MCID: HGH001
MIFTS: 29

High Pressure Neurological Syndrome

Categories: Neuronal diseases

Aliases & Classifications for High Pressure Neurological Syndrome

MalaCards integrated aliases for High Pressure Neurological Syndrome:

Name: High Pressure Neurological Syndrome 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3230
MeSH 41 D006610
UMLS 69 C0019537

Summaries for High Pressure Neurological Syndrome

MalaCards based summary : High Pressure Neurological Syndrome is related to neuroblastoma and epilepsy, and has symptoms including hyperexplexia An important gene associated with High Pressure Neurological Syndrome is PGLYRP3 (Peptidoglycan Recognition Protein 3), and among its related pathways/superpathways are CREB Pathway and G-Beta Gamma Signaling. Affiliated tissues include brain, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for High Pressure Neurological Syndrome

Diseases related to High Pressure Neurological Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuroblastoma 9.7
2 epilepsy 9.7
3 streptococcal group a invasive disease 9.7
4 ocular dominance 9.6 GRIN1 HTR2C
5 mood disorder 9.3 CACNA1C HTR2C
6 bipolar disorder 9.1 CACNA1C GRIN1 HTR2C

Graphical network of the top 20 diseases related to High Pressure Neurological Syndrome:



Diseases related to High Pressure Neurological Syndrome

Symptoms & Phenotypes for High Pressure Neurological Syndrome

UMLS symptoms related to High Pressure Neurological Syndrome:


hyperexplexia

MGI Mouse Phenotypes related to High Pressure Neurological Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 CACNA1B CACNA1C CACNA1H GRIN1 HTR2C
2 cardiovascular system MP:0005385 9.35 CACNA1B CACNA1C CACNA1H GRIN1 PGLYRP3
3 nervous system MP:0003631 9.02 CACNA1B CACNA1C CACNA1H GRIN1 HTR2C

Drugs & Therapeutics for High Pressure Neurological Syndrome

Search Clinical Trials , NIH Clinical Center for High Pressure Neurological Syndrome

Cochrane evidence based reviews: high pressure neurological syndrome

Genetic Tests for High Pressure Neurological Syndrome

Anatomical Context for High Pressure Neurological Syndrome

MalaCards organs/tissues related to High Pressure Neurological Syndrome:

38
Brain

Publications for High Pressure Neurological Syndrome

Articles related to High Pressure Neurological Syndrome:

(show all 34)
# Title Authors Year
1
Acute combined pressure and temperature exposures on a shallow-water crustacean: novel insights into the stress response and high pressure neurological syndrome. ( 25433335 )
2015
2
Extremely deep recreational dives: the risk for carbon dioxide (CO(2)) retention and high pressure neurological syndrome (HPNS). ( 22669812 )
2012
3
Early morphological findings in experimental high pressure neurological syndrome. ( 9495642 )
1997
4
Effects of elevated pressures of inert gases on cytosolic free Ca2+ of cultured human neuroblastoma cells stimulated with carbachol: relevance to high pressure neurological syndrome. ( 8149411 )
1994
5
Possible NMDA antagonist properties of drugs that affect high pressure neurological syndrome. ( 7912632 )
1994
6
High-pressure neurological syndrome (HPNS). ( 7941956 )
1994
7
The orally active NMDA receptor antagonist CGP 39551 ameliorates the high pressure neurological syndrome in Papio anubis. ( 7902190 )
1993
8
Interactions of the beta carboline abecarnil with the high pressure neurological syndrome in a primate model. ( 1365651 )
1992
9
The high pressure neurological syndrome in genetically epilepsy prone rats: protective effect of 2-amino-7-phosphono heptanoate. ( 2029931 )
1991
10
The effects of the competitive NMDA receptor antagonist CPP on the high pressure neurological syndrome in a primate model. ( 1833661 )
1991
11
Brain nuclei and neurotransmitters involved in the regulation of the high pressure neurological syndrome in the rat. ( 1686303 )
1991
12
Effect of NMDA and 2-amino-7-phosphonoheptanoate focal injection into the ventrolateral thalamic nucleus on the high pressure neurological syndrome in the rat. ( 2159822 )
1990
13
The effects of MK801 on the high pressure neurological syndrome in the baboon (Papio anubis). ( 2255385 )
1990
14
Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats. ( 2556289 )
1989
15
The effects of kynurenic acid, quinolinic acid and other metabolites of tryptophan on the development of the high pressure neurological syndrome in the rat. ( 2927579 )
1989
16
Investigations into the origin of the high pressure neurological syndrome: the interaction between pressure, strychnine and 1,2-propandiols in the mouse. ( 3207974 )
1988
17
The effect of two novel dipeptide antagonists of excitatory amino acid neurotransmission on the high pressure neurological syndrome in the rat. ( 3040442 )
1987
18
Gamma-aminobutyric acid and the high pressure neurological syndrome. ( 3090469 )
1986
19
The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats. ( 6148724 )
1984
20
Effect of excitatory amino acid antagonists on the high pressure neurological syndrome in rats. ( 6096158 )
1984
21
Mechanistic studies on the high pressure neurological syndrome. ( 6142478 )
1984
22
Interactions of gamma-aminobutyric acid and noradrenaline in the high pressure neurological syndrome. ( 6652352 )
1983
23
2-Amino-phosphonoheptanoic acid protects against the high pressure neurological syndrome. ( 6406239 )
1983
24
Non-anesthetic steroids ameliorate the high pressure neurological syndrome in rats. ( 6843778 )
1983
25
Drugs that increase gamma-aminobutyric acid transmission protect against the high pressure neurological syndrome. ( 6286024 )
1982
26
The benzodiazepine antagonist, Ro 15-1788, prevents the effects of flurazepam on the high pressure neurological syndrome. ( 6815548 )
1982
27
Brain monoamines and the high pressure neurological syndrome. ( 6449674 )
1980
28
High pressure neurological syndrome: antagonistic effects of helium pressure and inhalation anesthetics on the dopamine-sensitive cyclic AMP response. ( 231338 )
1979
29
Stages in development of high-pressure neurological syndrome in the mouse. ( 457554 )
1979
30
Comparative physiology of the high-pressure neurological syndrome--compression rate effects. ( 110755 )
1979
31
Rate factors in development of the high-pressure neurological syndrome. ( 804465 )
1975
32
Intra- and interspecies variability of vertebrate high-pressure neurological syndrome. ( 4215787 )
1974
33
Inert gas narcosis, the high pressure neurological syndrome, and the critical volume hypothesis. ( 4843793 )
1974
34
N2, H2, and N2O antagonism of high pressure neurological syndrome in mice. ( 4469182 )
1974

Variations for High Pressure Neurological Syndrome

Expression for High Pressure Neurological Syndrome

Search GEO for disease gene expression data for High Pressure Neurological Syndrome.

Pathways for High Pressure Neurological Syndrome

Pathways related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 CACNA1B CACNA1C CACNA1H GRIN1 HTR2C
2
Show member pathways
12.63 CACNA1B CACNA1C CACNA1H HTR2C
3
Show member pathways
12.58 CACNA1B CACNA1C CACNA1H
4
Show member pathways
12.54 CACNA1B CACNA1C CACNA1H
5
Show member pathways
12.48 CACNA1B CACNA1C CACNA1H
6 12.44 CACNA1B CACNA1C CACNA1H
7
Show member pathways
12.29 CACNA1B CACNA1C CACNA1H GRIN1
8
Show member pathways
12.18 CACNA1B CACNA1C CACNA1H
9
Show member pathways
12.1 CACNA1B CACNA1C CACNA1H
10 12.04 CACNA1B CACNA1C GRIN1
11
Show member pathways
11.98 CACNA1B CACNA1C CACNA1H
12 11.76 CACNA1B CACNA1C CACNA1H
13
Show member pathways
11.72 CACNA1B CACNA1C
14
Show member pathways
11.69 CACNA1C GRIN1
15
Show member pathways
11.66 CACNA1B CACNA1C CACNA1H
16
Show member pathways
11.59 CACNA1B CACNA1C
17 11.49 CACNA1B CACNA1C HTR2C
18 11.34 CACNA1C CACNA1H
19
Show member pathways
11.29 CACNA1B CACNA1C CACNA1H GRIN1 HTR2C
20 11.27 CACNA1B CACNA1C
21 11.18 CACNA1B GRIN1
22 11.13 CACNA1C CACNA1H
23 11.09 CACNA1B CACNA1C CACNA1H
24 10.9 CACNA1B CACNA1C CACNA1H
25 10.86 CACNA1B CACNA1C
26 10.48 CACNA1B CACNA1C

GO Terms for High Pressure Neurological Syndrome

Cellular components related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated calcium channel complex GO:0005891 8.8 CACNA1B CACNA1C CACNA1H

Biological processes related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 transport GO:0006810 9.81 CACNA1B CACNA1C CACNA1H GRIN1
2 transmembrane transport GO:0055085 9.67 CACNA1B CACNA1C CACNA1H
3 ion transport GO:0006811 9.56 CACNA1B CACNA1C CACNA1H GRIN1
4 ion transmembrane transport GO:0034220 9.54 CACNA1C CACNA1H GRIN1
5 cellular calcium ion homeostasis GO:0006874 9.48 GRIN1 HTR2C
6 locomotory behavior GO:0007626 9.46 CACNA1B HTR2C
7 regulation of membrane potential GO:0042391 9.43 CACNA1H GRIN1
8 regulation of heart contraction GO:0008016 9.4 CACNA1B CACNA1H
9 calcium ion transmembrane transport GO:0070588 9.33 CACNA1B CACNA1C CACNA1H
10 membrane depolarization during action potential GO:0086010 9.32 CACNA1B CACNA1H
11 regulation of ion transmembrane transport GO:0034765 9.26 CACNA1B CACNA1C CACNA1H GRIN1
12 calcium ion transport GO:0006816 8.92 CACNA1B CACNA1C CACNA1H GRIN1

Molecular functions related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.43 CACNA1B CACNA1C CACNA1H
2 ion channel activity GO:0005216 9.33 CACNA1B CACNA1C GRIN1
3 high voltage-gated calcium channel activity GO:0008331 9.32 CACNA1B CACNA1C
4 voltage-gated calcium channel activity GO:0005245 9.13 CACNA1B CACNA1C CACNA1H
5 calcium channel activity GO:0005262 8.92 CACNA1B CACNA1C CACNA1H GRIN1

Sources for High Pressure Neurological Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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