MCID: HRP009
MIFTS: 56

Herpes Simplex Encephalitis malady

Genetic diseases, Rare diseases, Neuronal diseases, Fetal diseases, Blood diseases, Infectious diseases categories

Aliases & Classifications for Herpes Simplex Encephalitis

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Sources:
41NIH Rare Diseases, 47Orphanet, 60UMLS, 26ICD10 via Orphanet, 25ICD10
See all sources

Herpes Simplex Encephalitis, Aliases & Descriptions:

Name: Herpes Simplex Encephalitis 41 47
Anterior Encephalocele 41 47
Frontal Encephalocele 41 47
Herpetic Encephalitis 41 47
 
Herpes Simplex Neuroinvasion 47
Herpes Encephalitis 60
Hsv Encephalitis 47


Classifications:



Characteristics (Orphanet epidemiological data):

47
herpes simplex encephalitis:
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age


External Ids:

Orphanet47 1931, 1930
ICD10 via Orphanet26 Q01.0, B00.4+, G05.1*
ICD1025 Q01.0

Summaries for Herpes Simplex Encephalitis

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MalaCards based summary: Herpes Simplex Encephalitis, also known as anterior encephalocele, is related to herpes simplex and encephalitis, and has symptoms including macrocephaly, encephalocele and hydrocephalus. An important gene associated with Herpes Simplex Encephalitis is UNC93B1 (unc-93 homolog B1 (C. elegans)), and among its related pathways are Trafficking and processing of endosomal TLR and NF-kappa B signaling pathway. The drugs acyclovir and acyclovir sodium and the compounds inosine monophosphate and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and testes, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Related Diseases for Herpes Simplex Encephalitis

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Diseases in the Herpes Simplex Encephalitis family:

Herpes Simplex Encephalitis 2 Herpes Simplex Encephalitis 1
Herpes Simplex Encephalitis 3

Diseases related to Herpes Simplex Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex32.8UNC93B1, TLR3
2encephalitis32.8UNC93B1, TLR3
3creutzfeldt-jakob disease30.4S100B, APOE
4pneumonia30.1IL2RB, ELANE, TLR3
5neonatal herpes10.8
6encephalocele10.7
7retinitis10.7
8herpes simplex encephalitis 210.6
9herpes simplex encephalitis 110.6
10herpes simplex encephalitis 310.5
11cerebritis10.5
12kluver-bucy syndrome10.5
13meningitis10.5
14glioblastoma10.5
15encephalopathy, acute, infection-induced 610.4
16status epilepticus10.4
17neuronitis10.4
18melas syndrome10.4
19neurosyphilis10.4
20abdominal aortic aneurysm10.3APOE
21febrile infection-related epilepsy syndrome10.3
22medulloblastoma10.2
23breast cancer10.2
24hiv-110.2
25immunodeficiency 31b, mycobacterial and viral infections, autosomal recessive10.2
26multiple myeloma10.2
27burns10.2
28hepatitis10.2
29hepatitis b10.2
30neutropenia10.2
31acute hemorrhagic leukoencephalitis10.2
32diabetes insipidus10.2
33japanese encephalitis10.2
34murray valley encephalitis10.2
35western equine encephalitis10.2
36meningoencephalitis10.2
37progressive multifocal leukoencephalopathy10.2
38viral encephalitis10.2
39retrograde amnesia10.2
40mumps10.2
41neuroretinitis10.2
42la crosse encephalitis10.2
43tick-borne encephalitis10.2
44central nervous system lymphoma10.2
45rabies10.2
46alexia10.2
47acute retinal necrosis syndrome10.2
48complex partial epilepsy10.2
49agraphia10.2
50sick sinus syndrome10.2

Graphical network of the top 20 diseases related to Herpes Simplex Encephalitis:



Diseases related to herpes simplex encephalitis

Symptoms for Herpes Simplex Encephalitis

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Symptoms:

 47 (show all 11)
  • macrocephaly/macrocrania/megalocephaly/megacephaly
  • encephalocele/exencephaly
  • scalp/skull defect
  • spina bifida
  • myelomeningocele
  • hydrocephaly
  • dolichocephaly/scaphocephaly
  • hypertelorism
  • corpus callosum/septum pellucidum total/partial agenesis
  • intracranial/cerebral calcifications
  • seizures/epilepsy/absences/spasms/status epilepticus

HPO human phenotypes related to Herpes Simplex Encephalitis:

(show all 10)
id Description Frequency HPO Source Accession
1 macrocephaly hallmark (90%) HP:0000256
2 encephalocele hallmark (90%) HP:0002084
3 hydrocephalus typical (50%) HP:0000238
4 skull defect typical (50%) HP:0001362
5 myelomeningocele typical (50%) HP:0002475
6 dolichocephaly occasional (7.5%) HP:0000268
7 hypertelorism occasional (7.5%) HP:0000316
8 seizures occasional (7.5%) HP:0001250
9 cerebral calcification occasional (7.5%) HP:0002514
10 aplasia/hypoplasia of the corpus callosum occasional (7.5%) HP:0007370

Drugs & Therapeutics for Herpes Simplex Encephalitis

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Drug clinical trials:

Search ClinicalTrials for Herpes Simplex Encephalitis

Search NIH Clinical Center for Herpes Simplex Encephalitis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Herpes Simplex Encephalitis

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Anatomical Context for Herpes Simplex Encephalitis

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MalaCards organs/tissues related to Herpes Simplex Encephalitis:

31
Brain, Temporal lobe, Testes, Eye, Cortex, T cells, Heart, Liver, Lung, Breast, Skin, B cells, Pituitary

Animal Models for Herpes Simplex Encephalitis or affiliated genes

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MGI Mouse Phenotypes related to Herpes Simplex Encephalitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.8TRAF3, TBK1, APOE, UNC93B1
2MP:00053707.9UNC93B1, APOE, TICAM1, IL2RB, TBK1, TRAF3
3MP:00053766.9TLR3, UNC93B1, APOE, TICAM1, ELANE, TBK1
4MP:00053976.8TRAF3, TLR3, UNC93B1, APOE, TICAM1, ELANE
5MP:00053876.8TLR3, UNC93B1, APOE, TICAM1, ELANE, IL2RB
6MP:00107686.6TLR3, UNC93B1, APOE, TICAM1, ELANE, IL2RB

Publications for Herpes Simplex Encephalitis

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Articles related to Herpes Simplex Encephalitis:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Acute herpes simplex encephalitis in pregnancy. (25546520)
2014
2
Teaching NeuroImages: Infantile herpes simplex encephalitis. (25114204)
2014
3
Unusual Clinical Presentation and Role of Decompressive Craniectomy in Herpes Simplex Encephalitis. (25156666)
2014
4
Acyclovir-resistant herpes simplex encephalitis in a patient treated with anti-tumor necrosis factor-I+ monoclonal antibodies. (24257111)
2014
5
Herpes simplex encephalitis presenting with normal CSF analysis. (24169394)
2013
6
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome mimicking herpes simplex encephalitis on imaging studies. (23493219)
2013
7
A case of late herpes simplex encephalitis relapse. (23757375)
2013
8
Intracerebral hematoma complicating herpes simplex encephalitis. (23886833)
2013
9
Herpes simplex encephalitis presenting after steroid treatment of panuveitis. (21770880)
2011
10
APOBEC1-mediated editing and attenuation of herpes simplex virus 1 DNA indicate that neurons have an antiviral role during herpes simplex encephalitis. (21775448)
2011
11
Intravitreal Foscarnet Therapy for Acyclovir-Resistant Acute Retinal Necrosis After Herpes Simplex Encephalitis. (20337281)
2010
12
Herpes simplex encephalitis in older adults. (20122069)
2010
13
MRI deterioration in herpes simplex encephalitis despite clinical recovery. (19590384)
2009
14
Chronic sequelae of herpes simplex encephalitis demonstrated on interictal F-18 FDG PET/CT. (18496462)
2008
15
Herpes simplex encephalitis as an initial presentation of Creutzfeldt-Jakob disease. (18605370)
2008
16
Choreoathetosis after herpes simplex encephalitis with basal ganglia involvement on MRI. (18378549)
2008
17
Quantitative demonstration of intrathecal synthesis of high affinity immunoglobulin G in herpes simplex encephalitis using affinity-mediated immunoblotting. (17303253)
2007
18
Herpes simplex encephalitis presenting with bilateral hippocampal lesions on magnetic resonance imaging, simultaneously complicated by small cell lung carcinoma. (16258223)
2005
19
Herpes simplex encephalitis: some interesting presentations. (14652453)
2003
20
Limits of early diagnosis of herpes simplex encephalitis in children: a retrospective study of 38 cases. (12746782)
2003
21
Herpes simplex encephalitis in North West India. (11799408)
2001
22
Bilateral necrotizing herpetic retinopathy three years after herpes simplex encephalitis following pulse corticosteroid treatment. (10546950)
1999
23
Role of serology in the diagnosis of herpes simplex encephalitis. (10862294)
1999
24
Quantitation of herpes simplex virus DNA in cerebrospinal fluid of patients with herpes simplex encephalitis by the polymerase chain reaction. (9126688)
1997
25
Relapse and movement disorder after herpes simplex encephalitis. (9203073)
1997
26
The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. The EU Concerted Action on Virus Meningitis and Encephalitis. (8890768)
1996
27
Hypomanic symptoms caused by herpes simplex encephalitis. (8960713)
1996
28
Mild form of acute herpes simplex encephalitis in childhood. (8579225)
1995
29
Acyclovir-induced neutropenia in an infant with herpes simplex encephalitis: case report. (7548511)
1995
30
Alexia without either agraphia or hemianopia in temporal lobe lesion due to herpes simplex encephalitis. (7550926)
1995
31
Herpes simplex encephalitis. (7836269)
1994
32
Symmetrical external capsule lesions in a patient with herpes simplex encephalitis. (7969800)
1994
33
Induction of encephalitis in SJL mice by intranasal infection with herpes simplex virus type 1: a possible model of herpes simplex encephalitis in humans. (1849158)
1991
34
SPECT and MR imaging in herpes simplex encephalitis. (1885800)
1991
35
Correlation of early MRI with CT scan, EEG, and CSF: analyses in a case of biopsy-proven herpes simplex encephalitis. (1661678)
1991
36
Herpes simplex encephalitis: an overview. (1795386)
1991
37
Herpes simplex encephalitis following a skull fracture. (1659620)
1991
38
Neurological outcome after a severe herpes simplex encephalitis treated with acyclovir and beta-interferon. Time course of intracranial pressure. (2325356)
1990
39
Herpes simplex encephalitis. (3278564)
1988
40
Non-herpes simplex encephalitis is early exclusion of herpes simplex etiology possible? (2824204)
1987
41
Is serodiagnosis of herpes simplex encephalitis safe? (3451222)
1987
42
No, brain biopsy need not be done in every patient suspected of having herpes simplex encephalitis. (3675262)
1987
43
Neonatal herpes simplex encephalitis: correlation of clinical and CT findings. (3809499)
1987
44
Herpes simplex encephalitis in third trimester of pregnancy: successful outcome for mother and child. (3627453)
1987
45
The in situ cellular immune response in acute herpes simplex encephalitis. (3789090)
1986
46
Brain biopsy in cases of neonatal herpes simplex encephalitis. (2987747)
1985
47
Necropsy study of the olfactory portal of entry in herpes simplex encephalitis. (6100934)
1983
48
Liver disorder in herpes simplex encephalitis. (7169672)
1982
49
Diagnosis of herpes simplex encephalitis. A comparison between electroencephalography and computed tomography findings. (7148389)
1982
50
Partial KlA1ver-Bucy Syndrome following probably herpes simplex encephalitis. (91669)
1979

Variations for Herpes Simplex Encephalitis

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Clinvar genetic disease variations for Herpes Simplex Encephalitis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1UNC93B1UNC93B1, 4-BP DEL, 1034CTTTdeletionrisk factor
2UNC93B1UNC93B1, 781G-Asingle nucleotide variantrisk factor
3TRAF3NM_145725.2(TRAF3): c.352C> T (p.Arg118Trp)single nucleotide variantrisk factorrs143813189GRCh37Chr 14, 103342015: 103342015
4TICAM1NM_182919.3(TICAM1): c.421C> T (p.Arg141Ter)single nucleotide variantrisk factorrs387907307GRCh37Chr 19, 4817969: 4817969
5TICAM1NM_182919.3(TICAM1): c.557C> T (p.Ser186Leu)single nucleotide variantrisk factorrs146550489GRCh37Chr 19, 4817833: 4817833
6TLR3NM_003265.2(TLR3): c.1660C> T (p.Pro554Ser)single nucleotide variantrisk factorrs121434431GRCh37Chr 4, 187004500: 187004500

Expression for genes affiliated with Herpes Simplex Encephalitis

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Search GEO for disease gene expression data for Herpes Simplex Encephalitis.

Pathways for genes affiliated with Herpes Simplex Encephalitis

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Pathways related to Herpes Simplex Encephalitis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8UNC93B1, TLR3
29.7TICAM1, TRAF3
3
Show member pathways
9.3TLR3, TBK1, TRAF3
4
Show member pathways
9.0TRAF3, S100B, TBK1
5
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.9TLR3, TRAF3, TBK1, TICAM1
68.9TICAM1, TBK1, TLR3, TRAF3
78.9TBK1, TLR3, TICAM1, TRAF3
8
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.9TICAM1, TRAF3, TLR3, TBK1
9
Show member pathways
8.6TLR3, TICAM1, TBK1, S100B
10
Show member pathways
8.4TRAF3, TBK1, IL2RB, TICAM1, TLR3
11
Show member pathways
8.3TRAF3, S100B, TBK1, TICAM1, TLR3

Compounds for genes affiliated with Herpes Simplex Encephalitis

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Compounds related to Herpes Simplex Encephalitis according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1inosine monophosphate4310.0TBK1, TLR3
22,5-oligoadenylate439.9TLR3, IL2RB
3edss439.7S100B, APOE
4ifn-alpha439.7IL2RB, TLR3
5spec-t439.7IL2RB, APOE
6poly(i-c)439.7TLR3, TICAM1, TBK1
7exotoxin-a439.5ELANE, IL2RB
8cuprophan439.5ELANE, IL2RB
9polysulfone439.5IL2RB, ELANE
10guanidine43 24 1211.4ELANE, APOE
11dermatan sulfate439.4ELANE, APOE
12pentoxifylline43 1210.3IL2RB, ELANE
13gtp43 2810.2TRAF3, S100B, IL2RB
14endotoxin439.2TLR3, ELANE, IL2RB
15rantes439.2TBK1, IL2RB, TICAM1, TLR3
16neopterin439.1IL2RB, ELANE
17phospholipid439.1S100B, IL2RB, APOE
18thymidine43 2410.0IL2RB, S100B, TRAF3
19thyroxine43 2410.0IL2RB, ELANE, APOE
20aspirin43 49 28 2412.0IL2RB, ELANE, APOE
21cyclic amp43 2410.0TRAF3, S100B, IL2RB
22valine438.9S100B, ELANE, APOE
23threonine438.9IL2RB, TBK1, S100B, TRAF3
24norepinephrine43 24 1210.8ELANE, IL2RB, S100B
25aspartate438.8APOE, IL2RB, S100B, TRAF3
26acetylcholine43 49 28 24 1212.8APOE, ELANE, S100B
27alanine438.8TRAF3, S100B, IL2RB, APOE
28glutamine438.7APOE, ELANE, S100B
29creatinine438.7S100B, IL2RB, APOE
30lactate438.7S100B, IL2RB, ELANE
31lipid438.6APOE, IL2RB, S100B, TRAF3
32tyrosine438.5TRAF3, S100B, TBK1, IL2RB, TLR3
33retinoic acid43 249.5S100B, IL2RB, ELANE, TLR3
34oxygen43 249.5ELANE, IL2RB, S100B, TRAF3
35cyclosporin a43 28 5910.4S100B, IL2RB, ELANE, APOE
36heparin43 28 24 1211.2APOE, ELANE, S100B
37serine436.8TRAF3, TLR3, APOE, TICAM1, ELANE, IL2RB

GO Terms for genes affiliated with Herpes Simplex Encephalitis

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Cellular components related to Herpes Simplex Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:00100089.3TBK1, TICAM1, TLR3

Biological processes related to Herpes Simplex Encephalitis according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine biosynthetic processGO:004508010.0TICAM1, TLR3
2positive regulation of interferon-beta productionGO:00327289.9TBK1, TLR3
3response to exogenous dsRNAGO:00433309.9TICAM1, TLR3
4positive regulation of tumor necrosis factor productionGO:00327609.8TICAM1, TLR3
5negative regulation of type I interferon productionGO:00324809.8TBK1, TRAF3
6positive regulation of interleukin-6 productionGO:00327559.7TLR3, TICAM1
7positive regulation of interferon-beta biosynthetic processGO:00453599.6TBK1, TICAM1, TLR3
8regulation of neuronal synaptic plasticityGO:00481689.6S100B, APOE
9I-kappaB kinase/NF-kappaB signalingGO:00072499.5TLR3, TICAM1, TBK1
10inflammatory responseGO:00069549.3TBK1, TICAM1, TLR3
11positive regulation of type I interferon productionGO:00324819.3TBK1, TICAM1
12defense response to virusGO:00516079.2TLR3, UNC93B1, TICAM1, TBK1
13TRIF-dependent toll-like receptor signaling pathwayGO:00356669.2TRAF3, TBK1, TICAM1, TLR3
14MyD88-independent toll-like receptor signaling pathwayGO:00027569.2TLR3, TICAM1, TBK1, TRAF3
15toll-like receptor 4 signaling pathwayGO:00341429.2TRAF3, TBK1, TICAM1, TLR3
16cellular calcium ion homeostasisGO:00068749.1ELANE, APOE
17negative regulation of inflammatory responseGO:00507289.0ELANE, APOE
18toll-like receptor 3 signaling pathwayGO:00341388.9TRAF3, TBK1, TICAM1, UNC93B1, TLR3
19positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431238.9S100B, TBK1, TICAM1, TLR3
20toll-like receptor signaling pathwayGO:00022248.9TLR3, UNC93B1, TICAM1, TBK1, TRAF3
21innate immune responseGO:00450878.3TLR3, UNC93B1, TICAM1, TBK1, S100B, TRAF3

Molecular functions related to Herpes Simplex Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tau protein bindingGO:00481569.0S100B, APOE
2protein bindingGO:00055156.9TRAF3, S100B, TBK1, ELANE, TICAM1, APOE

Products for genes affiliated with Herpes Simplex Encephalitis

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  • Antibodies
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  • Kits and Assays

Sources for Herpes Simplex Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet