MCID: HRP006
MIFTS: 65

Herpes Simplex malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Herpes Simplex

Aliases & Descriptions for Herpes Simplex:

Name: Herpes Simplex 12 52 41 42 14
Herpesvirus Hominis Disease 12
Herpes Simplex Infections 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8566
ICD10 33 B00 B00.9
ICD9CM 35 054
MeSH 42 D006561
UMLS 69 C0019348

Summaries for Herpes Simplex

MedlinePlus : 41 herpes is an infection that is caused by a herpes simplex virus (hsv). oral herpes causes cold sores around the mouth or face. genital herpes affects the genitals, buttocks or anal area. genital herpes is a sexually transmitted disease (std). it affects the genitals, buttocks or anal area. other herpes infections can affect the eyes, skin, or other parts of the body. the virus can be dangerous in newborn babies or in people with weak immune systems. there are two types of hsv: hsv type 1 most commonly causes cold sores. it can also cause genital herpes. hsv type 2 is the usual cause of genital herpes, but it also can infect the mouth. hsv spreads through direct contact. some people have no symptoms. others get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. most people have outbreaks several times a year. over time, you get them less often. medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards based summary : Herpes Simplex, also known as herpesvirus hominis disease, is related to herpes simplex encephalitis and herpes simplex encephalitis 1, and has symptoms including fever, halitosis and pelvic pain. An important gene associated with Herpes Simplex is NECTIN1 (Nectin Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ganciclovir and Docosanol have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and brain, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A viral infectious disease that results_in_formation_of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person.

Wikipedia : 71 Herpes simplex is a viral disease caused by the herpes simplex virus. Infections are categorized based... more...

Related Diseases for Herpes Simplex

Diseases in the Herpes Simplex family:

Congenital Herpes Simplex

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 434)
id Related Disease Score Top Affiliating Genes
1 herpes simplex encephalitis 12.6
2 herpes simplex encephalitis 1 12.4
3 herpes simplex virus keratitis 12.3
4 herpes simplex encephalitis 2 12.3
5 herpes simplex encephalitis 3 12.3
6 congenital herpes simplex virus infection 12.3
7 herpes simplex encephalitic 6 12.2
8 herpes simplex encephalitis 7 12.2
9 eczema herpeticum 12.2
10 congenital herpes simplex 12.1
11 genital herpes 11.9
12 neonatal herpes 11.6
13 herpetic whitlow 11.4
14 mollaret meningitis 11.4
15 erythema multiforme 11.3
16 acute retinal necrosis syndrome 11.3
17 proctitis 11.3
18 cytomegalovirus infection 11.3
19 viral pneumonia 11.3
20 aphthous stomatitis 11.3
21 cytomegalic inclusion disease 11.2
22 encephalitis 11.0
23 hyper-ige recurrent infection syndrome, autosomal recessive 10.9
24 autoimmune lymphoproliferative syndrome, type iib 10.9
25 salivary gland disease 10.9
26 pseudomembranous conjunctivitis 10.9
27 herpetic gastritis 10.9
28 pudendal neuralgia 10.9
29 neurological consequences of cytomegalovirus infection 10.9
30 keratitis 10.7
31 stromal keratitis 10.4
32 retinitis 10.4
33 neuronitis 10.4
34 gaze palsy, horizontal, with progressive scoliosis 10.3 NECTIN1 NECTIN2 TNFRSF14
35 meningitis 10.3
36 heterochromia iridis 10.3 IRF3 TLR3 TRAF3
37 hepatitis 10.2
38 lichen amyloidosis 10.2 TAP1 TAP2
39 xeroderma pigmentosum, group a 10.2 EIF2AK2 IFNA1
40 hepatitis c virus 10.2 CD209 IFNA1 IRF3 TLR3
41 glioma 10.2
42 plantar fasciitis 10.2 CD209 IRF3 TLR3 TRAF3
43 trachoma 10.2 IRF3 PML TLR3
44 leukemia 10.2
45 cervicitis 10.2
46 pneumonia 10.2
47 endotheliitis 10.2
48 rheumatoid lung disease 10.2 EIF2AK2 IFNA1 IRF3 PML TLR3
49 gastroduodenitis 10.1 CD209 EIF2AK2 IFNA1 TLR3
50 embryonal carcinoma 10.1 C3 EIF2AK2 IFNA1 IRF3

Graphical network of the top 20 diseases related to Herpes Simplex:



Diseases related to Herpes Simplex

Symptoms & Phenotypes for Herpes Simplex

UMLS symptoms related to Herpes Simplex:


fever, halitosis, pelvic pain, pruritus, snoring

MGI Mouse Phenotypes related to Herpes Simplex:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 C3 EIF2AK2 PML POU2F1 TAP1 TAP2
2 immune system MP:0005387 9.7 C3 EIF2AK2 IRF3 PML TAP1 TAP2
3 mortality/aging MP:0010768 9.4 C3 CREB3 EIF2AK2 NECTIN1 PML POU2F1

Drugs & Therapeutics for Herpes Simplex

Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 228)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 1 82410-32-0 3454
2
Docosanol Approved, Investigational Phase 4 30303-65-2, 661-19-8 12620
3
Tenofovir Approved, Investigational Phase 4,Phase 3,Phase 1 147127-20-6 464205
4
Famciclovir Approved Phase 4,Phase 3,Phase 2 104227-87-4 3324
5
Penciclovir Approved Phase 4,Phase 3 39809-25-1 4725
6
Metronidazole Approved Phase 4 443-48-1 4173
7 Acyclovir Phase 4,Phase 3,Phase 2,Phase 1
8 valacyclovir Phase 4,Phase 3,Phase 2,Phase 1
9 Ganciclovir triphosphate Phase 4,Phase 2,Phase 1
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
13 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
14 Anti-HIV Agents Phase 4,Phase 3,Phase 1
15 2-Aminopurine Phase 4,Phase 3,Phase 2
16 Antimetabolites Phase 4,Phase 3,Phase 2
17 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
19 Antiparasitic Agents Phase 4
20 Antiprotozoal Agents Phase 4
21
Ethanol Approved Phase 3,Phase 2 64-17-5 702
22
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
23
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
24
Edetic Acid Approved, Vet_approved Phase 3,Phase 1 60-00-4, 62-33-9 6049
25
Zinc Approved Phase 3 7440-66-6 32051 23994
26
Melphalan Approved Phase 3 148-82-3 4053 460612
27
Glycerol Approved, Experimental Phase 3,Phase 1 56-81-5 753
28
Vidarabine Approved Phase 3 24356-66-9 32326 21704
29
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754 657311
30
Foscarnet Approved Phase 3,Phase 2,Phase 1 63585-09-1, 4428-95-9 3415
31
Halofantrine Approved Phase 3 69756-53-2 37393
32
Zanamivir Approved, Investigational Phase 3 139110-80-8 60855
33
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
34
Phosphonoacetic Acid Experimental Phase 3,Phase 2,Phase 1 4408-78-0 546
35
Butyric Acid Experimental Phase 3 107-92-6 264
36 Prednisolone acetate Phase 3
37 Gastrointestinal Agents Phase 3,Phase 1
38 Neuroprotective Agents Phase 3
39 Hormones Phase 3,Phase 2,Phase 1
40 Pentetic Acid Phase 3,Phase 1
41 Peripheral Nervous System Agents Phase 3,Phase 1
42 Prednisolone hemisuccinate Phase 3
43 5- ((2- (6- Amino- 9H- purin- 9- yl) ethyl) amino) - 1- pentanol Phase 3,Phase 2
44 Prednisolone phosphate Phase 3
45 Protective Agents Phase 3,Phase 2,Phase 1
46 Antiemetics Phase 3,Phase 1
47 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
48 Pulmonary Surfactants Phase 3
49 Methylprednisolone acetate Phase 3
50 Methylprednisolone Hemisuccinate Phase 3

Interventional clinical trials:

(show top 50) (show all 267)
id Name Status NCT ID Phase
1 Comparison of Topical Antiviral Agents for Labial Cold Sores (Herpes Labialis) Unknown status NCT00467662 Phase 4
2 Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding Completed NCT01448616 Phase 4
3 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4
4 A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. Completed NCT00158860 Phase 4
5 Palatability Testing of a New Paediatric Formulation of Valacyclovir Completed NCT01682109 Phase 4
6 Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV Completed NCT00527618 Phase 4
7 VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies. Completed NCT00116844 Phase 4
8 Valacyclovir Augmentation for Cognitive and Functional Remediation in Schizophrenia Completed NCT01794897 Phase 4
9 A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons Completed NCT00161434 Phase 4
10 Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT00362297 Phase 4
11 Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT01346475 Phase 4
12 A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation Completed NCT00723229 Phase 4
13 Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons Completed NCT01026454 Phase 4
14 A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand Completed NCT00362596 Phase 4
15 Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients Completed NCT00477334 Phase 4
16 A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding Completed NCT00129818 Phase 4
17 A Study to Evaluate the Safety and Efficacy of Single Day or Single Dose Famciclovir for the Treatment of Recurrent Herpes Labialis Completed NCT00248144 Phase 4
18 RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir Completed NCT00219310 Phase 4
19 VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2 Completed NCT00306293 Phase 4
20 A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers Completed NCT00820534 Phase 4
21 PTH - Preemptive Treatment for Herpesviridae Recruiting NCT02152358 Phase 4
22 Effect of HSV-2 Suppressive Therapy on Sexual Behavior Active, not recruiting NCT00495716 Phase 4
23 The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis Terminated NCT02045082 Phase 4
24 A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons Terminated NCT00079911 Phase 4
25 Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Involving the Central Nervous System Unknown status NCT00006132 Phase 3
26 A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients Unknown status NCT00005663 Phase 3
27 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3
28 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
29 NB-001 Treatment of Recurrent Herpes Labialis Unknown status NCT01695187 Phase 3
30 Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease Completed NCT00699764 Phase 3
31 Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects Completed NCT00698568 Phase 3
32 Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old Completed NCT00224484 Phase 3
33 Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth Completed NCT00031447 Phase 3
34 Study to Compare Safety and Immunogenicity of Commercial Scale Consistency Lots of Herpes Simplex Vaccine Completed NCT00224471 Phase 3
35 Open-label Study of ASP2151 in Herpes Simplex Patients Completed NCT02209324 Phase 3
36 Phase III Study of ASP2151 in Herpes Simplex Patients Completed NCT01959295 Phase 3
37 Valaciclovir to Prevent Transmission of Herpes Simplex Virus Completed NCT00001649 Phase 3
38 Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates Completed NCT00031460 Phase 3
39 Acyclovir in Preventing Herpes Simplex Virus Infection in Patients With Neutropenia Completed NCT00855309 Phase 3
40 Valaciclovir Hydrochloride Phase III for Hematopoietic Stem Cell Transplantation Patients Completed NCT01602562 Phase 3
41 Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection Completed NCT00098059 Phase 3
42 Long Term Treatment of Herpes Simplex Encephalitis (HSE) With Valacyclovir Completed NCT00031486 Phase 3
43 Zinc for the Treatment of Herpes Simplex Labialis (HSL) Completed NCT00809809 Phase 3
44 Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Limited to Skin, Eyes, and Mouth Completed NCT00006135 Phase 3
45 Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth Completed NCT00004757 Phase 3
46 HerpeVac Trial for Young Women Completed NCT00057330 Phase 3
47 Comparison of Foscarnet Versus Vidarabine in the Treatment of Herpes Infection in Patients With AIDS Who Have Not Had Success With Acyclovir Completed NCT00000985 Phase 3
48 Safety and Effectiveness of Tenofovir Gel in the Prevention of Human Immunodeficiency Virus (HIV-1) Infection in Women and the Effects of Tenofovir Gel on the Incidence of Herpes Simplex Virus (HSV-2) Infection Completed NCT01386294 Phase 3
49 Safety Study of ME-609 for Treatment of Herpes Simplex Labialis in Adolescents Completed NCT00375570 Phase 3
50 Efficacy and Safety Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis Completed NCT00361881 Phase 3

Search NIH Clinical Center for Herpes Simplex

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: herpes simplex

Genetic Tests for Herpes Simplex

Anatomical Context for Herpes Simplex

MalaCards organs/tissues related to Herpes Simplex:

39
Skin, Eye, Brain, T Cells, Lymph Node, Testes, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Herpes Simplex:

18
H, Mouth, Face, Genitalia

Publications for Herpes Simplex

Articles related to Herpes Simplex:

(show top 50) (show all 3010)
id Title Authors Year
1
Evaluation of Herpes Simplex Virus Type 2 Serological Tests for Use With Dried Blood Spots in Kenya. ( 28081046 )
2017
2
An Interleukin 12 Adjuvanted Herpes Simplex Virus 2 DNA Vaccine Is More Protective Than a Glycoprotein D Subunit Vaccine in a High-Dose Murine Challenge Model. ( 28085634 )
2017
3
Long-term Outcomes of Pediatric Penetrating Keratoplasty for Herpes Simplex Virus Keratitis. ( 27746299 )
2017
4
Vaccination to Reduce Reactivation of Herpes Simplex Virus 2. ( 28077729 )
2017
5
Pure word deafness due to herpes simplex encephalitis. ( 28017194 )
2017
6
Understanding the Role of Chemokines and Cytokines in Experimental Models of Herpes Simplex Keratitis. ( 28491875 )
2017
7
Induction of Multiple miR-200/182 Members in the Brains of Mice Are Associated with Acute Herpes Simplex Virus 1 Encephalitis. ( 28045967 )
2017
8
Association between herpes simplex virus Types 1 and 2 with cardiac myxoma. ( 28081512 )
2017
9
Exposure Stress Induces Reversible Corneal Graft Opacity in Recipients With Herpes Simplex Virus-1 Infections. ( 28055100 )
2017
10
Visualization of herpes simplex virus type 1 virions using fluorescent colors. ( 28012897 )
2017
11
Clinical Characteristics of Herpes Simplex Virus Urethritis Compared With Chlamydial Urethritis Among Men. ( 28079748 )
2017
12
Herpes Simplex Encephalitis Complicated by Cerebral Hemorrhage during Acyclovir Therapy. ( 28090058 )
2017
13
Subclinical Herpes Simplex Virus Type 1 Infections Provide Site-Specific Resistance to an Unrelated Pathogen. ( 28062697 )
2017
14
Herpes Simplex Encephalitis. ( 28076016 )
2017
15
Enrichment of herpes simplex virus type 2 (HSV-2) reactive mucosal T cells in the human female genital tract. ( 28051084 )
2017
16
Coexistence of herpes simplex virus infection in microsporidial stromal keratitis associated with granulomatous inflammation. ( 28513490 )
2017
17
Long-term outcomes of the Boston type I keratoprosthesis in eyes with previous herpes simplex virus keratitis. ( 28495905 )
2017
18
Incidence and mortality of herpes simplex encephalitis in Denmark: A nationwide registry-based cohort study. ( 27717782 )
2017
19
Lymphangiogenesis: a new player in herpes simplex virus 1-triggered T-cell response. ( 28044065 )
2017
20
Herpes Simplex Virus Keratitis and Resistance to Acyclovir. ( 28060081 )
2017
21
Herpes Simplex Virus 1 Abrogates cGAS/STING-Mediated Cytosolic DNA-sensing Pathway via Its Virion Host Shutoff Protein UL41. ( 28077645 )
2017
22
Initial Presentation of Neonatal Herpes Simplex Virus Infection. ( 26960921 )
2016
23
Collaboration with a midwife in the care of a pregnant patient with recurrent genital herpes simplex virus. ( 27412208 )
2016
24
Diagnostic Pathways as Social and Participatory Practices: The Case of Herpes Simplex Encephalitis. ( 26960197 )
2016
25
Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. ( 26937035 )
2016
26
Herpes simplex induced necrotizing tonsillitis in an immunocompromised patient with ulcerative colitis. ( 26881193 )
2016
27
Human herpesvirus-6 and herpes simplex virus-1 as a cause of cardiomyopathy secondary to myocarditis in children. ( 28008734 )
2016
28
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents. ( 27273328 )
2016
29
Herpes simplex infection on a recent tattoo. A new case of "herpes compuctorum". ( 27653017 )
2016
30
Ubiquitin-specific protease 9X in host cells interacts with herpes simplex virus 1 ICP0. ( 26596467 )
2016
31
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - comment. ( 27620850 )
2016
32
Can we differentiate between herpes simplex encephalitis and Japanese encephalitis? ( 27288787 )
2016
33
Temporal Lobe Encephalitis Need not Always be Herpes Simplex Encephalitis: Think of Tuberculosis. ( 27437274 )
2016
34
Infant Deaths Due To Herpes Simplex Virus, Congenital Syphilis, and HIV in New York City. ( 26933212 )
2016
35
Differences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis. ( 27817117 )
2016
36
Medroxyprogesterone acetate and levonorgestrel increase genital mucosal permeability and enhance susceptibility to genital herpes simplex virus type 2 infection. ( 27007679 )
2016
37
SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1. ( 27099310 )
2016
38
Herpes simplex virus type 2-associated recurrent aseptic meningitis (Mollaret's meningitis) with a recurrence after 11-year interval: a case report. ( 27773908 )
2016
39
Herpes Simplex Virus Type 1 Ubiquitin-specific Protease UL36 abrogates NF-I_B Activation in DNA Sensing Signal Pathway. ( 28031360 )
2016
40
Improvement in detrusor-sphincter dyssynergia by bladder-wall injection of replication-defective herpes simplex virus vector-mediated gene delivery of kynurenine aminotransferase II in spinal cord injury rats. ( 27995942 )
2016
41
Herpes simplex virus type 2: Cluster of unrelated cases in an intensive care unit. ( 27198455 )
2016
42
Development of Herpes Simplex Virus Infectious Epithelial Keratitis During Oral Acyclovir Therapy and Response to Topical Antivirals. ( 26989961 )
2016
43
Autoimmune Post-Herpes Simplex Encephalitis. ( 27396274 )
2016
44
Herpes simplex encephalitis as a complication of neurosurgical procedures: report of 3 cases and review of the literature. ( 27216026 )
2016
45
I^134.5 neurovirulence gene of herpes simplex virus type 1 modifies the exosome secretion profile in epithelial cells. ( 27630235 )
2016
46
Poster 215 Gustatory Agnosia Following Herpes Simplex Virus Encephalitis: A Case Report. ( 27672976 )
2016
47
Nosocomial herpes simplex encephalitis: A challenging diagnosis. ( 27686257 )
2016
48
Interleukin-27 Inhibits Herpes Simplex Virus Type 1 Infection by Activating STAT1 and 3, Interleukin-6, and Chemokines IP-10 and MIG. ( 27617644 )
2016
49
Herpes simplex virus and the lexicon of latency and reactivation: a call for defining terms and building an integrated collective framework. ( 27610228 )
2016
50
Cutaneous neonatal herpes simplex virus infection type 2: a case report. ( 27192523 )
2016

Variations for Herpes Simplex

Expression for Herpes Simplex

LifeMap Discovery
Genes differentially expressed in tissues of Herpes Simplex patients vs. healthy controls: 35
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 FCN1 ficolin (collagen/fibrinogen domain containing) 1 Skin + 3.89 0.000
2 IRF1 interferon regulatory factor 1 Skin + 3.58 0.000
3 STAT1 signal transducer and activator of transcription 1, 91kDa Skin + 3.53 0.000
4 RARRES3 retinoic acid receptor responder (tazarotene induced) 3 Skin + 3.49 0.000
5 SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 Skin + 3.41 0.000
6 CCL19 chemokine (C-C motif) ligand 19 Skin + 3.32 0.003
7 XAF1 XIAP associated factor 1 Skin + 3.04 0.000
Search GEO for disease gene expression data for Herpes Simplex.

Pathways for Herpes Simplex

Pathways related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 C3 CD209 EIF2AK2 IFI16 IFNA1 IRF3
2
Show member pathways
13.17 EIF2AK2 IFNA1 IRF3 PML POU2F1 TNFRSF14
3
Show member pathways
12.81 CD209 IFI16 IFNA1 IRF3 TLR3 TLR9
4
Show member pathways
12.72 C3 CREB3 IFNA1 IRF3 TLR3 TLR9
5
Show member pathways
12.49 CREB3 EIF2AK2 PML TBP TRAF3
6
Show member pathways
12.4 CREB3 IRF3 TLR3 TLR9 TNFRSF14 TNFSF14
7
Show member pathways
12.36 EIF2AK2 IFNA1 IRF3 PML
8
Show member pathways
12.24 C3 CD209 EIF2AK2 HCFC1 IFNA1 IRF3
9 12.16 EIF2AK2 IRF3 TBP TRAF3
10
Show member pathways
12.12 IRF3 TLR3 TLR9 TRAF3
11 12.06 C3 CD209 IFNA1 TLR9
12 12.05 IFI16 IFNA1 IRF3 TAP1 TAP2 TLR3
13 12.04 C3 CREB3 EIF2AK2 IRF3 TBP TRAF3
14 11.96 C3 CD209 TAP1 TAP2
15 11.88 EIF2AK2 IFNA1 IRF3 TLR3 TRAF3
16 11.66 C3 TLR3 TLR9
17 11.47 NECTIN2 TNFRSF14 TNFSF14

GO Terms for Herpes Simplex

Cellular components related to Herpes Simplex according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.87 CREB3 PML POU2F1 TAP1 TAP2 TLR3
2 endoplasmic reticulum membrane GO:0005789 9.85 CREB3 PML TAP1 TAP2 TLR3 TLR9
3 cell-cell contact zone GO:0044291 9.4 NECTIN1 NECTIN2
4 apical junction complex GO:0043296 9.26 NECTIN1 NECTIN2
5 endolysosome membrane GO:0036020 9.16 TLR3 TLR9
6 host cell GO:0043657 8.96 TAP1 TAP2
7 TAP complex GO:0042825 8.62 TAP1 TAP2

Biological processes related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.92 CD209 IFNA1 TAP1 TAP2
2 innate immune response GO:0045087 9.85 C3 CD209 EIF2AK2 IFI16 IFNA1 IRF3
3 positive regulation of type I interferon production GO:0032481 9.77 IFI16 IRF3 TLR3
4 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.74 CD209 NECTIN1 NECTIN2
5 defense response to virus GO:0051607 9.73 EIF2AK2 IFI16 IFNA1 IRF3 PML TLR3
6 toll-like receptor signaling pathway GO:0002224 9.72 TLR3 TLR9 TRAF3
7 immune system process GO:0002376 9.7 C3 CD209 EIF2AK2 IFI16 IRF3 PML
8 response to exogenous dsRNA GO:0043330 9.69 IFNA1 IRF3 TLR3
9 viral entry into host cell GO:0046718 9.67 CD209 NECTIN1 NECTIN2 TNFRSF14
10 positive regulation of cytokine production GO:0001819 9.65 EIF2AK2 IFI16 TLR3
11 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.64 TLR3 TLR9
12 I-kappaB phosphorylation GO:0007252 9.63 TLR3 TLR9
13 peptide transport GO:0015833 9.63 TAP1 TAP2
14 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.63 IRF3 TLR3 TRAF3
15 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.62 TAP1 TAP2
16 positive regulation of interferon-beta biosynthetic process GO:0045359 9.61 TLR3 TLR9
17 positive regulation of interferon-beta production GO:0032728 9.61 IRF3 TLR3 TLR9
18 cellular response to dsRNA GO:0071359 9.58 IRF3 TLR3
19 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.58 TAP1 TAP2
20 intracellular transport of viral protein in host cell GO:0019060 9.56 TAP1 TAP2
21 positive regulation of toll-like receptor signaling pathway GO:0034123 9.54 TLR3 TLR9
22 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.52 TLR3 TLR9
23 positive regulation of chemokine production GO:0032722 9.5 EIF2AK2 TLR3 TLR9
24 peptide antigen transport GO:0046968 9.49 CD209 TAP2
25 cytosol to ER transport GO:0046967 9.4 TAP1 TAP2
26 viral process GO:0016032 9.4 CD209 CREB3 EIF2AK2 HCFC1 IRF3 NECTIN1
27 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.14 CREB3 HCFC1 IFI16 PML POU2F1 TLR3
28 inflammatory response GO:0006954 10 C3 IFI16 TLR3 TLR9 TNFRSF14

Molecular functions related to Herpes Simplex according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.91 IRF3 NECTIN1 NECTIN2 PML TAP1 TLR9
2 protein binding GO:0005515 9.91 C3 CD209 CREB3 EIF2AK2 HCFC1 IFI16
3 virion binding GO:0046790 9.46 CD209 NECTIN1
4 MHC protein binding GO:0042287 9.4 TAP1 TAP2
5 peptide-transporting ATPase activity GO:0015440 9.37 TAP1 TAP2
6 TAP1 binding GO:0046978 9.32 TAP1 TAP2
7 peptide transporter activity GO:0015197 9.26 TAP1 TAP2
8 MHC class Ib protein binding GO:0023029 9.16 TAP1 TAP2
9 virus receptor activity GO:0001618 8.92 CD209 NECTIN1 NECTIN2 TNFRSF14

Sources for Herpes Simplex

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....