MCID: HRN003
MIFTS: 50

Heroin Dependence malady

Summaries for Heroin Dependence

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An opiate dependence that involves the continued use of heroin despite despite problems related to use of the substance.

MalaCards: Heroin Dependence is related to cocaine dependence and alcohol dependence. An important gene associated with Heroin Dependence is GABRA6 (gamma-aminobutyric acid (GABA) A receptor, alpha 6), and among its related pathways are Benzodiazepine Pathway, Pharmacodynamics and Dopamine receptors. The drugs buprenorphine and buprenorphine hydrochloride and the compounds p-chloroamphetamine and MMDA have been mentioned in the context of this disorder. Affiliated tissues include brain and pituitary, and related mouse phenotypes are normal and no phenotypic analysis.

Wikipedia:64 Opioid dependence is a medical diagnosis characterized by an individual\'s inability to stop using... more...

Aliases & Classifications for Heroin Dependence

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

heroin dependence 8 10 61


External Ids:

Disease Ontology8 DOID:9976
NCIt40 C34694
MeSH35 D006556

Related Diseases for Heroin Dependence

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Heroin Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1cocaine dependence30.6PDYN, DRD2, OPRM1, SLC6A3, SLC6A4
2alcohol dependence30.6DRD4, GABRA6, OPRM1, ANKK1, MAOA, SLC6A4
3borderline personality disorder30.5HTR1B, MAOA, SLC6A4
4antisocial personality disorder30.5HTR1B, DRD2, GABRA6, ANKK1, MAOA, SLC6A3
5substance dependence30.3DRD2, DRD4, OPRM1, SLC6A3, SLC6A4, PDYN
6cocaine abuse30.1DRD2, SLC6A3, SLC6A4
7alcohol abuse30.0SLC6A4, SLC6A3, OPRM1, DRD2, COMT
8dependent personality disorder10.4
9hepatitis d10.3
10hepatitis c10.2
11post-traumatic stress disorder10.2
12hepatitis c virus10.2
13morphine dependence10.1
14major depressive disorder10.1
15acquired immunodeficiency syndrome10.1
16glucagonoma10.1
17syncope10.1
18alexithymia10.0ANKK1
19restless legs syndrome10.0DRD2
20opiate dependence10.0OPRM1
21hypertension10.0SLC6A4
22premature ejaculation10.0SLC6A4
23paranoid schizophrenia10.0COMT
24essential tremor10.0SLC6A3
25hepatic encephalopathy10.0MAOA
26alcoholic psychosis10.0SLC6A4
27fragile x syndrome10.0SLC6A4
28neuroblastoma10.0SLC6A2, OPRM1
29attention deficit hyperactivity disorder10.0SLC6A3, DRD4
30fibromyalgia10.0SLC6A4, COMT
31melancholia10.0MAOA
32seasonal affective disorder10.0SLC6A4, DRD4
33constipation10.0OPRM1, SLC6A4
34myoclonus-dystonia10.0DRD2
35chronic fatigue syndrome10.0SLC6A4, MAOA
36narcolepsy10.0DRD2, COMT
37delusional disorder10.0DRD4, DRD2
38pathological gambling10.0DRD2, DRD4, SLC6A3
39withdrawal disorder10.0PDYN, OPRM1
40gilles de la tourette syndrome10.0DRD2, DRD4, SLC6A3
41huntington's disease10.0DRD2
42striatonigral degeneration10.0SLC6A3, DRD2
43wilson disease10.0SLC6A3, DRD2
44juvenile myoclonic epilepsy10.0GABRA1, GABRG2
45focal epilepsy10.0PDYN, GABRG2
46irritable bowel syndrome10.0SLC6A4
47bipolar disorder10.0SLC6A4, DRD2
48endogenous depression10.0SLC6A4, GAD1
49amnestic disorder10.0PDYN, GAD1, OPRM1
50cholera10.0GAD1, SLC6A4

Graphical network of the top 20 diseases related to Heroin Dependence:



Diseases related to heroin dependence

Clinical Features for Heroin Dependence

Drugs & Therapeutics for Heroin Dependence

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Heroin Dependence

Drug clinical trials:

Search ClinicalTrials for Heroin Dependence

Search NIH Clinical Center for Heroin Dependence

Search CenterWatch for Heroin Dependence

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Heroin Dependence

Anatomical Context for Heroin Dependence

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Heroin Dependence:

33
Brain, Pituitary

Animal Models for Heroin Dependence or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Heroin Dependence

Sources:
51PubMed
See all sources

Articles related to Heroin Dependence:

(show top 50)    (show all 198)
idTitleAuthorsYear
1
DRD3 variation associates with early-onset heroin dependence, but not specific personality traits. (24398431)
2014
2
Association of OPRD1 polymorphisms with heroin dependence in a large case-control series. (22500942)
2014
3
Shattered childhoods and the genetics of heroin dependence. (23496065)
2013
4
White matter impairment in chronic heroin dependence: a quantitative DTI study. (23895765)
2013
5
Association of the GDNF gene with depression and heroin dependence, but not schizophrenia, in a Chinese population. (24022000)
2013
6
Heroin dependence duration influences the metabolic parameters: mechanisms and consequences of impaired insulin sensitivity in hepatitis C virus seronegative heroin dependents. (23013781)
2012
7
Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction. (22015315)
2012
8
The aldehyde dehydrogenase 2 gene is associated with heroin dependence. (21723677)
2012
9
Former heroin addicts with or without a history of cocaine dependence are more impulsive than controls. (22265192)
2012
10
Association between heroin dependence and prodynorphin gene polymorphisms. (21382455)
2011
11
Long-acting depot formulations of naltrexone for heroin dependence: a review. (20224403)
2010
12
Open-label dose-finding trial of buprenorphine implants (Probuphine) for treatment of heroin dependence. (19403243)
2009
13
The role of genetic variants of the dopaminergic system in heroin dependence]. (19827317)
2009
14
Disrupted white matter integrity in heroin dependence: a controlled study utilizing diffusion tensor imaging. (18720268)
2008
15
Impact of substance dependence and dual diagnosis on the quality of life of heroin users seeking treatment. (18393080)
2008
16
A randomized trial of effectiveness and cost-effectiveness of observed versus unobserved administration of buprenorphine-naloxone for heroin dependence. (17784896)
2007
17
Differential regional effects of methadone maintenance compared to heroin dependence on mu-opioid receptor desensitization in rat brain. (17152089)
2007
18
The Australian Treatment Outcome Study (ATOS): what have we learnt about treatment for heroin dependence? (17364836)
2007
19
Borderline personality disorder and persistently elevated levels of risk in 36-month outcomes for the treatment of heroin dependence. (17567402)
2007
20
Pathways into receiving a prescription for diamorphine (heroin) for the treatment of opiate dependence in the United kingdom. (17570910)
2007
21
Reliability of self-reported trauma exposure among people with heroin dependence: a longitudinal investigation. (17598137)
2007
22
Early impact of methadone induction for heroin dependence: differential effects of two dose sequences in a randomized controlled study. (16503705)
2006
23
How quick to heroin dependence? (16939944)
2006
24
Glucocorticoid negative feedback in methadone-maintained former heroin addicts with ongoing cocaine dependence: dose-response to dexamethasone suppression. (16759341)
2006
25
Genome-wide linkage analysis of heroin dependence in Han Chinese: results from wave one of a multi-stage study. (16856125)
2006
26
Patterns and costs of treatment for heroin dependence over 12 months: findings from the Australian Treatment Outcome Study. (16956156)
2006
27
Unlimited access to heroin self-administration: independent motivational markers of opiate dependence. (16452993)
2006
28
Naltrexone implants as treatment for heroin dependence: part II. (16201030)
2005
29
Combined effect of promoter polymorphisms in the dopamine D4 receptor and the serotonin transporter genes in heroin dependence. (16167465)
2005
30
Naltrexone implants as treatment for heroin dependence: part I. (16191674)
2005
31
Adverse events among patients in a behavioral treatment trial for heroin and cocaine dependence: effects of age, race, and gender. (16157230)
2005
32
Naltrexone maintenance for heroin dependence: uptake, attrition and retention. (15370010)
2004
33
Agonist-like or antagonist-like treatment for cocaine dependence with methadone for heroin dependence: two double-blind randomized clinical trials. (15039761)
2004
34
1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial. (12606177)
2003
35
New aspects in the treatment of heroin dependence with special reference to neurobiological aspects. (12052577)
2002
36
Treatment of heroin dependence. (11304111)
2001
37
Buprenorphine and naloxone for heroin dependence. (11123005)
2000
38
Selective cognitive processing of drug cues in heroin dependence. (11198058)
2000
39
Evidence for an association between heroin dependence and a VNTR polymorphism at the serotonin transporter locus. (10395208)
1999
40
Buprenorphine treatment for concurrent heroin and cocaine dependence: phase I study. (1875999)
1990
41
The 1985 Dent memorial lecture. 'I need heroin'. Thirty years' experience of drug dependence and of the medical challenges at local, national, international and political level. What next? (3530292)
1986
42
Buprenorphine as new treatment for heroin dependence. (4092611)
1985
43
Heroin dependence in developing countries: WHO collaborates in treatment evaluation studies. (6445134)
1980
44
Notes on Alcoholism and Drug Abuse: Propoxyphene-Napsylate (Darvon-N or PN) in the Treatment of Heroin Dependence. (18747998)
1977
45
Methadone treatment of heroin dependence. (4450082)
1974
46
Current issues in methadone treatment of heroin dependence. (5123755)
1971
47
Treatment of heroin dependence with opiate antagonists. (5507440)
1970
48
Naloxone in heroin dependence. (5676799)
1968
49
Heroin dependence in Britain and the U.S.A. (5648301)
1968
50
Morbidity and mortality from heroin dependence. 2. Study of 100 consecutive inpatients. (5641435)
1968

Genetic Variations for Heroin Dependence

Expression for genes affiliated with Heroin Dependence

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Heroin Dependence

Search GEO for disease gene expression data for Heroin Dependence.

Pathways for genes affiliated with Heroin Dependence

Sources:
50PharmGKB, 54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 53R&D Systems
See all sources

Pathways related to Heroin Dependence according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2GABRG2, GABRA1
210.2DRD4, DRD2
3
Hide members
10.2SLC6A3, MAOA
4
Hide members
10.2SLC6A2, SLC6A4
5
Hide members
10.2MAOA, COMT
6
Hide members
10.1GABRA6, GABRA1, GABRG2
710.1GABRA6, GABRA1, GABRG2
810.0SLC6A2, SLC6A4, SLC6A3
99.9HTR3B, GABRA6, GABRA1, GABRG2
109.9PDYN, DRD2, MAOA, SLC6A3
11
Hide members
9.9PDYN, DRD2, MAOA, SLC6A3
12
Hide members
9.8HTR1B, DRD2, DRD4, MAOA, SLC6A4
13
Hide members
9.7HTR3B, GAD1, GABRA6, GABRA1, GABRG2
14
Hide members
9.7HTR3B, GABRA6, GABRA1, GABRG2, SLC6A3, SLC6A2
15
Hide members
9.5PDYN, HTR1B, DRD2, DRD4, GABRA6, GABRA1
16
Hide members
9.5COMT, GAD1, GABRA6, GABRA1, GABRG2, MAOA
17
Hide members
8.5PER3, COMT, HTR1B, HTR3B, DRD2, DRD4

Compounds for genes affiliated with Heroin Dependence

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Heroin Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 252)
idCompoundScoreTop Affiliating Genes
1p-chloroamphetamine4510.2MAOA, SLC6A3, SLC6A4, SLC6A2
2MMDA1110.2SLC6A3, SLC6A4, SLC6A2, MAOA
3phentermine45 1111.2MAOA, SLC6A3, SLC6A4, SLC6A2
4piperazine45 1111.2DRD2, SLC6A2, SLC6A3, OPRM1, DRD4
5sulpiride45 29 1112.2DRD4, DRD2, PDYN, SLC6A3
6pseudoephedrine45 11 2412.2SLC6A2, SLC6A4, SLC6A3, MAOA
7venlafaxine50 45 11 2413.2SLC6A4, SLC6A2, HTR1B, GABRA6, SLC6A3
8pramipexole45 50 29 1113.2COMT, HTR1B, DRD2, DRD4, SLC6A3
9mdma4510.2MAOA, SLC6A2, SLC6A4, SLC6A3
10Ephedra1110.2MAOA, SLC6A3, SLC6A4, SLC6A2
11amoxapine45 29 1112.2DRD2, SLC6A4, SLC6A2, GABRA1
12d amphetamine4510.1DRD2, MAOA, SLC6A3, SLC6A4, SLC6A2
13mhpg4510.1SLC6A2, SLC6A4, MAOA, DRD4, COMT
14apomorphine45 29 1112.1SLC6A3, DRD4, COMT, HTR1B, DRD2
15maprotiline45 1111.1SLC6A3, SLC6A4, SLC6A2, MAOA
16ropinirole45 1111.1DRD4, DRD2, HTR1B, COMT
17trimipramine50 45 1112.1SLC6A2, DRD2, SLC6A3, SLC6A4
18olanzapine50 45 29 11 2414.1DRD4, ANKK1, SLC6A3, COMT, DRD2, HTR1B
19bromocriptine29 45 1112.1SLC6A3, DRD4, DRD2, HTR1B, COMT
20bupropion45 50 11 2413.0COMT, DRD2, ANKK1, SLC6A2, SLC6A4, SLC6A3
21tyramine45 29 2412.0SLC6A2, SLC6A4, SLC6A3, MAOA, OPRM1, COMT
22pergolide29 45 1112.0DRD4, HTR1B, COMT, DRD2
23homovanillic acid45 2411.0SLC6A2, MAOA, SLC6A4, COMT
24sertraline45 29 50 11 2414.0MAOA, SLC6A3, SLC6A4, SLC6A2
25fluoxetine50 45 29 1113.0DRD2, HTR1B, MAOA, SLC6A3, SLC6A4, SLC6A2
26heroin45 50 1112.0SLC6A4, COMT, DRD4, DRD2, PDYN, OPRM1
27risperidone29 45 50 60 11 2415.0SLC6A3, ANKK1, SLC6A4, DRD4, DRD2, COMT
28phencyclidine45 29 1112.0SLC6A3, DRD2, OPRM1, DRD4
29nmda45 2911.0COMT, GAD1, PDYN, OPRM1, MAOA, SLC6A3
30paroxetine45 50 29 1112.9HTR1B, SLC6A3, MAOA, DRD4, SLC6A4, SLC6A2
31methylphenidate45 50 1111.9COMT, DRD2, DRD4, MAOA, SLC6A3, SLC6A4
32amphetamine45 1110.9DRD2, DRD4, MAOA, PDYN, SLC6A3, SLC6A4
33haloperidol45 29 2 50 1113.9DRD2, SLC6A2, SLC6A3, OPRM1, GAD1, SLC6A4
346-hydroxydopamine459.8SLC6A2, SLC6A3, MAOA, OPRM1, DRD4, DRD2
35mptp459.8SLC6A2, SLC6A3, MAOA, GAD1, DRD2, COMT
36opiate459.8OPRM1, SLC6A4, SLC6A3, PDYN, DRD2
37maoa459.8DRD2, HTR1B, COMT, DRD4, MAOA, SLC6A3
381 methyl 4 phenylpyridinium459.8SLC6A4, SLC6A2, SLC6A3, MAOA
39clozapine45 29 50 1112.8COMT, HTR1B, DRD2, DRD4, SLC6A3, GAD1
40epinephrine45 11 2411.7PDYN, SLC6A4, MAOA, OPRM1, COMT, SLC6A2
41cocaine45 1110.7HTR1B, OPRM1, SLC6A3, COMT, PDYN, DRD2
42levodopa45 1110.7SLC6A3, MAOA, OPRM1, GAD1, DRD4, DRD2
43norepinephrine45 11 2411.6PDYN, DRD2, COMT, DRD4, OPRM1, SLC6A3
44fluvoxamine45 50 1111.6MAOA, SLC6A2, SLC6A4, SLC6A3
45nicotine45 50 29 1112.5COMT, PDYN, DRD2, OPRM1, ANKK1, MAOA
46methamphetamine45 50 1111.5SLC6A2, SLC6A4, SLC6A3, MAOA, OPRM1, GABRG2
475-hydroxytryptamine459.5DRD4, DRD2, HTR3B, HTR1B, COMT, OPRM1
48glutamate459.4SLC6A3, SLC6A4, SLC6A2, MAOA, OPRM1, GAD1
49dopamine45 29 11 2412.3COMT, SLC6A2, MAOA, OPRM1, GAD1, DRD4
50gaba459.3DRD2, DRD4, GAD1, SLC6A2, SLC6A4, SLC6A3

GO Terms for genes affiliated with Heroin Dependence

Sources:
16Gene Ontology
See all sources

Cellular components related to Heroin Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vesicle membraneGO:01250610.2GAD1, DRD4
2chloride channel complexGO:03470710.0GABRA6, GABRA1, GABRG2
3postsynaptic membraneGO:0452119.6GABRG2, GABRA1, GABRA6, HTR3B
4integral to plasma membraneGO:0058879.1SLC6A2, HTR1B, HTR3B, DRD2, DRD4, GABRA6
5plasma membraneGO:0058868.5DRD4, DRD2, HTR3B, HTR1B, PDYN, COMT

Biological processes related to Heroin Dependence according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of voltage-gated calcium channel activityGO:190138610.6DRD2, DRD4
2synaptic transmission, GABAergicGO:05193210.6GABRA1, GABRG2
3positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.6DRD2, DRD4
4response to histamineGO:03477610.6DRD2, DRD4
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD4, DRD2
6regulation of dopamine metabolic processGO:04205310.5SLC6A3, DRD4
7reduction of cytosolic calcium ion concentrationGO:05148110.5DRD2, OPRM1
8adenohypophysis developmentGO:02198410.5DRD2, SLC6A3
9negative regulation of cAMP biosynthetic processGO:03081810.5HTR1B, DRD4
10gamma-aminobutyric acid signaling pathwayGO:00721410.5GABRG2, GABRA1, GABRA6
11negative regulation of synaptic transmission, glutamatergicGO:05196710.5DRD2, HTR1B
12behavioral response to ethanolGO:04814910.5OPRM1, DRD4, DRD2
13neurotransmitter catabolic processGO:04213510.5COMT, MAOA
14dopamine metabolic processGO:04241710.5DRD2, DRD4
15negative regulation of adenylate cyclase activityGO:00719410.5OPRM1, DRD4, DRD2
16response to cocaineGO:04222010.5HTR1B, DRD2, SLC6A3
17regulation of behaviorGO:05079510.5HTR1B, OPRM1
18monoamine transportGO:01584410.5SLC6A3, SLC6A4, SLC6A2
19regulation of dopamine secretionGO:01405910.4HTR1B, DRD2
20dopamine catabolic processGO:04242010.4SLC6A3, MAOA, COMT
21negative regulation of protein secretionGO:05070910.4DRD2, DRD4
22behavioral response to cocaineGO:04814810.4DRD2, DRD4
23locomotory behaviorGO:00762610.4DRD2, OPRM1, SLC6A3
24response to iron ionGO:01003910.3DRD2, SLC6A3
25G-protein coupled receptor internalizationGO:00203110.3HTR1B, DRD2
26ion transmembrane transportGO:03422010.3HTR3B, GABRA6, GABRA1, GABRG2
27synaptic transmission, dopaminergicGO:00196310.3DRD2, DRD4
28neurotransmitter biosynthetic processGO:04213610.3COMT, GAD1, MAOA, SLC6A3
29prepulse inhibitionGO:06013410.2DRD2, SLC6A3
30response to painGO:04826510.2SLC6A2, COMT
31arachidonic acid secretionGO:05048210.1DRD4, DRD2
32response to drugGO:04249310.1COMT, DRD2, GAD1, SLC6A3, SLC6A4
33transportGO:00681010.1HTR3B, GABRA6, GABRA1, GABRG2, SLC6A3, SLC6A2
34transmembrane transportGO:05508510.0HTR3B, GABRA6, GABRA1, GABRG2, SLC6A3, SLC6A2
35vasoconstrictionGO:0423109.9SLC6A4, HTR1B
36synaptic transmissionGO:0072689.3SLC6A2, COMT, PDYN, HTR1B, HTR3B, GAD1

Molecular functions related to Heroin Dependence according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1benzodiazepine receptor activityGO:00850310.2GABRG2, GABRA6
2monoamine transmembrane transporter activityGO:00850410.2SLC6A3, SLC6A4, SLC6A2
3dopamine bindingGO:03524010.2SLC6A3, DRD4, DRD2
4GABA-A receptor activityGO:00489010.2GABRA6, GABRA1, GABRG2
5dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.1DRD2, DRD4
6extracellular ligand-gated ion channel activityGO:00523010.1GABRG2, GABRA1, GABRA6
7drug bindingGO:00814410.0SLC6A3, GABRA1, DRD4, DRD2, HTR1B
8chloride channel activityGO:0052549.8GABRG2, GABRA1, GABRA6

Products for genes affiliated with Heroin Dependence

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  • Antibodies

Sources for Heroin Dependence

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet