MCID: HGH001
MIFTS: 33

High Pressure Neurological Syndrome

Categories: Neuronal diseases

Aliases & Classifications for High Pressure Neurological Syndrome

MalaCards integrated aliases for High Pressure Neurological Syndrome:

Name: High Pressure Neurological Syndrome 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3230
MeSH 42 D006610
UMLS 69 C0019537

Summaries for High Pressure Neurological Syndrome

MalaCards based summary : High Pressure Neurological Syndrome is related to neuroblastoma and epilepsy, and has symptoms including hyperexplexia An important gene associated with High Pressure Neurological Syndrome is PGLYRP3 (Peptidoglycan Recognition Protein 3), and among its related pathways/superpathways are CREB Pathway and TCR Signaling (Qiagen). The drugs Metformin and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and smooth muscle, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for High Pressure Neurological Syndrome

Diseases related to High Pressure Neurological Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 neuroblastoma 9.6
2 epilepsy 9.6
3 partial motor epilepsy 9.4 CACNA1C HTR2C
4 lipid pneumonia 7.2 CACNA1B CACNA1C CACNA1H GRIN1 HTR2C PGLYRP3

Symptoms & Phenotypes for High Pressure Neurological Syndrome

UMLS symptoms related to High Pressure Neurological Syndrome:


hyperexplexia

MGI Mouse Phenotypes related to High Pressure Neurological Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 CACNA1B CACNA1C CACNA1H GRIN1 HTR2C
2 cardiovascular system MP:0005385 9.35 CACNA1B CACNA1C CACNA1H GRIN1 PGLYRP3
3 nervous system MP:0003631 9.02 CACNA1B CACNA1C CACNA1H GRIN1 HTR2C

Drugs & Therapeutics for High Pressure Neurological Syndrome

Drugs for High Pressure Neurological Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
3
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
4 tannic acid Approved, Nutraceutical Phase 4
5 Antipsychotic Agents Phase 4,Phase 3
6 Central Nervous System Depressants Phase 4,Phase 3
7 Hypoglycemic Agents Phase 4
8 Psychotropic Drugs Phase 4,Phase 3
9 Tranquilizing Agents Phase 4,Phase 3
10 Dopamine Agents Phase 4,Phase 3,Phase 2
11 Dopamine agonists Phase 4,Phase 2
12 N 0437 Phase 4
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
14
Haloperidol Approved Phase 3 52-86-8 3559
15
Ziprasidone Approved Phase 3 146939-27-7 60854
16 4-des-dimethylaminotetracycline Phase 2, Phase 3
17 Antiemetics Phase 3
18 Autonomic Agents Phase 3
19 decanoic acid Phase 3
20 Dopamine Antagonists Phase 3
21 Gastrointestinal Agents Phase 3
22 Haloperidol decanoate Phase 3
23 Peripheral Nervous System Agents Phase 3
24
Serotonin Phase 3 50-67-9 5202
25 Serotonin Agents Phase 3
26 Serotonin Antagonists Phase 3
27
Pramipexole Approved, Investigational Phase 2 104632-26-0 59868 119570
28
Droxidopa Approved, Investigational Phase 2 23651-95-8 443940
29 Antibodies Phase 2
30 gamma-Globulins Phase 2
31 Immunoglobulins Phase 2
32 Immunoglobulins, Intravenous Phase 2
33 Pharmaceutical Solutions Phase 2
34 Rho(D) Immune Globulin Phase 2
35 Antioxidants Phase 2
36 Antiparkinson Agents Phase 2
37 Protective Agents Phase 2
38
Iron Approved 7439-89-6 23925
39
Acetylcholine Approved 51-84-3 187
40
Ephedrine Approved 299-42-3 9294
41
Isoproterenol Approved 7683-59-2 3779
42
Oxymetazoline Approved 1491-59-4 4636
43
Phenylephrine Approved 59-42-7 6041
44
Pseudoephedrine Approved 90-82-4 7028
45 Adrenergic beta-Antagonists
46 Antihypertensive Agents
47 calcium channel blockers
48 Calcium, Dietary
49 diuretics
50 Diuretics, Potassium Sparing

Interventional clinical trials:

(show all 41)

id Name Status NCT ID Phase Drugs
1 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
2 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome Unknown status NCT01823770 Phase 4 Rotigotine;Placebo patchs
3 Treadmill, Stretching and Proprioceptive Exercise (TreSPE) Rehabilitation Program for Charcot−Marie−Tooth Neuropathy Type 1A (CMT1A) Unknown status NCT01289704 Phase 2, Phase 3
4 Remote Ischemic Preconditioning in High Risk Cardiovascular Surgery Patients Completed NCT01328912 Phase 3
5 Liberal Oxygenation Versus Conservative Oxygenation in ARDS Recruiting NCT02713451 Phase 3 Modulation of Inspired Fraction of Oxygen (FiO2)
6 Efficacy of Transcatheter Ablation Using Anatomic Approach of Ganglionated Plexi Located in the Right Atrium to Prevent Neuromediated Cardioinhibitory Syncope Recruiting NCT01814228 Phase 3
7 The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA) Study Recruiting NCT01211522 Phase 3 Haloperidol;Ziprasidone;Placebo
8 Small Volume Plasma Exchange (SVPE) for Guillain-Barré Syndrome (GBS) Patients Completed NCT02780570 Phase 2
9 Study to Investigate Pharmacokinetics (PK) of Pramipexole in Pediatric Patients Who Are Individually Optimized to Stable Pramipexole Doses for the Treatment of Idiopathic Restless Legs Syndrome (RLS) Completed NCT02231918 Phase 2 MIRAPEX® - low;MIRAPEX® - medium;MIRAPEX® - high
10 Stroke and CPAP Outcome Study: A Sham-controlled Trial of CPAP Among Stroke Rehabilitation Patients Completed NCT02551757 Phase 1, Phase 2
11 The Effects of Aplindore on the Treatment of Signs and Symptoms of Restless Legs Syndrome Completed NCT00626418 Phase 2 Aplindore;Placebo
12 A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) Completed NCT02024789 Phase 2 Placebo;RG1662;RG1662
13 Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Vasovagal Syncope (VVS) Recruiting NCT02558972 Phase 2 Northera (Droxidopa);Placebo;Northera (Droxidopa);Placebo
14 Sleep Quality in Pregnancy and Its Impact on Pregnancy Outcomes Unknown status NCT02016638
15 Radial Extracorporeal Shock Wave Treatment (rESWT) of Myofascial Pain Syndrome in Low Back Pain Unknown status NCT01835795
16 Acute Care for Elders (ACE) Program at OHSU Hospital Unknown status NCT02119078
17 Assessment of Central Pain in the Peripartum Period Unknown status NCT01291680
18 The Effect of Vibration Therapy Over Neck Myofascial Trigger Points Unknown status NCT02393521
19 Effect of Increased Positive End-expiratory Pressure on Intracranial Pressure in Different Respiratory Mechanic in Acute Respiratory Distress Syndrome Completed NCT02670733
20 High Flow Nasal Canula Oxygen Helps Preoxygenate ARDS Patients Completed NCT02214576
21 Feasibility Evaluation of CPAP in the Treatment of Obstructive Sleep Apnea Synchrone in the Acute Phase of Stroke Completed NCT02522819
22 INtestinal Failure, multiPle Organ Failure ANd CItrulline Assessment Completed NCT02520440
23 The Effect of Intervention With Potassium and/ or Magnesium-enriched Salt on Neurological Performance of Stroke Patients Completed NCT02910427
24 Hypnosis in Autonomic Function Completed NCT00061009
25 Immediate Effects of a Spinal Lumbar Manipulation Completed NCT02312778
26 Systolic Blood Pressure Intervention Trial Completed NCT01206062
27 Effects of Milk Protein Concentrate on Overall Health During Weight Loss in Overweight/Obese Adults Completed NCT01692860
28 Is Non-Cardiac Chest Pain Caused by Sustained Longitudinal Smooth Muscle Contraction? Completed NCT01839058
29 Tilt Table With Suspected Postural Orthostatic Tachycardia Syndrome (POTS) Subjects Completed NCT01617616
30 Thoracic Ultrasonography for Pulmonary Edema in Patients With Pre-Eclampsia Completed NCT02357264
31 Evaluation of a Simplified Method for Diagnosis of Sleep Apnea in Children and Adults With Down Syndrome Completed NCT00951730
32 Effect of CPAP on Postoperative Delirium Completed NCT01816685
33 Sleep Disorders Managed and Assessed Rapidly in Transient Ischemic Attack (TIA) and In Early Stroke Completed NCT01528462
34 Autoimmune Basis for Postural Tachycardia Syndrome Recruiting NCT02725060 phenylephrine;isoproterenol
35 A Pilot Study to Evaluate the Safety and Efficacy of the Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Obstructive Sleep Apnea Recruiting NCT02344108
36 Essential Hypotension and Allostasis Registry Recruiting NCT02018497
37 Telemedicine Monitoring of Sleep Apnea in Stroke Active, not recruiting NCT02748681
38 Analysis of Sympathetic Activity in Willis-Ekbom Disease Not yet recruiting NCT02929732
39 Brain Network Activation in Patients With Movement Disorders Not yet recruiting NCT03269201
40 Correlation Between Optic Nerve Vessel Anomalies, Serum Angiogenic Factors and Renal Anomalies in Down Syndrome Children Not yet recruiting NCT03206957
41 The Natural History of Reproductive and Overall Health in Girls and Women With a Pre-Mutation in the FMR1 Gene; Creation of a Patient Registry Terminated NCT01187524

Search NIH Clinical Center for High Pressure Neurological Syndrome

Cochrane evidence based reviews: high pressure neurological syndrome

Genetic Tests for High Pressure Neurological Syndrome

Anatomical Context for High Pressure Neurological Syndrome

MalaCards organs/tissues related to High Pressure Neurological Syndrome:

39
Brain, Endothelial, Smooth Muscle

Publications for High Pressure Neurological Syndrome

Articles related to High Pressure Neurological Syndrome:

(show all 34)
id Title Authors Year
1
Acute combined pressure and temperature exposures on a shallow-water crustacean: novel insights into the stress response and high pressure neurological syndrome. ( 25433335 )
2015
2
Extremely deep recreational dives: the risk for carbon dioxide (CO(2)) retention and high pressure neurological syndrome (HPNS). ( 22669812 )
2012
3
Early morphological findings in experimental high pressure neurological syndrome. ( 9495642 )
1997
4
High-pressure neurological syndrome (HPNS). ( 7941956 )
1994
5
Possible NMDA antagonist properties of drugs that affect high pressure neurological syndrome. ( 7912632 )
1994
6
Effects of elevated pressures of inert gases on cytosolic free Ca2+ of cultured human neuroblastoma cells stimulated with carbachol: relevance to high pressure neurological syndrome. ( 8149411 )
1994
7
The orally active NMDA receptor antagonist CGP 39551 ameliorates the high pressure neurological syndrome in Papio anubis. ( 7902190 )
1993
8
Interactions of the beta carboline abecarnil with the high pressure neurological syndrome in a primate model. ( 1365651 )
1992
9
The effects of the competitive NMDA receptor antagonist CPP on the high pressure neurological syndrome in a primate model. ( 1833661 )
1991
10
The high pressure neurological syndrome in genetically epilepsy prone rats: protective effect of 2-amino-7-phosphono heptanoate. ( 2029931 )
1991
11
Brain nuclei and neurotransmitters involved in the regulation of the high pressure neurological syndrome in the rat. ( 1686303 )
1991
12
The effects of MK801 on the high pressure neurological syndrome in the baboon (Papio anubis). ( 2255385 )
1990
13
Effect of NMDA and 2-amino-7-phosphonoheptanoate focal injection into the ventrolateral thalamic nucleus on the high pressure neurological syndrome in the rat. ( 2159822 )
1990
14
Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats. ( 2556289 )
1989
15
The effects of kynurenic acid, quinolinic acid and other metabolites of tryptophan on the development of the high pressure neurological syndrome in the rat. ( 2927579 )
1989
16
Investigations into the origin of the high pressure neurological syndrome: the interaction between pressure, strychnine and 1,2-propandiols in the mouse. ( 3207974 )
1988
17
The effect of two novel dipeptide antagonists of excitatory amino acid neurotransmission on the high pressure neurological syndrome in the rat. ( 3040442 )
1987
18
Gamma-aminobutyric acid and the high pressure neurological syndrome. ( 3090469 )
1986
19
Effect of excitatory amino acid antagonists on the high pressure neurological syndrome in rats. ( 6096158 )
1984
20
The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats. ( 6148724 )
1984
21
Mechanistic studies on the high pressure neurological syndrome. ( 6142478 )
1984
22
Non-anesthetic steroids ameliorate the high pressure neurological syndrome in rats. ( 6843778 )
1983
23
Interactions of gamma-aminobutyric acid and noradrenaline in the high pressure neurological syndrome. ( 6652352 )
1983
24
2-Amino-phosphonoheptanoic acid protects against the high pressure neurological syndrome. ( 6406239 )
1983
25
The benzodiazepine antagonist, Ro 15-1788, prevents the effects of flurazepam on the high pressure neurological syndrome. ( 6815548 )
1982
26
Drugs that increase gamma-aminobutyric acid transmission protect against the high pressure neurological syndrome. ( 6286024 )
1982
27
Brain monoamines and the high pressure neurological syndrome. ( 6449674 )
1980
28
Stages in development of high-pressure neurological syndrome in the mouse. ( 457554 )
1979
29
High pressure neurological syndrome: antagonistic effects of helium pressure and inhalation anesthetics on the dopamine-sensitive cyclic AMP response. ( 231338 )
1979
30
Comparative physiology of the high-pressure neurological syndrome--compression rate effects. ( 110755 )
1979
31
Rate factors in development of the high-pressure neurological syndrome. ( 804465 )
1975
32
Inert gas narcosis, the high pressure neurological syndrome, and the critical volume hypothesis. ( 4843793 )
1974
33
N2, H2, and N2O antagonism of high pressure neurological syndrome in mice. ( 4469182 )
1974
34
Intra- and interspecies variability of vertebrate high-pressure neurological syndrome. ( 4215787 )
1974

Variations for High Pressure Neurological Syndrome

Expression for High Pressure Neurological Syndrome

Search GEO for disease gene expression data for High Pressure Neurological Syndrome.

Pathways for High Pressure Neurological Syndrome

Pathways related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

(show all 25)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 CACNA1B CACNA1C CACNA1H GRIN1 HTR2C
2
Show member pathways
12.57 CACNA1B CACNA1C CACNA1H
3
Show member pathways
12.54 CACNA1B CACNA1C CACNA1H
4
Show member pathways
12.52 CACNA1B CACNA1C CACNA1H
5
Show member pathways
12.51 CACNA1B CACNA1C CACNA1H
6 12.38 CACNA1B CACNA1C CACNA1H
7
Show member pathways
12.29 CACNA1B CACNA1C CACNA1H GRIN1
8
Show member pathways
12.09 CACNA1B CACNA1C CACNA1H
9 12.03 CACNA1B CACNA1C GRIN1
10
Show member pathways
11.96 CACNA1B CACNA1C CACNA1H
11 11.76 CACNA1B CACNA1C CACNA1H
12
Show member pathways
11.72 CACNA1B CACNA1C
13
Show member pathways
11.68 CACNA1C GRIN1
14
Show member pathways
11.66 CACNA1B CACNA1C CACNA1H
15
Show member pathways
11.57 CACNA1B CACNA1C
16 11.49 CACNA1B CACNA1C HTR2C
17 11.41 CACNA1B CACNA1C CACNA1H
18 11.32 CACNA1C CACNA1H
19
Show member pathways
11.29 CACNA1B CACNA1C CACNA1H GRIN1 HTR2C
20 11.25 CACNA1B CACNA1C
21 11.14 CACNA1B GRIN1
22 11.09 CACNA1C CACNA1H
23 10.9 CACNA1B CACNA1C CACNA1H
24 10.84 CACNA1B CACNA1C
25 10.48 CACNA1B CACNA1C

GO Terms for High Pressure Neurological Syndrome

Cellular components related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated calcium channel complex GO:0005891 8.8 CACNA1B CACNA1C CACNA1H

Biological processes related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.65 CACNA1B CACNA1C CACNA1H
2 ion transport GO:0006811 9.56 CACNA1B CACNA1C CACNA1H GRIN1
3 cellular calcium ion homeostasis GO:0006874 9.46 GRIN1 HTR2C
4 regulation of ion transmembrane transport GO:0034765 9.46 CACNA1B CACNA1C CACNA1H GRIN1
5 locomotory behavior GO:0007626 9.43 CACNA1B HTR2C
6 regulation of membrane potential GO:0042391 9.4 CACNA1H GRIN1
7 regulation of heart contraction GO:0008016 9.37 CACNA1B CACNA1H
8 membrane depolarization during action potential GO:0086010 9.32 CACNA1B CACNA1H
9 calcium ion transport GO:0006816 9.26 CACNA1B CACNA1C CACNA1H GRIN1
10 calcium ion transmembrane transport GO:0070588 8.92 CACNA1B CACNA1C CACNA1H GRIN1

Molecular functions related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.43 CACNA1B CACNA1C CACNA1H
2 ion channel activity GO:0005216 9.33 CACNA1B CACNA1C GRIN1
3 high voltage-gated calcium channel activity GO:0008331 9.32 CACNA1B CACNA1C
4 voltage-gated calcium channel activity GO:0005245 9.13 CACNA1B CACNA1C CACNA1H
5 calcium channel activity GO:0005262 8.92 CACNA1B CACNA1C CACNA1H GRIN1

Sources for High Pressure Neurological Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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