MCID: HDR004
MIFTS: 54

Hidradenoma malady

Cancer diseases, Skin diseases, Endocrine diseases categories
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Summaries for Hidradenoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Hidradenoma is a cutaneous condition, primarily occurring in adult women, that is a form of benign... more...

MalaCards: Hidradenoma, also known as hidradenoma morphology, is related to clear cell hidradenoma and syringocystadenoma papilliferum. An important gene associated with Hidradenoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are Alzheimers Disease Pathway and SHC1 events in ERBB2 signaling. The compounds ag 1478 and eosin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and salivary gland, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Hidradenoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Endocrine diseases


Aliases & Descriptions:

hidradenoma 8 10 45
hidradenoma morphology 8
adenoma, sweat gland 62
sweat gland adenoma 8
hidradenoma of skin 8
syringocystadenoma 62
syringoadenoma 8


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Disease Ontology8 DOID:3896
MeSH35 D006607
NCIt40 C7563, C7560

Related Diseases for Hidradenoma

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17GeneCards, 18GeneDecks
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Diseases related to Hidradenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell hidradenoma31.5SGTA
2syringocystadenoma papilliferum30.5CLEC2A, PIP
3syringoma30.1MUC1
4glomus tumor30.1VIM
5mucoepidermoid carcinoma30.0CRTC1, MAML2
6adenocarcinoma30.0PIP, VIM, MUC1, CREB1, ERBB2, EGFR
7hidrocystoma30.0PIP, SGTA
8adenosquamous carcinoma30.0MUC1, EGFR
9ductal carcinoma in situ29.9EGFR, ERBB2
10pleomorphic adenoma29.9ERBB2, MUC1, VIM
11breast cancer29.9EGFR, ERBB2, PIP
12nodular hidradenoma10.8
13papillary hidradenoma10.5
14hidradenocarcinoma10.4
15eccrine acrospiroma10.2
16vulvar nodular hidradenoma10.2
17acrospiroma10.2
18cystadenocarcinoma10.1MUC1
19adenomatoid tumor10.1VIM
20myoepithelioma10.1
21cystadenoma10.1
22adenoma10.1
23melanoma10.1
24giant cell glioblastoma10.1EGFR
25fibrous histiocytoma10.1CREB1
26cervical adenosquamous carcinoma10.1MAML2, CRTC1
27lacrimal gland cancer10.1MAML2, CRTC1
28cutaneous mucoepidermoid carcinoma10.1CRTC1, MAML2
29lipoadenoma10.1CRTC1, MAML2
30necrotizing sialometaplasia10.1CRTC1, MAML2
31clear cell ependymoma10.1VIM, MUC1
32epithelial-myoepithelial carcinoma10.1MAML2, CRTC1
33mesenchymal chondrosarcoma10.1MUC1, VIM
34spindle cell carcinoma10.1VIM, MUC1
35spindle cell sarcoma10.1VIM, MUC1
36epithelioid sarcoma10.1VIM, MUC1
37sertoli cell tumor10.1VIM, MUC1
38dermatofibrosarcoma protuberans10.1VIM, MUC1
39secretory meningioma10.1VIM, MUC1
40rhabdoid tumor10.1VIM, MUC1
41perineurioma10.1VIM, MUC1
42hemangiopericytoma10.1VIM, MUC1
43sex cord-gonadal stromal tumor10.1VIM, MUC1
44chordoma10.1MUC1, VIM
45angiosarcoma10.1VIM, MUC1
46malignant peripheral nerve sheath tumor10.1VIM, MUC1
47abrikosov's tumor10.1VIM, MUC1
48giant cell tumor10.1VIM, MUC1
49malignant fibroxanthoma10.1MUC1, VIM
50neurofibroma10.1MUC1, VIM

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to hidradenoma

Symptoms for Hidradenoma

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Drugs & Therapeutics for Hidradenoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Hidradenoma

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Anatomical Context for Hidradenoma

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33MalaCards
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MalaCards organs/tissues related to Hidradenoma:

33
Skin, Breast, Salivary gland, Lymph node, Heart, Smooth muscle

Animal Models for Hidradenoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hidradenoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1EGFR, ERBB2, CRTC1, CREB1, MUC1, VIM
2MP:00053797.9EGFR, ERBB2, CRTC1, CREB1, MUC1, PIP
3MP:00053897.8PIP, VIM, CREB1, CRTC1, ERBB2, EGFR
4MP:00053857.6PIP, VIM, CREB1, CRTC1, ERBB2, EGFR

Publications for Hidradenoma

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52PubMed
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Articles related to Hidradenoma:

(show top 50)    (show all 233)
idTitleAuthorsYear
1
Hidradenoma papilliferum of the orbit. (23387456)
2013
2
Nodular Hidradenoma of the Caruncle. (23715517)
2013
3
Benign hidradenoma masquerading as ductal breast cancer-a rare case of false-positive recurrence in cancer follow-up. (24102904)
2013
4
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
5
Hidradenoma papilliferum presenting as an eyelid mass. (22820442)
2012
6
A study of histopathologic spectrum of nodular hidradenoma. (21993337)
2012
7
Benign nodular hidradenoma of the face. (21415656)
2011
8
Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report. (21053567)
2010
9
From hidroacanthoma simplex to poroid hidradenoma: clinicopathologic and immunohistochemic study of poroid neoplasms and reappraisal of their histogenesis. (20571345)
2010
10
Fine-needle aspiration cytology of apocrine hidradenoma. (20698151)
2010
11
Clear cell hidradenoma of the axilla: a case report with literature review. (20592936)
2010
12
Giant benign nodular hidradenoma of the shoulder: A rare tumor in orthopedic practice. (21655004)
2010
13
Clear cell hidradenoma of the gluteal region: a case report. (19595274)
2009
14
Nodular hidradenoma of the breast: A case report with literature review. (23133109)
2009
15
Giant ectopic hidradenoma papilliferum on the scalp. (19785709)
2009
16
Dermoscopic features of clear cell hidradenoma. (18663309)
2008
17
Poroid hidradenoma: a case report with review of Japanese published work. (17584332)
2007
18
Clear cell hidradenoma of the ankle. (17761324)
2007
19
Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. 2005;43:202-205. (16670462)
2006
20
Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion. (15729701)
2005
21
Clear-cell hidradenoma of the forearm in a young boy. (16191000)
2005
22
Asymptomatic slowly enlarging nodule on the trunk: eccrine hidradenoma. (15009319)
2004
23
Malignant eccrine hidradenoma of neck causing acute heart failure. (12927299)
2003
24
Vulvar poroid hidradenoma. (12454609)
2002
25
Malignant nodular hidradenoma in a patient with neurofibromatosis type 1: a case report and review of the literature. (11710446)
2001
26
Poroid hidradenoma. (11277959)
2001
27
Extramammary Paget disease with underlying hidradenoma papilliferum: guilt by association? (11048981)
2000
28
Vulvar hidradenoma papilliferum. A review of 10.5 years' experience. (10986678)
2000
29
Malignant nodular hidradenoma of nose. (23119494)
1999
30
Ectopic hidradenoma papilliferum: a case report and review of the literature. (10411423)
1999
31
Fine needle aspiration cytology of poroid hidradenoma. (9684613)
1998
32
Poroid hidradenoma. A case presentation. (9791957)
1998
33
Clear cell hidradenoma simulating breast carcinoma: a diagnostic pitfall in fine-needle aspiration of breast. (8807256)
1996
34
Fine-needle aspiration diagnosis of a vulvar papillary hidradenoma: a case report. (8005045)
1994
35
Cytogenetic heterogeneity in a clear cell hidradenoma of the skin. (7923079)
1994
36
Clear cell hidradenoma: a tumor with basaliomatous changes in the overlying epidermis and follicular infundibula of surrounding skin. (1328338)
1992
37
Eccrine acrospiroma (clear cell hidradenoma) of the eyelid. Immunohistochemical and ultrastructural features. (1708858)
1991
38
Malignant hidradenoma--a case report demonstrating insidious histological and clinical progression. (1666865)
1991
39
Clear cell hidradenoma. A case report. (2176689)
1990
40
Nodular hidradenoma and hidradenocarcinoma. A 10-year review. (2984259)
1985
41
Combined papillary syringocystadenoma and hidradenoma. A case study. (198458)
1977
42
Syringeal hidradenoma--an unusual eccrine tumour. (4109429)
1971
43
Clear cell hidradenoma of the eyelid. (4298541)
1968
44
HIDRADENOMA OF THE ANAL CANAL. (14280233)
1965
45
A nodular hidradenoma of unusual histological type. (14022861)
1962
46
Clear-cell hidradenoma. (13588473)
1958
47
Hidradenoma of the vulva. (14933503)
1952
48
Hidradenoma and hidradenocarcinoma vulvae. (13008131)
1952
49
Hidradenoma of the vulva. (14782694)
1950
50
Hidradenoma of the vulva. (18106314)
1948

Variations for Hidradenoma

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Expression for genes affiliated with Hidradenoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hidradenoma

Search GEO for disease gene expression data for Hidradenoma.

Pathways for genes affiliated with Hidradenoma

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50PathCards, 53QIAGEN, 55Reactome, 38NCBI BioSystems Database, 57SinoBiological, 30KEGG, 60Thomson Reuters
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Pathways related to Hidradenoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7EGFR, ERBB2
2
Show member pathways
9.7ERBB2, EGFR
39.7ERBB2, EGFR
49.7ERBB2, EGFR
5
Show member pathways
9.7CREB1, MAML2
69.4MUC1, ERBB2, EGFR
7
Show member pathways
9.4EGFR, ERBB2, VIM
89.4EGFR, ERBB2, VIM
9
Show member pathways
9.3CREB1, ERBB2, EGFR
10
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.3CREB1, ERBB2, EGFR
119.3CREB1, ERBB2, EGFR
12
Show member pathways
9.3EGFR, ERBB2, CREB1
13
Show member pathways
9.3EGFR, ERBB2, CREB1
14
Show member pathways
9.3EGFR, ERBB2, CREB1
15
Show member pathways
Signaling Pathways in Glioblastoma38
9.3EGFR, ERBB2, CREB1
16
Show member pathways
9.3EGFR, ERBB2, CREB1
17
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3EGFR, ERBB2, CREB1
18
Show member pathways
9.3EGFR, ERBB2, CREB1
19
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.0EGFR, ERBB2, CREB1, MUC1
208.9EGFR, ERBB2, CREB1, MAML2
21
Show member pathways
8.8PIP, CREB1, ERBB2, EGFR
22
Show member pathways
8.8EGFR, ERBB2, CREB1, PIP
23
Show member pathways
8.2PIP, VIM, MUC1, CREB1, ERBB2, EGFR

Compounds for genes affiliated with Hidradenoma

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45Novoseek, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 24HMDB, 3BitterDB, 29IUPHAR
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Compounds related to Hidradenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1ag 14784510.5CREB1
2eosin4510.2MUC1, VIM
3s 1004510.2MUC1, VIM
4pd1587804510.1EGFR, ERBB2
5jnj 28871063 hydrochloride6110.1EGFR, ERBB2
6afatinib51 1111.1EGFR, ERBB2
7ag 1478 hydrochloride6110.1ERBB2, EGFR
8ag 4906110.1EGFR, ERBB2
9iressa6110.1ERBB2, EGFR
10pertuzumab45 51 1112.1ERBB2, EGFR
11pki-1664510.0ERBB2, EGFR
12hrgbeta14510.0EGFR, ERBB2
13quinazoline4510.0ERBB2, EGFR
14reticulin4510.0MUC1, VIM
15erbstatin459.9ERBB2, EGFR
16ganciclovir45 1110.9ERBB2, VIM, CREB1
17trastuzumab45 51 1111.8ERBB2, MUC1, EGFR
18biotin45 24 1111.8VIM, ERBB2, MUC1
19hydrocortisone45 3 61 1112.8MUC1, VIM, ERBB2
20mucicarmine459.8MUC1, VIM, PIP
21adriamycin459.8ERBB2, MUC1, VIM
22b 723459.8MUC1, VIM, PIP
234-hydroxytamoxifen459.8EGFR, VIM, ERBB2
24capecitabine45 51 1111.8ERBB2, EGFR
25gemcitabine45 51 1111.8EGFR, MUC1, ERBB2
26gefitinib45 51 1111.7EGFR, VIM, ERBB2
27anastrozole45 51 1111.7EGFR, ERBB2
28pd153035459.7ERBB2, EGFR
29thymidylate459.7EGFR, ERBB2, VIM
30formaldehyde45 2410.7ERBB2, MUC1, VIM
31dihydrotestosterone45 29 24 1112.6PIP, VIM, MUC1
32folate459.6VIM, MUC1, ERBB2
33exemestane45 51 61 1112.6ERBB2, EGFR
34herbimycin a45 6110.6EGFR, CREB1, ERBB2
35chloramphenicol45 3 51 1112.6VIM, MUC1, ERBB2, CREB1
36curcumin459.5CREB1, EGFR, ERBB2
37progestin459.5ERBB2, MUC1, EGFR, VIM
38rapamycin459.4EGFR, CREB1, VIM, ERBB2
39genistein45 29 61 3 24 1114.4VIM, CREB1, ERBB2, EGFR
40everolimus45 51 1111.4ERBB2, EGFR
41estradiol45 24 1111.4PIP, VIM, MUC1, CREB1
42cycloheximide459.3VIM, EGFR, ERBB2, CREB1
43agar459.2VIM, EGFR, ERBB2, MUC1, CREB1
44cyclic amp45 2410.2CREB1, MUC1, VIM, CRTC1
45vegf459.2MUC1, ERBB2, EGFR, VIM, CREB1
46tamoxifen45 51 29 1112.0VIM, EGFR, ERBB2, MUC1, PIP
47paraffin459.0PIP, ERBB2, EGFR, MUC1, VIM
48progesterone45 29 61 24 1113.0PIP, MUC1, VIM, ERBB2, EGFR
49testosterone45 61 24 1111.7VIM, MUC1, CREB1, ERBB2, EGFR, PIP
50estrogen458.6VIM, EGFR, PIP, ERBB2, CREB1, MUC1

GO Terms for genes affiliated with Hidradenoma

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16Gene Ontology
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Cellular components related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163248.9EGFR, ERBB2, MUC1, PIP

Biological processes related to Hidradenoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription by competitive promoter bindingGO:01094410.1CREB1, MUC1
2positive regulation of MAP kinase activityGO:0434069.7ERBB2, EGFR
3positive regulation of epithelial cell proliferationGO:0506799.7EGFR, ERBB2
4phosphatidylinositol-mediated signalingGO:0480159.6EGFR, ERBB2, CREB1
5fibroblast growth factor receptor signaling pathwayGO:0085439.5EGFR, ERBB2, CREB1
6Fc-epsilon receptor signaling pathwayGO:0380959.5EGFR, ERBB2, CREB1
7epidermal growth factor receptor signaling pathwayGO:0071739.5CREB1, ERBB2, EGFR
8activation of phospholipase C activityGO:0072029.4EGFR, CREB1
9neurotrophin TRK receptor signaling pathwayGO:0480119.4EGFR, ERBB2, CREB1
10axon guidanceGO:0074119.2EGFR, ERBB2, CREB1
11viral processGO:0160328.9SGTA, VIM, CREB1, CRTC1
12positive regulation of transcription from RNA polymerase II promoterGO:0459448.8EGFR, CRTC1, CREB1, MAML2

Molecular functions related to Hidradenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription cofactor activityGO:0037129.8CREB1, MUC1
2epidermal growth factor-activated receptor activityGO:0050069.8EGFR, ERBB2
3receptor signaling protein tyrosine kinase activityGO:0047169.7ERBB2, EGFR
4transmembrane receptor protein tyrosine kinase activityGO:0047149.4EGFR, ERBB2
5glycoprotein bindingGO:0019489.3EGFR, VIM, PIP
6protein bindingGO:0055156.7SGTA, CLEC2A, VIM, MUC1, CREB1, CRTC1

Products for genes affiliated with Hidradenoma

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Sources for Hidradenoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet