MCID: HDR006
MIFTS: 49

Hidradenocarcinoma malady

Rare diseases, Endocrine diseases, Cancer diseases categories

Summaries for Hidradenocarcinoma

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NIH Rare Diseases:42 Hidradenocarcinoma is a tumor caused by the abnormal growth of cells in a sweat gland.  it is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but it has also been found on other parts of the body.  this type of tumor typically develops in older individuals (after age 40).  each hidradenocarcinoma develops differently over time; some may stay the same size and others grow rapidly.  sometimes it may spread into nearby tissues, or to more distant parts of the body in a process called metastasis.  it is not known why some hidradenocarcinomas progress rapidly while others remain stable. last updated: 9/25/2013

MalaCards based summary: Hidradenocarcinoma, also known as clear cell eccrine carcinoma, is related to acrospiroma and nephrogenic adenoma. An important gene associated with Hidradenocarcinoma is KRT5 (keratin 5), and among its related pathways are Alzheimers Disease Pathway and Adherens junction. The compounds topotecan and ag 490 have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lymph node, and related mouse phenotypes are craniofacial and no phenotypic analysis.

Wikipedia:64 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Aliases & Classifications for Hidradenocarcinoma

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Hidradenocarcinoma, Aliases & Descriptions:

Name: Hidradenocarcinoma 42
Clear Cell Eccrine Carcinoma 42 61
Malignant Acrospiroma 42 61
Primary Mucoepidermoid Cutaneous Carcinoma 42
 
Malignant Nodular/clear Cell Hidradenoma 42
Malignant Clear Cell Acrospiroma 42
Sweat Gland Adenocarcinoma 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Related Diseases for Hidradenocarcinoma

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Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1acrospiroma10.5
2nephrogenic adenoma10.5KRT7
3hidradenoma10.4
4giant cell glioblastoma10.3EGFR
5pseudomyxoma peritonei10.3KRT7, MUC5AC
6pancreatic ductal carcinoma10.3MUC5AC, KRT7
7breast fibroadenoma10.3ESR1
8meningioma10.3ESR1
9vulvar clear cell hidradenocarcinoma10.3
10cutaneous paget's disease10.3ERBB2, KRT7
11chordoma10.3KRT5, KRT7
12gallbladder cancer10.3KRT7, MUC5AC
13benign mesothelioma10.2KRT5, TP53
14thymus cancer10.2TP63, KRT7
15hypertrophic scars10.2TP63, KRT5
16stomach cancer10.2TP53, ERBB2
17actinic keratosis10.2TP63, TP53
18nodular hidradenoma10.2
19skin benign neoplasm10.2KRT5, TP63
20neuroendocrine carcinoma10.2TP63, KRT7
21biliary tract neoplasm10.2EGFR, ERBB2
22pleomorphic adenoma10.2ERBB2, TP63
23oxyphilic adenoma10.2TP63, KRT7
24sweat gland carcinoma10.2
25barrett's esophagus10.1TP53, MUC5AC, KRT7
26brain cancer10.1EGFR, TP53
27leiomyosarcoma10.1TP63, TP53
28gastritis10.1MUC5AC, TP53
29male breast cancer10.1ESR1, ERBB2
30laryngeal benign neoplasm10.1TP53, EGFR
31malignant mesothelioma10.1KRT5, KRT7
32cribriform carcinoma10.1TP63, ESR1
33bronchiolo-alveolar adenocarcinoma10.1MUC5AC, KRT7, EGFR
34abrikosov's tumor10.1KRT7, ESR1
35bladder carcinoma10.1ERBB2, TP53
36malignant mixed mullerian tumor10.1TP53, ERBB2, KRT7
37salivary gland adenoid cystic carcinoma10.1TP63, ERBB2, KRT7
38li-fraumeni syndrome10.0ERBB2, ESR1
39grade iii astrocytoma10.0EGFR, TP53
40papilloma10.0KRT5, TP53, TP63
41eccrine porocarcinoma10.0
42malignant acrospiroma10.0
43clear cell hidradenoma10.0
44pyogenic granuloma10.0
45pancreatic cancer10.0EGFR, KRT7, MUC5AC
46basal cell carcinoma10.0KRT7, TP53, TP63
47esophageal cancer10.0TP53, EGFR
48oral cancer10.0TP53, KRT5, EGFR
49squamous cell carcinoma of the head and neck10.0EGFR, KRT5, TP53
50kidney cancer10.0TP53, KRT7, EGFR

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to hidradenocarcinoma

Symptoms for Hidradenocarcinoma

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Drugs & Therapeutics for Hidradenocarcinoma

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Drug clinical trials:

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Genetic Tests for Hidradenocarcinoma

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Anatomical Context for Hidradenocarcinoma

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MalaCards organs/tissues related to Hidradenocarcinoma:

32
Skin, Breast, Lymph node

Animal Models for Hidradenocarcinoma or affiliated genes

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Publications for Hidradenocarcinoma

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Articles related to Hidradenocarcinoma:

(show all 43)
idTitleAuthorsYear
1
Hidradenocarcinoma of the chest. (25382529)
2014
2
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. (25006935)
2014
3
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. (24490986)
2014
4
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. (23489214)
2013
5
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. (22998159)
2013
6
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. (23466792)
2013
7
Hidradenocarcinoma of the Finger. (23486133)
2013
8
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. (23053773)
2013
9
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. (22678002)
2012
10
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. (23271300)
2012
11
No sweat, a rare case of hidradenocarcinoma. (22369809)
2012
12
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. (21892057)
2011
13
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. (21844475)
2011
14
Hidradenocarcinoma of the fingertip: a case report and literature review. (21489038)
2011
15
Radiotherapy on hidradenocarcinoma. (22540063)
2011
16
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. (21044227)
2010
17
Perianal nodular hidradenocarcinoma. Case report. (20478121)
2010
18
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. (20572504)
2010
19
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. (19522717)
2010
20
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. (19476529)
2009
21
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (20596988)
2009
22
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. (19384064)
2009
23
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. (19215270)
2009
24
Metastatic hidradenocarcinoma: Surgery and chemotherapy. (22666726)
2009
25
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. (20740144)
2009
26
Clear cell hidradenocarcinoma developing in pacemaker pocket. (18950311)
2008
27
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. (17214855)
2007
28
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. (17103407)
2007
29
Hidradenocarcinoma: a histological and immunohistochemical study. (17083691)
2006
30
Metastatic hidradenocarcinoma: efficacy of capecitabine. (17043204)
2006
31
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. (15355375)
2004
32
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. (10955691)
2000
33
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
34
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. (8626149)
1996
35
Metastatic clear-cell hidradenocarcinoma of the vulva. (8428700)
1993
36
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. (2984259)
1985
37
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. (6328124)
1984
38
Eccrine hidradenocarcinoma of the vulva with Paget's disease. Case report with a review of the literature. (6295435)
1983
39
Clear cell hidradenocarcinoma. Report of an unusual case. (190056)
1976
40
Hidradenocarcinoma: report of a case. (4310623)
1969
41
Clear cell hidradenoma and hidradenocarcinoma. (14032110)
1963
42
A clear-cell hidradenocarcinoma with metastases. (13472651)
1957
43
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952

Variations for Hidradenocarcinoma

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Expression for genes affiliated with Hidradenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Hidradenocarcinoma

Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for genes affiliated with Hidradenocarcinoma

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Pathways related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6EGFR, ERBB2
29.6EGFR, ERBB2
3
Show member pathways
9.6ERBB2, EGFR
49.6ERBB2, EGFR
5
Show member pathways
9.6ERBB2, EGFR
69.6ERBB2, EGFR
79.6KRT5, KRT7
8
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway59
9.5EGFR, ESR1
99.5EGFR, ESR1
10
Show member pathways
9.4TP63, TP53
119.4EGFR, TP53
129.3ESR1, TP53
139.3ESR1, TP53
149.3TP53, ESR1
15
Show member pathways
9.1EGFR, ERBB2, ESR1
16
Show member pathways
9.1EGFR, ERBB2, ESR1
17
Show member pathways
Development Ligand independent activation of ESR1 and ESR259
9.1EGFR, ERBB2, ESR1
18
Show member pathways
Signaling Pathways in Glioblastoma37
9.0EGFR, ERBB2, TP53
19
Show member pathways
9.0EGFR, ERBB2, TP53
209.0EGFR, ERBB2, TP53
219.0EGFR, ERBB2, TP53
22
Show member pathways
9.0EGFR, ERBB2, TP53
23
Show member pathways
9.0TP53, ERBB2, EGFR
249.0TP53, ERBB2, EGFR
25
Show member pathways
9.0TP53, ERBB2, EGFR
26
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.0TP53, ERBB2, EGFR
27
Show member pathways
Signal transduction PTEN pathway59
9.0TP53, ERBB2, EGFR
289.0EGFR, TP53, TP63
298.9EGFR, ESR1, TP53
308.6EGFR, ERBB2, TP53, TP63
318.5EGFR, ERBB2, ESR1, TP53
328.5TP53, ESR1, ERBB2, EGFR
33
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.5TP53, ESR1, ERBB2, EGFR
34
Show member pathways
8.5TP53, ESR1, ERBB2, EGFR
35
Show member pathways
8.5TP53, ESR1, ERBB2, EGFR

Compounds for genes affiliated with Hidradenocarcinoma

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Compounds related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1topotecan44 1211.4EGFR
2ag 490609.9ERBB2, EGFR
3jnj 28871063 hydrochloride609.9EGFR, ERBB2
4alkylating agents509.9EGFR, ESR1
5afatinib50 1210.9EGFR, ERBB2
6ag 1478 hydrochloride609.9ERBB2, EGFR
7iressa609.8ERBB2, EGFR
8pd158780449.8ERBB2, EGFR
9ag 1478449.8MUC5AC
10fadrozole449.6ERBB2, ESR1
11anastrozole44 50 1211.5ESR1, ERBB2, EGFR
12exemestane44 50 60 1212.5ESR1, ERBB2, EGFR
13everolimus44 50 1211.5ESR1, ERBB2, EGFR
14lapatinib44 50 1211.5ESR1, ERBB2, EGFR
15fulvestrant44 50 29 1212.5EGFR, ERBB2, ESR1
16letrozole44 50 60 1212.5ESR1, ERBB2, EGFR
17trastuzumab44 50 1211.4ESR1, ERBB2, EGFR
184-hydroxytamoxifen449.4ESR1, ERBB2, EGFR
19suberoylanilide hydroxamic acid449.4TP53, ERBB2, EGFR
20oxaliplatin44 50 1211.4EGFR, ERBB2, TP53
21radicicol44 60 1211.4ERBB2, ESR1, TP53
22flavopiridol44 1210.4EGFR, ERBB2, TP53
23n-(4-hydroxyphenyl)retinamide449.3TP53, ESR1, ERBB2
24bortezomib44 50 1211.3EGFR, ERBB2, TP53
25gefitinib44 50 1211.2ESR1, ERBB2, EGFR
26hematoxylin449.0KRT7, MUC5AC, TP63
27progestin449.0ESR1, ERBB2, EGFR
28irinotecan44 50 1211.0EGFR, ERBB2, TP53
29taxane448.9TP53, ESR1, ERBB2, EGFR
30geldanamycin44 50 60 1211.9EGFR, ERBB2, ESR1, TP53
31docetaxel44 50 60 1211.9EGFR, ERBB2, ESR1, TP53
32genistein44 29 60 3 25 1213.9EGFR, KRT5, ERBB2, ESR1
33tamoxifen44 50 29 1211.9EGFR, ERBB2, ESR1, TP53
34paclitaxel44 50 1210.8TP53, ESR1, ERBB2, EGFR
35ly294002448.8EGFR, ERBB2, ESR1, TP53
36carboplatin44 50 1210.7EGFR, ERBB2, TP53
37methotrexate50 44 1210.6ESR1, MUC5AC, ERBB2, KRT7
38n acetylcysteine448.6EGFR, ERBB2, MUC5AC, TP53
39arginine448.6TP63, TP53, ERBB2, KRT7, KRT5
40doxorubicin44 50 1210.5TP63, TP53, ESR1, ERBB2, EGFR
41cisplatin44 50 60 1211.5TP63, TP53, ESR1, ERBB2, EGFR
425fluorouracil448.1TP53, ESR1, MUC5AC, ERBB2, EGFR
43vegf448.0TP63, TP53, ESR1, ERBB2, KRT7, EGFR
44tyrosine447.9TP63, MUC5AC, ERBB2, KRT7, KRT5, EGFR
45retinoid447.6TP53, ESR1, MUC5AC, KRT7, KRT5, EGFR
46testosterone44 60 25 1210.5TP63, ESR1, MUC5AC, ERBB2, KRT7, KRT5
47retinoic acid44 258.2TP63, TP53, ESR1, MUC5AC, KRT7, KRT5
48paraffin446.9EGFR, TP63, TP53, ESR1, MUC5AC, ERBB2
49progesterone44 29 60 25 1210.9TP63, TP53, ESR1, MUC5AC, ERBB2, KRT7
50estrogen446.8TP63, TP53, ESR1, MUC5AC, ERBB2, KRT7

GO Terms for genes affiliated with Hidradenocarcinoma

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Cellular components related to Hidradenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.4TP53, TP63
2cytoplasmGO:0057377.4EGFR, KRT5, KRT7, ERBB2, TP53, TP63

Biological processes related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell developmentGO:0020649.9ESR1, TP63
2cellular response to estradiol stimulusGO:0713929.8EGFR, ESR1
3mitotic G1 DNA damage checkpointGO:0315719.8TP53, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.8TP63, TP53
5positive regulation of nitric oxide biosynthetic processGO:0454299.7ESR1, EGFR
6response to X-rayGO:0101659.7TP53, TP63
7cell agingGO:0075699.7TP63, TP53
8positive regulation of MAP kinase activityGO:0434069.7ERBB2, EGFR
9response to gamma radiationGO:0103329.7TP53, TP63
10intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.7TP63, TP53
11cellular response to UVGO:0346449.6TP53, TP63
12neuron apoptotic processGO:0514029.6TP53, TP63
13positive regulation of fibroblast proliferationGO:0481469.6EGFR, ESR1
14positive regulation of epithelial cell proliferationGO:0506799.5EGFR, ERBB2
15cellular response to drugGO:0356909.4EGFR, TP53
16chromatin remodelingGO:0063389.2TP63, ESR1
17cell proliferationGO:0082839.2TP53, ERBB2, EGFR
18negative regulation of apoptotic processGO:0430669.0EGFR, TP53, TP63
19positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TP63, TP53, ESR1, EGFR

Molecular functions related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.9ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:0047169.8EGFR, ERBB2
3transmembrane receptor protein tyrosine kinase activityGO:0047149.7EGFR, ERBB2
4nitric-oxide synthase regulator activityGO:0302359.7EGFR, ESR1
5damaged DNA bindingGO:0036849.4TP63, TP53
6RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0010779.4TP53, TP63
7protein phosphatase bindingGO:0199039.3EGFR, ERBB2, TP53
8p53 bindingGO:0020399.1TP53, TP63
9enzyme bindingGO:0198999.0EGFR, ESR1, TP53
10protein heterodimerization activityGO:0469828.9EGFR, ERBB2, TP53
11chromatin bindingGO:0036828.7TP63, TP53, ESR1, EGFR
12identical protein bindingGO:0428028.4EGFR, ERBB2, ESR1, TP53, TP63
13protein bindingGO:0055157.4TP63, TP53, ESR1, ERBB2, KRT7, KRT5

Products for genes affiliated with Hidradenocarcinoma

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Sources for Hidradenocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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47OMIM via Orphanet
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52QIAGEN
57SNOMED-CT via Orphanet
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62UMLS via Orphanet