MCID: HDR006
MIFTS: 50

Hidradenocarcinoma malady

Rare diseases, Endocrine diseases, Cancer diseases categories
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Summaries for Hidradenocarcinoma

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NIH Rare Diseases:42 Hidradenocarcinoma is a tumor caused by the abnormal growth of cells in a sweat gland.  it is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but it has also been found on other parts of the body.  this type of tumor typically develops in older individuals (after age 40).  each hidradenocarcinoma develops differently over time; some may stay the same size and others grow rapidly.  sometimes it may spread into nearby tissues, or to more distant parts of the body in a process called metastasis.  it is not known why some hidradenocarcinomas progress rapidly while others remain stable. last updated: 9/25/2013

MalaCards based summary: Hidradenocarcinoma, also known as clear cell eccrine carcinoma, is related to acrospiroma and nephrogenic adenoma. An important gene associated with Hidradenocarcinoma is KRT5 (keratin 5), and among its related pathways are Alzheimers Disease Pathway and Adherens junction. The compounds topotecan and afatinib have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lymph node, and related mouse phenotypes are craniofacial and no phenotypic analysis.

Wikipedia:65 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Aliases & Classifications for Hidradenocarcinoma

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Hidradenocarcinoma, Aliases & Descriptions:

Name: Hidradenocarcinoma 42
Clear Cell Eccrine Carcinoma 42 62
Malignant Acrospiroma 42 62
Primary Mucoepidermoid Cutaneous Carcinoma 42
 
Malignant Nodular/clear Cell Hidradenoma 42
Malignant Clear Cell Acrospiroma 42
Sweat Gland Adenocarcinoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Related Diseases for Hidradenocarcinoma

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Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1acrospiroma10.5
2nephrogenic adenoma10.5KRT7
3hidradenoma10.4
4giant cell glioblastoma10.3EGFR
5pseudomyxoma peritonei10.3KRT7, MUC5AC
6pancreatic ductal carcinoma10.3KRT7, MUC5AC
7breast fibroadenoma10.3ESR1
8meningioma10.3ESR1
9vulvar clear cell hidradenocarcinoma10.3
10cutaneous paget's disease10.3KRT7, ERBB2
11chordoma10.3KRT5, KRT7
12gallbladder cancer10.3MUC5AC, KRT7
13benign mesothelioma10.2KRT5, TP53
14thymus cancer10.2KRT7, TP63
15hypertrophic scars10.2TP63, KRT5
16actinic keratosis10.2TP63, TP53
17stomach cancer10.2ERBB2, TP53
18nodular hidradenoma10.2
19oxyphilic adenoma10.2KRT7, TP63
20skin benign neoplasm10.2TP63, KRT5
21biliary tract neoplasm10.2ERBB2, EGFR
22pleomorphic adenoma10.2ERBB2, TP63
23neuroendocrine carcinoma10.2TP63, KRT7
24sweat gland carcinoma10.2
25barrett's esophagus10.1MUC5AC, KRT7, TP53
26brain cancer10.1EGFR, TP53
27leiomyosarcoma10.1TP53, TP63
28male breast cancer10.1ESR1, ERBB2
29gastritis10.1MUC5AC, TP53
30malignant mesothelioma10.1KRT5, KRT7
31laryngeal benign neoplasm10.1EGFR, TP53
32cribriform carcinoma10.1ESR1, TP63
33bronchiolo-alveolar adenocarcinoma10.1KRT7, MUC5AC, EGFR
34abrikosov's tumor10.1ESR1, KRT7
35bladder carcinoma10.1ERBB2, TP53
36malignant mixed mullerian tumor10.1ERBB2, TP53, KRT7
37salivary gland adenoid cystic carcinoma10.1KRT7, TP63, ERBB2
38grade iii astrocytoma10.0EGFR, TP53
39papilloma10.0KRT5, TP53, TP63
40li-fraumeni syndrome10.0ESR1, ERBB2
41eccrine porocarcinoma10.0
42malignant acrospiroma10.0
43clear cell hidradenoma10.0
44pyogenic granuloma10.0
45pancreatic cancer10.0EGFR, MUC5AC, KRT7
46basal cell carcinoma10.0KRT7, TP53, TP63
47esophageal cancer10.0EGFR, TP53
48oral cancer10.0EGFR, TP53, KRT5
49squamous cell carcinoma of the head and neck10.0KRT5, EGFR, TP53
50kidney cancer10.0EGFR, KRT7, TP53

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to hidradenocarcinoma

Symptoms for Hidradenocarcinoma

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Drugs & Therapeutics for Hidradenocarcinoma

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Drug clinical trials:

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Genetic Tests for Hidradenocarcinoma

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Anatomical Context for Hidradenocarcinoma

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MalaCards organs/tissues related to Hidradenocarcinoma:

32
Skin, Breast, Lymph node

Animal Models for Hidradenocarcinoma or affiliated genes

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Publications for Hidradenocarcinoma

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Articles related to Hidradenocarcinoma:

(show all 43)
idTitleAuthorsYear
1
Hidradenocarcinoma of the chest. (25382529)
2014
2
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. (25006935)
2014
3
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. (24490986)
2014
4
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. (23489214)
2013
5
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. (22998159)
2013
6
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. (23466792)
2013
7
Hidradenocarcinoma of the Finger. (23486133)
2013
8
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. (23053773)
2013
9
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. (22678002)
2012
10
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. (23271300)
2012
11
No sweat, a rare case of hidradenocarcinoma. (22369809)
2012
12
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. (21892057)
2011
13
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. (21844475)
2011
14
Hidradenocarcinoma of the fingertip: a case report and literature review. (21489038)
2011
15
Radiotherapy on hidradenocarcinoma. (22540063)
2011
16
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. (21044227)
2010
17
Perianal nodular hidradenocarcinoma. Case report. (20478121)
2010
18
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. (20572504)
2010
19
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. (19522717)
2010
20
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. (19476529)
2009
21
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (20596988)
2009
22
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. (19384064)
2009
23
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. (19215270)
2009
24
Metastatic hidradenocarcinoma: Surgery and chemotherapy. (22666726)
2009
25
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. (20740144)
2009
26
Clear cell hidradenocarcinoma developing in pacemaker pocket. (18950311)
2008
27
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. (17214855)
2007
28
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. (17103407)
2007
29
Hidradenocarcinoma: a histological and immunohistochemical study. (17083691)
2006
30
Metastatic hidradenocarcinoma: efficacy of capecitabine. (17043204)
2006
31
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. (15355375)
2004
32
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. (10955691)
2000
33
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
34
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. (8626149)
1996
35
Metastatic clear-cell hidradenocarcinoma of the vulva. (8428700)
1993
36
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. (2984259)
1985
37
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. (6328124)
1984
38
Eccrine hidradenocarcinoma of the vulva with Paget's disease. Case report with a review of the literature. (6295435)
1983
39
Clear cell hidradenocarcinoma. Report of an unusual case. (190056)
1976
40
Hidradenocarcinoma: report of a case. (4310623)
1969
41
Clear cell hidradenoma and hidradenocarcinoma. (14032110)
1963
42
A clear-cell hidradenocarcinoma with metastases. (13472651)
1957
43
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952

Variations for Hidradenocarcinoma

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Expression for genes affiliated with Hidradenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Hidradenocarcinoma

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Pathways for genes affiliated with Hidradenocarcinoma

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Pathways related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6EGFR, ERBB2
29.6EGFR, ERBB2
3
Show member pathways
9.6ERBB2, EGFR
49.6ERBB2, EGFR
5
Show member pathways
9.6ERBB2, EGFR
69.6ERBB2, EGFR
79.6KRT5, KRT7
8
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.5EGFR, ESR1
99.5EGFR, ESR1
10
Show member pathways
9.4TP63, TP53
119.4EGFR, TP53
129.3ESR1, TP53
139.3ESR1, TP53
149.3TP53, ESR1
15
Show member pathways
9.1EGFR, ERBB2, ESR1
16
Show member pathways
9.1EGFR, ERBB2, ESR1
17
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.1EGFR, ERBB2, ESR1
18
Show member pathways
Signaling Pathways in Glioblastoma37
9.0EGFR, ERBB2, TP53
19
Show member pathways
9.0EGFR, ERBB2, TP53
209.0EGFR, ERBB2, TP53
219.0EGFR, ERBB2, TP53
22
Show member pathways
9.0EGFR, ERBB2, TP53
23
Show member pathways
9.0TP53, ERBB2, EGFR
249.0TP53, ERBB2, EGFR
25
Show member pathways
9.0TP53, ERBB2, EGFR
26
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.0TP53, ERBB2, EGFR
27
Show member pathways
Signal transduction PTEN pathway60
9.0TP53, ERBB2, EGFR
289.0EGFR, TP53, TP63
298.9EGFR, ESR1, TP53
308.6EGFR, ERBB2, TP53, TP63
318.5EGFR, ERBB2, ESR1, TP53
328.5TP53, ESR1, ERBB2, EGFR
33
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.5TP53, ESR1, ERBB2, EGFR
34
Show member pathways
8.5TP53, ESR1, ERBB2, EGFR
35
Show member pathways
8.5TP53, ESR1, ERBB2, EGFR

Compounds for genes affiliated with Hidradenocarcinoma

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Compounds related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1topotecan44 1111.4EGFR
2afatinib50 1110.9EGFR, ERBB2
3jnj 28871063 hydrochloride619.9ERBB2, EGFR
4alkylating agents509.9EGFR, ESR1
5ag 490619.9EGFR, ERBB2
6ag 1478 hydrochloride619.9ERBB2, EGFR
7iressa619.8ERBB2, EGFR
8pd158780449.8ERBB2, EGFR
9ag 1478449.8MUC5AC
10fadrozole449.6ERBB2, ESR1
11exemestane44 50 61 1112.5EGFR, ERBB2, ESR1
12anastrozole44 50 1111.5EGFR, ERBB2, ESR1
13everolimus44 50 1111.5EGFR, ERBB2, ESR1
14lapatinib44 50 1111.5ESR1, ERBB2, EGFR
15fulvestrant44 50 28 1112.5EGFR, ESR1, ERBB2
16letrozole44 50 61 1112.5EGFR, ESR1, ERBB2
17trastuzumab44 50 1111.4ERBB2, ESR1, EGFR
184-hydroxytamoxifen449.4ESR1, ERBB2, EGFR
19suberoylanilide hydroxamic acid449.4TP53, EGFR, ERBB2
20oxaliplatin44 50 1111.4ERBB2, TP53, EGFR
21radicicol44 61 1111.4ERBB2, ESR1, TP53
22flavopiridol44 1110.4ERBB2, TP53, EGFR
23n-(4-hydroxyphenyl)retinamide449.3ESR1, ERBB2, TP53
24bortezomib44 50 1111.3TP53, EGFR, ERBB2
25gefitinib44 50 1111.2ESR1, ERBB2, EGFR
26hematoxylin449.0TP63, MUC5AC, KRT7
27irinotecan44 50 1111.0EGFR, TP53, ERBB2
28progestin449.0EGFR, ERBB2, ESR1
29taxane448.9ESR1, ERBB2, EGFR, TP53
30geldanamycin44 50 61 1111.9TP53, ESR1, EGFR, ERBB2
31docetaxel44 50 61 1111.9TP53, ESR1, EGFR, ERBB2
32genistein44 28 61 2 24 1113.9ERBB2, KRT5, ESR1, EGFR
33tamoxifen44 50 28 1111.9ERBB2, ESR1, EGFR, TP53
34paclitaxel44 50 1110.8ESR1, EGFR, TP53, ERBB2
35ly294002448.8ESR1, TP53, EGFR, ERBB2
36carboplatin44 50 1110.7EGFR, ERBB2, TP53
37methotrexate50 44 1110.6KRT7, ERBB2, ESR1, MUC5AC
38n acetylcysteine448.6MUC5AC, ERBB2, EGFR, TP53
39arginine448.6TP63, TP53, ERBB2, KRT7, KRT5
40doxorubicin44 50 1110.5EGFR, ERBB2, TP63, ESR1, TP53
41cisplatin44 50 61 1111.5EGFR, ERBB2, ESR1, TP53, TP63
425fluorouracil448.1TP53, ESR1, MUC5AC, ERBB2, EGFR
43vegf448.0TP63, TP53, ESR1, ERBB2, KRT7, EGFR
44tyrosine447.9MUC5AC, ERBB2, EGFR, KRT5, KRT7, TP63
45retinoid447.6KRT5, MUC5AC, ESR1, EGFR, KRT7, TP53
46testosterone44 61 24 1110.5TP63, ESR1, MUC5AC, ERBB2, KRT7, KRT5
47retinoic acid44 248.2ESR1, MUC5AC, TP63, KRT7, EGFR, TP53
48paraffin446.9EGFR, TP63, TP53, ESR1, MUC5AC, ERBB2
49progesterone44 28 61 24 1110.9ESR1, TP53, TP63, EGFR, ERBB2, KRT7
50estrogen446.8TP63, TP53, ESR1, MUC5AC, EGFR, KRT5

GO Terms for genes affiliated with Hidradenocarcinoma

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Cellular components related to Hidradenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.4TP53, TP63
2cytoplasmGO:0057377.4EGFR, KRT5, KRT7, ERBB2, TP53, TP63

Biological processes related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell developmentGO:0020649.9ESR1, TP63
2cellular response to estradiol stimulusGO:0713929.8EGFR, ESR1
3mitotic G1 DNA damage checkpointGO:0315719.8TP53, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.8TP63, TP53
5positive regulation of nitric oxide biosynthetic processGO:0454299.7ESR1, EGFR
6response to X-rayGO:0101659.7TP53, TP63
7cell agingGO:0075699.7TP63, TP53
8positive regulation of MAP kinase activityGO:0434069.7ERBB2, EGFR
9response to gamma radiationGO:0103329.7TP53, TP63
10intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.7TP63, TP53
11cellular response to UVGO:0346449.6TP53, TP63
12neuron apoptotic processGO:0514029.6TP53, TP63
13positive regulation of fibroblast proliferationGO:0481469.6EGFR, ESR1
14positive regulation of epithelial cell proliferationGO:0506799.5EGFR, ERBB2
15cellular response to drugGO:0356909.4EGFR, TP53
16chromatin remodelingGO:0063389.2TP63, ESR1
17cell proliferationGO:0082839.2TP53, ERBB2, EGFR
18negative regulation of apoptotic processGO:0430669.0EGFR, TP53, TP63
19positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TP63, TP53, ESR1, EGFR

Molecular functions related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.9ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:0047169.8ERBB2, EGFR
3transmembrane receptor protein tyrosine kinase activityGO:0047149.7ERBB2, EGFR
4nitric-oxide synthase regulator activityGO:0302359.7ESR1, EGFR
5damaged DNA bindingGO:0036849.4TP53, TP63
6RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0010779.4TP63, TP53
7protein phosphatase bindingGO:0199039.3EGFR, ERBB2, TP53
8p53 bindingGO:0020399.1TP63, TP53
9enzyme bindingGO:0198999.0ESR1, TP53, EGFR
10protein heterodimerization activityGO:0469828.9EGFR, ERBB2, TP53
11chromatin bindingGO:0036828.7EGFR, ESR1, TP53, TP63
12identical protein bindingGO:0428028.4ESR1, TP53, TP63, EGFR, ERBB2
13protein bindingGO:0055157.4TP63, TP53, ESR1, KRT7, ERBB2, EGFR

Products for genes affiliated with Hidradenocarcinoma

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Sources for Hidradenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet