MCID: HDR006
MIFTS: 43

Hidradenocarcinoma malady

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Hidradenocarcinoma

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Aliases & Descriptions for Hidradenocarcinoma:

Name: Hidradenocarcinoma 48
Primary Mucoepidermoid Cutaneous Carcinoma 48
Malignant Nodular/clear Cell Hidradenoma 48
Malignant Clear Cell Acrospiroma 48
 
Clear Cell Eccrine Carcinoma 48
Sweat Gland Adenocarcinoma 68
Eccrine Ductal Carcinoma 68
Malignant Acrospiroma 48

Classifications:



Summaries for Hidradenocarcinoma

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NIH Rare Diseases:48 Hidradenocarcinoma is a rare tumor caused by the abnormal growth of cells in a sweat gland.  it is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but can be been found on other parts of the body. this type of tumor most often develops in people between the ages of 30-60 years old, but has been found in children.  hidradenocarcinoma is usually painless and tends to grow slowly, but may spread into nearby tissues, especially lymph nodes, or to more distant parts of the body (metastasis). the cause of the tumor is unknown. diagnosis is usually made by careful examination and a series of special skin tests. the main treatment is surgical removal of the tumor often followed by radiation therapy and/or chemotherapy. long term outlook is best when the cancer is found early. last updated: 8/24/2016

MalaCards based summary: Hidradenocarcinoma, also known as primary mucoepidermoid cutaneous carcinoma, is related to vulvar clear cell hidradenocarcinoma and malignant acrospiroma. An important gene associated with Hidradenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways are Platinum drug resistance and TP53 Network. Affiliated tissues include skin, lymph node and testes, and related mouse phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and craniofacial.

Wikipedia:71 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Related Diseases for Hidradenocarcinoma

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Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1vulvar clear cell hidradenocarcinoma11.9
2malignant acrospiroma10.8
3eccrine porocarcinoma10.8
4breast sarcoma10.3ERBB2, PIP
5male infertility10.3BCL2, CCND1
6skeletal tuberculosis10.3CCND1, ERBB2
7pineal region mature teratoma10.3EGFR, ERBB2
8kidney disease10.3BCL2, NKX2-1, TP53
9adult central nervous system mature teratoma10.3CCND1, ERBB2, TP53
10infiltrating lipoma10.3CCND1, S100B
11bladder clear cell adenocarcinoma10.3ESR1, TP53
12mouth disease10.3ERBB2, PGR
13bone deterioration disease10.3NKX2-1, S100B, TP53
14secondary hyperparathyroidism of renal origin10.2EGFR, PIP, TP53
15acquired hemangioma10.2CDX2, ERBB2, TP53
16exudative glomerulonephritis10.2EGFR, NKX2-1, TP53
17aortitis10.2PGR, TP53
18prostate signet ring cell adenocarcinoma10.2EGFR, ERBB2, MUC2
19lupus - neurological sequelae10.2S100B, VIM
2013q12.3 microdeletion syndrome10.2BCL2, CCND1, VIM
21tabes dorsalis10.2CDX2, MUC2, TP53
22aicardi-goutieres syndrome10.2CDX2, MUC2, TP53
23inverted papilloma10.2ERBB2, NKX2-1, VIM
24radiculopathy10.2KRT7, TP63
25bartholin's gland benign neoplasm10.2ESR1, PGR
26brachial plexus neuropathy10.2EGFR, NKX2-1, TP53
27conjunctival cancer10.2S100B, TP53, VIM
28mucoepidermoid thyroid carcinoma10.2ERBB2, KRT5, PGR
29cardiovascular organ benign neoplasm10.2ESR1, PGR
30breast pericanalicular fibroadenoma10.2NKX2-1, PGR, TP53
31glioma10.2ERBB2, ESR1, PGR
32wolffian adnexal neoplasm10.2EGFR, MKI67, TP53
33appendix leiomyoma10.2ESR1, PGR
34vulva squamous cell carcinoma10.2ERBB2, KRT7, PIP
35angiolipomatosis, familial10.2ERBB2, KRT7, PIP
36histiocytic and dendritic cell cancer10.2ERBB2, ESR1, PGR
37neuroretinitis10.2CCND1, CDX2, MUC2
38her2-receptor negative breast cancer10.2ERBB2, ESR1, PGR
39bronchus adenoma10.2ESR1, PGR
40gallbladder papillomatosis10.2BCL2, PGR, TP53
41ideomotor apraxia10.2CCND1, CDX2, TP53
42lung adenoid cystic carcinoma10.1BCL2, CCND1, MKI67
43spinal cord oligodendroglioma10.1KRT5, MKI67, TP53
44reticulosarcoma10.1PIP, TP53
45connective tissue benign neoplasm10.1CCND1, EGFR, TP53
46childhood brain germinoma10.1S100B, TP53, VIM
47triple-receptor negative breast cancer10.1EGFR, ERBB2, PGR
48skin sarcoma10.1EGFR, ERBB2, PGR
49atypical lipomatous tumor10.1ESR1, PGR, TP63
50ovarian epithelial cancer10.1BCL2, S100B, VIM

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to hidradenocarcinoma

Symptoms & Phenotypes for Hidradenocarcinoma

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GenomeRNAi Phenotypes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00104-A-09.2CCND1, ESR1, MKI67, PIP

MGI Mouse Phenotypes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

41 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.2BCL2, CCND1, EGFR, ERBB2, KRT5, TP53
2MP:00030128.3EGFR, ESR1, KRT5, NKX2-1, PGR, TP53
3MP:00053718.2CDX2, EGFR, ERBB2, ESR1, KRT5, PGR
4MP:00053808.2CDX2, EGFR, ERBB2, ESR1, PGR, TP53
5MP:00053698.1BCL2, EGFR, ERBB2, ESR1, PGR, TP53
6MP:00053888.0BCL2, CCND1, EGFR, ERBB2, ESR1, NKX2-1
7MP:00053908.0CCND1, CDX2, EGFR, ERBB2, ESR1, NKX2-1
8MP:00020067.7BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
9MP:00053787.7BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
10MP:00107717.3BCL2, CCND1, EGFR, ERBB2, ESR1, KRT5
11MP:00028737.3CCND1, CDX2, EGFR, ERBB2, ESR1, MKI67
12MP:00053867.0BCL2, CCND1, ERBB2, ESR1, KRT5, MUC5AC
13MP:00053896.9BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
14MP:00107686.7BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
15MP:00053876.7BCL2, CCND1, EGFR, ESR1, MUC2, MUC5AC
16MP:00053796.5BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
17MP:00053816.3BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
18MP:00053856.3BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
19MP:00053845.6BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1
20MP:00053765.5BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1

Drugs & Therapeutics for Hidradenocarcinoma

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Drugs for Hidradenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
nivolumabapprovedPhase 2424946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
2ImmunoglobulinsPhase 26394
3Antibodies, MonoclonalPhase 24039
4AntibodiesPhase 26394

Interventional clinical trials:

idNameStatusNCT IDPhase
1Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin CancersNot yet recruitingNCT02978625Phase 2

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Genetic Tests for Hidradenocarcinoma

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Anatomical Context for Hidradenocarcinoma

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MalaCards organs/tissues related to Hidradenocarcinoma:

36
Skin, Lymph node, Testes, Breast

Publications for Hidradenocarcinoma

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Articles related to Hidradenocarcinoma:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis. (26876052)
2016
2
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. (26288440)
2015
3
Management of Metastatic Apocrine Hidradenocarcinoma with Chemotherapy and Radiation. (26500736)
2015
4
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. (25627632)
2015
5
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. (25815059)
2015
6
Whole exome sequencing of a patient with metastatic hidradenocarcinoma and review of the literature. (25918615)
2015
7
Case report: clear cell hidradenocarcinoma of the nail bed. (26416223)
2015
8
Hidradenocarcinoma of the finger: a rare tumor, mimicking a giant cell tumor of the tendon sheath. (26319286)
2015
9
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. (25006935)
2014
10
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. (24490986)
2014
11
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. (25513929)
2014
12
Hidradenocarcinoma of the chest. (25382529)
2014
13
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. (23489214)
2013
14
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. (23466792)
2013
15
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. (23053773)
2013
16
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. (22998159)
2013
17
Hidradenocarcinoma of the Finger. (23486133)
2013
18
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. (23271300)
2012
19
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. (22678002)
2012
20
No sweat, a rare case of hidradenocarcinoma. (22369809)
2012
21
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. (21892057)
2011
22
Radiotherapy on hidradenocarcinoma. (22540063)
2011
23
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. (21844475)
2011
24
Hidradenocarcinoma of the fingertip: a case report and literature review. (21489038)
2011
25
Perianal nodular hidradenocarcinoma. Case report. (20478121)
2010
26
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. (21044227)
2010
27
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. (20572504)
2010
28
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. (19522717)
2010
29
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (20596988)
2009
30
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. (20740144)
2009
31
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. (19215270)
2009
32
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. (19476529)
2009
33
Metastatic hidradenocarcinoma: Surgery and chemotherapy. (22666726)
2009
34
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. (19384064)
2009
35
Clear cell hidradenocarcinoma developing in pacemaker pocket. (18950311)
2008
36
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. (17103407)
2007
37
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. (17214855)
2007
38
Hidradenocarcinoma: a histological and immunohistochemical study. (17083691)
2006
39
Metastatic hidradenocarcinoma: efficacy of capecitabine. (17043204)
2006
40
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. (15355375)
2004
41
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. (10955691)
2000
42
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
43
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. (8626149)
1996
44
Metastatic clear-cell hidradenocarcinoma of the vulva. (8428700)
1993
45
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. (2984259)
1985
46
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. (6328124)
1984
47
Eccrine hidradenocarcinoma of the vulva with Paget's disease. Case report with a review of the literature. (6295435)
1983
48
Clear cell hidradenocarcinoma. Report of an unusual case. (190056)
1976
49
Hidradenocarcinoma: report of a case. (4310623)
1969
50
Clear cell hidradenoma and hidradenocarcinoma. (14032110)
1963

Variations for Hidradenocarcinoma

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Cosmic variations for Hidradenocarcinoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM14452PTCH1skin,neck,carcinoma,NSc.2321G>Ap.G774E6
2COSM29072PTCH1skin,neck,carcinoma,NSc.1067+1G>Ap.?6
3COSM29053PTCH1skin,neck,carcinoma,NSc.833G>Ap.W278*6
4COSM498HRASskin,neck,carcinoma,NSc.182A>Tp.Q61L6
5COSM516KRASskin,neck,carcinoma,NSc.34G>Tp.G12C6
6COSM17483PTCH1skin,neck,carcinoma,NSc.1729-1G>Tp.?6
7COSM17468PTCH1skin,neck,carcinoma,NSc.584G>Tp.R195M6

Expression for genes affiliated with Hidradenocarcinoma

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Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for genes affiliated with Hidradenocarcinoma

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Pathways related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathwaysScoreTop Affiliating Genes
19.8BCL2, ERBB2, TP53
2
Show member pathways
9.8BCL2, TP53, TP63
39.8BCL2, CCND1, ERBB2
49.8BCL2, CCND1, TP53
59.7EGFR, ERBB2, TP53
6
Show member pathways
9.6EGFR, ERBB2, ESR1
79.5BCL2, CCND1, ERBB2, TP53
8
Show member pathways
9.5CCND1, EGFR, ESR1
99.5CCND1, EGFR, ESR1
10
Show member pathways
9.5BCL2, EGFR, ERBB2, TP53
119.5BCL2, EGFR, TP53, TP63
12
Show member pathways
9.4CCND1, EGFR, ERBB2, TP53
13
Show member pathways
9.4CCND1, EGFR, ERBB2, TP53
14
Show member pathways
9.4CCND1, EGFR, ERBB2, TP53
15
Show member pathways
9.4CCND1, EGFR, ERBB2, TP53
169.4BCL2, CCND1, EGFR, TP53
17
Show member pathways
9.3CCND1, EGFR, ERBB2, ESR1
189.3BCL2, CCND1, TP53, VIM
19
Show member pathways
9.2BCL2, CCND1, EGFR, ERBB2, TP53
209.2BCL2, CCND1, EGFR, ERBB2, TP53
219.2CCND1, EGFR, TP53, VIM
229.1CCND1, EGFR, ERBB2, ESR1, TP53
239.1BCL2, CCND1, EGFR, ESR1, TP53
248.9CCND1, MKI67, TP53, TP63, VIM
25
Show member pathways
8.8EGFR, ERBB2, ESR1, PGR, S100B
268.5BCL2, CCND1, EGFR, ERBB2, TP53, TP63
27
Show member pathways
8.4BCL2, CCND1, EGFR, ERBB2, ESR1, PGR

GO Terms for genes affiliated with Hidradenocarcinoma

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Cellular components related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432349.1BCL2, CDX2, ESR1, TP53, TP63
2cytoplasmGO:00057376.2BCL2, CCND1, EGFR, ERBB2, ESR1, KRT5
3nucleusGO:00056345.8BCL2, CCND1, CDX2, EGFR, ERBB2, ESR1

Biological processes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1Leydig cell differentiationGO:003332710.7CCND1, NKX2-1
2regulation of mitochondrial membrane permeabilityGO:004690210.7BCL2, TP53
3epithelial cell developmentGO:000206410.7ESR1, TP63
4cerebral cortex cell migrationGO:002179510.6EGFR, NKX2-1
5cell agingGO:000756910.6BCL2, TP53, TP63
6positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:190074010.5BCL2, TP53, TP63
7mitotic G1 DNA damage checkpointGO:003157110.5CCND1, TP53, TP63
8positive regulation of cell growthGO:003030710.5BCL2, EGFR, ERBB2
9pattern specification processGO:000738910.4CDX2, NKX2-1, TP63
10response to gamma radiationGO:001033210.3BCL2, TP53, TP63
11response to UV-AGO:007014110.2CCND1, EGFR
12animal organ morphogenesisGO:000988710.2BCL2, CDX2, NKX2-1, TP63
13regulation of apoptotic processGO:004298110.2BCL2, ESR1, TP53, TP63
14response to glucocorticoidGO:005138410.1BCL2, CCND1, S100B
15phosphatidylinositol-mediated signalingGO:00480159.9EGFR, ERBB2, MUC5AC, TP53
16positive regulation of cell proliferationGO:00082849.8BCL2, CCND1, CDX2, EGFR, S100B
17response to X-rayGO:00101659.7CCND1, TP53, TP63
18cell proliferationGO:00082839.6BCL2, EGFR, ERBB2, MKI67, S100B, TP53
19negative regulation of transcription from RNA polymerase II promoterGO:00001229.5CCND1, CDX2, ESR1, NKX2-1, TP53, TP63
20regulation of transcription from RNA polymerase II promoterGO:00063579.5CDX2, EGFR, ERBB2, ESR1, NKX2-1
21positive regulation of gene expressionGO:00106289.4ERBB2, NKX2-1, PIP, TP53, VIM
22positive regulation of transcription, DNA-templatedGO:00458939.4CDX2, EGFR, ESR1, NKX2-1, TP53, TP63

Molecular functions related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase regulator activityGO:003023510.6EGFR, ESR1
2protein phosphatase bindingGO:001990310.2BCL2, EGFR, ERBB2, TP53
3signal transducer, downstream of receptor, with protein tyrosine kinase activityGO:00047169.9EGFR, ERBB2
4glycoprotein bindingGO:00019489.9EGFR, PIP, VIM
5enzyme bindingGO:00198999.3CCND1, EGFR, ESR1, NKX2-1, PGR, TP53
6identical protein bindingGO:00428029.1BCL2, EGFR, ERBB2, ESR1, S100B, TP53
7sequence-specific DNA bindingGO:00435658.8BCL2, CDX2, ESR1, NKX2-1, PGR, TP63
8protein bindingGO:00055155.4BCL2, CCND1, EGFR, ERBB2, ESR1, KRT5

Sources for Hidradenocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet