MCID: HRP006
MIFTS: 66

Herpes Simplex malady

Oral diseases, Reproductive diseases, Rare diseases categories

Summaries for Herpes Simplex

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MedlinePlus:34 Herpes is an infection that is caused by a herpes simplex virus (hsv). oral herpes causes cold sores around the mouth or face. genital herpes affects the genitals, buttocks or anal area. genital herpes is a sexually transmitted disease (std). it affects the genitals, buttocks or anal area. other herpes infections can affect the eyes, skin, or other parts of the body. the virus can be dangerous in newborn babies or in people with weak immune systems. there are two types of hsv: hsv type 1 most commonly causes cold sores. it can also cause genital herpes. hsv type 2 is the usual cause of genital herpes, but it also can infect the mouth. hsv spreads through direct contact. some people have no symptoms. others get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. most people have outbreaks several times a year. over time, you get them less often. medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards based summary: Herpes Simplex, also known as herpesvirus hominis disease, is related to encephalitis and genital herpes. An important gene associated with Herpes Simplex is UNC93B1 (unc-93 homolog B1 (C. elegans)), and among its related pathways are Trafficking and processing of endosomal TLR and Nectin adhesion pathway. The drugs benzocaine and methylene blue and the compounds inosine monophosphate and poly(i-c) have been mentioned in the context of this disorder. Affiliated tissues include mouth, face and genitalia, and related mouse phenotypes are liver/biliary system and immune system.

Disease Ontology:10 A viral infectious disease that results in formation of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia:65 Herpes simplex (Greek: ????? herp?s, \"creeping\" or \"latent\") is a viral disease caused by the herpes... more...

Aliases & Classifications for Herpes Simplex

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Herpes Simplex, Aliases & Descriptions:

Name: Herpes Simplex 10 12 45 34
Herpesvirus Hominis Disease 10 62
 
Herpes Simplex Infections 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Oral diseases, Reproductive diseases


External Ids:

Disease Ontology10 DOID:8566
MeSH35 D006561
ICD9CM29 054

Related Diseases for Herpes Simplex

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Graphical network of the top 20 diseases related to Herpes Simplex:



Diseases related to herpes simplex

Symptoms for Herpes Simplex

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Drugs & Therapeutics for Herpes Simplex

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Genetic Tests for Herpes Simplex

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Anatomical Context for Herpes Simplex

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MalaCards organs/tissues related to Herpes Simplex:

33
Skin, Eye, Brain, T cells, Lymph node, Liver, Testes, Endothelial, Lung, Breast, Prostate, Monocytes, B cells, Temporal lobe, Bone, Colon, Bone marrow, Thyroid, Nk cells, Cortex, Heart, Myeloid, Trigeminal ganglion, Tongue, Dorsal root ganglion, Whole blood, Thymus, Spinal cord, Kidney, Pancreas, Ovary, Placenta, Cervix, Tonsil, Thalamus, Pituitary

FMA organs/tissues related to Herpes Simplex:

16
Mouth, Face, Genitalia, H

Animal Models for Herpes Simplex or affiliated genes

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MGI Mouse Phenotypes related to Herpes Simplex:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.5TRAF3, TKT, TBK1, TICAM1, UNC93B1
2MP:00053879.3TLR3, UNC93B1, TNFRSF14, TICAM1, TBK1, TRAF3
3MP:00053768.8DARC, TLR3, UNC93B1, TNFRSF14, TICAM1, PVRL1

Publications for Herpes Simplex

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Articles related to Herpes Simplex:

(show top 50)    (show all 2737)
idTitleAuthorsYear
1
The Us3 Protein of Herpes Simplex Virus 1 Inhibits T Cell Signaling by Confining LAT Activation via TRAF6. (25907557)
2015
2
Burning mouth syndrome due to herpes simplex virus type 1. (25833911)
2015
3
Tomato thymidine kinase-based suicide gene therapy for malignant glioma-an alternative for Herpes Simplex virus-1 thymidine kinase. (25613481)
2015
4
Comparison of the ocular characteristics of anterior uveitis caused by herpes simplex virus, varicella-zoster virus, and cytomegalovirus. (25124341)
2014
5
Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum. (24559566)
2014
6
Acute herpes simplex encephalitis in pregnancy. (25546520)
2014
7
I^-Amyloid peptides display protective activity against the human Alzheimer's disease-associated herpes simplex virus-1. (25376108)
2014
8
Teaching NeuroImages: Infantile herpes simplex encephalitis. (25114204)
2014
9
Methods for screening and profiling inhibitors of herpes simplex viruses. (23821277)
2013
10
Herpes simplex encephalitis presenting with normal CSF analysis. (24169394)
2013
11
Herpes Simplex epithelial keratitis associated with daily disposable contact lens wear. (24333040)
2013
12
Immunological control of herpes simplex virus infections. (23943467)
2013
13
Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes. (24101547)
2013
14
Postpartum herpes simplex virus endometritis and disseminated infection in both mother and neonate. (22825269)
2012
15
Herpes simplex virus antigens directly activate NK cells via TLR2, thus facilitating their presentation to CD4 T lymphocytes. (22467654)
2012
16
Herpes simplex encephalitis presenting after steroid treatment of panuveitis. (21770880)
2011
17
Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo. (21632763)
2011
18
Auditory and vestibular defects induced by experimental labyrinthitis following herpes simplex virus in mice. (21526906)
2011
19
Gianotti-Crosti syndrome associated with herpes simplex virus type 1 gingivostomatitis. (21238841)
2011
20
New-onset herpes simplex virus keratitis after cataract surgery. (19092420)
2009
21
Delivery of Interferon-gamma by an adenovirus vector blocks herpes simplex virus Type 1 reactivation in vitro and in vivo independent of RNase L and double-stranded RNA-dependent protein kinase pathways. (19042034)
2009
22
Comparison of nested-polymerase chain reaction and virus culture for the diagnosis of genital herpes simplex virus infection. (18581019)
2008
23
Chronic sequelae of herpes simplex encephalitis demonstrated on interictal F-18 FDG PET/CT. (18496462)
2008
24
Immunohistochemical expression of p16 and herpes simplex virus type 2 in squamous intraepithelial lesions and cervical cancer]. (19142477)
2008
25
Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. (17267483)
2007
26
Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. (17085599)
2006
27
Consequences of chemoresistance for the herpes simplex virus thymidine kinase/ganciclovir-induced bystander effect in a human small cell lung cancer cell line model. (15816546)
2005
28
Potential nectin-1 binding site on herpes simplex virus glycoprotein d. (15613355)
2005
29
Plasmacytoid dendritic cell reconstitution following bone marrow transplantation: subnormal recovery and functional deficit of IFN-alpha/beta production in response to herpes simplex virus. (15767787)
2005
30
ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export. (15767397)
2005
31
Recurrent herpes simplex type 2 virus (Mollaret) meningitis. (15243021)
2004
32
Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies virus entry. (12072519)
2002
33
Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation. (12414939)
2002
34
Transverse myelitis associated with herpes simplex virus infection. (11732777)
2001
35
Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations-relevance for the incidence of genital herpes. (10797375)
2000
36
Lower interleukin-2 and higher serum tumor necrosis factor-a levels are associated with perimenstrual, recurrent, facial Herpes simplex infection in young women. (11022124)
2000
37
Classification of herpes simplex virus keratitis and anterior uveitis. (10090358)
1999
38
Identification of phosphorylation sites within the herpes simplex virus tegument protein VP22. (10364384)
1999
39
Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells. (9032307)
1997
40
High interferon alpha levels in placenta, maternal, and cord blood suggest a protective effect against intrauterine herpes simplex virus infection. (9139085)
1997
41
Inhibition of herpes simplex virus type 1 immediate-early gene expression by alpha interferon is not VP16 specific. (8709261)
1996
42
Intranasal immunization against herpes simplex virus infection by using a recombinant glycoprotein D fused with immunomodulating proteins, the B subunit of Escherichia coli heat-labile enterotoxin and interleukin-2. (8388365)
1993
43
Purification and characterization of the herpes simplex virus type 2-encoded uracil-DNA glycosylase. (8393229)
1993
44
Intra-uterine and neonatal herpes simplex virus infection. (1803497)
1991
45
Induction of encephalitis in SJL mice by intranasal infection with herpes simplex virus type 1: a possible model of herpes simplex encephalitis in humans. (1849158)
1991
46
Recurrent herpetic keratitis: failure to detect herpes simplex virus infection using the Syva MicroTrak HSV1/HSV2 direct specimen identification/typing test. (1963928)
1990
47
Neonatal herpes simplex viremia. (2839814)
1988
48
Non-herpes simplex encephalitis is early exclusion of herpes simplex etiology possible? (2824204)
1987
49
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. (6985228)
1982
50
Antiviral chemotherapy and neonatal herpes simplex virus infecition: a pilot study--experience with adenine arabinoside (ARA-A). (165453)
1975

Variations for Herpes Simplex

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Expression for genes affiliated with Herpes Simplex

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LifeMap Discovery
Genes differentially expressed in tissues of Herpes Simplex patients vs. healthy controls: 32 (show all 35)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1EIF3Heukaryotic translation initiation factor 3, subunit HLiver+4.390.000
2C9complement component 9Liver-4.360.000
3PSPHphosphoserine phosphataseBrain-4.350.000
4UBDubiquitin DLiver+3.390.000
5PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 6Liver+3.230.000
6GRAMD1CGRAM domain containing 1CLiver+2.700.000
7PSORS1C1psoriasis susceptibility 1 candidate 1Liver+2.560.000
8ADMadrenomedullinBrain-2.550.044
9SPAG7sperm associated antigen 7Liver+2.420.000
10UBFD1ubiquitin family domain containing 1Liver+2.360.000
11SPARCsecreted protein, acidic, cysteine-rich (osteonectin)Liver+2.350.000
12PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunitLiver+2.290.000
13DDIT4DNA-damage-inducible transcript 4Liver+2.270.000
14NDFIP2Nedd4 family interacting protein 2Liver+2.220.000
15TNFSF10tumor necrosis factor (ligand) superfamily, member 10Brain+2.190.003
16FUSfused in sarcomaLiver+2.160.000
17PIP4K2Aphosphatidylinositol-5-phosphate 4-kinase, type II, alphaLiver+2.150.000
18CSTBcystatin B (stefin B)Liver+2.100.000
19TUBB4Atubulin, beta 4A class IVaLiver+2.060.000
20EIF4Beukaryotic translation initiation factor 4BLiver+2.040.000
21CCDC62coiled-coil domain containing 62Liver+1.990.000
22ACANaggrecanLiver+1.960.000
23ZNF880zinc finger protein 880Brain-1.930.009
24RANRAN, member RAS oncogene familyLiver+1.910.000
25NPTX2neuronal pentraxin IIBrain-1.910.024
26NETO1neuropilin (NRP) and tolloid (TLL)-like 1Blood+1.800.025
27DDIT4DNA-damage-inducible transcript 4Brain-1.780.006
28SLC19A1solute carrier family 19 (folate transporter), member 1Blood+1.740.048
29OCLNoccludinBrain+1.650.003
30HOXB6homeobox B6Blood+1.620.048
31ALDH8A1aldehyde dehydrogenase 8 family, member A1Brain+1.600.047
32TMPRSS5transmembrane protease, serine 5Brain-1.600.023
33FKBP5FK506 binding protein 5Brain-1.570.046
34SOX18SRY (sex determining region Y)-box 18Brain+1.370.034
35TYW1tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)Brain+1.310.018


Search GEO for disease gene expression data for Herpes Simplex.

Pathways for genes affiliated with Herpes Simplex

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Pathways related to Herpes Simplex according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2UNC93B1, TLR3
210.1PVRL2, PVRL1
3
Show member pathways
10.0TBK1, TNFRSF14, TLR3
4
Show member pathways
10.0CREB3, TBK1, TRAF3
5
Show member pathways
9.9TLR3, TICAM1, TBK1
69.8TRAF3, TBK1, TICAM1, TLR3
7
Show member pathways
9.8TLR3, TICAM1, TBK1, TRAF3
89.8TLR3, TICAM1, TBK1, TRAF3
9
Show member pathways
9.6TLR3, TNFRSF14, CREB3, TBK1, TRAF3
10
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.6TLR3, TICAM1, CREB3, TBK1, TRAF3
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.5TRAF3, TBK1, IL36G, TICAM1, TLR3
12
Show member pathways
8.8TRAF3, TLR3, HCFC2, HCFC1, TNFRSF14, TICAM1

Compounds for genes affiliated with Herpes Simplex

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Sources:
45Novoseek, 26HMDB
See all sources

Compounds related to Herpes Simplex according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1inosine monophosphate4510.1TBK1, TLR3
2poly(i-c)459.9TLR3, TICAM1, TBK1
3rantes459.6TBK1, TICAM1, TLR3, DARC
4heparan sulfate45 2610.6PVRL1, PVRL2, GGH
5tyrosine458.9TRAF3, TKT, TBK1, AAVS1, PVRL2, PVRL1

GO Terms for genes affiliated with Herpes Simplex

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Cellular components related to Herpes Simplex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:00100089.8TBK1, TICAM1, TLR3
2Golgi membraneGO:00001399.4TLR3, UNC93B1, HS3ST4, CREB3
3cytosolGO:00058299.1TICAM1, CREB3, TBK1, GGH, TKT, TRAF3

Biological processes related to Herpes Simplex according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1release from viral latencyGO:001904610.5CREB3, HCFC1
2positive regulation of chemokine biosynthetic processGO:004508010.4TLR3, TICAM1
3tumor necrosis factor-mediated signaling pathwayGO:003320910.3TRAF3, TNFRSF14
4positive regulation of interferon-beta productionGO:003272810.3TLR3, TBK1
5positive regulation of interferon-beta biosynthetic processGO:004535910.3TBK1, TICAM1, TLR3
6I-kappaB kinase/NF-kappaB signalingGO:000724910.2TBK1, TICAM1, TLR3
7negative regulation of type I interferon productionGO:003248010.2TBK1, TRAF3
8positive regulation of interleukin-6 productionGO:003275510.2IL36G, TICAM1, TLR3
9positive regulation of I-kappaB kinase/NF-kappaB signalingGO:004312310.1TBK1, TICAM1, TLR3
10response to exogenous dsRNAGO:004333010.1TICAM1, TLR3
11TRIF-dependent toll-like receptor signaling pathwayGO:003566610.1TLR3, TICAM1, TBK1, TRAF3
12adherens junction organizationGO:003433210.1PVRL2, PVRL1
13MyD88-independent toll-like receptor signaling pathwayGO:000275610.1TLR3, TICAM1, TBK1, TRAF3
14defense response to virusGO:005160710.1TLR3, UNC93B1, TICAM1, TBK1
15toll-like receptor 4 signaling pathwayGO:003414210.1TRAF3, TBK1, TICAM1, TLR3
16defense response to Gram-positive bacteriumGO:005083010.0TNFRSF14, TBK1
17toll-like receptor 3 signaling pathwayGO:003413810.0TRAF3, TBK1, TICAM1, UNC93B1, TLR3
18toll-like receptor signaling pathwayGO:000222410.0TLR3, UNC93B1, TICAM1, TBK1, TRAF3
19innate immune responseGO:00450879.9TLR3, UNC93B1, TICAM1, TBK1, TRAF3
20viral processGO:00160329.8HCFC2, TNFRSF14, CREB3, TBK1
21positive regulation of tumor necrosis factor productionGO:00327609.8TICAM1, TLR3
22inflammatory responseGO:00069549.8DARC, TLR3, TICAM1, IL36G, TBK1

Molecular functions related to Herpes Simplex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coreceptor activityGO:001502610.1PVRL2, PVRL1
2virus receptor activityGO:000161810.0PVRL2, PVRL1, TNFRSF14
3cell adhesion molecule bindingGO:00508399.8PVRL1, PVRL2
4protein homodimerization activityGO:00428039.7TKT, CREB3, PVRL2, PVRL1
5protein bindingGO:00055158.5TICAM1, TNFRSF14, HCFC1, TLR3, PVRL1, PVRL2

Products for genes affiliated with Herpes Simplex

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  • Antibodies
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Sources for Herpes Simplex

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet