MCID: HST016
MIFTS: 52

Histiocytic Sarcoma malady

Cancer diseases, Blood diseases, Rare diseases categories
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Summaries for Histiocytic Sarcoma

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Wikipedia:65 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

MalaCards based summary: Histiocytic Sarcoma is related to sarcoma and histiocytosis. An important gene associated with Histiocytic Sarcoma is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Advanced glycosylation endproduct receptor signaling and LDL Oxidation in Atherogenesis. The compounds cr2+ and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid, spleen and brain, and related mouse phenotypes are skeleton and homeostasis/metabolism.

Aliases & Classifications for Histiocytic Sarcoma

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Sources:
48Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
See all sources

Histiocytic Sarcoma, Aliases & Descriptions:

Name: Histiocytic Sarcoma 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
histiocytic sarcoma:
Age of onset: Adulthood


External Ids:

ICD10 via Orphanet26 C96.8
UMLS via Orphanet63 C0334663
MESH via Orphanet35 D054747
ICD1025 C96.8

Related Diseases for Histiocytic Sarcoma

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Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.6PTPRC, S100B, CR2, CD163, SLPI, CSF1R
2histiocytosis31.3CD68, S100B, CD163
3malignant histiocytosis31.1CSF1R
4langerhans-cell histiocytosis30.9CD68, S100B
5rosai-dorfman disease30.9S100B, CD163
6hairy cell leukemia30.3PTPRC, BCL6
7meningioma30.1CD68, PTEN, S100B
8follicular lymphoma29.7PTPRC, IGH, PAX5, MS4A1, CR2, CR1
9b-cell lymphomas29.6PAX5, CR2, CDKN2A, PTPRC, IGH, CR1
10glioblastoma29.5S100B, LGALS3, PTEN, CSF1R, CDKN2A
11acute lymphoblastic leukemia29.5IGH, PTPRC, MPO, PAX5, BCL6, CDKN2A
12leukemia29.4IGH, SLPI, MPO, PAX5, BCL6, CSF1R
13testicular lymphoma10.6BCL6
14central nervous system lymphoma10.5BCL6
15synovitis10.5CD163, CD68
16pigmented villonodular synovitis10.5CSF1R
17myeloid sarcoma10.5MPO
18gastric lymphoma10.4IGH, BCL6
19lymphoblastic leukemia10.4
20lymphosarcoma10.4BCL6, IGH
21macroglobulinemia10.4PAX5
22fibrous histiocytoma10.4S100B, CD163
23thrombocytopenia10.4
24thyroiditis10.4
25granular cell tumor10.4S100B, CD68
26acute myelomonocytic leukemia10.3CSF1R, MPO
27central nervous system lymphoma, primary10.3PAX5, BCL6
28encephalitis10.3CD68, PTPRC
29hematopoietic stem cell transplantation10.3
30chronic lymphocytic leukemia10.3MS4A1, IGH, PAX5
31bronchiectasis10.3SLPI, MPO
32pdgfrb-associated chronic eosinophilic leukemia10.3MPO, CSF1R
33burkitt's lymphoma10.3BCL6, PAX5
34gliomatosis cerebri10.3PTEN
35primary sclerosing cholangitis10.3MPO, SLPI
36chordoma10.3LGALS3, S100B
37cork-handlers' disease10.3SLPI, CD68, MPO
38malt lymphoma10.3BCL6, IGH
39giant cell glioblastoma10.3PTEN
40smooth muscle tumor10.2LGALS3, CR2, S100B
41chronic myelomonocytic leukemia10.2
42diffuse large b-cell lymphoma10.2
43mediastinitis10.2
44germ cell tumors10.2
45bronchitis10.2MPO, SLPI
46transitional cell carcinoma10.2PAX5, BCL6, CSF1R
47malignant fibroxanthoma10.2PTPRC, S100B, CD68
48giant cell tumor10.2S100B, PTPRC
49anaplastic ependymoma10.1S100B, PTEN
50gemistocytic astrocytoma10.1PTEN, S100B

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to histiocytic sarcoma

Symptoms for Histiocytic Sarcoma

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Drugs & Therapeutics for Histiocytic Sarcoma

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Drug clinical trials:

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Search NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

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Anatomical Context for Histiocytic Sarcoma

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MalaCards organs/tissues related to Histiocytic Sarcoma:

32
Thyroid, Spleen, Brain, B cells, Bone marrow, Bone, Lymph node, Spinal cord, Small intestine, Kidney, Liver, Monocytes, Skeletal muscle, Breast, Skin, Prostate, Testes, Myeloid, T cells

Animal Models for Histiocytic Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Histiocytic Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.1PTEN, PTPRC, PAX5, LGALS3, CSF1R, CDKN2A
2MP:00053767.3PTPRC, MPO, LGALS3, BCL6, CSF1R, CR2
3MP:00053846.8HAVCR2, PTEN, PTPRC, TIMD4, PAX5, LGALS3
4MP:00107686.5HAVCR2, PTEN, PTPRC, MPO, PAX5, LGALS3
5MP:00053975.4SLPI, HAVCR2, PTEN, PTPRC, MPO, TIMD4
6MP:00053875.3PAX5, TIMD4, MPO, PTPRC, PTEN, HAVCR2

Publications for Histiocytic Sarcoma

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Articles related to Histiocytic Sarcoma:

(show top 50)    (show all 196)
idTitleAuthorsYear
1
Isolated cranial nerve palsies may point to primary histiocytic sarcoma. (25123571)
2014
2
A case of CD68 negative histiocytic sarcoma of axilla masquerading as metastatic breast cancer. (25031040)
2014
3
Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice. (24827933)
2014
4
Successful treatment of histiocytic sarcoma with induction chemotherapy consisting of dose-escalated CHOP plus etoposide and upfront consolidation auto-transplantation. (25062797)
2014
5
Follicular lymphoma transformation into histiocytic sarcoma: indications for a common neoplastic progenitor. (24850291)
2014
6
Primary gastric histiocytic sarcoma reminiscent of inflammatory pseudotumor: a case report with review of the literature. (25013428)
2014
7
Primary endobronchial histiocytic sarcoma in a case of papillary carcinoma thyroid: a complex clinical scenario. (25321458)
2014
8
Unusual presentation of a rare cancer: histiocytic sarcoma in the brain 16 years after treatment for acute lymphoblastic leukemia. (22997353)
2013
9
Pulmonary histiocytic sarcoma in a rabbit. (23909927)
2013
10
Identification of dasatinib as an in vitro potent growth inhibitor of canine histiocytic sarcoma cells. (23369384)
2013
11
Peri-articular histiocytic sarcoma and previous joint disease in Bernese Mountain Dogs. (23458888)
2013
12
What is your diagnosis? Disseminated histiocytic sarcoma. (24134574)
2013
13
Erythrophagocytosis Enhances Heme-Dependent Cytotoxicity of Antimalarial Drugs in Canine Histiocytic Sarcoma Cell Line DH82. (24065080)
2013
14
Primary leptomeningeal histiocytic sarcoma in a patient with a good outcome: a case report and review of the literature. (23668836)
2013
15
Primary histiocytic sarcoma of the stomach: a case report with imaging findings. (23372369)
2013
16
Long-term remission after autologous stem-cell transplantation for relapsed histiocytic sarcoma. (22876158)
2012
17
Histiocytic sarcoma of the central nervous system: a challenging diagnosis. (21186180)
2012
18
Coexistence of Langerhans cell histiocytosis, Rosai-Dorfman disease and splenic lymphoma with fatal outcome after rapid development of histiocytic sarcoma of the liver. (23043641)
2012
19
Histiocytic sarcoma - targeted therapy: novel therapeutic options? A series of 4 cases. (22846978)
2012
20
A rare case of primary extranodal, extradural histiocytic sarcoma of the thoracic spine and review of literature. (23061012)
2012
21
Histiocytic sarcoma transdifferentiated from follicular lymphoma presenting as a cutaneous tumor. (21883369)
2011
22
Autologous hematopoietic stem-cell transplantation in combination with thalidomide as treatment for histiocytic sarcoma: a case report and review of the literature. (21220616)
2011
23
Histiocytic sarcoma involving lymph nodes: imaging appearance on gallium-67 and F-18 FDG PET/CT. (21552013)
2011
24
Histiocytic sarcoma. (23284265)
2011
25
Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. (21615919)
2011
26
The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. (20656318)
2010
27
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. (20548287)
2010
28
Histiocytic sarcoma with interdigitating dendritic cell differentiation: a case report with fine needle aspiration cytology and review of literature. (19845032)
2010
29
Hemophagocytic histiocytic sarcoma in a Japanese black cow. (20133954)
2010
30
Phase II, open-label trial of single-agent CCNU in dogs with previously untreated histiocytic sarcoma. (21155191)
2010
31
Histiocytic sarcoma arising from lymphomas via transdifferentiation pathway during clonal evolution. (20388055)
2010
32
Malignant histiocytoses/disseminated histiocytic sarcoma with hemophagocytic syndrome in a patient with mediastinal germ cell tumor. (18987551)
2009
33
Brain tumours in two Bactrian camels: a histiocytic sarcoma and a meningioma. (19483210)
2009
34
MR imaging of histiocytic sarcoma of the canine brain. (19400464)
2009
35
Disseminated histiocytic sarcoma with peripheral blood involvement in a Bernese Mountain dog. (19171015)
2009
36
Histiocytic sarcoma: identification of its histiocytic origin using immunohistochemistry. (18239326)
2008
37
Histiocytic sarcoma localised in the thyroid: a case report. (18386009)
2008
38
Histiocytic sarcoma: PET-CT evaluation of a rare entity. (18982475)
2008
39
An atypical case of histiocytic sarcoma in a Wistar rat (Rattus norvegicus). (18222080)
2008
40
CCNU for the treatment of dogs with histiocytic sarcoma. (17338159)
2007
41
Canine ocular histiocytic sarcoma. (17445080)
2007
42
Histiocytic sarcoma of the spleen in flat-coated retrievers with regenerative anaemia and hypoproteinaemia. (16782856)
2006
43
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. (16697958)
2006
44
Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin. (15050956)
2004
45
Primary histiocytic sarcoma of the spleen associated with erythrophagocytic histiocytosis. (12747473)
2003
46
Histiocytic sarcoma of the spleen associated with hypoalbuminemia, hypo gamma-globulinemia and thrombocytopenia as a possibly unique clinical entity--report of three cases. (9720731)
1998
47
Morphological characteristics of a transplantable histiocytic sarcoma (HS-J) in F344 rats and appearance of renal tubular hyaline droplets in HS-J-bearing rats. (9076602)
1997
48
Histiocytic sarcoma. (8082925)
1994
49
Histiocytic sarcoma of the scrotum in a rat. (6281570)
1982
50
Malignant lymphoma of true histiocytic origin: histiocytic sarcoma. A morphological, ultrastructural, immunological, cytochemical and clinical study of 10 cases. (7281492)
1981

Variations for Histiocytic Sarcoma

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Expression for genes affiliated with Histiocytic Sarcoma

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Expression patterns in normal tissues for genes affiliated with Histiocytic Sarcoma

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Pathways for genes affiliated with Histiocytic Sarcoma

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Pathways related to Histiocytic Sarcoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0S100B, LGALS3
29.8CD68, MPO
39.7CSF1R, PAX5, MPO
4
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.7CR2, PTPRC, PTEN
5
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.5IGH, CR1, CR2
69.5MS4A1, CSF1R, CR1, CR2
79.2CR2, BCL6, PTPRC
8
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.0PTEN, BCL6, CDKN2A
98.9CSF1R, BCL6, PAX5, MPO
108.6BCL6, LGALS3, PAX5, MPO, PTPRC
11
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
8.5IGH, PTEN, PTPRC, BCL6, CR2

Compounds for genes affiliated with Histiocytic Sarcoma

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Compounds related to Histiocytic Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1cr2+4410.3CR2, CR1
2monochloroacetic acid4410.2PTPRC, MPO
3naphthol as-d chloroacetate4410.2PTPRC, MPO
4cytarabine44 50 1111.7CSF1R, CDKN2A, MPO, CR1
5etidronate449.7SLPI, PAX5
6alpha-naphthyl acetate449.7CD68, MPO
7dmso449.7CR1, PTPRC, MPO, CSF1R
8etoposide44 50 61 1112.7LGALS3, PTEN, S100B, CSF1R
9agar449.7CDKN2A, CSF1R, PTEN, LGALS3
10formaldehyde44 2410.5S100B, LGALS3, CR1, PTPRC, MPO
11wortmannin449.5S100B, CSF1R, LGALS3, PTEN
12fatty acid449.4CDKN2A, PTEN, S100B, LGALS3, PTPRC
13rituximab44 50 1111.3BCL6, MS4A1, PAX5
14butyrate449.3LGALS3, SLPI, MPO, CDKN2A
15progesterone44 28 61 24 1113.3CDKN2A, S100B, CSF1R, PTPRC, PTEN, LGALS3
16h2o2449.3PTEN, CDKN2A, LGALS3, MPO, PTPRC
17cyclosporin a44 28 6111.2SLPI, S100B, PTPRC, CR1, CR2
18phosphatidylinositol449.2PTPRC, LGALS3, CSF1R, CR1, CR2, PTEN
19imatinib44 50 1111.2CSF1R, PTEN, BCL6, S100B
20cyclophosphamide44 50 1111.2MS4A1, MPO, PTEN, BCL6
21agarose449.2CDKN2A, IGH, S100B, SLPI, PTPRC
22creatinine449.2S100B, CDKN2A, SLPI, MPO, PAX5
23superoxide44 2410.1CR1, SLPI, MPO, LGALS3, PTPRC
24cisplatin44 50 61 1112.1PTEN, MPO, SLPI, CDKN2A, LGALS3
25ethanol44 50 24 1112.1S100B, PTEN, CR1, SLPI
26iron44 2410.1SLPI, CD163, CDKN2A, S100B, MPO
27threonine449.1LGALS3, PTPRC, PTEN, CDKN2A, CSF1R, CR2
28heparin44 28 24 1112.0SLPI, LGALS3, PTPRC, MPO, S100B, CR1
29vitamin d449.0CR1, LGALS3, CSF1R, PTEN, PAX5, SLPI
30steroid449.0PTEN, PAX5, SLPI, CSF1R, S100B, CDKN2A
31methionine449.0PTPRC, PTEN, CSF1R, CR1, S100B, SLPI
32testosterone44 61 24 1111.9SLPI, CDKN2A, S100B, PAX5, PTPRC, PTEN
33dexamethasone44 50 28 1111.9SLPI, CDKN2A, S100B, CD163, CSF1R, PTPRC
34vegf448.8CDKN2A, CSF1R, LGALS3, S100B, MPO, PTEN
35cysteine448.7LGALS3, PTPRC, CDKN2A, S100B, SLPI, CSF1R
36phospholipid448.7SLPI, PTEN, CR1, S100B
37lactate448.7MPO, SLPI, S100B, BCL6, LGALS3
38atp44 289.7SLPI, CSF1R, LGALS3, S100B, PTEN, CR1
39nitric oxide44 24 1110.7LGALS3, S100B, CDKN2A, CR1, PTEN, SLPI
40oxygen44 249.7S100B, CR1, LGALS3, CDKN2A, PTEN, SLPI
41oligonucleotide448.7IGH, SLPI, CDKN2A, CSF1R, LGALS3, PAX5
42hematoxylin448.6CDKN2A, PTEN, CR2, S100B, LGALS3, PTPRC
43lipid448.2CDKN2A, CSF1R, MS4A1, LGALS3, S100B, CD68
44cycloheximide447.9PTEN, PTPRC, BCL6, SLPI, CSF1R, CDKN2A
45estrogen447.8PTPRC, BCL6, PTEN, LGALS3, CSF1R, CR2
46retinoic acid44 248.7S100B, CDKN2A, CR1, PTEN, MPO, LGALS3
47tyrosine447.4CSF1R, BCL6, PAX5, SLPI, CR2, CR1
48calcium44 50 24 1110.3PTEN, PAX5, MS4A1, CDKN2A, SLPI, S100B
49serine447.2PTEN, MPO, PAX5, LGALS3, BCL6, CSF1R
50paraffin446.4CR2, CSF1R, BCL6, LGALS3, MS4A1, PAX5

GO Terms for genes affiliated with Histiocytic Sarcoma

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Cellular components related to Histiocytic Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.8MS4A1, CR2, PTPRC
2integral component of plasma membraneGO:0058878.7CD163, MS4A1, PTPRC, CSF1R, CR1
3extracellular vesicular exosomeGO:0700628.4PTPRC, MPO, MS4A1, LGALS3, CR1, CR2
4plasma membraneGO:0058867.9CD163, CD68, CR2, PTEN, CR1, CSF1R

Biological processes related to Histiocytic Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of protein stabilityGO:0316479.9CDKN2A, PTEN
2B cell proliferationGO:0421009.8PTPRC, MS4A1, CR2
3long-term synaptic potentiationGO:0602919.6S100B, PTEN
4negative regulation of cell-matrix adhesionGO:0019539.3CDKN2A, BCL6
5innate immune responseGO:0450879.0S100B, CR2, CR1, CSF1R, LGALS3, PTEN

Products for genes affiliated with Histiocytic Sarcoma

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Sources for Histiocytic Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet