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MCID: HRP006

Herpes Simplex malady
3 drugs, 486 genes, 24 tissues, 853 related diseases, 29 phenotypes, 789 articles, clinical trials.

Summaries for Herpes Simplex

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6Disease Ontology, 23MedlinePlus, 44Wikipedia, 22MalaCards
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MedlinePlus: Herpes is an infection that is caused by a herpes simplex virus (hsv). oral herpes causes cold sores around the mouth or face. genital herpes affects the genitals, buttocks or anal area. genital herpes is a sexually transmitted disease (std). it affects the genitals, buttocks or anal area. other herpes infections can affect the eyes, skin, or other parts of the body. the virus can be dangerous in newborn babies or in people with weak immune systems. there are two types of hsv: hsv type 1 most commonly causes cold sores. it can also cause genital herpes. hsv type 2 is the usual cause of genital herpes, but it also can infect the mouth. hsv spreads direct contact. some people have no symptoms. others get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. most people have outbreaks several times a year. over time, you get them less often. medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.23

MalaCards: Herpes Simplex, also known as herpesvirus hominis disease, is related to carcinoma and leukemia. An important gene associated with Herpes Simplex is TNFRSF14 (tumor necrosis factor receptor superfamily, member 14), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Akt Signaling. The drugs methylene blue and benzocaine pwdr [va product] and the compounds calcium and atp have been mentioned in the context of this disorder. Affiliated tissues include mouth, face and genitalia, and related mouse phenotypes are mortality/aging and hematopoietic system.

Disease Ontology: A viral infectious disease that results in formation of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.6

Wikipedia: Herpes simplex (Greek: ἕρπης herpēs, \"creeping\" or \"latent\") is a viral disease from the...44 more...

Aliases & Descriptions for Herpes Simplex

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6Disease Ontology, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS, 40SNOMED-CT, 19ICD9CM, 24MeSH
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Aliases & Descriptions:

herpes simplex 6 8 32 23
herpesvirus hominis disease 6
herpes simplex infections 43

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ICD9CM19 054
SNOMED-CT40 266191005, 88594005, 154332007 186534002, more

Related Diseases for Herpes Simplex

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13GeneCards, 14GeneDecks
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Diseases related to herpes simplex by text searches and GeneDecks gene sharing:

(show top 50)    (show all 850)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma55.4PIK3CA, PIK3CG, KLHDC2, NCL, RECK, REST
2leukemia47.7PIAS2, PIK3CA, PICALM, PIK3CG, NCL, NCR1
3neuronitis47.4PIK3CA, PICALM, PIK3CG, NCL, PDCD6IP, RECK
4prostatitis42.6PIAS2, PIK3CA, PIK3CG, NCL, RECK, KIF5B
5melanoma39.8PIK3CA, PIK3CG, NCL, RECK, PCNA, SERPINE1
6hepatocellular carcinoma39.2PIK3CA, PIK3CG, KLHDC2, NCL, RECK, PCNA
7immunodeficiency39.2MYD88, ZFP36, PARK2, LGALS1, LCK, CFLAR
8arthritis38.9PILRA, PIK3CG, RECK, CNTN2, PCNA, GC
9pancreatitis38.8PIK3CA, PIK3CG, NCL, RECK, REST, KIAA0664
10thyroiditis38.1PIK3CA, PICALM, PIK3CG, RECK, PCNA, GC
11influenza37.4PIK3CA, PIK3CG, NCL, NCR1, NCR2, RECK
12genital herpes37.2T, IL4, APOE, CCL3, CCL5, IFNA1
13herpes simplex encephalitis36.7UNC93B1, S100B, IL2RB, APOE, ELANE, TLR3
14cervicitis35.8PIK3CA, PIK3CG, NCL, NCR1, NCR2, RECK
15sarcoma35.4PIK3CA, PIK3CG, RECK, PCNA, GC, SERPINC1
16encephalitis35.3PIK3CG, VEGFA, MYD88, RAF1, BDNF, BCL2
17colon cancer35.0PIAS2, PIK3CA, PIK3CG, RECK, PCNA, GC
18hepatitis34.5IL2RB, FASLG, FAS, GPT, IFNA1, IFNA2
19ovarian cancer34.3PIK3CA, PIK3CG, RECK, REST, PCNA, SERPINC1
20keratitis34.1VEGFA, MYD88, T, JUN, MIF, FGF2
21herpetic keratitis33.9IL6, IFNA1, HLA-DRA, DARC, NGF, TLR9
22candidiasis33.9CD86, CD40LG, CD83, MIF, IL10, IL13
23lung carcinoma33.4PIK3CA, PIK3CG, RECK, PCNA, VEGFA, LMNA
24retinitis33.0PIK3CA, PIK3CG, RCC1, PCNA, SERPINC1, SERPINE1
25wiskott-aldrich syndrome32.9PIK3CG, NCL, RECK, RAC1, LCK, CFP
26encephalomyelitis32.8VEGFA, BDNF, LGALS3, S100B, CFLAR, CD86
27atopic dermatitis32.5BDNF, LGALS3, LBR, CD86, CD83, MIF
28herpes zoster32.2GYPC, IL10, IL4, APOE, CCR5, IFNA1
29cerebritis32.2PIK3CG, REST, CNTN2, PCNA, GC, SERPINC1
30squamous cell carcinoma32.2PIK3CA, NCL, RECK, PCNA, GC, VIM
31schizophrenia32.0MICB, IL10RA, IL1B, IL1RN, IL2, IL3
32alzheimer's disease31.9PIK3CA, PICALM, PIK3CG, NCL, NCR2, RECK
33dermatitis31.9NCR1, NCR2, VIM, VEGFA, CLDN1, BGLAP
34ischemia31.9PIK3CA, PIK3CG, PCNA, GC, SELPLG, SERPINC1
35neurologic diseases31.8RECK, CNTN2, MYO5A, ATP1A2, CD80, ITIH4
36cholesterol31.8PIK3CA, PIK3CG, PDCD6IP, RECK, GC, SELPLG
37erythema multiforme31.6FAS, CCL2, CCL5, ICAM1, F3, TNF
38pneumonia31.5SERPINC1, SERPINE1, VIM, VEGFA, LPO, MYD88
39ataxia31.5PIK3CA, PIK3CG, PCNA, SERPINE1, VIM, MYC
40xeroderma pigmentosum31.5PCNA, LMNA, LIG4, BCL2, UNG, UBC
41neuroblastoma31.5PIAS2, PIK3CA, PIK3CG, NCL, RECK, REST
42viral hepatitis31.5PCNA, SERPINC1, BGLAP, MX1, BAX, CFLAR
43t-cell leukemia31.5PIK3CG, CNTN2, MYC, RAG2, RAG1, RAF1
44gastric cancer31.2PIK3CA, PIK3CG, NCL, RECK, PCNA, SERPINE1
45vaginitis31.1GC, SERPINC1, SERPINE1, VIM, BGLAP, BCL2
46rabies31.1GC, VIM, VEGFA, RAB1A, RAB1B, BCL2
47juvenile rheumatoid arthritis30.9BGLAP, LBR, IL1R1, IL1RAPL2, IL1RN, IL2RA
48kaposi's sarcoma30.6VEGFA, LBR, CFLAR, FGF2, FGFR2, IL6
49eczema30.6LGALS3, LBR, CD40LG, CD1D, IL10, IL10RA
50multiple sclerosis30.5CD226, MICB, MICA, IL1B, IL1RN, IL2RA

Graphical network of the top 20 diseases related to herpes simplex:



Graphical network of diseases related to herpes simplex

Clinical Features for Herpes Simplex

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Drugs & Therapeutics for Herpes Simplex

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for herpes simplex

Inferred drug relations via UMLS/NDF-RT:

43 28 benzocaine, benzocaine pwdr [va product], methylene blue

Genetic Tests for Herpes Simplex

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Anatomical Context for Herpes Simplex

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11FMA, 22MalaCards
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MalaCards organs/tissues related to herpes simplex:

22
Bone marrow, Thymus, Brain, Cortex, Colon, Liver, Lung, Thyroid, Skin, Ovary, Placenta, Prostate, Myeloid, Monocytes, T cells, B cells, Endothelial, Dorsal root ganglion, Trigeminal ganglion, Tongue

FMA organs/tissues related to herpes simplex:

11
Mouth, Face, Genitalia, H

Phenotypes for genes affiliated with Herpes Simplex

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25MGI
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MGI Mouse Phenotypes related to herpes simplex:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1mortality/agingMP:001076817.6PIK3CA, PICALM, NCR1, RECK, REST, KIF5B
2hematopoietic system phenotypeMP:000539716.2PICALM, NCR1, PCNA, SENP1, MYD88, RAG2
3behavior/neurological phenotypeMP:000538615.7PIK3CA, CNTN2, KIF1A, SENP1, VIM, LMNA
4cellular phenotypeMP:000538415.7PIK3CA, PICALM, PIK3CG, REST, KIF5B, KIF22
5normal phenotypeMP:000287314.0PIAS2, NCR1, VEGFA, LMNA, MYC, MYO5A
6respiratory system phenotypeMP:000538813.1RAG2, RAG1, BID, PARK2, BDNF, SCG5
7liver/biliary system phenotypeMP:000537012.3PICALM, RECK, SERPINC1, SENP1, VEGFA, RAG2
8craniofacial phenotypeMP:000538212.1LMNB1, MYO5A, RAG2, LIG4, LIG3, BDNF
9renal/urinary system phenotypeMP:000536712.1SELPLG, LMNA, MYD88, RAG1, CLU, ZFP36
10embryogenesis phenotypeMP:000538012.0PIK3CA, PICALM, RECK, REST, KIF5B, KIF22
11no phenotypic analysisMP:000301211.7REST, KIF22, PCNA, SENP1, VEGFA, MYC
12digestive/alimentary phenotypeMP:000538111.3VEGFA, LMNA, MYC, RAG2, RAG1, LIG4
13reproductive system phenotypeMP:000538911.1PIK3CA, VEGFA, LMNA, RAG2, LIG4, CLOCK
14hearing/vestibular/ear phenotypeMP:000537710.8LMNA, MYC, MYD88, MYO5A, RAG1, BDNF
15skeleton phenotypeMP:000539010.7PIK3CG, RECK, GC, VEGFA, LMNA, MYC
16other phenotypeMP:000539510.6RECK, CLU, CDKN2A, CD40LG, IL13, IL2
17limbs/digits/tail phenotypeMP:000537110.5RECK, VEGFA, LMNA, MYO5A, RAC1, BAX
18tumorigenesisMP:000200610.4PIK3CA, SERPINE1, MYC, MYD88, RAG2, RAG1
19adipose tissue phenotypeMP:00053759.9PIK3CA, SERPINE1, LMNA, MYC, MYD88, CLOCK
20vision/eye phenotypeMP:00053919.8PIK3CA, REST, SERPINC1, VIM, VEGFA, LMNA
21pigmentation phenotypeMP:00011869.3SERPINC1, LMNA, MYC, MYO5A, RAG1, RAC1
22muscle phenotypeMP:0005369INFPIK3CA, PIK3CG, VIM, VEGFA, LMNA, LMNB1
23growth/size phenotypeMP:0005378INFPIK3CA, PICALM, PIK3CG, RECK, REST, KIF5B
24nervous system phenotypeMP:0003631INFRECK, REST, CNTN2, SERPINC1, LMNA, LMNB1
25homeostasis/metabolism phenotypeMP:0005376INFPIK3CA, PICALM, PIK3CG, KIF5B, GC, SELPLG
26integument phenotypeMP:0010771INFPIK3CG, RECK, KIF1A, SELPLG, SENP1, LMNB1
27immune system phenotypeMP:0005387INFPICALM, SELPLG, SENP1, VIM, LMNA, MYD88
28endocrine/exocrine gland phenotypeMP:0005379INFKIF5B, PAIP2, SCG5, FUT1, CDC42, CD40LG
29cardiovascular system phenotypeMP:0005385INFPIK3CA, PIK3CG, RECK, SERPINC1, SENP1, SERPINE1

Publications for genes affiliated with Herpes Simplex

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35PubMed
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Articles related to herpes simplex:

(show top 50)    (show all 789)
idTitleAuthorsYearAffiliating Genes
1Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affectin g disease risk. (21919190)Demontis D.... Mortensen P.B.2011GRIN2B
2The herpes simplex virus-1 transactivator infected ce ll protein-4 drives VEGF-A dependent neovascularization. (21998580)Wuest T.... Carr D.J.2011VEGFA
3NEMO is a key component of NF-I_B- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus. (21722947)Audry M.... Puel A.2011TLR3, IKBKG
4Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis. (21489616)De Benedetto A.... Beck L.A.2011CLDN1
5Herpes simplex virus UL56 interacts with and regulate s the Nedd4-family ubiquitin ligase Itch. (20682038)Ushijima Y.... Nishiyama Y.2010ITCH
6Herpes simplex virus type 1 dysregulates anti-fungal defenses preventing monocyte activation and downregulating toll-like receptor-2. (19120971)Cermelli C.... Blasi E.2008TLR2
7Small interfering RNAs that deplete the cellular translation factor eIF4H impede mRNA degradation by the virion host shutoff protein of herpes simplex virus. (18448541)Sarma N.... Read G.S.2008EIF4H
8Uracil-DNA glycosylase (UNG) influences the melting temperature (T(m)) of herpes simplex virus (HSV) hybridization probes. (18468698)LeBlanc J.J.... Hatchette T.F.2008UNG
9Susceptibility to herpes simplex labialis conferred by the gene encoding apolipoprotein E. (18652551)Itzhaki R.... Wozniak M.2008APOE
10Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and Ganglia. (17459924)Wang K.... Straus S.E.2007TKT
11The cysteine protease inhibitors cystatins inhibit herpes simplex virus type 1-induced apoptosis and virus yield in HEp-2 cells. (17622610)Peri P.... Vuorinen T.2007CSTA, CST5
12Complexes between herpes simplex virus glycoproteins gD, gB, and gH detected in cells by complementation of split enhanced green fluorescent protein. (17670828)Avitabile E.... Campadelli-Fiume G.2007GGH
13Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes. (16501095)Koelle D.M.... McClurkan C.L.2006SELPLG
14Expression of entry receptor nectin-1 of herpes simplex virus 1 and/or herpes simplex virus 2 in normal and neoplastic human nervous system tissues. (16599187)Guzman G.... Valyi-Nagy T.2006PVRL1
15PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0. (16873256)Everett R.D.... Orr A.2006PML
16Herpes simplex virus infection stabilizes cellular IEX-1 mRNA. (15767410)Hsu W.L.... Smiley J.R.2005IER3
17Herpes simplex virus thymidine kinase mutations associated with resistance to acyclovir: a site-directed mutagenesis study. (15728902)Frobert E.... Morfin F.2005TKT
18Direct evidence for the absence of intercellular trafficking of VP22 fused to GFP or to the herpes simplex virus thymidine kinase. (15483667)Roy V.... Caruso M.2005TKT
19Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator. (15016549)Ono E.... Uede T.2004DARC
20Herpes simplex virus type-1-induced activation of mye loid dendritic cells: the roles of virus cell interaction and paracrine type I IFN secretion. (15356161)Pollara G.... Katz D.R.2004UBASH3B
21Nuclear sequestration of cellular chaperone and proteasomal machinery during herpes simplex virus type 1 infection. (15194794)Burch A.D.... Weller S.K.2004HSPA8, DNAJB1
22The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes. (14747533)Lin R.... Mossman K.L.2004IRF3, IRF7
23A case of acute liver failure caused by herpes simplex type 2. (15307595)Boysen T.... Clausen M.R.2004MBL2
24Herpes simplex virus type 1-encoded glycoprotein C enhances coagulation factor VIIa activity on the virus. (15543320)Sutherland M.R.... Pryzdial E.L.2004F7
25Reconstitution of recombination-dependent DNA synthesis in herpes simplex virus 1. (12928502)Nimonkar A.V.... Boehmer P.E.2003ENDOG
26Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence. (11773369)Cassady K.A.... Roizman B.2002EIF2S1, EIF2AK2, TTF2
27ICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathway. (12438613)Chen I.-H.B.... Sandri-Goldin R.M.2002ALYREF
28Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0. (11053442)Lomonte P.... Everett R.D.2001CENPA
29Herpes simplex virus glycoprotein D bound to the human receptor HveA. (11511370)Carfi A.... Wiley D.C.2001TNFRSF14
30Different patterns of induction of fibroblast growth factor-2 and brain-derived neurotrophic factor messenger RNAs during kindling e pileptogenesis, and development of a herpes simplex vector for fibroblast growt h factor-2 gene transfer in vivo. (10999533)Bregola G.... Simonato M.2000BDNF
31Enzyme prodrug gene therapy: synergistic use of the herpes simplex virus-cellular thymidine kinase/ganciclovir system and thymidylate synthase inhibitors for the treatment of colon cancer. (10537302)Wildner O.... Candotti F.1999TYMS
32Nucleotide sequence of thymidine kinase gene of seque ntial acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: evidence for reactivation of acyclovir-re sistant herpes simplex virus. (10421406)Saijo M.... Morikawa S.1999TKT
33BCL-2 transduction, using a herpes simplex virus ampl icon, protects hippocampal neurons from transient global ischemia. (10192784)Antonawich F.J.... Davis J.N.1999BAX
34An important role for major histocompatibility complex class I-restricted T cells, and a limited role for gamma interferon, in protection of mice against lethal herpes simplex virus infection. (9971787)Holterman A.X.... Wilson C.B.1999IFNG
35Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription. (9621021)Schang L.M.... Schaffer P.A.1998MAPK3
36A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus. (9657005)Warner M.S.... Spear P.G.1998TNFRSF14, PVRL2
37In vivo production of cytokines and beta (C-C) chemokines in human recurrent herpes simplex lesions--do herpes simplex virus-infected keratinocytes contribute to their production? (9534953)Mikloska Z.... Cunningham A.L.1998IL6, IL1B, IFNG
38Enhanced tumor cell killing in the presence of ganciclovir by herpes simplex virus type 1 vector-directed coexpression of human tumor necrosis factor-alpha and herpes simplex virus thymidine kinase. (9865731)Moriuchi S.... Glorioso J.C.1998TKT
39Interaction of herpes simplex virus 1 alpha regulatory protein ICP0 with elongation factor 1delta: ICP0 affects translational machinery. (8995621)Kawaguchi Y.... Roizman B.1997EEF1D
40Inhibition of herpes simplex virus type 1 immediate-early gene expression by alpha interferon is not VP16 specific. (8709261)Nicholl M.J.... Preston C.M.1996IFNA1
41Improved adenovirus vector provides herpes simplex virus ribonucleotide reductase R1 and R2 subunits very efficiently. (9634800)Massie B.... Langelier Y.1995RRM1
42The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides. (7876203)Kristie T.M.... Sharp P.A.1995HCFC1
43Requirements for activation of the herpes simplex virus glycoprotein C promoter in vitro by the viral regulatory protein ICP4. (7966586)Gu B.... DeLuca N.1994GBA
44Herpes simplex virus 1 gamma(1)34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage. (8202476)Chou J.... Roizman B.1994PPP1R15A
45Immunological investigation of adult patients with pr imary herpes simplex virus-1 infection. (8102649)Yamamoto T.... Ueta E.1993IFNG
46Heparan sulfate glycosaminoglycans as primary cell su rface receptors for herpes simplex virus. (1332443)Spear P.G.... Koshy T.I.1992AZU1
47Cooperative interactions between replication origin-bound molecules of herpes simplex virus origin-binding protein are mediated via the amino terminus of the protein. (1321142)Hazuda D.J.... McClements W.L.1992KIF22
48Differential suppression of host cell protein synthesis and mRNA levels in herpes simplex virus-infected endothelial cells. (1891960)Brinker J.M.... Kefalides N.A.1991THBS1, ADAMTSL1
49Computer-aided active-site-directed modeling of the herpes simplex virus 1 and human thymidine kinase. (1663155)Folkers G.... Keil G.M.1991DTYMK, EEF1A1, TKT
50Expression of herpes simplex virus type 1 glycoproteins in interferon-treated human neuroblastoma cells. (2168998)Chatterjee S.... Burns P.1990IFNA1

Expression for genes affiliated with Herpes Simplex

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Herpes Simplex

Pathways for genes affiliated with Herpes Simplex

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36QIAGEN, 20KEGG, 41Thomson Reuters, 10EMD Millipore, 37R&D Systems
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Pathways related to herpes simplex according to GeneDecks:

(show top 50)    (show all 357)
idPathwayScoreTop Affiliating Genes
1RAR-Gamma-RXR-Alpha Degradation3611.9UBC, CDK7, CD80, GTF2A1, GTF2B, IL15
2Akt Signaling3611.5PIK3CG, RAF1, CD80, ITGAL, IRS1, IL10
3Cytosolic DNA-sensing pathway2011.3IRF3, IRF7, IL18, IL1B, IL6, CCL4
4Bacterial infections in CF airways4111.2MYD88, IRF1, IL1R1, IKBKB, IKBKG, CTSS
5Apoptosis and survival Role of CDK5 in neuronal death and survival1010.9BCL2, CDK5, CASP9, CYCS, NGF
6IL-6 Pathway3610.8RAF1, BAX, CD80, GRB2, IL10, IL18
7NF-KappaB Family Pathway3610.8MYD88, BDNF, FGF2, FGFR2, IL1B, IL1R1
8Tec Kinases Signaling3610.8MYD88, RAC1, BDNF, BCL2, BAX, CDC42
9Measles2010.8PIK3CA, PIK3CG, MYD88, MX1, MSN, CD209
10Toll-Like Receptor Signaling Pathways3710.7MYD88, JUN, IRF3, IRF7, IL18, IL1B
11Colorectal cancer2010.7PIK3CG, RAC1, MAPK8, MAP2K1, CASP9, TGFB2
12Influenza A2010.6PIK3CA, PIK3CG, MYD88, RAF1, MX1, XPO1
13PGC1Alpha Pathway3610.6BCL2, BAX, CD80, IL10RA, IL13, IL15
14SOCS Pathway3610.5BCL2, BAX, CD80, IRS1, FGF2, IL10
15Rho Family GTPases3610.3VIM, RAF1, RAC1, BDNF, BCL2, BAX
16TREM1 Pathway3610.2MYD88, RAF1, BID, BAX, JUN, GRB2
17p38 Signaling3610.2RAC1, BDNF, BCL2, LCK, BAX, CDC42
18JNK Pathway3610.1RAF1, RAC1, BCL2, BAX, JUN, CDC42
19MIF Mediated Glucocorticoid Regulation3610.1BCL2, BAX, CD80, MIF, IL10, IL13
20Cytokine-cytokine receptor interaction2010.0VEGFA, CD40LG, FLT3LG, IL10, IL10RA, IL13
21Glucocorticoid Receptor Signaling3610.0BCL2, BAX, JUN, CD80, GTF2A1, GTF2B
22Neurotrophin signaling pathway2010.0PIK3CA, PIK3CG, RAF1, RAC1, BDNF, BAX
23Osteoclast differentiation209.9PIK3CA, PIK3CG, RAC1, LILRB2, LCK, JUN
24STAT3 Pathway369.9MYC, RAF1, RAC1, BCL2, BAX, CD80
25MIF Regulation of Innate Immune Cells369.8BCL2, BAX, JUN, CD80, MIF, IL10
26TGF-Beta Pathway369.8BDNF, BCL2, BAX, JUN, CD80, FGF2
27Cytokine Network369.8IL10, IL13, IL15, IL18, IL1B, IL2
28JAK-STAT Pathway369.8MYC, RAF1, BDNF, BCL2, UBC, BAX
29HMGB1 Pathway369.6RAC1, JUN, CDC42, IL1B, IL1R1, MAPK8
30Immune response_IL-1 signaling pathway419.6SERPINE1, MYD88, UBC, JUN, IRF1, IL1B
31SUMO Pathway369.6RANGAP1, IL1B, IL1R1, MAPK8, MAP2K2, MAPK14
32Estrogen Pathway369.3RAF1, BDNF, BCL2, JUN, GTF2A1, GTF2B
33Hepatitis C209.3PIAS2, PIK3CA, PIK3CG, RAF1, CLDN1, IRF1
34Apoptosis and survival_Role of CDK5 in neuronal death and survival419.3PIK3CA, RAF1, BCL2, BAX, JUN, CDK5
35T cell receptor signaling pathway209.3PIK3CA, PIK3CG, RAF1, LCK, JUN, CDC42
36Immune response_MIF-mediated glucocorticoid regulation419.2JUN, MIF, IL2, IL6, IL8, MAPK3
37Rheumatoid arthritis209.0VEGFA, JUN, CD86, CD80, ITGAL, IL15
38Colorectal Cancer Metastasis369.0MYC, BAX, GRB2, IL6, APC, MAP2K2
39Prostate cancer208.9PIK3CA, PIK3CG, RAF1, BCL2, CDK2, FGFR2
40Development Prolactin receptor signaling108.8PIK3CA, MYC, RAF1, RAC1, BCL2, JUN
41Development_Prolactin receptor signaling418.7PIK3CA, MYC, RAF1, RAC1, BCL2, JUN
42PAK Pathway36INFMYO5A, RAC1, BDNF, BCL2, BAX, CDC42
43Toxoplasmosis20INFPIK3CA, PIK3CG, MYD88, BCL2, CD40LG, IL10
4414-3-3 Induced Apoptosis36INFMYD88, BID, BCL2, JUN, IL1B, IL1R1
45Apoptosis20INFPIK3CA, PIK3CG, MYD88, BID, BCL2, BAX
46Pathways in cancer20INFPIAS2, PIK3CA, PIK3CG, VEGFA, MYC, RAC1
47Tuberculosis20INFMYD88, RAF1, BID, BCL2, BAX, CD209
48Molecular Mechanisms of Cancer36INFPIK3CG, MYC, RAF1, BID, BDNF, BCL2
49Chagas disease (American trypanosomiasis)20INFPIK3CA, PIK3CG, SERPINE1, MYD88, CFLAR, JUN
50PEDF Induced Signaling36INFRAF1, BDNF, BCL2, BAX, CFLAR, CD80

Compounds for genes affiliated with Herpes Simplex

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
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Compounds related to herpes simplex according to GeneDecks:

(show top 50)    (show all 454)
idCompoundScoreTop Affiliating Genes
1calcium32 9 18 9 21.8NCL, PDCD6IP, RECK, REST, CNTN2, SELPLG
2atp32 16.5PIK3CA, NCL, RECK, KIF5B, KIF22, LMNA
3nitric oxide32 9 18 9 17.3LPO, MYD88, BID, ZFP36, PARK2, LGALS3
4methionine32 13.8RECK, VIM, LPO, BDNF, SCG5, LGALS1
5proline32 13.7VIM, MYD88, RAC1, CLU, PARK2, BDNF
6thymidine32 18 14.6PIK3CA, CNTN2, PCNA, MYC, MYBL2, RAF1
7glucose32 13.5LPO, MYO5A, BID, PARK2, LGALS1, XPO1
8hydrogen32 18 14.3SELPLG, LPO, RAC1, BDNF, UNG, SCG5
9ethanol32 34 9 18 9 16.5BID, CLU, BDNF, LBR, S100B, AZU1
10cholesterol32 9 18 9 15.4PIK3CA, RECK, GC, SELPLG, SERPINE1, LMNA
11iron32 18 13.1PICALM, RECK, VIM, LPO, PARK2, BDNF
12ganciclovir32 9 9 13.8VIM, CDKN3, FGFR2, IL2, IL4, MDK
13estradiol32 9 18 9 14.7PCNA, GC, SERPINE1, VIM, LPO, BDNF
14acth32 11.4BDNF, SCG5, LGALS3, ITIH4, MIF, IL1B
15allergens32 11.3SCG5, LGALS3, CD209, CD86, CD40LG, CD80
16ionomycin32 11.3CNTN2, LMNB1, RAG1, LCK, IL3, IL7
17vincristine32 34 9 9 14.2RECK, MGMT, FGF2, MAPK3, IFNA1, IFNB1
18peptidoglycan32 11.0PIK3CA, MYD88, IL10, IL15, IL1B, IL1R1
19vitamin d32 11.0GC, SERPINE1, VIM, CLU, BGLAP, SCG5
20sodium nitroprusside32 10.9PCNA, S100B, IRS1, IL13, APP, FASLG
21calcitriol32 42 9 18 9 14.9GC, MYC, CLU, BGLAP, XPO1, JUN
22corticosterone32 18 11.9BGLAP, BDNF, ITIH4, MIF, FGF2, IL1B
23mifepristone32 42 9 9 13.8ZFP36, LCK, BAX, LBR, JUN, CDK2
24agar32 10.7PIK3CA, CNTN2, VIM, RAC1, LGALS1, CDK2
25phosphotyrosine32 10.7PIK3CA, PIK3CG, RECK, RAF1, RAC1, SCG5
26zidovudine32 9 9 12.7CNTN2, MYC, LBR, MT-CO2, ITIH4, IL10
27polyethylene glycol32 10.5SERPINC1, APOE, MBP, IFNA2, F10, ERBB2
28ccl332 10.5IL10, IL13, IL15, IL18, IL1B, IL1R1
29sp 60012532 42 11.5PIK3CG, BID, IL13, IKBKB, CASP3, AKT1
30lipoteichoic acid32 10.5MYD88, IL10, IL18, IL1B, IL1R1, IL1RN
31matrigel32 10.3PIK3CA, PIK3CG, SERPINE1, VIM, VEGFA, RAC1
32paraffin32 10.0PCNA, VIM, VEGFA, MYC, CLU, BGLAP
33vinblastine32 9 9 12.0VIM, RAF1, BDNF, BCL2, BAX, JUN
34rosiglitazone32 9 18 9 12.8PIK3CA, PIK3CG, SERPINE1, LMNA, JUN, IRS1
35groalpha32 9.7IL10, IL13, IL18, IL1B, IL6, IL8
36indomethacin32 9 9 11.4PCNA, VIM, MYC, RAF1, BDNF, LGALS1
37carboplatin32 34 9 9 12.0VEGFA, BID, BCL2, MGMT, IL3, FASLG
38sodium arsenite32 8.9MYC, RAF1, LBR, CFLAR, JUN, IL2RA
39camptothecin32 42 9 9 INFPIK3CG, NCL, CNTN2, PCNA, MYC, LIG3
40c2ceramide32 INFPIK3CG, BAX, JUN, IRS1, IL1B, MAPK8
41cysteine32 INFRECK, CNTN2, PCNA, SELPLG, LPO, LMNB1
425-aza-2deoxycytidine32 INFPCNA, VIM, MYC, CLU, CFLAR, CDKN2A
43morphine32 9 9 INFCDK5, ITIH4, MIF, IL1RN, MAP2K1, CCL4
44cytochalasin d32 42 INFPIK3CG, VIM, RAF1, RAC1, LCK, CDC42
45troglitazone32 42 9 9 INFPIK3CG, SERPINE1, BCL2, BAX, CFLAR, JUN
46triptolide32 INFVEGFA, BCL2, BAX, JUN, CD86, IL1B
47bortezomib32 9 9 INFVEGFA, MYC, BID, BCL2, BAX, CFLAR
48pd 98,05932 INFPIK3CA, PIK3CG, NCL, RECK, SERPINE1, MYC
49dutp32 INFPCNA, CLU, BCL2, UNG, LGALS3, BAX
50ceramide32 INFPIK3CA, CNTN2, RAF1, BID, PARK2, LGALS1

GO Terms for genes affiliated with Herpes Simplex

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Sources:
12Gene Ontology
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Cellular components related to herpes simplex according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588613.8PILRA, PIK3CG, RECK, CNTN2, SELPLG, SERPINC1
2nucleoplasmGO:00565412.5SF3B2, RCC1, RCOR1, PCNA, LMNA, LMNB1
3extracellular regionGO:00557612.4PILRA, GC, SERPINC1, SERPINE1, VEGFA, CLU
4cell surfaceGO:00998611.3CNTN2, VEGFA, LILRB2, LGALS1, ULBP2, MSN
5extracellular spaceGO:00561510.8GC, SERPINC1, SERPINE1, VEGFA, LPO, LILRB2
6external side of plasma membraneGO:00989710.7CD86, CD40LG, CD83, ITGAL, IL13, IL2RB
7cytosolGO:005829INFPIK3CA, PIK3CG, PDCD6IP, REST, KIF22, GC
8nucleusGO:005634INFPIAS2, PICALM, KLHDC2, NCL, REST, KIF1A
9nucleolusGO:005730INFNCL, REST, SF3B2, RCC1, PCNA, SETD1A
10cytoplasmGO:005737INFPIK3CG, PDCD6IP, REST, KIF1A, KIAA0664, KIF22

Biological processes related to herpes simplex according to GeneDecks:

(show top 50)    (show all 74)
idNameGO IDScoreTop Affiliating Genes
1gene expressionGO:01046712.7SF3B2, SERPINE1, MYC, ZFP36, PABPC1, UBTF
2immune responseGO:00695512.3RAG1, LILRB2, ULBP2, CFP, CD86, MICB
3cell-cell signalingGO:00726711.9LILRB2, CD86, CD80, MLLT4, FGFR2, GRB2
4signal transductionGO:00716511.8PILRA, NCR1, NCR2, MYD88, RANGAP1, RAF1
5defense response to bacteriumGO:04274211.7CFP, MICA, IL10, IFNB1, IFNG, TNFRSF1A
6induction of apoptosisGO:00691711.5USP7, MX1, LCK, BAX, CDKN2A, IRF1
7DNA repairGO:00628111.5KIF22, PCNA, LIG4, LIG3, UNG, UBC
8positive regulation of transcription from RNA polymerase II promoterGO:04594411.3PIAS2, SERPINE1, VEGFA, MYC, MYD88, CLOCK
9response to virusGO:00961511.2MYD88, CLU, UNC93B1, MX1, ITCH, ISG20
10cytokine-mediated signaling pathwayGO:01922111.2MYD88, MX1, UBE2E1, UBC, ISG20, IRF1
11positive regulation of inflammatory responseGO:05072911.1SERPINE1, IL15, IL18, IL2, IL23A, CCL3
12positive regulation of tumor necrosis factor productionGO:03276011.1MYD88, IL18, IL23A, CCL3, CCL19, IFNG
13positive regulation of transcription, DNA-dependentGO:04589311.1PIAS2, PICALM, REST, NAA15, MYC, XRCC6
14type I interferon-mediated signaling pathwayGO:06033711.0MX1, ISG20, IRF1, IRF3, IRF7, IFIT1
15lipopolysaccharide-mediated signaling pathwayGO:03166311.0MYD88, IRF3, IL18, IL1B, MAPK3, MAPK14
16chemotaxisGO:00693510.9FGF2, IL4, MAPK14, MAPK1, MAP2K1, CCL4
17inflammatory responseGO:00695410.9PIK3CG, MYD88, RAC1, AZU1, CD40LG, ITCH
18positive regulation of apoptotic processGO:04306510.9REST, BID, CLU, BAX, ATM, IL1B
19Toll signaling pathwayGO:00806310.9MYD88, UBC, JUN, CDK1, IRF3, IRF7
20toll-like receptor 4 signaling pathwayGO:03414210.9MYD88, UBC, JUN, CDK1, IRF3, IRF7
21defense response to virusGO:05160710.8BCL2, CD86, IRF1, IRF3, MICA, IL29
22toll-like receptor 3 signaling pathwayGO:03413810.8UNC93B1, UBC, JUN, CDK1, IRF3, IRF7
23anti-apoptosisGO:00691610.8PIK3CA, MYD88, BDNF, BCL2, UBC, BAG3
24positive regulation of T cell proliferationGO:04210210.8LILRB2, CD1D, ITGAL, IL15, IL1B, IL23A
25TRIF-dependent toll-like receptor signaling pathwayGO:03566610.7UBC, JUN, CDK1, IRF3, IRF7, MAPK8
26MyD88-independent toll-like receptor signaling pathwayGO:00275610.7UBC, JUN, CDK1, IRF3, IRF7, MAPK8
27positive regulation of NF-kappaB transcription factor activityGO:05109210.6MYD88, CLU, UBC, IL1B, IL6, IKBKB
28humoral immune responseGO:00695910.6BCL2, CD83, IL6, IL7, CCL2, IFNB1
29response to glucocorticoid stimulusGO:05138410.4SERPINE1, BGLAP, IL10, IL1B, IL1RN, IL6
30toll-like receptor signaling pathwayGO:00222410.3MYD88, UBC, JUN, CD86, CDK1, MAPK8
31neuron apoptotic processGO:05140210.3LIG4, BID, BCL2, BAX, ATM, CDK5
32negative regulation of cell proliferationGO:00828510.3REST, RAF1, JUN, CDKN2A, CDKN3, IRF1
33G1/S transition of mitotic cell cycleGO:00008210.3RCC1, PCNA, BCL2, UBC, CDK3, CDK2
34toll-like receptor 1 signaling pathwayGO:03413010.2MYD88, UBC, JUN, CDK1, MAPK8, MAP2K2
35positive regulation of neuron apoptotic processGO:04352510.2BAX, ATM, JUN, CDK5, IL18, FASLG
36toll-like receptor 2 signaling pathwayGO:03413410.2MYD88, UBC, JUN, CDK1, MAPK8, MAP2K2
37MyD88-dependent toll-like receptor signaling pathwayGO:00275510.1MYD88, UBC, JUN, CDK1, MAPK8, MAP2K2
38response to drugGO:04249310.1MYC, BGLAP, BDNF, BCL2, LGALS1, LCK
39blood coagulationGO:00759610.1PIK3CA, PIK3CG, KIF22, RCOR1, SELPLG, SERPINC1
40MAPK cascadeGO:0001659.6MYC, RAF1, CDK1, IL18, IL1B, MAP2K2
41negative regulation of apoptotic processGO:0430668.0PIK3CG, SERPINE1, VEGFA, MYC, RAF1, CLU
42response to ethanolGO:045471INFBGLAP, BCL2, CDK1, MGMT, GRIN2B, IL13
43cellular response to mechanical stimulusGO:071260INFMYD88, IRF1, IL13, IL18, IL1B, FAS
44innate immune responseGO:045087INFPIK3CG, MYD88, CLEC4C, CLU, BCL2, UNC93B1
45apoptotic processGO:006915INFPDCD6IP, VIM, LMNA, LMNB1, RAF1, RAC1
46positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:043123INFMYD88, PARK2, LGALS1, UBC, S100B, CFLAR
47response to lipopolysaccharideGO:032496INFJUN, IL13, FASLG, FAS, IDO1, F3
48virus-host interactionGO:019048INFPILRA, PDCD6IP, SF3B2, RCOR1, VIM, USP7
49activation of pro-apoptotic gene productsGO:008633INFMYC, BID, BCL2, BAX, CDK5, FASLG
50induction of apoptosis by intracellular signalsGO:008629INFMYC, BID, CLU, BCL2, BAX, MAPK8

Molecular functions related to herpes simplex according to GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:04280311.9TGFB2, TKT, TYR, NFKB1, NOS2, CREB3
2receptor bindingGO:00510211.8NTF3, TNFSF8, TNFSF14, HLA-B, HNF4A, CRAT
3ATP bindingGO:00552411.3DTYMK, SRPK1, OAS1, RNASEL, EGFR, ABCC5
4protein kinase activityGO:00467211.1CCL5, IKBKB, HSPB8, AKT1, DYRK1A, SRPK1
5transcription regulatory region DNA bindingGO:04421210.9TBP, TBX21, SP1, CTCF, NFKB1, HDAC4
6cell adhesion molecule bindingGO:05083910.7GRIN2B, PVR, PVRL1, PVRL2, MLLT4, ITGAL
7cytokine activityGO:00512510.3CSF2, IL1B, IL18, IL15, IL13, IL10
8protease bindingGO:0020209.8TNF, TNFRSF1A, ELANE, CST3, CSTA, TP53
9transcription factor bindingGO:0081349.6CREBBP, SP100, SP1, DAXX, NFKBIA, CSNK2B
10protein heterodimerization activityGO:0469829.1PVRL1, TGFB2, TLR2, TYR, TAP1, POLA1
11identical protein bindingGO:042802INFDYNLT3, DYNLT1, TNF, TP53, ERBB2, AIRE
12protein bindingGO:005515INFTGFB2, EIF4B, EIF4A2, EIF2AK3, EIF2AK2, EIF2A

Sources for Herpes Simplex

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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