MCID: HRP006
MIFTS: 70

Herpes Simplex

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Herpes Simplex

MalaCards integrated aliases for Herpes Simplex:

Name: Herpes Simplex 12 51 40 41 14
Herpesvirus Hominis Disease 12
Herpes Simplex Infections 69
Herpes Simplex Disease 72

Classifications:



External Ids:

Disease Ontology 12 DOID:8566
ICD10 32 B00 B00.9
ICD9CM 34 054
MeSH 41 D006561
UMLS 69 C0019348

Summaries for Herpes Simplex

MedlinePlus : 40 Herpes is an infection that is caused by a herpes simplex virus (HSV). Oral herpes causes cold sores around the mouth or face. Genital herpes affects the genitals, buttocks or anal area. Genital herpes is a sexually transmitted disease (STD). It affects the genitals, buttocks or anal area. Other herpes infections can affect the eyes, skin, or other parts of the body. The virus can be dangerous in newborn babies or in people with weak immune systems. There are two types of HSV: HSV type 1 most commonly causes cold sores. It can also cause genital herpes. HSV type 2 is the usual cause of genital herpes, but it also can infect the mouth. HSV spreads through direct contact. Some people have no symptoms. Others get sores near the area where the virus has entered the body. They turn into blisters, become itchy and painful, and then heal. Most people have outbreaks several times a year. Over time, you get them less often. Medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards based summary : Herpes Simplex, also known as herpesvirus hominis disease, is related to herpes simplex encephalitis and encephalitis, and has symptoms including snoring, pruritus and pelvic pain. An important gene associated with Herpes Simplex is NECTIN1 (Nectin Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ganciclovir and Docosanol have been mentioned in the context of this disorder. Affiliated tissues include mouth, face and genitalia, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A viral infectious disease that results_in_formation_of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person.

Wikipedia : 72 Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and... more...

Related Diseases for Herpes Simplex

Diseases in the Herpes Simplex family:

Congenital Herpes Simplex

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 492)
# Related Disease Score Top Affiliating Genes
1 herpes simplex encephalitis 34.4 IRF3 TICAM1 TLR3 TRAF3 UNC93B1
2 encephalitis 31.9 IRF3 TICAM1 TLR3 TRAF3 UNC93B1
3 rabies 29.9 IRF3 PML TLR3
4 influenza 29.3 EIF2AK2 PML TLR3 TLR9
5 herpes simplex encephalitis 1 12.6
6 herpes simplex virus keratitis 12.5
7 herpes simplex encephalitis 2 12.4
8 herpes simplex encephalitis 4 12.4
9 herpes simplex encephalitis 3 12.4
10 congenital herpes simplex virus infection 12.4
11 herpes simplex encephalitis 7 12.4
12 eczema herpeticum 12.3
13 congenital herpes simplex 12.3
14 genital herpes 12.0
15 neonatal herpes 11.7
16 herpetic whitlow 11.5
17 mollaret meningitis 11.5
18 erythema multiforme 11.4
19 acute retinal necrosis syndrome 11.4
20 proctitis 11.4
21 cytomegalovirus infection 11.4
22 viral pneumonia 11.4
23 aphthous stomatitis 11.4
24 cytomegalic inclusion disease 11.4
25 hyper-ige recurrent infection syndrome, autosomal recessive 11.0
26 caspase 8 deficiency 11.0
27 salivary gland disease 11.0
28 pseudomembranous conjunctivitis 11.0
29 herpetic gastritis 11.0
30 congenital intrauterine infection-like syndrome 11.0
31 pudendal neuralgia 11.0
32 neurological consequences of cytomegalovirus infection 11.0
33 keratitis, hereditary 10.8
34 stromal keratitis 10.5
35 retinitis 10.4
36 neuronitis 10.4
37 cleft lip/palate-ectodermal dysplasia syndrome 10.4 NECTIN1 NECTIN2 TNFRSF14
38 meningitis 10.4
39 hepatitis 10.4
40 pneumonia 10.3
41 glioma 10.3
42 leukemia 10.3
43 cervicitis 10.3
44 endotheliitis 10.3
45 bell's palsy 10.2
46 mucositis 10.2
47 cerebritis 10.2
48 idiopathic recurrent and disabling cutaneous herpes 10.2
49 meningoencephalitis 10.2
50 esophagitis 10.2

Graphical network of the top 20 diseases related to Herpes Simplex:



Diseases related to Herpes Simplex

Symptoms & Phenotypes for Herpes Simplex

UMLS symptoms related to Herpes Simplex:


snoring, pruritus, pelvic pain, halitosis, fever

MGI Mouse Phenotypes related to Herpes Simplex:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 TRAF3 UNC93B1 PML POU2F1 TAP1 TAP2
2 immune system MP:0005387 9.77 TRAF3 IRF3 UNC93B1 PML TAP1 TAP2
3 mortality/aging MP:0010768 9.47 HCFC1 TRAF3 NECTIN1 UNC93B1 PML POU2F1

Drugs & Therapeutics for Herpes Simplex

Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 232)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 1 82410-32-0 3454
2
Docosanol Approved, Investigational Phase 4 661-19-8, 30303-65-2 12620
3
Famciclovir Approved, Investigational Phase 4,Phase 3,Phase 2 104227-87-4 3324
4
Penciclovir Approved Phase 4,Phase 3 39809-25-1 4725
5
Metronidazole Approved Phase 4 443-48-1 4173
6 Acyclovir Phase 4,Phase 3,Phase 2,Phase 1
7 valacyclovir Phase 4,Phase 3,Phase 2,Phase 1
8 Ganciclovir triphosphate Phase 4,Phase 2,Phase 1
9 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
11
Tenofovir Phase 4,Phase 3,Phase 1 147127-20-6 464205
12 2-Aminopurine Phase 4,Phase 3,Phase 2
13 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
14 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
15 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
16 Anti-HIV Agents Phase 4,Phase 3,Phase 1
17 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
18 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Antiprotozoal Agents Phase 4
20 Antiparasitic Agents Phase 4
21
Ethanol Approved Phase 3,Phase 2 64-17-5 702
22
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
23
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
24
Edetic Acid Approved, Vet_approved Phase 3,Phase 1 60-00-4, 62-33-9 6049
25 Cetylpyridinium Approved Phase 3 7773-52-6
26
Zinc Approved, Investigational Phase 3 7440-66-6 32051 23994
27
Melphalan Approved Phase 3 148-82-3 460612 4053
28
Vidarabine Approved, Investigational Phase 3 24356-66-9 21704 32326
29
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 657311 5754
30
Foscarnet Approved Phase 3,Phase 2,Phase 1 4428-95-9, 63585-09-1 3415
31
Halofantrine Approved Phase 3 69756-53-2 37393
32
Zanamivir Approved, Investigational Phase 3 139110-80-8 60855
33
Aluminum sulfate Approved Phase 3,Phase 1,Phase 2 10043-01-3
34
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
35
Methylene blue Approved, Investigational Phase 3 61-73-4
36
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1 77-92-9 311
37
Phosphonoacetic Acid Experimental Phase 3,Phase 2,Phase 1 4408-78-0 546
38
Butyric Acid Experimental, Investigational Phase 3 107-92-6 264
39 Prednisolone acetate Phase 3
40 glucocorticoids Phase 3,Phase 2,Phase 1
41 5- ((2- (6- Amino- 9H- purin- 9- yl) ethyl) amino) - 1- pentanol Phase 3,Phase 2
42 Methylprednisolone acetate Phase 3
43 Methylprednisolone Hemisuccinate Phase 3
44 Gastrointestinal Agents Phase 3,Phase 1
45 Neuroprotective Agents Phase 3
46 Hormone Antagonists Phase 3,Phase 2,Phase 1
47 Hormones Phase 3,Phase 2,Phase 1
48 Pentetic Acid Phase 3,Phase 1
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
50 Peripheral Nervous System Agents Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 276)

# Name Status NCT ID Phase Drugs
1 Comparison of Topical Antiviral Agents for Labial Cold Sores (Herpes Labialis) Unknown status NCT00467662 Phase 4 Acyclovir 5%;Docosanol 10%
2 Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding Completed NCT01448616 Phase 4 TDF;Placebo Vaginal Gel;Vaginal TFV Gel;Placebo Tablets
3 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4 Metronidazole
4 Palatability Testing of a New Paediatric Formulation of Valacyclovir Completed NCT01682109 Phase 4 Valacyclovir
5 A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. Completed NCT00158860 Phase 4 valaciclovir (VALTREX®)
6 Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV Completed NCT00527618 Phase 4 valacyclovir;acyclovir
7 Valacyclovir Augmentation for Cognitive and Functional Remediation in Schizophrenia Completed NCT01794897 Phase 4 Experimental: Valacyclovir treatment;Placebo comparator
8 A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons Completed NCT00161434 Phase 4 valacyclovir;placebo
9 Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT01346475 Phase 4 valacyclovir;Valacyclovir
10 A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation Completed NCT00723229 Phase 4 acyclovir
11 Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT00362297 Phase 4 acyclovir;valacyclovir
12 VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies. Completed NCT00116844 Phase 4 Valaciclovir;Placebo
13 Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons Completed NCT01026454 Phase 4 acyclovir;valacyclovir
14 A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand Completed NCT00362596 Phase 4 acyclovir
15 A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers Completed NCT00820534 Phase 4 Penciclovir;Placebo
16 Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients Completed NCT00477334 Phase 4 Famciclovir;Placebo
17 VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2 Completed NCT00306293 Phase 4 valacyclovir
18 A Study to Evaluate the Safety and Efficacy of Single Day or Single Dose Famciclovir for the Treatment of Recurrent Herpes Labialis Completed NCT00248144 Phase 4 Famciclovir
19 RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir Completed NCT00219310 Phase 4 Famciclovir
20 A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding Completed NCT00129818 Phase 4 Famciclovir
21 PTH - Preemptive Treatment for Herpesviridae Recruiting NCT02152358 Phase 4 Aciclovir;Ganciclovir;Placebo
22 Effect of HSV-2 Suppressive Therapy on Sexual Behavior Active, not recruiting NCT00495716 Phase 4 acyclovir;acyclovir
23 The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis Terminated NCT02045082 Phase 4
24 A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons Terminated NCT00079911 Phase 4 valacyclovir hydrochloride
25 A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients Unknown status NCT00005663 Phase 3 Valacyclovir hydrochloride
26 Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Involving the Central Nervous System Unknown status NCT00006132 Phase 3 acyclovir
27 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
28 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
29 NB-001 Treatment of Recurrent Herpes Labialis Unknown status NCT01695187 Phase 3 NB-001 (0.3%);Placebo
30 Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease Completed NCT00699764 Phase 3
31 Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects Completed NCT00698568 Phase 3
32 Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old Completed NCT00224484 Phase 3
33 Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth Completed NCT00031447 Phase 3 Acyclovir;Placebo
34 Open-label Study of ASP2151 in Herpes Simplex Patients Completed NCT02209324 Phase 3 ASP2151
35 Study to Compare Safety and Immunogenicity of Commercial Scale Consistency Lots of Herpes Simplex Vaccine Completed NCT00224471 Phase 3
36 Phase III Study of ASP2151 in Herpes Simplex Patients Completed NCT01959295 Phase 3 ASP2151;ASP2151 placebo
37 Valaciclovir Hydrochloride Phase III for Hematopoietic Stem Cell Transplantation Patients Completed NCT01602562 Phase 3 VACV tablets (Adults or pediatrics) or granules (pediatrics)
38 Acyclovir in Preventing Herpes Simplex Virus Infection in Patients With Neutropenia Completed NCT00855309 Phase 3 acyclovir sodium
39 Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates Completed NCT00031460 Phase 3 Acyclovir;Placebo
40 Valaciclovir to Prevent Transmission of Herpes Simplex Virus Completed NCT00001649 Phase 3 Valaciclovir
41 Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection Completed NCT00098059 Phase 3 Famciclovir
42 Zinc for the Treatment of Herpes Simplex Labialis (HSL) Completed NCT00809809 Phase 3 Zicam (Ionic zinc);placebo
43 Long Term Treatment of Herpes Simplex Encephalitis (HSE) With Valacyclovir Completed NCT00031486 Phase 3 Valacyclovir;Placebo
44 Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Limited to Skin, Eyes, and Mouth Completed NCT00006135 Phase 3 acyclovir
45 Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth Completed NCT00004757 Phase 3 acyclovir
46 HerpeVac Trial for Young Women Completed NCT00057330 Phase 3
47 Safety and Effectiveness of Tenofovir Gel in the Prevention of Human Immunodeficiency Virus (HIV-1) Infection in Women and the Effects of Tenofovir Gel on the Incidence of Herpes Simplex Virus (HSV-2) Infection Completed NCT01386294 Phase 3 Tenofovir gel;Universal placebo gel
48 Comparison of Foscarnet Versus Vidarabine in the Treatment of Herpes Infection in Patients With AIDS Who Have Not Had Success With Acyclovir Completed NCT00000985 Phase 3 Vidarabine;Acyclovir;Foscarnet sodium
49 Safety Study of ME-609 for Treatment of Herpes Simplex Labialis in Adolescents Completed NCT00375570 Phase 3 ME-609
50 Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis in Immunocompromised Patients Completed NCT00735761 Phase 3 ME-609;Acyclovir in ME-609 vehicle (5% acyclovir)

Search NIH Clinical Center for Herpes Simplex

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: herpes simplex

Genetic Tests for Herpes Simplex

Anatomical Context for Herpes Simplex

The Foundational Model of Anatomy Ontology organs/tissues related to Herpes Simplex:

18
Mouth, Face, Genitalia, H

MalaCards organs/tissues related to Herpes Simplex:

38
Skin, Eye, T Cells, Brain, Liver, Testes, Colon

Publications for Herpes Simplex

Articles related to Herpes Simplex:

(show top 50) (show all 3127)
# Title Authors Year
1
Semantic language deficit developing following herpes simplex encephalitis: reorganization "cannibalising" language centers? ( 29350572 )
2018
2
A Case of Bell's Palsy Complicated by Subsequent Herpes Simplex Virus Encephalitis. ( 29144221 )
2018
3
A case of Kaposi varicelliform eruption progressing to herpes simplex virus hepatitis in an immunocompetent patient. ( 29446473 )
2018
4
Premature Termination of Treatment in Neonatal Herpes Simplex Virus Encephalitis. ( 29174006 )
2018
5
Corneal perforation after noncontact tonometry in patients with active recurrent herpes simplex keratitis: case report. ( 29417444 )
2018
6
Analysis of Select Herpes Simplex Virus 1 (HSV-1) Proteins for Restriction of Human Immunodeficiency Virus Type 1 (HIV-1): HSV-1 gM Protein Potently Restricts HIV-1 by Preventing Intracellular Transport and Processing of Env gp160. ( 29093081 )
2018
7
Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication. ( 29447697 )
2018
8
Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains. ( 29427675 )
2018
9
CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection. ( 29437926 )
2018
10
Herpes Simplex Virus 1 Dramatically Alters Loading and Positioning of RNA Polymerase II on Host Genes Early in Infection. ( 29437966 )
2018
11
Proteomic Analysis of Secretomes of Oncolytic Herpes Simplex Virus-Infected Squamous Cell Carcinoma Cells. ( 29360750 )
2018
12
Pneumomediastinum and Pneumothorax Associated with Herpes Simplex Virus (HSV) Pneumonia. ( 29379004 )
2018
13
Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis. ( 29370719 )
2018
14
Disseminated herpes simplex virus and varicella zoster virus co-infection in an immunocompetent patient. ( 29451195 )
2018
15
An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye. ( 29444978 )
2018
16
Herpes simplex encephalitis relapse associated with positive N-methyl-D-aspartate receptor antibodies. ( 29450730 )
2018
17
Extended Synaptotagmin 1 Interacts with Herpes Simplex Virus 1 Glycoprotein M and Negatively Modulates Virus-Induced Membrane Fusion. ( 29046455 )
2018
18
Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. ( 29256984 )
2018
19
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. ( 29345511 )
2018
20
QuickStats: Age-Adjusted* Trends in the Prevalence of Herpes Simplex Virus Type 1 (HSV-1) and Herpes Simplex Virus Type 2 (HSV-2) Among Adolescents and Adults Aged 14-49 Years - United States, 1999-2000 Through 2015-2016. ( 29447144 )
2018
21
Update on Neonatal Herpes Simplex Epidemiology in the Netherlands: A Health Problem of Increasing Concern? ( 29356762 )
2018
22
Reactivation of herpes simplex viral keratitis following the botulinum toxin injection. ( 29380788 )
2018
23
Functional failure of TLR3 and its signaling components contribute to herpes simplex encephalitis. ( 29305044 )
2018
24
ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum. ( 29371118 )
2018
25
A case of herpes simplex virus pneumonia detected by sputum cytodiagnosis. ( 29375858 )
2018
26
Prevalence of Herpes Simplex Virus Type 1 and Type 2 in Persons Aged 14-49: United States, 2015-2016. ( 29442994 )
2018
27
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis. ( 29113740 )
2018
28
Rapid acquisition of acyclovir resistance in an immunodeficient patient with herpes simplex encephalitis. ( 29249385 )
2018
29
Herpes simplex virus type 2 IgG antibodies in sera of umbilical cord as a proxy for placental infection in asymptomatic pregnant women. ( 29427299 )
2018
30
Screening Cerebrospinal Fluid Prior to Herpes Simplex Virus PCR Testing Might Miss Cases of Herpes Simplex Encephalitis. ( 28947509 )
2017
31
Concomitant neurosyphilis and herpes simplex encephalitis in an immunocompetent patient: a case report. ( 28914386 )
2017
32
Psychosis in a 15-Year-Old Female with Herpes Simplex Encephalitis in a Background of Mannose-Binding Lecithin Deficiency. ( 28261514 )
2017
33
Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1. ( 28592536 )
2017
34
An Interleukin 12 Adjuvanted Herpes Simplex Virus 2 DNA Vaccine Is More Protective Than a Glycoprotein D Subunit Vaccine in a High-Dose Murine Challenge Model. ( 28085634 )
2017
35
Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K. ( 28724772 )
2017
36
Congenital Herpes Simplex Virus Type 1 Infection Mimicking Congenital Erosive and Vesicular Dermatosis: Possible Pathogenic Insights. ( 28543846 )
2017
37
Ulcerating Herpes Simplex Infection. ( 28927502 )
2017
38
Genome-wide engineering of an infectious clone of herpes simplex virus type 1 using synthetic genomics assembly methods. ( 28928148 )
2017
39
Herpes Simplex Encephalitis Complicated by Cerebral Hemorrhage during Acyclovir Therapy. ( 28090058 )
2017
40
Herpes Simplex Virus Keratitis and Resistance to Acyclovir. ( 28060081 )
2017
41
Disseminated Neonatal Herpes Simplex Virus Infection with Escherichia Coli Coinfection. ( 28678413 )
2017
42
Herpes simplex encephalitis with thalamic, brainstem and cerebellar involvement. ( 28627955 )
2017
43
Leflunomide in the Treatment of a Pseudotumoral Genital Herpes Simplex Virus Infection in an HIV Patient. ( 28373917 )
2017
44
Anti-N-methyl-D-aspartate receptor encephalitis during relapse of herpes simplex encephalitis in a young boy: A brief review of literature. ( 28290410 )
2017
45
Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis. ( 28891812 )
2017
46
Retrospective Identification of Herpes Simplex 2 Virus-Associated Acute Liver Failure in an Immunocompetent Patient Detected Using Whole Transcriptome Shotgun Sequencing. ( 29441209 )
2017
47
TLR3 Mutations in Adult Patients With Herpes Simplex Virus and Varicella-Zoster Virus Encephalitis. ( 28368532 )
2017
48
Review of Viral Encephalitis Cases Seen at a Tertiary Care Center in Turkey: Focus on Herpes Simplex Type 1. ( 29033632 )
2017
49
Evaluation of Herpes Simplex Virus Type 2 Serological Tests for Use With Dried Blood Spots in Kenya. ( 28081046 )
2017
50
Pure word deafness due to herpes simplex encephalitis. ( 28017194 )
2017

Variations for Herpes Simplex

Expression for Herpes Simplex

LifeMap Discovery
Genes differentially expressed in tissues of Herpes Simplex patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 FCN1 ficolin (collagen/fibrinogen domain containing) 1 Skin + 3.89 0.000
2 IRF1 interferon regulatory factor 1 Skin + 3.58 0.000
3 STAT1 signal transducer and activator of transcription 1, 91kDa Skin + 3.53 0.000
4 RARRES3 retinoic acid receptor responder (tazarotene induced) 3 Skin + 3.49 0.000
5 SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 Skin + 3.41 0.000
6 CCL19 chemokine (C-C motif) ligand 19 Skin + 3.32 0.003
7 XAF1 XIAP associated factor 1 Skin + 3.04 0.000
Search GEO for disease gene expression data for Herpes Simplex.

Pathways for Herpes Simplex

Pathways related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 C3 EIF2AK2 IFI16 IRF3 NECTIN2 PML
2
Show member pathways
13.22 EIF2AK2 IRF3 PML POU2F1 TNFRSF14 TNFSF14
3
Show member pathways
12.84 CREB3 EIF2AK2 IRF3 TBP TICAM1 TLR3
4
Show member pathways
12.81 IFI16 IRF3 TICAM1 TLR3 TLR9 TRAF3
5
Show member pathways
12.49 CREB3 EIF2AK2 PML TBP TRAF3
6
Show member pathways
12.44 CREB3 IRF3 TLR3 TLR9 TNFRSF14 TNFSF14
7
Show member pathways
12.4 C3 IRF3 TICAM1 TLR3 TLR9 TRAF3
8
Show member pathways
12.32 C3 CREB3 EIF2AK2 IRF3 TICAM1 TLR3
9
Show member pathways
12.29 IFI16 IRF3 TICAM1 TLR3
10
Show member pathways
12.22 C3 EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2
11 12.14 EIF2AK2 IRF3 TBP TRAF3
12
Show member pathways
12.13 IRF3 TICAM1 TLR3 TLR9 TRAF3
13 12.1 C3 CREB3 EIF2AK2 IRF3 TBP TRAF3
14 12.07 IFI16 IRF3 TAP1 TAP2 TICAM1 TLR3
15 11.92 EIF2AK2 IRF3 TICAM1 TLR3 TRAF3
16 11.74 TICAM1 TNFSF14 TRAF3
17 11.66 C3 TLR3 TLR9
18 11.6 C3 IRF3 TICAM1
19 11.46 NECTIN2 TNFRSF14 TNFSF14

GO Terms for Herpes Simplex

Cellular components related to Herpes Simplex according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.83 PML TLR3 TLR9 TRAF3 UNC93B1
2 endoplasmic reticulum GO:0005783 9.76 CREB3 PML POU2F1 TAP1 TAP2 TLR3
3 endoplasmic reticulum membrane GO:0005789 9.5 CREB3 PML TAP1 TAP2 TLR3 TLR9
4 cell-cell contact zone GO:0044291 9.4 NECTIN1 NECTIN2
5 apical junction complex GO:0043296 9.37 NECTIN1 NECTIN2
6 endolysosome membrane GO:0036020 9.32 TLR3 TLR9
7 early phagosome GO:0032009 9.26 TLR9 UNC93B1
8 TAP complex GO:0042825 8.62 TAP1 TAP2

Biological processes related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.95 C3 IFI16 TICAM1 TLR3 TLR9 TNFRSF14
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 IRF3 TICAM1 TLR3 TLR9
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 EIF2AK2 TICAM1 TLR3 TLR9
4 innate immune response GO:0045087 9.85 C3 EIF2AK2 IFI16 IRF3 PML TICAM1
5 viral entry into host cell GO:0046718 9.83 NECTIN1 NECTIN2 TNFRSF14
6 apoptotic signaling pathway GO:0097190 9.82 TICAM1 TLR3 TNFRSF14
7 defense response to virus GO:0051607 9.8 EIF2AK2 IFI16 IRF3 PML TICAM1 TLR3
8 positive regulation of tumor necrosis factor production GO:0032760 9.77 TICAM1 TLR3 TLR9
9 positive regulation of interleukin-6 production GO:0032755 9.77 TICAM1 TLR3 TLR9
10 response to exogenous dsRNA GO:0043330 9.73 IRF3 TICAM1 TLR3
11 positive regulation of type I interferon production GO:0032481 9.73 IFI16 IRF3 TICAM1 TLR3
12 positive regulation of cytokine production GO:0001819 9.72 EIF2AK2 IFI16 TLR3
13 toll-like receptor signaling pathway GO:0002224 9.71 TLR3 TLR9 TRAF3 UNC93B1
14 positive regulation of interferon-beta production GO:0032728 9.7 IRF3 TLR3 TLR9
15 viral process GO:0016032 9.7 CREB3 EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2
16 necroptotic process GO:0070266 9.67 TICAM1 TLR3
17 positive regulation of chemokine production GO:0032722 9.67 EIF2AK2 TLR3 TLR9
18 toll-like receptor 9 signaling pathway GO:0034162 9.66 TLR9 UNC93B1
19 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.65 TLR3 TLR9
20 I-kappaB phosphorylation GO:0007252 9.65 TLR3 TLR9
21 peptide transport GO:0015833 9.65 TAP1 TAP2
22 positive regulation of chemokine biosynthetic process GO:0045080 9.64 TICAM1 TLR3
23 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.63 TAP1 TAP2
24 toll-like receptor 3 signaling pathway GO:0034138 9.63 TICAM1 TLR3 UNC93B1
25 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.62 TICAM1 TLR3
26 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.62 TAP1 TAP2
27 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.62 IRF3 TICAM1 TLR3 TRAF3
28 cellular response to dsRNA GO:0071359 9.61 IRF3 TLR3
29 positive regulation of toll-like receptor signaling pathway GO:0034123 9.58 TLR3 TLR9
30 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.57 TLR3 TLR9
31 cytosol to ER transport GO:0046967 9.54 TAP1 TAP2
32 positive regulation of interferon-beta biosynthetic process GO:0045359 9.54 TICAM1 TLR3 TLR9
33 immune system process GO:0002376 9.4 C3 EIF2AK2 IFI16 IRF3 PML TAP1
34 signal transduction GO:0007165 10.27 C3 NECTIN1 NECTIN2 TICAM1 TLR3 TLR9
35 apoptotic process GO:0006915 10.11 IFI16 IRF3 PML TICAM1 TNFSF14 TRAF3
36 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 CREB3 HCFC1 IFI16 IRF3 PML POU2F1

Molecular functions related to Herpes Simplex according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.91 IRF3 NECTIN1 NECTIN2 PML TAP1 TLR9
2 protein binding GO:0005515 9.91 C3 CREB3 EIF2AK2 HCFC1 IFI16 IRF3
3 virus receptor activity GO:0001618 9.58 NECTIN1 NECTIN2 TNFRSF14
4 MHC protein binding GO:0042287 9.37 TAP1 TAP2
5 peptide-transporting ATPase activity GO:0015440 9.32 TAP1 TAP2
6 TAP1 binding GO:0046978 9.26 TAP1 TAP2
7 peptide transporter activity GO:0015197 9.16 TAP1 TAP2
8 MHC class Ib protein binding GO:0023029 8.62 TAP1 TAP2

Sources for Herpes Simplex

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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