MCID: HST016
MIFTS: 52

Histiocytic Sarcoma malady

Cancer diseases, Blood diseases, Rare diseases categories
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Summaries for Histiocytic Sarcoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

MalaCards: Histiocytic Sarcoma is related to sarcoma and histiocytosis. An important gene associated with Histiocytic Sarcoma is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Advanced glycosylation endproduct receptor signaling and LDL Oxidation in Atherogenesis. The compounds cr2+ and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid, spleen and brain, and related mouse phenotypes are skeleton and homeostasis/metabolism.

Aliases & Classifications for Histiocytic Sarcoma

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49Orphanet, 62UMLS, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

49
histiocytic sarcoma:
Age of onset: Adulthood


Aliases & Descriptions:

histiocytic sarcoma 49 62


External Ids:

MESH via Orphanet36 D054747
SNOMED-CT via Orphanet59 109988003, 128813000
ICD10 via Orphanet26 C96.8
UMLS via Orphanet63 C0334663
ICD1025 C96.8

Related Diseases for Histiocytic Sarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.7PTPRC, CSF1R, CR2, S100B, CD163, SLPI
2histiocytosis30.9S100B, CD68
3malignant histiocytosis30.5CSF1R
4rosai-dorfman disease30.5S100B, CD163
5chronic myelomonocytic leukemia30.4CSF1R, MPO
6leukemia30.3IGH, PTPRC, MPO, PAX5, BCL6, CSF1R
7b-cell lymphomas30.3IGH, PTPRC, PAX5, MS4A1, BCL6, CR1
8follicular lymphoma30.1IGH, CR2, CR1, BCL6, LGALS3, MS4A1
9meningioma30.1PTEN, S100B, CD68
10thrombocytopenia10.4
11lymphoblastic leukemia10.3
12thyroiditis10.3
13hematopoietic stem cell transplantation10.3
14langerhans-cell histiocytosis10.2
15diffuse large b-cell lymphoma10.2
16mediastinitis10.2
17germ cell tumors10.2
18testicular lymphoma10.1BCL6
19central nervous system lymphoma10.1BCL6
20synovitis10.1CD163, CD68
21pigmented villonodular synovitis10.1CSF1R
22myeloid sarcoma10.1MPO
23gastric lymphoma10.1IGH, BCL6
24lymphosarcoma10.1IGH, BCL6
25macroglobulinemia10.1PAX5
26fibrous histiocytoma10.1S100B, CD163
27granular cell tumor10.1S100B, CD68
28acute myelomonocytic leukemia10.1MPO, CSF1R
29central nervous system lymphoma, primary10.1PAX5, BCL6
30encephalitis10.1CD68, PTPRC
31tropical spastic paraparesis10.1
32duodenal ulcer10.1
33autoimmune lymphoproliferative syndrome10.1
34interdigitating dendritic cell sarcoma10.1
35duodenitis10.1
36cerebritis10.1
37mantle cell lymphoma10.1
38dendritic cell sarcoma10.1
39glomerulonephritis10.1
40hemolytic anemia10.1
41hepatitis10.1
42meningitis10.1
43myelofibrosis10.1
44pneumothorax10.1
45prostatitis10.1
46purpura10.1
47chylous ascites10.1
48indolent b cell lymphoma10.1
49spastic paraparesis10.1
50splenomegaly10.1

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to histiocytic sarcoma

Symptoms for Histiocytic Sarcoma

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Drugs & Therapeutics for Histiocytic Sarcoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Histiocytic Sarcoma

Search NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

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Anatomical Context for Histiocytic Sarcoma

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33MalaCards
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MalaCards organs/tissues related to Histiocytic Sarcoma:

33
Thyroid, Spleen, Brain, Bone marrow, B cells, Bone, Lymph node, Spinal cord, Monocytes, Liver, Kidney, Small intestine, Prostate, Testes, Myeloid, Skeletal muscle, T cells, Skin

Animal Models for Histiocytic Sarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Histiocytic Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.1PTEN, PTPRC, PAX5, LGALS3, CSF1R, CDKN2A
2MP:00053767.3PTPRC, MPO, LGALS3, BCL6, CSF1R, CR2
3MP:00053846.8HAVCR2, PTEN, PTPRC, TIMD4, PAX5, LGALS3
4MP:00107686.5HAVCR2, PTEN, PTPRC, MPO, PAX5, LGALS3
5MP:00053975.4SLPI, HAVCR2, PTEN, PTPRC, MPO, TIMD4
6MP:00053875.3PAX5, TIMD4, MPO, PTPRC, PTEN, HAVCR2

Publications for Histiocytic Sarcoma

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52PubMed
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Articles related to Histiocytic Sarcoma:

(show top 50)    (show all 177)
idTitleAuthorsYear
1
Unusual presentation of a rare cancer: histiocytic sarcoma in the brain 16 years after treatment for acute lymphoblastic leukemia. (22997353)
2013
2
Pulmonary histiocytic sarcoma in a rabbit. (23909927)
2013
3
Identification of dasatinib as an in vitro potent growth inhibitor of canine histiocytic sarcoma cells. (23369384)
2013
4
Peri-articular histiocytic sarcoma and previous joint disease in Bernese Mountain Dogs. (23458888)
2013
5
What is your diagnosis? Disseminated histiocytic sarcoma. (24134574)
2013
6
Erythrophagocytosis Enhances Heme-Dependent Cytotoxicity of Antimalarial Drugs in Canine Histiocytic Sarcoma Cell Line DH82. (24065080)
2013
7
Primary leptomeningeal histiocytic sarcoma in a patient with a good outcome: a case report and review of the literature. (23668836)
2013
8
Primary histiocytic sarcoma of the stomach: a case report with imaging findings. (23372369)
2013
9
Long-term remission after autologous stem-cell transplantation for relapsed histiocytic sarcoma. (22876158)
2012
10
Histiocytic sarcoma of the central nervous system: a challenging diagnosis. (21186180)
2012
11
Coexistence of Langerhans cell histiocytosis, Rosai-Dorfman disease and splenic lymphoma with fatal outcome after rapid development of histiocytic sarcoma of the liver. (23043641)
2012
12
Histiocytic sarcoma - targeted therapy: novel therapeutic options? A series of 4 cases. (22846978)
2012
13
A rare case of primary extranodal, extradural histiocytic sarcoma of the thoracic spine and review of literature. (23061012)
2012
14
Primary nasal histiocytic sarcoma of macrophage-myeloid cell type in a cat. (22520253)
2012
15
Histiocytic sarcoma transdifferentiated from follicular lymphoma presenting as a cutaneous tumor. (21883369)
2011
16
Autologous hematopoietic stem-cell transplantation in combination with thalidomide as treatment for histiocytic sarcoma: a case report and review of the literature. (21220616)
2011
17
Histiocytic sarcoma involving lymph nodes: imaging appearance on gallium-67 and F-18 FDG PET/CT. (21552013)
2011
18
Histiocytic sarcoma. (23284265)
2011
19
Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. (21615919)
2011
20
Synchronous histiocytic sarcoma and diffuse large B cell lymphoma involving the stomach: a case report and review of the literature. (21286876)
2011
21
The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. (20656318)
2010
22
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. (20548287)
2010
23
Histiocytic sarcoma with interdigitating dendritic cell differentiation: a case report with fine needle aspiration cytology and review of literature. (19845032)
2010
24
Hemophagocytic histiocytic sarcoma in a Japanese black cow. (20133954)
2010
25
Phase II, open-label trial of single-agent CCNU in dogs with previously untreated histiocytic sarcoma. (21155191)
2010
26
Histiocytic sarcoma arising from lymphomas via transdifferentiation pathway during clonal evolution. (20388055)
2010
27
Malignant histiocytoses/disseminated histiocytic sarcoma with hemophagocytic syndrome in a patient with mediastinal germ cell tumor. (18987551)
2009
28
Brain tumours in two Bactrian camels: a histiocytic sarcoma and a meningioma. (19483210)
2009
29
MR imaging of histiocytic sarcoma of the canine brain. (19400464)
2009
30
Disseminated histiocytic sarcoma with peripheral blood involvement in a Bernese Mountain dog. (19171015)
2009
31
Histiocytic sarcoma: identification of its histiocytic origin using immunohistochemistry. (18239326)
2008
32
Histiocytic sarcoma localised in the thyroid: a case report. (18386009)
2008
33
Histiocytic sarcoma: PET-CT evaluation of a rare entity. (18982475)
2008
34
An atypical case of histiocytic sarcoma in a Wistar rat (Rattus norvegicus). (18222080)
2008
35
CCNU for the treatment of dogs with histiocytic sarcoma. (17338159)
2007
36
Canine ocular histiocytic sarcoma. (17445080)
2007
37
Histiocytic sarcoma of the spleen in flat-coated retrievers with regenerative anaemia and hypoproteinaemia. (16782856)
2006
38
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. (16697958)
2006
39
Histiocytic sarcoma associated with Hodgkin's disease. (16444303)
2005
40
Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin. (15050956)
2004
41
Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice. (15580705)
2004
42
Primary histiocytic sarcoma of the spleen associated with erythrophagocytic histiocytosis. (12747473)
2003
43
Histiocytic sarcoma in C57BL/6J female mice is associated with liver hematopoiesis: review of 41 cases. (12746118)
2003
44
Histiocytic sarcoma of the spleen associated with hypoalbuminemia, hypo gamma-globulinemia and thrombocytopenia as a possibly unique clinical entity--report of three cases. (9720731)
1998
45
Morphological characteristics of a transplantable histiocytic sarcoma (HS-J) in F344 rats and appearance of renal tubular hyaline droplets in HS-J-bearing rats. (9076602)
1997
46
Histiocytic sarcoma. (8082925)
1994
47
Diffuse pulmonary tumor microemboli from prostatic carcinoma with an associated fibrous histiocytic sarcoma. (2154098)
1990
48
Morphologic studies on a murine reticulum cell sarcoma (histiocytic sarcoma) of histiocytic origin and its metastases. (6349101)
1983
49
Histiocytic sarcoma of the scrotum in a rat. (6281570)
1982
50
Malignant lymphoma of true histiocytic origin: histiocytic sarcoma. A morphological, ultrastructural, immunological, cytochemical and clinical study of 10 cases. (7281492)
1981

Variations for Histiocytic Sarcoma

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Expression for genes affiliated with Histiocytic Sarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Histiocytic Sarcoma

Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for genes affiliated with Histiocytic Sarcoma

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Sources:
50PathCards, 55Reactome, 53QIAGEN, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 57SinoBiological, 5Cell Signaling Technology, 54R&D Systems
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Pathways related to Histiocytic Sarcoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0S100B, LGALS3
29.8CD68, MPO
39.7CSF1R, PAX5, MPO
4
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.7CR2, PTPRC, PTEN
5
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.5IGH, CR1, CR2
69.5MS4A1, CSF1R, CR1, CR2
79.2CR2, BCL6, PTPRC
8
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.0PTEN, BCL6, CDKN2A
98.9CSF1R, BCL6, PAX5, MPO
108.6BCL6, LGALS3, PAX5, MPO, PTPRC
11
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
8.5IGH, PTEN, PTPRC, BCL6, CR2

Compounds for genes affiliated with Histiocytic Sarcoma

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 29IUPHAR
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Compounds related to Histiocytic Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1cr2+4510.3CR2, CR1
2monochloroacetic acid4510.2PTPRC, MPO
3naphthol as-d chloroacetate4510.2PTPRC, MPO
4cytarabine45 51 1111.7CSF1R, CDKN2A, MPO, CR1
5etidronate459.7SLPI, PAX5
6alpha-naphthyl acetate459.7CD68, MPO
7dmso459.7CR1, PTPRC, MPO, CSF1R
8etoposide45 51 61 1112.7LGALS3, PTEN, S100B, CSF1R
9agar459.7CDKN2A, CSF1R, PTEN, LGALS3
10formaldehyde45 2410.5S100B, LGALS3, CR1, PTPRC, MPO
11wortmannin459.5S100B, CSF1R, LGALS3, PTEN
12fatty acid459.4CDKN2A, PTEN, S100B, LGALS3, PTPRC
13rituximab45 51 1111.3BCL6, MS4A1, PAX5
14butyrate459.3LGALS3, SLPI, MPO, CDKN2A
15progesterone45 29 61 24 1113.3CDKN2A, S100B, CSF1R, PTPRC, PTEN, LGALS3
16h2o2459.3PTEN, CDKN2A, LGALS3, MPO, PTPRC
17cyclosporin a45 29 6111.2SLPI, S100B, PTPRC, CR1, CR2
18phosphatidylinositol459.2PTPRC, LGALS3, CSF1R, CR1, CR2, PTEN
19imatinib45 51 1111.2CSF1R, PTEN, BCL6, S100B
20cyclophosphamide45 51 1111.2MS4A1, MPO, PTEN, BCL6
21agarose459.2CDKN2A, IGH, S100B, SLPI, PTPRC
22creatinine459.2S100B, CDKN2A, SLPI, MPO, PAX5
23superoxide45 2410.1CR1, SLPI, MPO, LGALS3, PTPRC
24cisplatin45 51 61 1112.1PTEN, MPO, SLPI, CDKN2A, LGALS3
25ethanol45 51 24 1112.1S100B, PTEN, CR1, SLPI
26iron45 2410.1SLPI, CD163, CDKN2A, S100B, MPO
27threonine459.1LGALS3, PTPRC, PTEN, CDKN2A, CSF1R, CR2
28heparin45 29 24 1112.0SLPI, LGALS3, PTPRC, MPO, S100B, CR1
29vitamin d459.0CR1, LGALS3, CSF1R, PTEN, PAX5, SLPI
30steroid459.0PTEN, PAX5, SLPI, CSF1R, S100B, CDKN2A
31methionine459.0PTPRC, PTEN, CSF1R, CR1, S100B, SLPI
32testosterone45 61 24 1111.9SLPI, CDKN2A, S100B, PAX5, PTPRC, PTEN
33dexamethasone45 51 29 1111.9SLPI, CDKN2A, S100B, CD163, CSF1R, PTPRC
34vegf458.8CDKN2A, CSF1R, LGALS3, S100B, MPO, PTEN
35cysteine458.7LGALS3, PTPRC, CDKN2A, S100B, SLPI, CSF1R
36phospholipid458.7SLPI, PTEN, CR1, S100B
37lactate458.7MPO, SLPI, S100B, BCL6, LGALS3
38atp45 299.7SLPI, CSF1R, LGALS3, S100B, PTEN, CR1
39nitric oxide45 24 1110.7LGALS3, S100B, CDKN2A, CR1, PTEN, SLPI
40oxygen45 249.7S100B, CR1, LGALS3, CDKN2A, PTEN, SLPI
41oligonucleotide458.7IGH, SLPI, CDKN2A, CSF1R, LGALS3, PAX5
42hematoxylin458.6CDKN2A, PTEN, CR2, S100B, LGALS3, PTPRC
43lipid458.2CDKN2A, CSF1R, MS4A1, LGALS3, S100B, CD68
44cycloheximide457.9PTEN, PTPRC, BCL6, SLPI, CSF1R, CDKN2A
45estrogen457.8PTPRC, BCL6, PTEN, LGALS3, CSF1R, CR2
46retinoic acid45 248.7S100B, CDKN2A, CR1, PTEN, MPO, LGALS3
47tyrosine457.4CSF1R, BCL6, PAX5, SLPI, CR2, CR1
48calcium45 51 24 1110.3PTEN, PAX5, MS4A1, CDKN2A, SLPI, S100B
49serine457.2PTEN, MPO, PAX5, LGALS3, BCL6, CSF1R
50paraffin456.4CR2, CSF1R, BCL6, LGALS3, MS4A1, PAX5

GO Terms for genes affiliated with Histiocytic Sarcoma

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16Gene Ontology
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Cellular components related to Histiocytic Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.8CR2, MS4A1, PTPRC
2integral component of plasma membraneGO:0058878.7PTPRC, MS4A1, CSF1R, CR1, CD163
3extracellular vesicular exosomeGO:0700628.4SLPI, PTPRC, MPO, MS4A1, LGALS3, CR1
4plasma membraneGO:0058867.9PTEN, PTPRC, LGALS3, CSF1R, CR1, CR2

Biological processes related to Histiocytic Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of protein stabilityGO:0316479.9CDKN2A, PTEN
2B cell proliferationGO:0421009.8PTPRC, MS4A1, CR2
3long-term synaptic potentiationGO:0602919.6S100B, PTEN
4negative regulation of cell-matrix adhesionGO:0019539.3CDKN2A, BCL6
5innate immune responseGO:0450879.0S100B, CR2, CR1, CSF1R, LGALS3, PTEN

Products for genes affiliated with Histiocytic Sarcoma

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Sources for Histiocytic Sarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet