MCID: HDR003
MIFTS: 50

Hidradenitis malady

Summaries for Hidradenitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hidradenitis is any disease in which the histologic abnormality is primarily an inflammatory infiltrate... more...

MalaCards: Hidradenitis, also known as hydradenitis, is related to hidradenitis suppurativa and acne. An important gene associated with Hidradenitis is PSENEN (presenilin enhancer gamma secretase subunit), and among its related pathways are Signaling by NOTCH3 and Notch Pathway. The compounds l-685,458 and mrk 560 have been mentioned in the context of this disorder. Affiliated tissues include skin, myeloid and lymph node, and related mouse phenotypes are integument and craniofacial.

Aliases & Classifications for Hidradenitis

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

hidradenitis 8 60
hydradenitis 8


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Disease Ontology8 DOID:2282
ICD9CM27 705.83
MeSH34 D016575

Related Diseases for Hidradenitis

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17GeneCards, 18GeneDecks
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Diseases related to Hidradenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenitis suppurativa31.8NCSTN, PSENEN, TNFRSF1B
2acne31.0SHBG
3squamous cell carcinoma30.7TNFRSF1B, PIP, DSC2, DSG2, CYP1A1, KRT1
4psoriasis30.3TNFRSF1B, RNASE7, KRT1, KRT14, KRT10, NOD2
5arthropathy30.1NOD2, TNFRSF1B
6keratoacanthoma29.8KRT10
7keratosis29.8KRT1, KRT10
8skin disease29.8DSC1, KRT1, KRT14, KRT10, SRD5A1
9melanoma29.8SRD5A1, KRT8, KRT14, CYP1A1
10lung cancer29.8PIP, CYP1A1, KRT1, KRT14, PTHLH
11adenocarcinoma29.7PIP, CYP1A1, KRT1, KRT14, KRT10, KRT8
12crohn's disease10.5
13pyoderma gangrenosum10.3
14pyoderma10.3
15arthritis10.3
16cellulitis10.3
17leukemia10.2
18spondyloarthropathy10.2
19acute leukemia10.2
20keratitis10.2
21interstitial keratitis10.1
22vasculitis10.1
23urethritis10.0
24fox fordyce disease10.0
25pachyonychia congenita10.0
26reactive arthritis10.0
27verrucous carcinoma10.0
28amyloidosis10.0
29elephantiasis10.0
30hair disease10.0
31lymphedema10.0
32nephrotic syndrome10.0
33sebaceous gland disease10.0
34pyoderma gangrenosum - acne - suppurative hidradenitis10.0
35li-fraumeni syndrome10.0PIP
36ductal carcinoma in situ10.0KRT14
37basal cell carcinoma10.0SHH
38epidermolytic acanthoma10.0KRT1
39hypospadias10.0SRD5A1
40prostatitis10.0SRD5A1
41lichen planus10.0KRT1, KRT10
42hidrocystoma10.0PIP
43hypogonadism10.0SHBG
44meningioma10.0HSD17B13, KRT1
45ovarian cancer10.0KRT8
46psoriatic arthritis10.0TNFRSF1B
47ichthyosis, cyclic, with epidermolytic hyperkeratosis10.0KRT1, KRT10
48keratoderma10.0KRT14, KRT1
49alopecia10.0SHBG
50syringoma10.0KRT14, KRT1

Graphical network of the top 20 diseases related to Hidradenitis:



Diseases related to hidradenitis

Clinical Features for Hidradenitis

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Drugs & Therapeutics for Hidradenitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hidradenitis

Drug clinical trials:

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Search NIH Clinical Center for Hidradenitis

Search CenterWatch for Hidradenitis

Genetic Tests for Hidradenitis

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Anatomical Context for Hidradenitis

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32MalaCards
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MalaCards organs/tissues related to Hidradenitis:

32
Skin, Myeloid, Lymph node, Lung, Breast, Pituitary

Animal Models for Hidradenitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hidradenitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.8TNFRSF1B, PSEN1, KRT1, KRT14
2MP:00053829.2PSEN1, NCSTN, SHH, DSC1, KRT10, PTHLH
3MP:00053819.2TNFRSF1B, PSEN1, SHH, KRT14, KRT8, NOD2
4MP:00053919.1TNFRSF1B, PSEN1, NCSTN, SHH, DSC1, KRT14
5MP:00053848.7PSEN1, NCSTN, SHH, DSC1, DSG2, KRT14
6MP:00053978.6TNFRSF1B, PSEN1, NCSTN, SHH, CYP1A1, KRT8
7MP:00053878.4TNFRSF1B, PSEN1, NCSTN, SHH, DSC1, CYP1A1
8MP:00107688.3PTHLH, TNFRSF1B, PSEN1, PSENEN, NCSTN, SHH

Publications for Hidradenitis

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50PubMed
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Articles related to Hidradenitis:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
An open-label study of anakinra for the treatment ofA moderate to severe hidradenitis suppurativa. (24314876)
2013
2
The off-label treatment of severe hidradenitis suppurativa with TNF-I+ inhibitors: a systematic review. (22397574)
2013
3
Two-Stage Surgery for Hidradenitis Suppurativa: Staged Artificial Dermis and Skin Grafting. (24330271)
2013
4
Preliminary findings suggest hidradenitis suppurativa may be due to defective follicular support. (23320858)
2013
5
Hidradenitis suppurativa: a case study. (24180021)
2013
6
Analysis of patient claims data to determine the prevalence of hidradenitis suppurativa in the United States. (24124817)
2013
7
Radical surgical excision and use of lateral thoracic flap for intractable axillary hidradenitis suppurativa. (23233895)
2012
8
Hidradenitis suppurativa: surgical and other management techniques. (22092698)
2012
9
A comment on rapid progression of hidradenitis suppurativa in the lower leg of a patient with psoriasis vulgaris. (22511235)
2012
10
Hidradenitis suppurativa, eruptive melanocytic nevi, and keratosis pilaris-like eruption in a patient treated with vemurafenib. (23247496)
2012
11
Pott's disease with scrofuloderma and psoas abscess misdiagnosed and treated as hidradenitis suppurativa. (20536275)
2011
12
Histopathologic study of hidradenitis suppurativa following long-pulsed 1064-nm Nd:YAG laser treatment. (20855672)
2011
13
Confirmation by exome sequencing of the pathogenic role of NCSTN mutations in acne inversa (hidradenitis suppurativa). (21430701)
2011
14
Treatment of hidradenitis suppurativa with tumour necrosis factor-alpha inhibitors: An update on infliximab. (21103830)
2011
15
Biologic drugs for the treatment of hidradenitis suppurativa: an evidence-based review. (20510761)
2010
16
Surgical management of hidradenitis suppurativa. (20714346)
2010
17
Neutrophilic eccrine hidradenitis associated with decitabine. (20022375)
2010
18
Clinicopathological study of 13 cases of squamous cell carcinoma complicating hidradenitis suppurativa. (20029163)
2010
19
Infliximab therapy for patients with moderate to severe hidradenitis suppurativa: a randomized, double-blind, placebo-controlled crossover trial. (20115947)
2010
20
Hidradenitis suppurativa and Crohn's disease: two cases that support an association. (20976417)
2010
21
Lymph nodes in hidradenitis suppurativa. (19365106)
2009
22
Efficacy of adalimumab in recalcitrant hidradenitis suppurativa. (19153066)
2009
23
Pedicled gracilis myocutaneous flap for treatment of recalcitrant hidradenitis suppurativa of the groin and perineum. (19247231)
2009
24
Long-term successful adalimumab therapy in severe hidradenitis suppurativa. (19451504)
2009
25
Solving acne inversa (hidradenitis suppurativa) in Crohn disease with buried chip skin grafts. (19426627)
2009
26
Efficacy of Infliximab treatment in patients with severe Fistulizing Hidradenitis Suppurativa. (21172218)
2008
27
What causes hidradenitis suppurativa? (18400064)
2008
28
Hidradenitis suppurativa is acne inversa. (17343599)
2007
29
Chronic hidradenitis suppurativa and perianal mucinous adenocarcinoma. A case report. (17393769)
2007
30
Lack of association between CARD15 gene polymorphisms and hidradenitis suppurativa: a pilot study. (17911997)
2007
31
Neutrophilic eccrine hidradenitis with sclerodermoid change heralding the relapse of acute myelogenous leukemia: is this a paraneoplastic phenomenon? (17823528)
2007
32
Three fatal cases of squamous cell carcinoma arising in chronic perineal hidradenitis suppurativa. (17959012)
2007
33
The cutting edge. Severe hidradenitis suppurativa treated with adalimumab. (16982997)
2006
34
Etanercept: effective in the management of hidradenitis suppurativa. (16536817)
2006
35
Hidradenitis suppurativa treated with dapsone: A case series of five patients. (16971313)
2006
36
Hidradenitis suppurativa complicated by squamous cell carcinoma and paraneoplastic neuropathy. (15767822)
2005
37
Nephrotic syndrome associated with hidradenitis suppurativa. (15730062)
2005
38
Recurrent palmoplantar hidradenitis with exclusive palmar involvement and an association with trauma and exposure to aluminum dust. (14871322)
2004
39
Neutrophilic eccrine hidradenitis in a patient with BehAset's disease. (14609120)
2003
40
Immunohistochemical study of cytokeratins in hidradenitis suppurativa (acne inversa). (12025520)
2002
41
The natural history of hidradenitis suppurativa. (11305381)
2000
42
Hidradenitis suppurativa polyposa. (10982024)
2000
43
Forms of epithelial differentiation of draining sinus in acne inversa (hidradenitis suppurativa). (10468793)
1999
44
Vulval squamous cell carcinoma arising in chronic hidradenitis suppurativa. (10525388)
1999
45
The homogeneity of hidradenitis suppurativa lesions. A histological study of intra-individual variation. (9201239)
1997
46
Pathogenesis, clinical features and management of hidradenitis suppurativa. (9244084)
1997
47
The prevalence of hidradenitis suppurativa and its potential precursor lesions. (8708018)
1996
48
Scrotal elephantiasis associated with hidradenitis suppurativa. (8628808)
1996
49
Squamous cell carcinoma arising in hidradenitis suppurativa. (1918590)
1991
50
Hidradenitis suppurativa; its confusion with pilonidal disease and anal fistula. (18111693)
1949

Genetic Variations for Hidradenitis

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Expression for genes affiliated with Hidradenitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hidradenitis

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Pathways for genes affiliated with Hidradenitis

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53Reactome, 59Tocris Bioscience, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Hidradenitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2NCSTN, PSENEN
210.1PSEN1, PSENEN
310.0NCSTN, PSENEN, PSEN1
410.0NCSTN, PSENEN, PSEN1
510.0NCSTN, PSENEN, PSEN1
6
Hide members
10.0NCSTN, PSENEN, PSEN1
710.0NCSTN, PSENEN, PSEN1
8
Hide members
10.0PSEN1, PSENEN, NCSTN
9
Hide members
10.0PSEN1, PSENEN, NCSTN
1010.0PSEN1, PSENEN, NCSTN
1110.0PSEN1, PSENEN, NCSTN
129.9KRT8, KRT14, KRT1
139.8PSEN1, PSENEN, NCSTN, SHH

Compounds for genes affiliated with Hidradenitis

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59Tocris Bioscience, 44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Hidradenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1l-685,4585910.5PSENEN, PSEN1
2mrk 5605910.5PSENEN, PSEN1
3jlk 65910.4PSEN1, PSENEN
4dapt5910.4PSEN1, PSENEN
5begacestat5910.4PSENEN, PSEN1
6estrogen4410.4TNFRSF1B, SRD5A1
7epitestosterone4410.3SHBG, SRD5A1
8enterolactone4410.2SRD5A1, SHBG
9formestane4410.2SRD5A1, SHBG
10hematoxylin4410.2KRT14, KRT10, KRT8, KRT1
11ment4410.2SRD5A1, SHBG
12toremifene44 1111.2CYP1A1, SHBG, TNFRSF1B
13dexamethasone44 49 28 1113.1TNFRSF1B, SHBG, CYP1A1
14androstenediol4410.1SRD5A1, SHBG, HSD17B13
15flutamide44 59 1112.1SHBG, SRD5A1, CYP1A1
16sildenafil44 49 28 11 2414.0SRD5A1, CYP1A1, SHBG
17isotretinoin44 1110.9KRT1, KRT14, KRT10, SRD5A1, PTHLH
18ketoconazole44 28 11 2412.9SRD5A1, CYP1A1, SHBG
19valine449.9PSEN1, KRT1, PTHLH, CYP1A1
20progestin449.8SRD5A1, SHBG, HSD17B13, PTHLH
21bromodeoxyuridine449.8PTHLH, KRT8, KRT10, PSEN1, KRT14, KRT1
22dehydroepiandrosterone sulfate449.8HSD17B13, SHBG, SRD5A1
23dihydrotestosterone44 28 11 2412.8PIP, HSD17B13, SHBG, SRD5A1
24progestins449.8HSD17B13, PIP, SHBG, SRD5A1
25estrone44 28 11 2412.8HSD17B13, SHBG, CYP1A1, SRD5A1
26norepinephrine44 11 2411.7TNFRSF1B, PSEN1, SHBG, CYP1A1, PTHLH
27paraffin449.7KRT10, KRT8, PTHLH, KRT1, PIP, KRT14
28retinoid449.7KRT10, KRT1, SHBG, KRT14, HSD17B13, KRT8
29calcitriol44 59 11 2412.7PTHLH, SHBG, KRT10, SRD5A1
30norgestimate44 1110.6SRD5A1, SHBG
31dhea449.6HSD17B13, SRD5A1, SHBG
32lysine449.6KRT14, TNFRSF1B, PTHLH, KRT1, PSEN1, RNASE7
33vitamin d449.6KRT14, KRT10, TNFRSF1B, PTHLH, SRD5A1, SHBG
34androstenedione44 2410.6PIP, CYP1A1, SHBG, SRD5A1, HSD17B13
35glucose449.4PSEN1, TNFRSF1B, KRT14, HSD17B13, KRT8, PTHLH
36lactate449.4KRT8, PTHLH, HSD17B13, SHBG, CYP1A1
37threonine449.4KRT1, PSEN1, TNFRSF1B, KRT14, KRT10, KRT8
38cisplatin44 49 59 1112.3PTHLH, KRT8, KRT14, CYP1A1, TNFRSF1B
39estradiol44 11 2411.3CYP1A1, SRD5A1, PTHLH, PIP, SHBG, HSD17B13
40cholesterol44 28 11 2412.3PSEN1, HSD17B13, PSENEN, NCSTN, SHH, SHBG
41arginine449.3PTHLH, TNFRSF1B, SHBG, CYP1A1, KRT1, KRT14
42tamoxifen44 49 28 1112.1TNFRSF1B, PIP, SHBG, CYP1A1, KRT14, KRT8
43tyrosine449.0KRT8, PTHLH, KRT14, KRT10, PSEN1, DSG2
44lipid448.9NCSTN, KRT1, KRT8, TNFRSF1B, HSD17B13, PTHLH
45steroid448.9KRT8, HSD17B13, TNFRSF1B, PIP, SHBG, KRT1
46serine448.8HSD17B13, CYP1A1, TNFRSF1B, PTHLH, NOD2, KRT8
47testosterone44 59 11 2411.8HSD17B13, PTHLH, SRD5A1, KRT8, KRT1, SHBG
48calcium44 49 11 2411.7TNFRSF1B, DSC1, DSG2, DSC2, KRT8, KRT1
49progesterone44 59 28 11 2412.7KRT10, SHBG, CYP1A1, KRT1, PIP, HSD17B13
50retinoic acid44 249.5KRT14, TNFRSF1B, PTHLH, SRD5A1, KRT8, KRT10

GO Terms for genes affiliated with Hidradenitis

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16Gene Ontology
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Cellular components related to Hidradenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.9KRT8, KRT10, KRT14
2keratin filamentGO:0450959.7KRT8, KRT10, KRT14, KRT1
3desmosomeGO:0300579.6DSC1, DSC2, DSG2

Biological processes related to Hidradenitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1bundle of His cell to Purkinje myocyte communicationGO:08606910.3DSG2, DSC2
2amyloid precursor protein catabolic processGO:04298710.2NCSTN, PSENEN, PSEN1
3beta-amyloid metabolic processGO:05043510.2NCSTN, PSEN1
4Notch receptor processingGO:00722010.2PSEN1, PSENEN, NCSTN
5membrane protein ectodomain proteolysisGO:00650910.1NCSTN, PSENEN, PSEN1
6positive regulation of catalytic activityGO:04308510.1PSEN1, PSENEN, NCSTN
7epithelial cell proliferationGO:05067310.1PSEN1, NCSTN
8cell fate specificationGO:00170810.1SHH, PSEN1
9protein processingGO:01648510.0PTHLH, NCSTN, PSENEN, PSEN1
10dorsal/ventral neural tube patterningGO:02190410.0SHH, PSEN1
11membrane protein intracellular domain proteolysisGO:0312939.9NCSTN, PSENEN

Products for genes affiliated with Hidradenitis

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  • Antibodies
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Sources for Hidradenitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet