PDYN, DRD4, DRD2
38quinpirole45 2910.0DRD2, DRD4, PDYN
39heroin45 51 1111.0DRD2, DRD4, PDYN
40methamphetamine45 51 1111.0DRD2, DRD4, PDYN
416-hydroxydopamine459.0DRD2, PDYN, DRD4
42amphetamine45 51 1111.0DRD2, DRD4, PDYN
43risperidone45 51 29 61 24 1113.9DRD2, ANKK1, HTR1B, DRD4
44olanzapine45 51 29 24 1112.8ANKK1, HTR1B, DRD4, DRD2
45clozapine45 29 51 1111.8HTR1B, ANKK1, DRD2, DRD4
46nicotine45 29 51 1111.6PDYN, ANKK1, DRD4, DRD2
47gaba458.5PDYN, DRD4, GABRA6, DRD2
48levodopa45 119.4PDYN, HTR1B, DRD2, DRD4
49cocaine45 119.4PDYN, DRD4, DRD2, HTR1B
50dopamine45 29 24 1111.3DRD4, DRD2, HTR1B, PDYN

GO Terms for genes affiliated with Heroin Dependence

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16Gene Ontology
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Cellular components related to Heroin Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:0431979.4DRD2, DRD4
2integral component of plasma membraneGO:0058878.3GABRA6, HTR1B, DRD4, DRD2
3plasma membraneGO:0058867.2GABRA6, HTR1B, PDYN, DRD4, DRD2

Biological processes related to Heroin Dependence according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:0347769.7DRD2, DRD4
2positive regulation of dopamine uptake involved in synaptic transmissionGO:0515869.7DRD2, DRD4
3adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.7DRD2, DRD4
4negative regulation of voltage-gated calcium channel activityGO:19013869.7DRD2, DRD4
5behavioral response to ethanolGO:0481499.7DRD4, DRD2
6dopamine metabolic processGO:0424179.7DRD2, DRD4
7negative regulation of protein secretionGO:0507099.7DRD4, DRD2
8synaptic transmission, dopaminergicGO:0019639.6DRD4, DRD2
9negative regulation of synaptic transmission, glutamatergicGO:0519679.6DRD2, HTR1B
10behavioral response to cocaineGO:0481489.5DRD2, DRD4
11negative regulation of cAMP biosynthetic processGO:0308189.5HTR1B, DRD4
12G-protein coupled receptor internalizationGO:0020319.5HTR1B, DRD2
13arachidonic acid secretionGO:0504829.5DRD2, DRD4
14cellular calcium ion homeostasisGO:0068749.4DRD2, DRD4
15response to cocaineGO:0422209.3HTR1B, DRD2
16negative regulation of adenylate cyclase activityGO:0071949.3DRD2, DRD4
17response to amphetamineGO:0019759.1DRD2, DRD4

Molecular functions related to Heroin Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel regulator activityGO:0154599.4DRD2, DRD4
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.3DRD2, DRD4
3dopamine bindingGO:0352409.1DRD2, DRD4
4drug bindingGO:0081448.8DRD2, DRD4, HTR1B

Products for genes affiliated with Heroin Dependence

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  • Antibodies
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Sources for Heroin Dependence

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet