MCID: HRP006
MIFTS: 57

Herpes Simplex malady

Summaries for Herpes Simplex

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Herpes is an infection that is caused by a herpes simplex virus (hsv). oral herpes causes cold sores around the mouth or face. genital herpes affects the genitals, buttocks or anal area. genital herpes is a sexually transmitted disease (std). it affects the genitals, buttocks or anal area. other herpes infections can affect the eyes, skin, or other parts of the body. the virus can be dangerous in newborn babies or in people with weak immune systems. there are two types of hsv: hsv type 1 most commonly causes cold sores. it can also cause genital herpes. hsv type 2 is the usual cause of genital herpes, but it also can infect the mouth. hsv spreads direct contact. some people have no symptoms. others get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. most people have outbreaks several times a year. over time, you get them less often. medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards: Herpes Simplex, also known as herpesvirus hominis disease, is related to hepatitis c and arthritis. An important gene associated with Herpes Simplex is TNFRSF14 (tumor necrosis factor receptor superfamily, member 14), and among its related pathways are Influenza A and Immune System. The drugs benzocaine and methylene blue and the compounds tyrosine and poly(i-c) have been mentioned in the context of this disorder. Affiliated tissues include mouth, face and genitalia.

Disease Ontology:8 A viral infectious disease that results in formation of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia:64 Herpes simplex (Greek: ἕρπης herpēs, \"creeping\" or \"latent\") is a viral disease from the... more...

Aliases & Classifications for Herpes Simplex

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM
See all sources

Aliases & Descriptions:

herpes simplex 8 10 45 34
herpesvirus hominis disease 8
herpes simplex infections 61


External Ids:

Disease Ontology8 DOID:8566
MeSH35 D006561
ICD9CM27 054

Related Diseases for Herpes Simplex

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Herpes Simplex:



Diseases related to herpes simplex

Clinical Features for Herpes Simplex

Drugs & Therapeutics for Herpes Simplex

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Herpes Simplex

Drug clinical trials:

Search ClinicalTrials for Herpes Simplex

Search NIH Clinical Center for Herpes Simplex

Search CenterWatch for Herpes Simplex

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Herpes Simplex

Anatomical Context for Herpes Simplex

Sources:
14FMA
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FMA organs/tissues related to Herpes Simplex:

14
Mouth, Face, Genitalia, H

Animal Models for Herpes Simplex or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Herpes Simplex

Sources:
51PubMed
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Articles related to Herpes Simplex:

(show top 50)    (show all 2659)
idTitleAuthorsYear
1
Tear HSV-specific secretory IgA as a potential indicator for recurrent stromal herpes simplex keratitis: a preliminary study. (23594767)
2013
2
Pitfalls associated with the diagnosis of herpes simplex encephalitis. (23914095)
2013
3
Herpes simplex virus encephalitis involving the right thalamus. (23784771)
2013
4
Rapid host immune response and viral dynamics in herpes simplex virus-2 infection. (23467247)
2013
5
Mode of virus rescue determines the acquisition of VHS mutations in VP22-negative herpes simplex virus 1. (23864617)
2013
6
Unusual concurrence of heterotopic glial nodule of the scalp and congenital herpes simplex virus type-2 infection. (23998268)
2013
7
Tin oxide nanowires suppress herpes simplex virus-1 entry and cell-to-cell membrane fusion. (23110193)
2012
8
Seroepidemiology of herpes simplex virus type 1 and 2 in northern iran. (23113228)
2012
9
Herpes simplex virus type 1 is the leading cause of genital herpes in New Brunswick. (23450274)
2012
10
Incidence of neonatal herpes simplex virus infections in the United States, 2006. (21149432)
2011
11
Acute disseminated encephalomyelitis following herpes simplex encephalitis. (21305866)
2010
12
What is your diagnosis? Acute herpes simplex virus type 1 stomatitis. (19445307)
2009
13
Effects of lamin A/C, lamin B1, and viral US3 kinase activity on viral infectivity, virion egress, and the targeting of herpes simplex virus U(L)34-encoded protein to the inner nuclear membrane. (18524819)
2008
14
Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes. (16501095)
2006
15
Herpes simplex virus 1 infection induces the expression of proinflammatory cytokines, interferons and TLR7 in human corneal epithelial cells. (16423052)
2006
16
Plasmacytoid dendritic cell reconstitution following bone marrow transplantation: subnormal recovery and functional deficit of IFN-alpha/beta production in response to herpes simplex virus. (15767787)
2005
17
Herpes simplex encephalitis and radiotherapy. (13679127)
2003
18
Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence. (11773369)
2002
19
Herpes simplex virus associated erythema multiforme in a prepartum woman without involvement of the newborn. (12428866)
2002
20
Patients with suspected herpes simplex encephalitis: rethinking an initial negative polymerase chain reaction result. (11915008)
2002
21
Inhibitory effect of sulfated galactans from the marine alga Bostrychia montagnei on herpes simplex virus replication in vitro. (11292240)
2001
22
Localization of the gD-binding region of the human herpes simplex virus receptor, HveA. (11119586)
2001
23
Herpes simplex virus glycoprotein D bound to the human receptor HveA. (11511370)
2001
24
Efficient cotransduction of tumors by multiple herpes simplex vectors: implications for tumor vaccine production. (10811476)
2000
25
Percutaneous gene therapy using recombinant adenoviruses encoding human herpes simplex virus thymidine kinase, human PAI-1, and human NOS3 in balloon-injured porcine coronary arteries. (10890742)
2000
26
Selective inhibition of herpes simplex virus type-1 uracil-DNA glycosylase by designed substrate analogs. (11084051)
2000
27
Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir. (10619751)
2000
28
Wild-type herpes simplex virus 1 blocks programmed cell death and release of cytochrome c but not the translocation of mitochondrial apoptosis-inducing factor to the nuclei of human embryonic lung fibroblasts. (10982349)
2000
29
Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription. (9621021)
1998
30
Application of competitive PCR to cerebrospinal fluid samples from patients with herpes simplex encephalitis. (9665997)
1998
31
Herpes simplex virus thymidine kinase-green fluorescent protein fusion gene: new tool for gene transfer studies and gene therapy. (9564534)
1998
32
Quantitation of herpes simplex virus DNA in cerebrospinal fluid of patients with herpes simplex encephalitis by the polymerase chain reaction. (9126688)
1997
33
Construction and characterization of herpes simplex virus type 1 mutants with conditional defects in immediate early gene expression. (9123865)
1997
34
Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. (8670825)
1996
35
Centripetal transport of herpes simplex virus in human retinal pigment epithelial cells in vitro. (8684617)
1996
36
Immunotherapy of acute and recurrent herpes simplex virus type 2 infection with an adjuvant-free form of recombinant glycoprotein D-interleukin-2 fusion protein. (8133093)
1994
37
The role of natural killer cells in the development of herpes simplex virus type 1 induced stromal keratitis in mice. (7958034)
1994
38
Polymerase chain reaction amplification of herpes simplex viral DNA from the geniculate ganglion of a patient with Bell's palsy. (7944168)
1994
39
In vitro effects of interleukin-2 and gamma globulin on immune dysfunction in a patient with severe mucocutaneous herpes simplex virus infection. (1371040)
1992
40
The herpes simplex virus immediate-early protein ICP27 stimulates the transcription of cellular Alu repeated sequences by increasing the activity of transcription factor TFIIIC. (1320373)
1992
41
Cooperative interactions between replication origin-bound molecules of herpes simplex virus origin-binding protein are mediated via the amino terminus of the protein. (1321142)
1992
42
Reverse crossed cerebellar diaschisis in partial complex seizures related to herpes simplex encephalitis. (1395348)
1992
43
A hypothesis on the pathophysiology of neonatal herpes simplex virus encephalitis: clinical recurrence after asymptomatic primary infection. (2352814)
1990
44
Neonatal herpes simplex viremia. (2839814)
1988
45
Diagnosis of acute herpes simplex encephalitis by brain perfusion single photon emission computed tomography. (2897007)
1988
46
The in vitro evaluation of nucleoside analogues as probes for use in the noninvasive diagnosis of herpes simplex encephalitis. (2855577)
1988
47
Probable herpes simplex virus type 1-related acute parotitis, nephritis and erythema multiforme. (2839815)
1988
48
Neonatal herpes simplex infection. (4000996)
1985
49
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. (6985228)
1982
50
Serologic investigations in narcotic addicts. I. Syphilis, lymphogranuloma venereum, herpes simplex, and Q fever. (5682247)
1968

Genetic Variations for Herpes Simplex

Expression for genes affiliated with Herpes Simplex

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Herpes Simplex

Search GEO for disease gene expression data for Herpes Simplex.

Pathways for genes affiliated with Herpes Simplex

Sources:
30KEGG, 54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 53R&D Systems, 4Cell Signaling Technology
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Pathways related to Herpes Simplex according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9EIF2AK2, PVRL1, PVRL2, TICAM1, TLR3, TNFRSF14
2
Hide members
11.6PVRL2, TICAM1, TLR3, TNFRSF14, UNC93B1, TRAF3
3
Hide members
11.1TLR3, TNFRSF14, CREB3, TRAF3
4
Hide members
11.1TICAM1, TLR3, CREB3, TRAF3
5
Hide members
11.1TICAM1, TLR3, UNC93B1, TRAF3
611.1TICAM1, TLR3, TRAF3, EIF2AK2
7
Hide members
10.9TRAF3, TLR3, TICAM1
8
Hide members
10.9TRAF3, TLR3, TICAM1
910.9TICAM1, TLR3, TRAF3
1010.8UNC93B1, TLR3
1110.8PVRL2, PVRL1
1210.8PVRL2, PVRL1

Compounds for genes affiliated with Herpes Simplex

Sources:
45Novoseek, 60Tocris Bioscience
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Compounds related to Herpes Simplex according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine4511.7PVRL2, TLR3, TRAF3, DARC, EIF2AK2, TKT
2poly(i-c)4511.0EIF2AK2, TICAM1, TLR3
3poly c4510.8EIF2AK2, TLR3
4rantes4510.7EIF2AK2, DARC
5tunicamycin45 6011.6CREB3, PPP1R15A, EIF2AK2

GO Terms for genes affiliated with Herpes Simplex

Sources:
16Gene Ontology
See all sources

Biological processes related to Herpes Simplex according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904811.7EIF2AK2, HCFC1, CREB3, TNFRSF14, PVRL2, PVRL1
2toll-like receptor 3 signaling pathwayGO:03413811.4TICAM1, TLR3, UNC93B1, TRAF3
3toll-like receptor signaling pathwayGO:00222411.4TICAM1, TLR3, UNC93B1, TRAF3
4defense response to virusGO:05160711.3TICAM1, TLR3, UNC93B1, EIF2AK2
5innate immune responseGO:04508711.2EIF2AK2, TRAF3, UNC93B1, TLR3, TICAM1
6positive regulation of interleukin-6 productionGO:03275511.2IL36G, TLR3, TICAM1
7inflammatory responseGO:00695411.2TICAM1, TLR3, IL36G, DARC
8TRIF-dependent toll-like receptor signaling pathwayGO:03566611.1TRAF3, TLR3, TICAM1
9MyD88-independent toll-like receptor signaling pathwayGO:00275611.1TICAM1, TLR3, TRAF3
10release from viral latencyGO:01904611.1HCFC1, CREB3
11toll-like receptor 4 signaling pathwayGO:03414211.1TRAF3, TLR3, TICAM1
12positive regulation of interferon-beta biosynthetic processGO:04535911.0TLR3, TICAM1
13positive regulation of chemokine biosynthetic processGO:04508011.0TICAM1, TLR3
14positive regulation of NF-kappaB transcription factor activityGO:05109210.8TICAM1, TLR3, EIF2AK2
15response to exogenous dsRNAGO:04333010.8TLR3, TICAM1
16positive regulation of chemokine productionGO:03272210.5EIF2AK2, TLR3

Molecular functions related to Herpes Simplex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coreceptor activityGO:01502610.8PVRL2, PVRL1
2virus receptor activityGO:00161810.6TNFRSF14, PVRL2, PVRL1

Products for genes affiliated with Herpes Simplex

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Herpes Simplex

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet