MCID: HST016
MIFTS: 42

Histiocytic Sarcoma

Categories: Cancer diseases, Blood diseases, Rare diseases

Aliases & Classifications for Histiocytic Sarcoma

MalaCards integrated aliases for Histiocytic Sarcoma:

Name: Histiocytic Sarcoma 56 69

Characteristics:

Orphanet epidemiological data:

56
histiocytic sarcoma
Age of onset: Adult;

Classifications:



External Ids:

Orphanet 56 ORPHA86896
MESH via Orphanet 43 D054747
UMLS via Orphanet 70 C0334663
ICD10 via Orphanet 34 C96.8
ICD10 33 C96.8

Summaries for Histiocytic Sarcoma

MalaCards based summary : Histiocytic Sarcoma is related to tropical spastic paraparesis and autoimmune lymphoproliferative syndrome. An important gene associated with Histiocytic Sarcoma is CD163 (CD163 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and bone, and related phenotypes are hematopoietic system and cellular

Wikipedia : 72 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

Related Diseases for Histiocytic Sarcoma

Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
id Related Disease Score Top Affiliating Genes
1 tropical spastic paraparesis 30.1 CD68 PTEN
2 autoimmune lymphoproliferative syndrome 29.5 CD68 MUC1 PTEN S100B
3 malignant histiocytosis 11.3
4 sarcoma 10.9
5 2q31.1 microdeletion syndrome 10.8 BRAF MUC1
6 logopenic progressive aphasia 10.8 MUC1 S100B
7 heiner syndrome 10.8 MUC1 S100B
8 meningitis and encephalitis 10.8 MUC1 S100B
9 dedifferentiated liposarcoma 10.8 MUC1 S100B
10 simple cryoglobulinemia 10.8 MUC1 S100B
11 immune-mediated encephalomyelitis 10.8 PTEN S100B
12 spleen angiosarcoma 10.8 MUC1 S100B
13 myoma 10.8 MUC1 S100B
14 mucinous ovarian cystadenoma 10.7 MUC1 S100B
15 juvenile nasopharyngeal angiofibroma 10.7 BRAF S100B
16 enteric pattern testicular yolk sac tumor 10.7 MUC1 S100B
17 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.7 CDKN2A MUC1
18 ovarian mucinous cystadenofibroma 10.7 PTEN S100B
19 laryngeal neuroendocrine tumor 10.7 BRAF MUC1
20 noninvasive malignant thymoma 10.7 MUC1 S100B
21 reticular pattern testicular yolk sac tumor 10.7 MUC1 S100B
22 pancreatic intraductal papillary-colloid carcinoma 10.7 MUC1 S100B
23 invasive malignant thymoma 10.7 PTEN S100B
24 split hand split foot nystagmus 10.6 BRAF CDKN2A
25 polyosteolysis/hyperostosis syndrome 10.6 LGALS3 MUC1 S100B
26 lice infestation 10.6 MUC1 S100B
27 gastric papillary adenocarcinoma 10.6 MUC1 S100B
28 central breast papilloma 10.6 CR1 CR2
29 urethral urothelial papilloma 10.6 CD163 CD68
30 chronic neutrophilic leukemia 10.6 CDKN2A LGALS3 MUC1
31 gastrointestinal system cancer 10.6 BRAF LGALS3 MUC1
32 anaplastic oligodendroglioma 10.6 MUC1 PTEN S100B
33 bladder colloid adenocarcinoma 10.6 CDKN2A MUC1
34 teeth hard tissue disease 10.5 CD163 CD68
35 plummer vinson syndrome 10.5 CDKN2A MS4A1 MUC1
36 pleural empyema 10.5 MUC1 S100B
37 lymphangiosarcoma 10.5 BRAF MUC1
38 testicular spermatocytic seminoma 10.5 CD163 CD68
39 ganglioglioma 10.5 MUC1 S100B
40 chorea, hereditary benign 10.5 BRAF LGALS3 PTEN
41 common bile duct neoplasm 10.5 CD163 CD68
42 localized pulmonary fibrosis 10.5 CD68 S100B
43 spindle cell liposarcoma 10.5 CDKN2A MUC1 S100B
44 diffuse meningeal melanocytosis 10.5 CDKN2A MUC1 PTEN
45 kidney hypertrophy 10.5 CDKN2A MUC1 S100B
46 rectum leiomyoma 10.5 CR1 CR2
47 trachea squamous cell carcinoma 10.5 CDKN2A MUC1 PTEN
48 frontotemporal dementia and/or amyotrophic lateral sclerosis 4 10.4 BRAF LGALS3 PTEN
49 bladder urachal squamous cell carcinoma 10.4 CDKN2A MUC1 S100B
50 brown-vialetto-van laere syndrome 10.4 CDKN2A MUC1 PTEN

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to Histiocytic Sarcoma

Symptoms & Phenotypes for Histiocytic Sarcoma

MGI Mouse Phenotypes related to Histiocytic Sarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 PTEN CDKN2A CR2 TIMD4 CSF1 CSF1R
2 cellular MP:0005384 10.06 PTEN CDKN2A TIMD4 CSF1 CSF1R BCL2
3 immune system MP:0005387 10 CDKN2A CR2 TIMD4 CSF1 CSF1R BCL2
4 integument MP:0010771 9.56 PTEN CDKN2A S100B CSF1 CSF1R BCL2
5 respiratory system MP:0005388 9.1 PTEN CDKN2A CSF1 BCL2 BRAF LGALS3

Drugs & Therapeutics for Histiocytic Sarcoma

Drugs for Histiocytic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Lenalidomide Approved Phase 2 191732-72-6 216326
4
Olaparib Approved Phase 2 763113-22-0 23725625
5
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
6 Anti-Infective Agents Phase 2
7 Angiogenesis Inhibitors Phase 2
8 Angiogenesis Modulating Agents Phase 2
9 Anti-Bacterial Agents Phase 2
10 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
11 Immunosuppressive Agents Phase 2
12 Antifungal Agents Phase 2
13 Antibiotics, Antitubercular Phase 2
14 tyrosine Nutraceutical Phase 2
15
Zidovudine Approved 30516-87-1 35370
16 Reverse Transcriptase Inhibitors
17 Nucleic Acid Synthesis Inhibitors
18 Anti-HIV Agents
19 Anti-Retroviral Agents
20 Antimetabolites
21 Antiviral Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Study of Lenalidomide for Adult Histiocyte Disorders Recruiting NCT02523040 Phase 2 Lenalidomide
2 Pediatric MATCH: Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders Recruiting NCT03155620 Phase 2 Ensartinib;Erdafitinib;Larotrectinib;Olaparib;PI3K/mTOR Inhibitor LY3023414;Selumetinib Sulfate;Tazemetostat;Vemurafenib
3 Pediatric MATCH: Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations Recruiting NCT03213665 Phase 2 Tazemetostat
4 Pediatric MATCH: Trk Inhibitor LOXO-101 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions Recruiting NCT03213704 Phase 2 Larotrectinib
5 Pediatric MATCH: PI3K/mTOR Inhibitor LY3023414 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations Recruiting NCT03213678 Phase 2 PI3K/mTOR Inhibitor LY3023414
6 Pediatric MATCH: Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations Recruiting NCT03220035 Phase 2 Vemurafenib
7 Pediatric MATCH: Pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations Not yet recruiting NCT03210714 Phase 2 Erdafitinib
8 A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow Transplant Completed NCT00002284 Zidovudine

Search NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

Anatomical Context for Histiocytic Sarcoma

MalaCards organs/tissues related to Histiocytic Sarcoma:

39
Brain, Thyroid, Bone, Bone Marrow, B Cells, Spleen, Testes

Publications for Histiocytic Sarcoma

Articles related to Histiocytic Sarcoma:

(show top 50) (show all 284)
id Title Authors Year
1
Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. ( 28621004 )
2017
2
Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics. ( 28805986 )
2017
3
BRAF (V600E) expression in histiocytic sarcoma associated with splenic marginal zone lymphoma: a case report. ( 28376906 )
2017
4
Effect of dasatinib in a xenograft mouse model of canine histiocytic sarcoma and in vitro expression status of its potential target EPHA2. ( 28833247 )
2017
5
Comparisons among MRI signs, apparent diffusion coefficient, and fractional anisotropy in dogs with a solitary intracranial meningioma or histiocytic sarcoma. ( 28335080 )
2017
6
Disseminated histiocytic sarcoma with hemophagocytosis in a rabbit. ( 28740033 )
2017
7
Efficacy of dacarbazine as a rescue agent for histiocytic sarcoma in dogs. ( 28419676 )
2017
8
Successful treatment of histiocytic sarcoma with cladribine and high-dose cytosine arabinoside in a child. ( 28247189 )
2017
9
Canine histiocytic sarcoma presenting as a target lesion on brain magnetic resonance imaging and as a solitary pulmonary mass. ( 28419635 )
2017
10
Infection or Glioma? The False Dilemma of Primary Central Nervous System Histiocytic Sarcoma. ( 28711535 )
2017
11
Pediatric intracerebral histiocytic sarcoma with rhabdoid features: Case report and literature review. ( 28748542 )
2017
12
Syndrome of inappropriate antidiuretic hormone secretion in a dog with a histiocytic sarcoma. ( 28698689 )
2017
13
Dermoscopic characteristics of a cutaneous histiocytic sarcoma in a young patient. ( 28087030 )
2017
14
Histiocytic sarcoma in 14 miniature schnauzers - a new breed predisposition? ( 28543363 )
2017
15
Invasive histiocytic sarcoma of the lumbar spine in a ferret (Mustela putorius furo). ( 28160308 )
2017
16
Atypical cytologic presentation of a histiocytic sarcoma in a Cavalier King Charles Spaniel dog. ( 28381106 )
2017
17
A 2-base insertion in exon 5 is a common mutation of the TP53 gene in dogs with histiocytic sarcoma. ( 28867679 )
2017
18
Retroperitoneal Bulky Histiocytic Sarcoma Successfully Treated with Induction Chemotherapy Followed by Curative Surgery. ( 28924109 )
2017
19
Prior joint disease is associated with increased risk of periarticular histiocytic sarcoma in dogs. ( 28836371 )
2017
20
Primary histiocytic sarcoma presenting as diffuse leptomeningeal disease: Case description and review of the literature. ( 28548244 )
2017
21
Diffuse leptomeningeal histiocytic sarcoma in the cerebrospinal fluid of 2 dogs. ( 26882507 )
2016
22
Apoptosis inhibitor of macrophage (AIM) reduces cell number in canine histiocytic sarcoma cell lines. ( 27246397 )
2016
23
Sudden unexpected death from an undiagnosed histiocytic sarcoma in an adolescent female. ( 27465385 )
2016
24
Histiocytic Sarcoma in a Kidney Transplant Patient: A Case Report and Review of the Literature. ( 27795864 )
2016
25
A rare case of paediatric histiocytic sarcoma of the maxilla and mandible. ( 27090951 )
2016
26
SYSTEMIC HISTIOCYTIC SARCOMA IN A COMMON HIPPOPOTAMUS (HIPPOPOTAMUS AMPHIBIUS). ( 27468044 )
2016
27
Reduced angiogenic gene expression in morbillivirus-triggered oncolysis in a translational model for histiocytic sarcoma. ( 27860224 )
2016
28
Histiocytic sarcoma: secondary neoplasm or "transdifferentiation" in the setting of B-acute lymphoblastic leukemia. ( 27856472 )
2016
29
Disseminated histiocytic sarcoma in a child: a clinicopathological dichotomy with 8a88years survival. ( 27190112 )
2016
30
Circulating let-7g is down-regulated in Bernese Mountain dogs with disseminated histiocytic sarcoma and carcinomasA -A a prospective study. ( 26792388 )
2016
31
Microglioma in a child - a further case in support of the microglioma entity and distinction from histiocytic sarcoma. ( 27191913 )
2016
32
Cutaneous Histiocytic Sarcoma with Regional Lymph Node Metastasis in a Netherland Dwarf Rabbit (Oryctolagus cuniculus). ( 27890406 )
2016
33
NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-I_B signaling. ( 27105514 )
2016
34
Histological and immunohistochemical features of histiocytic sarcoma in four domestic ferrets (Mustela putorius furo). ( 26965237 )
2016
35
Diffuse Histiocytic Sarcoma Involving the Choroid. ( 27541306 )
2016
36
Long-term treatment with the oncolytic ECHO-7 virus Rigvir of a melanoma stage IV M1c patient, a small cell lung cancer stage IIIA patient, and a histiocytic sarcoma stage IV patient-three case reports. ( 27457663 )
2016
37
Primary Orbital Histiocytic Sarcoma in a Child Successfully Treated With Multiagent Chemotherapy. ( 27467374 )
2016
38
An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. ( 27325388 )
2016
39
Hepatic Involvement of Histiocytic Sarcoma: CT and MRI Findings. ( 27587965 )
2016
40
Clinical prognostic factors in canine histiocytic sarcoma. ( 27334037 )
2016
41
Primary histiocytic sarcoma of the uterine cervix: an extremely rare entity. ( 27828780 )
2016
42
Two cases of histiocytic sarcoma with BCL2 translocations and occult or subsequent follicular lymphoma. ( 27134111 )
2016
43
Evaluation of Costimulatory Molecules in Peripheral Blood Lymphocytes of Canine Patients with Histiocytic Sarcoma. ( 26901565 )
2016
44
Disseminated Histiocytic Sarcoma in an African Hedgehog (Atelerix albiventris). ( 27720131 )
2016
45
Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation. ( 27429816 )
2016
46
Persistent Morbillivirus Infection Leads to Altered Cortactin Distribution in Histiocytic Sarcoma Cells with Decreased Cellular Migration Capacity. ( 27911942 )
2016
47
Risk Factors Associated with Development of Histiocytic Sarcoma in Bernese Mountain Dogs. ( 27160025 )
2016
48
Histiocytic Sarcoma as a Secondary Malignancy: Pathobiology, Diagnosis, and Treatment. ( 26990812 )
2016
49
Comparison of conventional magnetic resonance imaging and nonenhanced three dimensional time-of-flight magnetic resonance angiography findings between dogs with meningioma and dogs with intracranial histiocytic sarcoma: 19 cases (2010-2014). ( 27135670 )
2016
50
Gastric histiocytic sarcoma in a dog. ( 27925661 )
2016

Variations for Histiocytic Sarcoma

Expression for Histiocytic Sarcoma

Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for Histiocytic Sarcoma

GO Terms for Histiocytic Sarcoma

Cellular components related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 BCL2 CSF1 CSF1R PTEN S100B
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 BRAF CSF1R HAVCR2 PTEN
3 cellular response to hypoxia GO:0071456 9.72 BCL2 PTEN S100B
4 hemopoiesis GO:0030097 9.69 BCL2 CSF1 CSF1R
5 regulation of protein stability GO:0031647 9.67 BCL2 CDKN2A PTEN
6 immune system process GO:0002376 9.63 CR1 CR2 CSF1 CSF1R HAVCR2 LGALS3
7 long-term synaptic potentiation GO:0060291 9.61 BRAF PTEN S100B
8 macrophage differentiation GO:0030225 9.56 CSF1 CSF1R
9 complement receptor mediated signaling pathway GO:0002430 9.52 CR1 CR2
10 B cell proliferation GO:0042100 9.5 BCL2 CR2 MS4A1
11 regulation of axon regeneration GO:0048679 9.48 BRAF PTEN
12 cell proliferation GO:0008283 9.43 BCL2 CSF1 CSF1R FSCN1 PTEN S100B
13 macrophage colony-stimulating factor signaling pathway GO:0038145 9.4 CSF1 CSF1R
14 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189 9.37 HAVCR2 LGALS3
15 negative regulation of immunological synapse formation GO:2000521 9.26 HAVCR2 LGALS3
16 innate immune response GO:0045087 9.17 CR1 CR2 CSF1 CSF1R HAVCR2 LGALS3

Sources for Histiocytic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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