MCID: HDR002
MIFTS: 51

Hidradenitis Suppurativa malady

Categories: Rare diseases, Skin diseases, Genetic diseases

Aliases & Classifications for Hidradenitis Suppurativa

Aliases & Descriptions for Hidradenitis Suppurativa:

Name: Hidradenitis Suppurativa 12 50 25 41 42 14 69
Acne Inversa 50 25
Hidradenitides, Suppurative 25
Suppurative Hidradenitides 25
Hidradenitis, Suppurative 25
Suppurative Hidradenitis 25
Acne Inversa, Familial 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2280
ICD10 33 L73.2
MeSH 42 D017497
UMLS 69 C0162836

Summaries for Hidradenitis Suppurativa

NIH Rare Diseases : 50 hidradenitis suppurativa (hs) is a chronic skin disease characterized by recurrent, painful, boil-like lumps (nodules) under the skin. hs affects the areas around skin folds (e.g., armpits, groin, and breasts) and where apocrine glands (a form of sweat gland) and hair follicles are found. it is not contagious, but it is recurrent. it typically manifests as a single boil-like, pus-filled abscess or hard sebaceous lumps (lumps composed of sebum, or oil, which is excreted by the sebacous glands associated with hair follicles) and may progress to painful, deep-seated, inflamed clusters of lesions with chronic seepage involving significant scarring. in most cases, the cause of hs is unknown. it is likely that it results from a combination of genetic and environmental factors. some cases of hs have been associated with specific genes, including ncstn, psen1, and psenen.  last updated: 3/6/2015

MalaCards based summary : Hidradenitis Suppurativa, also known as acne inversa, is related to squamous cell carcinoma and pyoderma gangrenosum-acne-suppurative hidradenitis syndrome, and has symptoms including exanthema and pruritus. An important gene associated with Hidradenitis Suppurativa is NCSTN (Nicastrin), and among its related pathways/superpathways are Developmental Biology and Th17 cell differentiation. The drugs Adalimumab and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and neutrophil, and related phenotypes are craniofacial and digestive/alimentary

Genetics Home Reference : 25 Hidradenitis suppurativa, also known as acne inversa, is a chronic skin disease characterized by recurrent boil-like lumps (nodules) under the skin. The nodules become inflamed and painful. They tend to break open (rupture), causing abscesses that drain fluid and pus. As the abscesses heal, they produce significant scarring of the skin.

MedlinePlus : 41 hidradenitis suppurativa (hs) is a chronic skin disease. it can occur in one or multiple areas of your body. hs usually develops in your armpits, groin, and anal area. it causes long-term skin inflammation and can be painful. symptoms include blackheads and red, tender bumps, called abscesses. the abscesses get bigger, break open, and leak pus tunnels that form under the skin between abscesses scarring no one knows what causes hs. it is more common in women, african americans, and people who have had acne. it usually starts after the teenage years. treatments include antibiotics, anti-inflammatory medicines, and sometimes surgery. losing weight or wearing looser clothing may help some patients avoid skin irritation.

Wikipedia : 71 Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic skin disease characterized by... more...

Related Diseases for Hidradenitis Suppurativa

Diseases related to Hidradenitis Suppurativa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
id Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 30.8 KRT10 KRT14
2 pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 12.0
3 acne inversa, familial, 1 11.3
4 hidradenitis 11.2
5 perifolliculitis capitis abscedens et suffodiens, familial 11.1
6 acne inversa, familial, 3 11.1
7 acne inversa, familial, 2 11.1
8 acne 10.7
9 crohn's disease 10.4
10 pyoderma 10.3
11 pyoderma gangrenosum 10.3
12 arthritis 10.2
13 dermatosis papulosa nigra 10.2 NOD2 TNF
14 amyotrophic lateral sclerosis type 5 10.2 NOD2 TNF
15 psoriasis 10.2
16 dowling-degos disease 10.2
17 psoriatic arthritis 10.2 NOD2 TNF
18 stomach carcinoma in situ 10.2 NCSTN PSENEN
19 odontogenic myxoma 10.2 IL17A NOD2
20 spondyloarthropathy 10.2
21 dermatitis herpetiformis 10.2 IL17A TNF
22 amyotrophic lateral sclerosis type 14 10.2 NOD2 TNF
23 intermediate malignant teratoma 10.2 NCSTN PSEN1 PSENEN
24 aniseikonia 10.1 IL17A TNF
25 meier-gorlin syndrome 3 10.1 NOD2 TNF
26 nemaline myopathy 1, autosomal dominant or recessive 10.1 NCSTN PSENEN TNF
27 keratitis 10.1
28 inflammatory bowel disease 10.1
29 cellulitis 10.1
30 elephantiasis 10.1
31 scleroperikeratitis 10.1 KRT14 NCSTN PSENEN
32 trichomalacia 10.1 IL17A TNF
33 ebola hemorrhagic fever 10.1 KRT10 KRT14
34 anal margin basal cell carcinoma 10.1 KRT10 KRT14
35 mixed cell adenoma 10.1 KRT10 KRT14
36 interstitial keratitis 10.1
37 arthropathy 10.1
38 lymphedema 10.1
39 histiocytoma 10.1 NOD2 TNF
40 parkinson disease 11 10.1 IL17A NOD2 TNF
41 gastric dilatation 10.0 IL17A TNF
42 dowling-degos disease 1 10.0 KRT10 KRT14
43 crohn's colitis 10.0 IL17A NOD2 TNF
44 celiac disease 10.0 IL17A NOD2 TNF
45 endobronchial leiomyoma 10.0 IL17A NOD2 TNF
46 uterine ligament clear cell adenocarcinoma 10.0 IL17A NOD2 TNF
47 esophageal candidiasis 10.0 IL17A NOD2 TNF
48 molybdenum cofactor deficiency a 10.0 IL17A NOD2 TNF
49 childhood malignant hemangiopericytoma 10.0 IL17A NOD2 TNF
50 thymus mucoepidermoid carcinoma 10.0 IL17A KRT10

Graphical network of the top 20 diseases related to Hidradenitis Suppurativa:



Diseases related to Hidradenitis Suppurativa

Symptoms & Phenotypes for Hidradenitis Suppurativa

UMLS symptoms related to Hidradenitis Suppurativa:


exanthema, pruritus

MGI Mouse Phenotypes related to Hidradenitis Suppurativa:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.65 IL17A KRT14 NCSTN PSEN1 TNF
2 digestive/alimentary MP:0005381 9.55 IL17A KRT14 NOD2 PSEN1 TNF
3 hematopoietic system MP:0005397 9.5 TNF IL12RB1 IL17A KRT14 NCSTN NOD2
4 immune system MP:0005387 9.17 IL12RB1 IL17A KRT14 NCSTN NOD2 PSEN1

Drugs & Therapeutics for Hidradenitis Suppurativa

Drugs for Hidradenitis Suppurativa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
2 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
3 Antirheumatic Agents Phase 4,Phase 3,Phase 2
4 Anti-Bacterial Agents Phase 3,Phase 2
5 Antibiotics, Antitubercular Phase 3
6
Etanercept Approved, Investigational Phase 2 185243-69-0
7
Ustekinumab Approved, Investigational Phase 2 815610-63-0
8
Infliximab Approved Phase 2 170277-31-3
9
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
10
Drospirenone Approved Phase 2 67392-87-4 68873
11
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757 53477783
12
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
13 Immunosuppressive Agents Phase 2
14 Dermatologic Agents Phase 2
15 Anti-Infective Agents Phase 2,Phase 1
16 Hormone Antagonists Phase 2
17 Hormones Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
19 Analgesics Phase 2
20 Analgesics, Non-Narcotic Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 2
22 Gastrointestinal Agents Phase 2
23 Peripheral Nervous System Agents Phase 2
24 Antibodies Phase 2,Phase 1,Early Phase 1
25 Antibodies, Monoclonal Phase 2,Phase 1,Early Phase 1
26 Immunoglobulins Phase 2,Phase 1,Early Phase 1
27 Interleukin 1 Receptor Antagonist Protein Phase 2
28 Angiogenesis Inhibitors Phase 2
29 Angiogenesis Modulating Agents Phase 2
30 Complement System Proteins Phase 2
31 Contraceptive Agents Phase 2
32 Contraceptives, Oral Phase 2
33 diuretics Phase 2
34 Diuretics, Potassium Sparing Phase 2
35 Drospirenone and ethinyl estradiol combination Phase 2
36 Estradiol 17 beta-cypionate Phase 2
37 Estradiol 3-benzoate Phase 2
38 Estradiol valerate Phase 2 979-32-8
39 Estrogens Phase 2
40 Mineralocorticoid Receptor Antagonists Phase 2
41 Mineralocorticoids Phase 2
42 Natriuretic Agents Phase 2
43 Polyestradiol phosphate Phase 2
44
Phenol Approved, Experimental Phase 1 108-95-2 996
45 Pharmaceutical Solutions Phase 1
46 Anesthetics Phase 1
47 Anti-Infective Agents, Local Phase 1
48 Disinfectants Phase 1
49
Benzoyl peroxide Approved 94-36-0 7187
50
Clindamycin Approved, Vet_approved 18323-44-9 29029

Interventional clinical trials:

(show all 46)
id Name Status NCT ID Phase
1 Safety and Efficacy of Humira (Adalimumab) for Hidradenitis Suppurativa (HS) Peri-Surgically (SHARPS Study) Recruiting NCT02808975 Phase 4
2 Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa Completed NCT01468207 Phase 3
3 Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa Completed NCT01468233 Phase 3
4 Open-label Study of the Safety and Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa Completed NCT01635764 Phase 3
5 Open-label Study of Adalimumab in Japanese Subjects With Hidradenitis Suppurativa Recruiting NCT02904902 Phase 3
6 Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa Recruiting NCT02805595 Phase 3
7 To Determine the Efficacy of a Laser Device for the Treatment of Hidradenitis Suppurativa Terminated NCT00367328 Phase 3
8 To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa Completed NCT00827996 Phase 2
9 Etanercept in Hidradenitis Suppurativa Completed NCT00329823 Phase 2
10 Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa Patients Completed NCT02421172 Phase 2
11 Anakinra as a Treatment for Hydradenitis Suppurativa Completed NCT01516749 Phase 2
12 Anakinra in Hidradenitis Suppurativa Completed NCT01558375 Phase 2
13 A Proof of Concept Study to Evaluate the Effectiveness of Ustekinumab in Hidradenitis Suppurativa Completed NCT01704534 Phase 2
14 Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa Completed NCT00918255 Phase 2
15 MABp1 IN HIDRADENITIS SUPPURATIVA REFRACTORY TO ADALIMUMAB Completed NCT02643654 Phase 2
16 Study to Assess the Safety and Efficacy of Infliximab to Treat Hidradenitis Suppurtativa Completed NCT00795574 Phase 2
17 Etanercept for Treatment of Hidradenitis Completed NCT00107991 Phase 2
18 Single Center Study of Apremilast for the Treatment of Hidradenitis Suppurativa Recruiting NCT02695212 Phase 2
19 Short-term Safety, Efficacy and Mode of Action of Apremilast in Moderate Suppurative Hidradenitis Recruiting NCT03049267 Phase 2
20 Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa Active, not recruiting NCT03001622 Phase 2
21 Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis Suppurativa Terminated NCT01838499 Phase 2
22 A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HS Terminated NCT00722800 Phase 2
23 Efficacy and Safety of Efalizumab in the Treatment of Moderate-Severe Hydradenitis Suppurativa Completed NCT00134134 Phase 1
24 Endoscopic Pilonidal Sinus Treatment With Additional Crystalized Phenol Completed NCT02277340 Phase 1
25 An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa. Unknown status NCT01818167
26 Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical Deroofing Unknown status NCT02163746
27 Trial Comparing Efficacy of Treatments for Hidradenitis Suppurativa Unknown status NCT01063270
28 Efficacy of Percutaneous Injection of Triamcinolone in the Treatment of Mammillary Fistula Unknown status NCT01315080
29 Study on the Effect of NdYag Laser for the Treatment of Hidradenitis Suppurativa Completed NCT00494351
30 A Small Clinical Study: Photodynamic Therapy to Treat Hidradenitis Suppurativa Completed NCT00395187
31 Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients Completed NCT02833909
32 Treatment of Hidradenitis Suppurativa Using Etanercept Completed NCT00949546
33 Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients - a Multi cOuNtry studY in Real Life Setting Recruiting NCT02786576
34 Post-Marketing Surveillance of Adalimumab in Korean Hidradenitis Suppurativa Subjects Recruiting NCT03001115
35 A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa. Recruiting NCT02781818
36 Low Dose Radiotherapy for Advanced Hidradenitis Suppurativa Recruiting NCT03040804
37 Post Marketing Observational Study (PMOS) to Assess Quality of Life in Swedish Hidradenitis Suppurativa (HS) Patients Recruiting NCT02739828
38 Exploratory Trial Evaluating Cosentyx (Secukinumab) for Patients With Moderate-to-Severe Hidradenitis Suppurativa Recruiting NCT03099980 Early Phase 1
39 Pilot Study on Botulinum Toxin B as Treatment for Hidradenitis Suppurativa Recruiting NCT03103074
40 Canadian Humira Post Marketing Observational Epidemiological Study : Assessing Humira Real-life Effectiveness and Impact on HS Burden of Illness Recruiting NCT02896920
41 Treatment of Hidradenitis Suppurativa With Eth 755nm Alexandrite Laser Recruiting NCT03054155
42 The Ohio State University Dermatology Biorepository, Molecular Biology and Genetics of Hidradenitis Suppurativa Recruiting NCT03146676
43 Group Psychotherapy for Patients With Hidradenitis Suppurativa: Effects in Quality of Life Recruiting NCT02904408
44 Quality of Life After Wide Surgical Excision in Patients With Hidradenitis Suppurativa Enrolling by invitation NCT02593604
45 Patients With Hidradenitis vs Patients With Psoriasis: Psychological Impact Not yet recruiting NCT02999698
46 Chronic Inflammatory Disease, Lifestyle and Treatment Response Not yet recruiting NCT03173144

Search NIH Clinical Center for Hidradenitis Suppurativa

Cochrane evidence based reviews: hidradenitis suppurativa

Genetic Tests for Hidradenitis Suppurativa

Anatomical Context for Hidradenitis Suppurativa

MalaCards organs/tissues related to Hidradenitis Suppurativa:

39
Skin, Breast, Neutrophil, Endothelial, Myeloid, Lymph Node, Pituitary

Publications for Hidradenitis Suppurativa

Articles related to Hidradenitis Suppurativa:

(show top 50) (show all 631)
id Title Authors Year
1
Factors Contributing to Depression and Chronic Pain in Patients with Hidradenitis Suppurativa: Results from a Single-Center Retrospective Review. ( 28068657 )
2017
2
Interferon-gamma (IFN-I^) is Elevated in Wound Exudate from Hidradenitis Suppurativa. ( 27819528 )
2017
3
Quality of Life and Psychosocial Implications in Patients with Hidradenitis Suppurativa. ( 28052274 )
2017
4
Weekly adalimumab significantly reduces the number of abscesses and inflammatory nodules in patients with moderate to severe hidradenitis suppurativa. ( 28053204 )
2017
5
Response to: 'Autoinflammatory disease damage index (ADDI): a possible newborn also in hidradenitis suppurativa daily practice' by Damiani et al. ( 28043999 )
2017
6
Prevalence and risk of inflammatory bowel disease in patients with hidradenitis suppurativa. ( 28089682 )
2017
7
Hidradenitis suppurativa treated with tetracycline in combination with colchicine: a prospective series of 20 patients. ( 28054351 )
2017
8
Body fat composition in hidradenitis suppurativa: a hospital-based cross-sectional study. ( 28084004 )
2017
9
Population Pharmacokinetics and Immunogenicity of Adalimumab in Adult Patients with Moderate-to-Severe Hidradenitis Suppurativa. ( 28066879 )
2017
10
Bacterial Biofilm in Chronic Lesions of Hidradenitis Suppurativa. ( 27564400 )
2016
11
Adalimumab: A Review in Hidradenitis Suppurativa. ( 27665300 )
2016
12
Clinical experience of the use of adalimumab in the management of hidradenitis suppurativa. Comparison of response rates with Crohn disease. ( 28081769 )
2016
13
Accelerated wound healing after wide excisions in Hidradenitis Suppurativa using autologous split-thickness skin grafting and platelet-rich plasma. ( 27611792 )
2016
14
Intrinsic defect in keratinocyte function leads to inflammation in Hidradenitis suppurativa. ( 27206704 )
2016
15
Reply to Revuz' Letter Entitled 'Hidradenitis Suppurativa: Terminology'. ( 27159977 )
2016
16
Reduction in pain scores and improvement in depressive symptoms in patients with hidradenitis suppurativa treated with adalimumab in a phase 2, randomized, placebo-controlled trial. ( 27136622 )
2016
17
When inflammation shifts to malignancy: extensive squamous cell carcinoma in a female hidradenitis suppurativa/acne inversa patient. ( 28036145 )
2016
18
Management of hidradenitis suppurativa. ( 27585997 )
2016
19
Hidradenitis suppurativa and perianal Crohn disease: differential diagnosis. ( 28081767 )
2016
20
Combination of oral zinc gluconate and topical triclosan: An anti-inflammatory treatment modality for initial hidradenitis suppurativa. ( 27554338 )
2016
21
Qualitative study shows disease damage matters to patients with hidradenitis suppurativa. ( 27185436 )
2016
22
Hidradenitis suppurativa: A disease of infundibular epidermis, rather than pilosebaceous units? ( 27542326 )
2016
23
Diagnoses of Hidradenitis Suppurativa in the United States, 1979-2012. ( 27171648 )
2016
24
Oral clindamycin and rifampicin in the treatment of hidradenitis suppurativa-acne inversa: can some factors influence the response to the treatment? ( 27068603 )
2016
25
Hidradenitis suppurativa patients have no increased risk of Alzheimer's disease. ( 27639074 )
2016
26
The Hidradenitis suppurativa patient journey in Italy: current status, unmet needs and opportunities. ( 27136185 )
2016
27
Ustekinumab, another biologic with potential to help patients with hidradenitis suppurativa? ( 27115586 )
2016
28
High Copy Numbers of Beta-Defensin Cluster on 8p23.1 Confer Genetic Susceptibility and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa. ( 27164300 )
2016
29
Hidradenitis suppurativa (HS) and Down syndrome (DS): Increased prevalence and a younger age of hidradenitis symptom onset. ( 27543219 )
2016
30
Epidemiological, clinical and therapeutic aspects in special situations: hidradenitis suppurativa in paediatric patients. ( 28081770 )
2016
31
Management of hidradenitis suppurativa in pregnancy. ( 28040373 )
2016
32
Primary Cutaneous Plasmacytosis: Masquerading as Hidradenitis Suppurativa. ( 27057027 )
2016
33
Hidradenitis suppurativa-acne inversa-like lesions complicating naevus comedonicus: second case supporting the mechanical stress as a triggering factor. ( 27176082 )
2016
34
Recalcitrant Hidradenitis Suppurativa: An Investigation of Demographics, Surgical Management, Bacterial Isolates, Pharmacologic Intervention, and Patient-reported Health Outcomes. ( 27097631 )
2016
35
Regional variation of Hidradenitis suppurativa in the Norwegian Patient Registry (NPR) during 5 years period may describe professional awareness of the disease not changes in prevalens. ( 27543427 )
2016
36
Hidradenitis suppurativa is not associated with the metabolic syndrome based on body type: A cross-sectional study. ( 27608328 )
2016
37
Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: Implications for treatment with anti-IL-17 agents. ( 28041632 )
2016
38
Hidradenitis Suppurativa and Inflammatory Bowel Disease: A Cross-Sectional Study of 3,207 Patients. ( 27094593 )
2016
39
Interventions for hidradenitis suppurativa: an important step towards evidence-based medicine. ( 27206354 )
2016
40
What Heals Hidradenitis Suppurativa: Surgery, Immunosuppression, or Both? ( 27556765 )
2016
41
Discussion: What Heals Hidradenitis Suppurativa: Surgery, Immunosuppression, or Both? ( 27556766 )
2016
42
Hidradenitis Suppurativa and the Association With Hematological Malignancies: A Review of 2 Cases. ( 27573126 )
2016
43
Management of patients with hidradenitis suppurativa. ( 28081768 )
2016
44
Phenotypic Characterization of Patients with Hidradenitis Suppurativa. ( 27576734 )
2016
45
Management of Hidradenitis Suppurativa in Patients with Metabolic Comorbidities. ( 27081259 )
2016
46
Hidradenitis Suppurativa: Terminology. ( 27161332 )
2016
47
Successful treatment of widespread chronic gluteal hidradenitis suppurativa with combination of recycled skin graft and negative-pressure wound therapy. ( 27651126 )
2016
48
Therapeutic approach to Crohn disease: possible parallels with hidradenitis suppurativa. ( 28081765 )
2016
49
Mammalian target of rapamycin, insulin resistance and hidradenitis suppurativa: a possible metabolic loop. ( 26299257 )
2016
50
Inflammation induced changes in the expression levels of components of the microRNA maturation machinery Drosha, Dicer, Drosha co-factor DGRC8 and Exportin-5 in inflammatory lesions of hidradenitis suppurativa patients. ( 26917346 )
2016

Variations for Hidradenitis Suppurativa

Expression for Hidradenitis Suppurativa

Search GEO for disease gene expression data for Hidradenitis Suppurativa.

Pathways for Hidradenitis Suppurativa

Pathways related to Hidradenitis Suppurativa according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 DSC2 KRT10 KRT14 NCSTN PSENEN TNF
2
Show member pathways
12.27 IL12RB1 IL17A NOD2 TNF
3 11.97 NCSTN PSEN1 PSENEN
4
Show member pathways
11.93 NCSTN PSEN1 PSENEN
5 11.82 NCSTN PSEN1 PSENEN
6
Show member pathways
11.66 IL12RB1 IL17A TNF
7 11.48 IL12RB1 IL17A TNF
8
Show member pathways
11.36 NCSTN PSEN1 PSENEN
9 11.2 NCSTN PSEN1 PSENEN
10 11.05 IL17A TNF
11 10.99 NCSTN PSEN1 PSENEN
12 10.87 NOD2 TNF
13 10.55 NCSTN PSEN1 PSENEN
14 10.03 NCSTN PSEN1 PSENEN
15 10.02 PSEN1 PSENEN

GO Terms for Hidradenitis Suppurativa

Cellular components related to Hidradenitis Suppurativa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 IL12RB1 IL17A TNF
2 gamma-secretase complex GO:0070765 8.8 NCSTN PSEN1 PSENEN

Biological processes related to Hidradenitis Suppurativa according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.75 DSC2 KRT10 KRT14
2 positive regulation of apoptotic process GO:0043065 9.73 NCSTN PSEN1 PSENEN TNF
3 Notch signaling pathway GO:0007219 9.67 NCSTN PSEN1 PSENEN
4 cornification GO:0070268 9.65 DSC2 KRT10 KRT14
5 positive regulation of interferon-gamma production GO:0032729 9.59 IL12RB1 TNF
6 positive regulation of interleukin-6 production GO:0032755 9.58 NOD2 TNF
7 positive regulation of catalytic activity GO:0043085 9.58 NCSTN PSEN1 PSENEN
8 positive regulation of interleukin-8 production GO:0032757 9.57 NOD2 TNF
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.56 NOD2 TNF
10 positive regulation of osteoclast differentiation GO:0045672 9.55 IL17A TNF
11 membrane protein intracellular domain proteolysis GO:0031293 9.54 NCSTN PSENEN
12 protein processing GO:0016485 9.54 NCSTN PSEN1 PSENEN
13 beta-amyloid metabolic process GO:0050435 9.52 NCSTN PSEN1
14 epithelial cell proliferation GO:0050673 9.51 NCSTN PSEN1
15 membrane protein ectodomain proteolysis GO:0006509 9.5 NCSTN PSEN1 PSENEN
16 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.46 IL17A NOD2
17 Notch receptor processing GO:0007220 9.43 NCSTN PSEN1 PSENEN
18 amyloid precursor protein metabolic process GO:0042982 9.33 NCSTN PSEN1 PSENEN
19 amyloid precursor protein catabolic process GO:0042987 9.13 NCSTN PSEN1 PSENEN
20 beta-amyloid formation GO:0034205 8.8 NCSTN PSEN1 PSENEN

Sources for Hidradenitis Suppurativa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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