MCID: HDR006
MIFTS: 47

Hidradenocarcinoma

Categories: Rare diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Hidradenocarcinoma

MalaCards integrated aliases for Hidradenocarcinoma:

Name: Hidradenocarcinoma 49
Primary Mucoepidermoid Cutaneous Carcinoma 49
Malignant Nodular/clear Cell Hidradenoma 49
Malignant Clear Cell Acrospiroma 49
Clear Cell Eccrine Carcinoma 49
Sweat Gland Adenocarcinoma 69
Eccrine Ductal Carcinoma 69
Malignant Acrospiroma 49

Classifications:



External Ids:

UMLS 69 C0334344

Summaries for Hidradenocarcinoma

NIH Rare Diseases : 49 Hidradenocarcinoma is a rare tumor caused by the abnormal growth of cells in a sweat gland.  It is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but can be been found on other parts of the body. This type of tumor most often develops in people between the ages of 30-60 years old, but has been found in children.  Hidradenocarcinoma is usually painless and tends to grow slowly, but may spread into nearby tissues, especially lymph nodes, or to more distant parts of the body (metastasis). The cause of the tumor is unknown. Diagnosis is usually made by careful examination and a series of special skin tests. The main treatment is surgical removal of the tumor often followed by radiation therapy and/or chemotherapy. Long term outlook is best when the cancer is found early. Last updated: 8/24/2016

MalaCards based summary : Hidradenocarcinoma, also known as primary mucoepidermoid cutaneous carcinoma, is related to nodular hidradenoma and malignant acrospiroma. An important gene associated with Hidradenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Pathways in cancer and DNA Damage. The drugs nivolumab and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and cellular

Wikipedia : 72 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Related Diseases for Hidradenocarcinoma

Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 nodular hidradenoma 30.0 KRT7 PIP VIM
2 malignant acrospiroma 12.2
3 vulvar clear cell hidradenocarcinoma 12.0
4 breast neuroendocrine neoplasm 10.6 ERBB2 PIP
5 bartholin's duct cyst 10.6 PIP TP53
6 uterine corpus serous adenocarcinoma 10.5 ERBB2 TP53
7 cystic basal cell carcinoma 10.5 KRT7 TP63
8 glioma susceptibility 1 10.5 ERBB2 TP53
9 breast cystic hypersecretory carcinoma 10.5 ERBB2 KRT5
10 glassy cell carcinoma of the cervix 10.5 ERBB2 ESR1
11 spitz nevus 10.5 MKI67 TP53
12 cutaneous adenocystic carcinoma 10.5 KRT7 PIP
13 breast intraductal proliferative lesion 10.5 EGFR ERBB2
14 lung acinar adenocarcinoma 10.5 KRT7 NKX2-1
15 vestibular gland benign neoplasm 10.5 ESR1 TP53
16 endometrial clear cell adenocarcinoma 10.5 ESR1 TP53
17 bartholin's gland adenoma 10.5 ESR1 TP53
18 hemangioma of lung 10.4 NKX2-1 TP63
19 oral leukoplakia 10.4 ERBB2 MKI67 TP53
20 large intestine adenocarcinoma 10.4 KRT7 PIP
21 ovarian germ cell teratoma 10.4 KRT7 NKX2-1
22 vulval paget's disease 10.4 ERBB2 KRT7 PIP
23 vulvar intraepithelial neoplasia 10.4 KRT7 TP53
24 breast medullary carcinoma 10.4 ERBB2 ESR1
25 comedo carcinoma 10.4 ERBB2 ESR1
26 malignant giant cell tumor 10.4 S100B TP53
27 paget disease, extramammary 10.4 ERBB2 KRT7 PIP
28 intracystic papillary adenoma 10.4 EGFR ERBB2
29 progesterone-receptor negative breast cancer 10.4 EGFR ERBB2
30 inverted transitional papilloma 10.4 KRT5 KRT7
31 papillary thyroid microcarcinoma 10.4 MKI67 NKX2-1 TP63
32 balloon cell malignant melanoma 10.4 KRT5 KRT7
33 small cell carcinoma of the bladder 10.4 KRT7 NKX2-1
34 ovarian germ cell cancer 10.4 KRT7 NKX2-1
35 female reproductive endometrioid cancer 10.4 KRT7 TP53
36 chordoid glioma 10.4 NKX2-1 S100B TP53
37 sensory organ benign neoplasm 10.4 KRT5 KRT7
38 malignant ovarian surface epithelial-stromal neoplasm 10.4 ERBB2 KRT7 TP53
39 ovary epithelial cancer 10.4 ERBB2 KRT7 TP53
40 middle ear adenoma 10.4 KRT5 KRT7
41 papillary serous adenocarcinoma 10.4 KRT7 NKX2-1 TP53
42 integumentary system cancer 10.4 KRT7 PIP TP53
43 keratinizing squamous cell carcinoma 10.4 KRT5 TP53
44 uterine corpus cancer 10.3 ERBB2 ESR1 TP53
45 cervical carcinosarcoma 10.3 BCL2 ESR1 TP53
46 breast papillomatosis 10.3 CCND1 ERBB2
47 lymphoma, small cleaved-cell, diffuse 10.3 BCL2 CCND1
48 inverted papilloma 10.3 KRT7 MKI67 TP53
49 fallopian tube carcinoma 10.3 ERBB2 ESR1 TP53
50 papillary carcinoma 10.3 ERBB2 KRT7 NKX2-1

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to Hidradenocarcinoma

Symptoms & Phenotypes for Hidradenocarcinoma

GenomeRNAi Phenotypes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 CCND1 ESR1 MKI67 PIP

MGI Mouse Phenotypes related to Hidradenocarcinoma:

43 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.38 PIP TP63 TP53 NKX2-1 EGFR CCND1
2 digestive/alimentary MP:0005381 10.36 PIP TP63 TP53 MUC5AC NKX2-1 CCND1
3 cardiovascular system MP:0005385 10.35 PIP TP63 TP53 NKX2-1 EGFR CCND1
4 homeostasis/metabolism MP:0005376 10.34 NKX2-1 S100B MUC2 MUC5AC TP53 EGFR
5 behavior/neurological MP:0005386 10.32 TP53 NKX2-1 S100B MUC5AC CCND1 BCL2
6 endocrine/exocrine gland MP:0005379 10.26 NKX2-1 PIP TP63 TP53 EGFR CCND1
7 growth/size/body region MP:0005378 10.25 TP53 NKX2-1 MUC2 CCND1 BCL2 CDX2
8 immune system MP:0005387 10.18 TP53 PIP MUC2 MUC5AC CCND1 BCL2
9 mortality/aging MP:0010768 10.18 TP53 NKX2-1 MUC2 EGFR CCND1 BCL2
10 embryo MP:0005380 10.14 TP53 EGFR BCL2 CDX2 VIM TP63
11 integument MP:0010771 10.11 S100B TP53 EGFR CCND1 BCL2 TP63
12 craniofacial MP:0005382 10.1 TP53 EGFR CCND1 BCL2 TP63 ERBB2
13 neoplasm MP:0002006 10.02 TP63 TP53 NKX2-1 CCND1 BCL2 CDX2
14 limbs/digits/tail MP:0005371 9.98 TP53 EGFR CDX2 TP63 ESR1 KRT5
15 muscle MP:0005369 9.91 TP53 BCL2 TP63 VIM ERBB2 EGFR
16 normal MP:0002873 9.85 NKX2-1 S100B TP53 EGFR CCND1 CDX2
17 no phenotypic analysis MP:0003012 9.8 TP53 NKX2-1 TP63 KRT5 MKI67 EGFR
18 reproductive system MP:0005389 9.7 NKX2-1 PIP TP63 TP53 EGFR CCND1
19 respiratory system MP:0005388 9.23 TP53 NKX2-1 EGFR CCND1 VIM TP63

Drugs & Therapeutics for Hidradenocarcinoma

Drugs for Hidradenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies, Monoclonal Phase 2
3 Immunoglobulins Phase 2
4 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

Anatomical Context for Hidradenocarcinoma

MalaCards organs/tissues related to Hidradenocarcinoma:

38
Skin, Lymph Node, Testes, Breast

Publications for Hidradenocarcinoma

Articles related to Hidradenocarcinoma:

(show top 50) (show all 58)
# Title Authors Year
1
18F-FDG PET/CT Imaging of Hidradenocarcinoma Arising From Preexisting Hidradenoma of the Knee. ( 29166328 )
2018
2
Hidradenocarcinoma of the Dorsum of the Hand. ( 28685735 )
2017
3
Complete response in a patient with gynecological hidradenocarcinoma treated with exclusive external beam radiotherapy and brachytherapy: a case report. ( 29441103 )
2017
4
Perianal eccrine hidradenocarcinoma in the context of a fistulising Crohn's disease. ( 28827020 )
2017
5
Translocation of the MAML2 gene in hidradenocarcinoma. ( 28295544 )
2017
6
Fatal hidradenocarcinoma of the scalp: A case report. ( 28410954 )
2017
7
Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis. ( 26876052 )
2016
8
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. ( 25627632 )
2015
9
Whole exome sequencing of a patient with metastatic hidradenocarcinoma and review of the literature. ( 25918615 )
2015
10
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. ( 25815059 )
2015
11
Hidradenocarcinoma of the finger: a rare tumor, mimicking a giant cell tumor of the tendon sheath. ( 26319286 )
2015
12
Management of Metastatic Apocrine Hidradenocarcinoma with Chemotherapy and Radiation. ( 26500736 )
2015
13
Case report: clear cell hidradenocarcinoma of the nail bed. ( 26416223 )
2015
14
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. ( 26288440 )
2015
15
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. ( 24490986 )
2014
16
Hidradenocarcinoma of the chest. ( 25382529 )
2014
17
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. ( 25513929 )
2014
18
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. ( 25006935 )
2014
19
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. ( 23489214 )
2013
20
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. ( 23053773 )
2013
21
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. ( 23466792 )
2013
22
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. ( 22998159 )
2013
23
Hidradenocarcinoma of the Finger. ( 23486133 )
2013
24
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. ( 22678002 )
2012
25
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. ( 23271300 )
2012
26
No sweat, a rare case of hidradenocarcinoma. ( 22369809 )
2012
27
Hidradenocarcinoma of the fingertip: a case report and literature review. ( 21489038 )
2011
28
Radiotherapy on hidradenocarcinoma. ( 22540063 )
2011
29
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. ( 21844475 )
2011
30
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. ( 21892057 )
2011
31
Perianal nodular hidradenocarcinoma. Case report. ( 20478121 )
2010
32
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. ( 19522717 )
2010
33
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. ( 21044227 )
2010
34
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. ( 20572504 )
2010
35
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. ( 20596988 )
2009
36
Metastatic hidradenocarcinoma: Surgery and chemotherapy. ( 22666726 )
2009
37
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. ( 19476529 )
2009
38
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. ( 19215270 )
2009
39
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. ( 20740144 )
2009
40
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. ( 19384064 )
2009
41
Clear cell hidradenocarcinoma developing in pacemaker pocket. ( 18950311 )
2008
42
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. ( 17103407 )
2007
43
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. ( 17214855 )
2007
44
Metastatic hidradenocarcinoma: efficacy of capecitabine. ( 17043204 )
2006
45
Hidradenocarcinoma: a histological and immunohistochemical study. ( 17083691 )
2006
46
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. ( 15355375 )
2004
47
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. ( 10955691 )
2000
48
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. ( 9788267 )
1998
49
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. ( 8626149 )
1996
50
Metastatic clear-cell hidradenocarcinoma of the vulva. ( 8428700 )
1993

Variations for Hidradenocarcinoma

Cosmic variations for Hidradenocarcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM17483 PTCH1 skin,neck,carcinoma,NS c.1729-1G>T p.? 6
2 COSM17468 PTCH1 skin,neck,carcinoma,NS c.584G>T p.R195M 6
3 COSM29053 PTCH1 skin,neck,carcinoma,NS c.833G>A p.W278* 6
4 COSM29072 PTCH1 skin,neck,carcinoma,NS c.1067+1G>A p.? 6
5 COSM14452 PTCH1 skin,neck,carcinoma,NS c.2321G>A p.G774E 6
6 COSM516 KRAS skin,neck,carcinoma,NS c.34G>T p.G12C 6
7 COSM498 HRAS skin,neck,carcinoma,NS c.182A>T p.Q61L 6

Expression for Hidradenocarcinoma

Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for Hidradenocarcinoma

Pathways related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1 12.68 BCL2 CCND1 EGFR ERBB2 ESR1 TP53
2 12.42 CCND1 MKI67 TP53 TP63 VIM
3
Show member pathways
12.4 BCL2 CCND1 ERBB2 ESR1
4
Show member pathways
12.39 CCND1 EGFR ERBB2 TP53
5
Show member pathways
12.34 BCL2 EGFR ERBB2 TP53
6
Show member pathways
12.32 BCL2 CCND1 EGFR ERBB2 ESR1 TP53
7
Show member pathways
12.21 CCND1 EGFR ERBB2 ESR1
8
Show member pathways
12.12 BCL2 CCND1 EGFR ERBB2 TP53
9 12.11 CCND1 EGFR ERBB2 ESR1 TP53
10
Show member pathways
12.05 CCND1 EGFR ERBB2 TP53
11 11.98 BCL2 EGFR TP53 TP63
12 11.98 BCL2 CCND1 EGFR ERBB2 TP53 TP63
13 11.9 CCND1 EGFR TP53 VIM
14
Show member pathways
11.89 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
15 11.87 BCL2 CCND1 ERBB2 TP53
16 11.85 BCL2 CCND1 TP53 VIM
17 11.84 BCL2 CCND1 EGFR ESR1 TP53
18 11.82 BCL2 EGFR ERBB2
19
Show member pathways
11.79 EGFR ERBB2 ESR1 S100B
20 11.78 BCL2 CCND1 TP53
21
Show member pathways
11.77 EGFR ERBB2 ESR1
22 11.65 BCL2 ERBB2 TP53
23
Show member pathways
11.63 CCND1 EGFR ESR1
24 11.59 CCND1 EGFR ESR1
25 11.58 EGFR ERBB2 TP53
26 11.54 BCL2 CCND1 ERBB2
27 11.53 CCND1 EGFR ERBB2 TP53
28 11.16 BCL2 CCND1 EGFR TP53
29
Show member pathways
10.95 BCL2 TP53 TP63
30 10.92 BCL2 EGFR ERBB2 PIP VIM

GO Terms for Hidradenocarcinoma

Cellular components related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.47 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
2 protein complex GO:0043234 9.43 BCL2 CDX2 EGFR ESR1 TP53 TP63

Biological processes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.99 CCND1 CDX2 ESR1 NKX2-1 TP53 TP63
2 regulation of transcription by RNA polymerase II GO:0006357 9.98 CDX2 EGFR ERBB2 ESR1 NKX2-1
3 positive regulation of cell proliferation GO:0008284 9.95 BCL2 CCND1 CDX2 EGFR S100B
4 regulation of apoptotic process GO:0042981 9.93 BCL2 ESR1 TP53 TP63
5 positive regulation of transcription, DNA-templated GO:0045893 9.93 CDX2 EGFR ESR1 NKX2-1 TP53 TP63
6 positive regulation of gene expression GO:0010628 9.88 ERBB2 NKX2-1 PIP TP53 VIM
7 response to estradiol GO:0032355 9.79 CCND1 EGFR ESR1
8 wound healing GO:0042060 9.77 EGFR ERBB2 TP53
9 positive regulation of cell growth GO:0030307 9.71 BCL2 EGFR ERBB2
10 response to glucocorticoid GO:0051384 9.7 BCL2 CCND1 S100B
11 pattern specification process GO:0007389 9.67 CDX2 NKX2-1 TP63
12 digestive tract morphogenesis GO:0048546 9.62 BCL2 EGFR
13 animal organ morphogenesis GO:0009887 9.62 BCL2 CDX2 NKX2-1 TP63
14 negative regulation of ERBB signaling pathway GO:1901185 9.61 EGFR ERBB2
15 regulation of mitochondrial membrane permeability GO:0046902 9.61 BCL2 TP53
16 cerebral cortex cell migration GO:0021795 9.59 EGFR NKX2-1
17 Leydig cell differentiation GO:0033327 9.58 CCND1 NKX2-1
18 response to gamma radiation GO:0010332 9.58 BCL2 TP53 TP63
19 response to UV-B GO:0010224 9.57 BCL2 TP53
20 epithelial cell development GO:0002064 9.56 ESR1 TP63
21 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.54 BCL2 TP53 TP63
22 response to UV-A GO:0070141 9.43 CCND1 EGFR
23 cell aging GO:0007569 9.43 BCL2 TP53 TP63
24 response to X-ray GO:0010165 9.33 CCND1 TP53 TP63
25 cell proliferation GO:0008283 9.17 BCL2 EGFR ERBB2 MKI67 S100B TP53
26 mitotic G1 DNA damage checkpoint GO:0031571 9.13 CCND1 TP53 TP63

Molecular functions related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein C-terminus binding GO:0008022 9.67 ERBB2 MKI67 TP53 VIM
2 enzyme binding GO:0019899 9.65 CCND1 EGFR ESR1 NKX2-1 TP53
3 sequence-specific DNA binding GO:0043565 9.63 BCL2 CDX2 ESR1 NKX2-1 TP53 TP63
4 identical protein binding GO:0042802 9.56 BCL2 EGFR ERBB2 ESR1 S100B TP53
5 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.43 EGFR ERBB2
6 MDM2/MDM4 family protein binding GO:0097371 9.4 TP53 TP63
7 nitric-oxide synthase regulator activity GO:0030235 9.32 EGFR ESR1
8 protein phosphatase binding GO:0019903 8.92 BCL2 EGFR ERBB2 TP53
9 protein binding GO:0005515 10.33 BCL2 CCND1 EGFR ERBB2 ESR1 KRT5

Sources for Hidradenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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