MCID: HDR004
MIFTS: 48

Hidradenoma malady

Skin diseases, Endocrine diseases categories

Summaries for Hidradenoma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Hidradenoma is a cutaneous condition, primarily occurring in adult women, that is a form of benign... more...

MalaCards: Hidradenoma, also known as hidradenoma morphology, is related to clear cell hidradenoma and syringocystadenoma papilliferum. An important gene associated with Hidradenoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are EGFR Signaling Pathway and Alpha6-Beta4 Integrin Signaling Pathway. The compounds hematoxylin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and salivary gland.

Aliases & Classifications for Hidradenoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Endocrine diseases


Aliases & Descriptions:

hidradenoma 8 10 44
hidradenoma morphology 8
adenoma, sweat gland 60
sweat gland adenoma 8
hidradenoma of skin 8
syringocystadenoma 60
syringoadenoma 8


External Ids:

Disease Ontology8 DOID:3896
MeSH34 D006607
NCIt39 C7560, C7563

Related Diseases for Hidradenoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hidradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell hidradenoma31.2SGTA
2syringocystadenoma papilliferum30.3CLEC2A, PIP
3adenocarcinoma30.2VIM, S100A6, PIP, CREB1, EGFR, MUC1
4adenoma30.0S100A6, CREB1, MUC1
5syringoma29.8MUC1
6spiradenoma29.8CLEC2A
7neurofibromatosis29.8CREB1
8hidrocystoma29.8SGTA, PIP
9ductal carcinoma in situ29.8ERBB2, EGFR
10pleomorphic adenoma29.8VIM, MUC1, ERBB2
11squamous cell carcinoma29.8VIM, S100A6, PIP, EGFR, MUC1, KRT10
12mucoepidermoid carcinoma29.8CRTC1, CREB1, EGFR, MAML2, MUC1
13breast cancer29.8AZGP1, VIM, S100A6, PIP, EGFR, MUC1
14nodular hidradenoma10.7
15papillary hidradenoma10.5
16apocrine adenoma10.4
17procarcinoma10.2
18eccrine acrospiroma10.1
19vulvar nodular hidradenoma10.1
20cystadenoma10.0
21myoepithelioma10.0
22nodular malignant melanoma10.0
23adenocarcinoma in situ10.0
24melanoma10.0
25vulva adenocarcinoma10.0
26acrospiroma10.0
27thymus cancer10.0MUC1
28papilloma10.0KRT10
29hemangioblastoma10.0MUC1
30wilms tumor10.0VIM
31angiomyolipoma10.0VIM
32cervical adenosquamous carcinoma10.0CRTC1, MAML2
33epithelial-myoepithelial carcinoma10.0MAML2, CRTC1
34alopecia10.0CLEC2A
35cervical squamous cell carcinoma10.0KRT10
36cutaneous mucoepidermoid carcinoma10.0CRTC1, MAML2
37lacrimal gland cancer10.0CRTC1, MAML2
38lipoadenoma10.0CRTC1, MAML2
39esophageal cancer10.0EGFR
40necrotizing sialometaplasia10.0CRTC1, MAML2
41acanthoma10.0CLEC2A
42fibrosarcoma10.0VIM
43clear cell ependymoma10.0MUC1, VIM
44mesenchymal chondrosarcoma10.0VIM, MUC1
45spindle cell carcinoma10.0MUC1, VIM
46neurofibroma10.0MUC1, VIM
47giant cell glioblastoma10.0EGFR
48spindle cell sarcoma10.0VIM, MUC1
49clear cell sarcoma10.0CREB1
50rhabdoid tumor10.0VIM, MUC1

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to hidradenoma

Clinical Features for Hidradenoma

About this section

Drugs & Therapeutics for Hidradenoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hidradenoma

Drug clinical trials:

Search ClinicalTrials for Hidradenoma

Search NIH Clinical Center for Hidradenoma

Search CenterWatch for Hidradenoma

Genetic Tests for Hidradenoma

About this section

Anatomical Context for Hidradenoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Hidradenoma:

32
Skin, Breast, Salivary gland, Lymph node, Heart, Smooth muscle

Animal Models for Hidradenoma or affiliated genes

About this section

Publications for Hidradenoma

About this section
Sources:
50PubMed
See all sources

Articles related to Hidradenoma:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Rapidly proliferating apocrine hidradenoma treated using Mohs micrographic surgery. (23895228)
2013
2
A study of histopathologic spectrum of nodular hidradenoma. (21993337)
2012
3
Cytomorphological spectrum of a nodular hidradenoma in a young girl presenting with an inguinal soft tissue mass. (20653720)
2011
4
Hidradenoma papilliferum occurring on the nasal skin. (22148064)
2011
5
From hidroacanthoma simplex to poroid hidradenoma: clinicopathologic and immunohistochemic study of poroid neoplasms and reappraisal of their histogenesis. (20571345)
2010
6
Fine-needle aspiration cytology of apocrine hidradenoma. (20698151)
2010
7
Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor. (21180442)
2010
8
Giant clear cell hidradenoma of the knee. (19615032)
2010
9
Clear cell hidradenoma of the gluteal region: a case report. (19595274)
2009
10
Tubulopapillary hidradenoma-like tumor of the mandible. (19375892)
2009
11
Clear-cell hidradenoma in a child: a diagnostic dilemma for the cytopathologist. (19459171)
2009
12
Nodular hidradenoma masquerading an epidermal cyst. (18070023)
2008
13
A giant atypical hidradenoma on the neck. (18637811)
2008
14
Clear cell hidradenoma of the ankle. (17761324)
2007
15
Clear cell hidradenoma of the breast: a case report with review of the literature. (17690510)
2007
16
Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. (17334997)
2007
17
Mohs micrographic surgery, sentinel lymph node mapping, and estrogen receptor analysis for the treatment of malignant nodular hidradenoma. (17034384)
2006
18
Non-anogenital (ectopic) hidradenoma papilliferum with sebaceous differentiation: a case report and review of reported cases. (16674789)
2006
19
Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion. (15729701)
2005
20
Clear-cell hidradenoma of the forearm in a young boy. (16191000)
2005
21
Hidradenoma papilliferum with oxyphilic metaplasia: a clinicopathological study of 18 cases, including detection of human papillomavirus. (15798433)
2005
22
Asymptomatic slowly enlarging nodule on the trunk: eccrine hidradenoma. (15009319)
2004
23
Malignant eccrine hidradenoma of neck causing acute heart failure. (12927299)
2003
24
Hidradenoma papilliferum of nasal skin. (12562260)
2003
25
Clear cell hidradenoma in a young girl. (10727324)
2000
26
Recurrent clear cell hidradenoma of the foot. (10886280)
2000
27
Clear cell hidradenoma of the eyelid: a case report. (10862299)
1999
28
Fine needle aspiration cytology of poroid hidradenoma. (9684613)
1998
29
Management of a hidradenoma with Mohs micrographic surgery. (8089362)
1994
30
Malignant clear cell hidradenoma of the upper lip. (7960742)
1994
31
Malignant clear cell hidradenoma. (8390315)
1993
32
Eccrine acrospiroma (clear cell hidradenoma) of the eyelid. Immunohistochemical and ultrastructural features. (1708858)
1991
33
Clear cell hidradenoma. A case report. (2176689)
1990
34
Hidradenoma papilliferum of the vulva: report of a case characterized by unusual clinical behavior. (2163410)
1990
35
Vulvar adenosquamous carcinoma arising in a hidradenoma papilliferum, with rapidly fatal outcome: case report. (2557272)
1989
36
Metastatic malignant clear cell hidradenoma associated with bullous pemphigoid. (2840942)
1988
37
Nodular hidradenoma: an eccrine sweat gland analog of pleomorphic adenomas of salivary gland origin. (2432207)
1987
38
Malignant clear cell hidradenoma: a case report. (6179349)
1982
39
Hidradenoma papilliferum of the external auditory canal. (6267150)
1981
40
Hidradenoma papilliferum of the eyelid. (6257184)
1981
41
A rare case of hidradenoma papilliferum: report of a case and review of the literature. (4371897)
1974
42
Solid hidradenoma. (4311553)
1969
43
Superficial hidradenoma and basal-cell carcinoma. (4290147)
1966
44
Hidradenoma papilliferum. (14472046)
1962
45
Hidradenoma of the external auditory meatus (so-called ceruminoma). Report of a case. (13761597)
1961
46
Hidradenoma of the external auditory meatus associated with facial palsy and chronic otitis media. (14478311)
1961
47
Clearcell hidradenoma; report of three cases with widespread metastases. (13199772)
1954
48
Hidradenoma of the vulva. (14933503)
1952
49
Mucin-secreting tumours of the skin with special reference to the so-called mixed-salivary tumour of the skin and its relation to hidradenoma. (13000598)
1952
50
Hidradenoma of the vulva. (14782694)
1950

Genetic Variations for Hidradenoma

About this section

Expression for genes affiliated with Hidradenoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hidradenoma

Search GEO for disease gene expression data for Hidradenoma.

Pathways for genes affiliated with Hidradenoma

About this section
Sources:
55SinoBiological, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
See all sources

Compounds for genes affiliated with Hidradenoma

About this section
Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Hidradenoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1hematoxylin4410.4KRT10, VIM
2s 1004410.4VIM, MUC1
3Afatinib1110.3EGFR, ERBB2
4jnj 28871063 hydrochloride5910.3EGFR, ERBB2
5ag 4905910.3EGFR, ERBB2
6ag 1478 hydrochloride5910.3EGFR, ERBB2
7iressa5910.3EGFR, ERBB2
8pd1587804410.3EGFR, ERBB2
9pertuzumab44 49 1112.3EGFR, ERBB2
10pki-1664410.3EGFR, ERBB2
11hrgbeta14410.3EGFR, ERBB2
12eosin4410.3KRT10, MUC1, VIM
13quinazoline4410.3EGFR, ERBB2
14erbstatin4410.2EGFR, ERBB2
15everolimus49 44 1112.1EGFR, ERBB2
16reticulin4410.1VIM, MUC1
17pd1530354410.1EGFR, KRT10, ERBB2
18trastuzumab44 49 1112.1EGFR, MUC1, ERBB2
19ganciclovir44 1111.1ERBB2, CREB1, VIM
20anastrozole44 1111.0EGFR, ERBB2
214-hydroxytamoxifen4410.0ERBB2, EGFR, VIM
22gemcitabine44 49 1112.0EGFR, MUC1, ERBB2
23biotin44 11 2412.0ERBB2, MUC1, VIM
24gefitinib44 49 1112.0ERBB2, EGFR, VIM
25ag 14784410.0ERBB2, EGFR, CREB1
26bexarotene44 28 1112.0EGFR, KRT10
27polyethylene glycol449.9AZGP1, MUC1, ERBB2
28gf 109203x44 5910.9CREB1, EGFR, KRT10
29chloramphenicol44 2 1111.9ERBB2, MUC1, CREB1, VIM
30thymidylate449.9VIM, EGFR, ERBB2
31retinoid449.8VIM, CREB1, EGFR, KRT10
32hydrocortisone44 2 59 1112.8ERBB2, MUC1, VIM
33capecitabine44 49 1111.8EGFR, ERBB2
34azathioprine44 49 2 1112.7CREB1, S100A6, VIM
35rapamycin449.7ERBB2, EGFR, CREB1, VIM
36mucicarmine449.6MUC1, PIP, VIM
37b 723449.6MUC1, PIP, VIM
38agar449.6VIM, CREB1, EGFR, MUC1, ERBB2
39dexamethasone44 49 28 1112.5ERBB2, KRT10, MUC1, CREB1, VIM
40adriamycin449.4ERBB2, MUC1, VIM
41progestin449.4VIM, S100A6, EGFR, MUC1, ERBB2
42retinoic acid44 2410.1VIM, S100A6, CREB1, EGFR, MUC1, KRT10
43tamoxifen44 49 28 1112.0VIM, PIP, EGFR, MUC1, ERBB2
44estradiol44 11 2410.9MUC1, CREB1, PIP, VIM
45serine448.9ERBB2, KRT10, MUC1, EGFR, CREB1, VIM
46steroid448.6ERBB2, KRT10, CREB1, PIP, S100A6
47paraffin448.3ERBB2, KRT10, MUC1, EGFR, PIP, S100A6
48progesterone44 59 28 11 2412.3VIM, S100A6, PIP, EGFR, MUC1, KRT10
49testosterone44 59 11 2411.3VIM, S100A6, PIP, CREB1, EGFR, MUC1

GO Terms for genes affiliated with Hidradenoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163248.6NHS, ERBB2, MUC1, PIP
2cytoplasmGO:0057377.4S100A6, CRTC1, EGFR, SH3GL1, ANXA11, MUC1

Biological processes related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription by competitive promoter bindingGO:0109449.7MUC1, CREB1
2modulation by virus of host morphology or physiologyGO:0190489.1SGTA, CREB1, CRTC1, VIM

Molecular functions related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:0047169.9ERBB2, EGFR
2epidermal growth factor-activated receptor activityGO:0050069.8ERBB2, EGFR
3S100 protein bindingGO:0445489.4ANXA11, S100A6

Products for genes affiliated with Hidradenoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hidradenoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet