MCID: HST016
MIFTS: 40

Histiocytic Sarcoma malady

Categories: Cancer diseases, Blood diseases, Rare diseases

Aliases & Classifications for Histiocytic Sarcoma

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Sources:
29ICD10, 30ICD10 via Orphanet, 39MESH via Orphanet, 53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Histiocytic Sarcoma:

Name: Histiocytic Sarcoma 53 67

Characteristics:

Orphanet epidemiological data:

53
histiocytic sarcoma:
Age of onset: Adult

Classifications:



External Ids:

Orphanet53 ORPHA86896
MESH via Orphanet39 D054747
UMLS via Orphanet68 C0334663
ICD10 via Orphanet30 C96.8
ICD1029 C96.8

Summaries for Histiocytic Sarcoma

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Wikipedia:70 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

MalaCards based summary: Histiocytic Sarcoma is related to autoimmune lymphoproliferative syndrome and malignant histiocytosis, and has symptoms including hepatomegaly An important gene associated with Histiocytic Sarcoma is CD163 (CD163 Molecule), and among its related pathways are Advanced glycosylation endproduct receptor signaling and LDL Oxidation in Atherogenesis. Affiliated tissues include brain, thyroid and bone, and related mouse phenotypes are integument and hematopoietic system.

Related Diseases for Histiocytic Sarcoma

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Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune lymphoproliferative syndrome29.4CD68, MUC1, PTEN, S100B
2malignant histiocytosis11.4
3reticulosarcoma10.9
4sarcoma10.8
5logopenic progressive aphasia10.7MUC1, S100B
6intermediate dend syndrome10.7MUC1, S100B
72q33.1 microdeletion syndrome10.7BRAF, MUC1
8lyme disease - neurological complications10.7MUC1, S100B
9anaplastic oligoastrocytoma10.7MUC1, S100B
10relapsing epidemic typhus10.7MUC1, S100B
11lymphangiosarcoma10.7MUC1, S100B
12pituitary deficiency due to rathke's pouch cysts10.6MUC1, S100B
13hypotonia10.6PTEN, S100B
14chondroblastoma10.6MUC1, S100B
15subacute leukemia10.6MUC1, S100B
16pseudoglandular variant testicular seminoma10.6MUC1, S100B
17pediculus humanus capitis infestation10.6MUC1, S100B
18lumbar plexus neoplasm10.6MUC1, S100B
19external ear disease10.6MUC1, S100B
20subependymal giant cell astrocytoma10.6MUC1, S100B
21pulmonary venoocclusive disease10.6BRAF, S100B
22bartholin's gland benign neoplasm10.6MUC1, S100B
23eccrine papillary adenoma10.5MUC1, S100B
24skin sarcoma10.5BRAF, MUC1
25pineoblastoma10.5BRAF, MUC1
26breast papillary carcinoma10.5MUC1, S100B
27polyomavirus allograft nephropathy10.5LGALS3, MUC1, S100B
28split hand split foot malformation autosomal recessive10.5BRAF, CDKN2A
29gallbladder adenoma10.5MUC1, S100B
30temporal lobe neoplasm10.5CD163, CD68
31epicardium cancer10.4BRAF, MUC1, S100B
32penile urethral cancer10.4CR1, CR2
33extracranial neuroblastoma10.4CDKN2A, MUC1
34skin glomangioma10.4MUC1, S100B
35luteoma10.4CD163, CD68
36intravascular fasciitis10.4CD68, MUC1
37microcystic meningioma10.4CD163, CD68
38diffuse pulmonary fibrosis10.4CD68, S100B
3910.4CD68, PTEN
40white platelet syndrome10.4CDKN2A, MS4A1, MUC1
41rhizomelic chondrodysplasia punctata10.4BRAF, CD163, CSF1
42ovarian surface papilloma10.4BRAF, MUC1
43frontotemporal dementia and/or amyotrophic lateral sclerosis 410.4BRAF, LGALS3, PTEN
44prostate stromal sarcoma10.4CR1, CR2
45penis verrucous carcinoma10.4CDKN2A, MUC1, S100B
46sclerosing liposarcoma10.4CDKN2A, MUC1, S100B
47central centrifugal cicatricial alopecia10.3CDKN2A, MUC1, S100B
48richter's syndrome10.3CDKN2A, LGALS3, MUC1
49angioma hereditary neurocutaneous10.3CR1, CR2
50mucinoses10.3CD163, CSF1, CSF1R

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to histiocytic sarcoma

Symptoms for Histiocytic Sarcoma

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UMLS symptoms related to Histiocytic Sarcoma:


hepatomegaly

Drugs & Therapeutics for Histiocytic Sarcoma

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Drugs for Histiocytic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LenalidomideapprovedPhase 2718191732-72-6216326
Synonyms:
1-oxo-2-(2,6-Dioxopiperidin-3-yl)-4-aminoisoindoline
191732-72-6
3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
346670-73-3
443912-14-9
AC-914
AC1L50II
AKOS005146276
ALBB-015321
Bio-0168
C467567
CC 5013
CC-5013
CC-5013, Revlimid, Lenalidomide
CC5013
CDC 501
CDC-501
CDC-5013
CHEMBL848
CID216326
Celgene brand of lenalidomide
D04687
 
DB00480
EC-000.2340
ENMD-0997
I06-0831
IMID-1
IMID-5013
IMiD3
IMiD3 cpd
IMid-1
LS-184040
Lenalidomide
Lenalidomide (USAN/INN)
Lenalidomide [USAN]
MolPort-003-848-370
NCGC00167491-01
NSC747972
Revamid
Revimid
Revlimid
Revlimid (Celgene)
Revlimid (TN)
S1029_Selleck
STK639603
Thalidomide analog CC-5013
UNII-F0P408N6V4
lenalidomide
2Anti-Infective AgentsPhase 221402
3Angiogenesis InhibitorsPhase 24143
4Immunosuppressive AgentsPhase 212770
5Anti-Bacterial AgentsPhase 210884
6Angiogenesis Modulating AgentsPhase 24072
7
Zidovudineapproved49430516-87-135370
Synonyms:
-Azido-3&prime
-deoxythymidine
1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine
3&prime
3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
3'-Azido-3'-deoxythymidine & Concanavalin A
3'-Azido-3'-deoxythymidine & Erythropoietin
3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19
3'-Azido-3'-deoxythymidine & Interleukin-1
3'-Azido-3'-deoxythymidine & Interleukin-2
3'-Azido-3'-deoxythymidine & Interleukin-6
3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6
3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon
3'-Azido-3'-deoxythymidine & Sho-Saiko-To
3'-Azido-3'-deoxythymidine (AIDS)
3'-Azido-3'deoxythymidine & Interferon .alpha.
3'-Azidothymidine
3'-Deoxy-3'-azidothymidine
3'-azido-3'-deoxythymidine, AZT
3-Azido-3-deoxythymidine
30516-87-1
399024-19-2
A2169_SIGMA
AC1L1TKL
AC1Q2OEK
AZT
AZT & CD4(178)-PE 40
AZT & Colony-stimulating factor 2
AZT & Concanavalin A (ConA)
AZT & EPO
AZT & GM-CSF
AZT & HPA
AZT & IFN.alpha.
AZT & IL-1
AZT & IL-2
AZT & IL-6
AZT & Interferon-.alpha.-2
AZT & Li & EPO
AZT & Li & GM-CSF
AZT & Li & IL-1
AZT & Li & IL-6
AZT & Lymphoblastoid Interferon
AZT & NP (from PHCA or HSA)
AZT & PM-19
AZT & SST
AZT & rIFN.alpha.2
AZT & rsCD4 & rIFN.alpha.A
AZT & rsT4
AZT & sCD4
AZT & srCD4
AZT (Antiviral)
AZT Antiviral
AZT TRANSPLACENTAL CARCINOGENESIS STUDY
AZT+PRO 140
AZT, Antiviral
Antiviral AZT
Apo-Zidovudine
Azidothymidine
Aztec
BB_NC-1012
BPBio1_000403
BRD-K72903603-001-04-6
BSPBio_000365
BSPBio_003153
BW A509U
BW-A 509U
BW-A-509U
BW-A509U
BWA 509U
BWA-509U
BWA509U
C07210
CCRIS 105
CHEBI:10110
CHEBI:127307
CHEMBL129
CID35370
 
CPD000058351
Compound S
Cpd S
D00413
D015215
DB00495
DRG-0004
DS-4152 & AZT
DivK1c_000524
HMS1921J20
HMS2090G11
HMS2092D06
HMS501K06
HSDB 6515
IDI1_000524
Interferon AD + 3'-azido-3'-deoxythymidine
Intron A & AZT
K7 [P Ti2 W10 O40]
KBio1_000524
KBio2_001828
KBio2_004396
KBio2_006964
KBio3_002653
KBioGR_000703
KBioSS_001828
LS-1159
Liposomal AZT-SN-1
Liposomal AZT-SN-3
MLS000028548
MLS001055351
MLS001076358
MLS002153202
MLS002222249
Met-SDF-1.beta. & AZT
Met-SDF-1.beta. & Zidovudine
MolPort-002-507-286
NCGC00023945-03
NCGC00023945-04
NCGC00023945-05
NCGC00023945-08
NCGC00178237-01
NCGC00178237-02
NINDS_000524
NSC 602670
Novo-Azt
PC-SOD+AZT
Prestwick3_000333
Propolis+AZT
Racemic Liposomal AZT
Retrovir
Retrovir (TN)
Retrovir(TM)
SAM002548971
SMR000058351
SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SPBio_000834
SPECTRUM1502109
STK801891
Spectrum2_000927
Spectrum3_001507
Spectrum4_000332
Spectrum5_001101
Spectrum_001348
UNII-4B9XT59T7S
ZDV
ZIDOVUDINE [AZT]
ZINC03779042
ZVD
Zidovudin
Zidovudina
Zidovudina [Spanish]
Zidovudine (JAN/USP/INN)
Zidovudine EP III
Zidovudine [USAN:INN:BAN:JAN]
Zidovudine+PRO 140
Zidovudinum
Zidovudinum [Latin]
antiviral
azidodeoxythymidine
rIFN-beta seron & AZT
racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
zidovudin
zidovudine
8Reverse Transcriptase Inhibitors1880
9Nucleic Acid Synthesis Inhibitors4855
10Anti-HIV Agents3100
11Antimetabolites11774
12Anti-Retroviral Agents3232
13Antiviral Agents9732

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Lenalidomide for Adult Histiocyte DisordersRecruitingNCT02523040Phase 2
2A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow TransplantCompletedNCT00002284

Search NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

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Anatomical Context for Histiocytic Sarcoma

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MalaCards organs/tissues related to Histiocytic Sarcoma:

35
Brain, Thyroid, Bone, Bone marrow, B cells, Spleen, Lymph node

Animal Models for Histiocytic Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Histiocytic Sarcoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3BRAF, CDKN2A, CSF1, CSF1R, LGALS3, PTEN
2MP:00053977.4BRAF, CD68, CDKN2A, CR2, CSF1, CSF1R
3MP:00053876.5BRAF, CD68, CDKN2A, CR2, CSF1, CSF1R

Publications for Histiocytic Sarcoma

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Articles related to Histiocytic Sarcoma:

(show top 50)    (show all 265)
idTitleAuthorsYear
1
Apoptosis inhibitor of macrophage (AIM) reduces cell number in canine histiocytic sarcoma cell lines. (27246397)
2016
2
Microglioma in a child - a further case in support of the microglioma entity and distinction from histiocytic sarcoma. (27191913)
2016
3
Two cases of histiocytic sarcoma with BCL2 translocations and occult or subsequent follicular lymphoma. (27134111)
2016
4
Cooperation of BRAF(F595L) and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling. (26582644)
2016
5
Hepatic Involvement of Histiocytic Sarcoma: CT and MRI Findings. (27587965)
2016
6
Diffuse Histiocytic Sarcoma Involving the Choroid. (27541306)
2016
7
An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. (27325388)
2016
8
Concomitant follicular lymphoma and histiocytic sarcoma: A rare progression, trans-differentiation or co-occurrence? (26549087)
2015
9
Histiocytic sarcoma with central nervous system involvement in dogs: 19 cases (2006-2012). (25711602)
2015
10
Survivin suppressor (YM155) enhances chemotherapeutic efficacy against canine histiocytic sarcoma in murine transplantation models. (25744435)
2015
11
Enhanced CT and FDG PET/CT in Histiocytic Sarcoma of the Pericardium. (26545021)
2015
12
A case of CD68 negative histiocytic sarcoma of axilla masquerading as metastatic breast cancer. (25031040)
2014
13
Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice. (24827933)
2014
14
Follicular lymphoma transformation into histiocytic sarcoma: indications for a common neoplastic progenitor. (24850291)
2014
15
Primary endobronchial histiocytic sarcoma in a case of papillary carcinoma thyroid: a complex clinical scenario. (25321458)
2014
16
Primary Histiocytic Sarcoma of the Central Nervous System. (25345462)
2014
17
Pulmonary histiocytic sarcoma in a rabbit. (23909927)
2013
18
Peri-articular histiocytic sarcoma and previous joint disease in Bernese Mountain Dogs. (23458888)
2013
19
Primary histiocytic sarcoma of the stomach: a case report with imaging findings. (23372369)
2013
20
Long-term remission after autologous stem-cell transplantation for relapsed histiocytic sarcoma. (22876158)
2012
21
Coexistence of Langerhans cell histiocytosis, Rosai-Dorfman disease and splenic lymphoma with fatal outcome after rapid development of histiocytic sarcoma of the liver. (23043641)
2012
22
Histiocytic sarcoma - targeted therapy: novel therapeutic options? A series of 4 cases. (22846978)
2012
23
Primary nasal histiocytic sarcoma of macrophage-myeloid cell type in a cat. (22520253)
2012
24
Amputation for histiocytic sarcoma in a cat. (22314091)
2012
25
Autologous hematopoietic stem-cell transplantation in combination with thalidomide as treatment for histiocytic sarcoma: a case report and review of the literature. (21220616)
2011
26
Histiocytic sarcoma involving lymph nodes: imaging appearance on gallium-67 and F-18 FDG PET/CT. (21552013)
2011
27
Synchronous histiocytic sarcoma and diffuse large B cell lymphoma involving the stomach: a case report and review of the literature. (21286876)
2011
28
Pediatric histiocytic sarcoma clonally related to precursor B-cell acute lymphoblastic leukemia with homozygous deletion of CDKN2A encoding p16INK4A. (20973102)
2011
29
Sequential development of histiocytic sarcoma and diffuse large b-cell lymphoma in a patient with a remote history of follicular lymphoma with genotypic evidence of a clonal relationship: a divergent (bilineal) neoplastic transformation of an indolent B-cell lymphoma in a single individual. (21317718)
2011
30
Hemophagocytic histiocytic sarcoma in a Japanese black cow. (20133954)
2010
31
Histiocytic sarcoma and underlying chronic myelomonocytic leukemia: a proposal for the developmental classification of histiocytic sarcoma. (20535595)
2010
32
Aggressive sporadic histiocytic sarcoma with immunoglobulin heavy chain gene rearrangement and t(14;18). (20976632)
2010
33
Histiocytic sarcoma arising in indolent small B-cell lymphoma: report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution. (20331331)
2010
34
Malignant histiocytoses/disseminated histiocytic sarcoma with hemophagocytic syndrome in a patient with mediastinal germ cell tumor. (18987551)
2009
35
MR imaging of histiocytic sarcoma of the canine brain. (19400464)
2009
36
Histiocytic sarcoma: identification of its histiocytic origin using immunohistochemistry. (18239326)
2008
37
Histiocytic sarcoma: PET-CT evaluation of a rare entity. (18982475)
2008
38
Canine ocular histiocytic sarcoma. (17445080)
2007
39
Histiocytic sarcoma of the spleen in flat-coated retrievers with regenerative anaemia and hypoproteinaemia. (16782856)
2006
40
Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin. (15050956)
2004
41
Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice. (15580705)
2004
42
Primary gastric histiocytic sarcoma in a dog--a case report. (15533119)
2004
43
Histiocytic sarcoma in C57BL/6J female mice is associated with liver hematopoiesis: review of 41 cases. (12746118)
2003
44
Histiocytic sarcoma involving the central nervous system: clinical, immunohistochemical, and molecular genetic studies of a case with review of the literature. (12548175)
2003
45
Macrophage-like cell line (HS-P) from a rat histiocytic sarcoma. (11222016)
2001
46
Morphological characteristics of a transplantable histiocytic sarcoma (HS-J) in F344 rats and appearance of renal tubular hyaline droplets in HS-J-bearing rats. (9076602)
1997
47
Diffuse pulmonary tumor microemboli from prostatic carcinoma with an associated fibrous histiocytic sarcoma. (2154098)
1990
48
Persistent Epstein-Barr virus infection and a histiocytic sarcoma in a renal transplant recipient. (2981149)
1985
49
Histiocytic sarcoma in Wistar rats. A light microscopic, immunohistochemical, and ultrastructural study. (6383258)
1984
50
Histiocytic sarcoma of the scrotum in a rat. (6281570)
1982

Variations for Histiocytic Sarcoma

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Expression for genes affiliated with Histiocytic Sarcoma

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Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for genes affiliated with Histiocytic Sarcoma

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GO Terms for genes affiliated with Histiocytic Sarcoma

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Cellular components related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CSF1-CSF1R complexGO:19906829.8CSF1, CSF1R

Biological processes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of immunological synapse formationGO:200052110.6HAVCR2, LGALS3
2negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:200118910.6HAVCR2, LGALS3
3regulation of axon regenerationGO:004867910.5BRAF, PTEN
4positive regulation of osteoclast differentiationGO:004567210.3CSF1, CSF1R
5macrophage colony-stimulating factor signaling pathwayGO:003814510.3CSF1, CSF1R
6macrophage differentiationGO:003022510.3CSF1, CSF1R
7complement receptor mediated signaling pathwayGO:000243010.2CR1, CR2
8long-term synaptic potentiationGO:00602919.5BRAF, PTEN, S100B
9positive regulation of ERK1 and ERK2 cascadeGO:00703749.3BRAF, CSF1R, HAVCR2, PTEN
10innate immune responseGO:00450878.3CR1, CR2, CSF1, CSF1R, HAVCR2, LGALS3
11cell proliferationGO:00082838.1CSF1, CSF1R, FSCN1, PTEN, S100B

Sources for Histiocytic Sarcoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet