MCID: HRP004
MIFTS: 61

Herpes Zoster malady

Summaries for Herpes Zoster

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8Disease Ontology, 33MedlinePlus, 3CDC, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Shingles is a disease caused by the varicella-zoster virus - the same virus that causes chickenpox. after you have chickenpox, the virus stays in your body. it may not cause problems for many years. as you get older, the virus may reappear as shingles. although it is most common in people over age 50, anyone who has had chickenpox is at risk. unlike chickenpox, you can't catch shingles from someone who has it. early signs of shingles include burning or shooting pain and tingling or itching, usually on one side of the body or face. the pain can be mild to severe. rashes or blisters appear anywhere from one to 14 days later. if shingles appears on your face, it may affect your vision or hearing. the pain of shingles may last for weeks, months, or even years after the blisters have healed. there is no cure for shingles. early treatment with medicines that fight the virus may help. these medicines may also help prevent lingering pain. a vaccine may prevent shingles or lessen its effects. the vaccine is recommended for people 60 or over. in some cases doctors may give it to people ages 50 to 59. nih: national institute of allergy and infectious diseases

MalaCards: Herpes Zoster, also known as shingles, is related to geniculate herpes zoster and retinitis, and has symptoms including headache, fever and malaise. An important gene associated with Herpes Zoster is FCGR3A (Fc fragment of IgG, low affinity IIIa, receptor (CD16a)), and among its related pathways is Hematopoietic cell lineage. The drugs capsaicin and famciclovir and the compounds estrogen and bv-arau have been mentioned in the context of this disorder. Affiliated tissues include nerve fiber, skin and colon, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in infection located in nerve fiber, has material basis in human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. the virus is transmitted by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. the infection has symptom rash which is followed by blisters, has symptom headache, has symptom fever, has symptom malaise, has symptom itching, has symptom burning pain, and has symptom paresthesia.

CDC:3 Shingles, also known as zoster or herpes zoster, is a painful skin rash caused by the varicella zoster virus, the same virus that causes chickenpox. Nearly 1 out of every 3 people in the United States will develop shingles. Anyone who has recovered from chickenpox may develop shingles; even children can get shingles. However, the risk of getting the disease increases as a person gets older. About half of all cases occur among men and women who are 60 years old or older... more

NINDS:43 Shingles (herpes zoster) is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox ? the varicella-zoster virus. The first sign of shingles is often burning or tingling pain, or sometimes numbness or itch, in one particular location on only one side of the body. After several days or a week, a rash of fluid-filled blisters, similar to chickenpox, appears in one area on one side of the body. Shingles pain can be mild or intense.

Wikipedia:63 Herpes zoster (or simply zoster), commonly known as shingles and also known as zona, is a viral disease... more...

Aliases & Classifications for Herpes Zoster

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8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

herpes zoster 8 43 10 44
shingles 8 43 33
herpes zoster disease 60
herpes zona 8


External Ids:

Disease Ontology8 DOID:8536
MeSH34 D006562
NCIt39 C71079
ICD9CM27 053

Related Diseases for Herpes Zoster

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Herpes Zoster via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1geniculate herpes zoster30.9GPHN
2retinitis30.9POLE, GYPC
3lupus erythematosus30.8CD79A
4chickenpox30.8TKT, DPYD, GYPC
5arthritis30.8FCGR3A, HP, CCR5
6rheumatoid arthritis30.8CCR5, GYPC, CD79A, HP, TKT, FCGR3A
7encephalitis30.7CCR5, GYPC, CD9
8leukemia30.7IFNA2, CD9, CD79A, HP, GPHN, TKT
9herpes simplex30.6GYPC, POLE, DPYD, CD79A, TKT, TMPO
10myeloma30.5IFNA2, CD9, CD79A
11multiple sclerosis30.5TMPO, CCR5
12meningitis30.5CD79A
13vasculitis30.5CD79A, IFNA2
14psoriasis30.2FCGR3A
15purpura30.2CD79A
16dermatitis30.2CD79A
17measles30.2CD79A
18acute leukemia30.2TKT, CD8A
19tuberculosis30.2CD9, CD79A, HP, TKT
20sarcoidosis30.0CCR5
21vitiligo30.0CD8A
22sarcoma30.0TKT
23acquired immunodeficiency syndrome30.0CCR5, POLE
24inflammatory bowel disease30.0CD79A
25hepatitis30.0IFNA2, POLE, HP, TKT, TMPO
26asthma30.0TKT, CD79A, CCR5
27hepatitis c30.0HP, IFNA2, CCR5
28ophthalmoplegia10.6
29hemiplegia10.6
30systemic lupus erythematosus10.5
31cerebritis10.5
32granuloma annulare10.5
33keratitis10.5
34neuritis10.5
35neuropathy10.5
36myelitis10.5
37granulomatous angiitis10.5
38myositis10.4
39choroiditis10.4
40meningoencephalitis10.4
41colonic pseudo-obstruction10.4
42horner's syndrome10.4
43multiple myeloma10.4
44uveitis10.4
45postherpetic neuralgia10.4
46central retinal artery occlusion10.3
47bell's palsy10.3
48neurogenic bladder10.3
49cranial nerve palsy10.3
50laryngitis10.3

Graphical network of the top 20 diseases related to Herpes Zoster:



Diseases related to herpes zoster

Clinical Features for Herpes Zoster

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 7)
  • headache
  • fever
  • malaise
  • itching
  • burning pain
  • paresthesia
  • rash which is followed by blisters

Drugs & Therapeutics for Herpes Zoster

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Herpes Zoster

Drug clinical trials:

Search ClinicalTrials for Herpes Zoster

Search NIH Clinical Center for Herpes Zoster

Search CenterWatch for Herpes Zoster

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Herpes Zoster

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Anatomical Context for Herpes Zoster

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Herpes Zoster:

32
Skin, Colon, T cells, Kidney, Bone, Eye, Testes, Bone marrow, Myeloid, B cells, Liver, Monocytes, Heart, Spinal cord, Retina, Brain

FMA organs/tissues related to Herpes Zoster:

14
Nerve fiber

Animal Models for Herpes Zoster or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Herpes Zoster:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.3TMPO, MS4A1, HP, CD8A, CD79A, CD9

Publications for Herpes Zoster

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Sources:
50PubMed
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Articles related to Herpes Zoster:

(show top 50)    (show all 1048)
idTitleAuthorsYear
1
Co-reactivation of varicella zoster virus and herpes simplex virus with disseminated cutaneous lesions in a lymphoma patient. (23974591)
2013
2
Association between recent herpes zoster but not herpes simplex infection and subsequent risk of malignancy in women: a retrospective cohort studyA -A CORRIGENDUM. (24040842)
2013
3
Herpes simplex and herpes zoster eye disease: presentation and management at a city hospital for the underserved in the United States. (23771014)
2013
4
Zostavax : a subcutaneous vaccine for the prevention of herpes zoster. (23984934)
2013
5
Cost-effectiveness of vaccination of the elderly against herpes zoster in The Netherlands. (23306360)
2013
6
Herpes zoster ophthalmicus in a healthy child. (23697452)
2013
7
Bilateral disseminated herpes zoster in an immunocompetent host. (23473283)
2013
8
Unilateral herpes zoster ophthalmicus results in bilateral corneal nerve alteration: an in vivo confocal microscopy study. (22999636)
2013
9
Vaccination against herpes zoster and postherpetic neuralgia in France: a cost-effectiveness analysis. (23537397)
2013
10
Herpes zoster and subsequent risk of cancer: a population-based study. (23545577)
2013
11
Herpes zoster vaccination in SLE: a pilot study of immunogenicity. (24037550)
2013
12
Risk of herpes/herpes zoster during anti-tumor necrosis factor therapy in patients with rheumatoid arthritis. Systematic review and meta-analysis. (23932722)
2013
13
Dystrophic xanthomatization as a type of Wolf's isotopic response: eruptive xanthomata at a herpes zoster site. (23317991)
2013
14
Orbital apex syndrome in herpes zoster ophthalmicus. (22830066)
2012
15
Risk of herpes zoster in CKD: a matched-cohort study based on administrative data. (22575666)
2012
16
Herpes zoster-induced abdominal wall paresis: neurophysiological examination in this unusual complication. (21911226)
2012
17
Vaccines for preventing herpes zoster in older adults. (23076951)
2012
18
Measuring the burden of herpes zoster and post herpetic neuralgia within primary care in rural Crete, Greece. (22145678)
2011
19
Perceptions of herpes zoster and attitudes towards zoster vaccination among 50-65-year-old Danes. (22142574)
2011
20
Herpes zoster and multiple sclerosis. (21653525)
2011
21
Herpes zoster ophthalmicus and HIV seropositivity in South-south Nigeria. (20642081)
2010
22
Importance of vaccination against herpes zoster. (20207984)
2010
23
Does herpes zoster ophthalmicus increase the risk of stroke? (20200347)
2010
24
A prospective study of the herpes zoster severity of illness. (20842005)
2010
25
Herpes zoster: are selective nerve root injections the treatment or the cause? (20309386)
2010
26
Herpes zoster and vaccination: a clinical review. (20410546)
2010
27
Ophthalmoplegia secondary to herpes zoster ophthalmicus. (22798518)
2010
28
A case of recurrent herpes zoster leg paresis without rash. (20345198)
2010
29
Herpes zoster laryngitis with intractable hiccups. (19264432)
2009
30
Meningoencephalitis-complicating herpes zoster ophthalmicus infection. (19670385)
2009
31
Type I Boston keratoprosthesis with cataract extraction and intraocular lens placement for visual rehabilitation of herpes zoster ophthalmicus: the "KPro Triple". (19098045)
2009
32
Clinical challenges and images in GI. Colonic pseudo-obstruction as a rare complication of herpes zoster. (18619453)
2008
33
Evaluation of the cost-effectiveness in the United States of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. (17980938)
2007
34
Herpes Zoster Ophthalmicus in HIV/AIDS. (17491842)
2003
35
Corneal epithelial keratitis in herpes zoster ophthalmicus: "delayed" and "sine herpete". A non-contact photomicrographic in vivo study in the human cornea. (12219995)
2002
36
Uveitis in Herpes zoster ophthalmicus. (11778812)
2001
37
Does treatment of acute herpes zoster prevent or shorten postherpetic neuralgia? (10735485)
2000
38
Valaciclovir in herpes zoster ophthalmicus: new indication. An empty clinical assessment file. (10558445)
1999
39
Herpes zoster and postherpetic neuralgia. Optimal treatment. (9061266)
1997
40
Herpes zoster ophthalmicus and the mesencephalic nucleus. A neuropathological study. (3489349)
1986
41
Unilateral inferior altitudinal hemianopsia, Argyll Robertson pupil and dendritic keratitis in a young patient with herpes zoster. (6975913)
1981
42
A case of facial diplegi following herpes zoster ophthalmicus. (6967406)
1980
43
Herpes zoster ophthalmicus with contralateral hemiplegia. (303089)
1977
44
Necrotizing retinopathy with herpes zoster ophthalmicus: a light and electron microscopical study. (180930)
1976
45
Systemic lupus erythematosus, miliary tuberculosis, and bilateral herpes zoster occurring in a Chinese woman. (5120186)
1971
46
HERPES ZOSTER OPHTHALMICUS IN AN 8-YEAR-OLD CHILD. (14186864)
1963
47
Treatment of herpes zoster ophthalmicus with cortisone or corticotropin. (13217545)
1955
48
Pathogenesis of cranial nerve lesions, notably ophthalmoplegias, complicating herpes zoster ophthalmicus. (18881892)
1948
49
Diphtheria antitoxin and other foreign proteins in the treatment of herpes zoster ophthalmicus. (20285384)
1947
50
Herpes zoster ophthalmicus with varied complication. (21027009)
1946

Genetic Variations for Herpes Zoster

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Expression for genes affiliated with Herpes Zoster

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Herpes Zoster

Search GEO for disease gene expression data for Herpes Zoster.

Pathways for genes affiliated with Herpes Zoster

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Sources:
29KEGG
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Pathways related to Herpes Zoster according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0MS4A1, CD8A, CD9

Compounds for genes affiliated with Herpes Zoster

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Herpes Zoster according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6CD79A
2bv-arau4410.6TKT, DPYD
3bvdu4410.6TKT, DPYD
4idurd4410.6TKT, DPYD
5mizoribine4410.5CD79A, IFNA2
6Ibritumomab1110.5FCGR3A, MS4A1
7tositumomab49 1111.5FCGR3A, MS4A1
8cidofovir44 1111.5TKT, IFNA2
9vidarabine44 1111.5TKT, IFNA2
10gamma globulin4410.5IFNA2, CD79A
115-deoxy-5-fluorouridine4410.5IFNA2, DPYD, TKT
12foscarnet44 1111.4TKT, CD9
13fudr4410.4IFNA2, DPYD, TKT
14con a4410.4HP, CD79A, IFNA2
15ivig4410.4FCGR3A, CD79A, CCR5
16didanosine44 1111.4TKT, CD9, IFNA2
17ribavirin44 49 1112.4CCR5, IFNA2, HP
18adefovir4410.4IFNA2, TKT
19acyclovir44 1111.4TKT, CD9, IFNA2
20diethyl dithiocarbamate4410.4TKT, CD9, IFNA2
21pyrimidine nucleoside4410.4TKT, DPYD
22vinblastine44 49 1112.4TUBA1A, IFNA2, TKT
23leucovorin44 49 1112.4IFNA2, DPYD, TKT, TMPO
24orotic acid44 11 2412.4DPYD, TKT
25neopterin4410.3IFNA2, CD9, CD79A, HP
26mannose4410.3CCR5, CD9, CD79A, FCGR3A
27polyethylene glycol4410.3IFNA2, CD9, CD79A, HP
28methotrexate44 49 1112.3DPYD, CD79A, TKT, FCGR3A
295fluorouracil4410.3IFNA2, DPYD, TKT, TMPO
30vitamin-e4410.2HP, IFNA2, CCR5
31rituximab44 49 1112.2MS4A1, FCGR3A, HP, CD79A, IFNA2
32methionine4410.2TMPO, HP, IFNA2, CCR5
33purine44 2411.2CD9, DPYD, IFNA2
34tomudex4410.2TKT, DPYD
35nucleoside4410.2CCR5, IFNA2, DPYD, HP, TKT
36zidovudine44 1111.2CCR5, IFNA2, CD9, TKT, TMPO
37benzidine4410.2TKT, HP
38mitomycin c4410.1TKT, DPYD, IFNA2
39azathioprine44 49 2 1113.1IFNA2, DPYD, CD79A
40paraffin4410.1DPYD, CD9, CD79A, TKT, MS4A1
41ascorbic acid44 2411.1IFNA2, CD9, CD79A, HP, TKT
42iron44 2411.1IFNA2, NDUFB8, DPYD, CD9, HP
43polysaccharide4410.1CCR5, CD9, CD79A, HP
44thymidine44 2411.1IFNA2, GYPC, DPYD, CD9, TKT
45thymidylate449.9IFNA2, DPYD, TKT
46alanine449.9CCR5, IFNA2, GYPC, CD9, CD79A, HP
47tuberculin449.9HP, CD79A
48cysteine449.8CCR5, IFNA2, DPYD, CD9, CD79A, HP
49tyrosine449.5CCR5, IFNA2, GYPC, DPYD, CD9, CD8A

GO Terms for genes affiliated with Herpes Zoster

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16Gene Ontology
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Cellular components related to Herpes Zoster according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6MS4A1, FCGR3A, CD8A, CD79A, CD9, CCR5

Biological processes related to Herpes Zoster according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069559.9MS4A1, FCGR3A, CD8A, CCR5

Products for genes affiliated with Herpes Zoster

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Herpes Zoster

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet