MCID: HST016
MIFTS: 45

Histiocytic Sarcoma

Categories: Cancer diseases, Blood diseases, Rare diseases

Aliases & Classifications for Histiocytic Sarcoma

MalaCards integrated aliases for Histiocytic Sarcoma:

Name: Histiocytic Sarcoma 55 69

Characteristics:

Orphanet epidemiological data:

55
histiocytic sarcoma
Age of onset: Adult;

Classifications:



External Ids:

Orphanet 55 ORPHA86896
MESH via Orphanet 42 D054747
UMLS via Orphanet 70 C0334663
ICD10 via Orphanet 33 C96.8
ICD10 32 C96.8
UMLS 69 C0334663

Summaries for Histiocytic Sarcoma

MalaCards based summary : Histiocytic Sarcoma is related to meningioma, familial and papillary carcinoma. An important gene associated with Histiocytic Sarcoma is CD163 (CD163 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and bone marrow, and related phenotypes are hematopoietic system and cellular

Related Diseases for Histiocytic Sarcoma

Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 30.3 CD68 MUC1 PTEN S100B
2 papillary carcinoma 30.0 BRAF LGALS3 MUC1
3 reticulum cell sarcoma 29.8 CR1 CR2 MUC1
4 langerhans cell histiocytosis 29.7 BRAF CD163 CSF1 S100B
5 histiocytosis 29.6 BRAF CD163 CSF1R FSCN1 S100B
6 interdigitating dendritic cell sarcoma 29.6 CD163 CR1 CR2 SPI1
7 histiocytic and dendritic cell cancer 29.6 CD163 CR1 CR2 SPI1
8 follicular lymphoma 29.5 BCL2 CR1 CR2 IGH MS4A1
9 rosai-dorfman disease 29.5 CD163 CR2 FSCN1 S100B
10 malignant histiocytosis 11.5
11 reticulosarcoma 11.1
12 sarcoma 10.9
13 central nervous system sarcoma 10.6 CD163 CD68
14 adult xanthogranuloma 10.6 CD163 CD68
15 lymphoplasmacyte-rich meningioma 10.6 CD163 CD68
16 localized hypertrophic neuropathy 10.6 MUC1 S100B
17 sclerosing perineurioma 10.6 MUC1 S100B
18 malignant giant cell tumor of soft parts 10.5 CD68 S100B
19 melanotic neurilemmoma 10.5 CD68 PTEN
20 intracranial cysts 10.5 MUC1 S100B
21 reticular perineurioma 10.5 MUC1 S100B
22 hydromyelia 10.5 PTEN S100B
23 brain sarcoma 10.5 CD163 CD68
24 non-functioning pituitary adenoma 10.5 MUC1 S100B
25 gemistocytic astrocytoma 10.5 PTEN S100B
26 epithelioid malignant peripheral nerve sheath tumor 10.5 MUC1 S100B
27 ossifying fibromyxoid tumor 10.4 MUC1 S100B
28 malignant peritoneal mesothelioma 10.4 CDKN2A MUC1
29 mixed type thymoma 10.4 PTEN S100B
30 fibrous meningioma 10.4 MUC1 S100B
31 polymorphous low-grade adenocarcinoma 10.4 LGALS3 MUC1 S100B
32 anaplastic ependymoma 10.4 MUC1 PTEN S100B
33 papillary tumor of the pineal region 10.4 BRAF MUC1
34 chordoid meningioma 10.4 MUC1 S100B
35 myxofibrosarcoma 10.4 MUC1 S100B
36 melanomatosis 10.4 CD68 CDKN2A
37 myopericytoma 10.4 BRAF S100B
38 ischemic fasciitis 10.3 CD68 CDKN2A MUC1
39 lymphohistiocytoid mesothelioma 10.3 CD68 CDKN2A
40 mucinous bronchioloalveolar adenocarcinoma 10.3 CDKN2A LGALS3 MUC1
41 tumor suppressor gene on chromosome 11 10.3 BRAF PTEN
42 squamous cell carcinoma of the larynx 10.3 BCL2 CDKN2A
43 parapharyngeal meningioma 10.3 CR1 CR2
44 spleen cancer 10.3 CD163 CD68 CR2
45 plasmablastic lymphoma 10.3 CDKN2A MS4A1 MUC1
46 lymphoma 10.3
47 follicular lymphoma 1 10.3 BCL2 IGH
48 spitz nevus 10.3 BRAF CDKN2A
49 eccrine porocarcinoma 10.3 MUC1 S100B
50 pleomorphic liposarcoma 10.3 CDKN2A MUC1 S100B

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to Histiocytic Sarcoma

Symptoms & Phenotypes for Histiocytic Sarcoma

MGI Mouse Phenotypes related to Histiocytic Sarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 CDKN2A CR2 CSF1 CSF1R HAVCR2 KMT2D
2 cellular MP:0005384 10.25 BCL2 BRAF CD163 CDKN2A CSF1 CSF1R
3 immune system MP:0005387 10.22 BCL2 BRAF CD163 CD68 CDKN2A CR2
4 homeostasis/metabolism MP:0005376 10.15 LGALS3 PTEN S100B SPI1 BCL2 BRAF
5 integument MP:0010771 9.86 BCL2 BRAF CDKN2A CSF1 CSF1R LGALS3
6 neoplasm MP:0002006 9.7 LGALS3 PTEN SPI1 BCL2 BRAF CDKN2A
7 respiratory system MP:0005388 9.5 BRAF CD163 CDKN2A CSF1 KMT2D LGALS3
8 skeleton MP:0005390 9.28 BRAF CD68 CDKN2A CSF1 CSF1R KMT2D

Drugs & Therapeutics for Histiocytic Sarcoma

Drugs for Histiocytic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Lenalidomide Approved Phase 2 191732-72-6 216326
4
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
5
Olaparib Approved Phase 2 763113-22-0 23725625
6 Anti-Infective Agents Phase 2
7 Angiogenesis Inhibitors Phase 2
8 Angiogenesis Modulating Agents Phase 2
9 Anti-Bacterial Agents Phase 2
10 Antifungal Agents Phase 2
11 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
12 Immunosuppressive Agents Phase 2
13 Antibiotics, Antitubercular Phase 2
14 tyrosine Nutraceutical Phase 2
15
Zidovudine Approved 30516-87-1 35370
16 Reverse Transcriptase Inhibitors
17 Nucleic Acid Synthesis Inhibitors
18 Anti-HIV Agents
19 Antimetabolites
20 Anti-Retroviral Agents
21 Antiviral Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of Lenalidomide for Adult Histiocyte Disorders Recruiting NCT02523040 Phase 2 Lenalidomide
2 Pediatric MATCH: Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders Recruiting NCT03155620 Phase 2 Ensartinib;Erdafitinib;Larotrectinib;Olaparib;PI3K/mTOR Inhibitor LY3023414;Selumetinib Sulfate;Tazemetostat;Vemurafenib
3 A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow Transplant Completed NCT00002284 Zidovudine

Search NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

Anatomical Context for Histiocytic Sarcoma

MalaCards organs/tissues related to Histiocytic Sarcoma:

38
Bone, Brain, Bone Marrow, B Cells, Spleen, Testes, Thyroid

Publications for Histiocytic Sarcoma

Articles related to Histiocytic Sarcoma:

(show top 50) (show all 294)
# Title Authors Year
1
Histiocytic sarcoma with bladder involvement: Case report and literature review. ( 29290317 )
2018
2
Simultaneous Brain and Lung Histiocytic Sarcoma Revealed on 18F-FDG PET/CT. ( 29189378 )
2018
3
Response to MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma. ( 29097496 )
2018
4
Morphological Distinction of Histiocytic Sarcoma from Other Tumor Types in Bernese Mountain Dogs and Flatcoated Retrievers. ( 29275293 )
2018
5
Histiocytic sarcoma: a population-based analysis of incidence, demographic disparities, and long-term outcomes. ( 29183888 )
2018
6
Primary cutaneous histiocytic sarcoma: A report of five cases with primary cutaneous involvement and review of the literature. ( 29414400 )
2018
7
A Case Report of Disseminated Canine Histiocytic Sarcoma in Trinidad and Tobago. ( 29351196 )
2018
8
Primary histiocytic sarcoma presenting as diffuse leptomeningeal disease: Case description and review of the literature. ( 28548244 )
2017
9
Histiocytic sarcoma in 14 miniature schnauzers - a new breed predisposition? ( 28543363 )
2017
10
Successful treatment of histiocytic sarcoma with cladribine and high-dose cytosine arabinoside in a child. ( 28247189 )
2017
11
Histiocytic Sarcoma with p16-Overexpression Presenting as Uterine Cervical Mass. ( 29263052 )
2017
12
Cutaneous Manifestation of Histiocytic Sarcoma: Presentation and Management. ( 28958257 )
2017
13
BRAF (V600E) expression in histiocytic sarcoma associated with splenic marginal zone lymphoma: a case report. ( 28376906 )
2017
14
Infection or Glioma? The False Dilemma of Primary Central Nervous System Histiocytic Sarcoma. ( 28711535 )
2017
15
Canine histiocytic sarcoma presenting as a target lesion on brain magnetic resonance imaging and as a solitary pulmonary mass. ( 28419635 )
2017
16
Invasive histiocytic sarcoma of the lumbar spine in a ferret (Mustela putorius furo). ( 28160308 )
2017
17
Pediatric intracerebral histiocytic sarcoma with rhabdoid features: Case report and literature review. ( 28748542 )
2017
18
Atypical cytologic presentation of a histiocytic sarcoma in a Cavalier King Charles Spaniel dog. ( 28381106 )
2017
19
Primary Histiocytic Sarcoma of the Brain in an African Hedgehog (Atelerix albiventris). ( 29169617 )
2017
20
Effect of dasatinib in a xenograft mouse model of canine histiocytic sarcoma and in vitro expression status of its potential target EPHA2. ( 28833247 )
2017
21
Retroperitoneal Bulky Histiocytic Sarcoma Successfully Treated with Induction Chemotherapy Followed by Curative Surgery. ( 28924109 )
2017
22
Efficacy of dacarbazine as a rescue agent for histiocytic sarcoma in dogs. ( 28419676 )
2017
23
Prior joint disease is associated with increased risk of periarticular histiocytic sarcoma in dogs. ( 28836371 )
2017
24
A 2-base insertion in exon 5 is a common mutation of the TP53 gene in dogs with histiocytic sarcoma. ( 28867679 )
2017
25
Dermoscopic characteristics of a cutaneous histiocytic sarcoma in a young patient. ( 28087030 )
2017
26
Comparisons among MRI signs, apparent diffusion coefficient, and fractional anisotropy in dogs with a solitary intracranial meningioma or histiocytic sarcoma. ( 28335080 )
2017
27
Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. ( 28621004 )
2017
28
Syndrome of inappropriate antidiuretic hormone secretion in a dog with a histiocytic sarcoma. ( 28698689 )
2017
29
Disseminated histiocytic sarcoma with hemophagocytosis in a rabbit. ( 28740033 )
2017
30
Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics. ( 28805986 )
2017
31
Primary Orbital Histiocytic Sarcoma in a Child Successfully Treated With Multiagent Chemotherapy. ( 27467374 )
2016
32
Disseminated Histiocytic Sarcoma in an African Hedgehog (Atelerix albiventris). ( 27720131 )
2016
33
Hepatic Involvement of Histiocytic Sarcoma: CT and MRI Findings. ( 27587965 )
2016
34
Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation. ( 27429816 )
2016
35
Disseminated histiocytic sarcoma in a child: a clinicopathological dichotomy with 8a88years survival. ( 27190112 )
2016
36
Histological and immunohistochemical features of histiocytic sarcoma in four domestic ferrets (Mustela putorius furo). ( 26965237 )
2016
37
Circulating let-7g is down-regulated in Bernese Mountain dogs with disseminated histiocytic sarcoma and carcinomasA -A a prospective study. ( 26792388 )
2016
38
Persistent Morbillivirus Infection Leads to Altered Cortactin Distribution in Histiocytic Sarcoma Cells with Decreased Cellular Migration Capacity. ( 27911942 )
2016
39
Primary histiocytic sarcoma of the uterine cervix: an extremely rare entity. ( 27828780 )
2016
40
Diffuse Histiocytic Sarcoma Involving the Choroid. ( 27541306 )
2016
41
Histiocytic sarcoma: secondary neoplasm or "transdifferentiation" in the setting of B-acute lymphoblastic leukemia. ( 27856472 )
2016
42
Microglioma in a child - a further case in support of the microglioma entity and distinction from histiocytic sarcoma. ( 27191913 )
2016
43
Diffuse leptomeningeal histiocytic sarcoma in the cerebrospinal fluid of 2 dogs. ( 26882507 )
2016
44
Evaluation of Costimulatory Molecules in Peripheral Blood Lymphocytes of Canine Patients with Histiocytic Sarcoma. ( 26901565 )
2016
45
Long-term treatment with the oncolytic ECHO-7 virus Rigvir of a melanoma stage IV M1c patient, a small cell lung cancer stage IIIA patient, and a histiocytic sarcoma stage IV patient-three case reports. ( 27457663 )
2016
46
Comparison of conventional magnetic resonance imaging and nonenhanced three dimensional time-of-flight magnetic resonance angiography findings between dogs with meningioma and dogs with intracranial histiocytic sarcoma: 19 cases (2010-2014). ( 27135670 )
2016
47
Cutaneous Histiocytic Sarcoma with Regional Lymph Node Metastasis in a Netherland Dwarf Rabbit (Oryctolagus cuniculus). ( 27890406 )
2016
48
Cooperation of BRAF(F595L) and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling. ( 26582644 )
2016
49
An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. ( 27325388 )
2016
50
Reduced angiogenic gene expression in morbillivirus-triggered oncolysis in a translational model for histiocytic sarcoma. ( 27860224 )
2016

Variations for Histiocytic Sarcoma

Expression for Histiocytic Sarcoma

Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for Histiocytic Sarcoma

Pathways related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 BCL2 BRAF CD68 CR1 CSF1 CSF1R
2
Show member pathways
13.16 BCL2 BRAF CSF1 CSF1R FSCN1 HAVCR2
3
Show member pathways
12.79 BCL2 BRAF CDKN2A CSF1R PTEN SPI1
4 12.52 BCL2 BRAF CDKN2A CSF1R PTEN SPI1
5
Show member pathways
12.02 BCL2 BRAF CSF1R PTEN
6 11.62 CD163 CD68 CSF1 MS4A1
7 11.52 BCL2 CSF1R SPI1
8 11.48 BCL2 BRAF CDKN2A PTEN
9 11.4 CR1 CR2 SPI1
10 11.34 CR1 CR2 CSF1 CSF1R MS4A1
11 10.89 CD163 CSF1 CSF1R MS4A1 SPI1
12 10.73 CD68 CSF1
13 10.61 LGALS3 S100B
14 10.59 CSF1 SPI1

GO Terms for Histiocytic Sarcoma

Cellular components related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 BCL2 CSF1 CSF1R KMT2D PTEN S100B
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 BRAF CSF1R HAVCR2 PTEN
3 immune system process GO:0002376 9.8 CR1 CR2 CSF1 CSF1R HAVCR2 LGALS3
4 hemopoiesis GO:0030097 9.72 BCL2 CSF1 CSF1R
5 regulation of protein stability GO:0031647 9.71 BCL2 CDKN2A PTEN
6 long-term synaptic potentiation GO:0060291 9.65 BRAF PTEN S100B
7 cell proliferation GO:0008283 9.63 BCL2 CSF1 CSF1R FSCN1 PTEN S100B
8 cellular response to ethanol GO:0071361 9.57 PTEN SPI1
9 complement receptor mediated signaling pathway GO:0002430 9.56 CR1 CR2
10 B cell proliferation GO:0042100 9.54 BCL2 CR2 MS4A1
11 regulation of axon regeneration GO:0048679 9.51 BRAF PTEN
12 lymphoid progenitor cell differentiation GO:0002320 9.49 BCL2 SPI1
13 macrophage colony-stimulating factor signaling pathway GO:0038145 9.43 CSF1 CSF1R
14 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189 9.4 HAVCR2 LGALS3
15 negative regulation of immunological synapse formation GO:2000521 9.26 HAVCR2 LGALS3
16 innate immune response GO:0045087 9.17 CR1 CR2 CSF1 CSF1R HAVCR2 LGALS3
17 macrophage differentiation GO:0030225 9.13 CSF1 CSF1R SPI1

Sources for Histiocytic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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