MCID: HST016
MIFTS: 34

Histiocytic Sarcoma malady

Categories: Cancer diseases, Blood diseases, Rare diseases

Aliases & Classifications for Histiocytic Sarcoma

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Sources:
51Orphanet, 65UMLS, 37MESH via Orphanet, 66UMLS via Orphanet, 28ICD10 via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Histiocytic Sarcoma:

Name: Histiocytic Sarcoma 51 65

Characteristics:

Orphanet epidemiological data:

51
histiocytic sarcoma:
Age of onset: Adult

Classifications:



External Ids:

Orphanet51 86896
MESH via Orphanet37 D054747
UMLS via Orphanet66 C0334663
ICD10 via Orphanet28 C96.8
ICD1027 C96.8
UMLS65 C0334663

Summaries for Histiocytic Sarcoma

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Wikipedia:68 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

MalaCards based summary: Histiocytic Sarcoma is related to granulomatous dermatitis and malignant histiocytosis. An important gene associated with Histiocytic Sarcoma is CD163 (CD163 Molecule), and among its related pathways are Dendritic Cells Developmental Lineage Pathway and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Affiliated tissues include thyroid, brain and bone, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Histiocytic Sarcoma

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Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1granulomatous dermatitis30.0CD163, CD68
2malignant histiocytosis11.6
3reticulosarcoma11.5
4leukemia10.3
5pancreatitis10.3
6plasmalogens synthesis deficiency isolated10.3CDKN2A, MS4A1
7primary malignant melanoma of the cervix10.2CDKN2A, PTEN
8gastric cancer10.2
9esophagitis10.2
10thyroiditis10.2
11hepatic osteogenic sarcoma10.2CDKN2A, PTEN
12ovary leiomyosarcoma10.2CDKN2A, PTEN
13cervical verrucous carcinoma10.2CDKN2A, PTEN
14benign mesenchymoma10.2CDKN2A, PTEN
15childhood pilocytic astrocytoma10.2CDKN2A, PTEN
16autosomal dominant charcot-marie-tooth disease type 2a210.1CDKN2A, PTEN
17vesicoureteral reflux10.1CDKN2A, PTEN
18lung cancer10.1
19breast cancer10.1
20pancreatic cancer10.1
21hepatitis10.1
22venous insufficiency10.1
23optic neuritis10.1
24azoospermia10.1
25down syndrome10.1
26neuritis10.1
27ovarian cancer10.1
28dermatitis10.1
29dyskeratosis congenita10.1
30adenocarcinoma10.1
31neuronitis10.1
32peritonitis10.1
33lupus erythematosus10.1
34encephalitis10.1
35endotheliitis10.1
36juvenile astrocytoma10.1CDKN2A, PTEN
37glottis neoplasm10.1CDKN2A, PTEN
38mannosidosis10.1CDKN2A, PTEN
39tracheal lymphoma10.1CDKN2A, PTEN
40littre gland carcinoma10.1CD163, CD68
41uterine corpus atypical polypoid adenomyoma10.1CD163, CD68
42pediatric meningioma10.1CD163, CD68
43central nervous system sarcoma10.1CD163, CD68
44dubin-johnson syndrome10.1CDKN2A, PTEN
45burning mouth syndrome10.0CD163, CD68
46lung combined large cell neuroendocrine carcinoma10.0CD68, CDKN2A
47malignant dermis tumor10.0CD163, CD68
48acantholytic variant squamous cell breast carcinoma10.0CD163, CD68
49anal paget's disease10.0CD68, CDKN2A
50peroxisomal disease10.0CD68, CDKN2A

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to histiocytic sarcoma

Symptoms for Histiocytic Sarcoma

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Drugs & Therapeutics for Histiocytic Sarcoma

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Drugs for Histiocytic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LenalidomideapprovedPhase 2674191732-72-6216326
Synonyms:
1-oxo-2-(2,6-Dioxopiperidin-3-yl)-4-aminoisoindoline
191732-72-6
3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
346670-73-3
443912-14-9
AC-914
AC1L50II
AKOS005146276
ALBB-015321
Bio-0168
C467567
CC 5013
CC-5013
CC-5013, Revlimid, Lenalidomide
CC5013
CDC 501
CDC-501
CDC-5013
CHEMBL848
CID216326
Celgene brand of lenalidomide
D04687
 
DB00480
EC-000.2340
ENMD-0997
I06-0831
IMID-1
IMID-5013
IMiD3
IMiD3 cpd
IMid-1
LS-184040
Lenalidomide
Lenalidomide (USAN/INN)
Lenalidomide [USAN]
MolPort-003-848-370
NCGC00167491-01
NSC747972
Revamid
Revimid
Revlimid
Revlimid (Celgene)
Revlimid (TN)
S1029_Selleck
STK639603
Thalidomide analog CC-5013
UNII-F0P408N6V4
lenalidomide
2Anti-Infective AgentsPhase 217220
3Angiogenesis Modulating AgentsPhase 23611
4Immunosuppressive AgentsPhase 210422
5Angiogenesis InhibitorsPhase 23688
6Anti-Bacterial AgentsPhase 29140
7Immunologic FactorsPhase 218483
8
Zidovudineapproved49130516-87-135370
Synonyms:
-Azido-3&prime
-deoxythymidine
1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine
3&prime
3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
3'-Azido-3'-deoxythymidine & Concanavalin A
3'-Azido-3'-deoxythymidine & Erythropoietin
3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19
3'-Azido-3'-deoxythymidine & Interleukin-1
3'-Azido-3'-deoxythymidine & Interleukin-2
3'-Azido-3'-deoxythymidine & Interleukin-6
3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6
3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon
3'-Azido-3'-deoxythymidine & Sho-Saiko-To
3'-Azido-3'-deoxythymidine (AIDS)
3'-Azido-3'deoxythymidine & Interferon .alpha.
3'-Azidothymidine
3'-Deoxy-3'-azidothymidine
3'-azido-3'-deoxythymidine, AZT
3-Azido-3-deoxythymidine
30516-87-1
399024-19-2
A2169_SIGMA
AC1L1TKL
AC1Q2OEK
AZT
AZT & CD4(178)-PE 40
AZT & Colony-stimulating factor 2
AZT & Concanavalin A (ConA)
AZT & EPO
AZT & GM-CSF
AZT & HPA
AZT & IFN.alpha.
AZT & IL-1
AZT & IL-2
AZT & IL-6
AZT & Interferon-.alpha.-2
AZT & Li & EPO
AZT & Li & GM-CSF
AZT & Li & IL-1
AZT & Li & IL-6
AZT & Lymphoblastoid Interferon
AZT & NP (from PHCA or HSA)
AZT & PM-19
AZT & SST
AZT & rIFN.alpha.2
AZT & rsCD4 & rIFN.alpha.A
AZT & rsT4
AZT & sCD4
AZT & srCD4
AZT (Antiviral)
AZT Antiviral
AZT TRANSPLACENTAL CARCINOGENESIS STUDY
AZT+PRO 140
AZT, Antiviral
Antiviral AZT
Apo-Zidovudine
Azidothymidine
Aztec
BB_NC-1012
BPBio1_000403
BRD-K72903603-001-04-6
BSPBio_000365
BSPBio_003153
BW A509U
BW-A 509U
BW-A-509U
BW-A509U
BWA 509U
BWA-509U
BWA509U
C07210
CCRIS 105
CHEBI:10110
CHEBI:127307
CHEMBL129
CID35370
CPD000058351
 
Compound S
Cpd S
D00413
D015215
DB00495
DRG-0004
DS-4152 & AZT
DivK1c_000524
HMS1921J20
HMS2090G11
HMS2092D06
HMS501K06
HSDB 6515
IDI1_000524
Interferon AD + 3'-azido-3'-deoxythymidine
Intron A & AZT
K7 [P Ti2 W10 O40]
KBio1_000524
KBio2_001828
KBio2_004396
KBio2_006964
KBio3_002653
KBioGR_000703
KBioSS_001828
LS-1159
Liposomal AZT-SN-1
Liposomal AZT-SN-3
MLS000028548
MLS001055351
MLS001076358
MLS002153202
MLS002222249
Met-SDF-1.beta. & AZT
Met-SDF-1.beta. & Zidovudine
MolPort-002-507-286
NCGC00023945-03
NCGC00023945-04
NCGC00023945-05
NCGC00023945-08
NCGC00178237-01
NCGC00178237-02
NINDS_000524
NSC 602670
Novo-Azt
PC-SOD+AZT
Prestwick3_000333
Propolis+AZT
Racemic Liposomal AZT
Retrovir
Retrovir (TN)
Retrovir(TM)
SAM002548971
SMR000058351
SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SPBio_000834
SPECTRUM1502109
STK801891
Spectrum2_000927
Spectrum3_001507
Spectrum4_000332
Spectrum5_001101
Spectrum_001348
UNII-4B9XT59T7S
ZDV
ZIDOVUDINE [AZT]
ZINC03779042
ZVD
Zidovudin
Zidovudina
Zidovudina [Spanish]
Zidovudine
Zidovudine (JAN/USP/INN)
Zidovudine EP III
Zidovudine [USAN:INN:BAN:JAN]
Zidovudine+PRO 140
Zidovudinum
Zidovudinum [Latin]
antiviral
azidodeoxythymidine
rIFN-beta seron & AZT
racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
zidovudin
zidovudine
9Reverse Transcriptase Inhibitors1656
10Nucleic Acid Synthesis Inhibitors3836
11Anti-Retroviral Agents2794
12Antimetabolites9454
13Antiviral Agents8071

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Lenalidomide for Adult Histiocyte DisordersRecruitingNCT02523040Phase 2
2A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow TransplantCompletedNCT00002284

Search NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

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Anatomical Context for Histiocytic Sarcoma

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MalaCards organs/tissues related to Histiocytic Sarcoma:

33
Thyroid, Brain, Bone, Bone marrow, Breast, Prostate, T cells

Animal Models for Histiocytic Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Histiocytic Sarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.4CD68, CDKN2A, HAVCR2, MS4A1, PTEN, TIMD4
2MP:00053877.1CD68, CDKN2A, HAVCR2, MS4A1, PTEN, TIMD4

Publications for Histiocytic Sarcoma

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Articles related to Histiocytic Sarcoma:

(show top 50)    (show all 227)
idTitleAuthorsYear
1
The Effect of Trochlear Dysplasia on Patellofemoral Biomechanics: A Cadaveric Study With Simulated Trochlear Deformities. (25740833)
2015
2
Management of Metastatic Apocrine Hidradenocarcinoma with Chemotherapy and Radiation. (26500736)
2015
3
Atypical aortic arch branching variants: A novel marker for thoracic aortic disease. (25802134)
2015
4
Scimitar syndrome with absent right pulmonary artery and severe pulmonary hypertension treated with coil occlusion of aortopulmonary collaterals in a term neonate. (25716044)
2015
5
Inflammatory myofibroblastic tumor: Clinical, morphological, immunohistochemical and molecular features of a pediatric case. (25149504)
2014
6
High prevalence of cerebral venous sinus thrombosis (CVST) as presentation of cystathionine beta-synthase deficiency in childhood: Molecular and clinical findings of Turkish probands. (24211323)
2014
7
A zebrafish model exemplifies the long preclinical period of motor neuron disease. (24970908)
2014
8
Peripheral Nerve Field Stimulation for Chronic Headache: 60 Cases and Long-Term Follow-Up. (24165152)
2013
9
IFNL3 mediates interaction between innate immune cells: Implications for hepatitis C virus pathogenesis. (24045339)
2013
10
Semireplication-competent vesicular stomatitis virus as a novel platform for oncolytic virotherapy. (22286341)
2012
11
A classic electrocardiographic manifestation of catecholaminergic polymorphic ventricular tachycardia. (21806698)
2012
12
Hypopituitarism caused by neurocysticercosis. (21289508)
2011
13
Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells. (21697760)
2011
14
Myoepithelial Carcinoma: A Rare Neoplasm of the Breast. (22590444)
2010
15
Cytotoxicity, acute and subchronic toxicity of ionic liquid, didecyldimethylammonium saccharinate, in rats. (20347908)
2010
16
Solute carrier family 2, member 9 and uric acid homeostasis. (19593129)
2009
17
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. (18483224)
2008
18
A case of essential thrombocythemia presenting with aortic thrombosis. (21318983)
2008
19
Association between the aggrecan gene variable number of tandem repeats polymorphism and intervertebral disc degeneration. (17632389)
2007
20
Clinicopathologic analysis of 92 cases of pancreatic cystic neoplasm]. (17535681)
2007
21
Pleomorphic epithelioid/clear cell malignant tumor of the uterus exhibiting both myoid and melanocytic differentiation--leiomyosarcoma or PEComa? A case report and a review of the literature]. (17821838)
2007
22
Using a protease-modulating dressing to treat necrobiosis lipoidica diabeticorum. (16521596)
2006
23
Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1. (15864539)
2005
24
Activator protein-1 in human male germ cell apoptosis. (15299089)
2004
25
Pasteurella multocida infection in heterophil-depleted chickens. (15529968)
2004
26
Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus. (14990737)
2004
27
Progress towards single-molecule DNA sequencing: a one color demonstration. (12668309)
2003
28
Methionine enkephalin suppresses metabolic activity of a leukemic cell line (NALM-1) and enhances CD10 expression. (12757739)
2003
29
Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation. (12153396)
2002
30
Transcriptional response of a human colon adenocarcinoma cell line to sodium butyrate. (11478796)
2001
31
Localization of NK1 and NK3 receptors in guinea-pig brain. (11179779)
2001
32
Targeting of chlorine E6 by EGF increasing its photodynamic activity in selective ways]. (11004908)
2000
33
Possible causes of acute pseudogout in older patients with osteoarthritis. (10991746)
2000
34
Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells. (10778990)
2000
35
Immunoreactive pancreatic Reg protein in sera from cystic fibrosis patients with and without pancreatic insufficiency. (10075963)
1999
36
Cytokine and prostaglandin E2 release from leukocytes in response to metal ions derived from different prosthetic materials: an in vitro study. (10619928)
1999
37
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. (9641677)
1998
38
Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane. (8845180)
1996
39
Sequence-based analysis of properdin deficiency: identification of point mutations in two phenotypic forms of an X-linked immunodeficiency. (8530058)
1995
40
Intracranial immature teratoma with syncytiotrophoblasts and tumor marker positive intestinal lining cells. (8599256)
1995
41
Expression of ras p21, p53 and c-erbB-2 in advanced breast cancer and response to first line hormonal therapy. (7577479)
1995
42
Splenic artery aneurysm in pregnancy. (7677710)
1995
43
Locking wrist with synovial chondromatosis: report of two cases. (7806803)
1994
44
Therapeutic response of herpes simplex virus-induced corneal edema to trifluridine in combination with immunosuppressive agents. (1907950)
1991
45
Chimeric mitochondrial genes expressed in the C male-sterile cytoplasm of maize. (1664299)
1991
46
Role of endocrinological factors in the pathogenesis of idiopathic edema. (6989020)
1980
47
Chronic actinic dermatitis--an idiopathic photosensitivity syndrome including actinic reticuloid and photosensitive eczema [proceedings]. (465324)
1979
48
Relation of Haemaphysalis spinigera larval infection rates and host viremia levels of Kyasanur Forest Disease virus. (5657515)
1968
49
Dacryocystitis. (13168869)
1954
50

Variations for Histiocytic Sarcoma

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Expression for genes affiliated with Histiocytic Sarcoma

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Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for genes affiliated with Histiocytic Sarcoma

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GO Terms for genes affiliated with Histiocytic Sarcoma

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Biological processes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of protein stabilityGO:00316479.7CDKN2A, PTEN
2protein stabilizationGO:00508219.5CDKN2A, PTEN
3positive regulation of ERK1 and ERK2 cascadeGO:00703749.3HAVCR2, PTEN

Sources for Histiocytic Sarcoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet