MCID: HDR006
MIFTS: 43

Hidradenocarcinoma malady

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Hidradenocarcinoma

Aliases & Descriptions for Hidradenocarcinoma:

Name: Hidradenocarcinoma 50
Primary Mucoepidermoid Cutaneous Carcinoma 50
Malignant Nodular/clear Cell Hidradenoma 50
Malignant Clear Cell Acrospiroma 50
Clear Cell Eccrine Carcinoma 50
Sweat Gland Adenocarcinoma 69
Eccrine Ductal Carcinoma 69
Malignant Acrospiroma 50

Classifications:



Summaries for Hidradenocarcinoma

NIH Rare Diseases : 50 hidradenocarcinoma is a rare tumor caused by the abnormal growth of cells in a sweat gland.  it is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but can be been found on other parts of the body. this type of tumor most often develops in people between the ages of 30-60 years old, but has been found in children.  hidradenocarcinoma is usually painless and tends to grow slowly, but may spread into nearby tissues, especially lymph nodes, or to more distant parts of the body (metastasis). the cause of the tumor is unknown. diagnosis is usually made by careful examination and a series of special skin tests. the main treatment is surgical removal of the tumor often followed by radiation therapy and/or chemotherapy. long term outlook is best when the cancer is found early. last updated: 8/24/2016

MalaCards based summary : Hidradenocarcinoma, also known as primary mucoepidermoid cutaneous carcinoma, is related to vulvar clear cell hidradenocarcinoma and malignant acrospiroma. An important gene associated with Hidradenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Glioma and Pathways in cancer. The drugs nivolumab and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and cellular

Wikipedia : 71 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Related Diseases for Hidradenocarcinoma

Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
id Related Disease Score Top Affiliating Genes
1 vulvar clear cell hidradenocarcinoma 11.9
2 malignant acrospiroma 10.8
3 eccrine porocarcinoma 10.8
4 breast sarcoma 10.3 ERBB2 PIP
5 male infertility 10.3 BCL2 CCND1
6 skeletal tuberculosis 10.3 CCND1 ERBB2
7 pineal region mature teratoma 10.3 EGFR ERBB2
8 kidney disease 10.3 BCL2 NKX2-1 TP53
9 adult central nervous system mature teratoma 10.3 CCND1 ERBB2 TP53
10 infiltrating lipoma 10.3 CCND1 S100B
11 bladder clear cell adenocarcinoma 10.3 ESR1 TP53
12 mouth disease 10.3 ERBB2 PGR
13 bone deterioration disease 10.3 NKX2-1 S100B TP53
14 secondary hyperparathyroidism of renal origin 10.2 EGFR PIP TP53
15 acquired hemangioma 10.2 CDX2 ERBB2 TP53
16 exudative glomerulonephritis 10.2 EGFR NKX2-1 TP53
17 aortitis 10.2 PGR TP53
18 prostate signet ring cell adenocarcinoma 10.2 EGFR ERBB2 MUC2
19 lupus - neurological sequelae 10.2 S100B VIM
20 13q12.3 microdeletion syndrome 10.2 BCL2 CCND1 VIM
21 tabes dorsalis 10.2 CDX2 MUC2 TP53
22 aicardi-goutieres syndrome 10.2 CDX2 MUC2 TP53
23 inverted papilloma 10.2 ERBB2 NKX2-1 VIM
24 radiculopathy 10.2 KRT7 TP63
25 bartholin's gland benign neoplasm 10.2 ESR1 PGR
26 brachial plexus neuropathy 10.2 EGFR NKX2-1 TP53
27 conjunctival cancer 10.2 S100B TP53 VIM
28 mucoepidermoid thyroid carcinoma 10.2 ERBB2 KRT5 PGR
29 cardiovascular organ benign neoplasm 10.2 ESR1 PGR
30 breast pericanalicular fibroadenoma 10.2 NKX2-1 PGR TP53
31 glioma 10.2 ERBB2 ESR1 PGR
32 wolffian adnexal neoplasm 10.2 EGFR MKI67 TP53
33 appendix leiomyoma 10.2 ESR1 PGR
34 vulva squamous cell carcinoma 10.2 ERBB2 KRT7 PIP
35 angiolipomatosis, familial 10.2 ERBB2 KRT7 PIP
36 histiocytic and dendritic cell cancer 10.2 ERBB2 ESR1 PGR
37 neuroretinitis 10.2 CCND1 CDX2 MUC2
38 her2-receptor negative breast cancer 10.2 ERBB2 ESR1 PGR
39 bronchus adenoma 10.2 ESR1 PGR
40 gallbladder papillomatosis 10.2 BCL2 PGR TP53
41 ideomotor apraxia 10.2 CCND1 CDX2 TP53
42 lung adenoid cystic carcinoma 10.1 BCL2 CCND1 MKI67
43 spinal cord oligodendroglioma 10.1 KRT5 MKI67 TP53
44 reticulosarcoma 10.1 PIP TP53
45 connective tissue benign neoplasm 10.1 CCND1 EGFR TP53
46 childhood brain germinoma 10.1 S100B TP53 VIM
47 triple-receptor negative breast cancer 10.1 EGFR ERBB2 PGR
48 skin sarcoma 10.1 EGFR ERBB2 PGR
49 atypical lipomatous tumor 10.1 ESR1 PGR TP63
50 ovarian epithelial cancer 10.1 BCL2 S100B VIM

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to Hidradenocarcinoma

Symptoms & Phenotypes for Hidradenocarcinoma

GenomeRNAi Phenotypes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 CCND1 ESR1 MKI67 PIP

MGI Mouse Phenotypes related to Hidradenocarcinoma:

44 (show all 20)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.42 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
2 cardiovascular system MP:0005385 10.4 TP63 VIM BCL2 CCND1 CDX2 EGFR
3 homeostasis/metabolism MP:0005376 10.39 ERBB2 ESR1 KRT7 MUC2 MUC5AC NKX2-1
4 behavior/neurological MP:0005386 10.37 S100B TP53 TP63 VIM BCL2 CCND1
5 digestive/alimentary MP:0005381 10.37 KRT5 MUC2 MUC5AC NKX2-1 PIP TP53
6 endocrine/exocrine gland MP:0005379 10.31 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
7 growth/size/body region MP:0005378 10.26 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
8 mortality/aging MP:0010768 10.25 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
9 immune system MP:0005387 10.24 BCL2 CCND1 EGFR ESR1 MUC2 MUC5AC
10 integument MP:0010771 10.18 S100B TP53 TP63 BCL2 CCND1 EGFR
11 embryo MP:0005380 10.15 CDX2 EGFR ERBB2 ESR1 PGR TP53
12 craniofacial MP:0005382 10.11 TP53 TP63 BCL2 CCND1 EGFR ERBB2
13 neoplasm MP:0002006 10.11 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
14 limbs/digits/tail MP:0005371 10.06 CDX2 EGFR ERBB2 ESR1 KRT5 PGR
15 muscle MP:0005369 10.01 PGR TP53 TP63 VIM EGFR ERBB2
16 normal MP:0002873 10 CCND1 CDX2 EGFR ERBB2 ESR1 MKI67
17 reproductive system MP:0005389 9.93 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
18 no phenotypic analysis MP:0003012 9.87 EGFR ESR1 KRT5 NKX2-1 PGR TP53
19 respiratory system MP:0005388 9.61 BCL2 CCND1 EGFR ERBB2 ESR1 NKX2-1
20 skeleton MP:0005390 9.28 CCND1 CDX2 EGFR ERBB2 ESR1 NKX2-1

Drugs & Therapeutics for Hidradenocarcinoma

Drugs for Hidradenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Immunoglobulins Phase 2
3 Antibodies, Monoclonal Phase 2
4 Antibodies Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Not yet recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

Anatomical Context for Hidradenocarcinoma

MalaCards organs/tissues related to Hidradenocarcinoma:

39
Skin, Lymph Node, Testes, Breast

Publications for Hidradenocarcinoma

Articles related to Hidradenocarcinoma:

(show top 50) (show all 52)
id Title Authors Year
1
Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis. ( 26876052 )
2016
2
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. ( 26288440 )
2015
3
Management of Metastatic Apocrine Hidradenocarcinoma with Chemotherapy and Radiation. ( 26500736 )
2015
4
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. ( 25627632 )
2015
5
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. ( 25815059 )
2015
6
Whole exome sequencing of a patient with metastatic hidradenocarcinoma and review of the literature. ( 25918615 )
2015
7
Case report: clear cell hidradenocarcinoma of the nail bed. ( 26416223 )
2015
8
Hidradenocarcinoma of the finger: a rare tumor, mimicking a giant cell tumor of the tendon sheath. ( 26319286 )
2015
9
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. ( 25006935 )
2014
10
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. ( 24490986 )
2014
11
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. ( 25513929 )
2014
12
Hidradenocarcinoma of the chest. ( 25382529 )
2014
13
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. ( 23489214 )
2013
14
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. ( 23466792 )
2013
15
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. ( 23053773 )
2013
16
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. ( 22998159 )
2013
17
Hidradenocarcinoma of the Finger. ( 23486133 )
2013
18
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. ( 23271300 )
2012
19
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. ( 22678002 )
2012
20
No sweat, a rare case of hidradenocarcinoma. ( 22369809 )
2012
21
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. ( 21892057 )
2011
22
Radiotherapy on hidradenocarcinoma. ( 22540063 )
2011
23
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. ( 21844475 )
2011
24
Hidradenocarcinoma of the fingertip: a case report and literature review. ( 21489038 )
2011
25
Perianal nodular hidradenocarcinoma. Case report. ( 20478121 )
2010
26
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. ( 21044227 )
2010
27
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. ( 20572504 )
2010
28
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. ( 19522717 )
2010
29
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. ( 20596988 )
2009
30
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. ( 20740144 )
2009
31
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. ( 19215270 )
2009
32
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. ( 19476529 )
2009
33
Metastatic hidradenocarcinoma: Surgery and chemotherapy. ( 22666726 )
2009
34
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. ( 19384064 )
2009
35
Clear cell hidradenocarcinoma developing in pacemaker pocket. ( 18950311 )
2008
36
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. ( 17103407 )
2007
37
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. ( 17214855 )
2007
38
Hidradenocarcinoma: a histological and immunohistochemical study. ( 17083691 )
2006
39
Metastatic hidradenocarcinoma: efficacy of capecitabine. ( 17043204 )
2006
40
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. ( 15355375 )
2004
41
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. ( 10955691 )
2000
42
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. ( 9788267 )
1998
43
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. ( 8626149 )
1996
44
Metastatic clear-cell hidradenocarcinoma of the vulva. ( 8428700 )
1993
45
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. ( 2984259 )
1985
46
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. ( 6328124 )
1984
47
Eccrine hidradenocarcinoma of the vulva with Paget's disease. Case report with a review of the literature. ( 6295435 )
1983
48
Clear cell hidradenocarcinoma. Report of an unusual case. ( 190056 )
1976
49
Hidradenocarcinoma: report of a case. ( 4310623 )
1969
50
Clear cell hidradenoma and hidradenocarcinoma. ( 14032110 )
1963

Variations for Hidradenocarcinoma

Cosmic variations for Hidradenocarcinoma:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM14452 PTCH1 skin,neck,carcinoma,NS c.2321G>A p.G774E 6
2 COSM29072 PTCH1 skin,neck,carcinoma,NS c.1067+1G>A p.? 6
3 COSM29053 PTCH1 skin,neck,carcinoma,NS c.833G>A p.W278* 6
4 COSM17483 PTCH1 skin,neck,carcinoma,NS c.1729-1G>T p.? 6
5 COSM17468 PTCH1 skin,neck,carcinoma,NS c.584G>T p.R195M 6
6 COSM516 KRAS skin,neck,carcinoma,NS c.34G>T p.G12C 6
7 COSM498 HRAS skin,neck,carcinoma,NS c.182A>T p.Q61L 6

Expression for Hidradenocarcinoma

Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for Hidradenocarcinoma

Pathways related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 BCL2 CCND1 EGFR ERBB2 ESR1 PGR
2 12.56 BCL2 CCND1 EGFR ERBB2 TP53
3 12.39 CCND1 MKI67 TP53 TP63 VIM
4
Show member pathways
12.35 BCL2 EGFR ERBB2 TP53
5
Show member pathways
12.23 CCND1 EGFR ERBB2 ESR1
6
Show member pathways
12.21 CCND1 EGFR ERBB2 TP53
7
Show member pathways
12.18 BCL2 CCND1 EGFR ERBB2 TP53
8
Show member pathways
12.07 CCND1 EGFR ERBB2 TP53
9 12.07 CCND1 EGFR ERBB2 ESR1 TP53
10
Show member pathways
11.99 CCND1 EGFR ERBB2 TP53
11 11.96 BCL2 EGFR TP53 TP63
12 11.89 CCND1 EGFR TP53 VIM
13 11.86 BCL2 CCND1 ERBB2 TP53
14 11.84 BCL2 CCND1 TP53 VIM
15 11.84 BCL2 CCND1 EGFR ESR1 TP53
16
Show member pathways
11.78 EGFR ERBB2 ESR1
17 11.72 BCL2 CCND1 TP53
18 11.66 BCL2 ERBB2 TP53
19 11.64 BCL2 CCND1 EGFR ERBB2 TP53 TP63
20
Show member pathways
11.63 CCND1 EGFR ESR1
21 11.59 CCND1 EGFR ESR1
22 11.57 EGFR ERBB2 TP53
23 11.54 BCL2 CCND1 ERBB2
24 11.49 CCND1 EGFR ERBB2 TP53
25
Show member pathways
11.39 EGFR ERBB2 ESR1 PGR S100B
26 11.16 BCL2 CCND1 EGFR TP53
27
Show member pathways
10.98 BCL2 TP53 TP63

GO Terms for Hidradenocarcinoma

Cellular components related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.8 BCL2 CCND1 EGFR ERBB2 ESR1 KRT5
2 protein complex GO:0043234 9.55 BCL2 CDX2 ESR1 TP53 TP63
3 nucleus GO:0005634 9.5 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1

Biological processes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.96 BCL2 CCND1 CDX2 EGFR S100B
2 positive regulation of transcription, DNA-templated GO:0045893 9.95 CDX2 EGFR ESR1 NKX2-1 TP53 TP63
3 positive regulation of gene expression GO:0010628 9.89 ERBB2 NKX2-1 PIP TP53 VIM
4 regulation of apoptotic process GO:0042981 9.85 BCL2 ESR1 TP53 TP63
5 positive regulation of cell growth GO:0030307 9.76 BCL2 EGFR ERBB2
6 response to glucocorticoid GO:0051384 9.71 BCL2 CCND1 S100B
7 animal organ morphogenesis GO:0009887 9.71 BCL2 CDX2 NKX2-1 TP63
8 pattern specification process GO:0007389 9.69 CDX2 NKX2-1 TP63
9 response to gamma radiation GO:0010332 9.61 BCL2 TP53 TP63
10 cerebral cortex cell migration GO:0021795 9.6 EGFR NKX2-1
11 regulation of mitochondrial membrane permeability GO:0046902 9.59 BCL2 TP53
12 epithelial cell development GO:0002064 9.58 ESR1 TP63
13 Leydig cell differentiation GO:0033327 9.57 CCND1 NKX2-1
14 phosphatidylinositol-mediated signaling GO:0048015 9.56 EGFR ERBB2 MUC5AC TP53
15 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.54 BCL2 TP53 TP63
16 cell aging GO:0007569 9.5 BCL2 TP53 TP63
17 response to UV-A GO:0070141 9.46 CCND1 EGFR
18 cell proliferation GO:0008283 9.43 BCL2 EGFR ERBB2 MKI67 S100B TP53
19 response to X-ray GO:0010165 9.33 CCND1 TP53 TP63
20 mitotic G1 DNA damage checkpoint GO:0031571 8.8 CCND1 TP53 TP63
21 regulation of transcription from RNA polymerase II promoter GO:0006357 10 CDX2 EGFR ERBB2 ESR1 NKX2-1
22 negative regulation of transcription from RNA polymerase II promoter GO:0000122 10 CCND1 CDX2 ESR1 NKX2-1 TP53 TP63

Molecular functions related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.73 BCL2 CDX2 ESR1 NKX2-1 PGR TP63
2 glycoprotein binding GO:0001948 9.54 EGFR PIP VIM
3 protein phosphatase binding GO:0019903 9.46 BCL2 EGFR ERBB2 TP53
4 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.43 EGFR ERBB2
5 enzyme binding GO:0019899 9.43 CCND1 EGFR ESR1 NKX2-1 PGR TP53
6 nitric-oxide synthase regulator activity GO:0030235 9.32 EGFR ESR1
7 identical protein binding GO:0042802 9.23 BCL2 EGFR ERBB2 ESR1 S100B TP53
8 protein binding GO:0005515 10.31 BCL2 CCND1 EGFR ERBB2 ESR1 KRT5

Sources for Hidradenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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