MCID: HRP006
MIFTS: 63

Herpes Simplex malady

Summaries for Herpes Simplex

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Herpes is an infection that is caused by a herpes simplex virus (hsv). oral herpes causes cold sores around the mouth or face. genital herpes affects the genitals, buttocks or anal area. genital herpes is a sexually transmitted disease (std). it affects the genitals, buttocks or anal area. other herpes infections can affect the eyes, skin, or other parts of the body. the virus can be dangerous in newborn babies or in people with weak immune systems. there are two types of hsv: hsv type 1 most commonly causes cold sores. it can also cause genital herpes. hsv type 2 is the usual cause of genital herpes, but it also can infect the mouth. hsv spreads through direct contact. some people have no symptoms. others get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. most people have outbreaks several times a year. over time, you get them less often. medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards: Herpes Simplex, also known as herpesvirus hominis disease, is related to encephalitis and hepatitis. An important gene associated with Herpes Simplex is TNFRSF14 (tumor necrosis factor receptor superfamily, member 14), and among its related pathways are Influenza A and Immune System. The drugs benzocaine and methylene blue and the compounds tyrosine and poly(i-c) have been mentioned in the context of this disorder. Affiliated tissues include h, genitalia and face.

Disease Ontology:8 A viral infectious disease that results in formation of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia:63 Herpes simplex (Greek: ἕρπης herpēs, \"creeping\" or \"latent\") is a viral disease from the... more...

Aliases & Classifications for Herpes Simplex

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

herpes simplex 8 10 44 33
herpesvirus hominis disease 8
herpes simplex infections 60


External Ids:

Disease Ontology8 DOID:8566
MeSH34 D006561
ICD9CM27 054

Related Diseases for Herpes Simplex

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Herpes Simplex:



Diseases related to herpes simplex

Clinical Features for Herpes Simplex

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Drugs & Therapeutics for Herpes Simplex

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Herpes Simplex

Drug clinical trials:

Search ClinicalTrials for Herpes Simplex

Search NIH Clinical Center for Herpes Simplex

Search CenterWatch for Herpes Simplex

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Herpes Simplex

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Anatomical Context for Herpes Simplex

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Herpes Simplex:

32
Skin, T cells, Eye, Brain, Testes, Liver, Endothelial, Lung, Breast, Prostate, Monocytes, B cells, Temporal lobe, Bone, Colon, Bone marrow, Thyroid, Nk cells, Tongue, Myeloid, Trigeminal ganglion, Cortex, Heart, Dorsal root ganglion, Tonsil, Thalamus, Cervix, Placenta, Whole blood, Lymph node, Thymus, Spinal cord, Kidney, Pancreas, Pituitary, Ovary

FMA organs/tissues related to Herpes Simplex:

14
H, Genitalia, Face, Mouth

Animal Models for Herpes Simplex or affiliated genes

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Publications for Herpes Simplex

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50PubMed
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Articles related to Herpes Simplex:

(show top 50)    (show all 2652)
idTitleAuthorsYear
1
Seroprevalence of herpes simplex virus types 1 and 2--United States, 1999-2010. (24136792)
2014
2
Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis. (24370835)
2013
3
In vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2. (23161023)
2013
4
Small non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival. (23648811)
2013
5
Novel deletion in glycoprotein G forms a cluster and causes epidemiologic spread of herpes simplex virus type 2 infection. (23861013)
2013
6
In-hospital herpes simplex encephalitis after open heart surgery: an emerging pathology or an under-recognised condition? (23845676)
2013
7
Herpes simplex virus 2-induced activation in vaginal cells involves Toll-like receptors 2 and 9 and DNA sensors DAI andA IFI16. (24080302)
2013
8
Confusion Secondary to Herpes Simplex Infection. (24022253)
2013
9
Empiric acyclovir for neonatal herpes simplex virus infection. (21992471)
2012
10
Prevalence of herpes simplex, Epstein Barr and human papilloma viruses in oral lichen planus. (21196875)
2011
11
HPV-73- and HPV-82 positive anal margin carcinoma with secondary ulcerating Herpes simplex-virus 2 infection. (21143394)
2011
12
A successfully treated case of herpes simplex encephalitis complicated by subarachnoid bleeding: a case report. (20860812)
2010
13
Herpes simplex virus type 1 ICP27 induces p38 mitogen-activated protein kinase signaling and apoptosis in HeLa cells. (19073744)
2009
14
Acyclovir susceptibility and genetic characteristics of sequential herpes simplex virus type 1 corneal isolates from patients with recurrent herpetic keratitis. (19795980)
2009
15
ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells. (19706544)
2009
16
Herpes simplex virus keratitis: histopathologic neovascularization and corneal allograft failure. (19724220)
2009
17
Unusual progression of herpes simplex encephalitis with basal ganglia and extensive white matter involvement. (21577367)
2009
18
Traffic of leukocytes in the central nervous system is associated with chemokine up-regulation in a severe model of herpes simplex encephalitis: an intravital microscopy study. (18782601)
2008
19
Herpes simplex encephalitis after craniopharyngioma surgery. (18976107)
2008
20
Rebamipide affects the efficiency of colchicine for the herpes simplex virus-induced inflammation in a Behcet's disease mouse model. (18823974)
2008
21
A comparative study of uracil-DNA glycosylases from human and herpes simplex virus type 1. (16306042)
2006
22
Role for 3-O-sulfated heparan sulfate as the receptor for herpes simplex virus type 1 entry into primary human corneal fibroblasts. (16940509)
2006
23
Contribution of cysteine residues to the structure and function of herpes simplex virus gH/gL. (15680420)
2005
24
Chondroitin sulfate characterized by the E-disaccharide unit is a potent inhibitor of herpes simplex virus infectivity and provides the virus binding sites on gro2C cells. (16027159)
2005
25
Acute intracerebral haematoma--an unusual presentation of herpes simplex encephalitis. (15633725)
2004
26
Neonatal genital herpes simplex virus type 1 infection after Jewish ritual circumcision: modern medicine and religious tradition. (15286266)
2004
27
Detection of herpes simplex virus genomic DNA in various subsets of Erythema multiforme by polymerase chain reaction. (14657624)
2003
28
Relapsing herpes simplex encephalitis: pathological confirmation of viral reactivation. (12531966)
2003
29
Aborted genital herpes simplex virus lesions: findings from a randomised controlled trial with valaciclovir. (12473805)
2002
30
Neonatal herpes simplex virus infection: A devastating newborn pathogen. (20046269)
2002
31
Projection of the future dimensions and costs of the genital herpes simplex type 2 epidemic in the United States. (12370529)
2002
32
Neonatal herpes simplex and incontinentia pigmenti. (11207986)
2001
33
Screening and treatment of sexually transmitted diseases Part 2: trichomonas, human papillomavirus infection, and genital herpes simplex virus. (10823973)
2000
34
Identification of phosphorylation sites within the herpes simplex virus tegument protein VP22. (10364384)
1999
35
Distinct responses of the herpes simplex virus and varicella zoster virus immediate early promoters to the cellular transcription factors Brn-3a and Brn-3b. (10224669)
1999
36
Retinal vasculitis with a frosted branch angiitis-like response due to herpes simplex virus type 2. (10546946)
1999
37
Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2. (10196288)
1999
38
Relapse and movement disorder after herpes simplex encephalitis. (9203073)
1997
39
Transcriptional targeting of herpes simplex virus for cell-specific replication. (9188579)
1997
40
Effect of antibody alone and combined with acyclovir on neonatal herpes simplex virus infection in guinea pigs. (8537645)
1996
41
A polymerase chain reaction assay of cerebrospinal fluid in patients with suspected herpes simplex encephalitis. (8389398)
1993
42
Herpes simplex virus infection selectively stimulates accumulation of beta interferon reporter gene mRNA by a posttranscriptional mechanism. (1316484)
1992
43
Intra-uterine and neonatal herpes simplex virus infection. (1803497)
1991
44
Herpes simplex virus type-1-induced stimulation of ribosomal protein S6 phosphorylation is inhibited in neomycin-treated human epidermoid carcinoma 2 cells and in ras-transformed cells. (2174778)
1990
45
Hyperammonemia and neonatal herpes simplex pneumonitis. (2235152)
1990
46
Neonatal herpes simplex pneumonitis. (3287569)
1988
47
No, brain biopsy need not be done in every patient suspected of having herpes simplex encephalitis. (3675262)
1987
48
Herpes simplex encephalitis in third trimester of pregnancy: successful outcome for mother and child. (3627453)
1987
49
Neonatal herpes simplex pneumonia: radiographic findings. (6484171)
1984
50
Visceral involvement by herpes simplex virus in eczema herpeticum. (4300208)
1968

Genetic Variations for Herpes Simplex

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Expression for genes affiliated with Herpes Simplex

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Herpes Simplex

Search GEO for disease gene expression data for Herpes Simplex.

Pathways for genes affiliated with Herpes Simplex

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29KEGG, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 4Cell Signaling Technology
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Pathways related to Herpes Simplex according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9EIF2AK2, PVRL1, PVRL2, TICAM1, TLR3, TNFRSF14
2
Hide members
11.6PVRL2, TICAM1, TLR3, TNFRSF14, UNC93B1, TRAF3
3
Hide members
11.1TLR3, TNFRSF14, CREB3, TRAF3
4
Hide members
11.1TICAM1, TLR3, CREB3, TRAF3
5
Hide members
11.1TICAM1, TLR3, UNC93B1, TRAF3
611.1TICAM1, TLR3, TRAF3, EIF2AK2
7
Hide members
10.9TRAF3, TLR3, TICAM1
8
Hide members
10.9TRAF3, TLR3, TICAM1
910.9TICAM1, TLR3, TRAF3
1010.8UNC93B1, TLR3
1110.8PVRL2, PVRL1
1210.8PVRL2, PVRL1

Compounds for genes affiliated with Herpes Simplex

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44Novoseek, 59Tocris Bioscience
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Compounds related to Herpes Simplex according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine4411.7PVRL1, PVRL2, TLR3, TRAF3, DARC, EIF2AK2
2poly(i-c)4411.0EIF2AK2, TLR3, TICAM1
3poly c4410.8EIF2AK2, TLR3
4rantes4410.7DARC, EIF2AK2
5tunicamycin44 5911.6EIF2AK2, CREB3, PPP1R15A

GO Terms for genes affiliated with Herpes Simplex

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16Gene Ontology
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Biological processes related to Herpes Simplex according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904811.7EIF2AK2, HCFC1, CREB3, TNFRSF14, PVRL2, PVRL1
2toll-like receptor 3 signaling pathwayGO:03413811.4TICAM1, TLR3, UNC93B1, TRAF3
3toll-like receptor signaling pathwayGO:00222411.4TICAM1, TLR3, UNC93B1, TRAF3
4defense response to virusGO:05160711.3TICAM1, TLR3, UNC93B1, EIF2AK2
5innate immune responseGO:04508711.2EIF2AK2, TRAF3, UNC93B1, TLR3, TICAM1
6positive regulation of interleukin-6 productionGO:03275511.2IL36G, TLR3, TICAM1
7inflammatory responseGO:00695411.2TICAM1, TLR3, IL36G, DARC
8TRIF-dependent toll-like receptor signaling pathwayGO:03566611.1TRAF3, TLR3, TICAM1
9MyD88-independent toll-like receptor signaling pathwayGO:00275611.1TICAM1, TLR3, TRAF3
10release from viral latencyGO:01904611.1HCFC1, CREB3
11toll-like receptor 4 signaling pathwayGO:03414211.1TRAF3, TLR3, TICAM1
12positive regulation of interferon-beta biosynthetic processGO:04535911.0TLR3, TICAM1
13positive regulation of chemokine biosynthetic processGO:04508011.0TICAM1, TLR3
14positive regulation of NF-kappaB transcription factor activityGO:05109210.8TICAM1, TLR3, EIF2AK2
15response to exogenous dsRNAGO:04333010.8TLR3, TICAM1
16positive regulation of chemokine productionGO:03272210.5EIF2AK2, TLR3

Molecular functions related to Herpes Simplex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coreceptor activityGO:01502610.8PVRL2, PVRL1
2virus receptor activityGO:00161810.6TNFRSF14, PVRL2, PVRL1

Products for genes affiliated with Herpes Simplex

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Herpes Simplex

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet