MCID: HST009
MIFTS: 56

Histiocytoma malady

Summaries for Histiocytoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A histiocytoma is a tumour consisting of histiocytes. Histiocytes are cells that are a part of the... more...

MalaCards: Histiocytoma, also known as cutaneous fibrous histiocytoma, is related to fibrous histiocytoma and cutaneous fibrous histiocytoma. An important gene associated with Histiocytoma is ATF1 (activating transcription factor 1), and among its related pathways are Immune System and Rho Family GTPases. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung, and related mouse phenotypes are normal and immune system.

Aliases & Classifications for Histiocytoma

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60UMLS, 8Disease Ontology, 10DISEASES, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

histiocytoma 8 10
cutaneous fibrous histiocytoma 60
histiocytoma, nos 8


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Disease Ontology8 DOID:4231
NCIt39 C35765
MeSH34 D051642

Related Diseases for Histiocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma31.8CD34, CREB1, FOXO4
2cutaneous fibrous histiocytoma30.9CD34, CD68, FOXO4
3sarcoma30.8ACTC1, CD34, CD163, MYOD1, DES, F13A1
4malignant fibroxanthoma30.6CD34, MFHAS1, FOXO4
5osteosarcoma30.5MDM2, CREB1, MYOD1, IL6R
6liposarcoma30.5CD34, DES, MDM2, VIM
7histiocytosis30.4S100B, CD163, CD68
8fibrosarcoma30.3VIM, MDM2, DES, CD34, ACTC1
9dermatofibrosarcoma30.3MDM2, FOXO4
10leiomyosarcoma30.2S100B, VIM, ACTC1, CD34, MYOD1, DES
11epithelioid sarcoma30.2VIM, CD34
12meningioma30.1VIM, S100B, S100A1, CD68, CD34
13fibrous meningioma30.1S100B
14hemangiopericytoma30.0ACTC1, CD34, DES, F13A1, MDM2, S100A1
15giant cell tumor30.0VIM, S100B, F13A1, DES, ACTC1, SERPINA3
16hemangioma30.0F13A1, CD163, CD68, CD34, ACTC1
17leukemia30.0MDM2, CREB1, ATF1, CD34, IL6R, SERPINA3
18langerhans-cell histiocytosis30.0S100B, S100A1, F13A1
19retinoblastoma30.0MYOD1, CREB1, MDM2
20squamous cell carcinoma30.0FOXO4
21myxoid liposarcoma30.0ATF1, MDM2
22melanoma29.9FOXO4, S100A1, S100B, HSPB2, VIM, MDM2
23adenocarcinoma29.9VIM, MDM2, CREB1, F13A1, CD34, ACTC1
24angiosarcoma29.9SERPINA3, ACTC1, CD34, VIM
25spindle cell sarcoma29.9ACTC1, DES, S100B, VIM
26hepatocellular carcinoma29.9IL6R, CD34, F13A1, ATF1, CREB1, MDM2
27chordoma29.9DES, S100A1, S100B, VIM
28neurofibromatosis29.9CREB1
29breast cancer29.7VIM, HSPB2, S100A1, MDM2, IL6R, ACTC1
30rhabdomyosarcoma29.7VIM, S100B, S100A1, MDM2, DES, MYOD1
31leiomyoma29.7VIM, S100B, S100A1, DES, CD34, ACTC1
32perineurioma29.7VIM, S100B, CD34
33acute leukemia29.7IL6R, CD34, CREB1, FOXO4
34colorectal cancer29.7MDM2, CD34, IL6R, EREG
35fasciitis29.7ACTC1
36tuberous sclerosis29.7F13A1, S100B, VIM
37pheochromocytoma29.7IL6R, CREB1
38non-hodgkin lymphoma29.7MDM2, MYOD1, CD34, IL6R
39pulmonary embolism29.7F13A1
40malignant fibrous histiocytoma of bone10.8
41diaphyseal medullary stenosis with malignant fibrous histiocytoma10.4
42bone osteosarcoma10.3
43hepatitis10.3
44hepatitis a10.2
45burn scar10.2
46burns10.2
47malignant skin fibrous histiocytoma10.2
48leukemoid reaction10.2
49benign deep fibrous histiocytoma10.2
50sclerosing hemangioma10.2

Graphical network of the top 20 diseases related to Histiocytoma:



Diseases related to histiocytoma

Clinical Features for Histiocytoma

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Drugs & Therapeutics for Histiocytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Histiocytoma

Drug clinical trials:

Search ClinicalTrials for Histiocytoma

Search NIH Clinical Center for Histiocytoma

Search CenterWatch for Histiocytoma

Genetic Tests for Histiocytoma

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Anatomical Context for Histiocytoma

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32MalaCards
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MalaCards organs/tissues related to Histiocytoma:

32
Bone, Breast, Lung, Heart, Skin, Liver, Spleen, Pancreas, Colon, Kidney, Ovary, Thyroid, T cells, Cervix, Trachea, Tongue, Smooth muscle, Thymus, Prostate, Adrenal gland, Brain, Lymph node, Skeletal muscle, Endothelial, Uterus, Monocytes, Testis, Bone marrow, Testes

Animal Models for Histiocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Histiocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.7MDM2, ATF1, FOXO4, S100A1, S100B, MYOD1
2MP:000538710.7MDM2, EREG, IL6R, CD34, CD68, ATF1
3MP:000536910.5HSPB2, ACTC1, MYOD1, CREB1, MDM2
4MP:000538510.4ACTC1, VIM, MYOD1, DES, F13A1, CREB1

Publications for Histiocytoma

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50PubMed
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Articles related to Histiocytoma:

(show top 50)    (show all 784)
idTitleAuthorsYear
1
Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma. (23982330)
2013
2
A case of cutaneous malignant fibrous histiocytoma with multiple organ metastases. (23347814)
2013
3
Solitary epithelioid histiocytoma (reticulohistiocytoma) of the glans penis. (22777481)
2012
4
Malignant fibrous histiocytoma: changing perceptions and management challenges. (22677489)
2012
5
Simultaneous squamous cell carcinoma with primary malignant fibrous histiocytoma of the larynx: a case report. (22307748)
2012
6
A p53 gene mutation in malignant fibrous histiocytoma associated with bone infarction. (22041521)
2011
7
Primary malignant fibrous histiocytoma of the liver: CT findings in five histopathological proven patients. (21287171)
2011
8
Recurrence of a simultaneous tumor of the parotid gland and scalp skin malignant fibrous histiocytoma. (21959458)
2011
9
Malignant fibrous histiocytoma of the spine: a series of 13 clinical case reports and review of 17 published cases. (21343863)
2011
10
Imaging characteristics of angiomatoid fibrous histiocytoma of bone. (20803341)
2011
11
Malignant fibrous histiocytoma of the heart. (21854443)
2011
12
Secondary malignant fibrous histiocytoma of thigh with surface ulceration following radiotherapy for carcinoma cervix. (20922400)
2011
13
Undifferentiated pleomorphic sarcoma (malignant fibrous histiocytoma) of the head in a dog. (20877156)
2011
14
A clinical and histopathological study of 122 cases of dermatofibroma (benign fibrous histiocytoma). (21747617)
2011
15
Malignant fibrous histiocytoma of the greater omentum. (19863985)
2011
16
Primary malignant fibrous histiocytoma of the pancreas: benefit of the multidisciplinary approach. (20446353)
2010
17
Malignant fibrous histiocytoma of the mandible. (20981646)
2010
18
Surgical treatment of benign fibrous histiocytoma as a form of intraspinal extradural tumor at lumbar spine. (21165318)
2010
19
Malignant fibrous histiocytoma complicating nephrogenic systemic fibrosis post liver transplantation. (19769682)
2009
20
Malignant fibrous histiocytoma of larynx with giant cell: case report and histological-clinical considerations. (19690778)
2009
21
Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. (19596951)
2009
22
Right hemi-reconstruction of the left atrium using two equine pericardial patches for recurrent malignant fibrous histiocytoma: report of a case. (19639440)
2009
23
Benign fibrous histiocytoma of the lumbar vertebrae. (18985340)
2009
24
Angiomatoid fibrous histiocytoma: a review with recent genetic findings. (18251589)
2008
25
3D-Histological evaluation of surgery in dermatofibrosarcoma protuberans and malignant fibrous histiocytoma: differences in growth patterns and outcome. (17716851)
2008
26
Benign fibrous histiocytoma of the bladder. (19675769)
2007
27
Alterations of the retinoblastoma and p16 pathway correlate with promoter methylation in malignant fibrous histiocytomas. (17094467)
2006
28
Primary malignant fibrous histiocytoma of the pancreas: a case with K-ras mutation and a review of the literature. (16416164)
2005
29
Histological vascular invasion by tumors is a risk factor for distant metastasis in malignant fibrous histiocytoma. (15865088)
2005
30
Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p. (15731925)
2005
31
A single-team experience of limb sparing approach in adults with high-grade malignant fibrous histiocytoma. (16142374)
2005
32
Malignant fibrous histiocytoma in a chronic burn scar: a rare case report and review of the literature. (15475153)
2004
33
Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity. (15221942)
2004
34
Benign fibrous histiocytoma of prepuce in the mule. (15129924)
2004
35
Diaphyseal medullary stenosis with malignant fibrous histiocytoma: further evidence for loss of heterozygosity involving 9p21-22 in tumor tissue. (11807991)
2002
36
Primary malignant fibrous histiocytoma on the thyroid. (17018456)
2002
37
Intrascrotal malignant fibrous histiocytoma]. (10380332)
1999
38
Malignant fibrous histiocytoma of bone. A clinicopathologic study of 81 patients. (9028358)
1997
39
Immunophenotypic and immunoelectron microscopic characterization of major constituent cells in malignant fibrous histiocytoma using human cell lines and their transplanted tumors in immunodeficient mice. (7783426)
1995
40
Cytokines in inflammatory malignant fibrous histiocytoma presenting with leukemoid reaction. (7691245)
1993
41
Malignant fibrous histiocytomas in dogs and cats: an immunohistochemical study. (1332152)
1992
42
Pleural malignant fibrous histiocytoma concomitant with pulmonary adenocarcinoma. (1335205)
1992
43
Prognostic influence of HSP-27 expression in malignant fibrous histiocytoma: a clinicopathological and immunohistochemical study. (1313743)
1992
44
Malignant fibrous histiocytoma arising from discoid lupus erythematosus. (2827587)
1988
45
Postirradiation malignant fibrous histiocytoma arising in juvenile nasopharyngeal angiofibroma and producing alpha-1-antitrypsin. (6327493)
1984
46
Adjuvant chemotherapy of malignant fibrous histiocytoma of bone. (6295593)
1983
47
Primary malignant fibrous histiocytoma of bone: a case report. (6267151)
1981
48
Malignant fibrous histiocytoma of bone. (6262217)
1980
49
Malignant (fibrous) histiocytoma of bone--fact or fancy?. (192432)
1977
50
Neoplastic diseases of dogs; mast cell sarcoma, lymphosarcoma, histiocytoma. (18118928)
1948

Genetic Variations for Histiocytoma

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Expression for genes affiliated with Histiocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Histiocytoma

Search GEO for disease gene expression data for Histiocytoma.

Pathways for genes affiliated with Histiocytoma

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53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Histiocytoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.6S100B, FOXO4, MDM2, CREB1, ATF1, CD34
2
Hide members
10.6MDM2, CREB1, ATF1, DES, IL6R, VIM
3
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10.6FOXO4, MDM2, CREB1, ATF1, EREG
4
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10.6EREG, CREB1, MDM2, FOXO4, S100B
5
Hide members
10.5ACTC1, DES, VIM
6
Hide members
10.5EREG, CREB1, MDM2, FOXO4
7
Hide members
10.5FOXO4, MDM2, CREB1, EREG
810.5MYOD1, ATF1, CREB1
910.5MYOD1, CREB1, FOXO4
10
Hide members
10.5CREB1, ATF1
1110.5FOXO4, CREB1

Compounds for genes affiliated with Histiocytoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Histiocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.2ATF1, MDM2, S100A1, S100B, VIM, F13A1
2paraffin4411.2SERPINA3, VIM, S100B, S100A1, MDM2, F13A1
3calcium44 49 11 2414.1CREB1, MDM2, S100A1, S100B, HSPB2, ATF1
4vegf4411.1MDM2, S100B, HSPB2, VIM, CREB1, F13A1
5iron44 2412.1VIM, HSPB2, S100B, S100A1, MDM2, F13A1
6retinoic acid44 2412.1VIM, S100B, S100A1, CREB1, DES, MYOD1
7steroid4411.1MDM2, CREB1, ATF1, DES, MYOD1, IL6R
8tyrosine4411.1HSPB2, S100B, S100A1, MDM2, CREB1, DES
9oligonucleotide4411.1VIM, HSPB2, MDM2, CREB1, ATF1, F13A1
10hematoxylin4411.1VIM, S100B, S100A1, F13A1, DES, CD34
1112-o-tetradecanoylphorbol 13-acetate4411.1VIM, HSPB2, CREB1, ATF1, DES, MYOD1
12b 7234411.0VIM, S100B, S100A1, F13A1, DES, ACTC1
13testosterone44 59 11 2414.0VIM, S100B, MDM2, CREB1, DES, MYOD1
14s 1004411.0VIM, S100B, F13A1, DES, ACTC1
15arginine4411.0VIM, HSPB2, S100B, MDM2, DES, MYOD1
16mucicarmine4411.0VIM, S100B, S100A1, DES, ACTC1
17glycogen44 2412.0FOXO4, MDM2, CREB1, IL6R, ACTC1
18cyclic amp44 2412.0VIM, S100B, MDM2, CREB1, ATF1, DES
19reticulin4411.0VIM, DES, ACTC1
20cysteine4411.0VIM, S100B, S100A1, MDM2, CREB1, DES
21orcein4411.0VIM, S100B, DES, ACTC1
22acetylcholine44 49 28 11 2415.0HSPB2, S100A1, CREB1, MYOD1, SERPINA3
23creatinine4411.0HSPB2, MYOD1, IL6R, ACTC1, SERPINA3
24estradiol44 11 2413.0VIM, MDM2, CREB1, DES, IL6R, SERPINA3
25silver4411.0S100A1, F13A1, DES, CD34, SERPINA3
26wortmannin4411.0VIM, S100B, FOXO4, MDM2, CREB1, IL6R
27dexamethasone44 49 28 1114.0S100B, MDM2, CREB1, CD163, IL6R
28estrogen4411.0MYOD1, F13A1
29glutamine4410.9VIM, HSPB2, S100B, CREB1, F13A1, IL6R
30lysine4410.9VIM, HSPB2, MDM2, F13A1, DES, MYOD1
31serine4410.9HSPB2, S100B, ATF1, DES, MYOD1, SERPINA3
32zinc44 2411.9S100B, S100A1, MDM2, CREB1, MYOD1, IL6R
332-methoxyethanol4410.9VIM, S100A1, ACTC1
34leucine4410.9VIM, S100B, CREB1, ATF1, MYOD1, SERPINA3
35glucose4410.9SERPINA3, ACTC1, IL6R
36toluidine4410.9VIM, S100A1, DES
37lipid4410.9VIM, HSPB2, S100B, CREB1, CD163, CD68
38heparin44 28 11 2413.8S100B, F13A1, DES, SERPINA3
39oxygen44 2411.8HSPB2, S100B, MDM2, DES, MYOD1, ACTC1
40procollagen4410.8F13A1
41azathioprine44 49 2 1113.8VIM, CREB1, DES, MYOD1
42biotin44 11 2412.8VIM, S100A1, DES, ACTC1
43bromodeoxyuridine4410.7VIM, S100B, DES, MYOD1
44actomyosin4410.7ACTC1, S100A1, VIM
45actinomycin d4410.7MYOD1, DES, CREB1, MDM2, VIM
46formaldehyde44 2411.6VIM, S100B, DES, ACTC1
47imatinib44 49 1112.6ACTC1, DES, MDM2, S100B
48valine4410.6SERPINA3, MDM2, S100B, VIM
49forskolin44 49 1112.5VIM, S100B, CREB1, ATF1, EREG
50thapsigargin44 5911.3HSPB2, MDM2, CREB1, ATF1

GO Terms for genes affiliated with Histiocytoma

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16Gene Ontology
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Biological processes related to Histiocytoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1neurotrophin TRK receptor signaling pathwayGO:04801110.8EREG, ATF1, CREB1, MDM2, FOXO4
2phosphatidylinositol-mediated signalingGO:04801510.7FOXO4, MDM2, CREB1, EREG
3innate immune responseGO:04508710.7S100B, FOXO4, MDM2, CREB1, ATF1, EREG
4acute-phase responseGO:00695310.7SERPINA3, IL6R, CD163
5muscle filament slidingGO:03004910.6ACTC1, DES, VIM
6fibroblast growth factor receptor signaling pathwayGO:00854310.5FOXO4, MDM2, CREB1, EREG
7negative regulation of smooth muscle cell differentiationGO:05115110.5EREG, FOXO4
8Fc-epsilon receptor signaling pathwayGO:03809510.4FOXO4, MDM2, CREB1, EREG
9epidermal growth factor receptor signaling pathwayGO:00717310.2EREG, CREB1, MDM2, FOXO4

Molecular functions related to Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.6SERPINA3, VIM, HSPB2, S100B, S100A1, FOXO4
2S100 protein bindingGO:04454810.5S100A1, S100B
3identical protein bindingGO:04280210.3VIM, S100B, S100A1, MDM2, DES

Products for genes affiliated with Histiocytoma

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  • Antibodies
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Sources for Histiocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet