MCID: HRN003
MIFTS: 46

Heroin Dependence malady

Mental diseases category
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Summaries for Heroin Dependence

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Disease Ontology:8 An opiate dependence that involves the continued use of heroin despite despite problems related to use of the substance.

MalaCards based summary: Heroin Dependence is related to personality disorder and antisocial personality disorder. An important gene associated with Heroin Dependence is ANKK1 (ankyrin repeat and kinase domain containing 1), and among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Hypothetical Network for Drug Addiction. The drugs buprenorphine and buprenorphine hydrochloride and the compounds (-)-sulpiride and (+)-sulpiride have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related mouse phenotype behavior/neurological.

Wikipedia:65 Opioid dependence is a medical diagnosis characterized by an individual\'s inability to stop using... more...

Aliases & Classifications for Heroin Dependence

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Heroin Dependence, Aliases & Descriptions:

Name: Heroin Dependence 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:9976
NCIt39 C34694
MeSH34 D006556

Related Diseases for Heroin Dependence

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Diseases related to Heroin Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder30.7HTR1B, DRD4, DRD2
2antisocial personality disorder30.2GABRA6, DRD2, HTR1B, ANKK1
3cocaine dependence30.0DRD2, PDYN
4schizophrenia29.6HTR1B, PDYN, DRD4, DRD2
5hepatitis10.4
6borderline personality disorder10.4
7alexithymia10.4ANKK1
8oppositional defiant disorder10.4DRD4
9neuroleptic malignant syndrome10.3DRD2
10post-traumatic stress disorder10.2
11hepatitis c10.2
12hepatitis c virus10.2
13blindness10.2
14substance abuse10.2DRD2, DRD4
15delusional disorder10.1DRD2, DRD4
16pathological gambling10.1DRD4, DRD2
17conduct disorder10.1DRD2, DRD4
18hepatitis b10.1
19major depressive disorder10.1
20morphine dependence10.1
21neuronitis10.1
22glucagonoma10.1
23syncope10.1
24hyperprolactinemia10.0DRD2, DRD4
25opiate dependence10.0PDYN, DRD2
26parkinson's disease10.0DRD2, PDYN
27nicotine dependence10.0ANKK1, DRD4, DRD2
28drug dependence10.0DRD2, PDYN
29schizoaffective disorder10.0DRD4, DRD2
30drug addiction9.9PDYN, DRD2
31attention deficit hyperactivity disorder9.9HTR1B, DRD4, DRD2
32migraine9.9DRD2, DRD4, HTR1B
33gilles de la tourette syndrome9.9DRD2, DRD4
34substance dependence9.8DRD2, DRD4, PDYN
35psychotic disorder9.8DRD2, DRD4, PDYN
36bipolar disorder9.8PDYN, DRD4, DRD2
37alzheimer's disease9.7DRD2, DRD4, PDYN
38obsessive-compulsive disorder9.6HTR1B, PDYN, DRD4, DRD2
39mood disorder9.6DRD2, DRD4, PDYN, HTR1B
40alcohol dependence9.5GABRA6, ANKK1, HTR1B, DRD4, DRD2

Graphical network of the top 20 diseases related to Heroin Dependence:



Diseases related to heroin dependence

Symptoms for Heroin Dependence

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Drugs & Therapeutics for Heroin Dependence

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Drug clinical trials:

Search ClinicalTrials for Heroin Dependence

Search NIH Clinical Center for Heroin Dependence

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Heroin Dependence

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Anatomical Context for Heroin Dependence

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MalaCards organs/tissues related to Heroin Dependence:

32
Brain, Testes, Pituitary

Animal Models for Heroin Dependence or affiliated genes

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MGI Mouse Phenotypes related to Heroin Dependence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.5GABRA6, DRD2, DRD4, PDYN, HTR1B

Publications for Heroin Dependence

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Articles related to Heroin Dependence:

(show top 50)    (show all 195)
idTitleAuthorsYear
1
Chronic heroin dependence leading to adrenal insufficiency. (25221675)
2014
2
Comparative study of the perceived quality of life of patients in treatment for cocaine and heroin dependence in Spain: differences by gender and time in treatment. (24712297)
2014
3
Gender Differences Among Prisoners With Pre-Incarceration Heroin Dependence Participating in a Randomized Clinical Trial of Buprenorphine Treatment. (23997546)
2013
4
Shattered childhoods and the genetics of heroin dependence. (23496065)
2013
5
Case-control study of error-related negativity among males with heroin dependence undergoing rehabilitation. (24991149)
2013
6
The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and borderline personality disorder in female heroin-dependent Chinese subjects. (24355137)
2013
7
Scopolamine detoxification technique for heroin dependence: a randomized trial. (24092568)
2013
8
The ADH1B and DRD2 gene polymorphism may modify the protective effect of the ALDH2 gene against heroin dependence. (23266708)
2013
9
The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects. (22138326)
2012
10
Gender differences in physical and mental health outcomes among an aging cohort of individuals with a history of heroin dependence. (22154506)
2012
11
Heroin dependence duration influences the metabolic parameters: mechanisms and consequences of impaired insulin sensitivity in hepatitis C virus seronegative heroin dependents. (23013781)
2012
12
Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction. (22015315)
2012
13
Cost-effectiveness of buprenorphine and naltrexone treatments for heroin dependence in Malaysia. (23226534)
2012
14
Association between heroin dependence and prodynorphin gene polymorphisms. (21382455)
2011
15
Heroin dependence and bloodborne virus transmission behaviors for HIV infection among newly incarcerated injection drug users in Taiwan. (20964533)
2011
16
Polymorphism G861C of 5-HT receptor subtype 1B is associated with heroin dependence in Han Chinese. (21839728)
2011
17
Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history]. (20517217)
2010
18
Long-acting injectable versus oral naltrexone maintenance therapy with psychosocial intervention for heroin dependence: a quasi-experiment. (20673549)
2010
19
Potential association of DRD2 and DAT1 genetic variation with heroin dependence. (19664686)
2009
20
Open-label dose-finding trial of buprenorphine implants (Probuphine) for treatment of heroin dependence. (19403243)
2009
21
A survey of acute and chronic heroin dependence in ten inbred mouse strains: evidence of genetic correlation with morphine dependence. (18472145)
2008
22
Maintenance treatment with buprenorphine and naltrexone for heroin dependence in Malaysia: a randomised, double-blind, placebo-controlled trial. (18586174)
2008
23
Disrupted white matter integrity in heroin dependence: a controlled study utilizing diffusion tensor imaging. (18720268)
2008
24
Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen. (17344330)
2007
25
The effect of baseline cocaine use on treatment outcomes for heroin dependence over 24 months: findings from the Australian Treatment Outcome Study. (17889301)
2007
26
A randomized trial of effectiveness and cost-effectiveness of observed versus unobserved administration of buprenorphine-naloxone for heroin dependence. (17784896)
2007
27
Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis. (17416470)
2007
28
Mental health outcomes following naltrexone implant treatment for heroin-dependence. (17229510)
2007
29
How quick to heroin dependence? (16939944)
2006
30
Heroin dependence and HIV infection in Malaysia. (16769444)
2006
31
A randomised trial of the cost effectiveness of buprenorphine as an alternative to methadone maintenance treatment for heroin dependence in a primary care setting. (15693730)
2005
32
Depression among entrants to treatment for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence, correlates and treatment seeking. (15893162)
2005
33
Naltrexone maintenance for heroin dependence: uptake, attrition and retention. (15370010)
2004
34
Studies on TCM syndrome types of heroin-dependence. (15119184)
2004
35
Neuroendocrine correlates of antisocial personality disorder in abstinent heroin-dependent subjects. (12745412)
2003
36
New aspects in the treatment of heroin dependence with special reference to neurobiological aspects. (12052577)
2002
37
Buprenorphine maintenance treatment of heroin dependence: the first experience from Iran. (12039619)
2002
38
Treatment of heroin dependence with buprenorphine in primary care. (12014814)
2002
39
Treatment of heroin dependence. (11177323)
2001
40
Treatment of heroin dependence. (11304111)
2001
41
Gamma-hydroxybutyric acid in the treatment of alcohol and heroin dependence. (10869867)
2000
42
Neuroendocrine correlates of depression in abstinent heroin-dependent subjects. (11084218)
2000
43
The medical management of adolescent heroin dependence. (11123006)
2000
44
Predictors of inpatient treatment completion of subjects with heroin dependence. (21584093)
1997
45
Buprenorphine versus heroin dependence: comparison of toxicologic and psychopathologic characteristics. (8480833)
1993
46
Cocaine and heroin dependence compared in poly-drug abusers. (3354742)
1988
47
Letter: Nature of heroin dependence. (4407952)
1974
48
Heroin dependence and delinquency in women--a study of heroin addicts in Holloway prison. (5270380)
1970
49
Naloxone in heroin dependence. (5676799)
1968
50
Morbidity and mortality from heroin dependence. 3. Relation of hepatitis to self-injection techniques. (5641436)
1968

Variations for Heroin Dependence

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Expression for genes affiliated with Heroin Dependence

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Expression patterns in normal tissues for genes affiliated with Heroin Dependence

Search GEO for disease gene expression data for Heroin Dependence.

Pathways for genes affiliated with Heroin Dependence

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Pathways related to Heroin Dependence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Nicotine Activity on Dopaminergic Neurons37
9.4DRD4, DRD2
29.4DRD2, DRD4
3
Show member pathways
9.1DRD2, PDYN
4
Show member pathways
8.8DRD2, DRD4, HTR1B
5
Show member pathways
8.4HTR1B, DRD4, DRD2, GABRA6
6
Show member pathways
8.0HTR1B, PDYN, DRD4, DRD2
7
Show member pathways
7.5GABRA6, DRD2, DRD4, PDYN, HTR1B

Compounds for genes affiliated with Heroin Dependence

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Compounds related to Heroin Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1(-)-sulpiride289.8DRD4, DRD2
2(+)-sulpiride289.8DRD4, DRD2
3melperone449.8DRD4, DRD2
4eticlopride44 2810.8DRD2, DRD4
5sch 23390449.7DRD2, DRD4
6(+)-butaclamol44 2810.7DRD2, DRD4
7remoxipride44 1110.7DRD4, DRD2
8loxapine28 44 1111.7DRD4, DRD2
9piribedil28 4410.7DRD2, DRD4
10benzamide2 4410.7DRD2, DRD4
11rotigotine28 44 1111.6DRD4, DRD2
12raclopride44 2810.6DRD4, DRD2
13fluphenazine28 44 50 1112.6DRD2, DRD4
14antipsychotics509.5DRD2, ANKK1
15spiperone44 2810.5DRD4, DRD2
16nemonapride44 50 2811.5DRD2, DRD4, ANKK1
17ritanserin44 2810.4HTR1B, DRD2
18piperazine44 1110.4DRD4, DRD2
19methylphenidate44 50 1111.3DRD2, DRD4
20roxindole28 4410.3DRD2, DRD4, HTR1B
21terguride44 2810.2DRD2, DRD4, HTR1B
22ropinirole44 1110.2HTR1B, DRD4, DRD2
23maoa449.2HTR1B, DRD4, DRD2
24lisuride44 28 1111.2DRD2, DRD4, HTR1B
25pergolide44 28 1111.2HTR1B, DRD4, DRD2
26pramipexole44 28 50 1112.2DRD2, DRD4, HTR1B
27asenapine28 1110.2HTR1B, DRD4, DRD2
28cabergoline44 28 1111.2DRD2, DRD4, HTR1B
29aripiprazole28 44 50 24 1113.2DRD2, DRD4, HTR1B
30ziprasidone28 50 44 1112.2HTR1B, DRD4, DRD2
31apomorphine28 44 1111.2HTR1B, DRD4, DRD2
32quetiapine44 50 28 24 1113.2DRD2, DRD4, HTR1B
33bromocriptine44 28 1111.2DRD2, DRD4, HTR1B
34methadone50 44 1111.1DRD2, PDYN, ANKK1
355-hydroxytryptamine449.0HTR1B, DRD4, DRD2
36sulpiride44 28 1111.0PDYN, DRD4, DRD2
37sertindole28 44 1111.0DRD2, HTR1B
38quinpirole44 2810.0DRD2, DRD4, PDYN
39heroin44 50 1111.0PDYN, DRD4, DRD2
40methamphetamine44 50 1111.0PDYN, DRD4, DRD2
416-hydroxydopamine449.0DRD2, DRD4, PDYN
42amphetamine44 50 1111.0PDYN, DRD4, DRD2
43risperidone44 50 28 61 24 1113.9DRD2, DRD4, HTR1B, ANKK1
44olanzapine44 50 28 24 1112.8ANKK1, HTR1B, DRD4, DRD2
45clozapine44 28 50 1111.8ANKK1, HTR1B, DRD4, DRD2
46nicotine44 28 50 1111.6DRD2, DRD4, PDYN, ANKK1
47gaba448.5GABRA6, DRD2, DRD4, PDYN
48levodopa44 119.4DRD2, DRD4, PDYN, HTR1B
49cocaine44 119.4DRD2, DRD4, PDYN, HTR1B
50dopamine44 28 24 1111.3HTR1B, PDYN, DRD4, DRD2

GO Terms for genes affiliated with Heroin Dependence

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Cellular components related to Heroin Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:0431979.4DRD2, DRD4
2integral component of plasma membraneGO:0058878.3GABRA6, HTR1B, DRD4, DRD2
3plasma membraneGO:0058867.2GABRA6, HTR1B, PDYN, DRD4, DRD2

Biological processes related to Heroin Dependence according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:0347769.7DRD4, DRD2
2positive regulation of dopamine uptake involved in synaptic transmissionGO:0515869.7DRD4, DRD2
3negative regulation of voltage-gated calcium channel activityGO:19013869.7DRD4, DRD2
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.7DRD4, DRD2
5behavioral response to ethanolGO:0481499.7DRD2, DRD4
6dopamine metabolic processGO:0424179.7DRD4, DRD2
7negative regulation of protein secretionGO:0507099.7DRD2, DRD4
8synaptic transmission, dopaminergicGO:0019639.6DRD2, DRD4
9negative regulation of synaptic transmission, glutamatergicGO:0519679.6DRD2, HTR1B
10behavioral response to cocaineGO:0481489.5DRD2, DRD4
11negative regulation of cAMP biosynthetic processGO:0308189.5HTR1B, DRD4
12arachidonic acid secretionGO:0504829.5DRD4, DRD2
13G-protein coupled receptor internalizationGO:0020319.5DRD2, HTR1B
14cellular calcium ion homeostasisGO:0068749.4DRD4, DRD2
15negative regulation of adenylate cyclase activityGO:0071949.3DRD2, DRD4
16response to cocaineGO:0422209.3DRD2, HTR1B
17response to amphetamineGO:0019759.1DRD4, DRD2

Molecular functions related to Heroin Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel regulator activityGO:0154599.4DRD2, DRD4
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.3DRD2, DRD4
3dopamine bindingGO:0352409.1DRD2, DRD4
4drug bindingGO:0081448.8DRD2, DRD4, HTR1B

Products for genes affiliated with Heroin Dependence

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Sources for Heroin Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet