MCID: HDR004
MIFTS: 41

Hidradenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Hidradenoma

MalaCards integrated aliases for Hidradenoma:

Name: Hidradenoma 12 51 14
Adenoma, Sweat Gland 41 69
Benign Neoplasm of Sweat Gland 69
Hidradenoma of Skin 12
Sweat Gland Adenoma 12
Eccrine Acrospiroma 69
Syringoadenoma 12

Classifications:



Summaries for Hidradenoma

MalaCards based summary : Hidradenoma, also known as adenoma, sweat gland, is related to clear cell hidradenoma and nodular hidradenoma. An important gene associated with Hidradenoma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Development EGFR signaling pathway. Affiliated tissues include skin, breast and lymph node, and related phenotype is Decreased cell migration.

Related Diseases for Hidradenoma

Diseases related to Hidradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 clear cell hidradenoma 33.8 CRTC1 MAML2
2 nodular hidradenoma 32.5 KRT7 MUC1 VIM
3 hidradenocarcinoma 32.5 KRT7 VIM
4 syringocystadenoma papilliferum 32.1 MUC1 VIM
5 syringoma 30.0 MUC1 VIM
6 paget disease, extramammary 29.5 KRT7 MUC1
7 cystadenoma 29.4 KRT7 MUC1
8 adenosquamous carcinoma 29.1 KRT7 MUC1
9 spiradenoma 28.9 KRT7 MUC1 VIM
10 dermoid cyst 28.9 KRT7 MUC1 VIM
11 mucoepidermoid carcinoma 28.8 CRTC1 KRT7 MAML2 MUC1
12 renal cell carcinoma, nonpapillary 28.3 AKT1 KRT7 MUC1 VIM
13 papillary hidradenoma 12.1
14 vulvar nodular hidradenoma 11.9
15 eccrine acrospiroma 11.3
16 acrospiroma 11.2
17 lacrimal gland mucoepidermoid carcinoma 10.4 CRTC1 MAML2
18 schneiderian carcinoma 10.4 CRTC1 MAML2
19 cervical adenosquamous carcinoma 10.4 CRTC1 MAML2
20 apocrine adenoma 10.3 MUC1 PIK3CA
21 aggressive digital papillary adenocarcinoma 10.3 MUC1 PIK3CA
22 malignant peritoneal mesothelioma 10.2 MUC1 VIM
23 papillary tumor of the pineal region 10.2 MUC1 VIM
24 ossifying fibromyxoid tumor 10.2 MUC1 VIM
25 biphasic synovial sarcoma 10.2 MUC1 VIM
26 fibrous meningioma 10.2 MUC1 VIM
27 chordoid meningioma 10.2 MUC1 VIM
28 proteus syndrome 10.2 AKT1 PIK3CA
29 clear cell meningioma 10.2 MUC1 VIM
30 endometrial mucinous adenocarcinoma 10.2 MUC1 VIM
31 adenofibroma 10.2 MUC1 VIM
32 myxopapillary ependymoma 10.1 MUC1 VIM
33 sarcomatoid mesothelioma 10.1 MUC1 VIM
34 anaplastic ependymoma 10.1 MUC1 VIM
35 pleomorphic liposarcoma 10.1 MUC1 VIM
36 perivascular epithelioid cell tumor 10.1 MUC1 VIM
37 reticulum cell sarcoma 10.1 MUC1 VIM
38 sertoli cell tumor 10.1 MUC1 VIM
39 chondroid chordoma 10.1 MUC1 VIM
40 mesenchymal chondrosarcoma 10.1 MUC1 VIM
41 extraskeletal ewing sarcoma 10.1 MUC1 VIM
42 perineurioma 10.1 MUC1 VIM
43 dendritic cell tumor 10.1 MUC1 VIM
44 cerebral primitive neuroectodermal tumor 10.1 MUC1 VIM
45 hemangiopericytoma, malignant 10.1 MUC1 VIM
46 salivary gland cancer 10.1 AKT1 CRTC1 MAML2
47 polymorphous low-grade adenocarcinoma 10.1 MUC1 VIM
48 malignant spiradenoma 10.1 KRT7 PIK3CA
49 integumentary system benign neoplasm 10.0 KRT7 MAML2
50 osteofibrous dysplasia 10.0 MUC1 VIM

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to Hidradenoma

Symptoms & Phenotypes for Hidradenoma

GenomeRNAi Phenotypes related to Hidradenoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.92 AKT1 MUC1 PIK3CA VIM

Drugs & Therapeutics for Hidradenoma

Search Clinical Trials , NIH Clinical Center for Hidradenoma

Cochrane evidence based reviews: adenoma, sweat gland

Genetic Tests for Hidradenoma

Anatomical Context for Hidradenoma

MalaCards organs/tissues related to Hidradenoma:

38
Skin, Breast, Lymph Node, Salivary Gland, Lung, Heart, Smooth Muscle

Publications for Hidradenoma

Articles related to Hidradenoma:

(show top 50) (show all 298)
# Title Authors Year
1
Clear Cell Hidradenoma: Characteristic Imaging Features on Ultrasonography, Computed Tomography, and Magnetic Resonance Imaging. ( 29388236 )
2018
2
18F-FDG PET/CT Imaging of Hidradenocarcinoma Arising From Preexisting Hidradenoma of the Knee. ( 29166328 )
2018
3
Ultrasound Diagnosis of Nodular Hidradenoma. ( 29183622 )
2017
4
Nodular hidradenoma: Dermoscopic presentation. ( 28087028 )
2017
5
Poroid Hidradenoma: An Uncommon Cutaneous Adnexal Neoplasm. ( 28216741 )
2017
6
A Large Lumbar Adnexal Neoplasm Presenting Characteristics of Eccrine Poroma and Poroid Hidradenoma. ( 29057137 )
2017
7
Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor. ( 28648934 )
2017
8
Sonographic Characteristics of Apocrine Nodular Hidradenoma of the Skin. ( 28880402 )
2017
9
Hidradenoma of the Chin. ( 28570408 )
2017
10
A case of cutaneous metastatic lung cancer difficult to distinguish from malignant nodular hidradenoma. ( 28664659 )
2017
11
Malignant Clear Cell Hidradenoma of the Breast. ( 28409065 )
2017
12
The utility of using immunohistochemistry in the differentiation of metastatic, cutaneous clear cell renal cell carcinoma and clear cell hidradenoma. ( 28374447 )
2017
13
Hidradenoma papilliferum of the vulva in a postpartum woman: A case report. ( 28287283 )
2017
14
A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance. ( 29079171 )
2017
15
Clear cell hidradenoma of the breast with MAML2 gene rearrangement. ( 27914681 )
2017
16
Mucinous hidradenoma in a child-A case report and review of the literature. ( 28429507 )
2017
17
Case of chondroid syringoma mimicking as nodular hidradenoma: A diagnostic pitfall on cytopathology. ( 28772003 )
2017
18
Hidradenoma Papilliferum: A Case Report of an Uncommon Perianal Lesion. ( 26874122 )
2016
19
Cutaneous hidradenoma: a study of 21 neoplasms revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions. ( 27402217 )
2016
20
Vulvar hidradenoma papilliferum (HP) is located on the sites of mammary-like anogenital glands (MLAGs): Analysis of the photographs of 52 tumors. ( 26944596 )
2016
21
Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up. ( 27010690 )
2016
22
Ultrasonographic diagnosis of nodular hidradenoma. ( 26662046 )
2016
23
Giant metastasizing malignant hidradenoma in a child. ( 27730041 )
2016
24
PIK3CA and AKT1 mutations in hidradenoma papilliferum. ( 27742746 )
2016
25
Rare Adnexal Tumor of the Breast: Poroid Hidradenoma. ( 27943519 )
2016
26
Dermoscopy of Nodular Hidradenoma, a Great Masquerader: A Morphological Study of 28 Cases. ( 26606241 )
2016
27
A Weeping Tumor in a Young Girl: An Unusual Presentation of Nodular Hidradenoma. ( 27293255 )
2016
28
A Rare Case of Cutaneous Oncocytic Hidradenoma. ( 28035705 )
2016
29
Tubulopapillary Hidradenoma-like Tumour of the Mandible: A Case Report and Literature Review. ( 27943162 )
2016
30
A reddish nodule with viscous fluid secretion. Solida89cystic hidradenoma (SCH). ( 26266940 )
2016
31
A case of nodular hidradenoma of the auricle mimicking squamous cell carcinoma. ( 27350422 )
2016
32
Hidradenoma Papilliferum With Oncocytic Metaplasia: A Histopathological and Immunohistochemical Study. ( 27097337 )
2016
33
Nodular hidradenoma arising on the site of a BCG scar. ( 27523405 )
2016
34
Hidradenoma Papilliferum: A Clinicopathologic Study of 264 Tumors From 261 Patients, With Emphasis on Mammary-Type Alterations. ( 26863059 )
2016
35
LYMPH NODE LOCATION OF A CLEAR CELL HIDRADENOMA: REPORT OF A PATIENT AND REVIEW OF LITERATURE. ( 27080562 )
2016
36
Mutations of cancer-related genes in benign tumors: the example of hidradenoma papilliferum. ( 27865794 )
2016
37
Ultrasound Image of Poroid Hidradenoma. ( 26762692 )
2016
38
Lymph Node Involvement by a Clear Cell Nodular Hidradenoma-Like Tumor of Uncertain Malignant Potential. ( 28033155 )
2016
39
Frequent PIK3CA Activating Mutations in Hidradenoma Papilliferums. ( 27184479 )
2016
40
Hidradenoma masquerading digital ganglion cyst: A rare phenomenon. ( 27625783 )
2016
41
Clear Cell Hidradenoma of the Ear Lobule: An Unusual Site of Presentation. ( 26435960 )
2015
42
Hidradenoma papilliferum associated with pregnancy: a case report. ( 26265265 )
2015
43
Mutations in genes encoding PI3K-AKT and MAPK signaling define anogenital papillary hidradenoma. ( 26493284 )
2015
44
Hidradenoma of the Breast: A Source of Diagnostic Confusion. ( 26391316 )
2015
45
Nodular hidradenoma of left toe. ( 25671057 )
2015
46
Clear cell hidradenoma of breast mimicking atypical breast lesion: a diagnostic pitfall in breast cytology. ( 25002948 )
2014
47
Giant eccrine hidradenoma mimicking a malignant tumor of the salivary gland. ( 25075376 )
2014
48
The aesthetic and oncological challenges in the management of an atypical nodular hidradenoma of the pinna. ( 25114470 )
2014
49
Clear cell hidradenoma on the palm. ( 24966646 )
2014
50
Hidradenoma papilliferum of the vulva. ( 25396149 )
2014

Variations for Hidradenoma

Expression for Hidradenoma

Search GEO for disease gene expression data for Hidradenoma.

Pathways for Hidradenoma

Pathways related to Hidradenoma according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1 12.3 KRT7 MUC1 VIM
2
Show member pathways
12.22 AKT1 MUC1 PIK3CA
3
Show member pathways
12.19 AKT1 PIK3CA VIM
4 12.17 AKT1 CRTC1 PIK3CA
5 11.96 AKT1 PIK3CA VIM
6
Show member pathways
11.62 AKT1 PIK3CA
7 11.3 AKT1 PIK3CA
8 11.29 AKT1 PIK3CA
9 11.26 AKT1 PIK3CA
10 11.24 AKT1 PIK3CA
11 11.12 AKT1 PIK3CA
12 11.09 AKT1 PIK3CA
13
Show member pathways
11.09 AKT1 PIK3CA
14 11.05 AKT1 PIK3CA
15 11.03 AKT1 PIK3CA
16 11 AKT1 PIK3CA
17 10.97 AKT1 PIK3CA
18 10.94 AKT1 PIK3CA
19 10.87 AKT1 PIK3CA
20 10.86 AKT1 MUC1 VIM
21 10.85 AKT1 PIK3CA
22 10.78 AKT1 PIK3CA
23 10.73 AKT1 PIK3CA
24 10.68 AKT1 PIK3CA
25 10.54 AKT1 PIK3CA
26 10.41 AKT1 PIK3CA
27 10.21 AKT1 VIM

GO Terms for Hidradenoma

Biological processes related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase B signaling GO:0043491 9.32 AKT1 PIK3CA
2 phosphatidylinositol 3-kinase signaling GO:0014065 9.26 AKT1 PIK3CA
3 energy homeostasis GO:0097009 9.16 CRTC1 PIK3CA
4 negative regulation of macroautophagy GO:0016242 8.96 AKT1 PIK3CA
5 anoikis GO:0043276 8.62 AKT1 PIK3CA

Sources for Hidradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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