MCID: HST009
MIFTS: 54

Histiocytoma malady

Cancer diseases category

Summaries for Histiocytoma

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Wikipedia:64 A histiocytoma is a tumour consisting of histiocytes. Histiocytes are cells that are a part of the... more...

MalaCards based summary: Histiocytoma, also known as cutaneous fibrous histiocytoma, is related to fibrous histiocytoma and histiocytosis. An important gene associated with Histiocytoma is ATF1 (activating transcription factor 1), and among its related pathways are Aurora B signaling and Cytoskeletal Signaling. The compounds eosin and silver have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung, and related mouse phenotypes are muscle and normal.

Aliases & Classifications for Histiocytoma

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Histiocytoma, Aliases & Descriptions:

Name: Histiocytoma 9 11
 
Cutaneous Fibrous Histiocytoma 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:4231
NCIt39 C35765
MeSH34 D051642

Related Diseases for Histiocytoma

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Diseases related to Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 237)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma32.3CREB1, FUS
2histiocytosis31.2S100B
3cutaneous fibrous histiocytoma30.9DES, F13A1, ACTC1, S100B
4dedifferentiated liposarcoma30.7DES, MDM2
5meningioma30.6S100B, VIM
6myxoid liposarcoma30.6ATF1
7langerhans-cell histiocytosis30.6F13A1, S100B
8desmoid tumor30.5ACTC1, DES
9fasciitis30.5ACTC1
10rosai-dorfman disease30.4S100B
11liposarcoma30.4MDM2, VIM, FUS, DES
12rhabdoid tumor30.3DES, VIM, ACTC1
13chordoma30.3S100B, VIM, DES
14angiosarcoma30.3SERPINA3, VIM, ACTC1
15perineurioma30.3VIM, S100B
16dermatofibrosarcoma protuberans30.2DES, F13A1, VIM, ACTC1, S100B
17fibrosarcoma30.1MDM2, ACTC1, VIM, DES
18fibromatosis30.1ACTC1, VIM, DES
19spindle cell sarcoma30.1DES, VIM, ACTC1, S100B
20tuberous sclerosis30.0S100B, VIM, F13A1
21neurofibromatosis29.9S100B, CREB1
22leiomyosarcoma29.8DES, VIM, ACTC1, S100B, MDM2
23leiomyoma29.8S100B, ACTC1, VIM, DES
24sarcoma29.7DES, ATF1, FUS, F13A1, VIM, ACTC1
25hemangiopericytoma29.5MDM2, S100B, ACTC1, VIM, F13A1, DES
26giant cell tumor29.4ACTC1, VIM, SERPINA3, F13A1, DES, S100B
27rhabdomyosarcoma29.3DES, VIM, ACTC1, S100B, MDM2
28adenocarcinoma29.2F13A1, SERPINA3, VIM, ACTC1, CREB1, MDM2
29malignant fibroxanthoma29.2MDM2, S100B, IL6R, ACTC1, VIM, SERPINA3
30breast cancer29.1MDM2, IL6R, ACTC1, VIM, SERPINA3
31leukemia29.1ATF1, FUS, SERPINA3, IL6R, CREB1, MDM2
32melanoma28.6DES, ATF1, F13A1, SERPINA3, VIM, ACTC1
33malignant fibrous histiocytoma of bone10.8
34infantile myofibromatosis10.6DES
35pleomorphic malignant fibrous histiocytoma10.5
36diaphyseal medullary stenosis with malignant fibrous histiocytoma10.5
37syringoma10.5S100B
38adenomatoid tumor10.4VIM
39fibrous meningioma10.4S100B
40essential tremor10.4VIM
41osteosarcoma10.4
42aneurysm10.4
43hepatitis10.4
44mesenchymal chondrosarcoma10.4DES, VIM
45ganglioglioma10.4S100B
46alveolar soft part sarcoma10.4DES, VIM
47peripheral primitive neuroectodermal tumor10.3ATF1, FUS
48sertoli cell tumor10.3DES, VIM
49giant cell glioblastoma10.3MDM2
50adenosarcoma10.3DES, ACTC1

Graphical network of the top 20 diseases related to Histiocytoma:



Diseases related to histiocytoma

Symptoms for Histiocytoma

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Drugs & Therapeutics for Histiocytoma

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Drug clinical trials:

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Genetic Tests for Histiocytoma

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Anatomical Context for Histiocytoma

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MalaCards organs/tissues related to Histiocytoma:

32
Bone, Breast, Lung, Heart, Skin, Liver, Spleen, Colon, Pancreas, Kidney, Thyroid, Ovary, T cells, Cervix, Tongue, Trachea, Lymph node, Thymus, Brain, Smooth muscle, Adrenal gland, Prostate, Bone marrow, Skeletal muscle, Uterus, Testis, Testes, Monocytes, Endothelial

Animal Models for Histiocytoma or affiliated genes

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MGI Mouse Phenotypes related to Histiocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1MDM2, CREB1, ACTC1, VIM, DES
2MP:00028737.5ATF1, ACTC1, IL6R, CREB1, S100B, MDM2
3MP:00053857.5DES, F13A1, VIM, ACTC1, CREB1, MDM2
4MP:00053867.1DES, FUS, VIM, IL6R, CREB1, S100B
5MP:00053847.0ATF1, FUS, VIM, ACTC1, IL6R, CREB1
6MP:00107686.6MDM2, DES, ATF1, FUS, F13A1, VIM

Publications for Histiocytoma

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Articles related to Histiocytoma:

(show top 50)    (show all 801)
idTitleAuthorsYear
1
Epidermal inclusion cyst embedded in a recurrent benign fibrous histiocytoma. (25284857)
2014
2
Primary hepatic malignant fibrous histiocytoma mimicking hepatocellular carcinoma: A report of two cases. (25295102)
2014
3
Cytomorphometry of canine cutaneous histiocytoma. (25286647)
2014
4
Refractory Malignant Fibrous Histiocytoma: CT-guided Treatment with a Multidisciplinary, Minimally Invasive Approach. (24325132)
2013
5
An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report. (23347569)
2013
6
Primary malignant fibrous histiocytoma of the renal pelvis: a 78-month follow-up case report. (24368887)
2013
7
A therapeutic strategy for metastatic malignant fibrous histiocytoma through mesenchymal stromal cell-mediated TRAIL production. (23108118)
2013
8
Cholesterotic Fibrous Histiocytoma. (23518637)
2013
9
Malignant fibrous histiocytoma of the breast in young male patient: a case report and a review of the literature. (23573437)
2013
10
Malignant fibrous histiocytoma at the site of an alumina-on-alumina-bearing total hip arthroplasty mimicking infected trochanteric bursitis. (21435828)
2012
11
Clinical and pathologic characteristics and surgical management of benign fibrous histiocytoma of the mandible: a case report. (22580097)
2012
12
Benign fibrous histiocytoma of vulva: rare case. (24293888)
2012
13
A p53 gene mutation in malignant fibrous histiocytoma associated with bone infarction. (22041521)
2011
14
Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability. (21488163)
2011
15
Primary hepatic malignant fibrous histiocytoma: diagnostic pitfalls and therapeutic challenge. (21830410)
2011
16
Benign fibrous histiocytoma of bone in a paediatric population: a report of 6 cases. (21409501)
2011
17
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
18
Malignant fibrous histiocytoma of the small bowel with colon metastasis. (21590606)
2011
19
Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report. (20505510)
2010
20
An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy. (20492821)
2010
21
A rare clinical presentation of a malignant fibrous histiocytoma within the iliopsoas muscle. (20056053)
2010
22
Cardiac metastasis in malignant fibrous histiocytoma. (18626538)
2008
23
Prognostic significance of ezrin expression in pleomorphic malignant fibrous histiocytoma. (17465259)
2007
24
Squamous epithelial-lined cyst occurring in an aneurysmal fibrous histiocytoma. (17519635)
2007
25
Benign fibrous histiocytoma associated with a frontoethmoidal mucopyocele and orbital abscess. (17519668)
2007
26
Malignant fibrous histiocytoma of the parotid gland. (18188922)
2007
27
Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing. (16501844)
2006
28
Angiomatoid variant of fibrous histiocytoma: a case report and review of literature. (16879335)
2006
29
Diaphyseal medullary stenosis with pleomorphic malignant fibrous histiocytoma of the bone: 99mTc hydroxymethylenediphosphonate and 201Tl chloride scintigraphy findings. (16715956)
2006
30
Generalized eruptive histiocytoma: a pediatric case. (17229617)
2006
31
Aneurysmal fibrous histiocytoma of the skin: a rare variant of dermatofibroma. (16327640)
2005
32
Primary malignant fibrous histiocytoma of the pancreas: a case with K-ras mutation and a review of the literature. (16416164)
2005
33
Primary malignant fibrous histiocytoma of the jejunum metastatic to the spine: report of a case. (15879629)
2005
34
Malignant fibrous histiocytoma arising from the renal capsule. (16327309)
2005
35
Expression of matrix metalloproteinase-9 correlates with poor prognosis in human malignant fibrous histiocytoma. (20368833)
2004
36
Expression profiling using tissue microarray in 211 malignant fibrous histiocytomas confirms the prognostic value of Ki-67. (15309631)
2004
37
Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma. (12883752)
2003
38
Clinicopathologic features, diagnosis, and treatment of malignant fibrous histiocytoma of bone. (10642003)
2000
39
Cytogenetic, ras, and p53: studies in cases of canine neoplasms (hemangiopericytoma, mastocytoma, histiocytoma, chloroma). (9987918)
1999
40
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
41
Cutaneous fibrous histiocytoma with osteoclast-like giant cells. (8863988)
1996
42
P-53 positivity and high proliferative index: factors of bad prognosis in malignant fibrous histiocytomas. (8900926)
1995
43
Palisading cutaneous fibrous histiocytoma. An immunohistochemical study demonstrating differentiation from dermal dendrocytes. (8311187)
1993
44
Phenotypic characterization of the human fibrous histiocytoma giant cell tumor (GCT) cell line and its cytokine repertoire. (7689482)
1993
45
p53 immunohistochemistry in malignant fibrous histiocytomas and other mesenchymal tumours. (1333524)
1992
46
Malignant fibrous histiocytomas in dogs and cats: an immunohistochemical study. (1332152)
1992
47
Angioleiomyoma within a histiocytoma. (2258477)
1990
48
Chemotherapy-induced complete remission of a malignant fibrous histiocytoma of bone. An 11-year follow-up. (3008679)
1986
49
Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients. (3006524)
1986
50
Malignant fibrous histiocytoma of bone. (6262217)
1980

Variations for Histiocytoma

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Expression for genes affiliated with Histiocytoma

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Expression patterns in normal tissues for genes affiliated with Histiocytoma

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Pathways for genes affiliated with Histiocytoma

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Pathways related to Histiocytoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.9DES, VIM
29.5ACTC1, VIM, DES
3
Show member pathways
9.5ACTC1, VIM, DES
49.4ATF1, CREB1
59.4ATF1, CREB1
69.4ATF1, CREB1
79.1CREB1, IL6R
89.1FUS, MDM2, ATF1
9
Show member pathways
ATM Signaling Pathway37
9.0CREB1, MDM2
10
Show member pathways
Calcium Regulation in the Cardiac Cell37
9.0ATF1, CREB1, ACTC1
11
Show member pathways
9.0ATF1, CREB1, S100B
128.8CREB1, MDM2, ATF1
13
Show member pathways
8.6MDM2, CREB1, S100B
14
Show member pathways
7.6DES, ATF1, VIM, IL6R, CREB1, MDM2

Compounds for genes affiliated with Histiocytoma

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Compounds related to Histiocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1eosin449.7S100B, VIM
2silver449.7DES, SERPINA3, F13A1
3procollagen449.6ACTC1, VIM, F13A1, DES
4orcein449.5S100B, ACTC1, VIM, DES
5mucicarmine449.5VIM, ACTC1, DES, S100B
6formaldehyde44 2510.4S100B, ACTC1, VIM, DES
7methionine449.4S100B, DES, SERPINA3, VIM
8fibrinogen449.2IL6R, SERPINA3, F13A1, DES
9s 100449.2DES, VIM, ACTC1, F13A1, S100B
10reticulin449.2S100B, F13A1, DES, ACTC1, VIM
11b 723449.2DES, VIM, S100B, F13A1, ACTC1
12hematoxylin449.2F13A1, DES, S100B, ACTC1, VIM
13heparin44 29 25 1212.1VIM, SERPINA3, F13A1, DES, S100B
14imatinib44 50 1211.1MDM2, ACTC1, S100B, DES
15dbc-amp449.1VIM, S100B, CREB1
16valine449.1S100B, SERPINA3, VIM, MDM2
17methotrexate50 44 1210.9MDM2, IL6R, VIM, SERPINA3
18norepinephrine44 25 1210.9DES, S100B, ATF1, CREB1
19proline448.8DES, S100B, MDM2, VIM
20azathioprine44 3 50 1211.8VIM, DES, CREB1
21acetylcholine44 50 29 25 1212.7CREB1, DES, SERPINA3, VIM, S100B
22adenylate448.7DES, ATF1, VIM, CREB1, S100B
2312-o-tetradecanoylphorbol 13-acetate448.6VIM, ATF1, IL6R, DES, CREB1
24creatinine448.6IL6R, ACTC1, VIM, SERPINA3, DES, S100B
25glucose448.6S100B, SERPINA3, DES, ATF1, ACTC1, IL6R
26forskolin44 50 1210.6CREB1, S100B, VIM, ATF1
27etoposide44 50 60 1211.6CREB1, MDM2, S100B, VIM
28actinomycin d448.5MDM2, CREB1, VIM, DES
29glutamine448.5F13A1, VIM, IL6R, CREB1, S100B
30arginine448.3MDM2, S100B, VIM, SERPINA3, DES, IL6R
31paraffin448.3ACTC1, DES, SERPINA3, VIM, MDM2, S100B
32leucine448.2SERPINA3, S100B, CREB1, VIM, FUS, ATF1
33iron44 259.2F13A1, MDM2, S100B, ACTC1, VIM, SERPINA3
34threonine448.2MDM2, DES, SERPINA3, CREB1, S100B
35wortmannin448.1VIM, CREB1, S100B, IL6R, MDM2
36cyclic amp44 259.1VIM, S100B, CREB1, ATF1, DES, MDM2
37cysteine448.0VIM, MDM2, SERPINA3, S100B, CREB1, DES
38estradiol44 25 1210.0MDM2, VIM, SERPINA3, DES, IL6R, CREB1
39retinoic acid44 258.8SERPINA3, VIM, ACTC1, IL6R, CREB1, S100B
40serine447.7DES, SERPINA3, MDM2, VIM, CREB1, ATF1
41oligonucleotide447.7SERPINA3, CREB1, IL6R, VIM, MDM2, F13A1
42zinc44 258.7SERPINA3, CREB1, S100B, MDM2, IL6R, FUS
43glycogen44 258.6DES, VIM, MDM2, S100B, ACTC1, IL6R
44testosterone44 60 25 1210.5DES, MDM2, CREB1, IL6R, ACTC1, VIM
45progesterone44 29 60 25 1211.5IL6R, S100B, ACTC1, SERPINA3, F13A1, DES
46dexamethasone44 50 29 1210.5SERPINA3, MDM2, VIM, ACTC1, IL6R, CREB1
47estrogen447.4SERPINA3, VIM, F13A1, ACTC1, DES, MDM2
48steroid447.3IL6R, SERPINA3, DES, ACTC1, CREB1, S100B
49vegf447.3ACTC1, IL6R, CREB1, DES, F13A1, S100B
50calcium44 50 25 129.9MDM2, S100B, CREB1, IL6R, SERPINA3, ACTC1

GO Terms for genes affiliated with Histiocytoma

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Cellular components related to Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.5ACTC1, SERPINA3, F13A1

Biological processes related to Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.6ACTC1, VIM, DES
2acute-phase responseGO:0069539.5IL6R, SERPINA3
3response to drugGO:0424938.7CREB1, MDM2, ACTC1
4neurotrophin TRK receptor signaling pathwayGO:0480118.5MDM2, CREB1, ATF1
5innate immune responseGO:0450878.4CREB1, S100B, MDM2, ATF1

Molecular functions related to Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.5MDM2, VIM
2identical protein bindingGO:0428028.1DES, FUS, VIM, S100B, MDM2
3protein bindingGO:0055155.8MDM2, DES, ATF1, FUS, MFHAS1, SERPINA3

Products for genes affiliated with Histiocytoma

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Sources for Histiocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet