MCID: HDR004
MIFTS: 54

Hidradenoma malady

Cancer diseases, Skin diseases, Endocrine diseases categories
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Summaries for Hidradenoma

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Wikipedia:65 Hidradenoma(also known as acrospiroma, from akral \"peripheral\" + spiroma \"epithelial tumor of sweat... more...

MalaCards based summary: Hidradenoma, also known as hidradenoma morphology, is related to clear cell hidradenoma and syringocystadenoma papilliferum. An important gene associated with Hidradenoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are SHC1 events in ERBB2 signaling and Alzheimers Disease Pathway. The compounds ag 1478 and eosin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and salivary gland, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Hidradenoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 39NCIt, 57SNOMED-CT
See all sources

Hidradenoma, Aliases & Descriptions:

Name: Hidradenoma 8 10 44
Hidradenoma Morphology 8
Adenoma, Sweat Gland 62
Sweat Gland Adenoma 8
 
Hidradenoma of Skin 8
Syringocystadenoma 62
Syringoadenoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Endocrine diseases


External Ids:

Disease Ontology8 DOID:3896
MeSH34 D006607
NCIt39 C7560, C7563

Related Diseases for Hidradenoma

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Diseases related to Hidradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell hidradenoma32.1SGTA
2syringocystadenoma papilliferum30.9PIP, CLEC2A
3syringoma30.7MUC1
4mucoepidermoid carcinoma30.4CRTC1, MAML2
5hidrocystoma30.4PIP, SGTA
6adenosquamous carcinoma30.4MUC1, EGFR
7ductal carcinoma in situ30.0EGFR, ERBB2
8pleomorphic adenoma30.0ERBB2, VIM, MUC1
9breast cancer29.7PIP, ERBB2, EGFR
10adenocarcinoma29.3EGFR, PIP, VIM, CREB1, MUC1, ERBB2
11nodular hidradenoma10.8
12papillary hidradenoma10.5
13cystadenocarcinoma10.5MUC1
14adenomatoid tumor10.5VIM
15paraganglioma10.5VIM
16hidradenocarcinoma10.4
17giant cell glioblastoma10.4EGFR
18fibrous histiocytoma10.4CREB1
19cervical adenosquamous carcinoma10.4MAML2, CRTC1
20lacrimal gland cancer10.4CRTC1, MAML2
21cutaneous mucoepidermoid carcinoma10.4MAML2, CRTC1
22lipoadenoma10.4CRTC1, MAML2
23necrotizing sialometaplasia10.4CRTC1, MAML2
24clear cell ependymoma10.4MUC1, VIM
25epithelial-myoepithelial carcinoma10.4CRTC1, MAML2
26mesenchymal chondrosarcoma10.4VIM, MUC1
27spindle cell carcinoma10.4VIM, MUC1
28spindle cell sarcoma10.4VIM, MUC1
29epithelioid sarcoma10.3MUC1, VIM
30sertoli cell tumor10.3MUC1, VIM
31dermatofibrosarcoma protuberans10.3MUC1, VIM
32secretory meningioma10.3VIM, MUC1
33rhabdoid tumor10.3VIM, MUC1
34perineurioma10.3VIM, MUC1
35hemangiopericytoma10.3VIM, MUC1
36sex cord-gonadal stromal tumor10.3VIM, MUC1
37chordoma10.3VIM, MUC1
38angiosarcoma10.3MUC1, VIM
39abrikosov's tumor10.3VIM, MUC1
40giant cell tumor10.3VIM, MUC1
41neurofibroma10.3MUC1, VIM
42malignant fibroxanthoma10.3VIM, MUC1
43eccrine acrospiroma10.3
44oxyphilic adenoma10.3MUC1, VIM
45synovial sarcoma10.2MUC1, VIM
46renal clear cell carcinoma10.2VIM, MUC1
47malignant peripheral nerve sheath tumor10.2EGFR, VIM
48vulvar nodular hidradenoma10.2
49leiomyosarcoma10.2MUC1, VIM
50mammary paget's disease10.2ERBB2, MUC1

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to hidradenoma

Symptoms for Hidradenoma

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Drugs & Therapeutics for Hidradenoma

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Drug clinical trials:

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Search NIH Clinical Center for Hidradenoma

Genetic Tests for Hidradenoma

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Anatomical Context for Hidradenoma

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MalaCards organs/tissues related to Hidradenoma:

32
Skin, Breast, Salivary gland, Lymph node, Heart, Smooth muscle

Animal Models for Hidradenoma or affiliated genes

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MGI Mouse Phenotypes related to Hidradenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1EGFR, ERBB2, CRTC1, CREB1, MUC1, VIM
2MP:00053797.9EGFR, ERBB2, CRTC1, CREB1, MUC1, PIP
3MP:00053897.8PIP, VIM, CREB1, CRTC1, ERBB2, EGFR
4MP:00053857.6PIP, VIM, CREB1, CRTC1, ERBB2, EGFR

Publications for Hidradenoma

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Articles related to Hidradenoma:

(show top 50)    (show all 249)
idTitleAuthorsYear
1
Nodular hidradenoma of the scalp: A cytomorphological evaluation on fine needle aspiration cytology. (25382530)
2014
2
A case of tubulopapillary hidradenoma on the face. (25269926)
2014
3
Giant eccrine hidradenoma mimicking a malignant tumor of the salivary gland. (25075376)
2014
4
Hidradenoma papilliferum, diagnostic challenge: a case. (25387849)
2014
5
Malignant nodular hidradenoma of scalp. (25288856)
2014
6
Hidradenoma papilliferum of the orbit. (23387456)
2013
7
Nodular Hidradenoma of the Caruncle. (23715517)
2013
8
Benign hidradenoma masquerading as ductal breast cancer-a rare case of false-positive recurrence in cancer follow-up. (24102904)
2013
9
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
10
Hidradenoma papilliferum presenting as an eyelid mass. (22820442)
2012
11
Benign nodular hidradenoma of the face. (21415656)
2011
12
Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report. (21053567)
2010
13
From hidroacanthoma simplex to poroid hidradenoma: clinicopathologic and immunohistochemic study of poroid neoplasms and reappraisal of their histogenesis. (20571345)
2010
14
Fine-needle aspiration cytology of apocrine hidradenoma. (20698151)
2010
15
Clear cell hidradenoma of the axilla: a case report with literature review. (20592936)
2010
16
Giant benign nodular hidradenoma of the shoulder: A rare tumor in orthopedic practice. (21655004)
2010
17
Clear cell hidradenoma of the gluteal region: a case report. (19595274)
2009
18
Nodular hidradenoma of the breast: A case report with literature review. (23133109)
2009
19
Giant ectopic hidradenoma papilliferum on the scalp. (19785709)
2009
20
Dermoscopic features of clear cell hidradenoma. (18663309)
2008
21
Poroid hidradenoma: a case report with review of Japanese published work. (17584332)
2007
22
Clear cell hidradenoma of the ankle. (17761324)
2007
23
Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. 2005;43:202-205. (16670462)
2006
24
Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion. (15729701)
2005
25
Asymptomatic slowly enlarging nodule on the trunk: eccrine hidradenoma. (15009319)
2004
26
Vulvar poroid hidradenoma. (12454609)
2002
27
Malignant nodular hidradenoma in a patient with neurofibromatosis type 1: a case report and review of the literature. (11710446)
2001
28
Extramammary Paget disease with underlying hidradenoma papilliferum: guilt by association? (11048981)
2000
29
Vulvar hidradenoma papilliferum. A review of 10.5 years' experience. (10986678)
2000
30
Malignant nodular hidradenoma of nose. (23119494)
1999
31
Ectopic hidradenoma papilliferum: a case report and review of the literature. (10411423)
1999
32
Fine needle aspiration cytology of poroid hidradenoma. (9684613)
1998
33
Clear cell hidradenoma simulating breast carcinoma: a diagnostic pitfall in fine-needle aspiration of breast. (8807256)
1996
34
Fine-needle aspiration diagnosis of a vulvar papillary hidradenoma: a case report. (8005045)
1994
35
Cytogenetic heterogeneity in a clear cell hidradenoma of the skin. (7923079)
1994
36
Clear cell hidradenoma: a tumor with basaliomatous changes in the overlying epidermis and follicular infundibula of surrounding skin. (1328338)
1992
37
Eccrine acrospiroma (clear cell hidradenoma) of the eyelid. Immunohistochemical and ultrastructural features. (1708858)
1991
38
Malignant hidradenoma--a case report demonstrating insidious histological and clinical progression. (1666865)
1991
39
Clear cell hidradenoma. A case report. (2176689)
1990
40
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. (2984259)
1985
41
Combined papillary syringocystadenoma and hidradenoma. A case study. (198458)
1977
42
Syringeal hidradenoma--an unusual eccrine tumour. (4109429)
1971
43
Clear cell hidradenoma of the eyelid. (4298541)
1968
44
HIDRADENOMA OF THE ANAL CANAL. (14280233)
1965
45
A nodular hidradenoma of unusual histological type. (14022861)
1962
46
Clear-cell hidradenoma. (13588473)
1958
47
Hidradenoma of the vulva. (14933503)
1952
48
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952
49
Hidradenoma of the vulva. (14782694)
1950
50
Hidradenoma of the vulva. (18106314)
1948

Variations for Hidradenoma

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Expression for genes affiliated with Hidradenoma

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Expression patterns in normal tissues for genes affiliated with Hidradenoma

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Pathways for genes affiliated with Hidradenoma

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Pathways related to Hidradenoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7EGFR, ERBB2
29.7EGFR, ERBB2
39.7EGFR, ERBB2
49.7ERBB2, EGFR
5
Show member pathways
9.7MAML2, CREB1
69.4EGFR, ERBB2, MUC1
7
Show member pathways
9.4EGFR, VIM, ERBB2
89.4EGFR, ERBB2, VIM
9
Show member pathways
9.3CREB1, ERBB2, EGFR
10
Show member pathways
9.3EGFR, CREB1, ERBB2
11
Show member pathways
Signaling Pathways in Glioblastoma37
9.3CREB1, ERBB2, EGFR
12
Show member pathways
9.3CREB1, ERBB2, EGFR
13
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.3CREB1, EGFR, ERBB2
14
Show member pathways
9.3EGFR, ERBB2, CREB1
15
Show member pathways
9.3ERBB2, CREB1, EGFR
169.3ERBB2, CREB1, EGFR
17
Show member pathways
9.3EGFR, ERBB2, CREB1
18
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3ERBB2, EGFR, CREB1
19
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.0EGFR, ERBB2, MUC1, CREB1
208.9MAML2, EGFR, CREB1, ERBB2
21
Show member pathways
8.8PIP, EGFR, ERBB2, CREB1
22
Show member pathways
8.8ERBB2, PIP, EGFR, CREB1
23
Show member pathways
8.2PIP, VIM, EGFR, ERBB2, CREB1, MUC1

Compounds for genes affiliated with Hidradenoma

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Compounds related to Hidradenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1ag 14784410.5CREB1
2eosin4410.2MUC1, VIM
3s 1004410.2MUC1, VIM
4pd1587804410.1EGFR, ERBB2
5jnj 28871063 hydrochloride6110.1EGFR, ERBB2
6afatinib50 1111.1EGFR, ERBB2
7ag 1478 hydrochloride6110.1ERBB2, EGFR
8ag 4906110.1EGFR, ERBB2
9iressa6110.1ERBB2, EGFR
10pertuzumab44 50 1112.1ERBB2, EGFR
11pki-1664410.0ERBB2, EGFR
12hrgbeta14410.0EGFR, ERBB2
13quinazoline4410.0ERBB2, EGFR
14reticulin4410.0MUC1, VIM
15erbstatin449.9ERBB2, EGFR
16ganciclovir44 1110.9ERBB2, VIM, CREB1
17trastuzumab44 50 1111.8ERBB2, MUC1, EGFR
18biotin44 24 1111.8VIM, ERBB2, MUC1
19hydrocortisone44 2 61 1112.8MUC1, VIM, ERBB2
20mucicarmine449.8MUC1, VIM, PIP
21adriamycin449.8ERBB2, MUC1, VIM
22b 723449.8MUC1, VIM, PIP
234-hydroxytamoxifen449.8EGFR, VIM, ERBB2
24capecitabine44 50 1111.8ERBB2, EGFR
25gemcitabine44 50 1111.8EGFR, MUC1, ERBB2
26gefitinib44 50 1111.7EGFR, VIM, ERBB2
27anastrozole44 50 1111.7EGFR, ERBB2
28pd153035449.7ERBB2, EGFR
29thymidylate449.7EGFR, ERBB2, VIM
30formaldehyde44 2410.7ERBB2, MUC1, VIM
31dihydrotestosterone44 28 24 1112.6PIP, VIM, MUC1
32folate449.6VIM, MUC1, ERBB2
33exemestane44 50 61 1112.6ERBB2, EGFR
34herbimycin a44 6110.6EGFR, CREB1, ERBB2
35chloramphenicol44 2 50 1112.6VIM, MUC1, ERBB2, CREB1
36curcumin449.5CREB1, EGFR, ERBB2
37progestin449.5ERBB2, MUC1, EGFR, VIM
38rapamycin449.4EGFR, CREB1, VIM, ERBB2
39genistein44 28 61 2 24 1114.4VIM, CREB1, ERBB2, EGFR
40everolimus44 50 1111.4ERBB2, EGFR
41estradiol44 24 1111.4PIP, VIM, MUC1, CREB1
42cycloheximide449.3VIM, EGFR, ERBB2, CREB1
43agar449.2VIM, EGFR, ERBB2, MUC1, CREB1
44cyclic amp44 2410.2CREB1, MUC1, VIM, CRTC1
45vegf449.2MUC1, ERBB2, EGFR, VIM, CREB1
46tamoxifen44 50 28 1112.0VIM, EGFR, ERBB2, MUC1, PIP
47paraffin449.0PIP, ERBB2, EGFR, MUC1, VIM
48progesterone44 28 61 24 1113.0PIP, MUC1, VIM, ERBB2, EGFR
49testosterone44 61 24 1111.7VIM, MUC1, CREB1, ERBB2, EGFR, PIP
50estrogen448.6VIM, EGFR, PIP, ERBB2, CREB1, MUC1

GO Terms for genes affiliated with Hidradenoma

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Cellular components related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163248.9EGFR, ERBB2, MUC1, PIP

Biological processes related to Hidradenoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription by competitive promoter bindingGO:01094410.1CREB1, MUC1
2positive regulation of MAP kinase activityGO:0434069.7ERBB2, EGFR
3positive regulation of epithelial cell proliferationGO:0506799.7EGFR, ERBB2
4phosphatidylinositol-mediated signalingGO:0480159.6EGFR, ERBB2, CREB1
5fibroblast growth factor receptor signaling pathwayGO:0085439.5EGFR, ERBB2, CREB1
6Fc-epsilon receptor signaling pathwayGO:0380959.5EGFR, ERBB2, CREB1
7epidermal growth factor receptor signaling pathwayGO:0071739.5CREB1, ERBB2, EGFR
8activation of phospholipase C activityGO:0072029.4EGFR, CREB1
9neurotrophin TRK receptor signaling pathwayGO:0480119.4EGFR, ERBB2, CREB1
10axon guidanceGO:0074119.2EGFR, ERBB2, CREB1
11viral processGO:0160328.9SGTA, VIM, CREB1, CRTC1
12positive regulation of transcription from RNA polymerase II promoterGO:0459448.8EGFR, CRTC1, CREB1, MAML2

Molecular functions related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription cofactor activityGO:0037129.8CREB1, MUC1
2epidermal growth factor-activated receptor activityGO:0050069.8EGFR, ERBB2
3receptor signaling protein tyrosine kinase activityGO:0047169.7ERBB2, EGFR
4transmembrane receptor protein tyrosine kinase activityGO:0047149.4EGFR, ERBB2
5glycoprotein bindingGO:0019489.3EGFR, VIM, PIP
6protein bindingGO:0055156.7SGTA, CLEC2A, VIM, MUC1, CREB1, CRTC1

Products for genes affiliated with Hidradenoma

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Sources for Hidradenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet