MCID: HST009
MIFTS: 49

Histiocytoma malady

Summaries for Histiocytoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 A histiocytoma is a tumour consisting of histiocytes. Histiocytes are cells that are a part of the... more...

MalaCards: Histiocytoma, also known as cutaneous fibrous histiocytoma, is related to fibrous histiocytoma and cutaneous fibrous histiocytoma. An important gene associated with Histiocytoma is ATF1 (activating transcription factor 1), and among its related pathways are Immune System and Rho Family GTPases. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Related mouse phenotypes are normal and immune system.

Aliases & Classifications for Histiocytoma

Sources:
61UMLS, 8Disease Ontology, 10DISEASES, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

histiocytoma 8 10
cutaneous fibrous histiocytoma 61
histiocytoma, nos 8


External Ids:

Disease Ontology8 DOID:4231
NCIt40 C35765
MeSH35 D051642

Related Diseases for Histiocytoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma31.9CD34, CREB1, FOXO4
2cutaneous fibrous histiocytoma30.9CD34, CD68, FOXO4
3dermatofibrosarcoma protuberans30.3ACTC1, CD34, DES, F13A1, S100A1, S100B
4dermatofibrosarcoma30.3MDM2, FOXO4
5dedifferentiated liposarcoma30.3MDM2, DES
6fibrous meningioma30.2S100B
7squamous cell carcinoma30.1FOXO4
8myxoid liposarcoma30.1ATF1, MDM2
9adenocarcinoma30.0VIM, MDM2, CREB1, F13A1, CD34, ACTC1
10angiosarcoma30.0SERPINA3, ACTC1, CD34, VIM
11spindle cell sarcoma30.0ACTC1, DES, S100B, VIM
12rhabdoid tumor30.0VIM, DES, MYOD1, ACTC1
13neurofibromatosis30.0CREB1
14hemangioendothelioma30.0CD34
15desmoid tumor30.0DES, ACTC1
16fibromatosis29.7VIM, S100A1, DES, CD34, ACTC1
17acute leukemia29.7IL6R, CD34, CREB1, FOXO4
18colorectal cancer29.7MDM2, CD34, IL6R, EREG
19rosai-dorfman disease29.7CD163, S100B
20tuberous sclerosis29.7F13A1, S100B, VIM
21pheochromocytoma29.7IL6R, CREB1
22pleomorphic malignant fibrous histiocytoma10.6
23diaphyseal medullary stenosis with malignant fibrous histiocytoma10.4
24bone osteosarcoma10.4
25pleomorphic undifferentiated sarcoma10.4
26soft tissue sarcoma10.3
27burn scar10.2
28benign deep fibrous histiocytoma10.2
29generalized eruptive histiocytosis10.2
30malignant skin fibrous histiocytoma10.2
31leukemoid reaction10.2
32malignant fibrous histiocytoma of bone10.1
33hypoglycemia10.1
34malignant histiocytosis10.1
35myxofibrosarcoma10.1
36tenosynovial giant cell tumor10.0
37meningothelial meningioma10.0
38pleomorphic liposarcoma10.0
39inflammatory liposarcoma10.0
40lymphosarcoma10.0
41fibrous dysplasia10.0
42enchondroma10.0
43histiocytoma, angiomatoid fibrous, somatic10.0
44epithelioid hemangioendothelioma10.0
45melanoma10.0FOXO4, S100A1, S100B, HSPB2, VIM, MDM2
46sarcoma10.0ACTC1, CD34, CD163, MYOD1, DES, F13A1
47burkitt's lymphoma10.0S100A1, MDM2, CREB1, ATF1, F13A1, MYOD1
48leiomyosarcoma10.0S100B, VIM, ACTC1, CD34, MYOD1, DES
49hemangiopericytoma10.0ACTC1, CD34, DES, F13A1, MDM2, S100A1
50giant cell tumor10.0VIM, S100B, F13A1, DES, ACTC1, SERPINA3

Graphical network of the top 20 diseases related to Histiocytoma:



Diseases related to histiocytoma

Clinical Features for Histiocytoma

Drugs & Therapeutics for Histiocytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Histiocytoma

Drug clinical trials:

Search ClinicalTrials for Histiocytoma

Search NIH Clinical Center for Histiocytoma

Search CenterWatch for Histiocytoma

Genetic Tests for Histiocytoma

Anatomical Context for Histiocytoma

Animal Models for Histiocytoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Histiocytoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.7MDM2, ATF1, FOXO4, S100A1, S100B, MYOD1
2MP:000538710.7MDM2, EREG, IL6R, CD34, CD68, ATF1
3MP:000536910.5HSPB2, ACTC1, MYOD1, CREB1, MDM2
4MP:000538510.4ACTC1, VIM, MYOD1, DES, F13A1, CREB1

Publications for Histiocytoma

Sources:
51PubMed
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Articles related to Histiocytoma:

(show top 50)    (show all 784)
idTitleAuthorsYear
1
Regression of canine cutaneous histiocytoma is associated with an orchestrated expression of matrix metalloproteinases. (23582970)
2013
2
Epithelioid cell histiocytoma: broad differential diagnostic considerations. (22168147)
2012
3
Recurrent malignant fibrous histiocytoma in psoas muscle: a case report. (22977703)
2012
4
Malignant fibrous histiocytoma of the spermatic cord: case report and literature review. (22613448)
2012
5
Generalized eruptive histiocytomas and rosai-dorfman disease presenting concurrently in a patient with myelodysplastic syndrome. (22916314)
2012
6
Malignant fibrous histiocytoma arising from a hydronephrotic kidney: a case report and review of the literature. (22542387)
2012
7
Mast cell tumour and cutaneous histiocytoma excision wound healing in general practice. (21896021)
2011
8
Hypervascular retroperitoneal mass in a patient with Fever and leucocytosis - contrast-enhanced ultrasonographic findings in a case of inflammatory malignant fibrous histiocytoma. (20408125)
2011
9
Protein kinase CI' in tumorigenesis of human malignant fibrous histiocytoma. (21822543)
2011
10
A case of primary malignant fibrous histiocytoma of the duodenum. (22096696)
2011
11
Cytodiagnosis of benign fibrous histiocytoma of rib and diagnostic dilemma: a case report. (20014125)
2010
12
Malignant fibrous histiocytoma-case report. (22190809)
2010
13
Cutaneous malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma) arising in a chronic scalp ulcer of a patient with non-bullous congenital ichthyosiform erythroderma. (18435726)
2009
14
Tyrosine kinase inhibitors in treatment of fibrous histiocytoma. (19300420)
2009
15
Malignant fibrous histiocytoma of the larynx in a patient with neurofibromatosis type 1. (18681209)
2008
16
Radiation induced malignant histiocytoma of the contralateral breast following treatment of breast cancer: a case report and review of the literature. (19014612)
2008
17
Primary hepatic malignant fibrous histiocytoma: a case report and review of the literature. (17701913)
2007
18
Malignant fibrous histiocytoma following radiation therapy and chemotherapy for Hodgkin's lymphoma. (17380442)
2007
19
Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing. (16501844)
2006
20
Soft-tissue malignant fibrous histiocytoma (high-grade undifferentiated pleomorphic sarcoma) arising in a desmoid tumor in a patient with Milroy's disease. (16437208)
2006
21
Giant cell type of primary intracranial malignant fibrous histiocytoma: a case report. (18095121)
2006
22
Interleukin-8 producing malignant fibrous histiocytoma with prolonged fever. (17460768)
2006
23
Aneurysmal fibrous histiocytoma in a 10-year-old girl with leukemia. (17156007)
2006
24
Benign fibrous histiocytoma of the pterygopalatine fossa with intracranial extension. (16200478)
2006
25
Malignant fibrous histiocytoma, malignant melanoma and squamous cell carcinoma arising from different areas in an adult. (16440931)
2005
26
Malignant fibrous histiocytoma of the tongue: review of the literature and report of a case. (15789329)
2005
27
Malignant fibrous histiocytoma of the pharynx. (15728001)
2005
28
Can pancreaticoduodenectomy be used to palliate selective metastatic malignancies? Case report of malignant fibrous histiocytoma. (16137587)
2005
29
Benign fibrous histiocytoma of the distal radius with congenital dislocation of the radial head: a case report. (15872408)
2005
30
Benign fibrous histiocytoma of the mandible. (15689235)
2005
31
Malignant fibrous histiocytoma of the trachea. (15952323)
2005
32
Expression profiling using tissue microarray in 211 malignant fibrous histiocytomas confirms the prognostic value of Ki-67. (15309631)
2004
33
Myxofibrosarcoma of the breast as an unusual variant of malignant fibrous histiocytoma: report of a case. (15338347)
2004
34
Calvarial malignant fibrous histiocytoma. (15472438)
2004
35
Malignant fibrous histiocytoma masquerading as germ cell tumor by producing beta-human chorionic gonadotropin and neuron-specific enolase. (12946774)
2003
36
Expression of smooth muscle markers in so called malignant fibrous histiocytomas. (12944549)
2003
37
Atypical fibrous histiocytoma of the scrotum. (15018121)
2003
38
Atypical fibrous histiocytoma of the skin: clinicopathologic analysis of 59 cases with evidence of infrequent metastasis. (11756767)
2002
39
Cytogenetic and molecular genetic analysis of a pediatric pleomorphic sarcoma reveals similarities to adult malignant fibrous histiocytoma. (9169031)
1997
40
Cutaneous fibrous histiocytoma with osteoclast-like giant cells. (8863988)
1996
41
A unique non-Langerhans cell histiocytosis with some features of generalized eruptive histiocytoma. (8034797)
1994
42
Cellular benign fibrous histiocytoma. Clinicopathologic analysis of 74 cases of a distinctive variant of cutaneous fibrous histiocytoma with frequent recurrence. (8017561)
1994
43
Palisading cutaneous fibrous histiocytoma. An immunohistochemical study demonstrating differentiation from dermal dendrocytes. (8311187)
1993
44
A case of inflammatory malignant fibrous histiocytoma of the colon. (7690726)
1993
45
Malignant fibrous histiocytoma of the aorta complicated by anuria. (1318066)
1992
46
Inflammatory fibrous histiocytoma presenting leukemoid reaction. (2546130)
1989
47
Palisading cutaneous fibrous histiocytoma. (3029199)
1986
48
Malignant fibrous histiocytoma of bone associated with focal hemangiopericytomatous pattern. (6274137)
1981
49
Cytology of canine cutaneous round cell tumors. Mast cell tumor, histiocytoma, lymphosarcoma and transmissible venereal tumor. (228464)
1979
50
Malignant fibrous histiocytoma of bone. (199869)
1977

Genetic Variations for Histiocytoma

Expression for genes affiliated with Histiocytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Histiocytoma

Search GEO for disease gene expression data for Histiocytoma.

Pathways for genes affiliated with Histiocytoma

Sources:
54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Pathways related to Histiocytoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6FOXO4, MDM2, CREB1, S100B, ATF1, CD34
2
Hide members
10.6ATF1, CREB1, VIM, MDM2, IL6R, DES
3
Hide members
10.6ATF1, CREB1, MDM2, FOXO4, EREG
4
Hide members
10.6MDM2, CREB1, EREG, FOXO4, S100B
5
Hide members
10.5ACTC1, DES, VIM
6
Hide members
10.5MDM2, FOXO4, CREB1, EREG
7
Hide members
10.5EREG, CREB1, MDM2, FOXO4
810.5MYOD1, ATF1, CREB1
910.5MYOD1, FOXO4, CREB1
10
Hide members
10.5CREB1, ATF1
1110.5CREB1, FOXO4

Compounds for genes affiliated with Histiocytoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
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Compounds related to Histiocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1progesterone45 60 29 11 2415.2MDM2, S100A1, S100B, ATF1, F13A1, CD34
2paraffin4511.2CD163, DES, MYOD1, MDM2, S100B, CD34
3calcium45 50 11 2414.1ATF1, MYOD1, S100B, MDM2, CREB1, F13A1
4vegf4511.1HSPB2, S100B, MDM2, CREB1, DES, MYOD1
5iron45 2412.1F13A1, S100B, HSPB2, CD163, ACTC1, VIM
6retinoic acid45 2412.1CREB1, SERPINA3, ACTC1, IL6R, CD34, S100A1
7steroid4511.1MDM2, CREB1, SERPINA3, DES, MYOD1, IL6R
8tyrosine4511.1MYOD1, DES, CREB1, HSPB2, S100A1, S100B
9oligonucleotide4511.1VIM, HSPB2, MDM2, CREB1, ATF1, F13A1
10hematoxylin4511.1VIM, S100A1, ACTC1, F13A1, CD34, S100B
1112-o-tetradecanoylphorbol 13-acetate4511.1IL6R, HSPB2, CD34, DES, CREB1, VIM
12b 7234511.0S100A1, VIM, DES, ACTC1, S100B, F13A1
13testosterone45 60 11 2414.0CREB1, S100B, MDM2, VIM, ACTC1, IL6R
14s 1004511.0ACTC1, DES, F13A1, S100B, VIM
15arginine4511.0SERPINA3, S100B, IL6R, MDM2, VIM, HSPB2
16mucicarmine4511.0S100A1, S100B, DES, ACTC1, VIM
17glycogen45 2412.0CREB1, MDM2, ACTC1, IL6R, FOXO4
18cyclic amp45 2412.0DES, VIM, MDM2, S100B, CREB1, MYOD1
19reticulin4511.0VIM, ACTC1, DES
20cysteine4511.0MDM2, DES, CREB1, MYOD1, S100A1, S100B
21orcein4511.0VIM, S100B, ACTC1, DES
22acetylcholine45 50 29 11 2415.0MYOD1, CREB1, S100A1, HSPB2, SERPINA3
23creatinine4511.0SERPINA3, MYOD1, ACTC1, IL6R, HSPB2
24estradiol45 11 2413.0MDM2, SERPINA3, CREB1, DES, IL6R, VIM
25silver4511.0S100A1, F13A1, DES, CD34, SERPINA3
26wortmannin4511.0MDM2, IL6R, CREB1, FOXO4, S100B, VIM
27dexamethasone45 50 29 1114.0CD163, S100B, CREB1, IL6R, MDM2
28estrogen4511.0MYOD1, F13A1
29glutamine4510.9S100B, HSPB2, VIM, CREB1, F13A1, IL6R
30lysine4510.9VIM, DES, F13A1, MDM2, HSPB2, MYOD1
31serine4510.9HSPB2, S100B, ATF1, DES, MYOD1, SERPINA3
32zinc45 2411.9MDM2, CREB1, MYOD1, SERPINA3, IL6R, S100A1
332-methoxyethanol4510.9S100A1, ACTC1, VIM
34leucine4510.9CREB1, S100B, VIM, ATF1, MYOD1, SERPINA3
35glucose4510.9IL6R, ACTC1, SERPINA3
36toluidine4510.9DES, S100A1, VIM
37lipid4510.9CD163, VIM, SERPINA3, HSPB2, S100B, CREB1
38heparin45 29 11 2413.8S100B, F13A1, SERPINA3, DES
39oxygen45 2411.8SERPINA3, HSPB2, S100B, MDM2, DES, ACTC1
40procollagen4510.8F13A1
41azathioprine45 50 2 1113.8DES, VIM, CREB1, MYOD1
42biotin45 11 2412.8VIM, ACTC1, DES, S100A1
43bromodeoxyuridine4510.7MYOD1, DES, S100B, VIM
44actomyosin4510.7VIM, S100A1, ACTC1
45actinomycin d4510.7MDM2, DES, CREB1, VIM, MYOD1
46formaldehyde45 2411.6ACTC1, DES, S100B, VIM
47imatinib45 50 1112.6DES, ACTC1, MDM2, S100B
48valine4510.6VIM, S100B, MDM2, SERPINA3
49forskolin45 50 1112.5VIM, EREG, S100B, ATF1, CREB1
50thapsigargin45 6011.3MDM2, HSPB2, CREB1, ATF1

GO Terms for genes affiliated with Histiocytoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Histiocytoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1neurotrophin TRK receptor signaling pathwayGO:04801110.8EREG, ATF1, CREB1, FOXO4, MDM2
2phosphatidylinositol-mediated signalingGO:04801510.7EREG, CREB1, MDM2, FOXO4
3innate immune responseGO:04508710.7S100B, FOXO4, MDM2, CREB1, ATF1, EREG
4acute-phase responseGO:00695310.7SERPINA3, IL6R, CD163
5muscle filament slidingGO:03004910.6DES, VIM, ACTC1
6fibroblast growth factor receptor signaling pathwayGO:00854310.5EREG, CREB1, MDM2, FOXO4
7negative regulation of smooth muscle cell differentiationGO:05115110.5EREG, FOXO4
8Fc-epsilon receptor signaling pathwayGO:03809510.4FOXO4, MDM2, CREB1, EREG
9epidermal growth factor receptor signaling pathwayGO:00717310.2EREG, CREB1, MDM2, FOXO4

Molecular functions related to Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.6SERPINA3, VIM, HSPB2, S100B, S100A1, FOXO4
2S100 protein bindingGO:04454810.5S100A1, S100B
3identical protein bindingGO:04280210.3VIM, S100B, S100A1, MDM2, DES

Products for genes affiliated with Histiocytoma

  • Antibodies
  • Proteins
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  • Antibodies

Sources for Histiocytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet