MCID: HDR006
MIFTS: 43

Hidradenocarcinoma malady

Rare diseases, Endocrine diseases, Cancer diseases categories

Summaries for Hidradenocarcinoma

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NIH Rare Diseases:41 Hidradenocarcinoma is a tumor caused by the abnormal growth of cells in a sweat gland.  it is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but it has also been found on other parts of the body.  this type of tumor typically develops in older individuals (after age 40).  each hidradenocarcinoma develops differently over time; some may stay the same size and others grow rapidly.  sometimes it may spread into nearby tissues, or to more distant parts of the body in a process called metastasis.  it is not known why some hidradenocarcinomas progress rapidly while others remain stable. last updated: 9/25/2013

MalaCards based summary: Hidradenocarcinoma, also known as primary mucoepidermoid cutaneous carcinoma, is related to acrospiroma and nephrogenic adenoma. An important gene associated with Hidradenocarcinoma is KRT5 (keratin 5), and among its related pathways are Alzheimers Disease Pathway and Adherens junction. The compounds topotecan and ag 490 have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lymph node, and related mouse phenotypes are craniofacial and no phenotypic analysis.

Wikipedia:63 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Aliases & Classifications for Hidradenocarcinoma

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Hidradenocarcinoma, Aliases & Descriptions:

Name: Hidradenocarcinoma 41
Primary Mucoepidermoid Cutaneous Carcinoma 41
Malignant Nodular/clear Cell Hidradenoma 41
Malignant Clear Cell Acrospiroma 41
 
Clear Cell Eccrine Carcinoma 41
Sweat Gland Adenocarcinoma 60
Eccrine Ductal Carcinoma 60
Malignant Acrospiroma 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Related Diseases for Hidradenocarcinoma

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Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1acrospiroma10.5
2nephrogenic adenoma10.5KRT7
3giant cell glioblastoma10.3EGFR
4pseudomyxoma peritonei10.3KRT7, MUC5AC
5vulvar clear cell hidradenocarcinoma10.3
6hidradenoma10.3
7pancreatic ductal carcinoma10.3KRT7, MUC5AC
8breast fibroadenoma10.3ESR1
9meningioma, familial10.3ESR1
10paget disease, extramammary10.3KRT7, ERBB2
11chordoma10.3KRT5, KRT7
12gallbladder cancer10.3MUC5AC, KRT7
13benign mesothelioma10.2KRT5, TP53
14thymic carcinoma10.2KRT7, TP63
15hypertrophic scars10.2TP63, KRT5
16actinic keratosis10.2TP63, TP53
17stomach cancer10.2ERBB2, TP53
18oxyphilic adenoma10.2KRT7, TP63
19skin benign neoplasm10.2TP63, KRT5
20biliary tract neoplasm10.2ERBB2, EGFR
21pleomorphic adenoma10.2ERBB2, TP63
22neuroendocrine tumor10.2TP63, KRT7
23sweat gland carcinoma10.2
24barrett esophagus/esophageal adenocarcinoma10.1MUC5AC, KRT7, TP53
25brain cancer10.1EGFR, TP53
26leiomyosarcoma10.1TP53, TP63
27mesothelioma, somatic10.1KRT7, KRT5, TP63
28gastritis10.1MUC5AC, TP53
29mesothelioma10.1KRT5, KRT7
30laryngeal carcinoma10.1EGFR, TP53
31breast disease10.1ESR1, ERBB2
32cribriform carcinoma10.1ESR1, TP63
33bronchiolo-alveolar adenocarcinoma10.1KRT7, MUC5AC, EGFR
34abrikosov's tumor10.1ESR1, KRT7
35bladder cancer, somatic10.1ERBB2, TP53
36malignant mixed mullerian tumor10.1ERBB2, TP53, KRT7
37salivary gland adenoid cystic carcinoma10.1KRT7, TP63, ERBB2
38malignant acrospiroma10.0
39clear cell hidradenoma10.0
40nodular hidradenoma10.0
41eccrine porocarcinoma10.0
42pyogenic granuloma10.0
43grade iii astrocytoma10.0EGFR, TP53
44papilloma10.0KRT5, TP53, TP63
45li-fraumeni syndrome10.0ESR1, ERBB2
46pancreatic cancer10.0EGFR, MUC5AC, KRT7
47basal cell carcinoma10.0KRT7, TP53, TP63
48esophageal cancer10.0EGFR, TP53
49oral cancer10.0EGFR, TP53, KRT5
50squamous cell carcinoma, head and neck10.0KRT5, EGFR, TP53

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to hidradenocarcinoma

Symptoms for Hidradenocarcinoma

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Drugs & Therapeutics for Hidradenocarcinoma

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Drug clinical trials:

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Search NIH Clinical Center for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

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Anatomical Context for Hidradenocarcinoma

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MalaCards organs/tissues related to Hidradenocarcinoma:

31
Skin, Breast, Lymph node

Animal Models for Hidradenocarcinoma or affiliated genes

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Publications for Hidradenocarcinoma

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Articles related to Hidradenocarcinoma:

(show all 45)
idTitleAuthorsYear
1
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. (25627632)
2015
2
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. (25815059)
2015
3
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. (25513929)
2014
4
Hidradenocarcinoma of the chest. (25382529)
2014
5
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. (25006935)
2014
6
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. (24490986)
2014
7
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. (23489214)
2013
8
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. (22998159)
2013
9
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. (23466792)
2013
10
Hidradenocarcinoma of the Finger. (23486133)
2013
11
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. (23053773)
2013
12
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. (22678002)
2012
13
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. (23271300)
2012
14
No sweat, a rare case of hidradenocarcinoma. (22369809)
2012
15
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. (21892057)
2011
16
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. (21844475)
2011
17
Hidradenocarcinoma of the fingertip: a case report and literature review. (21489038)
2011
18
Radiotherapy on hidradenocarcinoma. (22540063)
2011
19
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. (21044227)
2010
20
Perianal nodular hidradenocarcinoma. Case report. (20478121)
2010
21
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. (20572504)
2010
22
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. (19522717)
2010
23
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. (19476529)
2009
24
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (20596988)
2009
25
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. (19384064)
2009
26
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. (19215270)
2009
27
Metastatic hidradenocarcinoma: Surgery and chemotherapy. (22666726)
2009
28
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. (20740144)
2009
29
Clear cell hidradenocarcinoma developing in pacemaker pocket. (18950311)
2008
30
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. (17214855)
2007
31
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. (17103407)
2007
32
Hidradenocarcinoma: a histological and immunohistochemical study. (17083691)
2006
33
Metastatic hidradenocarcinoma: efficacy of capecitabine. (17043204)
2006
34
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. (15355375)
2004
35
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. (10955691)
2000
36
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
37
Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. (8626149)
1996
38
Metastatic clear-cell hidradenocarcinoma of the vulva. (8428700)
1993
39
Clear cell hidradenocarcinoma--a case report with unusual in situ malignant changes. (6328124)
1984
40
Eccrine hidradenocarcinoma of the vulva with Paget's disease. Case report with a review of the literature. (6295435)
1983
41
Clear cell hidradenocarcinoma. Report of an unusual case. (190056)
1976
42
Hidradenocarcinoma: report of a case. (4310623)
1969
43
Clear cell hidradenoma and hidradenocarcinoma. (14032110)
1963
44
A clear-cell hidradenocarcinoma with metastases. (13472651)
1957
45
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952

Variations for Hidradenocarcinoma

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Expression for genes affiliated with Hidradenocarcinoma

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Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for genes affiliated with Hidradenocarcinoma

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Pathways related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6EGFR, ERBB2
29.6EGFR, ERBB2
3
Show member pathways
9.6ERBB2, EGFR
49.6ERBB2, EGFR
5
Show member pathways
9.6ERBB2, EGFR
69.6ERBB2, EGFR
79.6KRT5, KRT7
8
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway58
9.5EGFR, ESR1
99.5EGFR, ESR1
10
Show member pathways
9.4TP63, TP53
119.4EGFR, TP53
129.3ESR1, TP53
139.3TP53, ESR1
14
Show member pathways
9.1EGFR, ERBB2, ESR1
15
Show member pathways
9.1EGFR, ERBB2, ESR1
16
Show member pathways
Development Ligand independent activation of ESR1 and ESR258
9.1EGFR, ERBB2, ESR1
17
Show member pathways
Signaling Pathways in Glioblastoma36
9.0EGFR, ERBB2, TP53
18
Show member pathways
9.0EGFR, ERBB2, TP53
199.0EGFR, ERBB2, TP53
209.0EGFR, ERBB2, TP53
21
Show member pathways
9.0EGFR, ERBB2, TP53
22
Show member pathways
9.0TP53, ERBB2, EGFR
239.0TP53, ERBB2, EGFR
24
Show member pathways
9.0TP53, ERBB2, EGFR
25
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.0TP53, ERBB2, EGFR
26
Show member pathways
Signal transduction PTEN pathway58
9.0TP53, ERBB2, EGFR
279.0EGFR, TP53, TP63
288.9EGFR, ESR1, TP53
298.6EGFR, ERBB2, TP53, TP63
308.5EGFR, ERBB2, ESR1, TP53
318.5TP53, ESR1, ERBB2, EGFR
32
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
8.5TP53, ESR1, ERBB2, EGFR
33
Show member pathways
8.5TP53, ESR1, ERBB2, EGFR
34
Show member pathways
8.5TP53, ESR1, ERBB2, EGFR

Compounds for genes affiliated with Hidradenocarcinoma

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Compounds related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1topotecan43 1211.4EGFR
2ag 490599.9ERBB2, EGFR
3jnj 28871063 hydrochloride599.9EGFR, ERBB2
4alkylating agents499.9EGFR, ESR1
5afatinib49 1210.9EGFR, ERBB2
6ag 1478 hydrochloride599.9ERBB2, EGFR
7iressa599.8ERBB2, EGFR
8pd158780439.8ERBB2, EGFR
9ag 1478439.8MUC5AC
10pertuzumab43 49 1211.6EGFR, ERBB2
11anastrozole43 49 1211.5ESR1, ERBB2, EGFR
12exemestane43 49 59 1212.5ESR1, ERBB2, EGFR
13everolimus43 49 1211.5ESR1, ERBB2, EGFR
14lapatinib43 49 1211.5ESR1, ERBB2, EGFR
15fulvestrant43 49 28 1212.5EGFR, ERBB2, ESR1
16letrozole43 49 59 1212.5ESR1, ERBB2, EGFR
17trastuzumab43 49 1211.4ESR1, ERBB2, EGFR
184-hydroxytamoxifen439.4ESR1, ERBB2, EGFR
19suberoylanilide hydroxamic acid439.4TP53, ERBB2, EGFR
20oxaliplatin43 49 1211.4EGFR, ERBB2, TP53
21radicicol43 59 1211.4ERBB2, ESR1, TP53
22flavopiridol43 1210.4EGFR, ERBB2, TP53
23n-(4-hydroxyphenyl)retinamide439.3TP53, ESR1, ERBB2
24bortezomib43 49 1211.3EGFR, ERBB2, TP53
25gefitinib43 49 1211.2ESR1, ERBB2, EGFR
26hematoxylin439.0KRT7, MUC5AC, TP63
27progestin439.0ESR1, ERBB2, EGFR
28irinotecan43 49 1211.0EGFR, ERBB2, TP53
29taxane438.9TP53, ESR1, ERBB2, EGFR
30geldanamycin43 49 59 1211.9EGFR, ERBB2, ESR1, TP53
31docetaxel43 49 59 1211.9EGFR, ERBB2, ESR1, TP53
32genistein43 28 59 2 24 1213.9EGFR, KRT5, ERBB2, ESR1
33tamoxifen43 49 28 1211.9EGFR, ERBB2, ESR1, TP53
34paclitaxel43 49 1210.8TP53, ESR1, ERBB2, EGFR
35ly294002438.8EGFR, ERBB2, ESR1, TP53
36carboplatin43 49 1210.7EGFR, ERBB2, TP53
37methotrexate49 43 1210.6ESR1, MUC5AC, ERBB2, KRT7
38n acetylcysteine438.6EGFR, ERBB2, MUC5AC, TP53
39arginine438.6TP63, TP53, ERBB2, KRT7, KRT5
40doxorubicin43 49 1210.5TP63, TP53, ESR1, ERBB2, EGFR
41cisplatin43 49 59 1211.5TP63, TP53, ESR1, ERBB2, EGFR
425fluorouracil438.1TP53, ESR1, MUC5AC, ERBB2, EGFR
43vegf438.0TP63, TP53, ESR1, ERBB2, KRT7, EGFR
44tyrosine437.9TP63, MUC5AC, ERBB2, KRT7, KRT5, EGFR
45retinoid437.6TP53, ESR1, MUC5AC, KRT7, KRT5, EGFR
46testosterone43 59 24 1210.5TP63, ESR1, MUC5AC, ERBB2, KRT7, KRT5
47retinoic acid43 248.2TP63, TP53, ESR1, MUC5AC, KRT7, KRT5
48paraffin436.9EGFR, TP63, TP53, ESR1, MUC5AC, ERBB2
49progesterone43 28 59 24 1210.9TP63, TP53, ESR1, MUC5AC, ERBB2, KRT7
50estrogen436.8TP63, TP53, ESR1, MUC5AC, ERBB2, KRT7

GO Terms for genes affiliated with Hidradenocarcinoma

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Cellular components related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:00007859.4TP53, TP63
2cytoplasmGO:00057377.4EGFR, KRT5, KRT7, ERBB2, TP53, TP63

Biological processes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell developmentGO:00020649.9ESR1, TP63
2cellular response to estradiol stimulusGO:00713929.8EGFR, ESR1
3mitotic G1 DNA damage checkpointGO:00315719.8TP53, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.8TP63, TP53
5positive regulation of nitric oxide biosynthetic processGO:00454299.7ESR1, EGFR
6response to X-rayGO:00101659.7TP53, TP63
7cell agingGO:00075699.7TP63, TP53
8positive regulation of MAP kinase activityGO:00434069.7ERBB2, EGFR
9response to gamma radiationGO:00103329.7TP53, TP63
10intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.7TP63, TP53
11cellular response to UVGO:00346449.6TP53, TP63
12neuron apoptotic processGO:00514029.6TP53, TP63
13positive regulation of fibroblast proliferationGO:00481469.6EGFR, ESR1
14positive regulation of epithelial cell proliferationGO:00506799.5EGFR, ERBB2
15cellular response to drugGO:00356909.4EGFR, TP53
16chromatin remodelingGO:00063389.2TP63, ESR1
17cell proliferationGO:00082839.2TP53, ERBB2, EGFR
18negative regulation of apoptotic processGO:00430669.0EGFR, TP53, TP63
19positive regulation of transcription from RNA polymerase II promoterGO:00459448.8TP63, TP53, ESR1, EGFR

Molecular functions related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00050069.9ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:00047169.8EGFR, ERBB2
3transmembrane receptor protein tyrosine kinase activityGO:00047149.7EGFR, ERBB2
4nitric-oxide synthase regulator activityGO:00302359.7EGFR, ESR1
5damaged DNA bindingGO:00036849.4TP63, TP53
6RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:00010779.4TP53, TP63
7protein phosphatase bindingGO:00199039.3EGFR, ERBB2, TP53
8p53 bindingGO:00020399.1TP53, TP63
9enzyme bindingGO:00198999.0EGFR, ESR1, TP53
10protein heterodimerization activityGO:00469828.9EGFR, ERBB2, TP53
11chromatin bindingGO:00036828.7TP63, TP53, ESR1, EGFR
12identical protein bindingGO:00428028.4EGFR, ERBB2, ESR1, TP53, TP63
13protein bindingGO:00055157.4TP63, TP53, ESR1, ERBB2, KRT7, KRT5

Products for genes affiliated with Hidradenocarcinoma

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Sources for Hidradenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
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46OMIM via Orphanet
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51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet