MCID: HRN003
MIFTS: 37

Heroin Dependence malady

Summaries for Heroin Dependence

About this section


Disease Ontology:9 An opiate dependence that involves the continued use of heroin despite problems related to use of the substance.

MalaCards based summary: Heroin Dependence is related to personality disorder and schizophrenia. An important gene associated with Heroin Dependence is ANKK1 (ankyrin repeat and kinase domain containing 1), and among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Hypothetical Network for Drug Addiction. The drugs buprenorphine and buprenorphine hydrochloride and the compounds (-)-sulpiride and (+)-sulpiride have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related mouse phenotype behavior/neurological.

Aliases & Classifications for Heroin Dependence

About this section

Heroin Dependence, Aliases & Descriptions:

Name: Heroin Dependence 9 11 60


External Ids:

Disease Ontology9 DOID:9976
MeSH33 D006556
NCIt38 C34694

Related Diseases for Heroin Dependence

About this section

Diseases related to Heroin Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder30.7HTR1B, DRD4, DRD2
2schizophrenia30.3DRD2, DRD4
3antisocial personality disorder30.3ANKK1, HTR1B, DRD2, GABRA6
4cocaine dependence30.0DRD2, PDYN
5hepatitis10.4
6borderline personality disorder10.4
7alexithymia10.4ANKK1
8oppositional defiant disorder10.3DRD4
9neuroleptic malignant syndrome10.3DRD2
10hepatitis c virus10.2
11hepatitis c10.2
12post-traumatic stress disorder10.2
13blindness10.2
14substance abuse10.2DRD2, DRD4
15delusional disorder10.1DRD4, DRD2
16pathological gambling10.1DRD4, DRD2
17conduct disorder10.1DRD4, DRD2
18hepatitis b10.1
19morphine dependence10.1
20neuronitis10.1
21acquired immunodeficiency syndrome10.1
22glucagonoma10.1
23syncope10.1
24hyperprolactinemia10.0DRD2, DRD4
25opioid dependence10.0DRD2, PDYN
26parkinson disease, late-onset10.0DRD2, PDYN
27nicotine dependence, protection against10.0ANKK1, DRD2, DRD4
28drug dependence10.0DRD2, PDYN
29drug addiction9.9DRD2, PDYN
30attention deficit-hyperactivity disorder9.9DRD2, HTR1B, DRD4
31migraine9.9HTR1B, DRD2, DRD4
32gilles de la tourette syndrome9.9DRD4, DRD2
33substance dependence9.8DRD4, DRD2, PDYN
34psychotic disorder9.8DRD2, DRD4, PDYN
35bipolar disorder9.8DRD2, PDYN, DRD4
36alzheimer disease9.6PDYN, DRD4, DRD2
37obsessive-compulsive disorder9.5DRD4, PDYN, HTR1B, DRD2
38mood disorder9.5DRD2, HTR1B, PDYN, DRD4
39alcohol dependence9.5HTR1B, DRD4, PDYN, DRD2

Graphical network of the top 20 diseases related to Heroin Dependence:



Diseases related to heroin dependence

Symptoms for Heroin Dependence

About this section

Drugs & Therapeutics for Heroin Dependence

About this section

Drug clinical trials:

Search ClinicalTrials for Heroin Dependence

Search NIH Clinical Center for Heroin Dependence

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Heroin Dependence

About this section

Anatomical Context for Heroin Dependence

About this section

MalaCards organs/tissues related to Heroin Dependence:

31
Brain, Testes, Pituitary

Animal Models for Heroin Dependence or affiliated genes

About this section

MGI Mouse Phenotypes related to Heroin Dependence:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.5GABRA6, DRD2, DRD4, PDYN, HTR1B

Publications for Heroin Dependence

About this section

Articles related to Heroin Dependence:

(show top 50)    (show all 205)
idTitleAuthorsYear
1
Long-term mortality, remission, criminality and psychiatric comorbidity of heroin dependence: 11-year findings from the Australian Treatment Outcome Study. (25619110)
2015
2
Chronic heroin dependence leading to adrenal insufficiency. (25221675)
2014
3
Comparative study of the perceived quality of life of patients in treatment for cocaine and heroin dependence in Spain: differences by gender and time in treatment. (24712297)
2014
4
Gender Differences Among Prisoners With Pre-Incarceration Heroin Dependence Participating in a Randomized Clinical Trial of Buprenorphine Treatment. (23997546)
2013
5
Shattered childhoods and the genetics of heroin dependence. (23496065)
2013
6
Case-control study of error-related negativity among males with heroin dependence undergoing rehabilitation. (24991149)
2013
7
The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and borderline personality disorder in female heroin-dependent Chinese subjects. (24355137)
2013
8
Scopolamine detoxification technique for heroin dependence: a randomized trial. (24092568)
2013
9
The ADH1B and DRD2 gene polymorphism may modify the protective effect of the ALDH2 gene against heroin dependence. (23266708)
2013
10
The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects. (22138326)
2012
11
Gender differences in physical and mental health outcomes among an aging cohort of individuals with a history of heroin dependence. (22154506)
2012
12
Heroin dependence duration influences the metabolic parameters: mechanisms and consequences of impaired insulin sensitivity in hepatitis C virus seronegative heroin dependents. (23013781)
2012
13
Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction. (22015315)
2012
14
Cost-effectiveness of buprenorphine and naltrexone treatments for heroin dependence in Malaysia. (23226534)
2012
15
Association between heroin dependence and prodynorphin gene polymorphisms. (21382455)
2011
16
Heroin dependence and bloodborne virus transmission behaviors for HIV infection among newly incarcerated injection drug users in Taiwan. (20964533)
2011
17
Polymorphism G861C of 5-HT receptor subtype 1B is associated with heroin dependence in Han Chinese. (21839728)
2011
18
Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history]. (20517217)
2010
19
Long-acting injectable versus oral naltrexone maintenance therapy with psychosocial intervention for heroin dependence: a quasi-experiment. (20673549)
2010
20
Potential association of DRD2 and DAT1 genetic variation with heroin dependence. (19664686)
2009
21
Open-label dose-finding trial of buprenorphine implants (Probuphine) for treatment of heroin dependence. (19403243)
2009
22
A survey of acute and chronic heroin dependence in ten inbred mouse strains: evidence of genetic correlation with morphine dependence. (18472145)
2008
23
Single versus repeated sessions of ketamine-assisted psychotherapy for people with heroin dependence. (17523581)
2007
24
Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen. (17344330)
2007
25
The effect of baseline cocaine use on treatment outcomes for heroin dependence over 24 months: findings from the Australian Treatment Outcome Study. (17889301)
2007
26
A randomized trial of effectiveness and cost-effectiveness of observed versus unobserved administration of buprenorphine-naloxone for heroin dependence. (17784896)
2007
27
Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis. (17416470)
2007
28
Mental health outcomes following naltrexone implant treatment for heroin-dependence. (17229510)
2007
29
Early impact of methadone induction for heroin dependence: differential effects of two dose sequences in a randomized controlled study. (16503705)
2006
30
Follow-up difficulty: correlates and relationship with outcome in heroin dependence treatment in the NEPOD study. (16243439)
2006
31
How quick to heroin dependence? (16939944)
2006
32
A randomised trial of the cost effectiveness of buprenorphine as an alternative to methadone maintenance treatment for heroin dependence in a primary care setting. (15693730)
2005
33
Depression among entrants to treatment for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence, correlates and treatment seeking. (15893162)
2005
34
Naltrexone maintenance for heroin dependence: uptake, attrition and retention. (15370010)
2004
35
Adherence to heroin dependence therapies and human immunodeficiency virus/acquired immunodeficiency syndrome infection rates among drug abusers. (14648465)
2003
36
Neuroendocrine correlates of antisocial personality disorder in abstinent heroin-dependent subjects. (12745412)
2003
37
New aspects in the treatment of heroin dependence with special reference to neurobiological aspects. (12052577)
2002
38
Buprenorphine maintenance treatment of heroin dependence: the first experience from Iran. (12039619)
2002
39
Treatment of heroin dependence with buprenorphine in primary care. (12014814)
2002
40
Treatment of heroin dependence. (11177323)
2001
41
Gamma-hydroxybutyric acid in the treatment of alcohol and heroin dependence. (10869867)
2000
42
Neuroendocrine correlates of depression in abstinent heroin-dependent subjects. (11084218)
2000
43
The medical management of adolescent heroin dependence. (11123006)
2000
44
Predictors of inpatient treatment completion of subjects with heroin dependence. (21584093)
1997
45
Buprenorphine versus heroin dependence: comparison of toxicologic and psychopathologic characteristics. (8480833)
1993
46
Cocaine and heroin dependence compared in poly-drug abusers. (3354742)
1988
47
Letter: Nature of heroin dependence. (4407952)
1974
48
Heroin dependence and delinquency in women--a study of heroin addicts in Holloway prison. (5270380)
1970
49
Naloxone in heroin dependence. (5676799)
1968
50
Morbidity and mortality from heroin dependence. 3. Relation of hepatitis to self-injection techniques. (5641436)
1968

Variations for Heroin Dependence

About this section

Expression for genes affiliated with Heroin Dependence

About this section
Search GEO for disease gene expression data for Heroin Dependence.

Pathways for genes affiliated with Heroin Dependence

About this section

Pathways related to Heroin Dependence according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Nicotine Activity on Dopaminergic Neurons36
9.4DRD2, DRD4
29.4DRD2, DRD4
3
Show member pathways
9.1DRD2, PDYN
4
Show member pathways
8.8HTR1B, DRD4, DRD2
5
Show member pathways
8.4HTR1B, DRD4, DRD2, GABRA6
6
Show member pathways
8.0HTR1B, PDYN, DRD4, DRD2
7
Show member pathways
7.5GABRA6, DRD2, DRD4, PDYN, HTR1B

Compounds for genes affiliated with Heroin Dependence

About this section

Compounds related to Heroin Dependence according to GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1(-)-sulpiride289.8DRD4, DRD2
2(+)-sulpiride289.8DRD4, DRD2
3melperone439.8DRD4, DRD2
4eticlopride43 2810.8DRD2, DRD4
5sch 23390439.7DRD2, DRD4
6(+)-butaclamol43 2810.7DRD2, DRD4
7remoxipride43 1210.7DRD4, DRD2
8loxapine28 43 1211.7DRD4, DRD2
9piribedil28 4310.7DRD2, DRD4
10benzamide2 4310.7DRD2, DRD4
11rotigotine28 43 1211.6DRD4, DRD2
12raclopride43 2810.6DRD4, DRD2
13fluphenazine28 43 49 1212.6DRD2, DRD4
14antipsychotics499.5DRD2, ANKK1
15spiperone43 2810.5DRD4, DRD2
16nemonapride43 49 2811.5DRD2, DRD4, ANKK1
17ritanserin43 2810.4HTR1B, DRD2
18piperazine43 1210.4DRD4, DRD2
19methylphenidate43 49 1211.3DRD2, DRD4
20roxindole28 4310.3DRD2, DRD4, HTR1B
21terguride43 2810.2DRD2, DRD4, HTR1B
22ropinirole43 1210.2HTR1B, DRD4, DRD2
23maoa439.2HTR1B, DRD4, DRD2
24lisuride43 28 1211.2DRD2, DRD4, HTR1B
25pergolide43 28 1211.2HTR1B, DRD4, DRD2
26pramipexole43 28 49 1212.2DRD2, DRD4, HTR1B
27asenapine28 1210.2HTR1B, DRD4, DRD2
28cabergoline43 28 1211.2DRD2, DRD4, HTR1B
29aripiprazole28 43 49 24 1213.2DRD2, DRD4, HTR1B
30ziprasidone28 49 43 1212.2HTR1B, DRD4, DRD2
31apomorphine28 43 1211.2HTR1B, DRD4, DRD2
32quetiapine43 49 28 24 1213.2DRD2, DRD4, HTR1B
33bromocriptine43 28 1211.2DRD2, DRD4, HTR1B
34methadone49 43 1211.1DRD2, PDYN, ANKK1
355-hydroxytryptamine439.0HTR1B, DRD4, DRD2
36sulpiride43 28 1211.0PDYN, DRD4, DRD2
37sertindole28 43 1211.0DRD2, HTR1B
38quinpirole43 2810.0DRD2, DRD4, PDYN
39heroin43 49 1211.0PDYN, DRD4, DRD2
40methamphetamine43 49 1211.0PDYN, DRD4, DRD2
416-hydroxydopamine439.0DRD2, DRD4, PDYN
42amphetamine43 49 1211.0PDYN, DRD4, DRD2
43risperidone43 49 28 59 24 1213.9DRD2, DRD4, HTR1B, ANKK1
44olanzapine43 49 28 24 1212.8ANKK1, HTR1B, DRD4, DRD2
45clozapine43 28 49 1211.8ANKK1, HTR1B, DRD4, DRD2
46nicotine43 28 49 1211.6DRD2, DRD4, PDYN, ANKK1
47gaba438.5GABRA6, DRD2, DRD4, PDYN
48levodopa43 129.4DRD2, DRD4, PDYN, HTR1B
49cocaine43 129.4DRD2, DRD4, PDYN, HTR1B
50dopamine43 28 24 1211.3HTR1B, PDYN, DRD4, DRD2

GO Terms for genes affiliated with Heroin Dependence

About this section

Cellular components related to Heroin Dependence according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:00431979.4DRD2, DRD4
2integral component of plasma membraneGO:00058878.3GABRA6, HTR1B, DRD4, DRD2
3plasma membraneGO:00058867.2GABRA6, HTR1B, PDYN, DRD4, DRD2

Biological processes related to Heroin Dependence according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:00347769.7DRD4, DRD2
2positive regulation of dopamine uptake involved in synaptic transmissionGO:00515869.7DRD4, DRD2
3negative regulation of voltage-gated calcium channel activityGO:019013869.7DRD4, DRD2
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00071959.7DRD4, DRD2
5behavioral response to ethanolGO:00481499.7DRD2, DRD4
6dopamine metabolic processGO:00424179.7DRD4, DRD2
7negative regulation of protein secretionGO:00507099.7DRD2, DRD4
8synaptic transmission, dopaminergicGO:00019639.6DRD2, DRD4
9negative regulation of synaptic transmission, glutamatergicGO:00519679.6DRD2, HTR1B
10behavioral response to cocaineGO:00481489.5DRD2, DRD4
11negative regulation of cAMP biosynthetic processGO:00308189.5HTR1B, DRD4
12arachidonic acid secretionGO:00504829.5DRD4, DRD2
13G-protein coupled receptor internalizationGO:00020319.5DRD2, HTR1B
14cellular calcium ion homeostasisGO:00068749.4DRD4, DRD2
15negative regulation of adenylate cyclase activityGO:00071949.3DRD2, DRD4
16response to cocaineGO:00422209.3DRD2, HTR1B
17response to amphetamineGO:00019759.1DRD4, DRD2

Molecular functions related to Heroin Dependence according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1potassium channel regulator activityGO:00154599.4DRD2, DRD4
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00015919.3DRD2, DRD4
3dopamine bindingGO:00352409.1DRD2, DRD4
4drug bindingGO:00081448.8DRD2, DRD4, HTR1B

Products for genes affiliated with Heroin Dependence

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Heroin Dependence

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet