MCID: HRP006
MIFTS: 66

Herpes Simplex malady

Infectious diseases, Oral diseases, Reproductive diseases, Rare diseases categories

Summaries for Herpes Simplex

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9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Herpes is an infection that is caused by a herpes simplex virus (hsv). oral herpes causes cold sores around the mouth or face. genital herpes affects the genitals, buttocks or anal area. genital herpes is a sexually transmitted disease (std). it affects the genitals, buttocks or anal area. other herpes infections can affect the eyes, skin, or other parts of the body. the virus can be dangerous in newborn babies or in people with weak immune systems. there are two types of hsv: hsv type 1 most commonly causes cold sores. it can also cause genital herpes. hsv type 2 is the usual cause of genital herpes, but it also can infect the mouth. hsv spreads through direct contact. some people have no symptoms. others get sores near the area where the virus has entered the body. they turn into blisters, become itchy and painful, and then heal. most people have outbreaks several times a year. over time, you get them less often. medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards: Herpes Simplex, also known as herpesvirus hominis disease, is related to encephalitis and genital herpes. An important gene associated with Herpes Simplex is UNC93B1 (unc-93 homolog B1 (C. elegans)), and among its related pathways are Trafficking and processing of endosomal TLR and Nectin adhesion pathway. The drugs benzocaine and methylene blue and the compounds inosine monophosphate and poly(i-c) have been mentioned in the context of this disorder. Affiliated tissues include h, genitalia and face, and related mouse phenotypes are liver/biliary system and immune system.

Disease Ontology:9 A viral infectious disease that results in formation of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in human herpesvirus 1 or has material basis in human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia:66 Herpes simplex (Greek: ????? herp?s, \"creeping\" or \"latent\") is a viral disease from the... more...

Aliases & Classifications for Herpes Simplex

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9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH
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Classifications:



Aliases & Descriptions:

herpes simplex 9 11 46 35
herpesvirus hominis disease 9
herpes simplex infections 63


External Ids:

Disease Ontology9 DOID:8566
ICD9CM28 054
MeSH36 D006561

Related Diseases for Herpes Simplex

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Herpes Simplex:



Diseases related to herpes simplex

Symptoms for Herpes Simplex

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Drugs & Therapeutics for Herpes Simplex

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Herpes Simplex

Drug clinical trials:

Search ClinicalTrials for Herpes Simplex

Search NIH Clinical Center for Herpes Simplex

Search CenterWatch for Herpes Simplex

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Herpes Simplex

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Anatomical Context for Herpes Simplex

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Herpes Simplex:

34
Skin, T cells, Eye, Brain, Testes, Liver, Endothelial, Lung, Breast, Prostate, Monocytes, B cells, Bone, Colon, Bone marrow, Temporal lobe, Nk cells, Thyroid, Tongue, Myeloid, Trigeminal ganglion, Cortex, Heart, Dorsal root ganglion, Tonsil, Thalamus, Cervix, Placenta, Whole blood, Lymph node, Thymus, Spinal cord, Kidney, Pancreas, Pituitary, Ovary

FMA organs/tissues related to Herpes Simplex:

15
H, Genitalia, Face, Mouth

Animal Models for Herpes Simplex or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Herpes Simplex:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.5UNC93B1, TICAM1, TBK1, TKT, TRAF3
2MP:00053879.3DARC, TLR3, UNC93B1, TNFRSF14, TBK1, TRAF3
3MP:00053768.8TRAF3, DARC, TLR3, TBK1, PVRL1, UNC93B1

Publications for Herpes Simplex

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53PubMed
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Articles related to Herpes Simplex:

(show top 50)    (show all 2625)
idTitleAuthorsYear
1
Vulvar pseudoepitheliomatous hyperplasia associated with herpes simplex virus type II mimicking cancer in an immunocompromised patient. (23937292)
2014
2
Methods for screening and profiling inhibitors of herpes simplex viruses. (23821277)
2013
3
Herpes simplex encephalitis presenting with normal CSF analysis. (24169394)
2013
4
Herpes Simplex epithelial keratitis associated with daily disposable contact lens wear. (24333040)
2013
5
Immunological control of herpes simplex virus infections. (23943467)
2013
6
Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes. (24101547)
2013
7
Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis. (24370835)
2013
8
Postpartum herpes simplex virus endometritis and disseminated infection in both mother and neonate. (22825269)
2012
9
Herpes simplex virus antigens directly activate NK cells via TLR2, thus facilitating their presentation to CD4 T lymphocytes. (22467654)
2012
10
Herpes simplex encephalitis presenting after steroid treatment of panuveitis. (21770880)
2011
11
Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo. (21632763)
2011
12
Auditory and vestibular defects induced by experimental labyrinthitis following herpes simplex virus in mice. (21526906)
2011
13
Gianotti-Crosti syndrome associated with herpes simplex virus type 1 gingivostomatitis. (21238841)
2011
14
New-onset herpes simplex virus keratitis after cataract surgery. (19092420)
2009
15
Delivery of Interferon-gamma by an adenovirus vector blocks herpes simplex virus Type 1 reactivation in vitro and in vivo independent of RNase L and double-stranded RNA-dependent protein kinase pathways. (19042034)
2009
16
Comparison of nested-polymerase chain reaction and virus culture for the diagnosis of genital herpes simplex virus infection. (18581019)
2008
17
Chronic sequelae of herpes simplex encephalitis demonstrated on interictal F-18 FDG PET/CT. (18496462)
2008
18
Immunohistochemical expression of p16 and herpes simplex virus type 2 in squamous intraepithelial lesions and cervical cancer]. (19142477)
2008
19
Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. (17267483)
2007
20
Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. (17085599)
2006
21
Consequences of chemoresistance for the herpes simplex virus thymidine kinase/ganciclovir-induced bystander effect in a human small cell lung cancer cell line model. (15816546)
2005
22
Potential nectin-1 binding site on herpes simplex virus glycoprotein d. (15613355)
2005
23
Plasmacytoid dendritic cell reconstitution following bone marrow transplantation: subnormal recovery and functional deficit of IFN-alpha/beta production in response to herpes simplex virus. (15767787)
2005
24
ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export. (15767397)
2005
25
Herpes simplex virus type 2 acute retinal necrosis 9 years after neonatal herpes. (15973328)
2005
26
Recurrent herpes simplex type 2 virus (Mollaret) meningitis. (15243021)
2004
27
Increased susceptibility of herpes simplex virus-1 growth in phytohemagglutinin-activated T lymphocytes caused by upregulation of herpesvirus entry mediator A mRNA expression. (15044831)
2004
28
Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies virus entry. (12072519)
2002
29
Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation. (12414939)
2002
30
Transverse myelitis associated with herpes simplex virus infection. (11732777)
2001
31
Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations-relevance for the incidence of genital herpes. (10797375)
2000
32
Lower interleukin-2 and higher serum tumor necrosis factor-a levels are associated with perimenstrual, recurrent, facial Herpes simplex infection in young women. (11022124)
2000
33
Classification of herpes simplex virus keratitis and anterior uveitis. (10090358)
1999
34
Identification of phosphorylation sites within the herpes simplex virus tegument protein VP22. (10364384)
1999
35
Bell palsy: a herpes simplex mononeuritis? (9677123)
1998
36
Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells. (9032307)
1997
37
High interferon alpha levels in placenta, maternal, and cord blood suggest a protective effect against intrauterine herpes simplex virus infection. (9139085)
1997
38
Inhibition of herpes simplex virus type 1 immediate-early gene expression by alpha interferon is not VP16 specific. (8709261)
1996
39
High-dose ocular infection with a herpes simplex virus type 1 ICP34.5 deletion mutant produces no corneal disease or neurovirulence yet results in wild-type levels of spontaneous reactivation. (8627763)
1996
40
Intranasal immunization against herpes simplex virus infection by using a recombinant glycoprotein D fused with immunomodulating proteins, the B subunit of Escherichia coli heat-labile enterotoxin and interleukin-2. (8388365)
1993
41
Purification and characterization of the herpes simplex virus type 2-encoded uracil-DNA glycosylase. (8393229)
1993
42
Intra-uterine and neonatal herpes simplex virus infection. (1803497)
1991
43
Induction of encephalitis in SJL mice by intranasal infection with herpes simplex virus type 1: a possible model of herpes simplex encephalitis in humans. (1849158)
1991
44
Recurrent herpetic keratitis: failure to detect herpes simplex virus infection using the Syva MicroTrak HSV1/HSV2 direct specimen identification/typing test. (1963928)
1990
45
Neonatal herpes simplex viremia. (2839814)
1988
46
Non-herpes simplex encephalitis is early exclusion of herpes simplex etiology possible? (2824204)
1987
47
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. (6985228)
1982
48
HLA antigens in recurrent stromal herpes simplex virus keratitis. (7356786)
1980
49
Antiviral chemotherapy and neonatal herpes simplex virus infecition: a pilot study--experience with adenine arabinoside (ARA-A). (165453)
1975
50
Acute necrotizing encephalitis caused by herpes simplex virus. Two cases treated with 5-iodo-2-deoxyuridine. (5110953)
1971

Variations for Herpes Simplex

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Expression for genes affiliated with Herpes Simplex

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Herpes Simplex

Search GEO for disease gene expression data for Herpes Simplex.

Pathways for genes affiliated with Herpes Simplex

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 58SinoBiological, 55R&D Systems, 54QIAGEN, 31KEGG, 5Cell Signaling Technology, 61Thomson Reuters
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Pathways related to Herpes Simplex according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2UNC93B1, TLR3
210.1PVRL2, PVRL1
3
Show member pathways
10.0TBK1, TNFRSF14, TLR3
4
Show member pathways
10.0CREB3, TBK1, TRAF3
5
Show member pathways
9.9TLR3, TICAM1, TBK1
69.8TRAF3, TBK1, TICAM1, TLR3
7
Show member pathways
9.8TLR3, TICAM1, TBK1, TRAF3
89.8TLR3, TICAM1, TBK1, TRAF3
9
Show member pathways
9.6TLR3, TNFRSF14, CREB3, TBK1, TRAF3
10
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.6TLR3, TICAM1, CREB3, TBK1, TRAF3
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.5TRAF3, TBK1, IL36G, TICAM1, TLR3
12
Show member pathways
8.8TRAF3, TLR3, HCFC2, HCFC1, TNFRSF14, TICAM1

Compounds for genes affiliated with Herpes Simplex

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46Novoseek, 25HMDB
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Compounds related to Herpes Simplex according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1inosine monophosphate4610.1TBK1, TLR3
2poly(i-c)469.9TLR3, TICAM1, TBK1
3rantes469.6TBK1, TICAM1, TLR3, DARC
4heparan sulfate46 2510.6PVRL1, PVRL2, GGH
5tyrosine468.9TRAF3, TKT, TBK1, AAVS1, PVRL2, PVRL1

GO Terms for genes affiliated with Herpes Simplex

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17Gene Ontology
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Cellular components related to Herpes Simplex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:0100089.8TBK1, TICAM1, TLR3
2Golgi membraneGO:0001399.4TLR3, UNC93B1, HS3ST4, CREB3
3cytosolGO:0058299.1TICAM1, CREB3, TBK1, GGH, TKT, TRAF3

Biological processes related to Herpes Simplex according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1release from viral latencyGO:01904610.5CREB3, HCFC1
2positive regulation of chemokine biosynthetic processGO:04508010.4TLR3, TICAM1
3tumor necrosis factor-mediated signaling pathwayGO:03320910.3TRAF3, TNFRSF14
4positive regulation of interferon-beta productionGO:03272810.3TLR3, TBK1
5positive regulation of interferon-beta biosynthetic processGO:04535910.3TBK1, TICAM1, TLR3
6I-kappaB kinase/NF-kappaB signalingGO:00724910.2TBK1, TICAM1, TLR3
7negative regulation of type I interferon productionGO:03248010.2TBK1, TRAF3
8positive regulation of interleukin-6 productionGO:03275510.2IL36G, TICAM1, TLR3
9positive regulation of I-kappaB kinase/NF-kappaB signalingGO:04312310.1TBK1, TICAM1, TLR3
10response to exogenous dsRNAGO:04333010.1TICAM1, TLR3
11TRIF-dependent toll-like receptor signaling pathwayGO:03566610.1TLR3, TICAM1, TBK1, TRAF3
12adherens junction organizationGO:03433210.1PVRL2, PVRL1
13MyD88-independent toll-like receptor signaling pathwayGO:00275610.1TLR3, TICAM1, TBK1, TRAF3
14defense response to virusGO:05160710.1TLR3, UNC93B1, TICAM1, TBK1
15toll-like receptor 4 signaling pathwayGO:03414210.1TRAF3, TBK1, TICAM1, TLR3
16defense response to Gram-positive bacteriumGO:05083010.0TNFRSF14, TBK1
17toll-like receptor 3 signaling pathwayGO:03413810.0TRAF3, TBK1, TICAM1, UNC93B1, TLR3
18toll-like receptor signaling pathwayGO:00222410.0TLR3, UNC93B1, TICAM1, TBK1, TRAF3
19innate immune responseGO:0450879.9TLR3, UNC93B1, TICAM1, TBK1, TRAF3
20viral processGO:0160329.8HCFC2, TNFRSF14, CREB3, TBK1
21positive regulation of tumor necrosis factor productionGO:0327609.8TICAM1, TLR3
22inflammatory responseGO:0069549.8DARC, TLR3, TICAM1, IL36G, TBK1

Molecular functions related to Herpes Simplex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coreceptor activityGO:01502610.1PVRL2, PVRL1
2virus receptor activityGO:00161810.0PVRL2, PVRL1, TNFRSF14
3cell adhesion molecule bindingGO:0508399.8PVRL1, PVRL2
4protein homodimerization activityGO:0428039.7TKT, CREB3, PVRL2, PVRL1
5protein bindingGO:0055158.5TICAM1, TNFRSF14, HCFC1, TLR3, PVRL1, PVRL2

Products for genes affiliated with Herpes Simplex

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  • Antibodies
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Sources for Herpes Simplex

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet