MCID: HDR003
MIFTS: 45

Hidradenitis malady

Categories: Skin diseases

Aliases & Classifications for Hidradenitis

Aliases & Descriptions for Hidradenitis:

Name: Hidradenitis 12 42 14 69
Hydradenitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2282
ICD9CM 35 705.83
MeSH 42 D016575
NCIt 47 C112190
UMLS 69 C0085160

Summaries for Hidradenitis

MalaCards based summary : Hidradenitis, also known as hydradenitis, is related to squamous cell carcinoma and hidradenitis suppurativa. An important gene associated with Hidradenitis is NCSTN (Nicastrin), and among its related pathways/superpathways are Developmental Biology and Th17 cell differentiation. The drugs Adalimumab and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and myeloid, and related phenotypes are craniofacial and hematopoietic system

Wikipedia : 71 Hidradenitis is any disease in which the histologic abnormality is primarily an inflammatory infiltrate... more...

Related Diseases for Hidradenitis

Diseases related to Hidradenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
id Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 30.3 KRT10 KRT14
2 hidradenitis suppurativa 12.5
3 pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 11.8
4 acne inversa, familial, 1 11.0
5 perifolliculitis capitis abscedens et suffodiens, familial 10.8
6 acne inversa, familial, 3 10.8
7 acne inversa, familial, 2 10.8
8 acne 10.4
9 dermatosis papulosa nigra 10.2 NOD2 TNF
10 amyotrophic lateral sclerosis type 5 10.2 NOD2 TNF
11 psoriatic arthritis 10.2 NOD2 TNF
12 stomach carcinoma in situ 10.2 NCSTN PSENEN
13 odontogenic myxoma 10.2 IL17A NOD2
14 dermatitis herpetiformis 10.2 IL17A TNF
15 amyotrophic lateral sclerosis type 14 10.2 NOD2 TNF
16 intermediate malignant teratoma 10.2 NCSTN PSEN1 PSENEN
17 aniseikonia 10.2 IL17A TNF
18 meier-gorlin syndrome 3 10.1 NOD2 TNF
19 pick disease 10.1 DSG2 PSEN1
20 nemaline myopathy 1, autosomal dominant or recessive 10.1 NCSTN PSENEN TNF
21 crohn's disease 10.1
22 juvenile amyotrophic lateral sclerosis with dementia 10.1 DSG2 TNF
23 pyoderma 10.1
24 pyoderma gangrenosum 10.1
25 scleroperikeratitis 10.1 KRT14 NCSTN PSENEN
26 ebola hemorrhagic fever 10.1 KRT10 KRT14
27 trichomalacia 10.1 IL17A TNF
28 anal margin basal cell carcinoma 10.1 KRT10 KRT14
29 mixed cell adenoma 10.1 KRT10 KRT14
30 histiocytoma 10.1 NOD2 TNF
31 dowling-degos disease 1 10.1 KRT10 KRT14
32 parkinson disease 11 10.1 IL17A NOD2 TNF
33 gastric dilatation 10.0 IL17A TNF
34 crohn's colitis 10.0 IL17A NOD2 TNF
35 celiac disease 10.0 IL17A NOD2 TNF
36 endobronchial leiomyoma 10.0 IL17A NOD2 TNF
37 uterine ligament clear cell adenocarcinoma 10.0 IL17A NOD2 TNF
38 esophageal candidiasis 10.0 IL17A NOD2 TNF
39 basaloid squamous cell carcinoma 10.0 KRT10 KRT14
40 molybdenum cofactor deficiency a 10.0 IL17A NOD2 TNF
41 childhood malignant hemangiopericytoma 10.0 IL17A NOD2 TNF
42 collagenous colitis 10.0 IL17A NOD2 TNF
43 thymus mucoepidermoid carcinoma 10.0 IL17A KRT10
44 substance-induced psychosis 10.0 IL17A PSEN1 TNF
45 epidermolysis bullosa 10.0 IL17A NOD2 TNF
46 epithelioid type angiomyolipoma 10.0 IL17A PSEN1 TNF
47 malignant histiocytosis 10.0 NOD2 TNF
48 pigmented nodular adrenocortical disease, primary, 4 10.0 IL12RB1 NOD2
49 acute kidney failure 10.0 NCSTN PSEN1 PSENEN TNF
50 glycogen storage disease ix 10.0 IL17A NOD2 TNF

Graphical network of the top 20 diseases related to Hidradenitis:



Diseases related to Hidradenitis

Symptoms & Phenotypes for Hidradenitis

MGI Mouse Phenotypes related to Hidradenitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.72 IL17A KRT14 NCSTN PSEN1 TNF
2 hematopoietic system MP:0005397 9.7 IL12RB1 IL17A KRT14 NCSTN NOD2 PSEN1
3 digestive/alimentary MP:0005381 9.65 IL17A KRT14 NOD2 PSEN1 TNF
4 immune system MP:0005387 9.5 KRT14 NCSTN NOD2 PSEN1 TNF IL12RB1
5 mortality/aging MP:0010768 9.23 DSG2 IL17A KRT14 NCSTN NOD2 PSEN1

Drugs & Therapeutics for Hidradenitis

Drugs for Hidradenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
2 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
3 Antirheumatic Agents Phase 4,Phase 3,Phase 2
4 Anti-Bacterial Agents Phase 3,Phase 2
5 Antibiotics, Antitubercular Phase 3
6
Etanercept Approved, Investigational Phase 2 185243-69-0
7
Infliximab Approved Phase 2 170277-31-3
8
Ustekinumab Approved, Investigational Phase 2 815610-63-0
9
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
10
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757 53477783
11
Drospirenone Approved Phase 2 67392-87-4 68873
12
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
13 Dermatologic Agents Phase 2
14 Hormone Antagonists Phase 2
15 Hormones Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
17 Anti-Infective Agents Phase 2,Phase 1
18 Immunosuppressive Agents Phase 2
19 Analgesics Phase 2
20 Gastrointestinal Agents Phase 2
21 Analgesics, Non-Narcotic Phase 2
22 Peripheral Nervous System Agents Phase 2
23 Immunoglobulins Phase 2,Phase 1,Early Phase 1
24 Antibodies, Monoclonal Phase 2,Phase 1,Early Phase 1
25 Interleukin 1 Receptor Antagonist Protein Phase 2
26 Anti-Inflammatory Agents, Non-Steroidal Phase 2
27 Antibodies Phase 2,Phase 1,Early Phase 1
28 Angiogenesis Inhibitors Phase 2
29 Angiogenesis Modulating Agents Phase 2
30 Complement System Proteins Phase 2
31 Estradiol valerate Phase 2 979-32-8
32 diuretics Phase 2
33 Natriuretic Agents Phase 2
34 Contraceptive Agents Phase 2
35 Contraceptives, Oral Phase 2
36 Diuretics, Potassium Sparing Phase 2
37 Drospirenone and ethinyl estradiol combination Phase 2
38 Estradiol 17 beta-cypionate Phase 2
39 Estradiol 3-benzoate Phase 2
40 Estrogens Phase 2
41 Polyestradiol phosphate Phase 2
42 Mineralocorticoid Receptor Antagonists Phase 2
43 Mineralocorticoids Phase 2
44
Phenol Approved, Experimental Phase 1 108-95-2 996
45 Pharmaceutical Solutions Phase 1
46 Anesthetics Phase 1
47 Disinfectants Phase 1
48 Anti-Infective Agents, Local Phase 1
49
Rifampin Approved 13292-46-1 5458213 5381226
50
Triamcinolone Approved, Vet_approved 124-94-7 31307

Interventional clinical trials:

(show all 47)
id Name Status NCT ID Phase
1 Safety and Efficacy of Humira (Adalimumab) for Hidradenitis Suppurativa (HS) Peri-Surgically (SHARPS Study) Recruiting NCT02808975 Phase 4
2 Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa Completed NCT01468207 Phase 3
3 Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa Completed NCT01468233 Phase 3
4 Open-label Study of the Safety and Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa Completed NCT01635764 Phase 3
5 Open-label Study of Adalimumab in Japanese Subjects With Hidradenitis Suppurativa Recruiting NCT02904902 Phase 3
6 Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa Recruiting NCT02805595 Phase 3
7 To Determine the Efficacy of a Laser Device for the Treatment of Hidradenitis Suppurativa Terminated NCT00367328 Phase 3
8 To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa Completed NCT00827996 Phase 2
9 Etanercept in Hidradenitis Suppurativa Completed NCT00329823 Phase 2
10 Study to Assess the Safety and Efficacy of Infliximab to Treat Hidradenitis Suppurtativa Completed NCT00795574 Phase 2
11 Etanercept for Treatment of Hidradenitis Completed NCT00107991 Phase 2
12 Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa Patients Completed NCT02421172 Phase 2
13 Anakinra as a Treatment for Hydradenitis Suppurativa Completed NCT01516749 Phase 2
14 Anakinra in Hidradenitis Suppurativa Completed NCT01558375 Phase 2
15 A Proof of Concept Study to Evaluate the Effectiveness of Ustekinumab in Hidradenitis Suppurativa Completed NCT01704534 Phase 2
16 Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa Completed NCT00918255 Phase 2
17 MABp1 IN HIDRADENITIS SUPPURATIVA REFRACTORY TO ADALIMUMAB Completed NCT02643654 Phase 2
18 Single Center Study of Apremilast for the Treatment of Hidradenitis Suppurativa Recruiting NCT02695212 Phase 2
19 Short-term Safety, Efficacy and Mode of Action of Apremilast in Moderate Suppurative Hidradenitis Recruiting NCT03049267 Phase 2
20 Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa Active, not recruiting NCT03001622 Phase 2
21 Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis Suppurativa Terminated NCT01838499 Phase 2
22 A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HS Terminated NCT00722800 Phase 2
23 Efficacy and Safety of Efalizumab in the Treatment of Moderate-Severe Hydradenitis Suppurativa Completed NCT00134134 Phase 1
24 Endoscopic Pilonidal Sinus Treatment With Additional Crystalized Phenol Completed NCT02277340 Phase 1
25 An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa. Unknown status NCT01818167
26 Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical Deroofing Unknown status NCT02163746
27 Trial Comparing Efficacy of Treatments for Hidradenitis Suppurativa Unknown status NCT01063270
28 Efficacy of Percutaneous Injection of Triamcinolone in the Treatment of Mammillary Fistula Unknown status NCT01315080
29 Study on the Effect of NdYag Laser for the Treatment of Hidradenitis Suppurativa Completed NCT00494351
30 A Small Clinical Study: Photodynamic Therapy to Treat Hidradenitis Suppurativa Completed NCT00395187
31 Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients Completed NCT02833909
32 Treatment of Hidradenitis Suppurativa Using Etanercept Completed NCT00949546
33 Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients - a Multi cOuNtry studY in Real Life Setting Recruiting NCT02786576
34 Post-Marketing Surveillance of Adalimumab in Korean Hidradenitis Suppurativa Subjects Recruiting NCT03001115
35 A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa. Recruiting NCT02781818
36 Treatment of Hidradenitis Suppurativa With Eth 755nm Alexandrite Laser Recruiting NCT03054155
37 Group Psychotherapy for Patients With Hidradenitis Suppurativa: Effects in Quality of Life Recruiting NCT02904408
38 Low Dose Radiotherapy for Advanced Hidradenitis Suppurativa Recruiting NCT03040804
39 Post Marketing Observational Study (PMOS) to Assess Quality of Life in Swedish Hidradenitis Suppurativa (HS) Patients Recruiting NCT02739828
40 Exploratory Trial Evaluating Cosentyx (Secukinumab) for Patients With Moderate-to-Severe Hidradenitis Suppurativa Recruiting NCT03099980 Early Phase 1
41 Pilot Study on Botulinum Toxin B as Treatment for Hidradenitis Suppurativa Recruiting NCT03103074
42 Canadian Humira Post Marketing Observational Epidemiological Study : Assessing Humira Real-life Effectiveness and Impact on HS Burden of Illness Recruiting NCT02896920
43 The Ohio State University Dermatology Biorepository, Molecular Biology and Genetics of Hidradenitis Suppurativa Recruiting NCT03146676
44 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275
45 Quality of Life After Wide Surgical Excision in Patients With Hidradenitis Suppurativa Enrolling by invitation NCT02593604
46 Patients With Hidradenitis vs Patients With Psoriasis: Psychological Impact Not yet recruiting NCT02999698
47 Chronic Inflammatory Disease, Lifestyle and Treatment Response Not yet recruiting NCT03173144

Search NIH Clinical Center for Hidradenitis

Cochrane evidence based reviews: hidradenitis

Genetic Tests for Hidradenitis

Anatomical Context for Hidradenitis

MalaCards organs/tissues related to Hidradenitis:

39
Neutrophil, Skin, Myeloid, Lung, Monocytes, Endothelial, Pituitary

Publications for Hidradenitis

Articles related to Hidradenitis:

(show top 50) (show all 720)
id Title Authors Year
1
Factors Contributing to Depression and Chronic Pain in Patients with Hidradenitis Suppurativa: Results from a Single-Center Retrospective Review. ( 28068657 )
2017
2
Interferon-gamma (IFN-I^) is Elevated in Wound Exudate from Hidradenitis Suppurativa. ( 27819528 )
2017
3
Quality of Life and Psychosocial Implications in Patients with Hidradenitis Suppurativa. ( 28052274 )
2017
4
Weekly adalimumab significantly reduces the number of abscesses and inflammatory nodules in patients with moderate to severe hidradenitis suppurativa. ( 28053204 )
2017
5
Response to: 'Autoinflammatory disease damage index (ADDI): a possible newborn also in hidradenitis suppurativa daily practice' by Damiani et al. ( 28043999 )
2017
6
Prevalence and risk of inflammatory bowel disease in patients with hidradenitis suppurativa. ( 28089682 )
2017
7
Hidradenitis suppurativa treated with tetracycline in combination with colchicine: a prospective series of 20 patients. ( 28054351 )
2017
8
Body fat composition in hidradenitis suppurativa: a hospital-based cross-sectional study. ( 28084004 )
2017
9
Population Pharmacokinetics and Immunogenicity of Adalimumab in Adult Patients with Moderate-to-Severe Hidradenitis Suppurativa. ( 28066879 )
2017
10
Pyoderma Gangrenosum, Acne and Suppurative Hidradenitis Syndrome Treated with Granulocyte and Monocyte Adsorption Apheresis. ( 27384061 )
2016
11
Bacterial Biofilm in Chronic Lesions of Hidradenitis Suppurativa. ( 27564400 )
2016
12
Adalimumab: A Review in Hidradenitis Suppurativa. ( 27665300 )
2016
13
Clinical experience of the use of adalimumab in the management of hidradenitis suppurativa. Comparison of response rates with Crohn disease. ( 28081769 )
2016
14
Accelerated wound healing after wide excisions in Hidradenitis Suppurativa using autologous split-thickness skin grafting and platelet-rich plasma. ( 27611792 )
2016
15
Intrinsic defect in keratinocyte function leads to inflammation in Hidradenitis suppurativa. ( 27206704 )
2016
16
Reply to Revuz' Letter Entitled 'Hidradenitis Suppurativa: Terminology'. ( 27159977 )
2016
17
Reduction in pain scores and improvement in depressive symptoms in patients with hidradenitis suppurativa treated with adalimumab in a phase 2, randomized, placebo-controlled trial. ( 27136622 )
2016
18
When inflammation shifts to malignancy: extensive squamous cell carcinoma in a female hidradenitis suppurativa/acne inversa patient. ( 28036145 )
2016
19
Management of hidradenitis suppurativa. ( 27585997 )
2016
20
Hidradenitis suppurativa and perianal Crohn disease: differential diagnosis. ( 28081767 )
2016
21
Combination of oral zinc gluconate and topical triclosan: An anti-inflammatory treatment modality for initial hidradenitis suppurativa. ( 27554338 )
2016
22
Qualitative study shows disease damage matters to patients with hidradenitis suppurativa. ( 27185436 )
2016
23
Hidradenitis suppurativa: A disease of infundibular epidermis, rather than pilosebaceous units? ( 27542326 )
2016
24
Diagnoses of Hidradenitis Suppurativa in the United States, 1979-2012. ( 27171648 )
2016
25
Oral clindamycin and rifampicin in the treatment of hidradenitis suppurativa-acne inversa: can some factors influence the response to the treatment? ( 27068603 )
2016
26
Hidradenitis suppurativa patients have no increased risk of Alzheimer's disease. ( 27639074 )
2016
27
The Hidradenitis suppurativa patient journey in Italy: current status, unmet needs and opportunities. ( 27136185 )
2016
28
Ustekinumab, another biologic with potential to help patients with hidradenitis suppurativa? ( 27115586 )
2016
29
High Copy Numbers of Beta-Defensin Cluster on 8p23.1 Confer Genetic Susceptibility and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa. ( 27164300 )
2016
30
Hidradenitis suppurativa (HS) and Down syndrome (DS): Increased prevalence and a younger age of hidradenitis symptom onset. ( 27543219 )
2016
31
Epidemiological, clinical and therapeutic aspects in special situations: hidradenitis suppurativa in paediatric patients. ( 28081770 )
2016
32
Management of hidradenitis suppurativa in pregnancy. ( 28040373 )
2016
33
Primary Cutaneous Plasmacytosis: Masquerading as Hidradenitis Suppurativa. ( 27057027 )
2016
34
Hidradenitis suppurativa-acne inversa-like lesions complicating naevus comedonicus: second case supporting the mechanical stress as a triggering factor. ( 27176082 )
2016
35
Recalcitrant Hidradenitis Suppurativa: An Investigation of Demographics, Surgical Management, Bacterial Isolates, Pharmacologic Intervention, and Patient-reported Health Outcomes. ( 27097631 )
2016
36
Regional variation of Hidradenitis suppurativa in the Norwegian Patient Registry (NPR) during 5 years period may describe professional awareness of the disease not changes in prevalens. ( 27543427 )
2016
37
Hidradenitis suppurativa is not associated with the metabolic syndrome based on body type: A cross-sectional study. ( 27608328 )
2016
38
Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: Implications for treatment with anti-IL-17 agents. ( 28041632 )
2016
39
Hidradenitis Suppurativa and Inflammatory Bowel Disease: A Cross-Sectional Study of 3,207 Patients. ( 27094593 )
2016
40
Interventions for hidradenitis suppurativa: an important step towards evidence-based medicine. ( 27206354 )
2016
41
What Heals Hidradenitis Suppurativa: Surgery, Immunosuppression, or Both? ( 27556765 )
2016
42
Discussion: What Heals Hidradenitis Suppurativa: Surgery, Immunosuppression, or Both? ( 27556766 )
2016
43
Hidradenitis Suppurativa and the Association With Hematological Malignancies: A Review of 2 Cases. ( 27573126 )
2016
44
Management of patients with hidradenitis suppurativa. ( 28081768 )
2016
45
Neutrophilic Eccrine Hidradenitis in a Child with Chronic Granulomatous Disease. ( 27904195 )
2016
46
Phenotypic Characterization of Patients with Hidradenitis Suppurativa. ( 27576734 )
2016
47
Management of Hidradenitis Suppurativa in Patients with Metabolic Comorbidities. ( 27081259 )
2016
48
Hidradenitis Suppurativa: Terminology. ( 27161332 )
2016
49
Successful treatment of widespread chronic gluteal hidradenitis suppurativa with combination of recycled skin graft and negative-pressure wound therapy. ( 27651126 )
2016
50
Therapeutic approach to Crohn disease: possible parallels with hidradenitis suppurativa. ( 28081765 )
2016

Variations for Hidradenitis

Expression for Hidradenitis

Search GEO for disease gene expression data for Hidradenitis.

Pathways for Hidradenitis

Pathways related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 DSG2 KRT10 KRT14 NCSTN PSENEN TNF
2
Show member pathways
12.27 IL12RB1 IL17A NOD2 TNF
3 11.97 NCSTN PSEN1 PSENEN
4
Show member pathways
11.93 NCSTN PSEN1 PSENEN
5 11.82 NCSTN PSEN1 PSENEN
6
Show member pathways
11.66 IL12RB1 IL17A TNF
7 11.48 IL12RB1 IL17A TNF
8
Show member pathways
11.36 NCSTN PSEN1 PSENEN
9 11.2 NCSTN PSEN1 PSENEN
10 11.05 IL17A TNF
11 10.99 NCSTN PSEN1 PSENEN
12 10.87 NOD2 TNF
13 10.55 NCSTN PSEN1 PSENEN
14 10.03 NCSTN PSEN1 PSENEN
15 10.02 PSEN1 PSENEN

GO Terms for Hidradenitis

Cellular components related to Hidradenitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.33 IL12RB1 IL17A TNF
2 cell surface GO:0009986 9.26 DSG2 NOD2 PSEN1 TNF
3 gamma-secretase complex GO:0070765 8.8 NCSTN PSEN1 PSENEN

Biological processes related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.75 DSG2 KRT10 KRT14
2 positive regulation of apoptotic process GO:0043065 9.73 NCSTN PSEN1 PSENEN TNF
3 Notch signaling pathway GO:0007219 9.67 NCSTN PSEN1 PSENEN
4 cornification GO:0070268 9.65 DSG2 KRT10 KRT14
5 positive regulation of interferon-gamma production GO:0032729 9.59 IL12RB1 TNF
6 positive regulation of interleukin-6 production GO:0032755 9.58 NOD2 TNF
7 positive regulation of catalytic activity GO:0043085 9.58 NCSTN PSEN1 PSENEN
8 positive regulation of interleukin-8 production GO:0032757 9.57 NOD2 TNF
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.56 NOD2 TNF
10 positive regulation of osteoclast differentiation GO:0045672 9.55 IL17A TNF
11 membrane protein intracellular domain proteolysis GO:0031293 9.54 NCSTN PSENEN
12 protein processing GO:0016485 9.54 NCSTN PSEN1 PSENEN
13 beta-amyloid metabolic process GO:0050435 9.52 NCSTN PSEN1
14 epithelial cell proliferation GO:0050673 9.51 NCSTN PSEN1
15 membrane protein ectodomain proteolysis GO:0006509 9.5 NCSTN PSEN1 PSENEN
16 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.46 IL17A NOD2
17 Notch receptor processing GO:0007220 9.43 NCSTN PSEN1 PSENEN
18 amyloid precursor protein metabolic process GO:0042982 9.33 NCSTN PSEN1 PSENEN
19 amyloid precursor protein catabolic process GO:0042987 9.13 NCSTN PSEN1 PSENEN
20 beta-amyloid formation GO:0034205 8.8 NCSTN PSEN1 PSENEN

Sources for Hidradenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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