MCID: HDR006
MIFTS: 42

Hidradenocarcinoma malady

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Hidradenocarcinoma

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Aliases & Descriptions for Hidradenocarcinoma:

Name: Hidradenocarcinoma 45
Primary Mucoepidermoid Cutaneous Carcinoma 45
Malignant Nodular/clear Cell Hidradenoma 45
Malignant Clear Cell Acrospiroma 45
 
Clear Cell Eccrine Carcinoma 45
Sweat Gland Adenocarcinoma 65
Eccrine Ductal Carcinoma 65
Malignant Acrospiroma 45

Classifications:



External Ids:

UMLS65 C0334344

Summaries for Hidradenocarcinoma

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NIH Rare Diseases:45 Hidradenocarcinoma is a tumor caused by the abnormal growth of cells in a sweat gland.  it is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but it has also been found on other parts of the body.  this type of tumor typically develops in older individuals (after age 40).  each hidradenocarcinoma develops differently over time; some may stay the same size and others grow rapidly.  sometimes it may spread into nearby tissues, or to more distant parts of the body in a process called metastasis.  it is not known why some hidradenocarcinomas progress rapidly while others remain stable. last updated: 9/25/2013

MalaCards based summary: Hidradenocarcinoma, also known as primary mucoepidermoid cutaneous carcinoma, is related to vulvar clear cell hidradenocarcinoma and flat ductal epithelial atypia. An important gene associated with Hidradenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways are a6b1 and a6b4 Integrin signaling and Gastric cancer network 2. Affiliated tissues include breast, prostate and skin, and related mouse phenotypes are embryo and tumorigenesis.

Wikipedia:68 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Related Diseases for Hidradenocarcinoma

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Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1vulvar clear cell hidradenocarcinoma33.7KRT5, TP53
2flat ductal epithelial atypia10.7EGFR, ERBB2
3adenofibroma10.7EGFR, ERBB2
4her2-receptor positive breast cancer10.7EGFR, ERBB2
5eccrine papillary adenocarcinoma10.6EGFR, ERBB2
6protein-deficiency anemia10.6EGFR, ERBB2
7breast ductal adenoma10.6ERBB2, KRT5
8bile duct mucoepidermoid carcinoma10.6ERBB2, KRT5
9toxic encephalopathy10.6EGFR, ERBB2
10mixed eosinophil-basophil adenoma10.6EGFR, KRT5
11congenital disorder of glycosylation, type if10.6ERBB2, TP53
12pancreatic serous cystadenocarcinoma10.6ERBB2, TP53
13lymphatic system disease10.6EGFR, TP53
14hypogonadotropic hypogonadism-frontoparietal alopecia syndrome10.6EGFR, TP53
15ovarian mesodermal adenosarcoma10.6ERBB2, TP53
16thymus adenocarcinoma10.5ERBB2, KRT5
17microglandular adenosis10.5ERBB2, TP53
18renal artery obstruction10.5ERBB2, TP53
19cavernous hemangioma10.5EGFR, ERBB2
20endometrial mucinous adenocarcinoma10.5ERBB2, TP53
21signet ring basal cell carcinoma10.5KRT5, TP53
22nasal cavity adenocarcinoma10.5EGFR, ERBB2
23brain stem cancer10.5EGFR, TP53
24embryoma10.5EGFR, TP53
25basophilic carcinoma10.5ERBB2, TP53
26histoplasmosis10.5KRT5, TP53
27external ear squamous cell carcinoma10.5KRT5, TP53
28ampullary signet ring cell adenocarcinoma10.5EGFR, ERBB2
29comedo carcinoma10.5EGFR, TP53
30cystadenoma10.5KRT5, TP53
31epidermal nevus vitamin d resistant rickets10.5EGFR, ERBB2
32lip cancer10.5EGFR, TP53
33multiple skull base meningioma10.5EGFR, TP53
34pleomorphic carcinoma10.5KRT5, TP53
35soft tissue sarcoma childhood10.5EGFR, TP53
36sclerosing hemangioma10.5EGFR, ERBB2
37dermato-cardio-skeletal syndrome, borrone type10.5KRT5, TP53
38vulvar benign neoplasm10.5EGFR, TP53
39aortic aneurysm10.5KRT5, TP53
40bacterial exanthem10.4EGFR, ERBB2
41adult central nervous system mixed germ cell tumor10.4ERBB2, TP53
42pituitary gland disease10.4ERBB2, ESR1
43glaucoma iridogoniodysgenesia10.4ERBB2, ESR1
44substance abuse10.4ERBB2, TP53
45sebaceous adenocarcinoma10.4KRT5, TP63
46cribriform carcinoma10.4ERBB2, ESR1
47dental pulp calcification10.4ERBB2, ESR1
48fallopian tube leiomyosarcoma10.4ERBB2, TP53
49pancytopenia10.4EGFR, TP53
50apocrine adenosis of breast10.4ERBB2, ESR1

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to hidradenocarcinoma

Symptoms for Hidradenocarcinoma

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Drugs & Therapeutics for Hidradenocarcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

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Anatomical Context for Hidradenocarcinoma

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MalaCards organs/tissues related to Hidradenocarcinoma:

33
Breast, Prostate, Skin, Thyroid, Thymus, Ovary, Salivary gland

Animal Models for Hidradenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Hidradenocarcinoma:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5EGFR, ERBB2, ESR1, TP53, TP63
2MP:00020068.5EGFR, ERBB2, ESR1, TP53, TP63
3MP:00053888.4EGFR, ERBB2, ESR1, TP53, TP63
4MP:00053828.4EGFR, ERBB2, KRT5, TP53, TP63
5MP:00030128.3EGFR, ESR1, KRT5, TP53, TP63
6MP:00107718.0EGFR, ERBB2, ESR1, KRT5, TP53, TP63
7MP:00053718.0EGFR, ERBB2, ESR1, KRT5, TP53, TP63
8MP:00053697.9EGFR, ERBB2, ESR1, TP53, TP63
9MP:00053677.7EGFR, ESR1, KRT7, TP53, TP63
10MP:00053817.3EGFR, ERBB2, ESR1, KRT5, MUC5AC, TP53
11MP:00053766.7EGFR, ERBB2, ESR1, KRT7, MUC5AC, TP53

Publications for Hidradenocarcinoma

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Articles related to Hidradenocarcinoma:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis. (26876052)
2016
2
Management of Metastatic Apocrine Hidradenocarcinoma with Chemotherapy and Radiation. (26500736)
2015
3
Whole exome sequencing of a patient with metastatic hidradenocarcinoma and review of the literature. (25918615)
2015
4
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. (26288440)
2015
5
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. (25627632)
2015
6
Hidradenocarcinoma of the finger: a rare tumor, mimicking a giant cell tumor of the tendon sheath. (26319286)
2015
7
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. (25815059)
2015
8
Case report: clear cell hidradenocarcinoma of the nail bed. (26416223)
2015
9
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. (25513929)
2014
10
Hidradenocarcinoma of the chest. (25382529)
2014
11
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. (25006935)
2014
12
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. (24490986)
2014
13
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. (23489214)
2013
14
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. (22998159)
2013
15
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. (23466792)
2013
16
Hidradenocarcinoma of the Finger. (23486133)
2013
17
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. (23053773)
2013
18
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. (22678002)
2012
19
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. (23271300)
2012
20
No sweat, a rare case of hidradenocarcinoma. (22369809)
2012
21
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. (21892057)
2011
22
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. (21844475)
2011
23
Hidradenocarcinoma of the fingertip: a case report and literature review. (21489038)
2011
24
Radiotherapy on hidradenocarcinoma. (22540063)
2011
25
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. (21044227)
2010
26
Perianal nodular hidradenocarcinoma. Case report. (20478121)
2010
27
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. (20572504)
2010
28
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. (19522717)
2010
29
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. (19476529)
2009
30
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (20596988)
2009
31
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. (19384064)
2009
32
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. (19215270)
2009
33
Metastatic hidradenocarcinoma: Surgery and chemotherapy. (22666726)
2009
34
Clear cell hidradenocarcinoma developing in pacemaker pocket. (18950311)
2008
35
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. (17214855)
2007
36
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. (17103407)
2007
37
Hidradenocarcinoma: a histological and immunohistochemical study. (17083691)
2006
38
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. (15355375)
2004
39
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. (10955691)
2000
40
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
41
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. (8626149)
1996
42
Metastatic clear-cell hidradenocarcinoma of the vulva. (8428700)
1993
43
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. (2984259)
1985
44
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. (6328124)
1984
45
Eccrine hidradenocarcinoma of the vulva with Paget's disease. Case report with a review of the literature. (6295435)
1983
46
Clear cell hidradenocarcinoma. Report of an unusual case. (190056)
1976
47
Hidradenocarcinoma: report of a case. (4310623)
1969
48
Clear cell hidradenoma and hidradenocarcinoma. (14032110)
1963
49
A clear-cell hidradenocarcinoma with metastases. (13472651)
1957
50
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952

Variations for Hidradenocarcinoma

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Cosmic variations for Hidradenocarcinoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1COSM498HRASskin,neck,carcinoma,NS6
2COSM516KRASskin,neck,carcinoma,NS6
3COSM14452PTCH1skin,neck,carcinoma,NS6
4COSM17468PTCH1skin,neck,carcinoma,NS6
5COSM17483PTCH1skin,neck,carcinoma,NS6
6COSM29053PTCH1skin,neck,carcinoma,NS6
7COSM29072PTCH1skin,neck,carcinoma,NS6

Expression for genes affiliated with Hidradenocarcinoma

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Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for genes affiliated with Hidradenocarcinoma

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Pathways related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathwaysScoreTop Affiliating Genes
19.8EGFR, ERBB2
29.6EGFR, TP53
3
Show member pathways
9.5TP53, TP63
49.4ESR1, TP53
59.4ESR1, TP53
6
Show member pathways
9.3EGFR, ERBB2, TP53
7
Show member pathways
9.3EGFR, ERBB2, TP53
8
Show member pathways
9.3EGFR, ERBB2, TP53
99.3EGFR, ERBB2, TP53
10
Show member pathways
9.3EGFR, ERBB2, TP53
119.3EGFR, ERBB2, TP53
129.3EGFR, ERBB2, TP53
13
Show member pathways
9.3EGFR, ERBB2, TP53
14
Show member pathways
9.3EGFR, ERBB2, TP53
15
Show member pathways
9.1EGFR, ERBB2, ESR1
169.1EGFR, TP53, TP63
179.0EGFR, ESR1, TP53
188.8EGFR, ERBB2, TP53, TP63
198.7EGFR, ERBB2, ESR1, TP53
208.7EGFR, ERBB2, ESR1, TP53

GO Terms for genes affiliated with Hidradenocarcinoma

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Cellular components related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.2KRT5, KRT7

Biological processes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1ERBB2 signaling pathwayGO:003812810.2EGFR, ERBB2
2hair follicle developmentGO:000194210.1EGFR, TP63
3regulation of neuron apoptotic processGO:00435239.9ESR1, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.8TP53, TP63
5cell agingGO:00075699.8TP53, TP63
6intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.7TP53, TP63
7epithelial cell developmentGO:00020649.6ESR1, TP63
8gene expressionGO:00104678.8ESR1, TP53, TP63
9positive regulation of transcription from RNA polymerase II promoterGO:00459448.5EGFR, ESR1, TP53, TP63

Molecular functions related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:000471610.0EGFR, ERBB2
2ubiquitin protein ligase bindingGO:00316259.6EGFR, TP53

Sources for Hidradenocarcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet