MCID: HDR004
MIFTS: 47

Hidradenoma malady

Skin diseases, Endocrine diseases, Cancer diseases categories

Summaries for Hidradenoma

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Wikipedia:63 Hidradenoma(also known as acrospiroma, from akral \"peripheral\" + spiroma \"epithelial tumor of sweat... more...

MalaCards based summary: Hidradenoma, also known as benign neoplasm of sweat gland, is related to clear cell hidradenoma and syringocystadenoma papilliferum. An important gene associated with Hidradenoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are Alzheimers Disease Pathway and SHC1 events in ERBB2 signaling. The compounds ag 1478 and eosin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and salivary gland, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Hidradenoma

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Sources:
60UMLS, 9Disease Ontology, 11DISEASES, 43Novoseek, 55SNOMED-CT, 33MeSH, 38NCIt
See all sources

Hidradenoma, Aliases & Descriptions:

Name: Hidradenoma 9 11 43
Benign Neoplasm of Sweat Gland 60
Hidradenoma Morphology 9
Adenoma, Sweat Gland 60
 
Eccrine Acrospiroma 60
Hidradenoma of Skin 9
Sweat Gland Adenoma 9
Syringoadenoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Endocrine diseases


External Ids:

Disease Ontology9 DOID:3896
MeSH33 D006607
NCIt38 C7560, C7563

Related Diseases for Hidradenoma

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Diseases related to Hidradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell hidradenoma32.1SGTA
2syringocystadenoma papilliferum30.8PIP, CLEC2A
3syringoma30.7MUC1
4glomus tumor30.6VIM
5mucoepidermoid carcinoma30.4CRTC1, MAML2
6hidrocystoma30.4PIP, SGTA
7adenosquamous carcinoma30.3MUC1, EGFR
8ductal carcinoma in situ30.0EGFR, ERBB2
9pleomorphic adenoma29.9ERBB2, VIM, MUC1
10breast cancer29.7PIP, ERBB2, EGFR
11adenocarcinoma29.3EGFR, PIP, VIM, CREB1, MUC1, ERBB2
12nodular hidradenoma10.8
13papillary hidradenoma10.5
14cystadenocarcinoma10.5MUC1
15adenomatoid tumor10.5VIM
16renal cell carcinoma10.4EGFR
17hidradenocarcinoma10.4
18giant cell glioblastoma10.4EGFR
19fibrous histiocytoma10.4CREB1
20cervical adenosquamous carcinoma10.4MAML2, CRTC1
21lacrimal gland cancer10.4CRTC1, MAML2
22cutaneous mucoepidermoid carcinoma10.4MAML2, CRTC1
23lipoadenoma10.4CRTC1, MAML2
24necrotizing sialometaplasia10.4CRTC1, MAML2
25clear cell ependymoma10.4MUC1, VIM
26epithelial-myoepithelial carcinoma10.4CRTC1, MAML2
27mesenchymal chondrosarcoma10.4VIM, MUC1
28spindle cell carcinoma10.3VIM, MUC1
29spindle cell sarcoma10.3VIM, MUC1
30epithelioid sarcoma10.3MUC1, VIM
31sertoli cell tumor10.3MUC1, VIM
32dermatofibrosarcoma protuberans10.3MUC1, VIM
33secretory meningioma10.3VIM, MUC1
34rhabdoid tumor10.3VIM, MUC1
35perineurioma10.3VIM, MUC1
36hemangiopericytoma10.3VIM, MUC1
37sex cord-gonadal stromal tumor10.3VIM, MUC1
38chordoma10.3VIM, MUC1
39angiosarcoma10.3MUC1, VIM
40abrikosov's tumor10.3VIM, MUC1
41giant cell tumor10.3VIM, MUC1
42neurofibroma10.3MUC1, VIM
43malignant fibroxanthoma10.3VIM, MUC1
44vulvar nodular hidradenoma10.3
45oxyphilic adenoma10.2MUC1, VIM
46sarcoma, synovial10.2MUC1, VIM
47renal clear cell carcinoma10.2VIM, MUC1
48malignant peripheral nerve sheath tumor10.2EGFR, VIM
49eccrine acrospiroma10.2
50leiomyosarcoma10.2MUC1, VIM

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to hidradenoma

Symptoms for Hidradenoma

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Drugs & Therapeutics for Hidradenoma

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Drug clinical trials:

Search ClinicalTrials for Hidradenoma

Search NIH Clinical Center for Hidradenoma

Genetic Tests for Hidradenoma

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Anatomical Context for Hidradenoma

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MalaCards organs/tissues related to Hidradenoma:

31
Skin, Breast, Salivary gland, Lymph node, Heart, Smooth muscle

Animal Models for Hidradenoma or affiliated genes

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MGI Mouse Phenotypes related to Hidradenoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1EGFR, ERBB2, CRTC1, CREB1, MUC1, VIM
2MP:00053797.9EGFR, ERBB2, CRTC1, CREB1, MUC1, PIP
3MP:00053897.8PIP, VIM, CREB1, CRTC1, ERBB2, EGFR
4MP:00053857.6PIP, VIM, CREB1, CRTC1, ERBB2, EGFR

Publications for Hidradenoma

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Articles related to Hidradenoma:

(show top 50)    (show all 251)
idTitleAuthorsYear
1
Nodular hidradenoma of left toe. (25671057)
2015
2
What is your diagnosis? Clear cell hidradenoma. (25566574)
2014
3
Nodular hidradenoma of the scalp: A cytomorphological evaluation on fine needle aspiration cytology. (25382530)
2014
4
A case of tubulopapillary hidradenoma on the face. (25269926)
2014
5
Giant eccrine hidradenoma mimicking a malignant tumor of the salivary gland. (25075376)
2014
6
Hidradenoma papilliferum, diagnostic challenge: a case. (25387849)
2014
7
Malignant nodular hidradenoma of scalp. (25288856)
2014
8
Hidradenoma papilliferum of the orbit. (23387456)
2013
9
Nodular Hidradenoma of the Caruncle. (23715517)
2013
10
Benign hidradenoma masquerading as ductal breast cancer-a rare case of false-positive recurrence in cancer follow-up. (24102904)
2013
11
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
12
Hidradenoma papilliferum presenting as an eyelid mass. (22820442)
2012
13
Benign nodular hidradenoma of the face. (21415656)
2011
14
Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report. (21053567)
2010
15
From hidroacanthoma simplex to poroid hidradenoma: clinicopathologic and immunohistochemic study of poroid neoplasms and reappraisal of their histogenesis. (20571345)
2010
16
Fine-needle aspiration cytology of apocrine hidradenoma. (20698151)
2010
17
Clear cell hidradenoma of the axilla: a case report with literature review. (20592936)
2010
18
Giant benign nodular hidradenoma of the shoulder: A rare tumor in orthopedic practice. (21655004)
2010
19
Clear cell hidradenoma of the gluteal region: a case report. (19595274)
2009
20
Nodular hidradenoma of the breast: A case report with literature review. (23133109)
2009
21
Giant ectopic hidradenoma papilliferum on the scalp. (19785709)
2009
22
Dermoscopic features of clear cell hidradenoma. (18663309)
2008
23
Poroid hidradenoma: a case report with review of Japanese published work. (17584332)
2007
24
Clear cell hidradenoma of the ankle. (17761324)
2007
25
Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. 2005;43:202-205. (16670462)
2006
26
Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion. (15729701)
2005
27
Asymptomatic slowly enlarging nodule on the trunk: eccrine hidradenoma. (15009319)
2004
28
Vulvar poroid hidradenoma. (12454609)
2002
29
Malignant nodular hidradenoma in a patient with neurofibromatosis type 1: a case report and review of the literature. (11710446)
2001
30
Extramammary Paget disease with underlying hidradenoma papilliferum: guilt by association? (11048981)
2000
31
Vulvar hidradenoma papilliferum. A review of 10.5 years' experience. (10986678)
2000
32
Malignant nodular hidradenoma of nose. (23119494)
1999
33
Ectopic hidradenoma papilliferum: a case report and review of the literature. (10411423)
1999
34
Fine needle aspiration cytology of poroid hidradenoma. (9684613)
1998
35
Clear cell hidradenoma simulating breast carcinoma: a diagnostic pitfall in fine-needle aspiration of breast. (8807256)
1996
36
Fine-needle aspiration diagnosis of a vulvar papillary hidradenoma: a case report. (8005045)
1994
37
Cytogenetic heterogeneity in a clear cell hidradenoma of the skin. (7923079)
1994
38
Clear cell hidradenoma: a tumor with basaliomatous changes in the overlying epidermis and follicular infundibula of surrounding skin. (1328338)
1992
39
Eccrine acrospiroma (clear cell hidradenoma) of the eyelid. Immunohistochemical and ultrastructural features. (1708858)
1991
40
Malignant hidradenoma--a case report demonstrating insidious histological and clinical progression. (1666865)
1991
41
Clear cell hidradenoma. A case report. (2176689)
1990
42
Combined papillary syringocystadenoma and hidradenoma. A case study. (198458)
1977
43
Syringeal hidradenoma--an unusual eccrine tumour. (4109429)
1971
44
Clear cell hidradenoma of the eyelid. (4298541)
1968
45
HIDRADENOMA OF THE ANAL CANAL. (14280233)
1965
46
Clear-cell hidradenoma. (13588473)
1958
47
Hidradenoma of the vulva. (14933503)
1952
48
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952
49
Hidradenoma of the vulva. (14782694)
1950
50
Hidradenoma of the vulva. (18106314)
1948

Variations for Hidradenoma

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Expression for genes affiliated with Hidradenoma

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Search GEO for disease gene expression data for Hidradenoma.

Pathways for genes affiliated with Hidradenoma

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Pathways related to Hidradenoma according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7EGFR, ERBB2
2
Show member pathways
9.7ERBB2, EGFR
39.7ERBB2, EGFR
49.7ERBB2, EGFR
5
Show member pathways
9.7CREB1, MAML2
69.4MUC1, ERBB2, EGFR
7
Show member pathways
9.4EGFR, ERBB2, VIM
89.4EGFR, ERBB2, VIM
9
Show member pathways
9.3CREB1, ERBB2, EGFR
10
Show member pathways
Development Ligand independent activation of ESR1 and ESR258
9.3CREB1, ERBB2, EGFR
119.3CREB1, ERBB2, EGFR
12
Show member pathways
9.3EGFR, ERBB2, CREB1
13
Show member pathways
9.3EGFR, ERBB2, CREB1
14
Show member pathways
9.3EGFR, ERBB2, CREB1
15
Show member pathways
Signaling Pathways in Glioblastoma36
9.3EGFR, ERBB2, CREB1
16
Show member pathways
9.3EGFR, ERBB2, CREB1
17
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.3EGFR, ERBB2, CREB1
18
Show member pathways
9.3EGFR, ERBB2, CREB1
19
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
9.0EGFR, ERBB2, CREB1, MUC1
208.9EGFR, ERBB2, CREB1, MAML2
21
Show member pathways
8.8PIP, CREB1, ERBB2, EGFR
22
Show member pathways
8.8EGFR, ERBB2, CREB1, PIP
23
Show member pathways
8.2PIP, VIM, MUC1, CREB1, ERBB2, EGFR

Compounds for genes affiliated with Hidradenoma

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Compounds related to Hidradenoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1ag 14784310.5CREB1
2eosin4310.2MUC1, VIM
3s 1004310.2MUC1, VIM
4pd1587804310.1EGFR, ERBB2
5jnj 28871063 hydrochloride5910.1EGFR, ERBB2
6afatinib49 1211.1EGFR, ERBB2
7ag 1478 hydrochloride5910.1ERBB2, EGFR
8ag 4905910.1EGFR, ERBB2
9iressa5910.1ERBB2, EGFR
10pertuzumab43 49 1212.1ERBB2, EGFR
11pki-1664310.0ERBB2, EGFR
12hrgbeta14310.0EGFR, ERBB2
13quinazoline4310.0ERBB2, EGFR
14reticulin4310.0MUC1, VIM
15erbstatin439.9ERBB2, EGFR
16ganciclovir43 1210.9ERBB2, VIM, CREB1
17trastuzumab43 49 1211.8ERBB2, MUC1, EGFR
18biotin43 24 1211.8VIM, ERBB2, MUC1
19hydrocortisone43 2 59 1212.8MUC1, VIM, ERBB2
20mucicarmine439.8MUC1, VIM, PIP
21adriamycin439.8ERBB2, MUC1, VIM
22b 723439.8MUC1, VIM, PIP
234-hydroxytamoxifen439.8EGFR, VIM, ERBB2
24capecitabine43 49 1211.8ERBB2, EGFR
25gemcitabine43 49 1211.8EGFR, MUC1, ERBB2
26gefitinib43 49 1211.7EGFR, VIM, ERBB2
27anastrozole43 49 1211.7EGFR, ERBB2
28pd153035439.7ERBB2, EGFR
29thymidylate439.7EGFR, ERBB2, VIM
30formaldehyde43 2410.7ERBB2, MUC1, VIM
31dihydrotestosterone43 28 24 1212.6PIP, VIM, MUC1
32folate439.6VIM, MUC1, ERBB2
33exemestane43 49 59 1212.6ERBB2, EGFR
34herbimycin a43 5910.6EGFR, CREB1, ERBB2
35chloramphenicol43 2 49 1212.6VIM, MUC1, ERBB2, CREB1
36curcumin439.5CREB1, EGFR, ERBB2
37progestin439.5ERBB2, MUC1, EGFR, VIM
38rapamycin439.4EGFR, CREB1, VIM, ERBB2
39genistein43 28 59 2 24 1214.4VIM, CREB1, ERBB2, EGFR
40everolimus43 49 1211.4ERBB2, EGFR
41estradiol43 24 1211.4PIP, VIM, MUC1, CREB1
42cycloheximide439.3VIM, EGFR, ERBB2, CREB1
43agar439.2VIM, EGFR, ERBB2, MUC1, CREB1
44cyclic amp43 2410.2CREB1, MUC1, VIM, CRTC1
45vegf439.2MUC1, ERBB2, EGFR, VIM, CREB1
46tamoxifen43 49 28 1212.0VIM, EGFR, ERBB2, MUC1, PIP
47paraffin439.0PIP, ERBB2, EGFR, MUC1, VIM
48progesterone43 28 59 24 1213.0PIP, MUC1, VIM, ERBB2, EGFR
49testosterone43 59 24 1211.7VIM, MUC1, CREB1, ERBB2, EGFR, PIP
50estrogen438.6VIM, EGFR, PIP, ERBB2, CREB1, MUC1

GO Terms for genes affiliated with Hidradenoma

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Cellular components related to Hidradenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163248.9EGFR, ERBB2, MUC1, PIP

Biological processes related to Hidradenoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription by competitive promoter bindingGO:001094410.1CREB1, MUC1
2positive regulation of MAP kinase activityGO:00434069.7ERBB2, EGFR
3positive regulation of epithelial cell proliferationGO:00506799.7EGFR, ERBB2
4phosphatidylinositol-mediated signalingGO:00480159.6EGFR, ERBB2, CREB1
5fibroblast growth factor receptor signaling pathwayGO:00085439.5EGFR, ERBB2, CREB1
6Fc-epsilon receptor signaling pathwayGO:00380959.5EGFR, ERBB2, CREB1
7epidermal growth factor receptor signaling pathwayGO:00071739.5CREB1, ERBB2, EGFR
8activation of phospholipase C activityGO:00072029.4EGFR, CREB1
9neurotrophin TRK receptor signaling pathwayGO:00480119.4EGFR, ERBB2, CREB1
10axon guidanceGO:00074119.2EGFR, ERBB2, CREB1
11viral processGO:00160328.9SGTA, VIM, CREB1, CRTC1
12positive regulation of transcription from RNA polymerase II promoterGO:00459448.8EGFR, CRTC1, CREB1, MAML2

Molecular functions related to Hidradenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription cofactor activityGO:00037129.8CREB1, MUC1
2epidermal growth factor-activated receptor activityGO:00050069.8EGFR, ERBB2
3receptor signaling protein tyrosine kinase activityGO:00047169.7ERBB2, EGFR
4transmembrane receptor protein tyrosine kinase activityGO:00047149.4EGFR, ERBB2
5glycoprotein bindingGO:00019489.3EGFR, VIM, PIP
6protein bindingGO:00055156.7SGTA, CLEC2A, VIM, MUC1, CREB1, CRTC1

Products for genes affiliated with Hidradenoma

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Sources for Hidradenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet