MCID: HDR004
MIFTS: 48

Hidradenoma malady

Skin diseases, Endocrine diseases categories

Summaries for Hidradenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hidradenoma is a cutaneous condition, primarily occurring in adult women, that is a form of benign... more...

MalaCards: Hidradenoma, also known as hidradenoma morphology, is related to clear cell hidradenoma and syringocystadenoma papilliferum. An important gene associated with Hidradenoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are EGFR Signaling Pathway and Alpha6-Beta4 Integrin Signaling Pathway. The compounds hematoxylin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and salivary gland.

Aliases & Classifications for Hidradenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Endocrine diseases


Aliases & Descriptions:

hidradenoma 8 10 44
hidradenoma morphology 8
adenoma, sweat gland 60
sweat gland adenoma 8
hidradenoma of skin 8
syringocystadenoma 60
syringoadenoma 8


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Disease Ontology8 DOID:3896
MeSH34 D006607
NCIt39 C7560, C7563

Related Diseases for Hidradenoma

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17GeneCards, 18GeneDecks
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Diseases related to Hidradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell hidradenoma31.2SGTA
2syringocystadenoma papilliferum30.3CLEC2A, PIP
3adenocarcinoma30.2VIM, S100A6, PIP, CREB1, EGFR, MUC1
4adenoma30.0S100A6, CREB1, MUC1
5syringoma29.8MUC1
6spiradenoma29.8CLEC2A
7neurofibromatosis29.8CREB1
8hidrocystoma29.8SGTA, PIP
9ductal carcinoma in situ29.8ERBB2, EGFR
10pleomorphic adenoma29.8VIM, MUC1, ERBB2
11squamous cell carcinoma29.8VIM, S100A6, PIP, EGFR, MUC1, KRT10
12mucoepidermoid carcinoma29.8CRTC1, CREB1, EGFR, MAML2, MUC1
13breast cancer29.8AZGP1, VIM, S100A6, PIP, EGFR, MUC1
14nodular hidradenoma10.7
15papillary hidradenoma10.5
16apocrine adenoma10.4
17procarcinoma10.2
18eccrine acrospiroma10.1
19vulvar nodular hidradenoma10.1
20cystadenoma10.0
21myoepithelioma10.0
22nodular malignant melanoma10.0
23adenocarcinoma in situ10.0
24melanoma10.0
25vulva adenocarcinoma10.0
26acrospiroma10.0
27thymus cancer10.0MUC1
28papilloma10.0KRT10
29hemangioblastoma10.0MUC1
30wilms tumor10.0VIM
31angiomyolipoma10.0VIM
32cervical adenosquamous carcinoma10.0CRTC1, MAML2
33epithelial-myoepithelial carcinoma10.0MAML2, CRTC1
34alopecia10.0CLEC2A
35cervical squamous cell carcinoma10.0KRT10
36cutaneous mucoepidermoid carcinoma10.0CRTC1, MAML2
37lacrimal gland cancer10.0CRTC1, MAML2
38lipoadenoma10.0CRTC1, MAML2
39esophageal cancer10.0EGFR
40necrotizing sialometaplasia10.0CRTC1, MAML2
41acanthoma10.0CLEC2A
42fibrosarcoma10.0VIM
43clear cell ependymoma10.0MUC1, VIM
44mesenchymal chondrosarcoma10.0VIM, MUC1
45spindle cell carcinoma10.0MUC1, VIM
46neurofibroma10.0MUC1, VIM
47giant cell glioblastoma10.0EGFR
48spindle cell sarcoma10.0VIM, MUC1
49clear cell sarcoma10.0CREB1
50rhabdoid tumor10.0VIM, MUC1

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to hidradenoma

Clinical Features for Hidradenoma

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Drugs & Therapeutics for Hidradenoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hidradenoma

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Anatomical Context for Hidradenoma

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32MalaCards
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MalaCards organs/tissues related to Hidradenoma:

32
Skin, Breast, Salivary gland, Lymph node, Heart, Smooth muscle

Animal Models for Hidradenoma or affiliated genes

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Publications for Hidradenoma

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50PubMed
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Articles related to Hidradenoma:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Ectopic hidradenoma papilliferum dermoscopically mimicking a blue nevus: a case report and review of the literature. (23557245)
2014
2
Nodular Hidradenoma of the Caruncle. (23715517)
2013
3
Clear cell nodular hidradenoma involving the lymphatic system: a tumor of uncertain malignant potential or a novel example of "metastasizing" benign tumor? (23095508)
2012
4
Benign nodular hidradenoma of the face. (21415656)
2011
5
Malignant nodular hidradenoma treated with Mohs micrographic surgery. (22106723)
2011
6
Hidradenoma papilliferum of the vulva: case report and review of literature. (21132312)
2011
7
Nodular hidradenoma in a 19-year-old woman. (22393689)
2011
8
Poroid hidradenoma in a child: an unusual presentation. (21276058)
2011
9
Nodular hidradenoma of male breast: Cytohistological correlation. (22090707)
2011
10
Clear cell hidradenoma of the axilla: a case report with literature review. (20592936)
2010
11
Epidermal growth factor receptor gene status by fluorescence in situ hybridization in malignant, atypical, and benign hidradenomas. (20534988)
2010
12
Nodular hidradenoma of the breast: A case report with literature review. (23133109)
2009
13
Origin of poroid hidradenoma and pigmentation mechanism of eccrine poroma: critical analysis of an unique presentation. (18783473)
2009
14
Solitary nodule over the labia majora. Hidradenoma papilliferum. (19439903)
2009
15
Clear cell hidradenoma: an unusual vulvar tumor. (18580328)
2008
16
A single lesion showing features of pigmented eccrine poroma and poroid hidradenoma. (18422687)
2008
17
POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands. (18338330)
2008
18
Malignant nodular hidradenoma with angiolymphatic invasion: a case report. (17883130)
2007
19
Benign hidradenoma: magnetic resonance and ultrasound features of two cases. (17624528)
2007
20
Nodular hidradenoma of the lower eyelid. (17361265)
2007
21
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands. (15268713)
2004
22
Ectopic hidradenoma papilliferum: a case report and literature review. (12652207)
2003
23
Malignant clear-cell hidradenoma associated with pseudoepitheliomatous hyperplasia on the forehead. (12671396)
2003
24
Large ulcerated perianal hidradenoma papilliferum in a young female. (12828711)
2003
25
Mixed tubulopapillary hidradenoma and syringocystadenoma papilliferum occurring as a verrucous tumor. (12641782)
2003
26
Extramammary Paget disease with underlying hidradenoma papilliferum: guilt by association? (11048981)
2000
27
Ectopic hidradenoma papilliferum: a case report and review of the literature. (10411423)
1999
28
Tubulopapillary hidradenoma-like tumor of the mandible: clinicopathologic and immunohistochemical features. (9574952)
1998
29
Perianal hidradenoma papilliferum occurring in a male: a case report. (9540295)
1998
30
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. (9788267)
1998
31
Phenotypic heterogeneity of nodular hidradenoma. Immunohistochemical analysis with emphasis on cytokeratin expression. (8989931)
1996
32
Fine-needle aspiration diagnosis of a vulvar papillary hidradenoma: a case report. (8005045)
1994
33
Cytogenetic heterogeneity in a clear cell hidradenoma of the skin. (7923079)
1994
34
Recurrent draining cyst on the shoulder. Clear cell hidradenoma (CCH) (nodular hidradenoma). (1332631)
1992
35
Malignant hidradenoma--a case report demonstrating insidious histological and clinical progression. (1666865)
1991
36
Hidradenoma papilliferum of the upper eyelid arising from the apocrine gland of Moll. (1965020)
1990
37
Eruptive hidradenoma. (2166651)
1990
38
Malignant clear-cell hidradenoma. (3037576)
1987
39
Papillary eccrine adenoma. A tubulopapillary hidradenoma with eccrine differentiation. (3518523)
1986
40
Epidermoid hidradenoma. A clinicopathologic study. (6292273)
1982
41
Identification of papillary hidradenoma of the vulva by imprint cytology. (6254297)
1980
42
Diagnosis of a papillary hidradenoma of the vulva by simultaneous cytology and colposcopy. (219648)
1979
43
Atypical hidradenoma arising in a dermoid cyst of the spinal canal. (175142)
1975
44
Syringeal hidradenoma--an unusual eccrine tumour. (4109429)
1971
45
Paget's disease of the vulva associated with adenocarcinoma developing in a hidradenoma papilliferum. (4290333)
1967
46
Hidradenoma papilliferum. (4286191)
1966
47
HIDRADENOMA OF THE ANAL CANAL. (14280233)
1965
48
Hidradenoma of the anus. (13322296)
1956
49
Hidradenoma of the anus. (14361893)
1955
50
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952

Genetic Variations for Hidradenoma

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Expression for genes affiliated with Hidradenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hidradenoma

Search GEO for disease gene expression data for Hidradenoma.

Pathways for genes affiliated with Hidradenoma

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55SinoBiological, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Hidradenoma

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Hidradenoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1hematoxylin4410.4KRT10, VIM
2s 1004410.4VIM, MUC1
3Afatinib1110.3EGFR, ERBB2
4jnj 28871063 hydrochloride5910.3EGFR, ERBB2
5ag 4905910.3EGFR, ERBB2
6ag 1478 hydrochloride5910.3EGFR, ERBB2
7iressa5910.3EGFR, ERBB2
8pd1587804410.3EGFR, ERBB2
9pertuzumab44 49 1112.3EGFR, ERBB2
10pki-1664410.3EGFR, ERBB2
11hrgbeta14410.3EGFR, ERBB2
12eosin4410.3KRT10, MUC1, VIM
13quinazoline4410.3EGFR, ERBB2
14erbstatin4410.2EGFR, ERBB2
15everolimus49 44 1112.1EGFR, ERBB2
16reticulin4410.1VIM, MUC1
17pd1530354410.1EGFR, KRT10, ERBB2
18trastuzumab44 49 1112.1EGFR, MUC1, ERBB2
19ganciclovir44 1111.1ERBB2, CREB1, VIM
20anastrozole44 1111.0EGFR, ERBB2
214-hydroxytamoxifen4410.0ERBB2, EGFR, VIM
22gemcitabine44 49 1112.0EGFR, MUC1, ERBB2
23biotin44 11 2412.0ERBB2, MUC1, VIM
24gefitinib44 49 1112.0ERBB2, EGFR, VIM
25ag 14784410.0ERBB2, EGFR, CREB1
26bexarotene44 28 1112.0EGFR, KRT10
27polyethylene glycol449.9AZGP1, MUC1, ERBB2
28gf 109203x44 5910.9CREB1, EGFR, KRT10
29chloramphenicol44 2 1111.9ERBB2, MUC1, CREB1, VIM
30thymidylate449.9VIM, EGFR, ERBB2
31retinoid449.8VIM, CREB1, EGFR, KRT10
32hydrocortisone44 2 59 1112.8ERBB2, MUC1, VIM
33capecitabine44 49 1111.8EGFR, ERBB2
34azathioprine44 49 2 1112.7CREB1, S100A6, VIM
35rapamycin449.7ERBB2, EGFR, CREB1, VIM
36mucicarmine449.6MUC1, PIP, VIM
37b 723449.6MUC1, PIP, VIM
38agar449.6VIM, CREB1, EGFR, MUC1, ERBB2
39dexamethasone44 49 28 1112.5ERBB2, KRT10, MUC1, CREB1, VIM
40adriamycin449.4ERBB2, MUC1, VIM
41progestin449.4VIM, S100A6, EGFR, MUC1, ERBB2
42retinoic acid44 2410.1VIM, S100A6, CREB1, EGFR, MUC1, KRT10
43tamoxifen44 49 28 1112.0VIM, PIP, EGFR, MUC1, ERBB2
44estradiol44 11 2410.9MUC1, CREB1, PIP, VIM
45serine448.9ERBB2, KRT10, MUC1, EGFR, CREB1, VIM
46steroid448.6ERBB2, KRT10, CREB1, PIP, S100A6
47paraffin448.3ERBB2, KRT10, MUC1, EGFR, PIP, S100A6
48progesterone44 59 28 11 2412.3VIM, S100A6, PIP, EGFR, MUC1, KRT10
49testosterone44 59 11 2411.3VIM, S100A6, PIP, CREB1, EGFR, MUC1

GO Terms for genes affiliated with Hidradenoma

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16Gene Ontology
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Cellular components related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163248.6NHS, ERBB2, MUC1, PIP
2cytoplasmGO:0057377.4S100A6, CRTC1, EGFR, SH3GL1, ANXA11, MUC1

Biological processes related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription by competitive promoter bindingGO:0109449.7MUC1, CREB1
2modulation by virus of host morphology or physiologyGO:0190489.1SGTA, CREB1, CRTC1, VIM

Molecular functions related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:0047169.9ERBB2, EGFR
2epidermal growth factor-activated receptor activityGO:0050069.8ERBB2, EGFR
3S100 protein bindingGO:0445489.4ANXA11, S100A6

Products for genes affiliated with Hidradenoma

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Sources for Hidradenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet