MCID: HDR006
MIFTS: 38

Hidradenocarcinoma malady

Endocrine category

Summaries for Hidradenocarcinoma

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Hidradenocarcinoma is a tumor caused by the abnormal growth of cells in a sweat gland.  it is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but it has also been found on other parts of the body.  this type of tumor typically develops in older individuals (after age 40).  each hidradenocarcinoma develops differently over time; some may stay the same size and others grow rapidly.  sometimes it may spread into nearby tissues, or to more distant parts of the body in a process called metastasis.  it is not known why some hidradenocarcinomas progress rapidly while others remain stable. last updated: 9/25/2013

MalaCards: Hidradenocarcinoma, also known as sweat gland adenocarcinoma, is related to adenocarcinoma and vulvar clear cell hidradenocarcinoma. An important gene associated with Hidradenocarcinoma is KRT5 (keratin 5), and among its related pathways are Glioma and a6b1 and a6b4 Integrin signaling. The compounds Afatinib and iressa have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and t cells, and related mouse phenotypes are endocrine/exocrine gland and integument.

Wikipedia:64 Hidradenocarcinoma is a cutaneous condition that may develop de novo or in association with an existent... more...

Aliases & Classifications for Hidradenocarcinoma

Sources:
43NIH Rare Diseases, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

hidradenocarcinoma 43
sweat gland adenocarcinoma 61


Related Diseases for Hidradenocarcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.2TP53, TP63, ESR1, ERBB2, KRT7, KRT5
2vulvar clear cell hidradenocarcinoma10.3
3sweat gland carcinoma10.2
4nodular hidradenoma10.2
5clear cell hidradenoma10.0
6syringoma10.0
7colon adenocarcinoma10.0MUC5AC
8cystadenocarcinoma10.0MUC5AC
9wilms tumor10.0KRT7
10cystadenoma10.0KRT7
11mixed cell type cancer10.0KRT7
12synovial sarcoma10.0KRT7
13uterine carcinosarcoma10.0ERBB2
14teratoma10.0KRT7
15thymoma10.0TP63
16nephrogenic adenoma10.0KRT7
17psoriasis10.0KRT5
18thyroid cancer10.0TP53
19oral cavity cancer10.0TP53
20nephroblastoma10.0TP53
21rhabdomyosarcoma10.0TP53
22cervical squamous cell carcinoma10.0TP63
23leukemia10.0TP53
24sertoli-leydig cell tumor10.0KRT7
25ependymoma10.0EGFR
26ulcerative colitis10.0TP53
27myoepithelioma10.0TP63
28neuroblastoma10.0TP53
29giant cell glioblastoma10.0EGFR
30nasopharynx carcinoma10.0TP53
31angiomyolipoma10.0ESR1
32meningioma10.0ESR1
33chordoma10.0KRT7, KRT5
34leiomyoma10.0ESR1
35bilateral breast cancer10.0ESR1
36endometriosis10.0ESR1
37cleft lip10.0TP63
38pancreatic ductal carcinoma10.0MUC5AC, KRT7
39benign mesothelioma10.0TP53, KRT5
40gastritis10.0MUC5AC, TP53
41anaplastic oligodendroglioma10.0EGFR
42renal oncocytoma10.0KRT7
43pseudomyxoma peritonei10.0KRT7, MUC5AC
44breast fibroadenoma10.0ESR1
45cutaneous paget's disease10.0ERBB2, KRT7
46thymic carcinoma10.0TP63, KRT7
47skin cancer10.0TP53, KRT7
48pituitary tumors10.0ESR1
49ovarian cancer10.0ERBB2, KRT7
50familial adenomatous polyposis10.0TP53, MUC5AC

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to hidradenocarcinoma

Clinical Features for Hidradenocarcinoma

Drugs & Therapeutics for Hidradenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Hidradenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Hidradenocarcinoma

Search NIH Clinical Center for Hidradenocarcinoma

Search CenterWatch for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

Anatomical Context for Hidradenocarcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hidradenocarcinoma:

33
Breast, Skin, T cells

Animal Models for Hidradenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hidradenocarcinoma

Sources:
51PubMed
See all sources

Articles related to Hidradenocarcinoma:

(show all 40)
idTitleAuthorsYear
1
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. (23489214)
2013
2
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. (22998159)
2013
3
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. (23466792)
2013
4
Hidradenocarcinoma of the Finger. (23486133)
2013
5
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. (23053773)
2013
6
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. (22678002)
2012
7
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. (23271300)
2012
8
No sweat, a rare case of hidradenocarcinoma. (22369809)
2012
9
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. (21892057)
2011
10
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. (21844475)
2011
11
Hidradenocarcinoma of the fingertip: a case report and literature review. (21489038)
2011
12
Radiotherapy on hidradenocarcinoma. (22540063)
2011
13
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. (21044227)
2010
14
Perianal nodular hidradenocarcinoma. Case report. (20478121)
2010
15
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. (20572504)
2010
16
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. (19522717)
2010
17
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. (19476529)
2009
18
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (20596988)
2009
19
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. (19384064)
2009
20
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. (19215270)
2009
21
Metastatic hidradenocarcinoma: Surgery and chemotherapy. (22666726)
2009
22
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. (20740144)
2009
23
Clear cell hidradenocarcinoma developing in pacemaker pocket. (18950311)
2008
24
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. (17214855)
2007
25
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. (17103407)
2007
26
Hidradenocarcinoma: a histological and immunohistochemical study. (17083691)
2006
27
Metastatic hidradenocarcinoma: efficacy of capecitabine. (17043204)
2006
28
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. (15355375)
2004
29
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. (10955691)
2000
30
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
31
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. (8626149)
1996
32
Metastatic clear-cell hidradenocarcinoma of the vulva. (8428700)
1993
33
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. (2984259)
1985
34
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. (6328124)
1984
35
Eccrine hidradenocarcinoma of the vulva with Paget's disease. Case report with a review of the literature. (6295435)
1983
36
Clear cell hidradenocarcinoma. Report of an unusual case. (190056)
1976
37
Hidradenocarcinoma: report of a case. (4310623)
1969
38
Clear cell hidradenoma and hidradenocarcinoma. (14032110)
1963
39
A clear-cell hidradenocarcinoma with metastases. (13472651)
1957
40
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952

Genetic Variations for Hidradenocarcinoma

Expression for genes affiliated with Hidradenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hidradenocarcinoma

Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for genes affiliated with Hidradenocarcinoma

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 60Tocris Bioscience, 12EMD Millipore, 56SinoBiological, 53R&D Systems, 50PharmGKB
See all sources

Pathways related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9TP53
29.6ERBB2, EGFR
39.6ERBB2, EGFR
4
Hide members
9.6ERBB2, EGFR
5
Hide members
9.5TP53, ERBB2
6
Hide members
9.4TP53, TP63
79.4TP53, TP63
89.4EGFR, TP53
99.3TP53, ESR1
109.3TP53, ESR1
11
Hide members
9.1ESR1, ERBB2, EGFR
12
Development Ligand-independent activation of ESR1 and ESR2
Hide members
9.1ESR1, ERBB2, EGFR
13
Hide members
9.0EGFR, ERBB2, TP53
14
Hide members
9.0EGFR, ERBB2, TP53
159.0EGFR, ERBB2, TP53
169.0TP53, ERBB2, EGFR
17
Hide members
9.0TP53, ERBB2, EGFR
189.0TP53, TP63, EGFR
198.9EGFR, ESR1, TP53
208.6TP53, TP63, ERBB2, EGFR
21
Hide members
8.5EGFR, ERBB2, ESR1, TP53
228.5EGFR, ERBB2, ESR1, TP53
238.5TP53, ESR1, ERBB2, EGFR
24
Hide members
8.5TP53, ESR1, ERBB2, EGFR

Compounds for genes affiliated with Hidradenocarcinoma

Sources:
11DrugBank, 60Tocris Bioscience, 45Novoseek, 50PharmGKB, 29IUPHAR, 2BitterDB, 24HMDB
See all sources

Compounds related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1Afatinib1110.0ERBB2, EGFR
2iressa6010.0ERBB2, EGFR
3pd1587804510.0ERBB2, EGFR
4ag 1478 hydrochloride6010.0ERBB2, EGFR
5ag 4906010.0EGFR, ERBB2
6jnj 28871063 hydrochloride609.9ERBB2, EGFR
7pertuzumab45 50 1111.8EGFR, ERBB2
8fadrozole459.8ESR1, ERBB2
9hrgbeta1459.6ERBB2, EGFR
10anastrozole45 1110.6ESR1, ERBB2, EGFR
11exemestane50 45 60 1112.5EGFR, ESR1, ERBB2
12lapatinib45 50 1111.5ESR1, EGFR, ERBB2
13fulvestrant45 50 29 1112.5ESR1, EGFR, ERBB2
14letrozole45 50 60 1112.5ERBB2, EGFR, ESR1
15trastuzumab45 50 1111.5EGFR, ERBB2, ESR1
16topotecan45 1110.4EGFR, ERBB2, TP53
17suberoylanilide hydroxamic acid459.4EGFR, ERBB2, TP53
184-hydroxytamoxifen459.4ESR1, ERBB2, EGFR
19oxaliplatin45 50 1111.4TP53, ERBB2, EGFR
20flavopiridol45 1110.4TP53, ERBB2, EGFR
21radicicol45 60 1111.4TP53, ERBB2, ESR1
22n-(4-hydroxyphenyl)retinamide459.4ERBB2, ESR1, TP53
23pki-166459.3ERBB2, EGFR
24bortezomib45 1110.3TP53, ERBB2, EGFR
25gefitinib45 50 1111.3ESR1, EGFR, ERBB2
26irinotecan45 50 1111.3EGFR, TP53, ERBB2
27progestin459.2EGFR, ERBB2, ESR1
28carboplatin45 50 1111.1EGFR, TP53, ERBB2
29hematoxylin459.1KRT7, MUC5AC, TP63
30ag 1478459.0EGFR, MUC5AC, ERBB2
31taxane458.9ERBB2, ESR1, TP53, EGFR
32geldanamycin45 50 60 1111.9TP53, EGFR, ESR1, ERBB2
33gemcitabine45 50 1110.9EGFR, TP53, ERBB2
34docetaxel45 50 60 1111.9TP53, EGFR, ERBB2, ESR1
35tamoxifen45 50 29 1111.9ESR1, TP53, ERBB2, EGFR
36paclitaxel45 50 1110.9TP53, EGFR, ERBB2, ESR1
37ly294002458.8ESR1, ERBB2, EGFR, TP53
38genistein45 29 60 2 11 2413.8ERBB2, EGFR, ESR1, KRT5
39methotrexate45 50 1110.6ESR1, ERBB2, MUC5AC, KRT7
40n acetylcysteine458.6EGFR, MUC5AC, ERBB2, TP53
41arginine458.6TP63, KRT5, KRT7, TP53, ERBB2
42doxorubicin45 50 1110.5TP53, EGFR, ERBB2, TP63, ESR1
435fluorouracil458.1TP53, ESR1, ERBB2, MUC5AC, EGFR
44vegf458.0KRT7, ERBB2, TP63, TP53, EGFR, ESR1
45tyrosine457.8KRT5, TP63, KRT7, MUC5AC, EGFR, ERBB2
46retinoid457.6EGFR, MUC5AC, KRT5, KRT7, ESR1, TP53
47testosterone45 60 11 2410.5ESR1, KRT5, TP63, ERBB2, KRT7, EGFR
48retinoic acid45 248.2EGFR, ESR1, TP53, TP63, MUC5AC, KRT5
49paraffin456.9EGFR, ERBB2, TP63, KRT7, KRT5, MUC5AC
50progesterone45 60 29 11 2410.9KRT5, KRT7, ERBB2, ESR1, TP63, TP53

GO Terms for genes affiliated with Hidradenocarcinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell developmentGO:0020649.8TP63, ESR1
2cellular response to estradiol stimulusGO:0713929.7ESR1, EGFR
3mitotic G1 DNA damage checkpointGO:0315719.7TP63, TP53
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.7TP53, TP63
5response to X-rayGO:0101659.7TP63, TP53
6positive regulation of MAP kinase activityGO:0434069.6ERBB2, EGFR
7intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.6TP53, TP63
8cell agingGO:0075699.6TP63, TP53
9response to gamma radiationGO:0103329.6TP53, TP63
10neuron apoptotic processGO:0514029.5TP63, TP53
11positive regulation of nitric oxide biosynthetic processGO:0454299.5ESR1, EGFR
12cellular response to UVGO:0346449.3TP53, TP63
13positive regulation of fibroblast proliferationGO:0481469.2EGFR, ESR1
14positive regulation of transcription from RNA polymerase II promoterGO:0459448.7ESR1, TP53, EGFR, TP63

Molecular functions related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.8EGFR, ERBB2
2receptor signaling protein tyrosine kinase activityGO:0047169.6EGFR, ERBB2
3nitric-oxide synthase regulator activityGO:0302359.6EGFR, ESR1
4transmembrane receptor protein tyrosine kinase activityGO:0047149.3EGFR, ERBB2
5enzyme bindingGO:0198998.8EGFR, ESR1, TP53
6chromatin bindingGO:0036828.6TP53, TP63, ESR1, EGFR
7identical protein bindingGO:0428028.3EGFR, ERBB2, ESR1, TP63, TP53
8protein bindingGO:0055157.2EGFR, KRT5, KRT7, ESR1, TP63, TP53

Products for genes affiliated with Hidradenocarcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hidradenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet