MCID: HST016
MIFTS: 40

Histiocytic Sarcoma malady

Categories: Cancer diseases, Blood diseases, Rare diseases

Aliases & Classifications for Histiocytic Sarcoma

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Sources:
51Orphanet, 65UMLS, 37MESH via Orphanet, 66UMLS via Orphanet, 28ICD10 via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Histiocytic Sarcoma:

Name: Histiocytic Sarcoma 51 65

Characteristics:

Orphanet epidemiological data:

51
histiocytic sarcoma:
Age of onset: Adult

Classifications:



External Ids:

Orphanet51 86896
MESH via Orphanet37 D054747
UMLS via Orphanet66 C0334663
ICD10 via Orphanet28 C96.8
ICD1027 C96.8
UMLS65 C0334663

Summaries for Histiocytic Sarcoma

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Wikipedia:68 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

MalaCards based summary: Histiocytic Sarcoma is related to malignant histiocytosis and reticulosarcoma, and has symptoms including hepatomegaly An important gene associated with Histiocytic Sarcoma is CD163 (CD163 Molecule), and among its related pathways are Dendritic Cells Developmental Lineage Pathway and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Affiliated tissues include brain, thyroid and bone, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Histiocytic Sarcoma

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Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1malignant histiocytosis11.5
2reticulosarcoma11.1
3sarcoma10.9
4plasmalogens synthesis deficiency isolated10.4CDKN2A, MS4A1
5lymphoma10.3
6primary malignant melanoma of the cervix10.3CDKN2A, PTEN
7hepatic osteogenic sarcoma10.3CDKN2A, PTEN
8leukemia10.3
9ovary leiomyosarcoma10.3CDKN2A, PTEN
10cervical verrucous carcinoma10.3CDKN2A, PTEN
11benign mesenchymoma10.3CDKN2A, PTEN
12childhood pilocytic astrocytoma10.2CDKN2A, PTEN
13autosomal dominant charcot-marie-tooth disease type 2a210.2CDKN2A, PTEN
14vesicoureteral reflux10.2CDKN2A, PTEN
15juvenile astrocytoma10.2CDKN2A, PTEN
16lymphoblastic leukemia10.2
17histiocytosis10.2
18glottis neoplasm10.1CDKN2A, PTEN
19follicular lymphoma10.1
20mannosidosis10.1CDKN2A, PTEN
21tracheal lymphoma10.1CDKN2A, PTEN
22littre gland carcinoma10.1CD163, CD68
23thyroiditis10.1
24uterine corpus atypical polypoid adenomyoma10.1CD163, CD68
25pediatric meningioma10.1CD163, CD68
26central nervous system sarcoma10.1CD163, CD68
27dubin-johnson syndrome10.1CDKN2A, PTEN
28b-cell lymphomas10.0
29hematopoietic stem cell transplantation10.0
30thrombocytopenia10.0
31burning mouth syndrome10.0CD163, CD68
32lung combined large cell neuroendocrine carcinoma10.0CD68, CDKN2A
33malignant dermis tumor10.0CD163, CD68
34acantholytic variant squamous cell breast carcinoma10.0CD163, CD68
35anal paget's disease10.0CD68, CDKN2A
36granulomatous dermatitis10.0CD163, CD68
37peroxisomal disease10.0CD68, CDKN2A
38hypothalamic disease10.0CDKN2A, PTEN
39gastrointestinal carcinoma10.0CD68, CDKN2A
40cerebritis10.0
41precursor b-cell acute lymphoblastic leukemia10.0
42otomycosis10.0CD68, HAVCR2
43meninges hemangiopericytoma10.0CD68, CDKN2A
44adult pulmonary langerhans cell histiocytosis9.9CDKN2A, IGH
45extraosseous ewing's sarcoma9.9CD163, CD68
46childhood oligodendroglioma9.9CDKN2A, PTEN
47plexiform schwannoma9.9CD68, PTEN
48chronic myelomonocytic leukemia9.9
49diffuse large b-cell lymphoma9.9
50langerhans-cell histiocytosis9.9

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to histiocytic sarcoma

Symptoms for Histiocytic Sarcoma

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UMLS symptoms related to Histiocytic Sarcoma:


hepatomegaly

Drugs & Therapeutics for Histiocytic Sarcoma

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Drugs for Histiocytic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LenalidomideapprovedPhase 2674191732-72-6216326
Synonyms:
1-oxo-2-(2,6-Dioxopiperidin-3-yl)-4-aminoisoindoline
191732-72-6
3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
346670-73-3
443912-14-9
AC-914
AC1L50II
AKOS005146276
ALBB-015321
Bio-0168
C467567
CC 5013
CC-5013
CC-5013, Revlimid, Lenalidomide
CC5013
CDC 501
CDC-501
CDC-5013
CHEMBL848
CID216326
Celgene brand of lenalidomide
D04687
 
DB00480
EC-000.2340
ENMD-0997
I06-0831
IMID-1
IMID-5013
IMiD3
IMiD3 cpd
IMid-1
LS-184040
Lenalidomide
Lenalidomide (USAN/INN)
Lenalidomide [USAN]
MolPort-003-848-370
NCGC00167491-01
NSC747972
Revamid
Revimid
Revlimid
Revlimid (Celgene)
Revlimid (TN)
S1029_Selleck
STK639603
Thalidomide analog CC-5013
UNII-F0P408N6V4
lenalidomide
2Anti-Infective AgentsPhase 217220
3Angiogenesis Modulating AgentsPhase 23611
4Immunosuppressive AgentsPhase 210422
5Angiogenesis InhibitorsPhase 23688
6Anti-Bacterial AgentsPhase 29140
7Immunologic FactorsPhase 218483
8
Zidovudineapproved49130516-87-135370
Synonyms:
-Azido-3&prime
-deoxythymidine
1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine
3&prime
3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
3'-Azido-3'-deoxythymidine & Concanavalin A
3'-Azido-3'-deoxythymidine & Erythropoietin
3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19
3'-Azido-3'-deoxythymidine & Interleukin-1
3'-Azido-3'-deoxythymidine & Interleukin-2
3'-Azido-3'-deoxythymidine & Interleukin-6
3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6
3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon
3'-Azido-3'-deoxythymidine & Sho-Saiko-To
3'-Azido-3'-deoxythymidine (AIDS)
3'-Azido-3'deoxythymidine & Interferon .alpha.
3'-Azidothymidine
3'-Deoxy-3'-azidothymidine
3'-azido-3'-deoxythymidine, AZT
3-Azido-3-deoxythymidine
30516-87-1
399024-19-2
A2169_SIGMA
AC1L1TKL
AC1Q2OEK
AZT
AZT & CD4(178)-PE 40
AZT & Colony-stimulating factor 2
AZT & Concanavalin A (ConA)
AZT & EPO
AZT & GM-CSF
AZT & HPA
AZT & IFN.alpha.
AZT & IL-1
AZT & IL-2
AZT & IL-6
AZT & Interferon-.alpha.-2
AZT & Li & EPO
AZT & Li & GM-CSF
AZT & Li & IL-1
AZT & Li & IL-6
AZT & Lymphoblastoid Interferon
AZT & NP (from PHCA or HSA)
AZT & PM-19
AZT & SST
AZT & rIFN.alpha.2
AZT & rsCD4 & rIFN.alpha.A
AZT & rsT4
AZT & sCD4
AZT & srCD4
AZT (Antiviral)
AZT Antiviral
AZT TRANSPLACENTAL CARCINOGENESIS STUDY
AZT+PRO 140
AZT, Antiviral
Antiviral AZT
Apo-Zidovudine
Azidothymidine
Aztec
BB_NC-1012
BPBio1_000403
BRD-K72903603-001-04-6
BSPBio_000365
BSPBio_003153
BW A509U
BW-A 509U
BW-A-509U
BW-A509U
BWA 509U
BWA-509U
BWA509U
C07210
CCRIS 105
CHEBI:10110
CHEBI:127307
CHEMBL129
CID35370
CPD000058351
 
Compound S
Cpd S
D00413
D015215
DB00495
DRG-0004
DS-4152 & AZT
DivK1c_000524
HMS1921J20
HMS2090G11
HMS2092D06
HMS501K06
HSDB 6515
IDI1_000524
Interferon AD + 3'-azido-3'-deoxythymidine
Intron A & AZT
K7 [P Ti2 W10 O40]
KBio1_000524
KBio2_001828
KBio2_004396
KBio2_006964
KBio3_002653
KBioGR_000703
KBioSS_001828
LS-1159
Liposomal AZT-SN-1
Liposomal AZT-SN-3
MLS000028548
MLS001055351
MLS001076358
MLS002153202
MLS002222249
Met-SDF-1.beta. & AZT
Met-SDF-1.beta. & Zidovudine
MolPort-002-507-286
NCGC00023945-03
NCGC00023945-04
NCGC00023945-05
NCGC00023945-08
NCGC00178237-01
NCGC00178237-02
NINDS_000524
NSC 602670
Novo-Azt
PC-SOD+AZT
Prestwick3_000333
Propolis+AZT
Racemic Liposomal AZT
Retrovir
Retrovir (TN)
Retrovir(TM)
SAM002548971
SMR000058351
SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SPBio_000834
SPECTRUM1502109
STK801891
Spectrum2_000927
Spectrum3_001507
Spectrum4_000332
Spectrum5_001101
Spectrum_001348
UNII-4B9XT59T7S
ZDV
ZIDOVUDINE [AZT]
ZINC03779042
ZVD
Zidovudin
Zidovudina
Zidovudina [Spanish]
Zidovudine
Zidovudine (JAN/USP/INN)
Zidovudine EP III
Zidovudine [USAN:INN:BAN:JAN]
Zidovudine+PRO 140
Zidovudinum
Zidovudinum [Latin]
antiviral
azidodeoxythymidine
rIFN-beta seron & AZT
racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
zidovudin
zidovudine
9Reverse Transcriptase Inhibitors1656
10Nucleic Acid Synthesis Inhibitors3836
11Anti-Retroviral Agents2794
12Antimetabolites9454
13Antiviral Agents8071

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Lenalidomide for Adult Histiocyte DisordersRecruitingNCT02523040Phase 2
2A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow TransplantCompletedNCT00002284

Search NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

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Anatomical Context for Histiocytic Sarcoma

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MalaCards organs/tissues related to Histiocytic Sarcoma:

33
Brain, Thyroid, Bone, Breast, Bone marrow, Lung, Heart

Animal Models for Histiocytic Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Histiocytic Sarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.4CD68, CDKN2A, HAVCR2, MS4A1, PTEN, TIMD4
2MP:00053877.1CD68, CDKN2A, HAVCR2, MS4A1, PTEN, TIMD4

Publications for Histiocytic Sarcoma

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Articles related to Histiocytic Sarcoma:

(show top 50)    (show all 245)
idTitleAuthorsYear
1
Microglioma in a child - a further case in support of the microglioma entity and distinction from histiocytic sarcoma. (27191913)
2016
2
Two cases of histiocytic sarcoma with BCL2 translocations and occult or subsequent follicular lymphoma. (27134111)
2016
3
Fine needle aspiration cytology of histiocytic sarcoma with dendritic cell differentiation: a case of transdifferentiation from low-grade follicular lymphoma. (25993973)
2015
4
Concomitant follicular lymphoma and histiocytic sarcoma: A rare progression, trans-differentiation or co-occurrence? (26549087)
2015
5
Histiocytic sarcoma with central nervous system involvement in dogs: 19 cases (2006-2012). (25711602)
2015
6
Coexistence of tuberculosis with histiocytic sarcoma: A rare association. (26458659)
2015
7
Survivin suppressor (YM155) enhances chemotherapeutic efficacy against canine histiocytic sarcoma in murine transplantation models. (25744435)
2015
8
Enhanced CT and FDG PET/CT in Histiocytic Sarcoma of the Pericardium. (26545021)
2015
9
Isolated cranial nerve palsies may point to primary histiocytic sarcoma. (25123571)
2014
10
A case of CD68 negative histiocytic sarcoma of axilla masquerading as metastatic breast cancer. (25031040)
2014
11
Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice. (24827933)
2014
12
Successful treatment of histiocytic sarcoma with induction chemotherapy consisting of dose-escalated CHOP plus etoposide and upfront consolidation auto-transplantation. (25062797)
2014
13
Follicular lymphoma transformation into histiocytic sarcoma: indications for a common neoplastic progenitor. (24850291)
2014
14
Primary gastric histiocytic sarcoma reminiscent of inflammatory pseudotumor: a case report with review of the literature. (25013428)
2014
15
Primary endobronchial histiocytic sarcoma in a case of papillary carcinoma thyroid: a complex clinical scenario. (25321458)
2014
16
Unusual presentation of a rare cancer: histiocytic sarcoma in the brain 16 years after treatment for acute lymphoblastic leukemia. (22997353)
2013
17
Pulmonary histiocytic sarcoma in a rabbit. (23909927)
2013
18
Identification of dasatinib as an in vitro potent growth inhibitor of canine histiocytic sarcoma cells. (23369384)
2013
19
Peri-articular histiocytic sarcoma and previous joint disease in Bernese Mountain Dogs. (23458888)
2013
20
What is your diagnosis? Disseminated histiocytic sarcoma. (24134574)
2013
21
Erythrophagocytosis Enhances Heme-Dependent Cytotoxicity of Antimalarial Drugs in Canine Histiocytic Sarcoma Cell Line DH82. (24065080)
2013
22
Long-term remission after autologous stem-cell transplantation for relapsed histiocytic sarcoma. (22876158)
2012
23
Histiocytic sarcoma of the central nervous system: a challenging diagnosis. (21186180)
2012
24
Coexistence of Langerhans cell histiocytosis, Rosai-Dorfman disease and splenic lymphoma with fatal outcome after rapid development of histiocytic sarcoma of the liver. (23043641)
2012
25
Histiocytic sarcoma - targeted therapy: novel therapeutic options? A series of 4 cases. (22846978)
2012
26
Histiocytic sarcoma transdifferentiated from follicular lymphoma presenting as a cutaneous tumor. (21883369)
2011
27
Autologous hematopoietic stem-cell transplantation in combination with thalidomide as treatment for histiocytic sarcoma: a case report and review of the literature. (21220616)
2011
28
Histiocytic sarcoma involving lymph nodes: imaging appearance on gallium-67 and F-18 FDG PET/CT. (21552013)
2011
29
The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. (20656318)
2010
30
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. (20548287)
2010
31
Histiocytic sarcoma with interdigitating dendritic cell differentiation: a case report with fine needle aspiration cytology and review of literature. (19845032)
2010
32
Malignant histiocytoses/disseminated histiocytic sarcoma with hemophagocytic syndrome in a patient with mediastinal germ cell tumor. (18987551)
2009
33
Brain tumours in two Bactrian camels: a histiocytic sarcoma and a meningioma. (19483210)
2009
34
MR imaging of histiocytic sarcoma of the canine brain. (19400464)
2009
35
Histiocytic sarcoma: identification of its histiocytic origin using immunohistochemistry. (18239326)
2008
36
Histiocytic sarcoma localised in the thyroid: a case report. (18386009)
2008
37
Histiocytic sarcoma: PET-CT evaluation of a rare entity. (18982475)
2008
38
An atypical case of histiocytic sarcoma in a Wistar rat (Rattus norvegicus). (18222080)
2008
39
CCNU for the treatment of dogs with histiocytic sarcoma. (17338159)
2007
40
Canine ocular histiocytic sarcoma. (17445080)
2007
41
Histiocytic sarcoma of the spleen in flat-coated retrievers with regenerative anaemia and hypoproteinaemia. (16782856)
2006
42
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. (16697958)
2006
43
Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin. (15050956)
2004
44
Primary histiocytic sarcoma of the spleen associated with erythrophagocytic histiocytosis. (12747473)
2003
45
Histiocytic sarcoma of the spleen associated with hypoalbuminemia, hypo gamma-globulinemia and thrombocytopenia as a possibly unique clinical entity--report of three cases. (9720731)
1998
46
Morphological characteristics of a transplantable histiocytic sarcoma (HS-J) in F344 rats and appearance of renal tubular hyaline droplets in HS-J-bearing rats. (9076602)
1997
47
Histiocytic sarcoma. (8082925)
1994
48
Histiocytic sarcoma of the scrotum in a rat. (6281570)
1982
49
Malignant lymphoma of true histiocytic origin: histiocytic sarcoma. A morphological, ultrastructural, immunological, cytochemical and clinical study of 10 cases. (7281492)
1981
50

Variations for Histiocytic Sarcoma

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Expression for genes affiliated with Histiocytic Sarcoma

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Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for genes affiliated with Histiocytic Sarcoma

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GO Terms for genes affiliated with Histiocytic Sarcoma

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Biological processes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of protein stabilityGO:00316479.7CDKN2A, PTEN
2protein stabilizationGO:00508219.5CDKN2A, PTEN
3positive regulation of ERK1 and ERK2 cascadeGO:00703749.3HAVCR2, PTEN

Sources for Histiocytic Sarcoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet