MCID: HST016
MIFTS: 44

Histiocytic Sarcoma malady

Cancer diseases, Blood diseases, Rare diseases categories

Summaries for Histiocytic Sarcoma

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Wikipedia:63 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

MalaCards based summary: Histiocytic Sarcoma is related to sarcoma and histiocytosis. An important gene associated with Histiocytic Sarcoma is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Advanced glycosylation endproduct receptor signaling and LDL Oxidation in Atherogenesis. The compounds cr2+ and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid, spleen and brain, and related mouse phenotypes are skeleton and homeostasis/metabolism.

Aliases & Classifications for Histiocytic Sarcoma

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Sources:
47Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet, 25ICD10
See all sources

Histiocytic Sarcoma, Aliases & Descriptions:

Name: Histiocytic Sarcoma 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

47
histiocytic sarcoma:
Age of onset: Adult


External Ids:

Orphanet47 86896
ICD10 via Orphanet26 C96.8
UMLS via Orphanet61 C0334663
MESH via Orphanet34 D054747
ICD1025 C96.8

Related Diseases for Histiocytic Sarcoma

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Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.6PTPRC, S100B, CR2, CD163, SLPI, CSF1R
2histiocytosis31.3CD68, S100B, CD163
3malignant histiocytosis31.1CSF1R
4langerhans-cell histiocytosis30.9CD68, S100B
5rosai-dorfman disease30.9S100B, CD163
6chronic myelomonocytic leukemia30.8MPO, CSF1R
7precursor b-cell acute lymphoblastic leukemia29.9CDKN2A, PAX5, MPO, PTPRC, IGH
8reticulosarcoma29.8PTPRC, IGH, CD68, BCL6, LGALS3, PAX5
9follicular lymphoma29.7PTPRC, IGH, PAX5, MS4A1, CR2, CR1
10b-cell lymphomas29.6PAX5, CR2, CDKN2A, PTPRC, IGH, CR1
11glioblastoma29.5S100B, LGALS3, PTEN, CSF1R, CDKN2A
12leukemia29.4IGH, SLPI, MPO, PAX5, BCL6, CSF1R
13testicular lymphoma10.5BCL6
14central nervous system lymphoma10.5BCL6
15lymphoblastic leukemia10.5
16synovitis10.5CD163, CD68
17pigmented villonodular synovitis10.5CSF1R
18myeloid sarcoma10.5MPO
19gastric lymphoma10.4IGH, BCL6
20thyroiditis10.4
21lymphosarcoma10.4BCL6, IGH
22macroglobulinemia10.4PAX5
23thrombocytopenia10.4
24fibrous histiocytoma10.4S100B, CD163
25granular cell tumor10.4S100B, CD68
26acute myelomonocytic leukemia10.3CSF1R, MPO
27central nervous system lymphoma, primary10.3PAX5, BCL6
28encephalitis10.3CD68, PTPRC
29hematopoietic stem cell transplantation10.3
30squamous cell carcinoma, head and neck10.3MS4A1, IGH, PAX5
31bronchiectasis10.3SLPI, MPO
32burkitt lymphoma10.3BCL6, PAX5
33gliomatosis cerebri10.3PTEN
34cholangitis, primary sclerosing10.3MPO, SLPI
35chordoma10.3LGALS3, S100B
36cork-handlers' disease10.3SLPI, CD68, MPO
37malt lymphoma10.2BCL6, IGH
38giant cell glioblastoma10.2PTEN
39smooth muscle tumor10.2LGALS3, CR2, S100B
40diffuse large b-cell lymphoma10.2
41mediastinitis10.2
42bronchitis10.2MPO, SLPI
43transitional cell carcinoma10.2PAX5, BCL6, CSF1R
44malignant fibroxanthoma10.2PTPRC, S100B, CD68
45giant cell tumor10.2S100B, PTPRC
46anaplastic ependymoma10.1S100B, PTEN
47gemistocytic astrocytoma10.1PTEN, S100B
48peritonitis10.1MPO, SLPI, CR1
49hcl-v10.1PTPRC, BCL6
50leukemia, acute promyelocytic10.1CSF1R, MPO, PTPRC

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to histiocytic sarcoma

Symptoms for Histiocytic Sarcoma

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Drugs & Therapeutics for Histiocytic Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Histiocytic Sarcoma

Search NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

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Anatomical Context for Histiocytic Sarcoma

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MalaCards organs/tissues related to Histiocytic Sarcoma:

31
Thyroid, Spleen, Brain, B cells, Bone marrow, Bone, Lymph node, Spinal cord, Small intestine, Kidney, Liver, Monocytes, Skeletal muscle, Breast, Skin, Prostate, Testes, Myeloid, T cells

Animal Models for Histiocytic Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Histiocytic Sarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.1PTEN, PTPRC, PAX5, LGALS3, CSF1R, CDKN2A
2MP:00053767.3PTPRC, MPO, LGALS3, BCL6, CSF1R, CR2
3MP:00053846.8HAVCR2, PTEN, PTPRC, TIMD4, PAX5, LGALS3
4MP:00107686.5HAVCR2, PTEN, PTPRC, MPO, PAX5, LGALS3
5MP:00053975.4SLPI, HAVCR2, PTEN, PTPRC, MPO, TIMD4
6MP:00053875.3PAX5, TIMD4, MPO, PTPRC, PTEN, HAVCR2

Publications for Histiocytic Sarcoma

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Articles related to Histiocytic Sarcoma:

(show top 50)    (show all 208)
idTitleAuthorsYear
1
Histiocytic sarcoma with central nervous system involvement in dogs: 19 cases (2006-2012). (25711602)
2015
2
Survivin suppressor (YM155) enhances chemotherapeutic efficacy against canine histiocytic sarcoma in murine transplantation models. (25744435)
2015
3
Isolated cranial nerve palsies may point to primary histiocytic sarcoma. (25123571)
2014
4
A case of CD68 negative histiocytic sarcoma of axilla masquerading as metastatic breast cancer. (25031040)
2014
5
Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice. (24827933)
2014
6
Successful treatment of histiocytic sarcoma with induction chemotherapy consisting of dose-escalated CHOP plus etoposide and upfront consolidation auto-transplantation. (25062797)
2014
7
Follicular lymphoma transformation into histiocytic sarcoma: indications for a common neoplastic progenitor. (24850291)
2014
8
Primary gastric histiocytic sarcoma reminiscent of inflammatory pseudotumor: a case report with review of the literature. (25013428)
2014
9
Primary endobronchial histiocytic sarcoma in a case of papillary carcinoma thyroid: a complex clinical scenario. (25321458)
2014
10
Unusual presentation of a rare cancer: histiocytic sarcoma in the brain 16 years after treatment for acute lymphoblastic leukemia. (22997353)
2013
11
Pulmonary histiocytic sarcoma in a rabbit. (23909927)
2013
12
Identification of dasatinib as an in vitro potent growth inhibitor of canine histiocytic sarcoma cells. (23369384)
2013
13
Peri-articular histiocytic sarcoma and previous joint disease in Bernese Mountain Dogs. (23458888)
2013
14
What is your diagnosis? Disseminated histiocytic sarcoma. (24134574)
2013
15
Erythrophagocytosis Enhances Heme-Dependent Cytotoxicity of Antimalarial Drugs in Canine Histiocytic Sarcoma Cell Line DH82. (24065080)
2013
16
Primary leptomeningeal histiocytic sarcoma in a patient with a good outcome: a case report and review of the literature. (23668836)
2013
17
Primary histiocytic sarcoma of the stomach: a case report with imaging findings. (23372369)
2013
18
Long-term remission after autologous stem-cell transplantation for relapsed histiocytic sarcoma. (22876158)
2012
19
Histiocytic sarcoma of the central nervous system: a challenging diagnosis. (21186180)
2012
20
Coexistence of Langerhans cell histiocytosis, Rosai-Dorfman disease and splenic lymphoma with fatal outcome after rapid development of histiocytic sarcoma of the liver. (23043641)
2012
21
Histiocytic sarcoma - targeted therapy: novel therapeutic options? A series of 4 cases. (22846978)
2012
22
A rare case of primary extranodal, extradural histiocytic sarcoma of the thoracic spine and review of literature. (23061012)
2012
23
Histiocytic sarcoma transdifferentiated from follicular lymphoma presenting as a cutaneous tumor. (21883369)
2011
24
Autologous hematopoietic stem-cell transplantation in combination with thalidomide as treatment for histiocytic sarcoma: a case report and review of the literature. (21220616)
2011
25
Histiocytic sarcoma involving lymph nodes: imaging appearance on gallium-67 and F-18 FDG PET/CT. (21552013)
2011
26
Histiocytic sarcoma. (23284265)
2011
27
Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. (21615919)
2011
28
The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. (20656318)
2010
29
Histiocytic sarcoma with interdigitating dendritic cell differentiation: a case report with fine needle aspiration cytology and review of literature. (19845032)
2010
30
Hemophagocytic histiocytic sarcoma in a Japanese black cow. (20133954)
2010
31
Phase II, open-label trial of single-agent CCNU in dogs with previously untreated histiocytic sarcoma. (21155191)
2010
32
Malignant histiocytoses/disseminated histiocytic sarcoma with hemophagocytic syndrome in a patient with mediastinal germ cell tumor. (18987551)
2009
33
Brain tumours in two Bactrian camels: a histiocytic sarcoma and a meningioma. (19483210)
2009
34
MR imaging of histiocytic sarcoma of the canine brain. (19400464)
2009
35
Disseminated histiocytic sarcoma with peripheral blood involvement in a Bernese Mountain dog. (19171015)
2009
36
Histiocytic sarcoma: identification of its histiocytic origin using immunohistochemistry. (18239326)
2008
37
Histiocytic sarcoma localised in the thyroid: a case report. (18386009)
2008
38
Histiocytic sarcoma: PET-CT evaluation of a rare entity. (18982475)
2008
39
An atypical case of histiocytic sarcoma in a Wistar rat (Rattus norvegicus). (18222080)
2008
40
CCNU for the treatment of dogs with histiocytic sarcoma. (17338159)
2007
41
Canine ocular histiocytic sarcoma. (17445080)
2007
42
Histiocytic sarcoma of the spleen in flat-coated retrievers with regenerative anaemia and hypoproteinaemia. (16782856)
2006
43
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. (16697958)
2006
44
Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin. (15050956)
2004
45
Primary histiocytic sarcoma of the spleen associated with erythrophagocytic histiocytosis. (12747473)
2003
46
Histiocytic sarcoma of the spleen associated with hypoalbuminemia, hypo gamma-globulinemia and thrombocytopenia as a possibly unique clinical entity--report of three cases. (9720731)
1998
47
Morphological characteristics of a transplantable histiocytic sarcoma (HS-J) in F344 rats and appearance of renal tubular hyaline droplets in HS-J-bearing rats. (9076602)
1997
48
Histiocytic sarcoma. (8082925)
1994
49
Histiocytic sarcoma of the scrotum in a rat. (6281570)
1982
50
Malignant lymphoma of true histiocytic origin: histiocytic sarcoma. A morphological, ultrastructural, immunological, cytochemical and clinical study of 10 cases. (7281492)
1981

Variations for Histiocytic Sarcoma

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Expression for genes affiliated with Histiocytic Sarcoma

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Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for genes affiliated with Histiocytic Sarcoma

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Pathways related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0S100B, LGALS3
29.8CD68, MPO
39.7CSF1R, PAX5, MPO
4
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.7CR2, PTPRC, PTEN
5
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.5IGH, CR1, CR2
69.5MS4A1, CSF1R, CR1, CR2
79.2CR2, BCL6, PTPRC
8
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.0PTEN, BCL6, CDKN2A
98.9CSF1R, BCL6, PAX5, MPO
108.6BCL6, LGALS3, PAX5, MPO, PTPRC
11
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
8.5IGH, PTEN, PTPRC, BCL6, CR2

Compounds for genes affiliated with Histiocytic Sarcoma

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Compounds related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1cr2+4310.3CR2, CR1
2monochloroacetic acid4310.2PTPRC, MPO
3naphthol as-d chloroacetate4310.2PTPRC, MPO
4alpha-naphthyl acetate439.8MPO, CD68
5cytarabine43 49 1211.7MPO, CSF1R, CR1, CDKN2A
6dmso439.7PTPRC, MPO, CSF1R, CR1
7etoposide43 49 59 1212.7S100B, CSF1R, LGALS3, PTEN
8agar439.7CDKN2A, CSF1R, LGALS3, PTEN
9etidronate439.6PAX5, SLPI
10formaldehyde43 2410.5PTPRC, MPO, LGALS3, CR1, S100B
11wortmannin439.5S100B, CSF1R, LGALS3, PTEN
12fatty acid439.4CDKN2A, S100B, LGALS3, PTPRC, PTEN
13rituximab43 49 1211.3BCL6, MS4A1, PAX5
14butyrate439.3MPO, LGALS3, CDKN2A, SLPI
15progesterone43 28 59 24 1213.3PTEN, PTPRC, LGALS3, CSF1R, S100B, CDKN2A
16h2o2439.3PTEN, PTPRC, MPO, LGALS3, CDKN2A
17cyclosporin a43 28 5911.2PTPRC, CR1, CR2, S100B, SLPI
18phosphatidylinositol439.2PTEN, PTPRC, LGALS3, CSF1R, CR1, CR2
19imatinib43 49 1211.2PTEN, BCL6, CSF1R, S100B
20cyclophosphamide43 49 1211.2BCL6, MS4A1, MPO, PTEN
21agarose439.2IGH, PTPRC, S100B, CDKN2A, SLPI
22creatinine439.2MPO, PAX5, S100B, CDKN2A, SLPI
23superoxide43 2410.1SLPI, CR1, LGALS3, MPO, PTPRC
24cisplatin43 49 59 1212.1SLPI, CDKN2A, LGALS3, MPO, PTEN
25ethanol43 49 24 1212.1SLPI, S100B, CR1, PTEN
26iron43 2410.1MPO, S100B, CDKN2A, CD163, SLPI
27threonine439.1PTEN, PTPRC, LGALS3, CSF1R, CR2, S100B
28heparin43 28 24 1212.0PTPRC, MPO, LGALS3, CR1, S100B, SLPI
29vitamin d439.0PTEN, PAX5, LGALS3, CSF1R, CR1, SLPI
30steroid439.0PTEN, PAX5, CSF1R, S100B, CDKN2A, SLPI
31methionine439.0PTEN, PTPRC, CSF1R, CR1, S100B, SLPI
32testosterone43 59 24 1211.9PTEN, PTPRC, PAX5, S100B, CDKN2A, SLPI
33dexamethasone43 49 28 1211.9PTPRC, CSF1R, S100B, CDKN2A, CD163, SLPI
34vegf438.8PTEN, MPO, LGALS3, CSF1R, S100B, CDKN2A
35cysteine438.7PTEN, PTPRC, LGALS3, CSF1R, S100B, CDKN2A
36phospholipid438.7PTEN, CR1, S100B, SLPI
37lactate438.7MPO, LGALS3, BCL6, S100B, SLPI
38atp43 289.7PTEN, LGALS3, CSF1R, CR1, S100B, CDKN2A
39nitric oxide43 24 1210.7PTEN, MPO, LGALS3, CR1, S100B, CDKN2A
40oxygen43 249.7PTEN, MPO, LGALS3, CR1, S100B, CDKN2A
41oligonucleotide438.7IGH, PTEN, PAX5, LGALS3, CSF1R, CDKN2A
42hematoxylin438.6SLPI, CDKN2A, S100B, CR2, LGALS3, MS4A1
43lipid438.2PTEN, PTPRC, MS4A1, LGALS3, CSF1R, S100B
44cycloheximide437.9PTEN, PTPRC, BCL6, CSF1R, CR1, CR2
45estrogen437.8PTEN, PTPRC, LGALS3, BCL6, CSF1R, CR2
46retinoic acid43 248.7PTEN, MPO, LGALS3, BCL6, CSF1R, CR1
47tyrosine437.4PTEN, PTPRC, PAX5, LGALS3, BCL6, CSF1R
48calcium43 49 24 1210.3MS4A1, PAX5, MPO, PTPRC, PTEN, LGALS3
49serine437.2PTEN, PTPRC, MPO, PAX5, LGALS3, BCL6
50paraffin436.4CD163, PTEN, PTPRC, MPO, PAX5, CD68

GO Terms for genes affiliated with Histiocytic Sarcoma

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Cellular components related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.8CR2, MS4A1, PTPRC
2integral component of plasma membraneGO:00058878.7PTPRC, MS4A1, CSF1R, CR1, CD163
3extracellular vesicular exosomeGO:00700628.4SLPI, PTPRC, MPO, MS4A1, LGALS3, CR1
4plasma membraneGO:00058867.9PTEN, PTPRC, LGALS3, CSF1R, CR1, CR2

Biological processes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of protein stabilityGO:00316479.9CDKN2A, PTEN
2B cell proliferationGO:00421009.8PTPRC, MS4A1, CR2
3long-term synaptic potentiationGO:00602919.6S100B, PTEN
4negative regulation of cell-matrix adhesionGO:00019539.3CDKN2A, BCL6
5innate immune responseGO:00450879.0S100B, CR2, CR1, CSF1R, LGALS3, PTEN

Products for genes affiliated with Histiocytic Sarcoma

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Sources for Histiocytic Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet