MCID: HDR006
MIFTS: 42

Hidradenocarcinoma malady

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Hidradenocarcinoma

About this section

Aliases & Descriptions for Hidradenocarcinoma:

Name: Hidradenocarcinoma 47
Primary Mucoepidermoid Cutaneous Carcinoma 47
Malignant Nodular/clear Cell Hidradenoma 47
Malignant Clear Cell Acrospiroma 47
 
Clear Cell Eccrine Carcinoma 47
Sweat Gland Adenocarcinoma 67
Eccrine Ductal Carcinoma 67
Malignant Acrospiroma 47

Classifications:



Summaries for Hidradenocarcinoma

About this section
Wikipedia:70 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

MalaCards based summary: Hidradenocarcinoma, also known as primary mucoepidermoid cutaneous carcinoma, is related to vulvar clear cell hidradenocarcinoma and malignant acrospiroma. An important gene associated with Hidradenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways are TP53 network and Validated targets of C-MYC transcriptional repression. Affiliated tissues include skin, breast and lymph node, and related mouse phenotypes are craniofacial and no phenotypic analysis.

Related Diseases for Hidradenocarcinoma

About this section

Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 270)
idRelated DiseaseScoreTop Affiliating Genes
1vulvar clear cell hidradenocarcinoma11.9
2malignant acrospiroma10.8
3eccrine porocarcinoma10.8
4breast granular cell tumor10.8ERBB2, PIP
5cystinosis, nephropathic10.7ERBB2, TP53
6lysosomal storage disease10.7BCL2, CCND1
7skeletal tuberculosis10.7CCND1, ERBB2
8mushroom workers' lung10.7S100B, TP53
9eyelid disease10.7ERBB2, ESR1
10kidney pelvis sarcomatoid transitional cell carcinoma10.6EGFR, ERBB2
11intermediate cell type ciliary body melanoma10.6CCND1, S100B
12pregnancy adenoma10.6ERBB2, KRT5
13cervical serous adenocarcinoma10.6ERBB2, TP53
14urethra adenocarcinoma10.6NKX2-1, TP63
15adult teratoma10.6BCL2, NKX2-1, TP53
16external ear disease10.5NKX2-1, S100B, TP53
17extragonadal nonseminomatous germ cell tumor10.5ERBB2, ESR1
18breast papillary carcinoma10.5EGFR, ERBB2, S100B
19mixed cell type kidney wilms' tumor10.5PGR, TP53
20split hand split foot malformation autosomal recessive10.5MKI67, TP53
21stenosis of lacrimal sac10.4BCL2, CCND1, TP53
22hypotonia10.4S100B, VIM
23gastric cancer10.4BCL2, CCND1, TP53
24pituitary carcinoma10.4CDX2, ERBB2, TP53
25bladder verrucous squamous cell carcinoma10.4CCND1, KRT5, TP53
26mantle cell lymphoma10.4BCL2, EGFR, TP53
27ampulla of vater adenocarcinoma10.4EGFR, ERBB2, MUC2
28oligodendroglioma10.4CCND1, KRT5, TP53
29anaplastic oligoastrocytoma10.4S100B, VIM
30septicemic plague10.4ERBB2, ESR1, TP53
31breast adenocarcinoma10.4KRT7, PIP
32classic pulmonary blastoma10.4EGFR, NKX2-1, TP53
33gastric squamous cell carcinoma10.4EGFR, ERBB2, KRT5
34cribriform carcinoma10.4EGFR, NKX2-1, TP53
35oral pharyngeal disorders10.4ERBB2, MKI67, TP53
36exstrophy-epispadias complex10.4S100B, VIM
37signet ring basal cell carcinoma10.4KRT7, TP63
38absence of fingerprints congenital milia10.4S100B, VIM
39vulvar angiokeratoma10.4ESR1, PGR
40rectum adenoma10.4KRT7, PIP
41x-linked congenital generalized hypertrichosis10.4BCL2, MKI67, TP53
42central nervous system organ benign neoplasm10.4ESR1, PGR
43fallopian tube benign neoplasm10.4ESR1, PGR
44drug-induced hepatitis10.4BCL2, CCND1, TP53
45appendix leiomyoma10.4ESR1, PGR
46mixed cell adenoma10.4ESR1, PGR
47antidepressant or antipsychotic toxicity or dose selection10.4BCL2, MKI67, TP53
48advanced sleep phase syndrome10.4CDX2, MUC2, TP53
49extrahepatic bile duct adenocarcinoma10.4CDX2, MUC2, TP53
50urticaria10.4EGFR, ERBB2, TP53

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to hidradenocarcinoma

Symptoms for Hidradenocarcinoma

About this section

Drugs & Therapeutics for Hidradenocarcinoma

About this section

Drugs for Hidradenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
nivolumabapprovedPhase 2326946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
2ImmunoglobulinsPhase 26045
3Antibodies, MonoclonalPhase 23795
4AntibodiesPhase 26045

Interventional clinical trials:

idNameStatusNCT IDPhase
1Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin CancersNot yet recruitingNCT02978625Phase 2

Search NIH Clinical Center for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

About this section

Anatomical Context for Hidradenocarcinoma

About this section

MalaCards organs/tissues related to Hidradenocarcinoma:

35
Skin, Breast, Lymph node

Animal Models for Hidradenocarcinoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Hidradenocarcinoma:

40 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9BCL2, CCND1, EGFR, ERBB2, KRT5, TP53
2MP:00030128.6EGFR, ESR1, KRT5, NKX2-1, PGR, TP53
3MP:00053698.4BCL2, EGFR, ERBB2, ESR1, PGR, TP53
4MP:00053888.3BCL2, CCND1, EGFR, ERBB2, ESR1, NKX2-1
5MP:00053718.3CDX2, EGFR, ERBB2, ESR1, KRT5, PGR
6MP:00053808.2CDX2, EGFR, ERBB2, ESR1, PGR, TP53
7MP:00053908.1CCND1, CDX2, EGFR, ERBB2, ESR1, NKX2-1
8MP:00107717.9BCL2, CCND1, EGFR, ERBB2, ESR1, KRT5
9MP:00020067.6BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
10MP:00053787.5BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
11MP:00053867.3BCL2, CCND1, ERBB2, ESR1, KRT5, NKX2-1
12MP:00028737.3CCND1, CDX2, EGFR, ERBB2, ESR1, MKI67
13MP:00053797.0BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
14MP:00053896.8BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
15MP:00053876.7BCL2, CCND1, EGFR, ESR1, MUC2, MUC5AC
16MP:00107686.6BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
17MP:00053816.3BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
18MP:00053855.9BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
19MP:00053845.7BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
20MP:00053765.1BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1

Publications for Hidradenocarcinoma

About this section

Articles related to Hidradenocarcinoma:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Whole exome sequencing of a patient with metastatic hidradenocarcinoma and review of the literature. (25918615)
2015
2
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. (26288440)
2015
3
Hidradenocarcinoma of the finger: a rare tumor, mimicking a giant cell tumor of the tendon sheath. (26319286)
2015
4
Management of Metastatic Apocrine Hidradenocarcinoma with Chemotherapy and Radiation. (26500736)
2015
5
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. (25627632)
2015
6
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. (25815059)
2015
7
Case report: clear cell hidradenocarcinoma of the nail bed. (26416223)
2015
8
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. (24490986)
2014
9
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. (25513929)
2014
10
Hidradenocarcinoma of the chest. (25382529)
2014
11
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. (25006935)
2014
12
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. (22998159)
2013
13
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. (23466792)
2013
14
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. (23053773)
2013
15
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. (23489214)
2013
16
Hidradenocarcinoma of the Finger. (23486133)
2013
17
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. (22678002)
2012
18
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. (23271300)
2012
19
No sweat, a rare case of hidradenocarcinoma. (22369809)
2012
20
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. (21892057)
2011
21
Hidradenocarcinoma of the fingertip: a case report and literature review. (21489038)
2011
22
Radiotherapy on hidradenocarcinoma. (22540063)
2011
23
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. (21844475)
2011
24
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. (21044227)
2010
25
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. (19522717)
2010
26
Perianal nodular hidradenocarcinoma. Case report. (20478121)
2010
27
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. (20572504)
2010
28
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. (19215270)
2009
29
Metastatic hidradenocarcinoma: Surgery and chemotherapy. (22666726)
2009
30
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. (20740144)
2009
31
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. (19476529)
2009
32
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (20596988)
2009
33
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. (19384064)
2009
34
Clear cell hidradenocarcinoma developing in pacemaker pocket. (18950311)
2008
35
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. (17214855)
2007
36
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. (17103407)
2007
37
Metastatic hidradenocarcinoma: efficacy of capecitabine. (17043204)
2006
38
Hidradenocarcinoma: a histological and immunohistochemical study. (17083691)
2006
39
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. (15355375)
2004
40
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. (10955691)
2000
41
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
42
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. (8626149)
1996
43
Metastatic clear-cell hidradenocarcinoma of the vulva. (8428700)
1993
44
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. (2984259)
1985
45
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. (6328124)
1984
46
Clear cell hidradenocarcinoma. Report of an unusual case. (190056)
1976
47
Hidradenocarcinoma: report of a case. (4310623)
1969
48
Clear cell hidradenoma and hidradenocarcinoma. (14032110)
1963
49
A clear-cell hidradenocarcinoma with metastases. (13472651)
1957
50
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952

Variations for Hidradenocarcinoma

About this section

Expression for genes affiliated with Hidradenocarcinoma

About this section
Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for genes affiliated with Hidradenocarcinoma

About this section

Pathways related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8BCL2, TP53, TP63
29.8BCL2, CCND1, ERBB2
39.8BCL2, CCND1, TP53
49.7EGFR, ERBB2, TP53
59.5CCND1, EGFR, ESR1
6
Show member pathways
9.5CCND1, EGFR, ESR1
7
Show member pathways
9.5BCL2, EGFR, ERBB2, TP53
89.5EGFR, ERBB2, VIM
99.5BCL2, EGFR, TP53, TP63
10
Show member pathways
9.5BCL2, CCND1, ERBB2, ESR1
119.4CCND1, EGFR, ERBB2, TP53
12
Show member pathways
9.4CCND1, EGFR, ERBB2, TP53
13
Show member pathways
9.4CCND1, EGFR, ERBB2, TP53
14
Show member pathways
9.4CCND1, EGFR, ERBB2, TP53
15
Show member pathways
9.3CCND1, EGFR, ERBB2, ESR1
16
Show member pathways
9.2BCL2, CCND1, EGFR, ERBB2, TP53
17
Show member pathways
9.2BCL2, CCND1, EGFR, ERBB2, TP53
189.2BCL2, CCND1, EGFR, ERBB2, TP53
199.2CCND1, EGFR, TP53, VIM
209.1CCND1, EGFR, ERBB2, ESR1, TP53
219.1BCL2, CCND1, EGFR, ESR1, TP53
228.9BCL2, CCND1, EGFR, ERBB2, ESR1, TP53
238.9CCND1, MKI67, TP53, TP63, VIM
248.5BCL2, CCND1, EGFR, ERBB2, TP53, TP63

GO Terms for genes affiliated with Hidradenocarcinoma

About this section

Cellular components related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056345.6BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
2cytoplasmGO:00057375.6BCL2, CCND1, EGFR, ERBB2, ESR1, KRT5

Biological processes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.6TP53, TP63
2regulation of mitochondrial membrane permeabilityGO:004690210.6BCL2, TP53
3epithelial cell developmentGO:000206410.6ESR1, TP63
4response to UV-AGO:007014110.5CCND1, EGFR
5positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:190074010.4BCL2, TP53, TP63
6Leydig cell differentiationGO:003332710.4CCND1, NKX2-1
7response to X-rayGO:001016510.3CCND1, TP53, TP63
8mitotic G1 DNA damage checkpointGO:003157110.3CCND1, TP53, TP63
9cerebral cortex cell migrationGO:002179510.3EGFR, NKX2-1
10response to glucocorticoidGO:005138410.3BCL2, CCND1, S100B
11response to gamma radiationGO:001033210.3BCL2, TP53, TP63
12cell agingGO:000756910.2BCL2, TP53, TP63
13epidermis developmentGO:000854410.1EGFR, KRT5, TP63
14pattern specification processGO:000738910.1CDX2, NKX2-1, TP63
15positive regulation of epithelial cell proliferationGO:005067910.0EGFR, ERBB2, ESR1
16animal organ morphogenesisGO:00098879.9BCL2, CDX2, NKX2-1, TP63
17regulation of apoptotic processGO:00429819.8BCL2, ESR1, TP53, TP63
18positive regulation of cell growthGO:00303079.7BCL2, EGFR, ERBB2
19positive regulation of cell proliferationGO:00082849.0BCL2, CCND1, CDX2, EGFR, S100B
20positive regulation of gene expressionGO:00106288.8ERBB2, NKX2-1, PIP, TP53, VIM
21cell proliferationGO:00082838.7BCL2, EGFR, ERBB2, MKI67, S100B, TP53
22negative regulation of transcription from RNA polymerase II promoterGO:00001228.5CCND1, CDX2, ESR1, NKX2-1, TP53, TP63

Molecular functions related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase regulator activityGO:003023510.5EGFR, ESR1
2protein phosphatase bindingGO:001990310.0BCL2, EGFR, ERBB2, TP53
3double-stranded DNA bindingGO:00036909.8CDX2, EGFR, TP53, TP63
4glycoprotein bindingGO:00019489.6EGFR, PIP, VIM
5sequence-specific DNA bindingGO:00435659.5BCL2, CDX2, NKX2-1, TP53, TP63
6enzyme bindingGO:00198998.8CCND1, EGFR, ESR1, NKX2-1, PGR, TP53
7identical protein bindingGO:00428028.1BCL2, EGFR, ERBB2, ESR1, S100B, TP53
8protein bindingGO:00055153.9BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1

Sources for Hidradenocarcinoma

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet