MCID: HDR006
MIFTS: 38

Hidradenocarcinoma malady

Rare diseases, Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Hidradenocarcinoma

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Aliases & Descriptions for Hidradenocarcinoma:

Name: Hidradenocarcinoma 45
Primary Mucoepidermoid Cutaneous Carcinoma 45
Malignant Nodular/clear Cell Hidradenoma 45
Malignant Clear Cell Acrospiroma 45
 
Clear Cell Eccrine Carcinoma 45
Sweat Gland Adenocarcinoma 65
Eccrine Ductal Carcinoma 65
Malignant Acrospiroma 45


Classifications:



Summaries for Hidradenocarcinoma

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NIH Rare Diseases:45 Hidradenocarcinoma is a tumor caused by the abnormal growth of cells in a sweat gland.  it is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but it has also been found on other parts of the body.  this type of tumor typically develops in older individuals (after age 40).  each hidradenocarcinoma develops differently over time; some may stay the same size and others grow rapidly.  sometimes it may spread into nearby tissues, or to more distant parts of the body in a process called metastasis.  it is not known why some hidradenocarcinomas progress rapidly while others remain stable. last updated: 9/25/2013

MalaCards based summary: Hidradenocarcinoma, also known as primary mucoepidermoid cutaneous carcinoma, is related to malignant acrospiroma and acrospiroma. An important gene associated with Hidradenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways are Central carbon metabolism in cancer and Akt Signaling Pathway. Affiliated tissues include skin and lymph node, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Wikipedia:68 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Related Diseases for Hidradenocarcinoma

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Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 259)
idRelated DiseaseScoreTop Affiliating Genes
1malignant acrospiroma10.6
2acrospiroma10.5
3hidradenoma10.4
4vulvar clear cell hidradenocarcinoma10.4
5heart leiomyosarcoma10.4ERBB2, ESR1
6glaucoma iridogoniodysgenesia10.4ERBB2, ESR1
7breast metaplastic carcinoma10.4EGFR, ERBB2
8epidermolytic acanthoma10.4ERBB2, PIP
9molluscum contagiosum10.3ERBB2, KRT5
10enophthalmos10.3EGFR, ERBB2
11breast mucinous carcinoma10.3ERBB2, KRT5
12vulva basal cell carcinoma10.3KRT7, TP63
13estrogen-receptor negative breast cancer10.3EGFR, ERBB2
14ciliary body disease10.3ERBB2, ESR1
15pilar sheath acanthoma10.3KRT5, KRT7
16crohn's colitis10.3KRT7, PIP
17gastric adenosquamous carcinoma10.3KRT5, TP53
18thyroid hyalinizing trabecular adenoma10.3KRT7, MUC5AC
19anus cancer10.3KRT7, MUC5AC
20malignant cystic nephroma10.3EGFR, ERBB2, ESR1
21anus lymphoma10.3ESR1, TP63
22papillary extrahepatic bile duct adenocarcinoma10.3ERBB2, ESR1
23esophageal adenoid cystic carcinoma10.3EGFR, ERBB2, ESR1
24congenital disorder of glycosylation, type if10.3ERBB2, TP53
25gastric papillary adenocarcinoma10.3ERBB2, ESR1, KRT5
26metachronous kidney wilms' tumor10.3ESR1, TP53
27bronchial disease10.3EGFR, ERBB2, KRT5
28follicular dendritic cell sarcoma10.3EGFR, ERBB2, ESR1
29scrotum paget's disease10.3EGFR, ERBB2, ESR1
30her2-receptor positive breast cancer10.3EGFR, ERBB2, ESR1
31bilirubin metabolic disorder10.3EGFR, ERBB2
32chronic atticoantral disease10.3ERBB2, TP53
33pagod syndrome10.3ERBB2, KRT7, PIP
34factor xiii deficiency10.3KRT7, PIP
35eccrine mixed tumor of skin10.3ESR1, KRT7, PIP
36vulvar trichoepithelioma10.3ERBB2, KRT7, PIP
37vulva cancer10.3ERBB2, KRT7, PIP
38anus rhabdomyosarcoma10.3KRT5, KRT7, TP63
39malignant hypertension10.3S100B, TP53
40microscopic colitis10.3EGFR, ERBB2, S100B
41uterine corpus cellular leiomyoma10.3ERBB2, ESR1, TP53
42mild hemophilia a10.3MUC2, MUC5AC
43scrotum basal cell carcinoma10.3EGFR, ERBB2, S100B
44leukemoid reaction10.2KRT5, KRT7, PIP
45third-degree atrioventricular block10.2MKI67, MUC5AC
46familial renal papillary carcinoma10.2EGFR, ERBB2, TP53
47nodular hidradenoma10.2
48breast cyst10.2ERBB2, ESR1, TP53
49peritoneal cystic mesothelioma10.2EGFR, ERBB2, TP53
50uterine corpus cancer10.2ERBB2, TP53

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to hidradenocarcinoma

Symptoms for Hidradenocarcinoma

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Drugs & Therapeutics for Hidradenocarcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

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Anatomical Context for Hidradenocarcinoma

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MalaCards organs/tissues related to Hidradenocarcinoma:

33
Skin, Lymph node

Animal Models for Hidradenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Hidradenocarcinoma:

38 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0CDX2, EGFR, ERBB2, ESR1, KRT5, TP53
2MP:00053828.8BCL2, CCND1, EGFR, ERBB2, KRT5, TP53
3MP:00053698.8BCL2, EGFR, ERBB2, ESR1, TP53, TP63
4MP:00053908.4CCND1, CDX2, EGFR, ERBB2, ESR1, NKX2-1
5MP:00107718.0BCL2, CCND1, EGFR, ERBB2, ESR1, KRT5
6MP:00053887.8BCL2, CCND1, EGFR, ERBB2, ESR1, NKX2-1
7MP:00020067.4BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
8MP:00053867.4BCL2, CCND1, ERBB2, ESR1, KRT5, NKX2-1
9MP:00053787.1BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
10MP:00107686.9BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
11MP:00053796.7BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
12MP:00053876.6BCL2, CCND1, EGFR, ESR1, MUC2, MUC5AC
13MP:00053856.5BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
14MP:00053766.3BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
15MP:00053816.3BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
16MP:00053896.2BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
17MP:00053845.8BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1

Publications for Hidradenocarcinoma

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Articles related to Hidradenocarcinoma:

(show all 44)
idTitleAuthorsYear
1
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. (25627632)
2015
2
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. (25815059)
2015
3
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. (25513929)
2014
4
Hidradenocarcinoma of the chest. (25382529)
2014
5
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. (25006935)
2014
6
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. (24490986)
2014
7
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. (23489214)
2013
8
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. (22998159)
2013
9
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. (23466792)
2013
10
Hidradenocarcinoma of the Finger. (23486133)
2013
11
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. (23053773)
2013
12
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. (23271300)
2012
13
No sweat, a rare case of hidradenocarcinoma. (22369809)
2012
14
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. (21844475)
2011
15
Hidradenocarcinoma of the fingertip: a case report and literature review. (21489038)
2011
16
Radiotherapy on hidradenocarcinoma. (22540063)
2011
17
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. (21044227)
2010
18
Perianal nodular hidradenocarcinoma. Case report. (20478121)
2010
19
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. (20572504)
2010
20
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. (19522717)
2010
21
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. (19476529)
2009
22
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (20596988)
2009
23
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. (19384064)
2009
24
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. (19215270)
2009
25
Metastatic hidradenocarcinoma: Surgery and chemotherapy. (22666726)
2009
26
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. (20740144)
2009
27
Clear cell hidradenocarcinoma developing in pacemaker pocket. (18950311)
2008
28
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. (17214855)
2007
29
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. (17103407)
2007
30
Hidradenocarcinoma: a histological and immunohistochemical study. (17083691)
2006
31
Metastatic hidradenocarcinoma: efficacy of capecitabine. (17043204)
2006
32
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. (15355375)
2004
33
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. (10955691)
2000
34
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
35
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. (8626149)
1996
36
Metastatic clear-cell hidradenocarcinoma of the vulva. (8428700)
1993
37
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. (2984259)
1985
38
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. (6328124)
1984
39
Eccrine hidradenocarcinoma of the vulva with Paget's disease. Case report with a review of the literature. (6295435)
1983
40
Clear cell hidradenocarcinoma. Report of an unusual case. (190056)
1976
41
Hidradenocarcinoma: report of a case. (4310623)
1969
42
Clear cell hidradenoma and hidradenocarcinoma. (14032110)
1963
43
A clear-cell hidradenocarcinoma with metastases. (13472651)
1957
44
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952

Variations for Hidradenocarcinoma

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Expression for genes affiliated with Hidradenocarcinoma

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Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for genes affiliated with Hidradenocarcinoma

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Pathways related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7EGFR, ERBB2, TP53
29.7EGFR, ERBB2, TP53
39.7EGFR, ERBB2, TP53
4
Show member pathways
9.6BCL2, TP53, TP63
5
Show member pathways
9.6EGFR, ERBB2, VIM
6
Show member pathways
9.5CCND1, EGFR, ESR1
79.5CCND1, EGFR, ESR1
89.4BCL2, CCND1, ERBB2
9
Show member pathways
9.4BCL2, EGFR, ERBB2, TP53
109.3BCL2, EGFR, TP53, TP63
119.3BCL2, CCND1, TP53
12
Show member pathways
9.3CCND1, EGFR, ERBB2, ESR1
139.2CCND1, EGFR, ERBB2, TP53
14
Show member pathways
9.2CCND1, EGFR, ERBB2, TP53
15
Show member pathways
9.2CCND1, EGFR, ERBB2, TP53
16
Wnt Signaling Pathway (WikiPathways)
Show member pathways
9.1CCND1, EGFR, ERBB2, TP53
179.0CCND1, EGFR, ERBB2, ESR1, TP53
189.0CCND1, EGFR, TP53, VIM
198.8BCL2, CCND1, EGFR, ERBB2, TP53
20
Show member pathways
8.8BCL2, CCND1, EGFR, ERBB2, TP53
21
Show member pathways
8.8BCL2, CCND1, EGFR, ERBB2, TP53
228.8BCL2, CCND1, EGFR, ESR1, TP53
238.7CCND1, MKI67, TP53, TP63, VIM
248.6BCL2, CCND1, EGFR, ERBB2, ESR1, TP53
258.1BCL2, CCND1, EGFR, ERBB2, TP53, TP63

GO Terms for genes affiliated with Hidradenocarcinoma

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Cellular components related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00057375.7BCL2, CCND1, EGFR, ERBB2, ESR1, KRT5
2nucleusGO:00056345.1BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1

Biological processes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell developmentGO:000206410.6ESR1, TP63
2cerebral cortex cell migrationGO:002179510.6EGFR, NKX2-1
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.5TP53, TP63
4B cell lineage commitmentGO:000232610.4BCL2, TP53
5T cell lineage commitmentGO:000236010.4BCL2, TP53
6response to UV-AGO:007014110.4CCND1, EGFR
7regulation of mitochondrial membrane permeabilityGO:004690210.4BCL2, TP53
8Leydig cell differentiationGO:003332710.2CCND1, NKX2-1
9cell agingGO:000756910.1BCL2, TP53, TP63
10response to gamma radiationGO:001033210.1BCL2, TP53, TP63
11neuron apoptotic processGO:005140210.1BCL2, TP53, TP63
12pattern specification processGO:000738910.0CDX2, NKX2-1, TP63
13response to X-rayGO:001016510.0CCND1, TP53, TP63
14response to glucocorticoidGO:00513849.7BCL2, CCND1, S100B
15mitotic G1 DNA damage checkpointGO:00315719.4CCND1, TP53, TP63
16organ morphogenesisGO:00098879.4BCL2, CDX2, NKX2-1, TP63
17negative regulation of apoptotic processGO:00430669.3BCL2, EGFR, ERBB2, TP53, TP63
18positive regulation of transcription, DNA-templatedGO:00458939.2CDX2, ESR1, NKX2-1, TP53, TP63
19cellular response to DNA damage stimulusGO:00069749.0BCL2, CCND1, TP53, TP63
20cell proliferationGO:00082838.8BCL2, EGFR, ERBB2, MKI67, S100B, TP53
21positive regulation of gene expressionGO:00106288.5NKX2-1, PIP, TP53, VIM
22positive regulation of cell proliferationGO:00082848.4BCL2, CCND1, CDX2, EGFR, ERBB2, S100B

Molecular functions related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:000471610.7EGFR, ERBB2
2nitric-oxide synthase regulator activityGO:003023510.7EGFR, ESR1
3protein phosphatase bindingGO:00199039.9BCL2, EGFR, ERBB2, TP53
4ubiquitin protein ligase bindingGO:00316259.9BCL2, EGFR, ERBB2, TP53
5glycoprotein bindingGO:00019489.8ERBB2, PIP, VIM
6double-stranded DNA bindingGO:00036909.8CDX2, EGFR, TP53, TP63
7transcription factor bindingGO:00081349.5BCL2, CCND1, ESR1, TP53
8enzyme bindingGO:00198999.2CCND1, EGFR, ESR1, NKX2-1, TP53
9sequence-specific DNA bindingGO:00435658.6BCL2, CDX2, ESR1, NKX2-1, TP53, TP63
10identical protein bindingGO:00428028.5BCL2, EGFR, ERBB2, ESR1, S100B, TP53
11protein bindingGO:00055153.8BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1

Sources for Hidradenocarcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet