MCID: HST016
MIFTS: 40

Histiocytic Sarcoma malady

Categories: Cancer diseases, Blood diseases, Rare diseases

Aliases & Classifications for Histiocytic Sarcoma

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Sources:
30ICD10, 31ICD10 via Orphanet, 40MESH via Orphanet, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Histiocytic Sarcoma:

Name: Histiocytic Sarcoma 54 68

Characteristics:

Orphanet epidemiological data:

54
histiocytic sarcoma:
Age of onset: Adult

Classifications:



External Ids:

Orphanet54 ORPHA86896
MESH via Orphanet40 D054747
UMLS via Orphanet69 C0334663
ICD10 via Orphanet31 C96.8
ICD1030 C96.8

Summaries for Histiocytic Sarcoma

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Wikipedia:71 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

MalaCards based summary: Histiocytic Sarcoma is related to autoimmune lymphoproliferative syndrome and malignant histiocytosis, and has symptoms including hepatomegaly An important gene associated with Histiocytic Sarcoma is CD163 (CD163 Molecule), and among its related pathways are Advanced glycosylation endproduct receptor signaling and LDL Oxidation in Atherogenesis. Affiliated tissues include brain, thyroid and bone, and related mouse phenotypes are integument and hematopoietic system.

Related Diseases for Histiocytic Sarcoma

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Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune lymphoproliferative syndrome29.4CD68, MUC1, PTEN, S100B
2malignant histiocytosis11.4
3reticulosarcoma10.9
4sarcoma10.8
5logopenic progressive aphasia10.7MUC1, S100B
6intermediate dend syndrome10.7MUC1, S100B
72q33.1 microdeletion syndrome10.7BRAF, MUC1
8lyme disease - neurological complications10.7MUC1, S100B
9anaplastic oligoastrocytoma10.7MUC1, S100B
10relapsing epidemic typhus10.7MUC1, S100B
11lymphangiosarcoma10.7MUC1, S100B
12pituitary deficiency due to rathke's pouch cysts10.6MUC1, S100B
13hypotonia10.6PTEN, S100B
14chondroblastoma10.6MUC1, S100B
15subacute leukemia10.6MUC1, S100B
16pseudoglandular variant testicular seminoma10.6MUC1, S100B
17pediculus humanus capitis infestation10.6MUC1, S100B
18lumbar plexus neoplasm10.6MUC1, S100B
19external ear disease10.6MUC1, S100B
20subependymal giant cell astrocytoma10.6MUC1, S100B
21pulmonary venoocclusive disease10.6BRAF, S100B
22bartholin's gland benign neoplasm10.6MUC1, S100B
23eccrine papillary adenoma10.5MUC1, S100B
24skin sarcoma10.5BRAF, MUC1
25pineoblastoma10.5BRAF, MUC1
26breast papillary carcinoma10.5MUC1, S100B
27polyomavirus allograft nephropathy10.5LGALS3, MUC1, S100B
28split hand split foot malformation autosomal recessive10.5BRAF, CDKN2A
29gallbladder adenoma10.5MUC1, S100B
30temporal lobe neoplasm10.5CD163, CD68
31epicardium cancer10.4BRAF, MUC1, S100B
32penile urethral cancer10.4CR1, CR2
33extracranial neuroblastoma10.4CDKN2A, MUC1
34skin glomangioma10.4MUC1, S100B
35luteoma10.4CD163, CD68
36intravascular fasciitis10.4CD68, MUC1
37microcystic meningioma10.4CD163, CD68
38diffuse pulmonary fibrosis10.4CD68, S100B
3910.4CD68, PTEN
40white platelet syndrome10.4CDKN2A, MS4A1, MUC1
41rhizomelic chondrodysplasia punctata10.4BRAF, CD163, CSF1
42ovarian surface papilloma10.4BRAF, MUC1
43frontotemporal dementia and/or amyotrophic lateral sclerosis 410.4BRAF, LGALS3, PTEN
44prostate stromal sarcoma10.4CR1, CR2
45penis verrucous carcinoma10.4CDKN2A, MUC1, S100B
46sclerosing liposarcoma10.4CDKN2A, MUC1, S100B
47central centrifugal cicatricial alopecia10.3CDKN2A, MUC1, S100B
48richter's syndrome10.3CDKN2A, LGALS3, MUC1
49angioma hereditary neurocutaneous10.3CR1, CR2
50mucinoses10.3CD163, CSF1, CSF1R

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to histiocytic sarcoma

Symptoms & Phenotypes for Histiocytic Sarcoma

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UMLS symptoms related to Histiocytic Sarcoma:


hepatomegaly

MGI Mouse Phenotypes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3BRAF, CDKN2A, CSF1, CSF1R, LGALS3, PTEN
2MP:00053977.4BRAF, CD68, CDKN2A, CR2, CSF1, CSF1R
3MP:00053876.5BRAF, CD68, CDKN2A, CR2, CSF1, CSF1R

Drugs & Therapeutics for Histiocytic Sarcoma

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Drugs for Histiocytic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LenalidomideapprovedPhase 2718191732-72-6216326
Synonyms:
1-oxo-2-(2,6-Dioxopiperidin-3-yl)-4-aminoisoindoline
191732-72-6
3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
346670-73-3
443912-14-9
AC-914
AC1L50II
AKOS005146276
ALBB-015321
Bio-0168
C467567
CC 5013
CC-5013
CC-5013, Revlimid, Lenalidomide
CC5013
CDC 501
CDC-501
CDC-5013
CHEMBL848
CID216326
Celgene brand of lenalidomide
D04687
 
DB00480
EC-000.2340
ENMD-0997
I06-0831
IMID-1
IMID-5013
IMiD3
IMiD3 cpd
IMid-1
LS-184040
Lenalidomide
Lenalidomide (USAN/INN)
Lenalidomide [USAN]
MolPort-003-848-370
NCGC00167491-01
NSC747972
Revamid
Revimid
Revlimid
Revlimid (Celgene)
Revlimid (TN)
S1029_Selleck
STK639603
Thalidomide analog CC-5013
UNII-F0P408N6V4
lenalidomide
2Anti-Infective AgentsPhase 221402
3Angiogenesis InhibitorsPhase 24143
4Immunosuppressive AgentsPhase 212770
5Anti-Bacterial AgentsPhase 210884
6Angiogenesis Modulating AgentsPhase 24072
7
Zidovudineapproved49430516-87-135370
Synonyms:
-Azido-3&prime
-deoxythymidine
1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine
3&prime
3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
3'-Azido-3'-deoxythymidine & Concanavalin A
3'-Azido-3'-deoxythymidine & Erythropoietin
3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19
3'-Azido-3'-deoxythymidine & Interleukin-1
3'-Azido-3'-deoxythymidine & Interleukin-2
3'-Azido-3'-deoxythymidine & Interleukin-6
3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6
3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon
3'-Azido-3'-deoxythymidine & Sho-Saiko-To
3'-Azido-3'-deoxythymidine (AIDS)
3'-Azido-3'deoxythymidine & Interferon .alpha.
3'-Azidothymidine
3'-Deoxy-3'-azidothymidine
3'-azido-3'-deoxythymidine, AZT
3-Azido-3-deoxythymidine
30516-87-1
399024-19-2
A2169_SIGMA
AC1L1TKL
AC1Q2OEK
AZT
AZT & CD4(178)-PE 40
AZT & Colony-stimulating factor 2
AZT & Concanavalin A (ConA)
AZT & EPO
AZT & GM-CSF
AZT & HPA
AZT & IFN.alpha.
AZT & IL-1
AZT & IL-2
AZT & IL-6
AZT & Interferon-.alpha.-2
AZT & Li & EPO
AZT & Li & GM-CSF
AZT & Li & IL-1
AZT & Li & IL-6
AZT & Lymphoblastoid Interferon
AZT & NP (from PHCA or HSA)
AZT & PM-19
AZT & SST
AZT & rIFN.alpha.2
AZT & rsCD4 & rIFN.alpha.A
AZT & rsT4
AZT & sCD4
AZT & srCD4
AZT (Antiviral)
AZT Antiviral
AZT TRANSPLACENTAL CARCINOGENESIS STUDY
AZT+PRO 140
AZT, Antiviral
Antiviral AZT
Apo-Zidovudine
Azidothymidine
Aztec
BB_NC-1012
BPBio1_000403
BRD-K72903603-001-04-6
BSPBio_000365
BSPBio_003153
BW A509U
BW-A 509U
BW-A-509U
BW-A509U
BWA 509U
BWA-509U
BWA509U
C07210
CCRIS 105
CHEBI:10110
CHEBI:127307
CHEMBL129
CID35370
 
CPD000058351
Compound S
Cpd S
D00413
D015215
DB00495
DRG-0004
DS-4152 & AZT
DivK1c_000524
HMS1921J20
HMS2090G11
HMS2092D06
HMS501K06
HSDB 6515
IDI1_000524
Interferon AD + 3'-azido-3'-deoxythymidine
Intron A & AZT
K7 [P Ti2 W10 O40]
KBio1_000524
KBio2_001828
KBio2_004396
KBio2_006964
KBio3_002653
KBioGR_000703
KBioSS_001828
LS-1159
Liposomal AZT-SN-1
Liposomal AZT-SN-3
MLS000028548
MLS001055351
MLS001076358
MLS002153202
MLS002222249
Met-SDF-1.beta. & AZT
Met-SDF-1.beta. & Zidovudine
MolPort-002-507-286
NCGC00023945-03
NCGC00023945-04
NCGC00023945-05
NCGC00023945-08
NCGC00178237-01
NCGC00178237-02
NINDS_000524
NSC 602670
Novo-Azt
PC-SOD+AZT
Prestwick3_000333
Propolis+AZT
Racemic Liposomal AZT
Retrovir
Retrovir (TN)
Retrovir(TM)
SAM002548971
SMR000058351
SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SPBio_000834
SPECTRUM1502109
STK801891
Spectrum2_000927
Spectrum3_001507
Spectrum4_000332
Spectrum5_001101
Spectrum_001348
UNII-4B9XT59T7S
ZDV
ZIDOVUDINE [AZT]
ZINC03779042
ZVD
Zidovudin
Zidovudina
Zidovudina [Spanish]
Zidovudine (JAN/USP/INN)
Zidovudine EP III
Zidovudine [USAN:INN:BAN:JAN]
Zidovudine+PRO 140
Zidovudinum
Zidovudinum [Latin]
antiviral
azidodeoxythymidine
rIFN-beta seron & AZT
racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
zidovudin
zidovudine
8Reverse Transcriptase Inhibitors1880
9Nucleic Acid Synthesis Inhibitors4855
10Anti-HIV Agents3100
11Antimetabolites11774
12Anti-Retroviral Agents3232
13Antiviral Agents9732

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Lenalidomide for Adult Histiocyte DisordersRecruitingNCT02523040Phase 2
2A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow TransplantCompletedNCT00002284

Search NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

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Anatomical Context for Histiocytic Sarcoma

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MalaCards organs/tissues related to Histiocytic Sarcoma:

36
Brain, Thyroid, Bone, Bone marrow, B cells, Spleen, Lymph node

Publications for Histiocytic Sarcoma

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Articles related to Histiocytic Sarcoma:

(show top 50)    (show all 265)
idTitleAuthorsYear
1
Dermoscopic characteristics of a cutaneous histiocytic sarcoma in a young patient. (28087030)
2017
2
Apoptosis inhibitor of macrophage (AIM) reduces cell number in canine histiocytic sarcoma cell lines. (27246397)
2016
3
Microglioma in a child - a further case in support of the microglioma entity and distinction from histiocytic sarcoma. (27191913)
2016
4
Two cases of histiocytic sarcoma with BCL2 translocations and occult or subsequent follicular lymphoma. (27134111)
2016
5
Cooperation of BRAF(F595L) and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling. (26582644)
2016
6
Hepatic Involvement of Histiocytic Sarcoma: CT and MRI Findings. (27587965)
2016
7
Diffuse Histiocytic Sarcoma Involving the Choroid. (27541306)
2016
8
An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. (27325388)
2016
9
Diffuse leptomeningeal histiocytic sarcoma in the cerebrospinal fluid of 2 dogs. (26882507)
2016
10
Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation. (27429816)
2016
11
High-dose methotrexate-based chemotherapy as treatment for histiocytic sarcoma of the central nervous system. (26727454)
2016
12
Evaluation of Costimulatory Molecules in Peripheral Blood Lymphocytes of Canine Patients with Histiocytic Sarcoma. (26901565)
2016
13
Disseminated histiocytic sarcoma in a child: a clinicopathological dichotomy with 8a88years survival. (27190112)
2016
14
Risk Factors Associated with Development of Histiocytic Sarcoma in Bernese Mountain Dogs. (27160025)
2016
15
Cutaneous Histiocytic Sarcoma with Regional Lymph Node Metastasis in a Netherland Dwarf Rabbit (Oryctolagus cuniculus). (27890406)
2016
16
Comparison of conventional magnetic resonance imaging and nonenhanced three dimensional time-of-flight magnetic resonance angiography findings between dogs with meningioma and dogs with intracranial histiocytic sarcoma: 19 cases (2010-2014). (27135670)
2016
17
Reduced angiogenic gene expression in morbillivirus-triggered oncolysis in a translational model for histiocytic sarcoma. (27860224)
2016
18
Histiocytic sarcoma: secondary neoplasm or "transdifferentiation" in the setting of B-acute lymphoblastic leukemia. (27856472)
2016
19
Long-term treatment with the oncolytic ECHO-7 virus Rigvir of a melanoma stage IV M1c patient, a small cell lung cancer stage IIIA patient, and a histiocytic sarcoma stage IV patient-three case reports. (27457663)
2016
20
Histiocytic Sarcoma in a Kidney Transplant Patient: A Case Report and Review of the Literature. (27795864)
2016
21
Primary Orbital Histiocytic Sarcoma in a Child Successfully Treated With Multiagent Chemotherapy. (27467374)
2016
22
Somatic mutations in histiocytic sarcoma identified by next generation sequencing. (27259537)
2016
23
Histological and immunohistochemical features of histiocytic sarcoma in four domestic ferrets (Mustela putorius furo). (26965237)
2016
24
Disseminated Histiocytic Sarcoma in an African Hedgehog (Atelerix albiventris). (27720131)
2016
25
Persistent Morbillivirus Infection Leads to Altered Cortactin Distribution in Histiocytic Sarcoma Cells with Decreased Cellular Migration Capacity. (27911942)
2016
26
Primary histiocytic sarcoma of the uterine cervix: an extremely rare entity. (27828780)
2016
27
Circulating let-7g is down-regulated in Bernese Mountain dogs with disseminated histiocytic sarcoma and carcinomasA -A a prospective study. (26792388)
2016
28
Clinical prognostic factors in canine histiocytic sarcoma. (27334037)
2016
29
Histiocytic Sarcoma as a Secondary Malignancy: Pathobiology, Diagnosis, and Treatment. (26990812)
2016
30
SYSTEMIC HISTIOCYTIC SARCOMA IN A COMMON HIPPOPOTAMUS (HIPPOPOTAMUS AMPHIBIUS). (27468044)
2016
31
A rare case of paediatric histiocytic sarcoma of the maxilla and mandible. (27090951)
2016
32
Sudden unexpected death from an undiagnosed histiocytic sarcoma in an adolescent female. (27465385)
2016
33
Gastric histiocytic sarcoma in a dog. (27925661)
2016
34
NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-I_B signaling. (27105514)
2016
35
Concomitant follicular lymphoma and histiocytic sarcoma: A rare progression, trans-differentiation or co-occurrence? (26549087)
2015
36
Histiocytic sarcoma with central nervous system involvement in dogs: 19 cases (2006-2012). (25711602)
2015
37
Survivin suppressor (YM155) enhances chemotherapeutic efficacy against canine histiocytic sarcoma in murine transplantation models. (25744435)
2015
38
Enhanced CT and FDG PET/CT in Histiocytic Sarcoma of the Pericardium. (26545021)
2015
39
Histiocytic sarcoma combined with acute monocytic leukemia: a case report. (26187047)
2015
40
Successful Treatment of Multifocal Histiocytic Sarcoma Occurring after Renal Transplantation with Cladribine, High-Dose Cytarabine, G-CSF, and Mitoxantrone (CLAG-M) Followed by Allogeneic Hematopoietic Stem Cell Transplantation. (26167311)
2015
41
Hypercalcemia and parathyroid hormone-related peptide expression in a dog with thyroid carcinoma and histiocytic sarcoma. (25707928)
2015
42
A Case of G-CSF-Producing Histiocytic Sarcoma of the Stomach. (25785346)
2015
43
Passage-dependent morphological and phenotypical changes of a canine histiocytic sarcoma cell line (DH82 cells). (25534080)
2015
44
Post mortem computed tomography and core needle biopsy in comparison to autopsy in eleven Bernese mountain dogs with histiocytic sarcoma. (26329821)
2015
45
Histiocytic Sarcoma Originating in the Lung in a 16-Year-Old Male. (26106007)
2015
46
Fine needle aspiration cytology of histiocytic sarcoma with dendritic cell differentiation: a case of transdifferentiation from low-grade follicular lymphoma. (25993973)
2015
47
Coexistence of tuberculosis with histiocytic sarcoma: A rare association. (26458659)
2015
48
Histiocytic sarcoma; case report of a rare disease in a kidney transplant recipient. (26312238)
2015
49
Primary cerebral histiocytic sarcoma in childhood: a case report of protracted survival and review of the literature. (26174618)
2015
50
Primary Central Nervous System Histiocytic Sarcoma Arising After Precursor B-Cell Acute Lymphoblastic Leukemia. (26574666)
2015

Variations for Histiocytic Sarcoma

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Expression for genes affiliated with Histiocytic Sarcoma

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Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for genes affiliated with Histiocytic Sarcoma

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GO Terms for genes affiliated with Histiocytic Sarcoma

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Cellular components related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CSF1-CSF1R complexGO:19906829.8CSF1, CSF1R

Biological processes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of immunological synapse formationGO:200052110.6HAVCR2, LGALS3
2negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:200118910.6HAVCR2, LGALS3
3complement receptor mediated signaling pathwayGO:000243010.4CR1, CR2
4macrophage colony-stimulating factor signaling pathwayGO:003814510.4CSF1, CSF1R
5macrophage differentiationGO:003022510.3CSF1, CSF1R
6long-term synaptic potentiationGO:006029110.2BRAF, PTEN, S100B
7positive regulation of osteoclast differentiationGO:00456729.9CSF1, CSF1R
8regulation of axon regenerationGO:00486799.9BRAF, PTEN
9positive regulation of ERK1 and ERK2 cascadeGO:00703749.6BRAF, CSF1R, HAVCR2, PTEN
10cell proliferationGO:00082839.1CSF1, CSF1R, FSCN1, PTEN, S100B
11innate immune responseGO:00450878.8CR1, CR2, CSF1, CSF1R, HAVCR2, LGALS3

Sources for Histiocytic Sarcoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet