MCID: HDR006
MIFTS: 42

Hidradenocarcinoma malady

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Hidradenocarcinoma

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Aliases & Descriptions for Hidradenocarcinoma:

Name: Hidradenocarcinoma 46
Primary Mucoepidermoid Cutaneous Carcinoma 46
Malignant Nodular/clear Cell Hidradenoma 46
Malignant Clear Cell Acrospiroma 46
 
Clear Cell Eccrine Carcinoma 46
Sweat Gland Adenocarcinoma 66
Eccrine Ductal Carcinoma 66
Malignant Acrospiroma 46

Classifications:



Summaries for Hidradenocarcinoma

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NIH Rare Diseases:46 Hidradenocarcinoma is a rare tumor caused by the abnormal growth of cells in a sweat gland.  it is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but can be been found on other parts of the body. this type of tumor most often develops in people between the ages of 30-60 years old, but has been found in children.  hidradenocarcinoma is usually painless and tends to grow slowly, but may spread into nearby tissues, especially lymph nodes, or to more distant parts of the body (metastasis). the cause of the tumor is unknown. diagnosis is usually made by careful examination and a series of special skin tests. the main treatment is surgical removal of the tumor often followed by radiation therapy and/or chemotherapy. long term outlook is best when the cancer is found early. last updated: 8/24/2016

MalaCards based summary: Hidradenocarcinoma, also known as primary mucoepidermoid cutaneous carcinoma, is related to vulvar clear cell hidradenocarcinoma and eyelid disease. An important gene associated with Hidradenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways are EGFR Signaling Pathway and Central carbon metabolism in cancer. Affiliated tissues include skin, lymph node and testes, and related mouse phenotypes are craniofacial and muscle.

Wikipedia:69 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Related Diseases for Hidradenocarcinoma

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Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 248)
idRelated DiseaseScoreTop Affiliating Genes
1vulvar clear cell hidradenocarcinoma12.0
2eyelid disease10.9ERBB2, ESR1
3gelatinous ascites10.9ERBB2, ESR1
4kidney pelvis sarcomatoid transitional cell carcinoma10.9EGFR, ERBB2
5pregnancy adenoma10.8ERBB2, KRT5
6cutaneous mucoepidermoid carcinoma10.8ERBB2, KRT5
7ossifying fibromyxoid tumor10.8EGFR, ERBB2
8breast granular cell tumor10.8ERBB2, PIP
9cystinosis, nephropathic10.8ERBB2, TP53
10signet ring basal cell carcinoma10.8KRT7, TP63
11her2-receptor negative breast cancer10.8EGFR, ERBB2
12trigeminal nerve disease10.8ERBB2, ESR1
13extragonadal nonseminomatous germ cell tumor10.8ERBB2, ESR1
14breast adenocarcinoma10.7KRT7, PIP
15cervical serous adenocarcinoma10.7ERBB2, TP53
16rectum adenoma10.7KRT7, PIP
17subareolar duct papillomatosis10.7KRT7, MUC5AC
18glottis verrucous carcinoma10.7EGFR, ERBB2, ESR1
19gastric squamous cell carcinoma10.7EGFR, ERBB2, KRT5
20skeletal tuberculosis10.7CCND1, ERBB2
21papillary thymic adenocarcinoma10.7ERBB2, ESR1, KRT5
22uterine disease10.7KRT7, MUC5AC
23anomalous left coronary artery from the pulmonary artery10.7EGFR, ERBB2, ESR1
24cholesteatoma of external ear10.7ERBB2, ESR1, TP53
25animal phobia10.7EGFR, ERBB2, TP53
26cryptosporidiosis10.7KRT5, TP53
27leiomyosarcoma10.7ERBB2, ESR1, TP53
28adenocarcinoma in situ10.7ERBB2, ESR1, PIP
29breast adenoma10.7ERBB2, ESR1, TP53
30bronchiolo-alveolar adenocarcinoma10.7ERBB2, KRT5, KRT7
31familial periodic paralysis10.6KRT5, KRT7
32anterior horn cell disease10.6KRT7, PIP
33bartholin's gland adenoid cystic carcinoma10.6EGFR, ESR1
34split hand split foot malformation autosomal recessive10.6MKI67, TP53
35epidermolytic acanthoma10.6KRT5, KRT7
36ovarian small cell carcinoma10.6EGFR, ERBB2, TP53
37mixed cerebral palsy10.6ERBB2, ESR1, TP53
38water-clear cell adenoma10.6KRT5, KRT7, TP63
39distal monosomy 9p10.6EGFR, ERBB2, TP53
40pineal region meningioma10.6ERBB2, ESR1, TP53
41cardiac diverticulum10.6KRT7, VIM
42childhood malignant schwannoma10.6MKI67, MUC5AC
43localized epiphyseal dysplasia10.6ESR1, TP53, TP63
44myoepithelial carcinoma10.6EGFR, KRT5, TP53
45pemphigus vulgaris, familial10.6ERBB2, KRT7, PIP
46heel spur10.6ERBB2, KRT7, PIP
47her2-receptor positive breast cancer10.6ERBB2, ESR1
48vulva squamous cell carcinoma10.6ERBB2, KRT7, PIP
49septicemic plague10.6ERBB2, ESR1, TP53
50thymus adenocarcinoma10.6ESR1, KRT7, PIP

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to hidradenocarcinoma

Symptoms for Hidradenocarcinoma

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Drugs & Therapeutics for Hidradenocarcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

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Anatomical Context for Hidradenocarcinoma

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MalaCards organs/tissues related to Hidradenocarcinoma:

34
Skin, Lymph node, Testes, Breast

Animal Models for Hidradenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Hidradenocarcinoma:

39 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.2BCL2, CCND1, EGFR, ERBB2, KRT5, TP53
2MP:00053699.0BCL2, EGFR, ERBB2, ESR1, TP53, TP63
3MP:00107718.5BCL2, CCND1, EGFR, ERBB2, ESR1, KRT5
4MP:00053918.3BCL2, CCND1, EGFR, MUC5AC, TP53, TP63
5MP:00053718.2CDX2, EGFR, ERBB2, ESR1, KRT5, TP53
6MP:00053888.2BCL2, CCND1, EGFR, ERBB2, ESR1, NKX2-1
7MP:00053908.0CCND1, CDX2, EGFR, ERBB2, ESR1, NKX2-1
8MP:00020067.6BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
9MP:00028737.5CCND1, CDX2, EGFR, ERBB2, ESR1, MKI67
10MP:00053867.5BCL2, CCND1, ERBB2, ESR1, KRT5, NKX2-1
11MP:00053877.2BCL2, CCND1, EGFR, ESR1, MUC2, MUC5AC
12MP:00053787.1BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
13MP:00107687.0BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
14MP:00053896.9BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
15MP:00053796.6BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
16MP:00053856.3BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
17MP:00053816.0BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
18MP:00053845.9BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
19MP:00053765.3BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1

Publications for Hidradenocarcinoma

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Articles related to Hidradenocarcinoma:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Whole exome sequencing of a patient with metastatic hidradenocarcinoma and review of the literature. (25918615)
2015
2
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. (26288440)
2015
3
Hidradenocarcinoma of the finger: a rare tumor, mimicking a giant cell tumor of the tendon sheath. (26319286)
2015
4
Management of Metastatic Apocrine Hidradenocarcinoma with Chemotherapy and Radiation. (26500736)
2015
5
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. (25627632)
2015
6
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. (25815059)
2015
7
Case report: clear cell hidradenocarcinoma of the nail bed. (26416223)
2015
8
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. (24490986)
2014
9
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. (25513929)
2014
10
Hidradenocarcinoma of the chest. (25382529)
2014
11
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. (25006935)
2014
12
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. (22998159)
2013
13
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. (23466792)
2013
14
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. (23053773)
2013
15
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. (23489214)
2013
16
Hidradenocarcinoma of the Finger. (23486133)
2013
17
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. (22678002)
2012
18
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. (23271300)
2012
19
No sweat, a rare case of hidradenocarcinoma. (22369809)
2012
20
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. (21892057)
2011
21
Hidradenocarcinoma of the fingertip: a case report and literature review. (21489038)
2011
22
Radiotherapy on hidradenocarcinoma. (22540063)
2011
23
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. (21844475)
2011
24
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. (21044227)
2010
25
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. (19522717)
2010
26
Perianal nodular hidradenocarcinoma. Case report. (20478121)
2010
27
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. (20572504)
2010
28
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. (19215270)
2009
29
Metastatic hidradenocarcinoma: Surgery and chemotherapy. (22666726)
2009
30
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. (20740144)
2009
31
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. (19476529)
2009
32
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (20596988)
2009
33
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. (19384064)
2009
34
Clear cell hidradenocarcinoma developing in pacemaker pocket. (18950311)
2008
35
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. (17214855)
2007
36
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. (17103407)
2007
37
Metastatic hidradenocarcinoma: efficacy of capecitabine. (17043204)
2006
38
Hidradenocarcinoma: a histological and immunohistochemical study. (17083691)
2006
39
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. (15355375)
2004
40
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. (10955691)
2000
41
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
42
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. (8626149)
1996
43
Metastatic clear-cell hidradenocarcinoma of the vulva. (8428700)
1993
44
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. (2984259)
1985
45
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. (6328124)
1984
46
Clear cell hidradenocarcinoma. Report of an unusual case. (190056)
1976
47
Hidradenocarcinoma: report of a case. (4310623)
1969
48
Clear cell hidradenoma and hidradenocarcinoma. (14032110)
1963
49
A clear-cell hidradenocarcinoma with metastases. (13472651)
1957
50
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952

Variations for Hidradenocarcinoma

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Cosmic variations for Hidradenocarcinoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM17483PTCH1skin,neck,carcinoma,NSc.1729-1G>Tp.?0
2COSM498HRASskin,neck,carcinoma,NSc.182A>Tp.Q61L0
3COSM14452PTCH1skin,neck,carcinoma,NSc.2321G>Ap.G774E0
4COSM516KRASskin,neck,carcinoma,NSc.34G>Tp.G12C0
5COSM29072PTCH1skin,neck,carcinoma,NSc.1067+1G>Ap.?0
6COSM29053PTCH1skin,neck,carcinoma,NSc.833G>Ap.W278*0
7COSM17468PTCH1skin,neck,carcinoma,NSc.584G>Tp.R195M0

Expression for genes affiliated with Hidradenocarcinoma

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Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for genes affiliated with Hidradenocarcinoma

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Pathways related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathwaysScoreTop Affiliating Genes
19.7EGFR, ERBB2, TP53
29.7EGFR, ERBB2, TP53
39.7BCL2, EGFR, ERBB2
49.7CCND1, EGFR, ESR1
5
Show member pathways
9.7CCND1, EGFR, ESR1
6
Show member pathways
9.7EGFR, ERBB2, VIM
79.7BCL2, TP53, TP63
89.6BCL2, CCND1, ERBB2
99.6BCL2, CCND1, TP53
10
Show member pathways
9.5CCND1, EGFR, ERBB2, ESR1
11
Show member pathways
9.4BCL2, EGFR, ERBB2, TP53
12
Show member pathways
9.4CCND1, EGFR, ERBB2, TP53
13
Show member pathways
9.4CCND1, EGFR, ERBB2, TP53
149.4CCND1, EGFR, ERBB2, TP53
15
Show member pathways
9.4CCND1, EGFR, ERBB2, TP53
16
Show member pathways
9.4BCL2, CCND1, ERBB2, ESR1
179.4BCL2, EGFR, TP53, TP63
18
Show member pathways
9.4BCL2, CCND1, ERBB2, TP53
199.3CCND1, EGFR, TP53, VIM
209.2CCND1, EGFR, ERBB2, ESR1, TP53
219.1BCL2, CCND1, EGFR, ERBB2, TP53
22
Show member pathways
9.1BCL2, CCND1, EGFR, ERBB2, TP53
23
Show member pathways
9.1BCL2, CCND1, EGFR, ERBB2, TP53
249.1BCL2, CCND1, EGFR, ESR1, TP53
259.0CCND1, MKI67, TP53, TP63, VIM
268.9BCL2, CCND1, EGFR, ERBB2, ESR1, TP53
278.5BCL2, CCND1, EGFR, ERBB2, TP53, TP63

GO Terms for genes affiliated with Hidradenocarcinoma

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Cellular components related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.9KRT5, KRT7, VIM
2cytoplasmGO:00057375.9BCL2, CCND1, EGFR, ERBB2, ESR1, KRT5
3nucleusGO:00056345.3BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1

Biological processes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.6TP53, TP63
2response to UV-AGO:007014110.5CCND1, EGFR
3regulation of mitochondrial membrane permeabilityGO:004690210.5BCL2, TP53
4epithelial cell developmentGO:000206410.5ESR1, TP63
5positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:190074010.3BCL2, TP53, TP63
6mitotic G1 DNA damage checkpointGO:003157110.3CCND1, TP53, TP63
7epidermis developmentGO:000854410.3EGFR, KRT5, TP63
8response to X-rayGO:001016510.2CCND1, TP53, TP63
9cerebral cortex cell migrationGO:002179510.2EGFR, NKX2-1
10response to gamma radiationGO:001033210.2BCL2, TP53, TP63
11Leydig cell differentiationGO:003332710.1CCND1, NKX2-1
12positive regulation of epithelial cell proliferationGO:005067910.1EGFR, ERBB2, ESR1
13response to glucocorticoidGO:005138410.0BCL2, CCND1, S100B
14cell agingGO:000756910.0BCL2, TP53, TP63
15regulation of apoptotic processGO:00429819.9BCL2, ESR1, TP53, TP63
16positive regulation of cell growthGO:00303079.8BCL2, EGFR, ERBB2
17pattern specification processGO:00073899.6CDX2, NKX2-1, TP63
18animal organ morphogenesisGO:00098879.4BCL2, CDX2, NKX2-1, TP63
19positive regulation of transcription, DNA-templatedGO:00458939.1CDX2, ESR1, NKX2-1, TP53, TP63
20cell proliferationGO:00082838.8BCL2, EGFR, ERBB2, MKI67, S100B, TP53
21positive regulation of cell proliferationGO:00082848.7BCL2, CCND1, CDX2, EGFR, S100B
22positive regulation of gene expressionGO:00106288.5ERBB2, NKX2-1, PIP, TP53, VIM
23negative regulation of transcription from RNA polymerase II promoterGO:00001228.1CCND1, CDX2, ESR1, NKX2-1, TP53, TP63

Molecular functions related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:000471610.8EGFR, ERBB2
2nitric-oxide synthase regulator activityGO:003023510.7EGFR, ESR1
3protein phosphatase bindingGO:00199039.9BCL2, EGFR, ERBB2, TP53
4double-stranded DNA bindingGO:00036909.7CDX2, EGFR, TP53, TP63
5glycoprotein bindingGO:00019489.5EGFR, PIP, VIM
6enzyme bindingGO:00198999.4CCND1, EGFR, ESR1, NKX2-1, TP53
7sequence-specific DNA bindingGO:00435658.7BCL2, CDX2, NKX2-1, TP53, TP63
8identical protein bindingGO:00428028.2BCL2, EGFR, ERBB2, ESR1, S100B, TP53
9protein bindingGO:00055153.8BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1

Sources for Hidradenocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet