MCID: HDR006
MIFTS: 49

Hidradenocarcinoma malady

Rare diseases, Endocrine diseases, Cancer diseases categories

Summaries for Hidradenocarcinoma

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NIH Rare Diseases:43 Hidradenocarcinoma is a tumor caused by the abnormal growth of cells in a sweat gland.  it is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but it has also been found on other parts of the body.  this type of tumor typically develops in older individuals (after age 40).  each hidradenocarcinoma develops differently over time; some may stay the same size and others grow rapidly.  sometimes it may spread into nearby tissues, or to more distant parts of the body in a process called metastasis.  it is not known why some hidradenocarcinomas progress rapidly while others remain stable. last updated: 9/25/2013

MalaCards based summary: Hidradenocarcinoma, also known as clear cell eccrine carcinoma, is related to acrospiroma and hidradenoma. An important gene associated with Hidradenocarcinoma is KRT5 (keratin 5), and among its related pathways are Alzheimers Disease Pathway and Adherens junction. The compounds topotecan and afatinib have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lymph node, and related mouse phenotypes are craniofacial and no phenotypic analysis.

Wikipedia:65 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Aliases & Classifications for Hidradenocarcinoma

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Hidradenocarcinoma, Aliases & Descriptions:

Name: Hidradenocarcinoma 43
Clear Cell Eccrine Carcinoma 43 62
Malignant Acrospiroma 43 62
Primary Mucoepidermoid Cutaneous Carcinoma 43
 
Malignant Nodular/clear Cell Hidradenoma 43
Malignant Clear Cell Acrospiroma 43
Sweat Gland Adenocarcinoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Related Diseases for Hidradenocarcinoma

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Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1acrospiroma10.5
2hidradenoma10.3
3vulvar clear cell hidradenocarcinoma10.3
4sweat gland carcinoma10.2
5nephrogenic adenoma10.1KRT7
6malignant acrospiroma10.0
7clear cell hidradenoma10.0
8nodular hidradenoma10.0
9eccrine porocarcinoma10.0
10pyogenic granuloma10.0
11giant cell glioblastoma10.0EGFR
12pseudomyxoma peritonei10.0KRT7, MUC5AC
13pancreatic ductal carcinoma10.0KRT7, MUC5AC
14breast fibroadenoma10.0ESR1
15meningioma, familial10.0ESR1
16paget disease, extramammary10.0KRT7, ERBB2
17chordoma10.0KRT5, KRT7
18gallbladder cancer10.0MUC5AC, KRT7
19benign mesothelioma10.0KRT5, TP53
20thymic carcinoma10.0KRT7, TP63
21hypertrophic scars10.0TP63, KRT5
22actinic keratosis10.0TP63, TP53
23stomach cancer10.0ERBB2, TP53
24oxyphilic adenoma10.0KRT7, TP63
25skin benign neoplasm10.0TP63, KRT5
26biliary tract neoplasm10.0ERBB2, EGFR
27pleomorphic adenoma10.0ERBB2, TP63
28neuroendocrine tumor10.0TP63, KRT7
29barrett esophagus/esophageal adenocarcinoma10.0MUC5AC, KRT7, TP53
30brain cancer10.0EGFR, TP53
31leiomyosarcoma10.0TP53, TP63
32mesothelioma, somatic10.0KRT7, KRT5, TP63
33gastritis10.0MUC5AC, TP53
34mesothelioma10.0KRT5, KRT7
35laryngeal carcinoma10.0EGFR, TP53
36breast disease10.0ESR1, ERBB2
37cribriform carcinoma10.0ESR1, TP63
38bronchiolo-alveolar adenocarcinoma10.0KRT7, MUC5AC, EGFR
39abrikosov's tumor10.0ESR1, KRT7
40bladder cancer, somatic10.0ERBB2, TP53
41malignant mixed mullerian tumor10.0ERBB2, TP53, KRT7
42salivary gland adenoid cystic carcinoma10.0KRT7, TP63, ERBB2
43grade iii astrocytoma10.0EGFR, TP53
44papilloma10.0KRT5, TP53, TP63
45li-fraumeni syndrome10.0ESR1, ERBB2
46pancreatic cancer10.0EGFR, MUC5AC, KRT7
47basal cell carcinoma10.0KRT7, TP53, TP63
48esophageal cancer10.0EGFR, TP53
49oral cancer10.0EGFR, TP53, KRT5
50squamous cell carcinoma, head and neck10.0KRT5, EGFR, TP53

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to hidradenocarcinoma

Symptoms for Hidradenocarcinoma

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Drugs & Therapeutics for Hidradenocarcinoma

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Drug clinical trials:

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Search NIH Clinical Center for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

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Anatomical Context for Hidradenocarcinoma

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MalaCards organs/tissues related to Hidradenocarcinoma:

33
Skin, Breast, Lymph node

Animal Models for Hidradenocarcinoma or affiliated genes

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Publications for Hidradenocarcinoma

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Articles related to Hidradenocarcinoma:

(show all 45)
idTitleAuthorsYear
1
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. (25627632)
2015
2
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. (25815059)
2015
3
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. (25513929)
2014
4
Hidradenocarcinoma of the chest. (25382529)
2014
5
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. (25006935)
2014
6
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. (24490986)
2014
7
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. (23489214)
2013
8
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. (22998159)
2013
9
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. (23466792)
2013
10
Hidradenocarcinoma of the Finger. (23486133)
2013
11
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. (23053773)
2013
12
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. (22678002)
2012
13
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. (23271300)
2012
14
No sweat, a rare case of hidradenocarcinoma. (22369809)
2012
15
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. (21892057)
2011
16
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. (21844475)
2011
17
Hidradenocarcinoma of the fingertip: a case report and literature review. (21489038)
2011
18
Radiotherapy on hidradenocarcinoma. (22540063)
2011
19
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. (21044227)
2010
20
Perianal nodular hidradenocarcinoma. Case report. (20478121)
2010
21
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. (20572504)
2010
22
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. (19522717)
2010
23
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. (19476529)
2009
24
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (20596988)
2009
25
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. (19384064)
2009
26
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. (19215270)
2009
27
Metastatic hidradenocarcinoma: Surgery and chemotherapy. (22666726)
2009
28
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. (20740144)
2009
29
Clear cell hidradenocarcinoma developing in pacemaker pocket. (18950311)
2008
30
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. (17214855)
2007
31
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. (17103407)
2007
32
Hidradenocarcinoma: a histological and immunohistochemical study. (17083691)
2006
33
Metastatic hidradenocarcinoma: efficacy of capecitabine. (17043204)
2006
34
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. (15355375)
2004
35
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. (10955691)
2000
36
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
37
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. (8626149)
1996
38
Metastatic clear-cell hidradenocarcinoma of the vulva. (8428700)
1993
39
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. (6328124)
1984
40
Eccrine hidradenocarcinoma of the vulva with Paget's disease. Case report with a review of the literature. (6295435)
1983
41
Clear cell hidradenocarcinoma. Report of an unusual case. (190056)
1976
42
Hidradenocarcinoma: report of a case. (4310623)
1969
43
Clear cell hidradenoma and hidradenocarcinoma. (14032110)
1963
44
A clear-cell hidradenocarcinoma with metastases. (13472651)
1957
45
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952

Variations for Hidradenocarcinoma

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Expression for genes affiliated with Hidradenocarcinoma

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Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for genes affiliated with Hidradenocarcinoma

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Pathways related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6EGFR, ERBB2
29.6EGFR, ERBB2
3
Show member pathways
9.6ERBB2, EGFR
49.6ERBB2, EGFR
5
Show member pathways
9.6ERBB2, EGFR
69.6ERBB2, EGFR
79.6KRT5, KRT7
8
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.5EGFR, ESR1
99.5EGFR, ESR1
10
Show member pathways
9.4TP63, TP53
119.4EGFR, TP53
129.3ESR1, TP53
139.3ESR1, TP53
149.3TP53, ESR1
15
Show member pathways
9.1EGFR, ERBB2, ESR1
16
Show member pathways
9.1EGFR, ERBB2, ESR1
17
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.1EGFR, ERBB2, ESR1
18
Show member pathways
Signaling Pathways in Glioblastoma38
9.0EGFR, ERBB2, TP53
19
Show member pathways
9.0EGFR, ERBB2, TP53
209.0EGFR, ERBB2, TP53
219.0EGFR, ERBB2, TP53
22
Show member pathways
9.0EGFR, ERBB2, TP53
23
Show member pathways
9.0TP53, ERBB2, EGFR
249.0TP53, ERBB2, EGFR
25
Show member pathways
9.0TP53, ERBB2, EGFR
26
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.0TP53, ERBB2, EGFR
27
Show member pathways
Signal transduction PTEN pathway60
9.0TP53, ERBB2, EGFR
289.0EGFR, TP53, TP63
298.9EGFR, ESR1, TP53
308.6EGFR, ERBB2, TP53, TP63
318.5EGFR, ERBB2, ESR1, TP53
328.5TP53, ESR1, ERBB2, EGFR
33
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.5TP53, ESR1, ERBB2, EGFR
34
Show member pathways
8.5TP53, ESR1, ERBB2, EGFR
35
Show member pathways
8.5TP53, ESR1, ERBB2, EGFR

Compounds for genes affiliated with Hidradenocarcinoma

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Compounds related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1topotecan45 1311.4EGFR
2afatinib51 1310.9EGFR, ERBB2
3jnj 28871063 hydrochloride619.9EGFR, ERBB2
4alkylating agents519.9EGFR, ESR1
5ag 490619.9ERBB2, EGFR
6ag 1478 hydrochloride619.9EGFR, ERBB2
7iressa619.8ERBB2, EGFR
8pd158780459.8ERBB2, EGFR
9ag 1478459.8MUC5AC
10pertuzumab45 51 1311.6ERBB2, EGFR
11exemestane45 51 61 1312.5EGFR, ERBB2, ESR1
12anastrozole45 51 1311.5EGFR, ERBB2, ESR1
13everolimus45 51 1311.5EGFR, ERBB2, ESR1
14lapatinib45 51 1311.5ESR1, ERBB2, EGFR
15fulvestrant45 51 30 1312.5EGFR, ESR1, ERBB2
16letrozole45 51 61 1312.5EGFR, ERBB2, ESR1
17trastuzumab45 51 1311.4ERBB2, ESR1, EGFR
184-hydroxytamoxifen459.4ESR1, EGFR, ERBB2
19suberoylanilide hydroxamic acid459.4EGFR, ERBB2, TP53
20oxaliplatin45 51 1311.4ERBB2, TP53, EGFR
21radicicol45 61 1311.4ERBB2, ESR1, TP53
22flavopiridol45 1310.4TP53, EGFR, ERBB2
23n-(4-hydroxyphenyl)retinamide459.3TP53, ERBB2, ESR1
24bortezomib45 51 1311.3TP53, EGFR, ERBB2
25gefitinib45 51 1311.2ERBB2, EGFR, ESR1
26hematoxylin459.0MUC5AC, TP63, KRT7
27irinotecan45 51 1311.0EGFR, ERBB2, TP53
28progestin459.0EGFR, ERBB2, ESR1
29taxane458.9ESR1, ERBB2, EGFR, TP53
30geldanamycin45 51 61 1311.9TP53, ESR1, EGFR, ERBB2
31docetaxel45 51 61 1311.9TP53, ESR1, EGFR, ERBB2
32genistein45 30 61 3 26 1313.9KRT5, EGFR, ERBB2, ESR1
33tamoxifen45 51 30 1311.9EGFR, ESR1, TP53, ERBB2
34paclitaxel45 51 1310.8ERBB2, EGFR, ESR1, TP53
35ly294002458.8EGFR, TP53, ESR1, ERBB2
36carboplatin45 51 1310.7ERBB2, TP53, EGFR
37methotrexate51 45 1310.6MUC5AC, ERBB2, KRT7, ESR1
38n acetylcysteine458.6TP53, MUC5AC, ERBB2, EGFR
39arginine458.6TP53, KRT7, KRT5, ERBB2, TP63
40doxorubicin45 51 1310.5EGFR, ERBB2, TP63, ESR1, TP53
41cisplatin45 51 61 1311.5EGFR, ERBB2, ESR1, TP53, TP63
425fluorouracil458.1TP53, ESR1, MUC5AC, ERBB2, EGFR
43vegf458.0TP63, TP53, ESR1, ERBB2, KRT7, EGFR
44tyrosine457.9KRT7, EGFR, KRT5, MUC5AC, TP63, ERBB2
45retinoid457.6KRT5, MUC5AC, ESR1, EGFR, KRT7, TP53
46testosterone45 61 26 1310.5TP63, ESR1, MUC5AC, ERBB2, KRT7, KRT5
47retinoic acid45 268.2ESR1, MUC5AC, TP63, KRT7, EGFR, TP53
48paraffin456.9EGFR, TP63, TP53, ESR1, MUC5AC, ERBB2
49progesterone45 30 61 26 1310.9ESR1, TP53, TP63, EGFR, ERBB2, KRT7
50estrogen456.8TP63, TP53, ESR1, MUC5AC, EGFR, KRT5

GO Terms for genes affiliated with Hidradenocarcinoma

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Cellular components related to Hidradenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:00007859.4TP53, TP63
2cytoplasmGO:00057377.4EGFR, KRT5, KRT7, ERBB2, TP53, TP63

Biological processes related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell developmentGO:00020649.9ESR1, TP63
2cellular response to estradiol stimulusGO:00713929.8EGFR, ESR1
3mitotic G1 DNA damage checkpointGO:00315719.8TP53, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.8TP63, TP53
5positive regulation of nitric oxide biosynthetic processGO:00454299.7ESR1, EGFR
6response to X-rayGO:00101659.7TP53, TP63
7cell agingGO:00075699.7TP63, TP53
8positive regulation of MAP kinase activityGO:00434069.7ERBB2, EGFR
9response to gamma radiationGO:00103329.7TP53, TP63
10intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.7TP63, TP53
11cellular response to UVGO:00346449.6TP53, TP63
12neuron apoptotic processGO:00514029.6TP53, TP63
13positive regulation of fibroblast proliferationGO:00481469.6EGFR, ESR1
14positive regulation of epithelial cell proliferationGO:00506799.5EGFR, ERBB2
15cellular response to drugGO:00356909.4EGFR, TP53
16chromatin remodelingGO:00063389.2TP63, ESR1
17cell proliferationGO:00082839.2TP53, ERBB2, EGFR
18negative regulation of apoptotic processGO:00430669.0EGFR, TP53, TP63
19positive regulation of transcription from RNA polymerase II promoterGO:00459448.8TP63, TP53, ESR1, EGFR

Molecular functions related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00050069.9ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:00047169.8EGFR, ERBB2
3transmembrane receptor protein tyrosine kinase activityGO:00047149.7EGFR, ERBB2
4nitric-oxide synthase regulator activityGO:00302359.7EGFR, ESR1
5damaged DNA bindingGO:00036849.4TP63, TP53
6RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:00010779.4TP53, TP63
7protein phosphatase bindingGO:00199039.3EGFR, ERBB2, TP53
8p53 bindingGO:00020399.1TP53, TP63
9enzyme bindingGO:00198999.0EGFR, ESR1, TP53
10protein heterodimerization activityGO:00469828.9EGFR, ERBB2, TP53
11chromatin bindingGO:00036828.7TP63, TP53, ESR1, EGFR
12identical protein bindingGO:00428028.4EGFR, ERBB2, ESR1, TP53, TP63
13protein bindingGO:00055157.4TP63, TP53, ESR1, ERBB2, KRT7, KRT5

Products for genes affiliated with Hidradenocarcinoma

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Sources for Hidradenocarcinoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet