MCID: HDR006
MIFTS: 49

Hidradenocarcinoma malady

Rare diseases, Endocrine diseases, Cancer diseases categories
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Summaries for Hidradenocarcinoma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Hidradenocarcinoma is a tumor caused by the abnormal growth of cells in a sweat gland.  it is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but it has also been found on other parts of the body.  this type of tumor typically develops in older individuals (after age 40).  each hidradenocarcinoma develops differently over time; some may stay the same size and others grow rapidly.  sometimes it may spread into nearby tissues, or to more distant parts of the body in a process called metastasis.  it is not known why some hidradenocarcinomas progress rapidly while others remain stable. last updated: 9/25/2013

MalaCards: Hidradenocarcinoma, also known as primary mucoepidermoid cutaneous carcinoma, is related to malignant acrospiroma and acrospiroma. An important gene associated with Hidradenocarcinoma is KRT5 (keratin 5), and among its related pathways are Alzheimers Disease Pathway and a6b1 and a6b4 Integrin signaling. The compounds topotecan and afatinib have been mentioned in the context of this disorder. Affiliated tissues include skin and breast, and related mouse phenotypes are craniofacial and no phenotypic analysis.

Wikipedia:65 Hidradenocarcinoma is a cutaneous condition that may develop de novo or in association with an existent... more...

Aliases & Classifications for Hidradenocarcinoma

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

hidradenocarcinoma 43
primary mucoepidermoid cutaneous carcinoma 43
malignant nodular/clear cell hidradenoma 43
malignant clear cell acrospiroma 43
clear cell eccrine carcinoma 43
sweat gland adenocarcinoma 62
malignant acrospiroma 43


Related Diseases for Hidradenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1malignant acrospiroma10.6
2acrospiroma10.5
3hidradenoma10.4
4vulvar clear cell hidradenocarcinoma10.3
5nodular hidradenoma10.2
6eccrine porocarcinoma10.1
7sweat gland carcinoma10.1
8nephrogenic adenoma10.1KRT7
9giant cell glioblastoma10.1EGFR
10pseudomyxoma peritonei10.1KRT7, MUC5AC
11pancreatic ductal carcinoma10.1MUC5AC, KRT7
12breast fibroadenoma10.1ESR1
13meningioma10.1ESR1
14cutaneous paget's disease10.1ERBB2, KRT7
15chordoma10.1KRT5, KRT7
16gallbladder cancer10.1KRT7, MUC5AC
17thymus cancer10.1TP63, KRT7
18hypertrophic scars10.0TP63, KRT5
19stomach cancer10.0TP53, ERBB2
20actinic keratosis10.0TP63, TP53
21clear cell hidradenoma10.0
22skin benign neoplasm10.0KRT5, TP63
23neuroendocrine carcinoma10.0TP63, KRT7
24biliary tract neoplasm10.0EGFR, ERBB2
25pleomorphic adenoma10.0ERBB2, TP63
26oxyphilic adenoma10.0TP63, KRT7
27barrett's esophagus10.0TP53, MUC5AC, KRT7
28brain cancer10.0EGFR, TP53
29leiomyosarcoma10.0TP63, TP53
30malignant mesothelioma10.0TP63, KRT7, KRT5
31gastritis10.0MUC5AC, TP53
32male breast cancer10.0ESR1, ERBB2
33laryngeal benign neoplasm10.0TP53, EGFR
34benign mesothelioma10.0KRT5, KRT7
35cribriform carcinoma10.0TP63, ESR1
36bronchiolo-alveolar adenocarcinoma10.0MUC5AC, KRT7, EGFR
37abrikosov's tumor10.0KRT7, ESR1
38bladder carcinoma10.0ERBB2, TP53
39malignant mixed mullerian tumor10.0TP53, ERBB2, KRT7
40adenoid cystic carcinoma10.0TP63, ERBB2, KRT7
41li-fraumeni syndrome10.0ERBB2, ESR1
42anaplastic astrocytoma10.0EGFR, TP53
43papilloma10.0KRT5, TP53, TP63
44pancreatic cancer10.0EGFR, KRT7, MUC5AC
45basal cell carcinoma10.0KRT7, TP53, TP63
46esophageal cancer10.0TP53, EGFR
47oral cancer10.0TP53, KRT5, EGFR
48kidney cancer10.0TP53, KRT7, EGFR
49cervical adenocarcinoma10.0ESR1, MUC5AC, KRT7
50oligodendroglioma10.0EGFR, TP53

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to hidradenocarcinoma

Symptoms for Hidradenocarcinoma

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Drugs & Therapeutics for Hidradenocarcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Hidradenocarcinoma

Search NIH Clinical Center for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

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Anatomical Context for Hidradenocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Hidradenocarcinoma:

33
Skin, Breast

Animal Models for Hidradenocarcinoma or affiliated genes

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37MGI
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Publications for Hidradenocarcinoma

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52PubMed
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Articles related to Hidradenocarcinoma:

(show all 40)
idTitleAuthorsYear
1
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. (23489214)
2013
2
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. (22998159)
2013
3
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. (23466792)
2013
4
Hidradenocarcinoma of the Finger. (23486133)
2013
5
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. (23053773)
2013
6
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. (22678002)
2012
7
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. (23271300)
2012
8
No sweat, a rare case of hidradenocarcinoma. (22369809)
2012
9
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. (21892057)
2011
10
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. (21844475)
2011
11
Hidradenocarcinoma of the fingertip: a case report and literature review. (21489038)
2011
12
Radiotherapy on hidradenocarcinoma. (22540063)
2011
13
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. (21044227)
2010
14
Perianal nodular hidradenocarcinoma. Case report. (20478121)
2010
15
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. (20572504)
2010
16
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. (19522717)
2010
17
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. (19476529)
2009
18
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (20596988)
2009
19
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. (19384064)
2009
20
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. (19215270)
2009
21
Metastatic hidradenocarcinoma: Surgery and chemotherapy. (22666726)
2009
22
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. (20740144)
2009
23
Clear cell hidradenocarcinoma developing in pacemaker pocket. (18950311)
2008
24
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. (17214855)
2007
25
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. (17103407)
2007
26
Hidradenocarcinoma: a histological and immunohistochemical study. (17083691)
2006
27
Metastatic hidradenocarcinoma: efficacy of capecitabine. (17043204)
2006
28
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. (15355375)
2004
29
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. (10955691)
2000
30
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
31
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. (8626149)
1996
32
Metastatic clear-cell hidradenocarcinoma of the vulva. (8428700)
1993
33
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. (2984259)
1985
34
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. (6328124)
1984
35
Eccrine hidradenocarcinoma of the vulva with Paget's disease. Case report with a review of the literature. (6295435)
1983
36
Clear cell hidradenocarcinoma. Report of an unusual case. (190056)
1976
37
Hidradenocarcinoma: report of a case. (4310623)
1969
38
Clear cell hidradenoma and hidradenocarcinoma. (14032110)
1963
39
A clear-cell hidradenocarcinoma with metastases. (13472651)
1957
40
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952

Variations for Hidradenocarcinoma

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Expression for genes affiliated with Hidradenocarcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hidradenocarcinoma

Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for genes affiliated with Hidradenocarcinoma

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 60Thomson Reuters, 12EMD Millipore, 61Tocris Bioscience, 51PharmGKB, 54R&D Systems, 57SinoBiological
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Pathways related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6EGFR, ERBB2
29.6EGFR, ERBB2
3
Show member pathways
9.6EGFR, ERBB2
49.6EGFR, ERBB2
59.6ERBB2, EGFR
6
Show member pathways
9.6ERBB2, EGFR
79.6KRT7, KRT5
8
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.5EGFR, ESR1
99.5ESR1, EGFR
10
Show member pathways
9.4TP53, TP63
119.4EGFR, TP53
129.3TP53, ESR1
139.3ESR1, TP53
149.3ESR1, TP53
15
Show member pathways
9.1EGFR, ERBB2, ESR1
16
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.1ERBB2, EGFR, ESR1
17
Show member pathways
9.1ERBB2, ESR1, EGFR
18
Show member pathways
9.0EGFR, ERBB2, TP53
19
Show member pathways
9.0ERBB2, TP53, EGFR
20
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.0TP53, ERBB2, EGFR
219.0EGFR, TP53, ERBB2
229.0ERBB2, EGFR, TP53
23
Show member pathways
Signal transduction PTEN pathway60
9.0TP53, EGFR, ERBB2
24
Show member pathways
9.0TP53, EGFR, ERBB2
259.0ERBB2, TP53, EGFR
26
Show member pathways
Signaling Pathways in Glioblastoma38
9.0ERBB2, EGFR, TP53
27
Show member pathways
9.0ERBB2, EGFR, TP53
289.0TP63, TP53, EGFR
298.9EGFR, TP53, ESR1
308.6ERBB2, TP63, TP53, EGFR
31
Show member pathways
8.5EGFR, ERBB2, ESR1, TP53
32
Show member pathways
8.5EGFR, ERBB2, ESR1, TP53
33
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.5EGFR, TP53, ERBB2, ESR1
348.5ESR1, TP53, ERBB2, EGFR
358.5ERBB2, ESR1, TP53, EGFR

Compounds for genes affiliated with Hidradenocarcinoma

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1topotecan45 1111.4EGFR
2afatinib51 1110.9EGFR, ERBB2
3jnj 28871063 hydrochloride619.9ERBB2, EGFR
4alkylating agents519.9EGFR, ESR1
5ag 490619.9EGFR, ERBB2
6ag 1478 hydrochloride619.9ERBB2, EGFR
7iressa619.8ERBB2, EGFR
8pd158780459.8ERBB2, EGFR
9ag 1478459.8MUC5AC
10fadrozole459.6ERBB2, ESR1
11exemestane45 51 61 1112.5EGFR, ERBB2, ESR1
12anastrozole45 51 1111.5EGFR, ERBB2, ESR1
13everolimus45 51 1111.5EGFR, ERBB2, ESR1
14lapatinib45 51 1111.5ESR1, ERBB2, EGFR
15fulvestrant45 51 29 1112.5EGFR, ESR1, ERBB2
16letrozole45 51 61 1112.5EGFR, ESR1, ERBB2
17trastuzumab45 51 1111.4ERBB2, ESR1, EGFR
184-hydroxytamoxifen459.4ESR1, ERBB2, EGFR
19suberoylanilide hydroxamic acid459.4TP53, EGFR, ERBB2
20oxaliplatin45 51 1111.4ERBB2, TP53, EGFR
21radicicol45 61 1111.4ERBB2, ESR1, TP53
22flavopiridol45 1110.4ERBB2, TP53, EGFR
23n-(4-hydroxyphenyl)retinamide459.3ESR1, ERBB2, TP53
24bortezomib45 51 1111.3TP53, EGFR, ERBB2
25gefitinib45 51 1111.2ESR1, ERBB2, EGFR
26hematoxylin459.0TP63, MUC5AC, KRT7
27irinotecan45 51 1111.0EGFR, TP53, ERBB2
28progestin459.0EGFR, ERBB2, ESR1
29taxane458.9ESR1, ERBB2, EGFR, TP53
30geldanamycin45 51 61 1111.9TP53, ESR1, EGFR, ERBB2
31docetaxel45 51 61 1111.9TP53, ESR1, EGFR, ERBB2
32genistein45 29 61 3 24 1113.9ERBB2, KRT5, ESR1, EGFR
33tamoxifen45 51 29 1111.9ERBB2, ESR1, EGFR, TP53
34paclitaxel45 51 1110.8ESR1, EGFR, TP53, ERBB2
35ly294002458.8ESR1, TP53, EGFR, ERBB2
36carboplatin45 51 1110.7EGFR, ERBB2, TP53
37methotrexate51 45 1110.6KRT7, ERBB2, ESR1, MUC5AC
38n acetylcysteine458.6MUC5AC, ERBB2, EGFR, TP53
39arginine458.6TP63, TP53, ERBB2, KRT7, KRT5
40doxorubicin45 51 1110.5EGFR, ERBB2, TP63, ESR1, TP53
41cisplatin45 51 61 1111.5EGFR, ERBB2, ESR1, TP53, TP63
425fluorouracil458.1TP53, ESR1, MUC5AC, ERBB2, EGFR
43vegf458.0TP63, TP53, ESR1, ERBB2, KRT7, EGFR
44tyrosine457.9MUC5AC, ERBB2, EGFR, KRT5, KRT7, TP63
45retinoid457.6KRT5, MUC5AC, ESR1, EGFR, KRT7, TP53
46testosterone45 61 24 1110.5TP63, ESR1, MUC5AC, ERBB2, KRT7, KRT5
47retinoic acid45 248.2ESR1, MUC5AC, TP63, KRT7, EGFR, TP53
48paraffin456.9EGFR, TP63, TP53, ESR1, MUC5AC, ERBB2
49progesterone45 29 61 24 1110.9ESR1, TP53, TP63, EGFR, ERBB2, KRT7
50estrogen456.8TP63, TP53, ESR1, MUC5AC, EGFR, KRT5

GO Terms for genes affiliated with Hidradenocarcinoma

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16Gene Ontology
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Cellular components related to Hidradenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.4TP53, TP63
2cytoplasmGO:0057377.4EGFR, KRT5, KRT7, ERBB2, TP53, TP63

Biological processes related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell developmentGO:0020649.9ESR1, TP63
2cellular response to estradiol stimulusGO:0713929.8EGFR, ESR1
3mitotic G1 DNA damage checkpointGO:0315719.8TP53, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.8TP63, TP53
5positive regulation of nitric oxide biosynthetic processGO:0454299.7ESR1, EGFR
6response to X-rayGO:0101659.7TP53, TP63
7cell agingGO:0075699.7TP63, TP53
8positive regulation of MAP kinase activityGO:0434069.7ERBB2, EGFR
9response to gamma radiationGO:0103329.7TP53, TP63
10intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.7TP63, TP53
11cellular response to UVGO:0346449.6TP53, TP63
12neuron apoptotic processGO:0514029.6TP53, TP63
13positive regulation of fibroblast proliferationGO:0481469.6EGFR, ESR1
14positive regulation of epithelial cell proliferationGO:0506799.5EGFR, ERBB2
15cellular response to drugGO:0356909.4EGFR, TP53
16chromatin remodelingGO:0063389.2TP63, ESR1
17cell proliferationGO:0082839.2TP53, ERBB2, EGFR
18negative regulation of apoptotic processGO:0430669.0EGFR, TP53, TP63
19positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TP63, TP53, ESR1, EGFR

Molecular functions related to Hidradenocarcinoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.9ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:0047169.8EGFR, ERBB2
3transmembrane receptor protein tyrosine kinase activityGO:0047149.7EGFR, ERBB2
4nitric-oxide synthase regulator activityGO:0302359.7EGFR, ESR1
5damaged DNA bindingGO:0036849.4TP63, TP53
6RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0010779.4TP53, TP63
7protein phosphatase bindingGO:0199039.3EGFR, ERBB2, TP53
8p53 bindingGO:0020399.1TP53, TP63
9enzyme bindingGO:0198999.0EGFR, ESR1, TP53
10protein heterodimerization activityGO:0469828.9EGFR, ERBB2, TP53
11chromatin bindingGO:0036828.7TP63, TP53, ESR1, EGFR
12identical protein bindingGO:0428028.4EGFR, ERBB2, ESR1, TP53, TP63
13protein bindingGO:0055157.4TP63, TP53, ESR1, ERBB2, KRT7, KRT5

Products for genes affiliated with Hidradenocarcinoma

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Sources for Hidradenocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet