MCID: HRP004
MIFTS: 61

Herpes Zoster malady

Summaries for Herpes Zoster

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8Disease Ontology, 33MedlinePlus, 3CDC, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Shingles is a disease caused by the varicella-zoster virus - the same virus that causes chickenpox. after you have chickenpox, the virus stays in your body. it may not cause problems for many years. as you get older, the virus may reappear as shingles. although it is most common in people over age 50, anyone who has had chickenpox is at risk. unlike chickenpox, you can't catch shingles from someone who has it. early signs of shingles include burning or shooting pain and tingling or itching, usually on one side of the body or face. the pain can be mild to severe. rashes or blisters appear anywhere from one to 14 days later. if shingles appears on your face, it may affect your vision or hearing. the pain of shingles may last for weeks, months, or even years after the blisters have healed. there is no cure for shingles. early treatment with medicines that fight the virus may help. these medicines may also help prevent lingering pain. a vaccine may prevent shingles or lessen its effects. the vaccine is recommended for people 60 or over. in some cases doctors may give it to people ages 50 to 59. nih: national institute of allergy and infectious diseases

MalaCards: Herpes Zoster, also known as shingles, is related to geniculate herpes zoster and retinitis, and has symptoms including headache, malaise and paresthesia. An important gene associated with Herpes Zoster is FCGR3A (Fc fragment of IgG, low affinity IIIa, receptor (CD16a)), and among its related pathways is Hematopoietic cell lineage. The drugs capsaicin and famciclovir and the compounds estrogen and bv-arau have been mentioned in the context of this disorder. Affiliated tissues include nerve fiber, skin and colon, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in infection located in nerve fiber, has material basis in human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. the virus is transmitted by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. the infection has symptom rash which is followed by blisters, has symptom headache, has symptom fever, has symptom malaise, has symptom itching, has symptom burning pain, and has symptom paresthesia.

CDC:3 Shingles, also known as zoster or herpes zoster, is a painful skin rash caused by the varicella zoster virus, the same virus that causes chickenpox. Nearly 1 out of every 3 people in the United States will develop shingles. Anyone who has recovered from chickenpox may develop shingles; even children can get shingles. However, the risk of getting the disease increases as a person gets older. About half of all cases occur among men and women who are 60 years old or older... more

NINDS:43 Shingles (herpes zoster) is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox ? the varicella-zoster virus. The first sign of shingles is often burning or tingling pain, or sometimes numbness or itch, in one particular location on only one side of the body. After several days or a week, a rash of fluid-filled blisters, similar to chickenpox, appears in one area on one side of the body. Shingles pain can be mild or intense.

Wikipedia:63 Herpes zoster (or simply zoster), commonly known as shingles and also known as zona, is a viral disease... more...

Aliases & Classifications for Herpes Zoster

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8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

herpes zoster 8 43 10 44
shingles 8 43 33
herpes zoster disease 60
herpes zona 8


External Ids:

Disease Ontology8 DOID:8536
MeSH34 D006562
NCIt39 C71079
ICD9CM27 053

Related Diseases for Herpes Zoster

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Herpes Zoster via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1geniculate herpes zoster30.9GPHN
2retinitis30.9POLE, GYPC
3lupus erythematosus30.8CD79A
4chickenpox30.8TKT, DPYD, GYPC
5arthritis30.8FCGR3A, HP, CCR5
6rheumatoid arthritis30.8CCR5, GYPC, CD79A, HP, TKT, FCGR3A
7encephalitis30.7CCR5, GYPC, CD9
8leukemia30.7IFNA2, CD9, CD79A, HP, GPHN, TKT
9herpes simplex30.6GYPC, POLE, DPYD, CD79A, TKT, TMPO
10myeloma30.5IFNA2, CD9, CD79A
11multiple sclerosis30.5TMPO, CCR5
12meningitis30.5CD79A
13vasculitis30.5CD79A, IFNA2
14psoriasis30.2FCGR3A
15purpura30.2CD79A
16dermatitis30.2CD79A
17measles30.2CD79A
18acute leukemia30.2TKT, CD8A
19tuberculosis30.2CD9, CD79A, HP, TKT
20sarcoidosis30.0CCR5
21vitiligo30.0CD8A
22sarcoma30.0TKT
23acquired immunodeficiency syndrome30.0CCR5, POLE
24inflammatory bowel disease30.0CD79A
25hepatitis30.0IFNA2, POLE, HP, TKT, TMPO
26asthma30.0TKT, CD79A, CCR5
27hepatitis c30.0HP, IFNA2, CCR5
28ophthalmoplegia10.6
29hemiplegia10.6
30systemic lupus erythematosus10.5
31cerebritis10.5
32granuloma annulare10.5
33keratitis10.5
34neuritis10.5
35neuropathy10.5
36myelitis10.5
37granulomatous angiitis10.5
38myositis10.4
39choroiditis10.4
40meningoencephalitis10.4
41colonic pseudo-obstruction10.4
42horner's syndrome10.4
43multiple myeloma10.4
44uveitis10.4
45postherpetic neuralgia10.4
46central retinal artery occlusion10.3
47bell's palsy10.3
48neurogenic bladder10.3
49cranial nerve palsy10.3
50laryngitis10.3

Graphical network of the top 20 diseases related to Herpes Zoster:



Diseases related to herpes zoster

Clinical Features for Herpes Zoster

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8Disease Ontology
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Symptoms:

8 (show all 7)
  • headache
  • malaise
  • paresthesia
  • rash which is followed by blisters
  • itching
  • burning pain
  • fever

Drugs & Therapeutics for Herpes Zoster

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Herpes Zoster

Drug clinical trials:

Search ClinicalTrials for Herpes Zoster

Search NIH Clinical Center for Herpes Zoster

Search CenterWatch for Herpes Zoster

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Herpes Zoster

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Anatomical Context for Herpes Zoster

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Herpes Zoster:

32
Skin, Colon, Kidney, T cells, Bone, Eye, Testes, Bone marrow, Myeloid, Monocytes, B cells, Retina, Heart, Brain, Spinal cord, Liver

FMA organs/tissues related to Herpes Zoster:

14
Nerve fiber

Animal Models for Herpes Zoster or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Herpes Zoster:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.3TMPO, MS4A1, HP, CD8A, CD79A, CD9

Publications for Herpes Zoster

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Sources:
50PubMed
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Articles related to Herpes Zoster:

(show top 50)    (show all 1048)
idTitleAuthorsYear
1
Herpes zoster ophthalmicus masked by hymenoptera stings. (23085675)
2014
2
Alopecia areata associated with Herpes zoster. (23682830)
2013
3
Herpes zoster: diagnostic, therapeutic, and preventive approaches. (24113666)
2013
4
Kyrieleis plaques in herpes zoster virus-associated acute retinal necrosis: a case report. (23743534)
2013
5
Herpes zoster in older adults. (23860452)
2013
6
Herpes zoster knowledge, prevalence, and vaccination rate by race. (23288280)
2013
7
Herpes zoster as a cause of viral meningitis in immunocompetent patients. (23307457)
2013
8
Herpes zoster in patients with drug-induced hypersensitivity syndrome/DRESS. (22307980)
2012
9
C8 myotome herpes zoster paresis. (22715438)
2012
10
Periorbital necrotising fasciitis following cutaneous herpes zoster. (21788161)
2012
11
Valomaciclovir versus valacyclovir for the treatment of acute herpes zoster in immunocompetent adults: a randomized, double-blind, active-controlled trial. (22711350)
2012
12
Herpes zoster: family history and psychological stress-case-control study. (22824229)
2012
13
Herpes zoster duplex bilateralis in an immunocompetent woman--is gender a risk factor? (23088662)
2012
14
Herpes zoster recurrences more frequent than previously reported. (21220354)
2011
15
T cell lymphoma with disseminated herpes zoster on presentation and subsequent recurrence leading to blindness--a case report. (21210119)
2011
16
Administration of Vitamin C in a Patient with Herpes Zoster - A case report -. (21716609)
2011
17
Ophthalmic herpes zoster infection in patients with rheumatoid arthritis who were treated with tocilizumab. (21285184)
2011
18
Herpes zoster laryngitis and Ramsay-Hunt syndrome in a patient with chronic renal failure. (22338244)
2011
19
Herpes zoster incidence in a multicenter cohort of solid organ transplant recipients. (20636480)
2011
20
Acupuncture for the treatment of severe acute pain in herpes zoster: results of a nested, open-label, randomized trial in the VZV Pain Study. (21639941)
2011
21
Magnetic resonance images of herpes zoster myelitis presenting with Brown-SAcquard syndrome. (20385921)
2010
22
Effect of a zoster vaccine on herpes zoster-related interference with functional status and health-related quality-of-life measures in older adults. (20863322)
2010
23
Evidence of increasing frequency of herpes zoster management in Australian general practice since the introduction of a varicella vaccine. (20955129)
2010
24
Do the health-care workers gain protection against herpes zoster infection? A 6-year population-based study in Taiwan. (20536652)
2010
25
Herpes zoster and postherpetic neuralgia. (20921245)
2010
26
Axillary mononeuropathy after herpes zoster infection mimicking subacromial impingement syndrome. (18806513)
2008
27
Sympathetic nerve blocks in mandibular herpes zoster and postherpetic neuralgia. (17501858)
2007
28
A novel vaccine (Zostavax) to prevent herpes zoster and postherpetic neuralgia. (17039651)
2006
29
Varicella zoster virus encephalitis in a previously healthy five-year-old child with herpes zoster ophthalmicus. (15876958)
2005
30
Can vaccinating older adults against varicella zoster virus prevent herpes zoster and postherpetic neuralgia? (16932487)
2005
31
A case of complete ophthalmoplegia in herpes zoster ophthalmicus. (16491822)
2005
32
Herpes zoster and postherpetic neuralgia: incidence and risk indicators using a general practice research database. (12356697)
2002
33
Extraocular muscle and facial paresis in herpes zoster ophthalmicus. (11759776)
2001
34
Allodynia and pinprick hypesthesia in acute herpes zoster, and the development of postherpetic neuralgia. (10946169)
2000
35
Herpes zoster ophthalmicus in patients with human immunodeficiency virus infection. (9512144)
1998
36
The synthesis and immunogenicity of varicella-zoster virus glycoprotein E and immediate-early protein (IE62) expressed in recombinant herpes simplex virus-1. (9037375)
1997
37
Influence of oral acyclovir on ocular complications of herpes zoster ophthalmicus. (8013722)
1994
38
Clinical aspects of chickenpox and herpes zoster. (8063022)
1994
39
Detection of varicella-zoster virus DNA using the polymerase chain reaction in an immunocompromised patient with transverse myelitis secondary to herpes zoster. (7721287)
1993
40
Granuloma annulare and disseminated herpes zoster. (1737692)
1992
41
Readers comment on "Herpes zoster ophthalmicus". (1333645)
1992
42
Gadolinium-enhanced magnetic resonance imaging of the facial nerve in herpes zoster oticus and Bell's palsy: clinical implications. (1882962)
1991
43
Herpes zoster ophthalmicus and AIDS. (3500742)
1987
44
Neurogenic bladder from occult herpes zoster. (3774661)
1986
45
Herpes zoster ophthalmicus and acquired immune deficiency syndrome. (6611148)
1984
46
Herpes zoster ophthalmicus and delayed contralateral hemiparesis caused by cerebral angiitis: diagnosis and management approaches. (6606387)
1983
47
Ipsilateral deafness and herpes zoster ophthalmicus. (6600599)
1983
48
Herpes zoster ophthalmicus and delayed contralateral hemiparesis. Relationship of the syndrome to central nervous system granulomatous angiitis. (4546095)
1974
49
Epidemic herpes zoster ophthalmicus. Report of a case treated with aureomycin. (14789945)
1950
50
Herpes Zoster Ophthalmicus: Report of Cases and a Review of the Literature. (16693295)
1942

Genetic Variations for Herpes Zoster

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Expression for genes affiliated with Herpes Zoster

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Herpes Zoster

Search GEO for disease gene expression data for Herpes Zoster.

Pathways for genes affiliated with Herpes Zoster

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29KEGG
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Pathways related to Herpes Zoster according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0MS4A1, CD8A, CD9

Compounds for genes affiliated with Herpes Zoster

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Herpes Zoster according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6CD79A
2bv-arau4410.6TKT, DPYD
3bvdu4410.6TKT, DPYD
4idurd4410.6TKT, DPYD
5mizoribine4410.5CD79A, IFNA2
6Ibritumomab1110.5FCGR3A, MS4A1
7tositumomab49 1111.5FCGR3A, MS4A1
8cidofovir44 1111.5TKT, IFNA2
9vidarabine44 1111.5TKT, IFNA2
10gamma globulin4410.5IFNA2, CD79A
115-deoxy-5-fluorouridine4410.5IFNA2, DPYD, TKT
12foscarnet44 1111.4TKT, CD9
13fudr4410.4IFNA2, DPYD, TKT
14con a4410.4HP, CD79A, IFNA2
15ivig4410.4FCGR3A, CD79A, CCR5
16didanosine44 1111.4TKT, CD9, IFNA2
17ribavirin44 49 1112.4CCR5, IFNA2, HP
18adefovir4410.4IFNA2, TKT
19acyclovir44 1111.4TKT, CD9, IFNA2
20diethyl dithiocarbamate4410.4TKT, CD9, IFNA2
21pyrimidine nucleoside4410.4TKT, DPYD
22vinblastine44 49 1112.4TUBA1A, IFNA2, TKT
23leucovorin44 49 1112.4IFNA2, DPYD, TKT, TMPO
24orotic acid44 11 2412.4DPYD, TKT
25neopterin4410.3IFNA2, CD9, CD79A, HP
26mannose4410.3CCR5, CD9, CD79A, FCGR3A
27polyethylene glycol4410.3IFNA2, CD9, CD79A, HP
28methotrexate44 49 1112.3DPYD, CD79A, TKT, FCGR3A
295fluorouracil4410.3IFNA2, DPYD, TKT, TMPO
30vitamin-e4410.2HP, IFNA2, CCR5
31rituximab44 49 1112.2MS4A1, FCGR3A, HP, CD79A, IFNA2
32methionine4410.2TMPO, HP, IFNA2, CCR5
33purine44 2411.2CD9, DPYD, IFNA2
34tomudex4410.2TKT, DPYD
35nucleoside4410.2CCR5, IFNA2, DPYD, HP, TKT
36zidovudine44 1111.2CCR5, IFNA2, CD9, TKT, TMPO
37benzidine4410.2TKT, HP
38mitomycin c4410.1TKT, DPYD, IFNA2
39azathioprine44 49 2 1113.1IFNA2, DPYD, CD79A
40paraffin4410.1DPYD, CD9, CD79A, TKT, MS4A1
41ascorbic acid44 2411.1IFNA2, CD9, CD79A, HP, TKT
42iron44 2411.1IFNA2, NDUFB8, DPYD, CD9, HP
43polysaccharide4410.1CCR5, CD9, CD79A, HP
44thymidine44 2411.1IFNA2, GYPC, DPYD, CD9, TKT
45thymidylate449.9IFNA2, DPYD, TKT
46alanine449.9CCR5, IFNA2, GYPC, CD9, CD79A, HP
47tuberculin449.9HP, CD79A
48cysteine449.8CCR5, IFNA2, DPYD, CD9, CD79A, HP
49tyrosine449.5CCR5, IFNA2, GYPC, DPYD, CD9, CD8A

GO Terms for genes affiliated with Herpes Zoster

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16Gene Ontology
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Cellular components related to Herpes Zoster according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6MS4A1, FCGR3A, CD8A, CD79A, CD9, CCR5

Biological processes related to Herpes Zoster according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069559.9MS4A1, FCGR3A, CD8A, CCR5

Products for genes affiliated with Herpes Zoster

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Herpes Zoster

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet