MCID: HRP004
MIFTS: 57

Herpes Zoster malady

Infectious diseases, Neuronal diseases categories

Summaries for Herpes Zoster

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Sources:
9Disease Ontology, 35MedlinePlus, 45NINDS, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Shingles is a disease caused by the varicella-zoster virus - the same virus that causes chickenpox. after you have chickenpox, the virus stays in your body. it may not cause problems for many years. as you get older, the virus may reappear as shingles. although it is most common in people over age 50, anyone who has had chickenpox is at risk. you can't catch shingles from someone who has it. however, if you have a shingles rash, you can pass the virus to someone who has never had chickenpox. this would usually be a child, who could get chickenpox instead of shingles. the virus spreads through direct contact with the rash, and cannot spread through the air. early signs of shingles include burning or shooting pain and tingling or itching, usually on one side of the body or face. the pain can be mild to severe. rashes or blisters appear anywhere from one to 14 days later. if shingles appears on your face, it may affect your vision or hearing. the pain of shingles may last for weeks, months, or even years after the blisters have healed. there is no cure for shingles. early treatment with medicines that fight the virus may help. these medicines may also help prevent lingering pain. a vaccine may prevent shingles or lessen its effects. the vaccine is recommended for people 60 or over. in some cases doctors may give it to people ages 50 to 59. nih: national institute of allergy and infectious diseases

MalaCards: Herpes Zoster, also known as shingles, is related to chickenpox and rheumatoid arthritis, and has symptoms including headache, malaise and rash which is followed by blisters. An important gene associated with Herpes Zoster is FCGR3A (Fc fragment of IgG, low affinity IIIa, receptor (CD16a)). The drugs capsaicin and famciclovir and the compounds bevacizumab and trastuzumab have been mentioned in the context of this disorder. Affiliated tissues include nerve fiber, skin and colon.

Disease Ontology:9 A viral infectious disease that results in infection located in nerve fiber, has material basis in human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. the virus is transmitted by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. the infection has symptom rash which is followed by blisters, has symptom headache, has symptom fever, has symptom malaise, has symptom itching, has symptom burning pain, and has symptom paresthesia.

NINDS:45 Shingles (herpes zoster) is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox ? the varicella-zoster virus. The first sign of shingles is often burning or tingling pain, or sometimes numbness or itch, in one particular location on only one side of the body. After several days or a week, a rash of fluid-filled blisters, similar to chickenpox, appears in one area on one side of the body. Shingles pain can be mild or intense.

Wikipedia:66 Herpes zoster (or simply zoster), commonly known as shingles and also known as zona, is a viral disease... more...

Aliases & Classifications for Herpes Zoster

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Sources:
9Disease Ontology, 45NINDS, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

herpes zoster 9 45 11 46
shingles 9 45 35
herpes zoster disease 63
herpes zona 9


External Ids:

Disease Ontology9 DOID:8536
ICD9CM28 053
MeSH36 D006562
NCIt41 C71079

Related Diseases for Herpes Zoster

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Herpes Zoster:



Diseases related to herpes zoster

Symptoms for Herpes Zoster

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Sources:
9Disease Ontology
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Symptoms:

9 (show all 7)
  • headache
  • malaise
  • rash which is followed by blisters
  • itching
  • burning pain
  • paresthesia
  • fever

Drugs & Therapeutics for Herpes Zoster

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Herpes Zoster

Drug clinical trials:

Search ClinicalTrials for Herpes Zoster

Search NIH Clinical Center for Herpes Zoster

Search CenterWatch for Herpes Zoster

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Herpes Zoster

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Anatomical Context for Herpes Zoster

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Herpes Zoster:

34
Skin, Colon, Kidney, T cells, Eye, Testes, Bone, Myeloid, Bone marrow, Monocytes, B cells, Heart, Retina, Spinal cord, Brain, Liver

FMA organs/tissues related to Herpes Zoster:

15
Nerve fiber

Animal Models for Herpes Zoster or affiliated genes

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Publications for Herpes Zoster

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53PubMed
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Articles related to Herpes Zoster:

(show top 50)    (show all 1013)
idTitleAuthorsYear
1
Acute respiratory distress syndrome due to varicella zoster virus pneumonitis in an immunocompromised patient with herpes zoster. (24330179)
2013
2
Alopecia areata associated with Herpes zoster. (23682830)
2013
3
Increased Density of Cutaneous Nerve Fibres in the Affected Dermatomes After Herpes Zoster Therapy. (23995395)
2013
4
Effects of highly active antiretroviral therapy and its adherence on herpes zoster incidence: a longitudinal cohort study. (24373482)
2013
5
Varicella zoster virus-specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medications. (23413415)
2013
6
Safety, humoral and cell-mediated immune responses to herpes zoster vaccine in subjects with diabetes mellitus. (23603250)
2013
7
An inverse correlation of VZV skin-test reaction, but not antibody, with severity of herpes zoster skin symptoms and zoster-associated pain. (23183011)
2013
8
Multiple actinic keratoses and squamous carcinomas at the site of prior herpes zoster. (23253078)
2013
9
Cutaneous herpes zoster. (23901015)
2013
10
Effect of pharmacist intervention on herpes zoster vaccination in community pharmacies. (23636155)
2013
11
Orbital apex syndrome in herpes zoster ophthalmicus. (22830066)
2012
12
Does methotrexate increase the risk of varicella or herpes zoster infection in patients with rheumatoid arthritis? A systematic literature review. (23044005)
2012
13
Herpes zoster in patients with drug-induced hypersensitivity syndrome/DRESS. (22307980)
2012
14
Prescription of antiviral therapy after herpes zoster in general practice: who receives therapy? (23211260)
2012
15
Granulomatous reaction at the site of healed herpes zoster in a patient with adult T-cell leukemia/lymphoma. (21950342)
2012
16
Managing the care of patients with herpes zoster ophthalmicus. (21739797)
2011
17
Increased risk of a cancer diagnosis after herpes zoster ophthalmicus: a nationwide population-based study. (21232800)
2011
18
Penile herpes zoster: an unusual location for a common disease. (22218522)
2011
19
Management of herpes zoster and post-herpetic neuralgia now and in the future. (20510264)
2010
20
Epidemiology and economic burden of herpes zoster and post-herpetic neuralgia in Italy: a retrospective, population-based study. (20682044)
2010
21
Alteration in antibody-mediated immunity in patients with rituximab-combined chemotherapy and incidence of herpes zoster]. (20087040)
2010
22
Unusual formation of keloids after each episode of recurrent herpes zoster in an HIV positive patient. (21938132)
2009
23
Eruption severity and characteristics in herpes zoster ophthalmicus: correlation with visual outcome, ocular complications, and postherpetic neuralgia. (19416378)
2009
24
Disseminated herpes zoster mimicking rheumatoid vasculitis in a rheumatoid arthritis patient on etanercept. (19648728)
2009
25
Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete. (18245272)
2008
26
Antiviral therapy for Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults. (18843734)
2008
27
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. (15930418)
2005
28
Herpes zoster and postherpetic neuralgia: prevention and management. (16190505)
2005
29
Herpes zoster ophthalmicus in an otherwise-healthy child. (16414532)
2005
30
Neuraxial and sympathetic blocks in herpes zoster and postherpetic neuralgia: an appraisal of current evidence. (15372391)
2004
31
Reduction of postherpetic neuralgia in herpes zoster. (11907852)
2001
32
Postherpetic neuralgia: impact of famciclovir, age, rash severity, and acute pain in herpes zoster patients. (9852980)
1998
33
Colonic pseudo-obstruction: a complication of herpes zoster. (7942751)
1994
34
Granuloma annulare arising after herpes zoster. (1399211)
1992
35
Readers comment on "Herpes zoster ophthalmicus". (1455299)
1992
36
Clinical profile of herpes zoster ophthalmicus. (1748774)
1991
37
Caring for patients with herpes zoster ophthalmicus. (2784213)
1989
38
Antiviral treatment in chickenpox and herpes zoster. (3339143)
1988
39
Herpes zoster of second and third segments causing ipsilateral Horner's syndrome. (3111588)
1987
40
Herpes zoster ophthalmicus with delayed cerebral infarction and meningoencephalitis. (3311326)
1987
41
Herpes zoster of second and third segments causing ipsilateral Horner's syndrome. (3115408)
1987
42
Herpes zoster ophthalmicus and delayed ipsilateral intracerebral hemorrhage. (3496558)
1987
43
Herpes zoster ophthalmicus and delayed contralateral hemiparesis caused by cerebral angiitis: diagnosis and management approaches. (6606387)
1983
44
Herpes zoster ophthalmicus. (312096)
1979
45
Herpes zoster ophthalmicus with contralateral hemiplegia. (303089)
1977
46
Temporal artery biopsy in herpes zoster ophthalmicus with delayed arteritis. (1086062)
1976
47
PSEUDOMELANOMA OF THE IRIS AFTER HERPES ZOSTER OPHTHALMICUS. (14129246)
1964
48
Herpes zoster ophthalmicus; report of a case in a three and one-half-year-old child. (13595053)
1958
49
Successful treatment of herpes zoster ophthalmicus with antihistaminic therapy. (13294985)
1956
50
Herpes zoster with a varicelliform eruption and parotitis in chronic leukemia. (14794487)
1951

Variations for Herpes Zoster

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Expression for genes affiliated with Herpes Zoster

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Herpes Zoster

Search GEO for disease gene expression data for Herpes Zoster.

Pathways for genes affiliated with Herpes Zoster

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Compounds for genes affiliated with Herpes Zoster

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Sources:
52PharmGKB, 12DrugBank, 46Novoseek, 25HMDB, 62Tocris Bioscience
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Compounds related to Herpes Zoster according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1bevacizumab52 1210.8DPYD, FCGR3A
2trastuzumab46 52 1211.8TKT, FCGR3A
3bv-arau469.7TKT, DPYD
4bvdu469.7DPYD, TKT
5idurd469.7TKT, DPYD
65-deoxy-5-fluorouridine469.7DPYD, TKT
7pyrimidine nucleoside469.7TKT, DPYD
8orotic acid46 25 1211.7TKT, DPYD
9tomudex469.7DPYD, TKT
10asparagine469.7GYPC, FCGR3A
11zidovudine46 52 1211.6TKT, TMPO
12deoxyuridine46 2510.6TKT, DPYD
13fudr469.6TKT, DPYD
14thymine46 2510.6DPYD, TKT
15deoxycytidine46 2510.6DPYD, TKT
16fmlp469.5TKT, FCGR3A
17pyrimidine46 2510.5DPYD, TKT
18uridine46 25 1211.5TKT, DPYD
19mitomycin c469.4DPYD, TKT
20molybdenum46 2510.3DPYD, GPHN
21nucleoside469.3TKT, DPYD
22cetuximab46 52 1211.3TKT, DPYD, FCGR3A
23xanthine46 2510.3GPHN, DPYD
24leucovorin46 52 1211.3TKT, DPYD, TMPO
25methotrexate52 46 1211.3TKT, DPYD, FCGR3A
26herbimycin a46 6210.2TKT, FCGR3A
27thymidylate469.2TKT, DPYD
285fluorouracil469.2TMPO, DPYD, TKT
29glyceraldehyde 3-phosphate469.1TKT, DPYD, GYPC
30thymidine46 2510.1TKT, DPYD, GYPC
31tyrosine468.3TKT, DPYD, GYPC, TMPO, FCGR3A

GO Terms for genes affiliated with Herpes Zoster

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Products for genes affiliated with Herpes Zoster

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Herpes Zoster

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet