MCID: HGH003

High Blood Pressure malady

Summaries for High Blood Pressure

Sources:
23MedlinePlus, 2CDC, 44Wikipedia, 22MalaCards
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MedlinePlus: Blood pressure is the force of your blood pushing against the walls of your arteries. each time your heart beats, it pumps out blood into the arteries. your blood pressure is highest when your heart beats, pumping the blood. this is called systolic pressure. when your heart is at rest, between beats, your blood pressure falls. this is the diastolic pressure. your blood pressure reading uses these two numbers, the systolic and diastolic pressures. usually they are written one above or before the other. a reading of 120/80 or lower is normal blood pressure 140/90 or higher is high blood pressure between 120 and 139 for the top number, or between 80 and 89 for the bottom number is prehypertension high blood pressure usually has no symptoms, but it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. you can control high blood pressure through healthy lifestyle habits and taking medicines, if needed. nih: national heart, lung, and blood institute23

MalaCards: High Blood Pressure, also known as hypertensive disease, is related to hypertension and hypertensive heart disease. An important gene associated with High Blood Pressure is RGS2 (regulator of G-protein signaling 2, 24kDa), and among its related pathways are Development EDNRB signaling and Relaxin Pathway. The drugs bendroflumethiazide and diltiazem and the compounds glucose and nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and lung, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

CDC: About 1 in 3 U.S. adults—as estimated 68 million—have high blood pressure1, which increases the risk for heart disease and stroke, leading causes of death in the United States.22

Wikipedia: Hypertension (HTN) or high blood pressure, sometimes called arterial hypertension, is a chronic medical...44 more...

Aliases & Descriptions for High Blood Pressure

Sources:
2CDC, 17Genetics Home Reference, 23MedlinePlus, 43UMLS
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high blood pressure 17 23
hypertensive disease 43

Related Diseases for High Blood Pressure

Sources:
13GeneCards, 14GeneDecks
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Diseases related to high blood pressure by text searches and GeneDecks gene sharing:

(show top 50)    (show all 422)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension32.2REN, NOS3, ACE, AGT, AGTR1, RGS2
2hypertensive heart disease30.5NR3C2, ACE, AGT, AGTR1, NPPB
3cushing's syndrome30.3REN, RETN, LPL, BGLAP, LEP, INS
4adrenal gland hyperfunction30.3BGLAP, LEP, NR3C2
5hypertensive nephropathy29.9ALB, ACE
6hypertensive retinopathy29.5ALB, ACE
7malignant hypertension29.2REN, ACE
8renovascular hypertension29.1REN, ACE, AGTR1
9fibromuscular dysplasia28.9REN, ACE, AGT, AGTR1
10chronic kidney failure28.8REN, LPL, LEP, INS, ALB, EPO
11nephrosclerosis28.8INS, NR3C2, ACE, AGTR1
12portal hypertension28.7RETN, ALB, NOS3, EDN1, AGTR1
13pulmonary hypertension28.7NOS3, EDN1, AGT, NPPB
14apparent mineralocorticoid excess syndrome28.6REN, NR3C2
15lupus nephritis28.4ALB, NOS3, EDN1, ACE, AGT, AGTR1
16turner syndrome28.1REN, BGLAP, LEP, INS, PTH
17cor pulmonale28.0REN, EDN1, ACE, AGTR1, NPPB
18liver cirrhosis27.8REN, RETN, ALB, NR3C2, EDN1
19pheochromocytoma27.6REN, LEP, SP1, NISCH, EDN1, ACE
20pre-eclampsia27.6NOS3, EDN1, AGT
21renal hypertension27.1REN, EDN1, ACE
22ischemic heart disease27.1COG2, RETN, LPL, NOS3, EDN1, ACE
23hypertension with brachydactyly26.8REN, NR3C2
24morbid obesity26.8RETN, LPL, LEP, INS, ADRB3
25abdominal aortic aneurysm26.0REN, RETN, LEP, ALB, NOS3, EDN1
26glomerulonephritis25.0REN, BGLAP, INS, ALB, SP1, NOS3
27end stage renal failure24.6RETN, BGLAP, LEP, INS, ALB, PTH
28polycystic ovary syndrome23.7REN, RETN, LPL, BGLAP, LEP, INS
29insulin resistance23.4COG2, REN, RETN, LPL, BGLAP, LEP
30coronary heart disease23.0COG2, RETN, LPL, BGLAP, LEP, INS
31obesity22.9COG2, REN, RETN, LPL, BGLAP, LEP
32essential hypertension22.3COG2, REN, RETN, LPL, BGLAP, LEP
33diabetes mellitus21.6COG2, REN, RETN, LPL, BGLAP, LEP
34myocardial infarction21.1COG2, REN, RETN, LPL, LEP, INS
35aldosteronism20.8REN, RETN, INS, MAP2K1, ALB, AKT1
36posterior urethral valves13.4ACE, AGT, AGTR1
37meningococcal infection13.4AGT, AGTR1, ADD1
38mitral valve disease13.4ACE, AGT, AGTR1
39nephropathy-hypertension13.4ALB, ACE
40vitamin d-dependent rickets type ii13.4BGLAP, PTH
41raynaud disease13.3EDN1, AGTR1
42hypertensive encephalopathy13.3AGTR1, EPO
43chronic rapidly progressive glomerulonephritis13.3ALB, ACE, AGTR1
44focal segmental glomerulosclerosis13.3ALB, ACE, AGTR1
45prinzmetal's variant angina13.2NOS3, EDN1
46peripheral arterial occlusive disease13.2EDN1, ACE, CS
47hyperphosphatemia13.2BGLAP, ALB, PTH
48neurocirculatory asthenia13.2ACE, AGT, AGTR1
49lipoatrophic diabetes13.2RETN, LEP, INS
50proliferative glomerulonephritis13.2ALB, EDN1, AGTR1

Graphical network of the top 20 diseases related to high blood pressure:



Graphical network of diseases related to high blood pressure

Clinical Features for High Blood Pressure

Drugs & Therapeutics for High Blood Pressure

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for high blood pressure

Drug clinical trials:

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Search NIH Clinical Center for high blood pressure

Search CenterWatch for high blood pressure

Inferred drug relations via UMLS/NDF-RT:

43 28 [cv490] antihypertensives,other, acebutolol, acebutolol hydrochloride, amiloride, amiloride hydrochloride, amlodipine, amlodipine besylate, atenolol, benazepril, benazepril hydrochloride, bendroflumethiazide, benzthiazide, bepridil, bepridil hydrochloride, betaxolol, betaxolol hydrochloride, bisoprolol, bisoprolol fumarate, bumetanide, candesartan, candesartan cilexetil, carteolol, carteolol hydrochloride, carvedilol, carvedilol phosphate, chlorothiazide, chlorothiazide sodium, chlorthalidone, clonidine, clonidine hcl pwdr [va product], clonidine hydrochloride, coenzyme q10, cyclothiazide, deserpidine, diltiazem, diltiazem hcl, diltiazem hydrochloride, diltiazem maleate, ditiaz, dong quai, doxazosin, doxazosin mesylate, eplerenone, eprosartan, eprosartan mesylate, esmolol, esmolol hydrochloride, ethacrynate sodium, ethacrynic acid, felodipine, fish oil, fosinopril, fosinopril sodium, furosemide, garlic oil, guanabenz, guanabenz acetate, guanadrel, guanadrel sulfate, guanethidine, guanethidine monosulfate, guanfacine, guanfacine hydrochloride, hydrochlorothiazide, hydroflumethiazide, indapamide, irbesartan, isradipine, lisinopril, losartan, losartan potassium, methyclothiazide, methyldopa, methyldopate hydrochloride, metolazone, metoprolol, metoprolol succinate, metoprolol tartrate, mibefradil, mibefradil dihydrochloride, moexipril, moexipril hydrochloride, nadolol, nicardipine, nicardipine hydrochloride, nifedipine, nisoldipine, olmesartan, olmesartan medoxomil, penbutolol, penbutolol sulfate, perindopril, perindopril erbumine, pindolol, polythiazide, prazosin, prazosin hydrochloride, propranolol, propranolol hydrochloride, quinapril, quinapril hydrochloride, quinethazone, ramipril, reserpine, spironolactone, spironolactone pwdr [va product], telmisartan, terazosin, terazosin hydrochloride, timolol, timolol hemihydrate, timolol maleate, torsemide, trandolapril, triamterene, trichlormethiazide, valsartan, verapamil, verapamil hydrochloride

Genetic Tests for High Blood Pressure

Anatomical Context for High Blood Pressure

Sources:
22MalaCards
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MalaCards organs/tissues related to high blood pressure:

22
Heart, Kidney, Lung

Phenotypes for genes affiliated with High Blood Pressure

Sources:
25MGI
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Publications for genes affiliated with High Blood Pressure

Sources:
35PubMed
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Articles related to high blood pressure:

(show all 31)
idTitleAuthorsYearAffiliating Genes
1Treating high blood pressure in kidney patients: evi dence and implications (19460476)MarA-n R.... GarcA-a-Melendreras S.2009ALB
2Are RGS2 gene polymorphisms associated with high blood pressure in an ethnicity- and gender-specific manner? (19023274)Hahntow I.N.... Michel M.C.2009RGS2
3Absence of evidence for an association between resistin gene variants and insulin resistance in an Asian population with low and high blood pressure. (18501464)Kimbell J.L.... Curb J.D.2008RETN
4The alpha-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure. (17472579)Pescatello L.S.... Thompson P.D.2007ADD1
5The -318 C>G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy. (16565233)Menzaghi C.... Trischitta V.2006GNAI2, SP1
6High blood pressure in acute ischemic stroke and underlying disorders. (16888375)Toyoda K.... Ibayashi S.2006AGTR1
7Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. (16216958)Dries D.L.... Drazner M.H.2005NPPB, CORIN
8High blood pressure, bone-mineral loss and insulin resistance in women. (16335884)Gotoh M.... Takahashi M.2005PTH, BGLAP
9Obesity and high blood pressure: a clinical phenotype for the insulin resistance syndrome in African Americans. (15249791)Campbell K.L.... Falkner B.2004ALB
10Elevated plasma leptin levels associated with high blood pressure and TG rich lipoproteins but not associated with plasma gonadotropins, estradiol and cortisol levels in peri- and postmenopausal lean women with undefined symptoms. (18084865)Ushiroyama T.... Ueki M.2004LEP
11WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. (14611643)Vitari A.C.... Alessi D.R.2004AKT1, MAP2K1, WNK1
12Treating high blood pressure in diabetes: the evidence. (16222604)Adler A.I.2002ACE
13Is cardiovascular remodeling in patients with essential hypertension related to more than high blood pressure? A LIFE substudy. Losartan Intervention For Endpoint-Reduction in Hypertension. (12228792)Olsen M.H.... Ibsen H.2002REN
14Relationship of the Trp64Arg polymorphism of the beta3-adrenoceptor gene to central adiposity and high blood pressure: interaction with age. Cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study. (11288809)Strazzullo P.... Farinaro E.2001ADRB3
15Weight reduction improves high blood pressure and microalbuminuria in hypertensive patients with obesity (11431901)Ohashi H.... Watanabe S.2001ALB
16Glomerular hyperfiltration, high renin, and low- extracellular volume in high blood pressure. (10775568)Harrap S.B.... Watt G.C.2000REN
17Platelet aggregation in young men with contrasting predisposition to high blood pressure. (10090337)Dockrell M.E.... Webb D.J.1999EDN1
18How to use calcium antagonists in hypertension: putting the JNC-VI guidelines into practice. Joint National Committee for the Prevention, Detection, Evaluation and Treatment of High Blood Pressure. (10551431)Singh V.... Frishman W.H.1999ACE
19Relationship between medical treatment compliance and the degree of control in patients with high blood pressure, non-insulin dependent diabetes mellitus and dyslipidemia (9859088)PiA+eiro F.... Merino J.1998INS
20High blood pressure and muscle morphology/metabolism--causal relationship or only associated factors? (9649908)Krotkiewski M.... Holm G.1998LPL, CS
21Objectives of high blood pressure treatment: left ventricular hypertrophy, diastolic function, and coronary reserve. (9683053)Strauer B.E.... Schwartzkopff B.1998ACE
22Trends in antihypertensive drug use in the United States: do the JNC V recommendations affect prescribing? Fifth Joint National Commission on the Detection, Evaluation, and Treatment of High Blood Pressure. (9388150)Siegel D.... Lopez J.1997ACE
23Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. (9262401)Ledent C.... Parmentier M.1997ADORA2A
24Prolonged reduction of high blood pressure with human nitric oxide synthase gene delivery. (9314409)Lin K.F.... Chao J.1997NOS3
25Mineralocorticoids, salt and high blood pressure. (8732997)GA^mez-SA!nchez E.P.... Gomez-Sanchez C.E.1996NR3C2
26Chronic control of high blood pressure in the spontaneously hypertensive rat by delivery of angiotensin type 1 receptor antisense. (8790439)Iyer S.N.... Raizada M.K.1996AGTR1
27High blood pressure and cardiovascular risk factors in an adult population of Mexico City. Characteristics of the studied population. (8696067)Yamamoto-Kimura L.... Posadas-Romero C.1996COG2
28Future management of high blood pressure. (8872300)Johnston C.I.1996NISCH
29Genetic variation at the angiotensinogen locus in relation to high blood pressure and myocardial infarction: the ECTIM Study. (7622852)Tiret L.... Cambien F.1995AGT
30The angiotensin I converting enzyme gene and predisposition to high blood pressure. (8384602)Harrap S.B.... Watt G.C.1993ACE
31The fifth report of the Joint National Committee on D etection, Evaluation, and Treatment of High Blood Pressure: insights and highli ghts from the chairman. (8339452)Gifford R.W.1993EPO

Expression for genes affiliated with High Blood Pressure

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with High Blood Pressure

Pathways for genes affiliated with High Blood Pressure

Sources:
10EMD Millipore, 36QIAGEN, 34PharmGKB, 20KEGG, 41Thomson Reuters, 37R&D Systems
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Pathways related to high blood pressure according to GeneDecks:

(show all 23)
idPathwayScoreTop Affiliating Genes
1Development EDNRB signaling1010.1AKT1, GNAI2, MAP2K1
2Relaxin Pathway3610.1MAP2K1, NOS3, GNAI2
3ACE Inhibitor Pathway, Pharmacodynamics3410.0NR3C2, AGTR1
4CMV and MAPK Pathways369.8MAP2K1, SP1, AKT1
5Progesterone-mediated oocyte maturation209.7MAP2K1, INS, GNAI2
6Development_Angiotensin activation of ERK419.7AGTR1, MAP2K1, GNAI2, AGT
7Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1419.7AKT1, NOS3, MAP2K1
8VEGF Family Ligands and Receptor Interactions369.7AKT1, NOS3, MAP2K1
9Renin-angiotensin system209.6REN, ACE, AGT, AGTR1
10Development Endothelin-1/EDNRA transactivation of EGFR109.6MAP2K1, EDN1, AKT1, SP1
11Development_Endothelin-1/EDNRA transactivation of EGFR419.6EDN1, SP1, AKT1, MAP2K1
12Development_EDNRB signaling419.5MAP2K1, EDN1, NOS3, AKT1, GNAI2
13Development_Endothelin-1/EDNRA signaling419.4NPPB, EDN1, MAP2K1, GNAI2, AKT1
14Development Endothelin-1/EDNRA signaling109.4MAP2K1, GNAI2, AKT1, EDN1, NPPB
15NFAT and Cardiac Hypertrophy369.4GNAI2, MAP2K1, AGT, AKT1, EDN1
16Transcription Receptor-mediated HIF regulation109.4MAP2K1, INS
17cAMP Pathway369.2RGS2, ADRB3, ADD1, NOS3, MAP2K1, AKT1
18Transcription_Receptor-mediated HIF regulation419.2AKT1, INS, MAP2K1
19Development Leptin signaling via JAK/STAT and MAPK cascades109.2MAP2K1, LEP, EDN1
20Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics349.1ACE, REN, NR3C2, AGT, NOS3, AGTR1
21JAK-STAT Pathway368.7MAP2K1, AGT, AKT1, AGTR1, SP1, EPO
22Adipocytokines & Insulin Signaling378.6RETN, LEP, INS, MAP2K1, AKT1
23AMPK Enzyme Complex Pathway368.5LEP, INS, GNAI2, NOS3, AKT1

Compounds for genes affiliated with High Blood Pressure

Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to high blood pressure according to GeneDecks:

(show top 50)    (show all 242)
idCompoundScoreTop Affiliating Genes
1glucose32 10.6NISCH, PTH
2nitroglycerin32 9 9 12.6COG2
3isoproterenol32 9 9 11.9AKT1, ADORA2A, ADRB3, PTH
4estradiol32 9 18 9 12.7REN, MAP2K1, AGT, AGTR1
5captopril32 42 9 9 12.2REN, ALB, NR3C2, NISCH, ACE, AGT
6l-nmma32 9.2NPPB, EDN1, AGT, AGTR1
7lisinopril32 9 18 9 12.0ACE, NPPB, AGTR1, ALB, AGT, REN
8irbesartan32 9 9 10.9AGT, ACE, ALB, REN, COG2, AGTR1
9perindopril32 34 9 9 11.8AGTR1, AGT, ACE, NOS3, REN, NPPB
10candesartan32 9 9 10.8REN, ALB, NOS3, ACE, AGT, AGTR1
11amlodipine32 9 18 9 11.8ALB, ACE, NOS3, NPPB, AGTR1, AGT
12spironolactone32 42 34 9 9 12.7ADD1, NPPB, NR3C2, ACE, AGTR1, ALB
13trandolapril32 9 9 10.7REN, NPPB, AGTR1, EDN1, ACE
14valsartan32 42 9 9 11.6ACE, NPPB, REN, ALB, EDN1, AGT
15ramipril32 9 9 10.5REN, AGTR1, ACE, ALB, INS, NPPB
16ang ii32 8.5REN, AGT, AGTR1, NPPB, ACE, EDN1
17testosterone32 9 18 9 11.4AKT1, MAP2K1, BGLAP, LPL, PTH, COG2
18atorvastatin32 34 9 18 9 12.4COG2, RETN, LPL, NOS3, EDN1, NPPB
19enalapril32 9 9 10.2EDN1, ACE, AGT, AGTR1, NPPB, EPO
20furosemide32 42 34 9 18 9 13.2ACE, ALB, ADD1, SLC12A3, NPPB, REN
21hydrochlorothiazide32 34 9 18 9 12.0REN, BGLAP, ALB, NR3C2, AGT, AGTR1
22sodium32 18 8.7ADD1, WNK1, SLC12A3, NPPB, AGTR1, AGT
23metformin32 34 9 9 10.7COG2, LPL, ACE, AKT1, LEP, INS
24actinomycin d32 7.7AKT1, NPPB, AGTR1, AGT, NOS3, NR3C2
25epinephrine32 9 18 9 10.7NPPB, ADRB3, SP1, INS, LEP, NISCH
268-isoprostane32 7.7RETN, NPPB, LEP, AGTR1, EDN1, NOS3
27vitamin d32 7.5NOS3, SP1, NR3C2, ALB, AGTR1, NPPB
28telmisartan32 9 9 9.5NPPB, AGTR1, COG2, REN, LEP, INS
29thiazide32 7.5LPL, BGLAP, INS, NR3C2, ACE, AGTR1
30thyroxine32 18 8.4NPPB, PTH, COG2, INS, BGLAP, LEP
31phenylephrine32 9 18 9 10.4LEP, MAP2K1, AKT1, NOS3, EDN1, AGT
32alanine32 7.4COG2, RETN, BGLAP, INS, MAP2K1, NR3C2
33losartan32 34 9 9 10.2REN, LEP, ALB, AKT1, NR3C2, NPPB
34phosphatidylinositol32 7.2AKT1, MAP2K1, NOS3, LEP, RETN, EDN1
35potassium32 9 18 9 10.2WNK1, SLC12A3, AGT, ACE, NISCH, NR3C2
36prostacyclin32 7.1AGT, ACE, EDN1, SP1, NOS3, AKT1
37acetylcholine32 9 18 9 10.1ADORA2A, AKT1, LPL, LEP, SP1, NOS3
38rosiglitazone32 9 18 9 10.1NOS3, NPPB, INS, LEP, AGTR1, LPL
39nitric oxide32 9 18 9 10.1AGTR1, ADRB3, ADD1, ADORA2A, NPPB, CS
40creatinine32 6.8EPO, NPPB, AGTR1, AGT, ACE, EDN1
41cyclosporin a32 42 7.7EPO, EDN1, COG2, LPL, BGLAP, LEP
42calcium32 9 18 9 9.7AGTR1, CS, NPPB, SLC12A3, WNK1, ADORA2A
43norepinephrine32 9 18 9 9.2NPPB, ADORA2A, ADRB3, AGTR1, AGT, ACE
44vegf32 6.1REN, AKT1, SP1, EPO, ADORA2A, NPPB
45cholesterol32 9 18 9 9.1ADRB3, ADD1, ADORA2A, CS, AGTR1, AGT
46estrogen32 6.0COG2, ADRB3, NPPB, NOS3, NR3C2, PTH
47dexamethasone32 42 34 9 9 9.9LEP, MAP2K1, INS, BGLAP, LPL, RETN
48lipid32 5.8ADRB3, ADD1, ADORA2A, COG2, RETN, LPL
49arginine32 5.5NOS3, NR3C2, SP1, PTH, AKT1, MAP2K1
50serine32 5.3ADD1, AGTR1, AGT, CORIN, NOS3, LEP

GO Terms for genes affiliated with High Blood Pressure

Sources:
12Gene Ontology
See all sources

Cellular components related to high blood pressure according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.3EPO, LPL, BGLAP, LEP, INS, ALB
2extracellular spaceGO:0056155.8EPO, LPL, BGLAP, LEP, INS, ALB

Biological processes related to high blood pressure according to GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1regulation of norepinephrine secretionGO:01406110.4ADORA2A, AGT
2astrocyte activationGO:04814310.3ADORA2A, AGT
3regulation of renal output by angiotensinGO:00201910.3AGT, ACE
4blood vessel remodelingGO:00197410.3AGT, NOS3
5positive regulation of NAD(P)H oxidase activityGO:03386410.1AGT, AGTR1
6regulation of blood vessel size by renin-angiotensinGO:00203410.0AGT, AGTR1
7regulation of renal sodium excretionGO:03581310.0AGT, AGTR1, CORIN
8artery smooth muscle contractionGO:01482410.0EDN1, AGT
9positive regulation of urine volumeGO:03581010.0NPPB, ADORA2A, EDN1
10renin-angiotensin regulation of aldosterone productionGO:0020189.9AGTR1, AGT, REN
11adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.9ADRB3, ADORA2A, PTH
12regulation of systemic arterial blood pressure by endothelinGO:0031009.9NOS3, EDN1
13regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.8ACE, AGTR1
14positive regulation of renal sodium excretionGO:0358159.8EDN1, ADORA2A, NPPB, AGT
15positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGTR1, AGT, LPL
16regulation of vasodilationGO:0423129.8ACE, NPPB, AGTR1
17response to fluid shear stressGO:0344059.8NOS3, AKT1
18agingGO:0075689.7ADRB3, EPO, NOS3, AGT
19positive regulation of glycogen biosynthetic processGO:0457259.7PTH, INS, AKT1
20response to testosterone stimulusGO:0335749.6EPO, EDN1, BGLAP
21positive regulation of glucose importGO:0463269.6INS, AKT1, PTH
22eating behaviorGO:0427559.6ADRB3, ADORA2A, LEP
23kidney developmentGO:0018229.6AGT, AGTR1, REN, ACE
24regulation of vasoconstrictionGO:0192299.5EDN1, AGT, AGTR1, ACE
25ovulation from ovarian follicleGO:0015429.4LEP, NOS3
26positive regulation of nitric oxide biosynthetic processGO:0454299.4INS, AKT1, EDN1
27positive regulation of cellular protein metabolic processGO:0322709.2AGT, INS, AGTR1, AKT1
28cell-cell signalingGO:0072679.1ADORA2A, AGT, EDN1, PTH, INS
29positive regulation of MAPK cascadeGO:0434109.0ADRB3, AGT, INS, LEP
30response to drugGO:0424938.9EDN1, ADORA2A, NPPB, NOS3, BGLAP, LPL
31regulation of blood pressureGO:0082178.8NPPB, REN, ACE, NISCH, CORIN, NOS3
32glucose metabolic processGO:0060068.8INS, AKT1, NISCH, LEP
33positive regulation of insulin receptor signaling pathwayGO:0466288.7LEP, INS
34G-protein coupled receptor signaling pathwayGO:0071868.4AKT1, AGT, PTH, GNAI2, INS, AGTR1
35negative regulation of apoptotic processGO:0430668.0ALB, LEP, INS, EPO, AKT1

Molecular functions related to high blood pressure according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.7ACE, AGTR1
2acetyltransferase activator activityGO:0106989.5AGTR1, AGT
3peptide hormone receptor bindingGO:0514289.2PTH, LEP, NPPB
4hormone activityGO:0051797.4RETN, EPO, NPPB, AGT, EDN1, PTH
5protein bindingGO:0055155.1MAP2K1, COG2, LPL, EPO, ADRB3, ADORA2A

Sources for High Blood Pressure

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS