MCID: HDR004
MIFTS: 48

Hidradenoma malady

Skin diseases, Endocrine diseases categories

Summaries for Hidradenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hidradenoma is a cutaneous condition, primarily occurring in adult women, that is a form of benign... more...

MalaCards: Hidradenoma, also known as hidradenoma morphology, is related to clear cell hidradenoma and syringocystadenoma papilliferum. An important gene associated with Hidradenoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are EGFR Signaling Pathway and Alpha6-Beta4 Integrin Signaling Pathway. The compounds hematoxylin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and salivary gland.

Aliases & Classifications for Hidradenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Endocrine diseases


Aliases & Descriptions:

hidradenoma 8 10 44
hidradenoma morphology 8
adenoma, sweat gland 60
sweat gland adenoma 8
hidradenoma of skin 8
syringocystadenoma 60
syringoadenoma 8


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Disease Ontology8 DOID:3896
MeSH34 D006607
NCIt39 C7560, C7563

Related Diseases for Hidradenoma

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17GeneCards, 18GeneDecks
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Diseases related to Hidradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell hidradenoma31.2SGTA
2syringocystadenoma papilliferum30.3CLEC2A, PIP
3adenocarcinoma30.2VIM, S100A6, PIP, CREB1, EGFR, MUC1
4adenoma30.0S100A6, CREB1, MUC1
5syringoma29.8MUC1
6spiradenoma29.8CLEC2A
7neurofibromatosis29.8CREB1
8hidrocystoma29.8SGTA, PIP
9ductal carcinoma in situ29.8ERBB2, EGFR
10pleomorphic adenoma29.8VIM, MUC1, ERBB2
11squamous cell carcinoma29.8VIM, S100A6, PIP, EGFR, MUC1, KRT10
12mucoepidermoid carcinoma29.8CRTC1, CREB1, EGFR, MAML2, MUC1
13breast cancer29.8AZGP1, VIM, S100A6, PIP, EGFR, MUC1
14nodular hidradenoma10.7
15papillary hidradenoma10.5
16apocrine adenoma10.4
17procarcinoma10.2
18eccrine acrospiroma10.1
19vulvar nodular hidradenoma10.1
20cystadenoma10.0
21myoepithelioma10.0
22nodular malignant melanoma10.0
23adenocarcinoma in situ10.0
24melanoma10.0
25vulva adenocarcinoma10.0
26acrospiroma10.0
27thymus cancer10.0MUC1
28papilloma10.0KRT10
29hemangioblastoma10.0MUC1
30wilms tumor10.0VIM
31angiomyolipoma10.0VIM
32cervical adenosquamous carcinoma10.0CRTC1, MAML2
33epithelial-myoepithelial carcinoma10.0MAML2, CRTC1
34alopecia10.0CLEC2A
35cervical squamous cell carcinoma10.0KRT10
36cutaneous mucoepidermoid carcinoma10.0CRTC1, MAML2
37lacrimal gland cancer10.0CRTC1, MAML2
38lipoadenoma10.0CRTC1, MAML2
39esophageal cancer10.0EGFR
40necrotizing sialometaplasia10.0CRTC1, MAML2
41acanthoma10.0CLEC2A
42fibrosarcoma10.0VIM
43clear cell ependymoma10.0MUC1, VIM
44mesenchymal chondrosarcoma10.0VIM, MUC1
45spindle cell carcinoma10.0MUC1, VIM
46neurofibroma10.0MUC1, VIM
47giant cell glioblastoma10.0EGFR
48spindle cell sarcoma10.0VIM, MUC1
49clear cell sarcoma10.0CREB1
50rhabdoid tumor10.0VIM, MUC1

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to hidradenoma

Clinical Features for Hidradenoma

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Drugs & Therapeutics for Hidradenoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hidradenoma

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Anatomical Context for Hidradenoma

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32MalaCards
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MalaCards organs/tissues related to Hidradenoma:

32
Skin, Breast, Salivary gland, Lymph node, Heart, Smooth muscle

Animal Models for Hidradenoma or affiliated genes

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Publications for Hidradenoma

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50PubMed
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Articles related to Hidradenoma:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Hidradenoma papilliferum of the orbit. (23387456)
2013
2
Malignant eccrine hidradenoma. (23878386)
2013
3
Pseudocarcinomatous hyperplasia associated with hidradenoma papilliferum. (22277786)
2012
4
A rare tumor of the face: malignant nodular hidradenoma with dermoscopic features mimicking amelanotic melanoma. (21561586)
2011
5
Giant benign nodular hidradenoma of the shoulder: A rare tumor in orthopedic practice. (21655004)
2010
6
Papillary poroid hidradenoma. (19730081)
2010
7
Two cases of hidradenoma papilliferum of the nose. (20526565)
2010
8
Giant ectopic hidradenoma papilliferum on the scalp. (19785709)
2009
9
Atypical and malignant hidradenomas: a histological and immunohistochemical study. (19252473)
2009
10
Malignant nodular hidradenoma of the skin: report of seven cases. (18410617)
2008
11
Poroid hidradenoma: a case report with review of Japanese published work. (17584332)
2007
12
Squamous cell apocrine hidradenoma. (17880588)
2007
13
'Nuclear grooves' in nodular hidradenoma: frequency and significance of an unrecognized histopatological feature. (17944729)
2007
14
Poroid hidradenoma: a case report. (18019434)
2007
15
Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. 2005;43:202-205. (16670462)
2006
16
Adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma of the peri-anal region. (17101482)
2006
17
Cytomorphological features of nodular hidradenoma highlighting eccrine differentiation: a case report. (17001903)
2006
18
Mitotic count is not predictive of clinical behavior in hidradenoma papilliferum of the vulva: a clinicopathologic study of 19 cases. (16871035)
2006
19
Clear cell hidradenoma: a mimic of metastatic clear cell tumors. (15859654)
2005
20
MRI of clear cell hidradenoma. (15648460)
2004
21
Coexpression of S-100 and smooth muscle actin in nodular hidradenoma. (12876503)
2003
22
Cystic clear cell hidradenoma of the thumb: case report of a rare hand tumor. (11862050)
2002
23
Poroid hidradenoma. (11277959)
2001
24
Malignant clear cell hidradenoma with giant metastasis to the axilla. (10917110)
2000
25
Malignant nodular hidradenoma of nose. (23119494)
1999
26
Papillary hidradenoma: immunohistochemical analysis of steroid receptor profile with a focus on apocrine differentiation. (10690173)
1999
27
S-100 protein in nodular hidradenoma. (10491053)
1999
28
Poroid hidradenoma. Report of a case with cytologic findings on fine needle aspiration. (10349383)
1999
29
Poroid hidradenoma. A case presentation. (9791957)
1998
30
Identification of aneuploidy in recurrent clear cell hidradenoma by DNA image cytometry (ICM-DNA). (9194586)
1997
31
Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression. (9027630)
1997
32
Clear cell hidradenoma simulating breast carcinoma: a diagnostic pitfall in fine-needle aspiration of breast. (8807256)
1996
33
Nodular hidradenoma of the eyelid. (8859101)
1996
34
Oncocytic nodular hidradenoma. (8806968)
1996
35
Malignant clear cell hidradenoma: a case report and literature review. (1656281)
1991
36
Mucinous syringometaplasia mimicked by a clear cell hidradenoma with mucinous change. (1662242)
1991
37
Ulcerated tumor on the scalp. Clear-cell hidradenoma. (2545168)
1989
38
Malignant clear cell hidradenoma of the lip. (2559362)
1989
39
Paget's disease, melanocytic neoplasia and hidradenoma papilliferum of the vulva. (2843453)
1988
40
Congenital papillated apocrine cystadenoma: a mixed form of hidrocystoma, hidradenoma papilliferum, and syringocystadenoma papilliferum. (6090513)
1984
41
Combined papillary syringocystadenoma and hidradenoma. A case study. (198458)
1977
42
Clear cell hidradenoma of the breast. (4298177)
1968
43
Clear cell hidradenoma. Histological, histochemical, and electron microscopic studies. (4291187)
1967
44
Histochemistry of hidradenoma and eccrine spiradenoma. (4292174)
1967
45
Hidradenoma of the vulva in pregnancy with recurrence after local excision. (4293794)
1967
46
CLEAR CELL HIDRADENOMA OR MYOEPITHELIOMA OF THE EYELID. (14149750)
1964
47
A nodular hidradenoma of unusual histological type. (14022861)
1962
48
Hidradenoma of the vulva. (14418420)
1960
49
Clear-cell hidradenoma. (13588473)
1958
50
Hidradenoma of the perianum. (13197686)
1954

Genetic Variations for Hidradenoma

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Expression for genes affiliated with Hidradenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hidradenoma

Search GEO for disease gene expression data for Hidradenoma.

Pathways for genes affiliated with Hidradenoma

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55SinoBiological, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Hidradenoma

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Hidradenoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1hematoxylin4410.4KRT10, VIM
2s 1004410.4VIM, MUC1
3Afatinib1110.3EGFR, ERBB2
4jnj 28871063 hydrochloride5910.3EGFR, ERBB2
5ag 4905910.3EGFR, ERBB2
6ag 1478 hydrochloride5910.3EGFR, ERBB2
7iressa5910.3EGFR, ERBB2
8pd1587804410.3EGFR, ERBB2
9pertuzumab44 49 1112.3EGFR, ERBB2
10pki-1664410.3EGFR, ERBB2
11hrgbeta14410.3EGFR, ERBB2
12eosin4410.3KRT10, MUC1, VIM
13quinazoline4410.3EGFR, ERBB2
14erbstatin4410.2EGFR, ERBB2
15everolimus49 44 1112.1EGFR, ERBB2
16reticulin4410.1VIM, MUC1
17pd1530354410.1EGFR, KRT10, ERBB2
18trastuzumab44 49 1112.1EGFR, MUC1, ERBB2
19ganciclovir44 1111.1ERBB2, CREB1, VIM
20anastrozole44 1111.0EGFR, ERBB2
214-hydroxytamoxifen4410.0ERBB2, EGFR, VIM
22gemcitabine44 49 1112.0EGFR, MUC1, ERBB2
23biotin44 11 2412.0ERBB2, MUC1, VIM
24gefitinib44 49 1112.0ERBB2, EGFR, VIM
25ag 14784410.0ERBB2, EGFR, CREB1
26bexarotene44 28 1112.0EGFR, KRT10
27polyethylene glycol449.9AZGP1, MUC1, ERBB2
28gf 109203x44 5910.9CREB1, EGFR, KRT10
29chloramphenicol44 2 1111.9ERBB2, MUC1, CREB1, VIM
30thymidylate449.9VIM, EGFR, ERBB2
31retinoid449.8VIM, CREB1, EGFR, KRT10
32hydrocortisone44 2 59 1112.8ERBB2, MUC1, VIM
33capecitabine44 49 1111.8EGFR, ERBB2
34azathioprine44 49 2 1112.7CREB1, S100A6, VIM
35rapamycin449.7ERBB2, EGFR, CREB1, VIM
36mucicarmine449.6MUC1, PIP, VIM
37b 723449.6MUC1, PIP, VIM
38agar449.6VIM, CREB1, EGFR, MUC1, ERBB2
39dexamethasone44 49 28 1112.5ERBB2, KRT10, MUC1, CREB1, VIM
40adriamycin449.4ERBB2, MUC1, VIM
41progestin449.4VIM, S100A6, EGFR, MUC1, ERBB2
42retinoic acid44 2410.1VIM, S100A6, CREB1, EGFR, MUC1, KRT10
43tamoxifen44 49 28 1112.0VIM, PIP, EGFR, MUC1, ERBB2
44estradiol44 11 2410.9MUC1, CREB1, PIP, VIM
45serine448.9ERBB2, KRT10, MUC1, EGFR, CREB1, VIM
46steroid448.6ERBB2, KRT10, CREB1, PIP, S100A6
47paraffin448.3ERBB2, KRT10, MUC1, EGFR, PIP, S100A6
48progesterone44 59 28 11 2412.3VIM, S100A6, PIP, EGFR, MUC1, KRT10
49testosterone44 59 11 2411.3VIM, S100A6, PIP, CREB1, EGFR, MUC1

GO Terms for genes affiliated with Hidradenoma

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16Gene Ontology
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Cellular components related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163248.6NHS, ERBB2, MUC1, PIP
2cytoplasmGO:0057377.4S100A6, CRTC1, EGFR, SH3GL1, ANXA11, MUC1

Biological processes related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription by competitive promoter bindingGO:0109449.7MUC1, CREB1
2modulation by virus of host morphology or physiologyGO:0190489.1SGTA, CREB1, CRTC1, VIM

Molecular functions related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:0047169.9ERBB2, EGFR
2epidermal growth factor-activated receptor activityGO:0050069.8ERBB2, EGFR
3S100 protein bindingGO:0445489.4ANXA11, S100A6

Products for genes affiliated with Hidradenoma

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  • Antibodies
  • Proteins
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Sources for Hidradenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet