MCID: HDR002
MIFTS: 42

Hidradenitis Suppurativa malady

Genetic diseases, Rare diseases, Skin diseases categories

Summaries for Hidradenitis Suppurativa

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NIH Rare Diseases:41 Hidradenitis suppurativa (hs) is a chronic skin disease characterized by recurrent, painful, boil-like lumps (nodules) under the skin. hs affects the areas around skin folds (e.g., armpits, groin, and breasts) and where apocrine glands (a form of sweat gland) and hair follicles are found. it is not contagious, but it is recurrent. it typically manifests as a single boil-like, pus-filled abscess or hard sebaceous lumps (lumps composed of sebum, or oil, which is excreted by the sebacous glands associated with hair follicles) and may progress to painful, deep-seated, inflamed clusters of lesions with chronic seepage involving significant scarring. in most cases, the cause of hs is unknown. it is likely that it results from a combination of genetic and environmental factors. some cases of hs have been associated with specific genes, including ncstn, psen1, and psenen.  last updated: 3/6/2015

MalaCards based summary: Hidradenitis Suppurativa, also known as acne inversa, is related to keratosis and skin disease. An important gene associated with Hidradenitis Suppurativa is NCSTN (nicastrin), and among its related pathways are Notch signaling pathway and Development NOTCH1 mediated pathway for NF KB activity modulation. The compounds tazarotene and isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lymph node, and related mouse phenotype mortality/aging.

MedlinePlus:32 Hidradenitis suppurativa (hs) is a chronic skin disease. it can occur in one or multiple areas of your body. hs usually develops in your armpits, groin, and anal area. it causes long-term skin inflammation and can be painful. symptoms include blackheads and red, tender bumps, called abscesses. the abscesses get bigger, break open, and leak pus tunnels that form under the skin between abscesses scarring no one knows what causes hs. it is more common in women, african americans, and people who have had acne. it usually starts after the teenage years. treatments include antibiotics, anti-inflammatory medicines, and sometimes surgery. losing weight or wearing looser clothing may help some patients avoid skin irritation.

Genetics Home Reference:21 Hidradenitis suppurativa, also known as acne inversa, is a chronic skin disease characterized by recurrent boil-like lumps (nodules) under the skin. The nodules become inflamed and painful. They tend to break open (rupture), causing abscesses that drain fluid and pus. As the abscesses heal, they produce significant scarring of the skin.

Wikipedia:63 Hidradenitis suppurativa (HS) is a rare, chronic skin disease characterized by clusters of abscesses or... more...

Aliases & Classifications for Hidradenitis Suppurativa

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Hidradenitis Suppurativa, Aliases & Descriptions:

Name: Hidradenitis Suppurativa 9 41 21 11 32 60
Acne Inversa 41 21
Hidradenitides, Suppurative 21
Suppurative Hidradenitides 21
 
Hidradenitis, Suppurative 21
Suppurative Hidradenitis 21
Acne Inversa, Familial 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:2280
MeSH33 D017497
ICD1025 L73.2

Related Diseases for Hidradenitis Suppurativa

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Graphical network of the top 20 diseases related to Hidradenitis Suppurativa:



Diseases related to hidradenitis suppurativa

Symptoms for Hidradenitis Suppurativa

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Drugs & Therapeutics for Hidradenitis Suppurativa

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Drug clinical trials:

Search ClinicalTrials for Hidradenitis Suppurativa

Search NIH Clinical Center for Hidradenitis Suppurativa

Genetic Tests for Hidradenitis Suppurativa

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Anatomical Context for Hidradenitis Suppurativa

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MalaCards organs/tissues related to Hidradenitis Suppurativa:

31
Skin, Breast, Lymph node, Myeloid, Endothelial, Pituitary, Neutrophil

Animal Models for Hidradenitis Suppurativa or affiliated genes

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MGI Mouse Phenotypes related to Hidradenitis Suppurativa:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.7KRT1, KRT10, NCSTN, PSENEN, DSG2

Publications for Hidradenitis Suppurativa

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Articles related to Hidradenitis Suppurativa:

(show top 50)    (show all 531)
idTitleAuthorsYear
1
Hidradenitis Suppurativa: New Opportunities for an Orphan Skin Disease. (25796270)
2015
2
Hidradenitis Suppurativa: a pilot study to determine patients capability to self-assess their Hurley stage. (25354349)
2014
3
Association of Metabolic Syndrome and Hidradenitis Suppurativa. (25229996)
2014
4
Successful treatment of severe hidradenitis suppurativa with anakinra. (23966107)
2013
5
Phenotypic heterogeneity in hidradenitis suppurativa (acne inversa): classification is an essential step toward personalized therapy. (23673498)
2013
6
Hidradenitis suppurativa and multiple dermatofibromas in a patient with ulcerative colitis. (24330184)
2013
7
Absence of pathogenic I^-secretase mutations in a South Wales cohort of familial and sporadic hidradenitis suppurativa (acne inversa). (23013355)
2013
8
Treatment of moderate to severe hidradenitis suppurativa. (23817709)
2013
9
Islanded perforator flaps in the reconstruction of hidradenitis suppurativa defects. (23303517)
2013
10
Predicting response to anti-TNF-alpha treatment in Hidradenitis suppurativa. (23362964)
2013
11
Clinical practice. Hidradenitis suppurativa. (22236226)
2012
12
Interstitial keratitis secondary to severe hidradenitis suppurativa responding to adalimumab. (22146546)
2012
13
Alterations in leucocyte subsets and histomorphology in normal-appearing perilesional skin and early and chronic hidradenitis suppurativa lesions. (21929531)
2012
14
Radical surgical excision and use of lateral thoracic flap for intractable axillary hidradenitis suppurativa. (23233895)
2012
15
Bacteriology of hidradenitis suppurativa exacerbations and deep tissue cultures obtained during carbon dioxide laser treatment. (22098253)
2012
16
Surgical treatment of chronic hidradenitis suppurativa in the gluteal and perianal regions. (23373365)
2012
17
Extended latissimus dorsi rotational V-Y advancement flap for the reconstruction of axillary defects after excision of hidradenitis suppurativa. (22374031)
2012
18
The thoracodorsal artery perforator flap in the treatment of axillary hidradenitis suppurativa: effect on preservation of arm abduction. (21921770)
2011
19
The perils of a defective medical communication: fatal neglected squamous cell carcinoma arising in perineal hidradenitis suppurativa. (21897818)
2011
20
Management of regional hidradenitis suppurativa with vacuum-assisted closure and split thickness skin grafts. (21587057)
2011
21
Superior and inferior gluteal artery perforator flaps in reconstruction of gluteal and perianal/perineal hidradenitis suppurativa lesions. (21976179)
2011
22
Dermacase. Can you identify this condition? Hidradenitis suppurativa. (21918148)
2011
23
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. (20628295)
2010
24
Hyperbaric oxygen therapy for the management of postsurgical wounds in hidradenitis suppurativa. (21352679)
2010
25
Hidradenitis suppurativa (or Acne inversa) with autosomal dominant inheritance is not linked to chromosome 1p21.1-1q25.3 region. (20698881)
2010
26
Effective long-term control of refractory hidradenitis suppurativa with adalimumab after failure of conventional therapy. (21091684)
2010
27
Hidradenitis suppurativa. (20883920)
2010
28
Biologic drugs for the treatment of hidradenitis suppurativa: an evidence-based review. (20510761)
2010
29
Lymph nodes in hidradenitis suppurativa. (19365106)
2009
30
Etanercept for the treatment of hidradenitis suppurativa. (19197548)
2009
31
Hidradenitis suppurativa: importance of early treatment; efficient treatment with electrosurgery. (18093196)
2008
32
Quality of life impairment in hidradenitis suppurativa: a study of 61 cases. (17097366)
2007
33
Real-time compound imaging ultrasound of hidradenitis suppurativa. (17958586)
2007
34
A hidradenitis suppurativa related SAPHO case associated with features resembling spondylarthropathy and proteinuria. (16680392)
2007
35
The cutting edge. Severe hidradenitis suppurativa treated with adalimumab. (16982997)
2006
36
Surgical treatment of hidradenitis suppurativa: case series and review of the literature. (16984573)
2006
37
Clindamycin and rifampicin combination therapy for hidradenitis suppurativa. (16634904)
2006
38
Etanercept: effective in the management of hidradenitis suppurativa. (16536817)
2006
39
Treatment of long-standing extensive perianal hidradenitis suppurativa using double rotation plasty, V-Y plasty and free grafts. (12838364)
2004
40
Hidradenitis suppurativa. (12457209)
2003
41
Vulvar hidradenitis suppurativa. Immunohistochemical evaluation of apocrine and eccrine involvement. (12380447)
2002
42
Split-thickness skin grafts and negative-pressure dressings in the treatment of axillary hidradenitis suppurativa. (12479426)
2002
43
Hidradenitis suppurativa. (11193069)
2000
44
The natural history of hidradenitis suppurativa. (11305381)
2000
45
Cigarette smoking as a triggering factor of hidradenitis suppurativa. (10393449)
1999
46
Pyoderma gangrenosum associated with cystic acne and hidradenitis suppurativa controlled by adding minocycline and sulfasalazine to the treatment regimen. (8726710)
1996
47
Cyclosporin-responsive hidradenitis suppurativa. (7636825)
1995
48
Surgical management of severe mammary hidradenitis suppurativa. (3341719)
1988
49
Hidradenitis suppurativa of the anogenital region: response to isotretinoin. (3422131)
1988
50
Fox-Fordyce disease with hidradenitis suppurativa. (13563958)
1958

Variations for Hidradenitis Suppurativa

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Expression for genes affiliated with Hidradenitis Suppurativa

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Search GEO for disease gene expression data for Hidradenitis Suppurativa.

Pathways for genes affiliated with Hidradenitis Suppurativa

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Pathways related to Hidradenitis Suppurativa according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Delta-Notch Signaling Pathway36
Notch Signaling Pathway36
9.6NCSTN, PSENEN
2
Show member pathways
Development Notch Signaling Pathway58
Transcription Sin3 and NuRD in transcription regulation58
9.6NCSTN, PSENEN
3
Show member pathways
9.6NCSTN, PSENEN
4
Show member pathways
9.6NCSTN, PSENEN
5
Show member pathways
Alzheimers Disease36
9.6NCSTN, PSENEN
69.6NCSTN, PSENEN
79.6NCSTN, PSENEN
89.6PSENEN, NCSTN
9
Show member pathways
9.6PSENEN, NCSTN
10
Show member pathways
9.6NCSTN, PSENEN
11
Show member pathways
9.6NCSTN, PSENEN
129.6NCSTN, PSENEN
13
Show member pathways
Notch signaling pathway36
9.6NCSTN, PSENEN
149.6NCSTN, PSENEN
15
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.3DSC2, DSG2

Compounds for genes affiliated with Hidradenitis Suppurativa

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Sources:
43Novoseek, 12DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Hidradenitis Suppurativa according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1tazarotene43 1210.2KRT1, KRT10
2isotretinoin43 1210.2KRT1, KRT10
3isoleucine439.1KRT1, KRT10
4bromodeoxyuridine439.1KRT1, KRT10
5hematoxylin439.0KRT10, KRT1
6calcium43 49 24 1210.7KRT1, KRT10, DSG2, DSC2

GO Terms for genes affiliated with Hidradenitis Suppurativa

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Cellular components related to Hidradenitis Suppurativa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:00300579.2DSG2, DSC2
2keratin filamentGO:00450959.1KRT1, KRT10
3extracellular vesicular exosomeGO:00700627.6KRT1, KRT10, NCSTN, DSG2, DSC2
4plasma membraneGO:00058867.3DSC2, DSG2, PSENEN, NCSTN, KRT1

Biological processes related to Hidradenitis Suppurativa according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1amyloid precursor protein catabolic processGO:00429879.9NCSTN, PSENEN
2membrane protein intracellular domain proteolysisGO:00312939.8NCSTN, PSENEN
3membrane protein ectodomain proteolysisGO:00065099.8NCSTN, PSENEN
4Notch receptor processingGO:00072209.7PSENEN, NCSTN
5protein processingGO:00164859.7NCSTN, PSENEN
6positive regulation of catalytic activityGO:00430859.6NCSTN, PSENEN
7bundle of His cell to Purkinje myocyte communicationGO:00860699.6DSG2, DSC2
8ventricular cardiac muscle cell action potentialGO:00860059.5DSC2, DSG2
9apoptotic signaling pathwayGO:00971909.5PSENEN, NCSTN
10regulation of heart rate by cardiac conductionGO:00860919.5DSG2, DSC2
11homophilic cell adhesionGO:00071569.3DSG2, DSC2
12Notch signaling pathwayGO:00072199.3NCSTN, PSENEN

Products for genes affiliated with Hidradenitis Suppurativa

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  • Antibodies
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Sources for Hidradenitis Suppurativa

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet