MCID: HDR002
MIFTS: 51

Hidradenitis Suppurativa

Categories: Rare diseases, Skin diseases, Genetic diseases

Aliases & Classifications for Hidradenitis Suppurativa

MalaCards integrated aliases for Hidradenitis Suppurativa:

Name: Hidradenitis Suppurativa 12 50 25 41 42 14 69
Acne Inversa 50 25
Hidradenitides, Suppurative 25
Suppurative Hidradenitides 25
Hidradenitis, Suppurative 25
Suppurative Hidradenitis 25
Acne Inversa, Familial 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2280
ICD10 33 L73.2
MeSH 42 D017497
UMLS 69 C0162836

Summaries for Hidradenitis Suppurativa

NIH Rare Diseases : 50 hidradenitis suppurativa (hs) is an inflammatory, chronic skin disease characterized by recurrent, painful, boil-like lumps (nodules) under the skin. hs affects the areas around skin folds (e.g., armpits, groin, and breasts) and where apocrine glands (a form of sweat gland) and hair follicles are found. it is not contagious. it typically manifests as a single pocket of pus (abscess) or hard, sebaceous lumps (lumps composed of sebum, or oil, which is excreted by the sebacous glands associated with hair follicles). it may progress to painful, deep-seated, inflamed clusters of lesions with chronic seepage involving significant scarring. in most cases, the cause of hs is unknown. it is likely that it results from a combination of genetic and environmental factors. some cases of hs have been associated with specific genes, including ncstn, psen1, and psenen. last updated: 3/6/2015

MalaCards based summary : Hidradenitis Suppurativa, also known as acne inversa, is related to neuropathy and pyoderma gangrenosum-acne-suppurative hidradenitis syndrome, and has symptoms including exanthema and pruritus. An important gene associated with Hidradenitis Suppurativa is NCSTN (Nicastrin), and among its related pathways/superpathways are Developmental Biology and Th17 cell differentiation. The drugs Adalimumab and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and testes, and related phenotypes are craniofacial and hematopoietic system

MedlinePlus : 41 hidradenitis suppurativa (hs) is a chronic skin disease. it can occur in one or multiple areas of your body. hs usually develops in your armpits, groin, and anal area. it causes long-term skin inflammation and can be painful. symptoms include blackheads and red, tender bumps, called abscesses. the abscesses get bigger, break open, and leak pus tunnels that form under the skin between abscesses scarring no one knows what causes hs. it is more common in women, african americans, and people who have had acne. it usually starts after the teenage years. treatments include antibiotics, anti-inflammatory medicines, and sometimes surgery. losing weight or wearing looser clothing may help some patients avoid skin irritation.

Genetics Home Reference : 25 Hidradenitis suppurativa, also known as acne inversa, is a chronic skin disease characterized by recurrent boil-like lumps (nodules) under the skin. The nodules become inflamed and painful. They tend to break open (rupture), causing abscesses that drain fluid and pus. As the abscesses heal, they produce significant scarring of the skin.

Wikipedia : 72 Hidradenitis suppurativa (HS), also known as acne inversa, is a long term skin disease characterized by... more...

Related Diseases for Hidradenitis Suppurativa

Diseases related to Hidradenitis Suppurativa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
id Related Disease Score Top Affiliating Genes
1 neuropathy 29.4 KRT10 KRT14 TNF
2 pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 12.0
3 acne inversa, familial, 1 11.2
4 hidradenitis 11.2
5 perifolliculitis capitis abscedens et suffodiens, familial 11.1
6 acne inversa, familial, 3 11.1
7 acne inversa, familial, 2 11.1
8 acne 10.7
9 granuloma inguinale 10.6 NCSTN PSENEN
10 crohn's colitis 10.5 NOD2 TNF
11 neuromuscular disease 10.5 NOD2 TNF
12 amyotrophic lateral sclerosis type 10 10.5 NOD2 TNF
13 deafness, autosomal recessive 67 10.5 NOD2 TNF
14 oculo-cerebral dysplasia 10.5 IL17A NOD2
15 functional gastric disease 10.5 NOD2 TNF
16 squamous cell carcinoma 10.4
17 lung disease 10.4 IL17A TNF
18 primary systemic mycosis 10.4 IL17A TNF
19 yao syndrome 10.4 NOD2 TNF
20 crohn's disease 10.4
21 central nervous system leiomyosarcoma 10.4 IL17A TNF
22 lip cancer 10.4 NOD2 TNF
23 myopathy 10.4 NOD2 TNF
24 tricho onychic dysplasia 10.4 IL17A TNF
25 alkhurma hemorrhagic fever 10.4 IL17A TNF
26 benign dermal neurilemmoma 10.4 NCSTN PSEN1 PSENEN
27 tracheal stenosis 10.4 IL17A TNF
28 acute erythroid leukemia 10.4 NCSTN PSEN1 PSENEN
29 acute monoblastic leukemia 10.4 NOD2 TNF
30 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 10.4 IL17A TNF
31 cryptococcosis 10.3 IL17A TNF
32 keloids 10.3 IL17A TNF
33 pyoderma 10.3
34 pyoderma gangrenosum 10.3
35 membranoproliferative glomerulonephritis 10.3 NOD2 TNF
36 ostertagiasis 10.2 IL17A TNF
37 dowling-degos disease 10.2
38 psoriasis 10.2
39 arthritis 10.2
40 uremic neuropathy 10.2 IL17A KRT10
41 ptosis 10.2 KRT14 NCSTN PSENEN
42 pigmented basal cell carcinoma 10.2 KRT10 KRT14
43 c1 inhibitor deficiency 10.2 IL17A TNF
44 acantholytic acanthoma 10.2 KRT10 KRT14
45 spondyloarthropathy 10.2
46 penis squamous cell carcinoma 10.1 KRT10 KRT14
47 idiopathic neonatal atrial flutter 10.1 KRT10 KRT14
48 orbital osteomyelitis 10.1 IL17A TNF
49 epidermolysis bullosa simplex, koebner type 10.1 KRT10 KRT14
50 cellulitis 10.1

Graphical network of the top 20 diseases related to Hidradenitis Suppurativa:



Diseases related to Hidradenitis Suppurativa

Symptoms & Phenotypes for Hidradenitis Suppurativa

UMLS symptoms related to Hidradenitis Suppurativa:


exanthema, pruritus

MGI Mouse Phenotypes related to Hidradenitis Suppurativa:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.72 IL17A KRT14 NCSTN PSEN1 TNF
2 hematopoietic system MP:0005397 9.7 IL12RB1 IL17A KRT14 NCSTN NOD2 PSEN1
3 digestive/alimentary MP:0005381 9.65 IL17A KRT14 NOD2 PSEN1 TNF
4 immune system MP:0005387 9.5 IL12RB1 IL17A KRT14 NCSTN NOD2 PSEN1
5 mortality/aging MP:0010768 9.23 TNF DSG2 IL17A KRT14 NCSTN NOD2

Drugs & Therapeutics for Hidradenitis Suppurativa

Drugs for Hidradenitis Suppurativa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
2 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
3 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
4 Anesthetics Phase 4,Phase 1
5 Anti-Bacterial Agents Phase 3,Phase 2
6 Antibiotics, Antitubercular Phase 3
7
Etanercept Approved, Investigational Phase 2 185243-69-0
8
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
9
Ustekinumab Approved, Investigational Phase 2 815610-63-0
10
Infliximab Approved Phase 2 170277-31-3
11
Hydroxychloroquine Approved Phase 1, Phase 2 118-42-3 3652
12
Drospirenone Approved Phase 2 67392-87-4 68873
13
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
14
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
15 Immunosuppressive Agents Phase 2
16 Anti-Infective Agents Phase 2,Phase 1
17 Dermatologic Agents Phase 2
18 Hormone Antagonists Phase 2
19 Hormones Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
21 Analgesics Phase 2
22 Analgesics, Non-Narcotic Phase 2
23 Anti-Inflammatory Agents, Non-Steroidal Phase 2
24 Gastrointestinal Agents Phase 2
25 Peripheral Nervous System Agents Phase 2
26 Angiogenesis Inhibitors Phase 2
27 Angiogenesis Modulating Agents Phase 2
28 Antibodies Phase 2,Phase 1,Early Phase 1
29 Antibodies, Monoclonal Phase 2,Phase 1,Early Phase 1
30 Immunoglobulins Phase 2,Phase 1,Early Phase 1
31 Interleukin 1 Receptor Antagonist Protein Phase 2
32 Complement System Proteins Phase 2
33 Antimalarials Phase 1, Phase 2
34 Antiparasitic Agents Phase 1, Phase 2
35 Antiprotozoal Agents Phase 1, Phase 2
36 Contraceptive Agents Phase 2
37 Contraceptives, Oral Phase 2
38 diuretics Phase 2
39 Diuretics, Potassium Sparing Phase 2
40 Drospirenone and ethinyl estradiol combination Phase 2
41 Estradiol 17 beta-cypionate Phase 2
42 Estradiol 3-benzoate Phase 2
43 Estradiol valerate Phase 2 979-32-8
44 Estrogens Phase 2
45 Mineralocorticoid Receptor Antagonists Phase 2
46 Mineralocorticoids Phase 2
47 Natriuretic Agents Phase 2
48 Polyestradiol phosphate Phase 2
49
Phenol Approved, Experimental Phase 1 108-95-2 996
50 Pharmaceutical Solutions Phase 1

Interventional clinical trials:

(show top 50) (show all 54)

id Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Humira (Adalimumab) for Hidradenitis Suppurativa (HS) Peri-Surgically (SHARPS Study) Recruiting NCT02808975 Phase 4 Adalimumab;Placebo
2 Cost-effectiveness of Adalimumab and Surgery vs Adalimumab in HS Not yet recruiting NCT03221621 Phase 4 Adalimumab Injection
3 Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa Completed NCT01468207 Phase 3
4 Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa Completed NCT01468233 Phase 3
5 Open-label Study of the Safety and Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa Completed NCT01635764 Phase 3
6 Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa Recruiting NCT02805595 Phase 3 23.4% Hypertonic saline;Saline
7 Open-label Study of Adalimumab in Japanese Subjects With Hidradenitis Suppurativa Active, not recruiting NCT02904902 Phase 3 Adalimumab
8 To Determine the Efficacy of a Laser Device for the Treatment of Hidradenitis Suppurativa Terminated NCT00367328 Phase 3
9 To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa Completed NCT00827996 Phase 2 adalimumab
10 Etanercept in Hidradenitis Suppurativa Completed NCT00329823 Phase 2 Etanercept sc 50mg per week for 12 weeks
11 Single Center Study of Apremilast for the Treatment of Hidradenitis Suppurativa Completed NCT02695212 Phase 2 Apremilast
12 Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa Patients Completed NCT02421172 Phase 2
13 Anakinra as a Treatment for Hydradenitis Suppurativa Completed NCT01516749 Phase 2 anakinra
14 Anakinra in Hidradenitis Suppurativa Completed NCT01558375 Phase 2 Water for injection;Anakinra
15 A Proof of Concept Study to Evaluate the Effectiveness of Ustekinumab in Hidradenitis Suppurativa Completed NCT01704534 Phase 2 Ustekinumab
16 Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa Completed NCT03001622 Phase 2
17 Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa Completed NCT00918255 Phase 2 Placebo
18 MABp1 IN HIDRADENITIS SUPPURATIVA REFRACTORY TO ADALIMUMAB Completed NCT02643654 Phase 2 MABp1;Placebo
19 Study to Assess the Safety and Efficacy of Infliximab to Treat Hidradenitis Suppurtativa Completed NCT00795574 Phase 2 infliximab;Placebo Comparator
20 Etanercept for Treatment of Hidradenitis Completed NCT00107991 Phase 2 etanercept
21 A Study to Test the Efficacy, Safety and Pharmacokinetics of Bimekizumab in Subjects With Moderate to Severe Hidradenitis Suppurativa. Recruiting NCT03248531 Phase 2 Bimekizumab;Adalimumab
22 Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa Recruiting NCT03275870 Phase 1, Phase 2 Hydroxychloroquine
23 Short-term Safety, Efficacy and Mode of Action of Apremilast in Moderate Suppurative Hidradenitis Active, not recruiting NCT03049267 Phase 2 Apremilast;Placebo Oral Tablet
24 Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis Suppurativa Terminated NCT01838499 Phase 2
25 A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HS Terminated NCT00722800 Phase 2 drospirenone and ethinyl estradiol (YAZ);Placebo
26 Efficacy and Safety of Efalizumab in the Treatment of Moderate-Severe Hydradenitis Suppurativa Completed NCT00134134 Phase 1 efalizumab
27 Endoscopic Pilonidal Sinus Treatment With Additional Crystalized Phenol Completed NCT02277340 Phase 1
28 An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa. Unknown status NCT01818167 10% Benzoyl Peroxide Topical Body Wash;Provodine Topical Cream
29 Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical Deroofing Unknown status NCT02163746
30 Trial Comparing Efficacy of Treatments for Hidradenitis Suppurativa Unknown status NCT01063270 Clindamycin & Rifampin
31 Efficacy of Percutaneous Injection of Triamcinolone in the Treatment of Mammillary Fistula Unknown status NCT01315080
32 Study on the Effect of NdYag Laser for the Treatment of Hidradenitis Suppurativa Completed NCT00494351
33 Quality of Life After Wide Surgical Excision in Patients With Hidradenitis Suppurativa Completed NCT02593604
34 A Small Clinical Study: Photodynamic Therapy to Treat Hidradenitis Suppurativa Completed NCT00395187
35 Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients Completed NCT02833909
36 Treatment of Hidradenitis Suppurativa Using Etanercept Completed NCT00949546 etanercept
37 Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients - a Multi cOuNtry studY in Real Life Setting Recruiting NCT02786576
38 Post-Marketing Surveillance of Adalimumab in Korean Hidradenitis Suppurativa Subjects Recruiting NCT03001115
39 A National Registry For Patients With Hidradenitis Suppurativa Recruiting NCT03289585
40 A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa. Recruiting NCT02781818 Triamcinolone Acetonide 10mg/mL;Triamcinolone Acetonide 40mg/mL;Normal Saline
41 Low Dose Radiotherapy for Advanced Hidradenitis Suppurativa Recruiting NCT03040804
42 Microwave Ablation in Mild Axillary Hidradenitis Suppurativa Recruiting NCT03238469
43 Exploratory Trial Evaluating Cosentyx (Secukinumab) for Patients With Moderate-to-Severe Hidradenitis Suppurativa Recruiting NCT03099980 Early Phase 1
44 Pilot Study on Botulinum Toxin B as Treatment for Hidradenitis Suppurativa Recruiting NCT03103074 Botulinum B Toxin
45 Canadian Humira Post Marketing Observational Epidemiological Study : Assessing Humira Real-life Effectiveness and Impact on HS Burden of Illness Recruiting NCT02896920
46 Treatment of Hidradenitis Suppurativa With Eth 755nm Alexandrite Laser Recruiting NCT03054155
47 Impact of Hidradenitis Suppurativa on Quality of Life Functions Recruiting NCT03288337
48 The Ohio State University Dermatology Biorepository, Molecular Biology and Genetics of Hidradenitis Suppurativa Recruiting NCT03146676
49 Group Psychotherapy for Patients With Hidradenitis Suppurativa: Effects in Quality of Life Recruiting NCT02904408
50 Intense Pulsed Light Therapy for Hidrosadenitis Suppurativa Recruiting NCT03203122

Search NIH Clinical Center for Hidradenitis Suppurativa

Cochrane evidence based reviews: hidradenitis suppurativa

Genetic Tests for Hidradenitis Suppurativa

Anatomical Context for Hidradenitis Suppurativa

MalaCards organs/tissues related to Hidradenitis Suppurativa:

39
Skin, Breast, Testes, Neutrophil, Endothelial, Myeloid, Pituitary

Publications for Hidradenitis Suppurativa

Articles related to Hidradenitis Suppurativa:

(show top 50) (show all 654)
id Title Authors Year
1
Langerhans Cell Histiocytosis With Clinical and Histologic Features of Hidradenitis Suppurativa: Brief Report and Review. ( 28937439 )
2017
2
A phenotype combining hidradenitis suppurativa with Dowling-Degos disease caused by a founder mutation in PSENEN. ( 28922471 )
2017
3
Interferon-gamma (IFN-I^) is Elevated in Wound Exudate from Hidradenitis Suppurativa. ( 27819528 )
2017
4
Hidradenitis Suppurativa and Concomitant Down Syndrome: Literature Review of Other Associated Mucocutaneous Manifestations in Adults. ( 28859733 )
2017
5
Population Pharmacokinetics and Immunogenicity of Adalimumab in Adult Patients with Moderate-to-Severe Hidradenitis Suppurativa. ( 28066879 )
2017
6
Low Utilization of the Dermatology Ambulatory Encounter among Patients with Hidradenitis Suppurativa: A Population-Based Retrospective Cohort Analysis in the USA. ( 28954266 )
2017
7
Successful Treatment of Severe Recalcitrant Hidradenitis Suppurativa with the Interleukin-17A Antibody Secukinumab. ( 28902952 )
2017
8
Uncovering burden disparity: A comparative analysis of the impact of moderate-to-severe psoriasis and hidradenitis suppurativa. ( 28917381 )
2017
9
Remission of hidradenitis suppurativa after bariatric surgery. ( 28932789 )
2017
10
Polyclonal hyperglobulinemia and elevated acute phase reactants in hidradenitis suppurativa. ( 28886222 )
2017
11
Prevalence and risk of inflammatory bowel disease in patients with hidradenitis suppurativa. ( 28089682 )
2017
12
Low and high body mass index in Hidradenitis suppurativa patients - different subtypes? ( 28940801 )
2017
13
Response to: 'Autoinflammatory disease damage index (ADDI): a possible newborn also in hidradenitis suppurativa daily practice' by Damiani et al. ( 28043999 )
2017
14
Proceeding report of the Symposium on Hidradenitis Suppurativa Advances (SHSA). ( 28898476 )
2017
15
Body fat composition in hidradenitis suppurativa: a hospital-based cross-sectional study. ( 28084004 )
2017
16
Review of Current Immunologic Therapies for Hidradenitis Suppurativa. ( 28912816 )
2017
17
Weekly adalimumab significantly reduces the number of abscesses and inflammatory nodules in patients with moderate to severe hidradenitis suppurativa. ( 28053204 )
2017
18
Factors Contributing to Depression and Chronic Pain in Patients with Hidradenitis Suppurativa: Results from a Single-Center Retrospective Review. ( 28068657 )
2017
19
IBD LIVE Series-Case 8: Treatment Options for Refractory Esophageal Crohn's Disease and Hidradenitis Suppurativa. ( 28906288 )
2017
20
Mucinous adenocarcinoma in association with hidradenitis suppurativa. ( 28597923 )
2017
21
Disseminate recurrent folliculitis as the presenting picture of hidradenitis suppurativa. ( 28838562 )
2017
22
Hidradenitis suppurativa treated with tetracycline in combination with colchicine: a prospective series of 20 patients. ( 28054351 )
2017
23
SAPHO syndrome associated with hidradenitis suppurativa and pyoderma gangrenosum successfully treated with adalimumab and methotrexate: a case report and review of the literature. ( 28884797 )
2017
24
Optimal Hidradenitis Suppurativa topical Treatment and Wound Care Management: A revised algorithm. ( 28952407 )
2017
25
Ectopic hidradenitis suppurativa on the dorsal foot of a road maker. ( 28932787 )
2017
26
Hidradenitis Suppurativa is Associated with Myocardial Infarction, but Not Stroke or Peripheral Arterial Disease of Lower Extremities. ( 28914960 )
2017
27
Quality of Life Measurement in Acne. Position Paper of the European Academy of Dermatology and Venereology (EADV) Task Forces on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS). ( 28898474 )
2017
28
Increased Suicide Risk in Patients with Hidradenitis Suppurativa. ( 28942360 )
2017
29
Glucagon-like peptide-1 agonists for treatment of hidradenitis suppurativa. ( 28940285 )
2017
30
A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report. ( 28868004 )
2017
31
Quality of Life and Psychosocial Implications in Patients with Hidradenitis Suppurativa. ( 28052274 )
2017
32
Clinical experience of the use of adalimumab in the management of hidradenitis suppurativa. Comparison of response rates with Crohn disease. ( 28081769 )
2016
33
Epidemiological, clinical and therapeutic aspects in special situations: hidradenitis suppurativa in paediatric patients. ( 28081770 )
2016
34
Phenotypic Characterization of Patients with Hidradenitis Suppurativa. ( 27576734 )
2016
35
Hidradenitis suppurativa-acne inversa-like lesions complicating naevus comedonicus: second case supporting the mechanical stress as a triggering factor. ( 27176082 )
2016
36
Hidradenitis suppurativa is not associated with the metabolic syndrome based on body type: A cross-sectional study. ( 27608328 )
2016
37
Genetic analysis of NCSTN for potential association with hidradenitis suppurativa in familial and nonfamilial patients. ( 26879264 )
2016
38
Adalimumab: A Review in Hidradenitis Suppurativa. ( 27665300 )
2016
39
Epidemiology of hidradenitis suppurativa and inflammatory bowel disease: are these two disease associated? ( 28081771 )
2016
40
When inflammation shifts to malignancy: extensive squamous cell carcinoma in a female hidradenitis suppurativa/acne inversa patient. ( 28036145 )
2016
41
Ustekinumab, another biologic with potential to help patients with hidradenitis suppurativa? ( 27115586 )
2016
42
Intrinsic defect in keratinocyte function leads to inflammation in Hidradenitis suppurativa. ( 27206704 )
2016
43
Bilateral Pedicled Superficial Inferior Epigastric Artery Flap in the Treatment of Hidradenitis Suppurativa. ( 27622101 )
2016
44
Clinical features of hidradenitis suppurativa and Crohn disease: what do these two entities have in common? ( 28081766 )
2016
45
Management of hidradenitis suppurativa in pregnancy. ( 28040373 )
2016
46
Reply to Lipsker et al. and Revuz on Hidradenitis Suppurativa Terminology: The Imaging Point of View. ( 27576573 )
2016
47
The Hidradenitis suppurativa patient journey in Italy: current status, unmet needs and opportunities. ( 27136185 )
2016
48
Hidradenitis Suppurativa and the Association With Hematological Malignancies: A Review of 2 Cases. ( 27573126 )
2016
49
Evaluating the Use of Hematological Parameters in Staging Hidradenitis Suppurativa. ( 28054922 )
2016
50
Management of hidradenitis suppurativa. ( 27585997 )
2016

Variations for Hidradenitis Suppurativa

Expression for Hidradenitis Suppurativa

Search GEO for disease gene expression data for Hidradenitis Suppurativa.

Pathways for Hidradenitis Suppurativa

Pathways related to Hidradenitis Suppurativa according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 DSG2 KRT10 KRT14 NCSTN PSENEN TNF
2
Show member pathways
12.27 IL12RB1 IL17A NOD2 TNF
3 11.97 NCSTN PSEN1 PSENEN
4
Show member pathways
11.93 NCSTN PSEN1 PSENEN
5 11.82 NCSTN PSEN1 PSENEN
6
Show member pathways
11.66 IL12RB1 IL17A TNF
7 11.48 IL12RB1 IL17A TNF
8
Show member pathways
11.36 NCSTN PSEN1 PSENEN
9 11.2 NCSTN PSEN1 PSENEN
10 11.05 IL17A TNF
11 10.99 NCSTN PSEN1 PSENEN
12 10.87 NOD2 TNF
13 10.55 NCSTN PSEN1 PSENEN
14 10.03 NCSTN PSEN1 PSENEN
15 10.02 PSEN1 PSENEN

GO Terms for Hidradenitis Suppurativa

Cellular components related to Hidradenitis Suppurativa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.33 IL12RB1 IL17A TNF
2 cell surface GO:0009986 9.26 DSG2 NOD2 PSEN1 TNF
3 gamma-secretase complex GO:0070765 8.8 NCSTN PSEN1 PSENEN

Biological processes related to Hidradenitis Suppurativa according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.75 DSG2 KRT10 KRT14
2 positive regulation of apoptotic process GO:0043065 9.73 NCSTN PSEN1 PSENEN TNF
3 Notch signaling pathway GO:0007219 9.65 NCSTN PSEN1 PSENEN
4 cornification GO:0070268 9.63 DSG2 KRT10 KRT14
5 positive regulation of interferon-gamma production GO:0032729 9.58 IL12RB1 TNF
6 positive regulation of catalytic activity GO:0043085 9.58 NCSTN PSEN1 PSENEN
7 positive regulation of interleukin-8 production GO:0032757 9.57 NOD2 TNF
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.56 NOD2 TNF
9 positive regulation of osteoclast differentiation GO:0045672 9.55 IL17A TNF
10 membrane protein intracellular domain proteolysis GO:0031293 9.54 NCSTN PSENEN
11 protein processing GO:0016485 9.54 NCSTN PSEN1 PSENEN
12 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.52 IL17A NOD2
13 beta-amyloid metabolic process GO:0050435 9.51 NCSTN PSEN1
14 membrane protein ectodomain proteolysis GO:0006509 9.5 NCSTN PSEN1 PSENEN
15 epithelial cell proliferation GO:0050673 9.49 NCSTN PSEN1
16 Notch receptor processing GO:0007220 9.43 NCSTN PSEN1 PSENEN
17 amyloid precursor protein metabolic process GO:0042982 9.33 NCSTN PSEN1 PSENEN
18 amyloid precursor protein catabolic process GO:0042987 9.13 NCSTN PSEN1 PSENEN
19 beta-amyloid formation GO:0034205 8.8 NCSTN PSEN1 PSENEN

Sources for Hidradenitis Suppurativa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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