MCID: HRP006
MIFTS: 63

Herpes Simplex malady

Summaries for Herpes Simplex

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Herpes is an infection that is caused by a herpes simplex virus (hsv). oral herpes causes cold sores around the mouth or face. genital herpes affects the genitals, buttocks or anal area. genital herpes is a sexually transmitted disease (std). it affects the genitals, buttocks or anal area. other herpes infections can affect the eyes, skin, or other parts of the body. the virus can be dangerous in newborn babies or in people with weak immune systems. there are two types of hsv: hsv type 1 most commonly causes cold sores. it can also cause genital herpes. hsv type 2 is the usual cause of genital herpes, but it also can infect the mouth. hsv spreads through direct contact. some people have no symptoms. others get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. most people have outbreaks several times a year. over time, you get them less often. medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards: Herpes Simplex, also known as herpesvirus hominis disease, is related to encephalitis and hepatitis. An important gene associated with Herpes Simplex is TNFRSF14 (tumor necrosis factor receptor superfamily, member 14), and among its related pathways are Influenza A and Immune System. The drugs benzocaine and methylene blue and the compounds tyrosine and poly(i-c) have been mentioned in the context of this disorder. Affiliated tissues include genitalia, face and h.

Disease Ontology:8 A viral infectious disease that results in formation of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia:63 Herpes simplex (Greek: ἕρπης herpēs, \"creeping\" or \"latent\") is a viral disease from the... more...

Aliases & Classifications for Herpes Simplex

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

herpes simplex 8 10 44 33
herpesvirus hominis disease 8
herpes simplex infections 60


External Ids:

Disease Ontology8 DOID:8566
MeSH34 D006561
ICD9CM27 054

Related Diseases for Herpes Simplex

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Herpes Simplex:



Diseases related to herpes simplex

Clinical Features for Herpes Simplex

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Drugs & Therapeutics for Herpes Simplex

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Herpes Simplex

Drug clinical trials:

Search ClinicalTrials for Herpes Simplex

Search NIH Clinical Center for Herpes Simplex

Search CenterWatch for Herpes Simplex

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Herpes Simplex

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Anatomical Context for Herpes Simplex

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Herpes Simplex:

32
Skin, T cells, Eye, Brain, Testes, Liver, Endothelial, Lung, Breast, Monocytes, B cells, Prostate, Bone, Temporal lobe, Colon, Thyroid, Bone marrow, Nk cells, Trigeminal ganglion, Cortex, Tongue, Myeloid, Heart, Dorsal root ganglion, Whole blood, Thalamus, Thymus, Tonsil, Cervix, Ovary, Placenta, Pancreas, Pituitary, Spinal cord, Kidney, Lymph node

FMA organs/tissues related to Herpes Simplex:

14
Genitalia, Face, H, Mouth

Animal Models for Herpes Simplex or affiliated genes

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Publications for Herpes Simplex

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50PubMed
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Articles related to Herpes Simplex:

(show top 50)    (show all 2652)
idTitleAuthorsYear
1
An in silico approach to design potential siRNA molecules for ICP22 (US1) gene silencing of different strains of human herpes simplex 1. (24023453)
2013
2
MicroRNA-145 regulates oncolytic herpes simplex virus-1 for selective killing of human non-small cell lung cancer cells. (23876001)
2013
3
mRNA decay during herpes simplex virus (HSV) infections: mutations that affect translation of an mRNA influence the sites at which it is cleaved by the HSV virion host shutoff (Vhs) protein. (23077305)
2013
4
Atypical Presentation of Genital Herpes Simplex (HSV-2) in Two Patients with Chronic Lymphocytic Leukemia. (23975187)
2013
5
Intracerebral propagation of Alzheimer's disease: strengthening evidence of a herpes simplex virus etiology. (23159044)
2013
6
Disseminated cutaneous herpes simplex infection in a patient with Crohn's disease under azathioprine and steroids: First case report and literature review. (24257435)
2013
7
Herpes simplex virus antigens directly activate NK cells via TLR2, thus facilitating their presentation to CD4 T lymphocytes. (22467654)
2012
8
Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice. (22647700)
2012
9
Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo. (21632763)
2011
10
Common variable immunodeficiency presenting as herpes simplex virus encephalitis. (21167568)
2011
11
Malingering or expected deficits? A case of herpes simplex encephalitis. (20401805)
2010
12
Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions. (19835589)
2009
13
MRI deterioration in herpes simplex encephalitis despite clinical recovery. (19590384)
2009
14
A delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology. (17989585)
2008
15
Small interfering RNAs that deplete the cellular translation factor eIF4H impede mRNA degradation by the virion host shutoff protein of herpes simplex virus. (18448541)
2008
16
Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy. (18091066)
2007
17
Outcome of herpes simplex encephalitis in children. (17332904)
2007
18
Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction. (17126870)
2007
19
Maternal herpes simplex virus antibody avidity and risk of neonatal herpes. (16813750)
2006
20
Herpes simplex encephalitis presenting with bilateral hippocampal lesions on magnetic resonance imaging, simultaneously complicated by small cell lung carcinoma. (16258223)
2005
21
Epidemiology of genital herpes simplex virus infections in a community-based sample in France: results of the HERPIMAX study. (16041253)
2005
22
Herpes simplex virus keratitis after laser in situ keratomileusis. (16128340)
2005
23
Transient urinary retention and chronic neuropathic pain associated with genital herpes simplex virus infection. (15453891)
2004
24
Immunization strategies to block the herpes simplex virus type 1 immunoglobulin G Fc receptor. (14963159)
2004
25
Predominance of herpes simplex virus type 1 from patients with genital herpes in Nova Scotia. (18159431)
2003
26
Herpes simplex viral pneumonia after coronary artery bypass grafting. (12723587)
2003
27
Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell leukemia virus type I Tax protein. (11747607)
2001
28
Co-transduction of herpes simplex virus thymidine kinase gene and human interleukin-2 gene into mouse ovarian cancer cell line, OVHM. (10891564)
2000
29
Tumour-killing herpes simplex virus - a promising new approach for brain cancer. (10498918)
1999
30
The comparative anti-herpes simplex virus effects of human interferons. (9555977)
1998
31
Herpes simplex virus gD and virions accumulate in endosomes by mannose 6-phosphate-dependent and -independent mechanisms. (9525660)
1998
32
Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer. (9796978)
1998
33
Mixed vaginal infections of Balb/c mice with low virulent herpes simplex type 1 strains result in restoration of virulence properties: vaginitis/vulvitis and neuroinvasiveness. (9138293)
1997
34
The protein kinase activity of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) fused to the extracellular domain of the epidermal growth factor receptor is ligand-inducible. (8610433)
1996
35
Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. (8700844)
1996
36
Herpes simplex viral pneumonia in the postthoracotomy patient. (7656651)
1995
37
Role of acyclovir in the treatment of herpes simplex virus keratitis. (7960531)
1994
38
Murine herpes simplex virus keratitis is accentuated by CD4+, V beta 8.2+ Th2 T cells. (7908153)
1993
39
Herpes simplex virus infection. A rare cause of prolonged croup. (8387316)
1993
40
Brief report: autism and herpes simplex encephalitis. (1592760)
1992
41
ERPs and brain structure: relationships across the adult age span in alcoholics and in a patient with herpes simplex encephalitis. (1915027)
1991
42
Herpes simplex virus glycoprotein D. Protective immunity against murine herpetic keratitis. (2318582)
1990
43
The effect of flurbiprofen on herpes simplex virus type 1 stromal keratitis in mice. (2167299)
1990
44
Empiric therapy with acyclovir for suspected neonatal herpes simplex infection. (2594463)
1989
45
Early diagnosis of herpes simplex encephalitis by MRI. (3808297)
1987
46
Experimental herpes simplex encephalitis in rats after intranasal inoculation. An immunohistologic study. (6715202)
1984
47
Disseminated neonatal herpes simplex virus type 1 from a maternal breast lesion. (6828354)
1983
48
The development of retinitis in mice with nonfatal herpes simplex encephalitis. (7133314)
1982
49
Postexposure serum prophylaxis of neonatal herpes simplex virus infection of mice. (180414)
1976
50
Antiviral chemotherapy and neonatal herpes simplex virus infecition: a pilot study--experience with adenine arabinoside (ARA-A). (165453)
1975

Genetic Variations for Herpes Simplex

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Expression for genes affiliated with Herpes Simplex

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Herpes Simplex

Search GEO for disease gene expression data for Herpes Simplex.

Pathways for genes affiliated with Herpes Simplex

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29KEGG, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 4Cell Signaling Technology
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Pathways related to Herpes Simplex according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9EIF2AK2, PVRL1, PVRL2, TICAM1, TLR3, TNFRSF14
2
Hide members
11.6PVRL2, TICAM1, TLR3, TNFRSF14, UNC93B1, TRAF3
3
Hide members
11.1TLR3, TNFRSF14, CREB3, TRAF3
4
Hide members
11.1TICAM1, TLR3, CREB3, TRAF3
5
Hide members
11.1TICAM1, TLR3, UNC93B1, TRAF3
611.1TICAM1, TLR3, TRAF3, EIF2AK2
7
Hide members
10.9TRAF3, TLR3, TICAM1
8
Hide members
10.9TRAF3, TLR3, TICAM1
910.9TICAM1, TLR3, TRAF3
1010.8UNC93B1, TLR3
1110.8PVRL2, PVRL1
1210.8PVRL2, PVRL1

Compounds for genes affiliated with Herpes Simplex

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44Novoseek, 59Tocris Bioscience
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Compounds related to Herpes Simplex according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine4411.7PVRL1, PVRL2, TLR3, TRAF3, DARC, EIF2AK2
2poly(i-c)4411.0EIF2AK2, TLR3, TICAM1
3poly c4410.8EIF2AK2, TLR3
4rantes4410.7DARC, EIF2AK2
5tunicamycin44 5911.6EIF2AK2, CREB3, PPP1R15A

GO Terms for genes affiliated with Herpes Simplex

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16Gene Ontology
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Biological processes related to Herpes Simplex according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904811.7HCFC1, CREB3, TNFRSF14, PVRL2, PVRL1, EIF2AK2
2toll-like receptor 3 signaling pathwayGO:03413811.4TLR3, TRAF3, UNC93B1, TICAM1
3toll-like receptor signaling pathwayGO:00222411.4TRAF3, UNC93B1, TLR3, TICAM1
4defense response to virusGO:05160711.3TLR3, UNC93B1, EIF2AK2, TICAM1
5innate immune responseGO:04508711.2TRAF3, TICAM1, TLR3, UNC93B1, EIF2AK2
6positive regulation of interleukin-6 productionGO:03275511.2TICAM1, TLR3, IL36G
7inflammatory responseGO:00695411.2TLR3, TICAM1, IL36G, DARC
8TRIF-dependent toll-like receptor signaling pathwayGO:03566611.1TICAM1, TRAF3, TLR3
9MyD88-independent toll-like receptor signaling pathwayGO:00275611.1TRAF3, TLR3, TICAM1
10release from viral latencyGO:01904611.1HCFC1, CREB3
11toll-like receptor 4 signaling pathwayGO:03414211.1TLR3, TICAM1, TRAF3
12positive regulation of interferon-beta biosynthetic processGO:04535911.0TICAM1, TLR3
13positive regulation of chemokine biosynthetic processGO:04508011.0TLR3, TICAM1
14positive regulation of NF-kappaB transcription factor activityGO:05109210.8TICAM1, TLR3, EIF2AK2
15response to exogenous dsRNAGO:04333010.8TICAM1, TLR3
16positive regulation of chemokine productionGO:03272210.5EIF2AK2, TLR3

Molecular functions related to Herpes Simplex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coreceptor activityGO:01502610.8PVRL2, PVRL1
2virus receptor activityGO:00161810.6TNFRSF14, PVRL2, PVRL1

Products for genes affiliated with Herpes Simplex

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Herpes Simplex

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet