MCID: HDR003
MIFTS: 45

Hidradenitis malady

Summaries for Hidradenitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Hidradenitis is any disease in which the histologic abnormality is primarily an inflammatory infiltrate... more...

MalaCards: Hidradenitis, also known as hydradenitis, is related to hidradenitis suppurativa and acne. An important gene associated with Hidradenitis is PSENEN (presenilin enhancer gamma secretase subunit), and among its related pathways are Signaling by NOTCH3 and Notch Pathway. The compounds mrk 560 and jlk 6 have been mentioned in the context of this disorder. Related mouse phenotypes are integument and craniofacial.

Aliases & Classifications for Hidradenitis

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH
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Aliases & Descriptions:

hidradenitis 8 61
hydradenitis 8


External Ids:

Disease Ontology8 DOID:2282
ICD9CM27 705.83
MeSH35 D016575

Related Diseases for Hidradenitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hidradenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenitis suppurativa31.9NCSTN, PSENEN, TNFRSF1B
2acne31.1SHBG
3squamous cell carcinoma30.7TNFRSF1B, PIP, DSC2, DSG2, CYP1A1, KRT1
4arthropathy30.2NOD2, TNFRSF1B
5adenocarcinoma29.8PIP, CYP1A1, KRT1, KRT14, KRT10, KRT8
6crohn's disease10.5
7pyoderma gangrenosum10.4
8arthritis10.3
9cellulitis10.3
10spondyloarthropathy10.3
11degos disease10.3
12dowling-degos disease10.3
13pyoderma gangrenosum - acne - suppurative hidradenitis10.3
14n syndrome10.2
15acute leukemia10.2
16vasculitis10.1
17pachyonychia congenita10.1
18reactive arthritis10.1
19verrucous carcinoma10.1
20amyloidosis10.1
21vulva squamous cell carcinoma10.1
22steatocystoma multiplex10.1
23anal fistula10.1
24li-fraumeni syndrome10.0PIP
25ductal carcinoma in situ10.0KRT14
26basal cell carcinoma10.0SHH
27epidermolytic acanthoma10.0KRT1
28hypospadias10.0SRD5A1
29prostatitis10.0SRD5A1
30keratoacanthoma10.0KRT10
31keratosis10.0KRT1, KRT10
32lichen planus10.0KRT1, KRT10
33hidrocystoma10.0PIP
34hypogonadism10.0SHBG
35meningioma10.0HSD17B13, KRT1
36ovarian cancer10.0KRT8
37psoriatic arthritis10.0TNFRSF1B
38ichthyosis, cyclic, with epidermolytic hyperkeratosis10.0KRT1, KRT10
39keratoderma10.0KRT14, KRT1
40alopecia10.0SHBG
41syringoma10.0KRT14, KRT1
42cholesteatoma10.0KRT14, KRT10
43epidermolytic hyperkeratosis10.0KRT10, KRT1
44cervical intraepithelial neoplasia10.0KRT8, KRT10
45prolactinoma10.0PTHLH
46hepatoblastoma10.0SHBG
47papilloma10.0KRT10, KRT14
48polycystic ovary syndrome10.0SRD5A1, SHBG
49bowen syndrome10.0KRT10, KRT14, KRT1
50nonepidermolytic palmoplantar keratoderma10.0KRT10, KRT14, KRT1

Graphical network of the top 20 diseases related to Hidradenitis:



Diseases related to hidradenitis

Clinical Features for Hidradenitis

Drugs & Therapeutics for Hidradenitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hidradenitis

Drug clinical trials:

Search ClinicalTrials for Hidradenitis

Search NIH Clinical Center for Hidradenitis

Search CenterWatch for Hidradenitis

Genetic Tests for Hidradenitis

Anatomical Context for Hidradenitis

Animal Models for Hidradenitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hidradenitis

Sources:
51PubMed
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Articles related to Hidradenitis:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Oral clindamycin and rifampicin in the treatment of hidradenitis suppurativa-acne inversa: a prospective study on 23 patients. (23451831)
2014
2
Pyogenic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PAPASH): a new autoinflammatory syndrome associated with a novel mutation of the PSTPIP1 gene. (23571383)
2013
3
Myeloid marker S100A8/A9 and lymphocyte marker, soluble interleukin 2 receptor: biomarkers of hidradenitis suppurativa disease activity? (23320892)
2013
4
Is mechanical stress an important pathogenic factor in hidradenitis suppurativa? (22379963)
2012
5
Summaries for patients. Adalimumab for the treatment of hidradenitis suppurativa. (23247950)
2012
6
Nicastrin mutations in French families with hidradenitis suppurativa. (22358060)
2012
7
Flexural or inverse psoriasis in a patient with hidradenitis suppurativa receiving treatment with infliximab. (23149048)
2012
8
The thoracodorsal artery perforator flap in the treatment of axillary hidradenitis suppurativa: effect on preservation of arm abduction. (21921770)
2011
9
Efficacy of rifampin-moxifloxacin-metronidazole combination therapy in hidradenitis suppurativa. (21109728)
2011
10
Hidradenitis suppurativa: a review of cause and treatment. (21192260)
2011
11
Surgical Approach to Extensive Hidradenitis Suppurativa. (21492305)
2011
12
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. (20628295)
2010
13
Deroofing: a tissue-saving surgical technique for the treatment of mild to moderate hidradenitis suppurativa lesions. (20708472)
2010
14
Successful treatment of superficial pyoderma gangrenosum associated with hidradenitis suppurativa with adalimumab. (20804692)
2010
15
Treatment of hidradenitis suppurativa with infliximab. (20944927)
2010
16
Marjolin ulcer in hidradenitis suppurativa: case reports. (20179481)
2010
17
A case of hidradenitis suppurativa refractory to anti-TNFalpha therapy in a patient with Crohn's disease. (20054324)
2010
18
Prevalence of the MspI and Ile462Val SNPs of cytochrome P-450 1A1 in hidradenitis suppurativa. (20584197)
2010
19
Hidradenitis suppurativa in AIDS. (21808438)
2010
20
Increased serum tumour necrosis factor-alpha in hidradenitis suppurativa patients: is there a basis for treatment with anti-tumour necrosis factor-alpha agents? (19997690)
2009
21
Long-standing hidradenitis suppurativa treated effectively with metformin. (19323659)
2009
22
PlayStation palmar hidradenitis. (19239462)
2009
23
Is granulomatous mastitis a localized form of hidradenitis suppurativa? (19527995)
2009
24
Hidradenitis suppurativa of the groin treated by radical excision and defect closure by medial thigh lift: aesthetic surgery meets reconstructive surgery. (18692456)
2009
25
Hidradenitis suppurativa: importance of early treatment; efficient treatment with electrosurgery. (18093196)
2008
26
Prevalence and factors associated with hidradenitis suppurativa: results from two case-control studies. (18674845)
2008
27
Neutrophilic eccrine hidradenitis masquerading as facial cellulitis. (17109994)
2007
28
Aminolevulinic acid photodynamic therapy for hidradenitis suppurativa. (17126743)
2007
29
Neutrophilic eccrine hidradenitis in non-small cell lung cancer. (17214722)
2007
30
Surgical treatment of hidradenitis suppurativa: case series and review of the literature. (16984573)
2006
31
A case of neutrophilic eccrine hidradenitis associated with streptococcal infectious endocarditis. (16484830)
2006
32
Dowling-Degos disease, hidradenitis suppurativa and arthritis in mother and daughter. (16681601)
2006
33
Experience with different treatment modules in hidradenitis suppuritiva: a study of 106 cases. (15789789)
2005
34
Treatment of long-standing extensive perianal hidradenitis suppurativa using double rotation plasty, V-Y plasty and free grafts. (12838364)
2004
35
Smoothbeam laser treatment may help improve hidradenitis suppurativa but not Hailey-Hailey disease. (15545102)
2004
36
Infectious eccrine hidradenitis caused by Nocardia. (14726895)
2004
37
Vulvar hidradenitis suppurativa. Immunohistochemical evaluation of apocrine and eccrine involvement. (12380447)
2002
38
Perirectal sinus tracks and fistulas caused by hidradenitis suppurativa. (11461896)
2001
39
Incidence of cancer among patients with hidradenitis suppurativa. (11405761)
2001
40
Neutrophilic eccrine hidradenitis unassociated with chemotherapy in a patient with acute myelogenous leukemia. (11328400)
2001
41
The clinical genetics of hidradenitis suppurativa revisited. (10809853)
2000
42
Marjolin's ulcer occurring in hidradenitis suppurativa. (10190470)
1999
43
Endocrine factors in pre- and postmenopausal women with hidradenitis suppurativa. (9205531)
1997
44
Dowling-Degos disease associated with hidradenitis suppurativa. (8959907)
1996
45
Anaerobic peptostreptococcal positive case of hidradenitis suppurativa. (20952918)
1995
46
Arthritis associated with hidradenitis suppurativa. (8311560)
1994
47
The clinical spectrum of the arthropathy associated with hidradenitis suppurativa and acne conglobata. (8496865)
1993
48
Androgen metabolism by isolated human axillary apocrine glands in hidradenitis suppurativa. (1954117)
1991
49
Perianal hidradenitis suppurativa. The Lahey Clinic experience. (2390907)
1990
50
Spondyloarthropathy associated with hidradenitis suppurative and acne conglobata. (6214980)
1982

Genetic Variations for Hidradenitis

Expression for genes affiliated with Hidradenitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hidradenitis

Search GEO for disease gene expression data for Hidradenitis.

Pathways for genes affiliated with Hidradenitis

Sources:
54Reactome, 60Tocris Bioscience, 52QIAGEN, 53R&D Systems, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Hidradenitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2PSENEN, NCSTN
210.1PSENEN, PSEN1
3
Hide members
10.0PSENEN, PSEN1, NCSTN
410.0PSENEN, PSEN1, NCSTN
5
Hide members
10.0PSEN1, PSENEN, NCSTN
6
Hide members
10.0PSEN1, PSENEN, NCSTN
710.0PSEN1, PSENEN, NCSTN
810.0PSEN1, NCSTN, PSENEN
910.0PSENEN, PSEN1, NCSTN
1010.0PSENEN, NCSTN, PSEN1
1110.0PSENEN, NCSTN, PSEN1
129.9KRT1, KRT14, KRT8
139.8PSEN1, PSENEN, NCSTN, SHH

Compounds for genes affiliated with Hidradenitis

Sources:
60Tocris Bioscience, 45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Hidradenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1mrk 5606010.5PSEN1, PSENEN
2jlk 66010.5PSEN1, PSENEN
3begacestat6010.4PSEN1, PSENEN
4l-685,4586010.4PSEN1, PSENEN
5dapt6010.4PSEN1, PSENEN
6estrogen4510.4TNFRSF1B, SRD5A1
7epitestosterone4510.2SHBG, SRD5A1
8enterolactone4510.2SRD5A1, SHBG
9formestane4510.2SRD5A1, SHBG
10hematoxylin4510.2KRT1, KRT14, KRT10, KRT8
11ment4510.2SRD5A1, SHBG
12toremifene45 1111.2CYP1A1, SHBG, TNFRSF1B
13dexamethasone45 50 29 1113.1TNFRSF1B, SHBG, CYP1A1
14androstenediol4510.1HSD17B13, SHBG, SRD5A1
15flutamide45 60 1112.1SHBG, CYP1A1, SRD5A1
16sildenafil45 50 29 11 2414.0SHBG, CYP1A1, SRD5A1
17isotretinoin45 1110.9KRT1, KRT14, KRT10, SRD5A1, PTHLH
18ketoconazole45 29 11 2412.9SHBG, CYP1A1, SRD5A1
19valine459.9PSEN1, CYP1A1, KRT1, PTHLH
20progestin459.8HSD17B13, SHBG, SRD5A1, PTHLH
21bromodeoxyuridine459.8PSEN1, KRT1, KRT14, KRT10, KRT8, PTHLH
22dehydroepiandrosterone sulfate459.8HSD17B13, SHBG, SRD5A1
23dihydrotestosterone45 29 11 2412.8HSD17B13, PIP, SHBG, SRD5A1
24progestins459.8HSD17B13, PIP, SHBG, SRD5A1
25estrone45 29 11 2412.8HSD17B13, SHBG, CYP1A1, SRD5A1
26norepinephrine45 11 2411.7PTHLH, CYP1A1, SHBG, PSEN1, TNFRSF1B
27paraffin459.7PIP, KRT1, KRT14, KRT10, KRT8, PTHLH
28retinoid459.7HSD17B13, SHBG, KRT1, KRT14, KRT10, KRT8
29calcitriol45 60 11 2412.7PTHLH, SRD5A1, KRT10, SHBG
30norgestimate45 1110.6SRD5A1, SHBG
31dhea459.6SRD5A1, SHBG, HSD17B13
32lysine459.6TNFRSF1B, PSEN1, RNASE7, KRT1, KRT14, PTHLH
33vitamin d459.6TNFRSF1B, SHBG, KRT14, KRT10, SRD5A1, PTHLH
34androstenedione45 2410.6HSD17B13, PIP, SHBG, CYP1A1, SRD5A1
35glucose459.4PTHLH, KRT8, KRT14, PSEN1, TNFRSF1B, HSD17B13
36lactate459.4HSD17B13, SHBG, CYP1A1, KRT8, PTHLH
37threonine459.4TNFRSF1B, PSEN1, KRT1, KRT14, KRT10, KRT8
38cisplatin45 50 60 1112.3TNFRSF1B, CYP1A1, KRT14, KRT8, PTHLH
39estradiol45 11 2411.3HSD17B13, PIP, SHBG, CYP1A1, SRD5A1, PTHLH
40cholesterol45 29 11 2412.3HSD17B13, TNFRSF1B, PSEN1, PSENEN, NCSTN, SHH
41arginine459.3TNFRSF1B, PSEN1, SHBG, CYP1A1, KRT1, KRT14
42tamoxifen45 50 29 1112.1HSD17B13, TNFRSF1B, PIP, SHBG, CYP1A1, KRT14
43tyrosine459.0TNFRSF1B, PSEN1, DSG2, KRT1, KRT14, KRT10
44lipid458.9HSD17B13, TNFRSF1B, PSEN1, PSENEN, NCSTN, SHBG
45steroid458.9HSD17B13, TNFRSF1B, PIP, SHBG, KRT1, KRT10
46serine458.8HSD17B13, TNFRSF1B, PSEN1, CYP1A1, KRT1, KRT14
47testosterone45 60 11 2411.8HSD17B13, TNFRSF1B, PIP, SHBG, CYP1A1, KRT1
48calcium45 50 11 2411.7TNFRSF1B, PSEN1, DSC1, DSC2, DSG2, KRT1
49progesterone45 60 29 11 2412.7PTHLH, HSD17B13, PIP, SHBG, CYP1A1, KRT1
50retinoic acid45 249.5TNFRSF1B, PSEN1, SHBG, DSC1, CYP1A1, KRT1

GO Terms for genes affiliated with Hidradenitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Hidradenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.9KRT14, KRT10, KRT8
2keratin filamentGO:0450959.7KRT1, KRT14, KRT10, KRT8
3desmosomeGO:0300579.6DSC1, DSC2, DSG2

Biological processes related to Hidradenitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1bundle of His cell to Purkinje myocyte communicationGO:08606910.3DSG2, DSC2
2amyloid precursor protein catabolic processGO:04298710.2NCSTN, PSENEN, PSEN1
3beta-amyloid metabolic processGO:05043510.2NCSTN, PSEN1
4Notch receptor processingGO:00722010.2PSEN1, PSENEN, NCSTN
5membrane protein ectodomain proteolysisGO:00650910.1NCSTN, PSENEN, PSEN1
6positive regulation of catalytic activityGO:04308510.1PSEN1, PSENEN, NCSTN
7epithelial cell proliferationGO:05067310.1PSEN1, NCSTN
8cell fate specificationGO:00170810.1SHH, PSEN1
9protein processingGO:01648510.0PTHLH, NCSTN, PSENEN, PSEN1
10dorsal/ventral neural tube patterningGO:02190410.0SHH, PSEN1
11membrane protein intracellular domain proteolysisGO:0312939.9NCSTN, PSENEN

Products for genes affiliated with Hidradenitis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Hidradenitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet