MCID: HST016
MIFTS: 41

Histiocytic Sarcoma malady

Categories: Cancer diseases, Blood diseases, Rare diseases

Aliases & Classifications for Histiocytic Sarcoma

Aliases & Descriptions for Histiocytic Sarcoma:

Name: Histiocytic Sarcoma 56 69

Characteristics:

Orphanet epidemiological data:

56
histiocytic sarcoma
Age of onset: Adult;

Classifications:



External Ids:

Orphanet 56 ORPHA86896
MESH via Orphanet 43 D054747
UMLS via Orphanet 70 C0334663
ICD10 via Orphanet 34 C96.8
ICD10 33 C96.8

Summaries for Histiocytic Sarcoma

MalaCards based summary : Histiocytic Sarcoma is related to malignant histiocytosis and reticulosarcoma. An important gene associated with Histiocytic Sarcoma is CD163 (CD163 Molecule), and among its related pathways/superpathways are Innate Immune System and Immune response Lectin induced complement pathway. The drugs Lenalidomide and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and spleen, and related phenotypes are cellular and hematopoietic system

Wikipedia : 71 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

Related Diseases for Histiocytic Sarcoma

Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 malignant histiocytosis 11.4
2 reticulosarcoma 10.9
3 sarcoma 10.8
4 lucey-driscoll syndrome 10.3 MUC1 S100B
5 secondary pulmonary hemosiderosis 10.3 MUC1 S100B
6 lupus - neurological sequelae 10.3 PTEN S100B
7 myelinoclastic diffuse sclerosis 10.3 MUC1 S100B
8 invasive mole 10.3 MUC1 S100B
9 bronchial mucus gland adenoma 10.3 PTEN S100B
10 myoma 10.3 MUC1 S100B
11 pemphigus vegetans 10.3 MUC1 S100B
12 spleen angiosarcoma 10.3 MUC1 S100B
13 immunodeficiency due to a classical component pathway complement deficiency 10.3 CDKN2A MUC1
14 ovarian cystadenoma 10.3 MUC1 S100B
15 trombiculiasis 10.3 MUC1 S100B
16 aneurysm of sinus of valsalva 10.2 MUC1 PTEN S100B
17 lower clivus meningioma 10.2 CR1 CR2
18 mediastinum liposarcoma 10.2 CDKN2A MUC1 S100B
19 polydactyly cleft lip palate psychomotor retardation 10.2 CDKN2A MS4A1 MUC1
20 pathologic nystagmus 10.2 CDKN2A MUC1 S100B
21 spondylarthropathy 10.2 BRAF CDKN2A
22 lymphoma 10.2
23 alezzandrini syndrome 10.2 LGALS3 MS4A1
24 postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 10.2 MUC1 S100B
25 biliary papillomatosis 10.2 BRAF MUC1 S100B
26 occlusion precerebral artery 10.2 CDKN2A MUC1 S100B
27 cutis laxa 10.2 CD163 CSF1 CSF1R
28 leukemia 10.2
29 autosomal recessive stickler syndrome 10.2 BRAF MUC1
30 mite infestation 10.2 CD163 CR1 CR2
31 trachea squamous cell carcinoma 10.2 CDKN2A MUC1 PTEN
32 microinvasive cervical squamous cell carcinoma 10.2 MUC1 S100B
33 acute disseminated encephalomyelitis 10.2 BRAF CDKN2A PTEN
34 adenosquamous colon carcinoma 10.2 CD163 CR1 CR2
35 cavernous sinus meningioma 10.2 CD163 FSCN1 S100B
36 popliteal pterygium syndrome, bartsocas-papas type 10.2 LGALS3 MUC1 S100B
37 chiasmal syndrome 10.2 CD68 S100B
38 heart sarcoma 10.2 CD68 CDKN2A
39 omodysplasia 2 10.2 CR1 CR2 MUC1
40 cecum adenoma 10.1 CR1 CR2 S100B
41 intestinal benign neoplasm 10.1 LGALS3 MUC1 PTEN
42 demyelinating disease 10.1 CD68 PTEN
43 ulnar neuropathy 10.1 CD163 CD68 PTEN
44 glomeruloid hemangioma 10.1 BRAF CDKN2A PTEN
45 bilateral breast cancer 10.1 CD163 CD68 CR2
46 teeth hard tissue disease 10.1 CD163 CD68
47 dentin dysplasia with sclerotic bones 10.1 BRAF CD163 CSF1 S100B
48 cloacogenic carcinoma 10.1 CR1 CR2
49 episodic ataxia 10.1 CD68 CDKN2A MUC1
50 lymphoblastic leukemia 10.1

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to Histiocytic Sarcoma

Symptoms & Phenotypes for Histiocytic Sarcoma

MGI Mouse Phenotypes related to Histiocytic Sarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 LGALS3 BRAF PTEN CD163 TIMD4 CDKN2A
2 hematopoietic system MP:0005397 9.73 MS4A1 BRAF PTEN CD163 TIMD4 CD68
3 immune system MP:0005387 9.44 MS4A1 BRAF PTEN CD163 TIMD4 CD68

Drugs & Therapeutics for Histiocytic Sarcoma

Drugs for Histiocytic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenalidomide Approved Phase 2 191732-72-6 216326
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3
Everolimus Approved Phase 2 159351-69-6 6442177
4
Olaparib Approved Phase 2 763113-22-0 23725625
5
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
6 Anti-Infective Agents Phase 2
7 Angiogenesis Inhibitors Phase 2
8 Angiogenesis Modulating Agents Phase 2
9 Anti-Bacterial Agents Phase 2
10 Immunosuppressive Agents Phase 2
11 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
12 Antifungal Agents Phase 2
13 Antibiotics, Antitubercular Phase 2
14
Zidovudine Approved 30516-87-1 35370
15 Nucleic Acid Synthesis Inhibitors
16 Anti-HIV Agents
17 Antimetabolites
18 Anti-Retroviral Agents
19 Reverse Transcriptase Inhibitors
20 Antiviral Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Study of Lenalidomide for Adult Histiocyte Disorders Recruiting NCT02523040 Phase 2
2 Pediatric MATCH: Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Advanced Refractory Solid Tumors or Lymphomas Not yet recruiting NCT03155620 Phase 2
3 A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow Transplant Completed NCT00002284

Search NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

Anatomical Context for Histiocytic Sarcoma

MalaCards organs/tissues related to Histiocytic Sarcoma:

39
Brain, Thyroid, Spleen, B Cells, Bone Marrow, Lymph Node, Bone

Publications for Histiocytic Sarcoma

Articles related to Histiocytic Sarcoma:

(show top 50) (show all 265)
id Title Authors Year
1
Dermoscopic characteristics of a cutaneous histiocytic sarcoma in a young patient. ( 28087030 )
2017
2
Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation. ( 27429816 )
2016
3
Histological and immunohistochemical features of histiocytic sarcoma in four domestic ferrets (Mustela putorius furo). ( 26965237 )
2016
4
Risk Factors Associated with Development of Histiocytic Sarcoma in Bernese Mountain Dogs. ( 27160025 )
2016
5
Evaluation of Costimulatory Molecules in Peripheral Blood Lymphocytes of Canine Patients with Histiocytic Sarcoma. ( 26901565 )
2016
6
A rare case of paediatric histiocytic sarcoma of the maxilla and mandible. ( 27090951 )
2016
7
Hepatic Involvement of Histiocytic Sarcoma: CT and MRI Findings. ( 27587965 )
2016
8
Histiocytic sarcoma: secondary neoplasm or "transdifferentiation" in the setting of B-acute lymphoblastic leukemia. ( 27856472 )
2016
9
High-dose methotrexate-based chemotherapy as treatment for histiocytic sarcoma of the central nervous system. ( 26727454 )
2016
10
SYSTEMIC HISTIOCYTIC SARCOMA IN A COMMON HIPPOPOTAMUS (HIPPOPOTAMUS AMPHIBIUS). ( 27468044 )
2016
11
Disseminated histiocytic sarcoma in a child: a clinicopathological dichotomy with 8a88years survival. ( 27190112 )
2016
12
Cooperation of BRAF(F595L) and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling. ( 26582644 )
2016
13
Clinical prognostic factors in canine histiocytic sarcoma. ( 27334037 )
2016
14
Primary Orbital Histiocytic Sarcoma in a Child Successfully Treated With Multiagent Chemotherapy. ( 27467374 )
2016
15
An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. ( 27325388 )
2016
16
NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-I_B signaling. ( 27105514 )
2016
17
Cutaneous Histiocytic Sarcoma with Regional Lymph Node Metastasis in a Netherland Dwarf Rabbit (Oryctolagus cuniculus). ( 27890406 )
2016
18
Microglioma in a child - a further case in support of the microglioma entity and distinction from histiocytic sarcoma. ( 27191913 )
2016
19
Gastric histiocytic sarcoma in a dog. ( 27925661 )
2016
20
Reduced angiogenic gene expression in morbillivirus-triggered oncolysis in a translational model for histiocytic sarcoma. ( 27860224 )
2016
21
Histiocytic Sarcoma as a Secondary Malignancy: Pathobiology, Diagnosis, and Treatment. ( 26990812 )
2016
22
Long-term treatment with the oncolytic ECHO-7 virus Rigvir of a melanoma stage IV M1c patient, a small cell lung cancer stage IIIA patient, and a histiocytic sarcoma stage IV patient-three case reports. ( 27457663 )
2016
23
Apoptosis inhibitor of macrophage (AIM) reduces cell number in canine histiocytic sarcoma cell lines. ( 27246397 )
2016
24
Persistent Morbillivirus Infection Leads to Altered Cortactin Distribution in Histiocytic Sarcoma Cells with Decreased Cellular Migration Capacity. ( 27911942 )
2016
25
Two cases of histiocytic sarcoma with BCL2 translocations and occult or subsequent follicular lymphoma. ( 27134111 )
2016
26
Somatic mutations in histiocytic sarcoma identified by next generation sequencing. ( 27259537 )
2016
27
Circulating let-7g is down-regulated in Bernese Mountain dogs with disseminated histiocytic sarcoma and carcinomasA -A a prospective study. ( 26792388 )
2016
28
Diffuse Histiocytic Sarcoma Involving the Choroid. ( 27541306 )
2016
29
Primary histiocytic sarcoma of the uterine cervix: an extremely rare entity. ( 27828780 )
2016
30
Histiocytic Sarcoma in a Kidney Transplant Patient: A Case Report and Review of the Literature. ( 27795864 )
2016
31
Comparison of conventional magnetic resonance imaging and nonenhanced three dimensional time-of-flight magnetic resonance angiography findings between dogs with meningioma and dogs with intracranial histiocytic sarcoma: 19 cases (2010-2014). ( 27135670 )
2016
32
Disseminated Histiocytic Sarcoma in an African Hedgehog (Atelerix albiventris). ( 27720131 )
2016
33
Sudden unexpected death from an undiagnosed histiocytic sarcoma in an adolescent female. ( 27465385 )
2016
34
Diffuse leptomeningeal histiocytic sarcoma in the cerebrospinal fluid of 2 dogs. ( 26882507 )
2016
35
A 43-Year-Old Female with Multifocal Cerebral Lesions. Histiocytic Sarcoma. ( 26086057 )
2015
36
Post mortem computed tomography and core needle biopsy in comparison to autopsy in eleven Bernese mountain dogs with histiocytic sarcoma. ( 26329821 )
2015
37
Flow cytometry used to identify histiocytic sarcoma: A case report. ( 26082038 )
2015
38
A Case of G-CSF-Producing Histiocytic Sarcoma of the Stomach. ( 25785346 )
2015
39
Histiocytic Sarcoma and Bilateral Facial Vein Thrombosis in a Siberian Hamster (Phodopus sungorus). ( 25926398 )
2015
40
Cutaneous histiocytic sarcoma with E-cadherin expression in a Pembroke Welsh Corgi dog. ( 26330395 )
2015
41
Histiocytic Sarcoma Originating in the Lung in a 16-Year-Old Male. ( 26106007 )
2015
42
Pathology in Practice. Histiocytic sarcoma. ( 26133215 )
2015
43
Influence of a survivin suppressor YM155 on the chemoresistance of canine histiocytic sarcoma cells. ( 26048444 )
2015
44
Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma. ( 25828786 )
2015
45
Sub-cutaneous histiocytic sarcoma in a child: a case report. ( 26757497 )
2015
46
Fine needle aspiration cytology of histiocytic sarcoma with dendritic cell differentiation: a case of transdifferentiation from low-grade follicular lymphoma. ( 25993973 )
2015
47
Coexistence of tuberculosis with histiocytic sarcoma: A rare association. ( 26458659 )
2015
48
Histiocytic sarcoma; case report of a rare disease in a kidney transplant recipient. ( 26312238 )
2015
49
An unusual case of histiocytic sarcoma. ( 27509705 )
2015
50
Concomitant follicular lymphoma and histiocytic sarcoma: A rare progression, trans-differentiation or co-occurrence? ( 26549087 )
2015

Variations for Histiocytic Sarcoma

Expression for Histiocytic Sarcoma

Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for Histiocytic Sarcoma

GO Terms for Histiocytic Sarcoma

Cellular components related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.7 BRAF CD163 CD68 CR1 CR2 CSF1
2 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.8 CSF1 CSF1R FSCN1 PTEN S100B
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 BRAF CSF1R HAVCR2 PTEN
3 long-term synaptic potentiation GO:0060291 9.54 BRAF PTEN S100B
4 macrophage differentiation GO:0030225 9.49 CSF1 CSF1R
5 complement receptor mediated signaling pathway GO:0002430 9.48 CR1 CR2
6 regulation of axon regeneration GO:0048679 9.46 BRAF PTEN
7 immune system process GO:0002376 9.43 CR1 CR2 CSF1 CSF1R HAVCR2 LGALS3
8 macrophage colony-stimulating factor signaling pathway GO:0038145 9.32 CSF1 CSF1R
9 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189 9.26 HAVCR2 LGALS3
10 innate immune response GO:0045087 9.17 CR1 CR2 CSF1 CSF1R HAVCR2 LGALS3
11 negative regulation of immunological synapse formation GO:2000521 9.16 HAVCR2 LGALS3

Sources for Histiocytic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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