MCID: HDR003
MIFTS: 43

Hidradenitis malady

Skin diseases category
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Summaries for Hidradenitis

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Hidradenitis is any disease in which the histologic abnormality is primarily an inflammatory infiltrate... more...

MalaCards: Hidradenitis, also known as hydradenitis, is related to hidradenitis suppurativa and keratosis. An important gene associated with Hidradenitis is PSENEN (presenilin enhancer gamma secretase subunit), and among its related pathways are Notch signaling pathway and Development NOTCH1 mediated pathway for NF KB activity modulation. The compounds tazarotene and isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, myeloid and lymph node, and related mouse phenotype mortality/aging.

Aliases & Classifications for Hidradenitis

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8Disease Ontology, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

hidradenitis 8 62
hydradenitis 8


External Ids:

Disease Ontology8 DOID:2282
MeSH35 D016575
ICD9CM27 705.83

Related Diseases for Hidradenitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hidradenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenitis suppurativa32.0NCSTN, PSENEN
2keratosis29.8KRT10, KRT1
3acne10.8
4crohn's disease10.5
5pyoderma gangrenosum10.4
6pyoderma10.4
7arthritis10.3
8cellulitis10.3
9psoriasis10.3
10leukemia10.3
11spondyloarthropathy10.3
12degos disease10.3
13dissecting cellulitis of the scalp10.3
14dowling-degos disease10.3
15keratitis10.2
16arthropathy10.1
17interstitial keratitis10.1
18vasculitis10.1
19fox fordyce disease10.1
20urethritis10.1
21reactive arthritis10.1
22pachyonychia congenita10.1
23amyloidosis10.1
24lymphedema10.1
25nephrotic syndrome10.1
26steatocystoma multiplex10.1
27blindness10.1
28pyoderma gangrenosum - acne - suppurative hidradenitis10.1
29epidermolytic acanthoma10.1KRT1
30arrhythmogenic right ventricular dysplasia10.0DSC2, DSG2
31ichthyosis, cyclic, with epidermolytic hyperkeratosis10.0KRT10, KRT1
32bowen syndrome10.0KRT1, KRT10
33palmoplantar keratosis10.0KRT1, KRT10
34epidermolytic hyperkeratosis10.0KRT1, KRT10
35congenital ichthyosiform erythroderma10.0KRT1, KRT10
36epidermolysis bullosa simplex10.0KRT10, KRT1
37nonepidermolytic palmoplantar keratoderma10.0KRT10, KRT1
38noonan syndrome10.0DSG2, DSC2
39lichen planus10.0KRT1, KRT10
40skin disease10.0KRT1, KRT10
41cervical cancer9.9KRT1, KRT10
42alzheimer's disease9.9PSENEN, NCSTN, KRT1
43ankylosing spondylitis9.9
44reflex sympathetic dystrophy9.9
45sialadenitis9.9
46ulcerative colitis9.9
47hypercalcemia9.9
48mucinous adenocarcinoma9.9
49sapho syndrome9.9
50orbital cellulitis9.9

Graphical network of the top 20 diseases related to Hidradenitis:



Diseases related to hidradenitis

Symptoms for Hidradenitis

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Drugs & Therapeutics for Hidradenitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Hidradenitis

Genetic Tests for Hidradenitis

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Anatomical Context for Hidradenitis

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33MalaCards
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MalaCards organs/tissues related to Hidradenitis:

33
Skin, Myeloid, Lymph node, Lung, Breast, Pituitary

Animal Models for Hidradenitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hidradenitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.7KRT1, KRT10, NCSTN, PSENEN, DSG2

Publications for Hidradenitis

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52PubMed
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Articles related to Hidradenitis:

(show top 50)    (show all 577)
idTitleAuthorsYear
1
Successful treatment of severe hidradenitis suppurativa with anakinra. (23966107)
2013
2
Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis. (24011308)
2013
3
Phenotypic heterogeneity in hidradenitis suppurativa (acne inversa): classification is an essential step toward personalized therapy. (23673498)
2013
4
Hidradenitis suppurativa and multiple dermatofibromas in a patient with ulcerative colitis. (24330184)
2013
5
Absence of pathogenic I^-secretase mutations in a South Wales cohort of familial and sporadic hidradenitis suppurativa (acne inversa). (23013355)
2013
6
Treatment of moderate to severe hidradenitis suppurativa. (23817709)
2013
7
Islanded perforator flaps in the reconstruction of hidradenitis suppurativa defects. (23303517)
2013
8
Predicting response to anti-TNF-alpha treatment in Hidradenitis suppurativa. (23362964)
2013
9
Axillary hidradenitis. (23359851)
2013
10
Clinical practice. Hidradenitis suppurativa. (22236226)
2012
11
Interstitial keratitis secondary to severe hidradenitis suppurativa responding to adalimumab. (22146546)
2012
12
Alterations in leucocyte subsets and histomorphology in normal-appearing perilesional skin and early and chronic hidradenitis suppurativa lesions. (21929531)
2012
13
Radical surgical excision and use of lateral thoracic flap for intractable axillary hidradenitis suppurativa. (23233895)
2012
14
Bacteriology of hidradenitis suppurativa exacerbations and deep tissue cultures obtained during carbon dioxide laser treatment. (22098253)
2012
15
Surgical treatment of chronic hidradenitis suppurativa in the gluteal and perianal regions. (23373365)
2012
16
Extended latissimus dorsi rotational V-Y advancement flap for the reconstruction of axillary defects after excision of hidradenitis suppurativa. (22374031)
2012
17
The thoracodorsal artery perforator flap in the treatment of axillary hidradenitis suppurativa: effect on preservation of arm abduction. (21921770)
2011
18
The perils of a defective medical communication: fatal neglected squamous cell carcinoma arising in perineal hidradenitis suppurativa. (21897818)
2011
19
Management of regional hidradenitis suppurativa with vacuum-assisted closure and split thickness skin grafts. (21587057)
2011
20
Superior and inferior gluteal artery perforator flaps in reconstruction of gluteal and perianal/perineal hidradenitis suppurativa lesions. (21976179)
2011
21
Dermacase. Can you identify this condition? Hidradenitis suppurativa. (21918148)
2011
22
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. (20628295)
2010
23
Hyperbaric oxygen therapy for the management of postsurgical wounds in hidradenitis suppurativa. (21352679)
2010
24
Hidradenitis suppurativa (or Acne inversa) with autosomal dominant inheritance is not linked to chromosome 1p21.1-1q25.3 region. (20698881)
2010
25
Effective long-term control of refractory hidradenitis suppurativa with adalimumab after failure of conventional therapy. (21091684)
2010
26
Hidradenitis suppurativa. (20883920)
2010
27
Biologic drugs for the treatment of hidradenitis suppurativa: an evidence-based review. (20510761)
2010
28
Lymph nodes in hidradenitis suppurativa. (19365106)
2009
29
Etanercept for the treatment of hidradenitis suppurativa. (19197548)
2009
30
Hidradenitis suppurativa: importance of early treatment; efficient treatment with electrosurgery. (18093196)
2008
31
Quality of life impairment in hidradenitis suppurativa: a study of 61 cases. (17097366)
2007
32
Real-time compound imaging ultrasound of hidradenitis suppurativa. (17958586)
2007
33
A hidradenitis suppurativa related SAPHO case associated with features resembling spondylarthropathy and proteinuria. (16680392)
2007
34
The cutting edge. Severe hidradenitis suppurativa treated with adalimumab. (16982997)
2006
35
Surgical treatment of hidradenitis suppurativa: case series and review of the literature. (16984573)
2006
36
Clindamycin and rifampicin combination therapy for hidradenitis suppurativa. (16634904)
2006
37
Etanercept: effective in the management of hidradenitis suppurativa. (16536817)
2006
38
Treatment of long-standing extensive perianal hidradenitis suppurativa using double rotation plasty, V-Y plasty and free grafts. (12838364)
2004
39
Hidradenitis suppurativa. (12457209)
2003
40
Vulvar hidradenitis suppurativa. Immunohistochemical evaluation of apocrine and eccrine involvement. (12380447)
2002
41
Split-thickness skin grafts and negative-pressure dressings in the treatment of axillary hidradenitis suppurativa. (12479426)
2002
42
Hidradenitis suppurativa. (11193069)
2000
43
The natural history of hidradenitis suppurativa. (11305381)
2000
44
Neutrophilic eccrine hidradenitis. (10856664)
2000
45
Cigarette smoking as a triggering factor of hidradenitis suppurativa. (10393449)
1999
46
Pyoderma gangrenosum associated with cystic acne and hidradenitis suppurativa controlled by adding minocycline and sulfasalazine to the treatment regimen. (8726710)
1996
47
Cyclosporin-responsive hidradenitis suppurativa. (7636825)
1995
48
Surgical management of severe mammary hidradenitis suppurativa. (3341719)
1988
49
Hidradenitis suppurativa of the anogenital region: response to isotretinoin. (3422131)
1988
50
Fox-Fordyce disease with hidradenitis suppurativa. (13563958)
1958

Variations for Hidradenitis

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Expression for genes affiliated with Hidradenitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hidradenitis

Search GEO for disease gene expression data for Hidradenitis.

Pathways for genes affiliated with Hidradenitis

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Sources:
50PathCards, 30KEGG, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 60Thomson Reuters, 5Cell Signaling Technology, 54R&D Systems
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Pathways related to Hidradenitis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Delta-Notch Signaling Pathway38
Notch Signaling Pathway38
9.6NCSTN, PSENEN
2
Show member pathways
Development Notch Signaling Pathway60
Transcription Sin3 and NuRD in transcription regulation60
9.6NCSTN, PSENEN
3
Show member pathways
9.6NCSTN, PSENEN
4
Show member pathways
9.6NCSTN, PSENEN
5
Show member pathways
Alzheimers Disease38
9.6NCSTN, PSENEN
69.6NCSTN, PSENEN
79.6NCSTN, PSENEN
89.6PSENEN, NCSTN
9
Show member pathways
9.6PSENEN, NCSTN
10
Show member pathways
9.6NCSTN, PSENEN
11
Show member pathways
9.6NCSTN, PSENEN
129.6NCSTN, PSENEN
13
Show member pathways
Notch signaling pathway38
9.6NCSTN, PSENEN
149.6NCSTN, PSENEN
15
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.3DSC2, DSG2

Compounds for genes affiliated with Hidradenitis

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45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB
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Compounds related to Hidradenitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tazarotene45 1110.2KRT1, KRT10
2isotretinoin45 1110.2KRT1, KRT10
3isoleucine459.1KRT1, KRT10
4bromodeoxyuridine459.1KRT1, KRT10
5hematoxylin459.0KRT10, KRT1
6calcium45 51 24 1110.7KRT1, KRT10, DSG2, DSC2

GO Terms for genes affiliated with Hidradenitis

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16Gene Ontology
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Cellular components related to Hidradenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300579.2DSG2, DSC2
2keratin filamentGO:0450959.1KRT1, KRT10
3extracellular vesicular exosomeGO:0700627.5KRT1, KRT10, NCSTN, DSG2, DSC2
4plasma membraneGO:0058867.3DSC2, DSG2, PSENEN, NCSTN, KRT1

Biological processes related to Hidradenitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1amyloid precursor protein catabolic processGO:0429879.9NCSTN, PSENEN
2membrane protein intracellular domain proteolysisGO:0312939.8NCSTN, PSENEN
3membrane protein ectodomain proteolysisGO:0065099.8NCSTN, PSENEN
4Notch receptor processingGO:0072209.7PSENEN, NCSTN
5protein processingGO:0164859.7NCSTN, PSENEN
6positive regulation of catalytic activityGO:0430859.6NCSTN, PSENEN
7bundle of His cell to Purkinje myocyte communicationGO:0860699.6DSG2, DSC2
8ventricular cardiac muscle cell action potentialGO:0860059.5DSC2, DSG2
9apoptotic signaling pathwayGO:0971909.5PSENEN, NCSTN
10regulation of heart rate by cardiac conductionGO:0860919.5DSG2, DSC2
11homophilic cell adhesionGO:0071569.3DSG2, DSC2
12Notch signaling pathwayGO:0072199.3NCSTN, PSENEN

Products for genes affiliated with Hidradenitis

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  • Antibodies
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Sources for Hidradenitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet