MCID: HRP004
MIFTS: 60

Herpes Zoster malady

Summaries for Herpes Zoster

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Shingles is a disease caused by the varicella-zoster virus - the same virus that causes chickenpox. after you have chickenpox, the virus stays in your body. it may not cause problems for many years. as you get older, the virus may reappear as shingles. although it is most common in people over age 50, anyone who has had chickenpox is at risk. unlike chickenpox, you can't catch shingles from someone who has it. early signs of shingles include burning or shooting pain and tingling or itching, usually on one side of the body or face. the pain can be mild to severe. rashes or blisters appear anywhere from one to 14 days later. if shingles appears on your face, it may affect your vision or hearing. the pain of shingles may last for weeks, months, or even years after the blisters have healed. there is no cure for shingles. early treatment with medicines that fight the virus may help. these medicines may also help prevent lingering pain. a vaccine may prevent shingles or lessen its effects. the vaccine is recommended for people 60 or over. in some cases doctors may give it to people ages 50 to 59. nih: national institute of allergy and infectious diseases

MalaCards: Herpes Zoster, also known as shingles, is related to geniculate herpes zoster and chickenpox, and has symptoms including fever, headache and malaise. An important gene associated with Herpes Zoster is FCGR3A (Fc fragment of IgG, low affinity IIIa, receptor (CD16a)), and among its related pathways is Hematopoietic cell lineage. The drugs capsaicin and famciclovir and the compounds estrogen and bv-arau have been mentioned in the context of this disorder. Affiliated tissues include nerve fiber, skin and liver, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in infection located in nerve fiber, has material basis in human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. the virus is transmitted by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. the infection has symptom rash which is followed by blisters, has symptom headache, has symptom fever, has symptom malaise, has symptom itching, has symptom burning pain, and has symptom paresthesia.

CDC:3 Shingles, also known as zoster or herpes zoster, is a painful skin rash caused by the varicella zoster virus, the same virus that causes chickenpox. Nearly 1 out of every 3 people in the United States will develop shingles. Anyone who has recovered from chickenpox may develop shingles; even children can get shingles. However, the risk of getting the disease increases as a person gets older. About half of all cases occur among men and women who are 60 years old or older... more

NINDS:44 Shingles (herpes zoster) is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox ? the varicella-zoster virus. The first sign of shingles is often burning or tingling pain, or sometimes numbness or itch, in one particular location on only one side of the body. After several days or a week, a rash of fluid-filled blisters, similar to chickenpox, appears in one area on one side of the body. Shingles pain can be mild or intense.

Wikipedia:64 Herpes zoster (or simply zoster), commonly known as shingles and also known as zona, is a viral disease... more...

Aliases & Classifications for Herpes Zoster

Sources:
8Disease Ontology, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM
See all sources

Aliases & Descriptions:

herpes zoster 8 44 10 45
shingles 8 44 34
herpes zoster disease 61
herpes zona 8


External Ids:

Disease Ontology8 DOID:8536
MeSH35 D006562
NCIt40 C71079
ICD9CM27 053

Related Diseases for Herpes Zoster

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Herpes Zoster:



Diseases related to herpes zoster

Clinical Features for Herpes Zoster

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 7)
  • fever
  • headache
  • malaise
  • paresthesia
  • rash which is followed by blisters
  • itching
  • burning pain

Drugs & Therapeutics for Herpes Zoster

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Herpes Zoster

Drug clinical trials:

Search ClinicalTrials for Herpes Zoster

Search NIH Clinical Center for Herpes Zoster

Search CenterWatch for Herpes Zoster

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Herpes Zoster

Anatomical Context for Herpes Zoster

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Herpes Zoster:

33
Skin, Liver, Spinal cord, Brain, Kidney, Bone marrow, Retina, Heart, Small intestine, Colon, Salivary gland, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Dorsal root ganglion, Trigeminal ganglion

FMA organs/tissues related to Herpes Zoster:

14
Nerve fiber

Animal Models for Herpes Zoster or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Herpes Zoster:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.3TMPO, MS4A1, HP, CD8A, CD79A, CD9

Publications for Herpes Zoster

Sources:
51PubMed
See all sources

Articles related to Herpes Zoster:

(show top 50)    (show all 1055)
idTitleAuthorsYear
1
Acute respiratory distress syndrome due to varicella zoster virus pneumonitis in an immunocompromised patient with herpes zoster. (24330179)
2013
2
Multiple actinic keratoses and squamous carcinomas at the site of prior herpes zoster. (23253078)
2013
3
Incidence and time trends of herpes zoster in rheumatoid arthritis: a population-based cohort study. (23281295)
2013
4
An unusual cause of shoulder pain; herpes zoster induced brachial plexopathy, a case report and review of the literature. (23887175)
2013
5
Concomitant administration of pneumococcal-23 and zoster vaccines provides adequate herpes zoster coverage. (23715069)
2013
6
Report of three cases of herpes zoster during treatment with natalizumab. (23419219)
2013
7
Ophthalmic manifestations of herpes zoster virus in patients with multiple myeloma following bone marrow transplantation. (23429015)
2013
8
Herpes zoster surveillance using electronic databases in the Valencian Community (Spain). (24094135)
2013
9
Estimating the age-specific duration of herpes zoster vaccine protection: a matter of model choice? (21964056)
2012
10
Internal carotid artery involvement in herpes zoster ophthalmicus. (22864142)
2012
11
A randomized controlled trial of a multifaceted integrated complementary-alternative therapy for chronic herpes zoster-related pain. (22502623)
2012
12
Herpes zoster pain, postherpetic neuralgia, and quality of life in the elderly. (21199312)
2011
13
Gangrenous herpes zoster with multidermatomal involvement in a patient after kidney transplantation. (21470498)
2011
14
Risk of herpes zoster among patients with psychiatric diseases: a population-based study. (20666877)
2011
15
Herpes zoster and meningitis due to reactivation of varicella vaccine virus in an immunocompetent child. (20844461)
2011
16
Occipital neuralgia following thoracic herpes zoster: case report. (22290683)
2011
17
Herpes zoster in Australia: evidence of increase in incidence in adults attributable to varicella immunization? (20727248)
2011
18
Population-based incidence of herpes zoster after introduction of a publicly funded varicella vaccination program. (21939721)
2011
19
Orbital apex syndrome associated with herpes zoster ophthalmicus. (22140305)
2011
20
Epidemiology and cost of herpes zoster and postherpetic neuralgia among patients treated in primary care centres in the Valencian community of Spain. (22044665)
2011
21
Filgrastim helps to heal herpes zoster faster: two case reports. (21528676)
2011
22
Syndrome of inappropriate secretion of antidiuretic hormone associated with localized herpes zoster ophthalmicus. (20878495)
2011
23
Complete unilateral ophthalmoplegia in herpes zoster ophthalmicus. (19952908)
2009
24
Herpes zoster - associated erythema multiforme. (21886721)
2009
25
Acute orbital myositis heralding herpes zoster ophthalmicus: report of a case. (18564828)
2008
26
Corticosteroids as adjuvant to antiviral treatment in Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults. (18646170)
2008
27
Herpes zoster ophthalmicus and syndrome of inappropriate antidiuretic hormone secretion. (18310984)
2008
28
Management strategies for herpes zoster and postherpetic neuralgia. (17488885)
2007
29
Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]. (12604384)
2003
30
An unusual presentation of herpes zoster ophthalmicus: orbital myositis preceding vesicular eruption. (12967827)
2003
31
Two cases of reactive hemophagocytic syndrome: a patient with adult-onset Still's disease and a patient with herpes zoster and autoimmune abnormalities. (24383780)
2001
32
Possible postherpetic neuralgia first occurring seven years after herpes zoster. (9633769)
1998
33
Optic neuroretinitis, a rare manifestation of herpes zoster ophthalmicus: a case report. (9282530)
1997
34
Dermatophytosis in healing herpes zoster lesions. (9252737)
1997
35
Colonic pseudo-obstruction: a complication of herpes zoster. (8733394)
1996
36
Effects of acyclovir on sensory axonal neuropathy, segmental motor paresis and postherpetic neuralgia in herpes zoster patients. (8864710)
1996
37
Granuloma annulare following herpes zoster. (1459773)
1992
38
Readers comment on "Herpes zoster ophthalmicus". (1455300)
1992
39
Antiviral treatment in chickenpox and herpes zoster. (3339143)
1988
40
Natural history of herpes zoster ophthalmicus: predictors of postherpetic neuralgia and ocular involvement. (3495293)
1987
41
Acute phthisis bulbi and external ophthalmoplegia in herpes zoster ophthalmicus. (3872092)
1985
42
Herpes zoster ophthalmicus in patients at risk for AIDS. (6608691)
1984
43
Preliminary results of oral BVDU treatment of herpes zoster ophthalmicus. (6979370)
1981
44
Cicatricial ectropion of the upper lid secondary to herpes zoster ophthalmicus. (6973306)
1981
45
Herpes zoster and paralytic ileus: a case report. (578122)
1977
46
Granulomatous angiitis of the nervous system in cases of herpes zoster and lymphosarcoma. (4552715)
1972
47
EPICANTHOID SECONDARY TO HERPES ZOSTER OPHTHALMICUS. (14167202)
1964
48
Meningoencephalitis complicating herpes zoster ophthalmicus after treatment by vaccination. (20999849)
1946
49
Herpes zoster auris (geniculate ganglionitis). (21012403)
1945
50
Syphilis Meningo-vascularis, Congenital Syphilis, Choroiditis, Optic Atrophy, Herpes Zoster, Multiple Root Lesions. (19978797)
1915

Genetic Variations for Herpes Zoster

Expression for genes affiliated with Herpes Zoster

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Herpes Zoster

Search GEO for disease gene expression data for Herpes Zoster.

Pathways for genes affiliated with Herpes Zoster

Sources:
30KEGG
See all sources

Pathways related to Herpes Zoster according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0MS4A1, CD8A, CD9

Compounds for genes affiliated with Herpes Zoster

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Herpes Zoster according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6CD79A
2bv-arau4510.6TKT, DPYD
3bvdu4510.6TKT, DPYD
4idurd4510.6TKT, DPYD
5mizoribine4510.5CD79A, IFNA2
6Ibritumomab1110.5FCGR3A, MS4A1
7tositumomab50 1111.5FCGR3A, MS4A1
8cidofovir45 1111.5TKT, IFNA2
9vidarabine45 1111.5TKT, IFNA2
10gamma globulin4510.5IFNA2, CD79A
115-deoxy-5-fluorouridine4510.5IFNA2, DPYD, TKT
12foscarnet45 1111.4TKT, CD9
13fudr4510.4IFNA2, DPYD, TKT
14con a4510.4HP, CD79A, IFNA2
15ivig4510.4FCGR3A, CD79A, CCR5
16didanosine45 1111.4TKT, CD9, IFNA2
17ribavirin45 50 1112.4CCR5, IFNA2, HP
18adefovir4510.4IFNA2, TKT
19acyclovir45 1111.4TKT, CD9, IFNA2
20diethyl dithiocarbamate4510.4TKT, CD9, IFNA2
21pyrimidine nucleoside4510.4TKT, DPYD
22vinblastine45 50 1112.4TUBA1A, IFNA2, TKT
23leucovorin45 50 1112.4IFNA2, DPYD, TKT, TMPO
24orotic acid45 11 2412.4DPYD, TKT
25neopterin4510.3IFNA2, CD9, CD79A, HP
26mannose4510.3CCR5, CD9, CD79A, FCGR3A
27polyethylene glycol4510.3IFNA2, CD9, CD79A, HP
28methotrexate45 50 1112.3DPYD, CD79A, TKT, FCGR3A
295fluorouracil4510.3IFNA2, DPYD, TKT, TMPO
30vitamin-e4510.2HP, IFNA2, CCR5
31rituximab45 50 1112.2MS4A1, FCGR3A, HP, CD79A, IFNA2
32methionine4510.2TMPO, HP, IFNA2, CCR5
33purine45 2411.2CD9, DPYD, IFNA2
34tomudex4510.2TKT, DPYD
35nucleoside4510.2CCR5, IFNA2, DPYD, HP, TKT
36zidovudine45 1111.2CCR5, IFNA2, CD9, TKT, TMPO
37benzidine4510.2TKT, HP
38mitomycin c4510.1TKT, DPYD, IFNA2
39azathioprine45 50 2 1113.1IFNA2, DPYD, CD79A
40paraffin4510.1DPYD, CD9, CD79A, TKT, MS4A1
41ascorbic acid45 2411.1IFNA2, CD9, CD79A, HP, TKT
42iron45 2411.1IFNA2, NDUFB8, DPYD, CD9, HP
43polysaccharide4510.1CCR5, CD9, CD79A, HP
44thymidine45 2411.1IFNA2, GYPC, DPYD, CD9, TKT
45thymidylate459.9IFNA2, DPYD, TKT
46alanine459.9CCR5, IFNA2, GYPC, CD9, CD79A, HP
47tuberculin459.9HP, CD79A
48cysteine459.8CCR5, IFNA2, DPYD, CD9, CD79A, HP
49tyrosine459.5CCR5, IFNA2, GYPC, DPYD, CD9, CD8A

GO Terms for genes affiliated with Herpes Zoster

Sources:
16Gene Ontology
See all sources

Cellular components related to Herpes Zoster according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6MS4A1, FCGR3A, CD8A, CD79A, CD9, CCR5

Biological processes related to Herpes Zoster according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069559.9MS4A1, FCGR3A, CD8A, CCR5

Products for genes affiliated with Herpes Zoster

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Herpes Zoster

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet