Aliases & Classifications for Hidradenitis

MalaCards integrated aliases for Hidradenitis:

Name: Hidradenitis 12 41 14 69
Hydradenitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2282
ICD9CM 34 705.83
MeSH 41 D016575
NCIt 46 C112190
UMLS 69 C0085160

Summaries for Hidradenitis

MalaCards based summary : Hidradenitis, also known as hydradenitis, is related to pyoderma gangrenosum and pyoderma. An important gene associated with Hidradenitis is NCSTN (Nicastrin), and among its related pathways/superpathways are Developmental Biology and Th17 cell differentiation. The drugs Adalimumab and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and testes, and related phenotype is craniofacial.

Wikipedia : 72 Hidradenitis is any disease in which the histologic abnormality is primarily an inflammatory infiltrate... more...

Related Diseases for Hidradenitis

Diseases related to Hidradenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 pyoderma gangrenosum 30.7 NOD2 TNF
2 pyoderma 30.7 NOD2 TNF
3 hidradenitis suppurativa 29.8 DSC2 DSG2 IL12RB1 IL17A KRT10 KRT14
4 arthritis 29.7 IL17A NOD2 TNF
5 spondyloarthropathy 1 29.5 IL17A NOD2 TNF
6 spondylitis 29.5 IL17A NOD2 TNF
7 dowling-degos disease 29.4 DSC2 KRT14 NCSTN PSENEN
8 colitis 29.4 IL17A NOD2 TNF
9 psoriasis 29.4 IL17A KRT10 KRT14 TNF
10 skin disease 29.4 KRT10 KRT14 TNF
11 pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 12.0
12 perifolliculitis capitis abscedens et suffodiens, familial 11.3
13 acne inversa, familial, 1 11.2
14 acne inversa, familial, 2, with or without dowling-degos disease 10.9
15 acne inversa, familial, 3 10.9
16 sebaceous gland disease 10.4 NCSTN PSENEN
17 ileocolitis 10.4 NOD2 TNF
18 granulomatous dermatitis 10.4 NOD2 TNF
19 crohn's colitis 10.3 NOD2 TNF
20 ocular toxoplasmosis 10.3 IL17A NOD2
21 inflammatory bowel disease 3 10.3 NOD2 TNF
22 rheumatoid lung disease 10.3 IL17A TNF
23 trichosporonosis 10.3 IL17A TNF
24 streptococcal meningitis 10.3 NOD2 TNF
25 blau syndrome 10.3 NOD2 TNF
26 central nervous system vasculitis 10.3 IL17A TNF
27 transverse myelitis 10.3 IL17A TNF
28 anal canal squamous cell carcinoma 10.3 NCSTN PSEN1 PSENEN
29 primary systemic mycosis 10.3 IL17A TNF
30 myelitis 10.3 IL17A TNF
31 stromal keratitis 10.2 IL17A TNF
32 panuveitis 10.2 IL17A TNF
33 squamous cell carcinoma 10.2
34 joint disorders 10.2 IL17A TNF
35 hypersensitivity reaction type iv disease 10.2 NOD2 TNF
36 basal cell carcinoma, infundibulocystic 10.2 KRT10 KRT14
37 filamentary keratitis 10.2 IL17A KRT10
38 crohn's disease 10.2
39 large cell acanthoma 10.2 KRT10 KRT14
40 epidermolysis bullosa simplex with mottled pigmentation 10.2 KRT10 KRT14
41 breast squamous cell carcinoma 10.2 KRT10 KRT14
42 striate palmoplantar keratoderma 10.2 KRT10 KRT14
43 cutaneous candidiasis 10.1 IL12RB1 IL17A
44 acute graft versus host disease 10.1 NOD2 TNF
45 epidermolysis bullosa simplex, dowling-meara type 10.1 KRT10 KRT14
46 inflammatory bowel disease 6 10.1 IL12RB1 NOD2
47 extrinsic cardiomyopathy 10.1 IL17A TNF
48 episodic pain syndrome, familial, 1 10.1
49 ileitis 10.1 IL17A NOD2 TNF
50 intestinal disease 10.1 IL17A NOD2 TNF

Graphical network of the top 20 diseases related to Hidradenitis:



Diseases related to Hidradenitis

Symptoms & Phenotypes for Hidradenitis

MGI Mouse Phenotypes related to Hidradenitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.02 IL17A KRT14 NCSTN PSEN1 TNF

Drugs & Therapeutics for Hidradenitis

Drugs for Hidradenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
2 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
3 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
4 Anesthetics Phase 4,Phase 1
5 Anti-Bacterial Agents Phase 3,Phase 2
6 Antibiotics, Antitubercular Phase 3
7
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
8
Infliximab Approved Phase 2 170277-31-3
9
Etanercept Approved, Investigational Phase 2 185243-69-0
10
Ustekinumab Approved, Investigational Phase 2 815610-63-0
11
Hydroxychloroquine Approved Phase 1, Phase 2 118-42-3 3652
12
Drospirenone Approved Phase 2 67392-87-4 68873
13
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
14
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
15 Anti-Infective Agents Phase 2,Phase 1
16 Immunosuppressive Agents Phase 2
17 Dermatologic Agents Phase 2
18 Hormone Antagonists Phase 2
19 Hormones Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
21 Analgesics Phase 2
22 Analgesics, Non-Narcotic Phase 2
23 Angiogenesis Inhibitors Phase 2
24 Angiogenesis Modulating Agents Phase 2
25 Anti-Inflammatory Agents, Non-Steroidal Phase 2
26 Peripheral Nervous System Agents Phase 2
27 Antibodies Phase 2,Phase 1,Early Phase 1
28 Antibodies, Monoclonal Phase 2,Phase 1,Early Phase 1
29 Immunoglobulins Phase 2,Phase 1,Early Phase 1
30 Interleukin 1 Receptor Antagonist Protein Phase 2
31 Gastrointestinal Agents Phase 2
32 Complement System Proteins Phase 2
33 Antimalarials Phase 1, Phase 2
34 Antiparasitic Agents Phase 1, Phase 2
35 Antiprotozoal Agents Phase 1, Phase 2
36 Contraceptive Agents Phase 2
37 Contraceptives, Oral Phase 2
38 diuretics Phase 2
39 Diuretics, Potassium Sparing Phase 2
40 Drospirenone and ethinyl estradiol combination Phase 2
41 Estradiol 17 beta-cypionate Phase 2
42 Estradiol 3-benzoate Phase 2
43 Estradiol valerate Phase 2 979-32-8
44 Estrogens Phase 2
45 Mineralocorticoid Receptor Antagonists Phase 2
46 Mineralocorticoids Phase 2
47 Natriuretic Agents Phase 2
48 Polyestradiol phosphate Phase 2
49
Phenol Approved, Experimental Phase 1 108-95-2 996
50 Pharmaceutical Solutions Phase 1

Interventional clinical trials:

(show top 50) (show all 55)

# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Humira (Adalimumab) for Hidradenitis Suppurativa (HS) Peri-Surgically (SHARPS Study) Recruiting NCT02808975 Phase 4 Adalimumab;Placebo
2 Cost-effectiveness of Adalimumab and Surgery vs Adalimumab in HS Not yet recruiting NCT03221621 Phase 4 Adalimumab Injection
3 Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa Completed NCT01468207 Phase 3
4 Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa Completed NCT01468233 Phase 3
5 Open-label Study of the Safety and Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa Completed NCT01635764 Phase 3
6 Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa Recruiting NCT02805595 Phase 3 23.4% Hypertonic saline;Saline
7 Open-label Study of Adalimumab in Japanese Subjects With Hidradenitis Suppurativa Active, not recruiting NCT02904902 Phase 3 Adalimumab
8 To Determine the Efficacy of a Laser Device for the Treatment of Hidradenitis Suppurativa Terminated NCT00367328 Phase 3
9 Single Center Study of Apremilast for the Treatment of Hidradenitis Suppurativa Completed NCT02695212 Phase 2 Apremilast
10 Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa Patients Completed NCT02421172 Phase 2
11 To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa Completed NCT00827996 Phase 2 adalimumab
12 Anakinra as a Treatment for Hydradenitis Suppurativa Completed NCT01516749 Phase 2 anakinra
13 Study to Assess the Safety and Efficacy of Infliximab to Treat Hidradenitis Suppurtativa Completed NCT00795574 Phase 2 infliximab;Placebo Comparator
14 Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa Completed NCT03001622 Phase 2
15 Etanercept in Hidradenitis Suppurativa Completed NCT00329823 Phase 2 Etanercept sc 50mg per week for 12 weeks
16 Anakinra in Hidradenitis Suppurativa Completed NCT01558375 Phase 2 Water for injection;Anakinra
17 MABp1 IN HIDRADENITIS SUPPURATIVA REFRACTORY TO ADALIMUMAB Completed NCT02643654 Phase 2 MABp1;Placebo
18 Short-term Safety, Efficacy and Mode of Action of Apremilast in Moderate Suppurative Hidradenitis Completed NCT03049267 Phase 2 Apremilast;Placebo Oral Tablet
19 A Proof of Concept Study to Evaluate the Effectiveness of Ustekinumab in Hidradenitis Suppurativa Completed NCT01704534 Phase 2 Ustekinumab
20 Etanercept for Treatment of Hidradenitis Completed NCT00107991 Phase 2 etanercept
21 Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa Completed NCT00918255 Phase 2 Placebo
22 A Study to Test the Efficacy, Safety and Pharmacokinetics of Bimekizumab in Subjects With Moderate to Severe Hidradenitis Suppurativa. Recruiting NCT03248531 Phase 2 Bimekizumab;Adalimumab
23 Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa Recruiting NCT03275870 Phase 1, Phase 2 Hydroxychloroquine
24 Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis Suppurativa Terminated NCT01838499 Phase 2
25 A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HS Terminated NCT00722800 Phase 2 drospirenone and ethinyl estradiol (YAZ);Placebo
26 Efficacy and Safety of Efalizumab in the Treatment of Moderate-Severe Hydradenitis Suppurativa Completed NCT00134134 Phase 1 efalizumab
27 Endoscopic Pilonidal Sinus Treatment With Additional Crystalized Phenol Completed NCT02277340 Phase 1
28 Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical Deroofing Unknown status NCT02163746
29 An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa. Unknown status NCT01818167 10% Benzoyl Peroxide Topical Body Wash;Provodine Topical Cream
30 Trial Comparing Efficacy of Treatments for Hidradenitis Suppurativa Unknown status NCT01063270 Clindamycin & Rifampin
31 Efficacy of Percutaneous Injection of Triamcinolone in the Treatment of Mammillary Fistula Unknown status NCT01315080
32 A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa. Completed NCT02781818 Triamcinolone Acetonide 10mg/mL;Triamcinolone Acetonide 40mg/mL;Normal Saline
33 Study on the Effect of NdYag Laser for the Treatment of Hidradenitis Suppurativa Completed NCT00494351
34 Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients Completed NCT02833909
35 Quality of Life After Wide Surgical Excision in Patients With Hidradenitis Suppurativa Completed NCT02593604
36 A Small Clinical Study: Photodynamic Therapy to Treat Hidradenitis Suppurativa Completed NCT00395187
37 Treatment of Hidradenitis Suppurativa Using Etanercept Completed NCT00949546 etanercept
38 Post-Marketing Surveillance of Adalimumab in Korean Hidradenitis Suppurativa Subjects Recruiting NCT03001115
39 Treatment of Hidradenitis Suppurativa With Eth 755nm Alexandrite Laser Recruiting NCT03054155
40 A National Registry For Patients With Hidradenitis Suppurativa Recruiting NCT03289585
41 Group Psychotherapy for Patients With Hidradenitis Suppurativa: Effects in Quality of Life Recruiting NCT02904408
42 Low Dose Radiotherapy for Advanced Hidradenitis Suppurativa Recruiting NCT03040804
43 Exploratory Trial Evaluating Cosentyx (Secukinumab) for Patients With Moderate-to-Severe Hidradenitis Suppurativa Recruiting NCT03099980 Early Phase 1
44 Canadian Humira Post Marketing Observational Epidemiological Study : Assessing Humira Real-life Effectiveness and Impact on HS Burden of Illness Recruiting NCT02896920
45 Impact of Hidradenitis Suppurativa on Quality of Life Functions Recruiting NCT03288337
46 Intense Pulsed Light Therapy for Hidrosadenitis Suppurativa Recruiting NCT03203122
47 The Ohio State University Dermatology Biorepository, Molecular Biology and Genetics of Hidradenitis Suppurativa Recruiting NCT03146676
48 Wound Etiology and Healing Study Recruiting NCT01352078
49 Chronic Inflammatory Disease, Lifestyle and Treatment Response Recruiting NCT03173144
50 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Hidradenitis

Cochrane evidence based reviews: hidradenitis

Genetic Tests for Hidradenitis

Anatomical Context for Hidradenitis

MalaCards organs/tissues related to Hidradenitis:

38
Neutrophil, Skin, Testes, Thyroid, Myeloid, Pituitary, Monocytes

Publications for Hidradenitis

Articles related to Hidradenitis:

(show top 50) (show all 769)
# Title Authors Year
1
Prevalence of Type II Diabetes Mellitus Among Patients with Hidradenitis Suppurativa in the United States. ( 29339240 )
2018
2
The effect of oral clindamycin and rifampicin combination therapy in patients with hidradenitis suppurativa in Singapore. ( 29403298 )
2018
3
Acquired lymphangioma circumscriptum of the genitals in an individual with chronic hidradenitis suppurativa. ( 29387752 )
2018
4
Complement activation in hidradenitis suppurativa: a new pathway of pathogenesis? ( 29405257 )
2018
5
Patients affected by Dent disease 2 could be predisposed to hidradenitis suppurativa. ( 29430722 )
2018
6
A case of pyoderma gangrenosum, acne, hidradenitis suppurativa (PASH) syndrome associated with diabetes mellitus type 1 treated with adalimumab. ( 29368847 )
2018
7
Comment on "Hidradenitis suppurativa in children treated with finasteride-A case series". ( 29356110 )
2018
8
The in-hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: a decade nationwide analysis from 2004 to 2014. ( 29431201 )
2018
9
A Novel Severity Assessment Scoring System for Hidradenitis Suppurativa. ( 29417136 )
2018
10
The immunological disease continuum of inflammation against self as an explanation for the lack of association between hidradenitis suppurativa and autoimmune thyroid disease. ( 29327479 )
2018
11
Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 2. ( 29363099 )
2018
12
Growing evidence for coronary artery disease risk factors in patients with severe hidradenitis suppurativa. ( 29357611 )
2018
13
Concurrent hidradenitis suppurativa and Dowling-Degos disease taken down a 'Notch'. ( 29441533 )
2018
14
Risk Factors for Hidradenitis Suppurativa in Patients with Inflammatory Bowel Disease. ( 29357084 )
2018
15
A case of Axillary Hidradenitis suppurativa treated with topical tacrolimus. ( 29368858 )
2018
16
Safety of Adalimumab Dosed Every Week and Every Other Week: Focus on Patients with Hidradenitis Suppurativa or Psoriasis. ( 29380251 )
2018
17
Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 1. ( 29355905 )
2018
18
Hidradenitis suppurativa is associated with polycystic ovary syndrome: a population-based analysis in the United States. ( 29378201 )
2018
19
Acne and hidradenitis suppurativa. ( 29380349 )
2018
20
Optimal Hidradenitis Suppurativa topical Treatment and Wound Care Management: A revised algorithm. ( 28952407 )
2017
21
Low Utilization of the Dermatology Ambulatory Encounter among Patients with Hidradenitis Suppurativa: A Population-Based Retrospective Cohort Analysis in the USA. ( 28954266 )
2017
22
Hidradenitis Suppurativa is Associated with Myocardial Infarction, but Not Stroke or Peripheral Arterial Disease of Lower Extremities. ( 28914960 )
2017
23
Proceeding report of the Symposium on Hidradenitis Suppurativa Advances (SHSA). ( 28898476 )
2017
24
Hidradenitis suppurativa treated with tetracycline in combination with colchicine: a prospective series of 20 patients. ( 28054351 )
2017
25
Polyclonal hyperglobulinemia and elevated acute phase reactants in hidradenitis suppurativa. ( 28886222 )
2017
26
Glucagon-like peptide-1 agonists for treatment of hidradenitis suppurativa. ( 28940285 )
2017
27
Neutrophilic Eccrine Hidradenitis in an HIV-Infected Patient. ( 28859744 )
2017
28
Prevalence and risk of inflammatory bowel disease in patients with hidradenitis suppurativa. ( 28089682 )
2017
29
Langerhans Cell Histiocytosis With Clinical and Histologic Features of Hidradenitis Suppurativa: Brief Report and Review. ( 28937439 )
2017
30
Body fat composition in hidradenitis suppurativa: a hospital-based cross-sectional study. ( 28084004 )
2017
31
Hidradenitis Suppurativa and Concomitant Down Syndrome: Literature Review of Other Associated Mucocutaneous Manifestations in Adults. ( 28859733 )
2017
32
Response to: 'Autoinflammatory disease damage index (ADDI): a possible newborn also in hidradenitis suppurativa daily practice' by Damiani et al. ( 28043999 )
2017
33
A phenotype combining hidradenitis suppurativa with Dowling-Degos disease caused by a founder mutation in PSENEN. ( 28922471 )
2017
34
SAPHO syndrome associated with hidradenitis suppurativa and pyoderma gangrenosum successfully treated with adalimumab and methotrexate: a case report and review of the literature. ( 28884797 )
2017
35
Quality of Life and Psychosocial Implications in Patients with Hidradenitis Suppurativa. ( 28052274 )
2017
36
Population Pharmacokinetics and Immunogenicity of Adalimumab in Adult Patients with Moderate-to-Severe Hidradenitis Suppurativa. ( 28066879 )
2017
37
Non-response to Interleukin-1 Antagonist Canakinumab in Two Patients with Refractory Pyoderma Gangrenosum and Hidradenitis Suppurativa. ( 29344326 )
2017
38
Mucinous adenocarcinoma in association with hidradenitis suppurativa. ( 28597923 )
2017
39
Uncovering burden disparity: A comparative analysis of the impact of moderate-to-severe psoriasis and hidradenitis suppurativa. ( 28917381 )
2017
40
Disseminate recurrent folliculitis as the presenting picture of hidradenitis suppurativa. ( 28838562 )
2017
41
Factors Contributing to Depression and Chronic Pain in Patients with Hidradenitis Suppurativa: Results from a Single-Center Retrospective Review. ( 28068657 )
2017
42
Successful Treatment of Severe Recalcitrant Hidradenitis Suppurativa with the Interleukin-17A Antibody Secukinumab. ( 28902952 )
2017
43
Interferon-gamma (IFN-I^) is Elevated in Wound Exudate from Hidradenitis Suppurativa. ( 27819528 )
2017
44
IBD LIVE Series-Case 8: Treatment Options for Refractory Esophageal Crohn's Disease and Hidradenitis Suppurativa. ( 28906288 )
2017
45
Novel POFUT1 mutation associated with hidradenitis suppurativa-Dowling Degos Disease firm up a role for Notch signalling in the pathogenesis of this disorder: reply from authors. ( 29274076 )
2017
46
A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report. ( 28868004 )
2017
47
Pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome in end-stage renal disease successfully treated with adalimumab. ( 29447652 )
2017
48
Remission of hidradenitis suppurativa after bariatric surgery. ( 28932789 )
2017
49
Novel POFUT1 mutation associated with hidradenitis suppurativa-Dowling-Degos disease firm up a role for Notch signalling in the pathogenesis of this disorder. ( 29274243 )
2017
50
Mucinous adenocarcinoma in association with hidradenitis suppurativa: a new example of isoscartopic response. ( 29271499 )
2017

Variations for Hidradenitis

Expression for Hidradenitis

Search GEO for disease gene expression data for Hidradenitis.

Pathways for Hidradenitis

Pathways related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 DSC2 DSG2 KRT10 KRT14 NCSTN PSENEN
2
Show member pathways
12.33 IL12RB1 IL17A NOD2 TNF
3
Show member pathways
12.21 DSC2 DSG2 KRT10 KRT14
4 11.98 NCSTN PSEN1 PSENEN
5
Show member pathways
11.94 NCSTN PSEN1 PSENEN
6 11.84 NCSTN PSEN1 PSENEN
7
Show member pathways
11.67 IL12RB1 IL17A TNF
8 11.51 IL12RB1 IL17A TNF
9
Show member pathways
11.4 NCSTN PSEN1 PSENEN
10 11.24 NCSTN PSEN1 PSENEN
11 11.06 IL17A TNF
12 10.99 NCSTN PSEN1 PSENEN
13 10.89 NOD2 TNF
14 10.49 NCSTN PSEN1 PSENEN
15 10.07 PSEN1 PSENEN
16 10.03 NCSTN PSEN1 PSENEN

GO Terms for Hidradenitis

Cellular components related to Hidradenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.56 DSG2 NOD2 PSEN1 TNF
2 desmosome GO:0030057 9.16 DSC2 DSG2
3 cornified envelope GO:0001533 9.13 DSC2 DSG2 KRT10
4 gamma-secretase complex GO:0070765 8.8 NCSTN PSEN1 PSENEN

Biological processes related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.86 NCSTN PSEN1 PSENEN TNF
2 Notch signaling pathway GO:0007219 9.74 NCSTN PSEN1 PSENEN
3 keratinization GO:0031424 9.73 DSC2 DSG2 KRT10 KRT14
4 cornification GO:0070268 9.71 DSC2 DSG2 KRT10 KRT14
5 positive regulation of catalytic activity GO:0043085 9.7 NCSTN PSEN1 PSENEN
6 ephrin receptor signaling pathway GO:0048013 9.69 NCSTN PSEN1 PSENEN
7 positive regulation of MAP kinase activity GO:0043406 9.65 NOD2 PSEN1 TNF
8 protein processing GO:0016485 9.63 NCSTN PSEN1 PSENEN
9 regulation of heart rate by cardiac conduction GO:0086091 9.61 DSC2 DSG2
10 positive regulation of interleukin-8 production GO:0032757 9.61 NOD2 TNF
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.6 NOD2 TNF
12 positive regulation of osteoclast differentiation GO:0045672 9.59 IL17A TNF
13 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.58 IL17A NOD2
14 amyloid-beta metabolic process GO:0050435 9.58 NCSTN PSEN1
15 epithelial cell proliferation GO:0050673 9.55 NCSTN PSEN1
16 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.54 DSC2 DSG2
17 membrane protein ectodomain proteolysis GO:0006509 9.54 NCSTN PSEN1 PSENEN
18 membrane protein intracellular domain proteolysis GO:0031293 9.5 NCSTN PSEN1 PSENEN
19 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.49 DSC2 DSG2
20 Notch receptor processing GO:0007220 9.43 NCSTN PSEN1 PSENEN
21 amyloid precursor protein metabolic process GO:0042982 9.33 NCSTN PSEN1 PSENEN
22 amyloid precursor protein catabolic process GO:0042987 9.13 NCSTN PSEN1 PSENEN
23 amyloid-beta formation GO:0034205 8.8 NCSTN PSEN1 PSENEN

Molecular functions related to Hidradenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.62 DSC2 DSG2

Sources for Hidradenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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