MCID: HST009
MIFTS: 56

Histiocytoma malady

Summaries for Histiocytoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A histiocytoma is a tumour consisting of histiocytes. Histiocytes are cells that are a part of the... more...

MalaCards: Histiocytoma, also known as cutaneous fibrous histiocytoma, is related to fibrous histiocytoma and cutaneous fibrous histiocytoma. An important gene associated with Histiocytoma is ATF1 (activating transcription factor 1), and among its related pathways are Immune System and Rho Family GTPases. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung, and related mouse phenotypes are normal and immune system.

Aliases & Classifications for Histiocytoma

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60UMLS, 8Disease Ontology, 10DISEASES, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

histiocytoma 8 10
cutaneous fibrous histiocytoma 60
histiocytoma, nos 8


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Disease Ontology8 DOID:4231
NCIt39 C35765
MeSH34 D051642

Related Diseases for Histiocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma31.8CD34, CREB1, FOXO4
2cutaneous fibrous histiocytoma30.9CD34, CD68, FOXO4
3sarcoma30.8ACTC1, CD34, CD163, MYOD1, DES, F13A1
4malignant fibroxanthoma30.6CD34, MFHAS1, FOXO4
5osteosarcoma30.5MDM2, CREB1, MYOD1, IL6R
6liposarcoma30.5CD34, DES, MDM2, VIM
7histiocytosis30.4S100B, CD163, CD68
8fibrosarcoma30.3VIM, MDM2, DES, CD34, ACTC1
9dermatofibrosarcoma30.3MDM2, FOXO4
10leiomyosarcoma30.2S100B, VIM, ACTC1, CD34, MYOD1, DES
11epithelioid sarcoma30.2VIM, CD34
12meningioma30.1VIM, S100B, S100A1, CD68, CD34
13fibrous meningioma30.1S100B
14hemangiopericytoma30.0ACTC1, CD34, DES, F13A1, MDM2, S100A1
15giant cell tumor30.0VIM, S100B, F13A1, DES, ACTC1, SERPINA3
16hemangioma30.0F13A1, CD163, CD68, CD34, ACTC1
17leukemia30.0MDM2, CREB1, ATF1, CD34, IL6R, SERPINA3
18langerhans-cell histiocytosis30.0S100B, S100A1, F13A1
19retinoblastoma30.0MYOD1, CREB1, MDM2
20squamous cell carcinoma30.0FOXO4
21myxoid liposarcoma30.0ATF1, MDM2
22melanoma29.9FOXO4, S100A1, S100B, HSPB2, VIM, MDM2
23adenocarcinoma29.9VIM, MDM2, CREB1, F13A1, CD34, ACTC1
24angiosarcoma29.9SERPINA3, ACTC1, CD34, VIM
25spindle cell sarcoma29.9ACTC1, DES, S100B, VIM
26hepatocellular carcinoma29.9IL6R, CD34, F13A1, ATF1, CREB1, MDM2
27chordoma29.9DES, S100A1, S100B, VIM
28neurofibromatosis29.9CREB1
29breast cancer29.7VIM, HSPB2, S100A1, MDM2, IL6R, ACTC1
30rhabdomyosarcoma29.7VIM, S100B, S100A1, MDM2, DES, MYOD1
31leiomyoma29.7VIM, S100B, S100A1, DES, CD34, ACTC1
32perineurioma29.7VIM, S100B, CD34
33acute leukemia29.7IL6R, CD34, CREB1, FOXO4
34colorectal cancer29.7MDM2, CD34, IL6R, EREG
35fasciitis29.7ACTC1
36tuberous sclerosis29.7F13A1, S100B, VIM
37pheochromocytoma29.7IL6R, CREB1
38non-hodgkin lymphoma29.7MDM2, MYOD1, CD34, IL6R
39pulmonary embolism29.7F13A1
40malignant fibrous histiocytoma of bone10.8
41diaphyseal medullary stenosis with malignant fibrous histiocytoma10.4
42bone osteosarcoma10.3
43hepatitis10.3
44hepatitis a10.2
45burn scar10.2
46burns10.2
47malignant skin fibrous histiocytoma10.2
48leukemoid reaction10.2
49benign deep fibrous histiocytoma10.2
50sclerosing hemangioma10.2

Graphical network of the top 20 diseases related to Histiocytoma:



Diseases related to histiocytoma

Clinical Features for Histiocytoma

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Drugs & Therapeutics for Histiocytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Histiocytoma

Drug clinical trials:

Search ClinicalTrials for Histiocytoma

Search NIH Clinical Center for Histiocytoma

Search CenterWatch for Histiocytoma

Genetic Tests for Histiocytoma

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Anatomical Context for Histiocytoma

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32MalaCards
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MalaCards organs/tissues related to Histiocytoma:

32
Bone, Breast, Lung, Heart, Skin, Liver, Spleen, Pancreas, Colon, Kidney, Ovary, Thyroid, T cells, Cervix, Tongue, Trachea, Adrenal gland, Lymph node, Smooth muscle, Prostate, Thymus, Brain, Endothelial, Monocytes, Testes, Testis, Uterus, Skeletal muscle, Bone marrow

Animal Models for Histiocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Histiocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.7EREG, S100B, S100A1, FOXO4, MDM2, CREB1
2MP:000538710.7HSPB2, MDM2, CREB1, ATF1, CD68, CD34
3MP:000536910.5HSPB2, MDM2, CREB1, MYOD1, ACTC1
4MP:000538510.4VIM, HSPB2, S100A1, MDM2, CREB1, F13A1

Publications for Histiocytoma

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50PubMed
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Articles related to Histiocytoma:

(show top 50)    (show all 784)
idTitleAuthorsYear
1
An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report. (23347569)
2013
2
Primary hepatic inflammatory malignant fibrous histiocytoma: report of a rare entity and diagnostic pitfall mimicking a liver abscess. (23635820)
2013
3
Regression of canine cutaneous histiocytoma: reduced proliferation or increased apoptosis? (23564778)
2013
4
Inflammatory malignant fibrous histiocytoma of the lung combined with fungal infection. (24238532)
2013
5
Malignant fibrous histiocytoma of right atrium. (23673127)
2013
6
Subcutaneous angiomatoid fibrous histiocytoma mimicking metastatic melanoma. (23320232)
2012
7
Malignant fibrous histiocytoma of the breast: a case report. (22953136)
2012
8
Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability. (21488163)
2011
9
Primary hepatic malignant fibrous histiocytoma: diagnostic pitfalls and therapeutic challenge. (21830410)
2011
10
Atypical fibrous histiocytoma with aberrant cytokeratin-5/6 expression. (21175722)
2011
11
Study of malignant fibrous histiocytoma: clinical, statistic and histopatological interrelation. (21424079)
2011
12
Soft tissue paraspinal inflammatory malignant fibrous histiocytoma presenting as a lumbar abscess. (21769293)
2011
13
Pleomorphic type of malignant fibrous histiocytoma with myxoid stroma of the vulva in a young woman. (21564409)
2011
14
Malignant fibrous histiocytoma of rectum: Report of a case. (22096699)
2011
15
Retroperitoneal malignant fibrous histiocytoma: case report. (20820088)
2010
16
Unusual localization of a malignant fibrous histiocytoma on the mitral valve. (19805411)
2010
17
Malignant fibrous histiocytoma of the distal femur after an arthroscopic anterior cruciate ligament reconstruction: A case report and a review of the literature. (20529315)
2010
18
Early radiation-induced laryngeal malignant fibrous histiocytoma (MFH). (19828415)
2009
19
Primary malignant fibrous histiocytoma of the thyroid: review of the literature with two new cases. (18302518)
2008
20
Peritoneal dissemination from malignant fibrous histiocytoma of the buttock: unusual metastases from a rare tumor. (20485650)
2008
21
Low-grade, aggressive fibrous histiocytoma of the medial canthus. (18347642)
2008
22
EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. (18094413)
2007
23
Cutaneous balloon cell dermatofibroma (fibrous histiocytoma). (17414448)
2007
24
iNOS-dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis. (17233833)
2007
25
A case of fibrous histiocytoma of the trachea in an infant treated by endobronchial ND:YAG laser. (17363105)
2007
26
Fibrous histiocytoma of the eyelid obliterating the punctum and the canaliculus. (18062498)
2007
27
Malignant fibrous histiocytoma arising from the aortic wall mimicking a pseudoaneurysm with ulceration. (17895569)
2007
28
Subcutaneous benign fibrous histiocytoma of the cheek. Case report and review of the literature. (17608138)
2007
29
Abdominal malignant fibrous histiocytoma infiltrating stomach with Chilaiditi's sign manifestation (a rare case report). (17684443)
2007
30
Completely wide resection of malignant fibrous histiocytoma of the chest wall; expect for long survival. (16702939)
2006
31
Benign fibrous histiocytoma of bone: a case report. (17183867)
2006
32
Malignant fibrous histiocytoma of the common hepatic duct: a case report. (17082693)
2006
33
Bilateral adrenal gland metastasis from malignant fibrous histiocytoma: value of [F-18]FDG PET-CT for diagnosis of occult metastases. (17385309)
2006
34
Malignant fibrous histiocytoma: pleomorphic sarcoma NOS or pleomorphic fibrosarcoma]. (15702318)
2005
35
Malignant fibrous histiocytoma of the heart complicated by factor XI deficiency in a Jehovah's Witness patient. (15620983)
2005
36
Doxorubicin and cisplatin chemotherapy in high-grade spindle cell sarcomas of the bone, other than osteosarcoma or malignant fibrous histiocytoma: a European Osteosarcoma Intergroup Study. (15661546)
2005
37
Pleomorphic malignant fibrous histiocytoma at the site of an arthroscopic reconstruction of the anterior cruciate ligament. A case report. (15687167)
2005
38
Malignant fibrous histiocytoma of the mesentery: report of two cases and review of the literature. (15847095)
2005
39
Mediastinal malignant fibrous histiocytoma developing from a foreign body granuloma. (16279594)
2005
40
Recurrent primary cardiac malignant fibrous histiocytoma following orthotopic heart transplantation. (15607678)
2004
41
Malignant fibrous histiocytoma associated with a meningothelial meningioma. (11846044)
2002
42
Beta-catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma. (12204056)
2002
43
Inflammatory malignant fibrous histiocytoma of the gallbladder: report of a case. (11871825)
2002
44
Clinicopathologic features, diagnosis, and treatment of malignant fibrous histiocytoma of bone. (10642003)
2000
45
Diaphyseal medullary stenosis with malignant fibrous histiocytoma: a hereditary bone dysplasia/cancer syndrome maps to 9p21-22. (10053015)
1999
46
Immunohistochemistry of dermatofibromas and benign fibrous histiocytomas. (7499573)
1995
47
Osteosarcoma versus malignant fibrous histiocytoma of bone in patients older than 40 years. A clinicopathologic and immunohistochemical analysis with special reference to malignant fibrous histiocytoma-like osteosarcoma. (8625223)
1995
48
Malignant fibrous histiocytoma of bone: the experience of the New South Wales Bone Tumour Registry. (8386925)
1993
49
Histopathologic diagnostic and histogenetic problems in malignant soft tissue tumors. Reassessment of malignant fibrous histiocytoma, epithelioid sarcoma, malignant rhabdoid tumor, and neuroectodermal tumor. (1466243)
1992
50
Primary chemotherapy and delayed surgery for malignant fibrous histiocytoma of bone in the extremity. (2178284)
1990

Genetic Variations for Histiocytoma

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Expression for genes affiliated with Histiocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Histiocytoma

Search GEO for disease gene expression data for Histiocytoma.

Pathways for genes affiliated with Histiocytoma

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53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Histiocytoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.6S100B, FOXO4, MDM2, CREB1, ATF1, CD34
2
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10.6MDM2, CREB1, ATF1, DES, IL6R, VIM
3
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10.6FOXO4, MDM2, CREB1, ATF1, EREG
4
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10.6EREG, CREB1, MDM2, FOXO4, S100B
5
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10.5ACTC1, DES, VIM
6
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10.5EREG, CREB1, MDM2, FOXO4
7
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10.5FOXO4, MDM2, CREB1, EREG
810.5MYOD1, ATF1, CREB1
910.5MYOD1, CREB1, FOXO4
10
Hide members
10.5CREB1, ATF1
1110.5FOXO4, CREB1

Compounds for genes affiliated with Histiocytoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Histiocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.2MDM2, S100A1, S100B, ATF1, F13A1, CD34
2paraffin4411.2CD163, DES, MYOD1, MDM2, S100B, CD34
3calcium44 49 11 2414.1ATF1, MYOD1, S100B, MDM2, CREB1, F13A1
4vegf4411.1HSPB2, S100B, MDM2, CREB1, DES, MYOD1
5iron44 2412.1F13A1, S100B, HSPB2, CD163, ACTC1, VIM
6retinoic acid44 2412.1CREB1, SERPINA3, ACTC1, IL6R, CD34, S100A1
7steroid4411.1MDM2, CREB1, SERPINA3, DES, MYOD1, IL6R
8tyrosine4411.1MYOD1, DES, CREB1, HSPB2, S100A1, S100B
9oligonucleotide4411.1VIM, HSPB2, MDM2, CREB1, ATF1, F13A1
10hematoxylin4411.1VIM, S100A1, ACTC1, F13A1, CD34, S100B
1112-o-tetradecanoylphorbol 13-acetate4411.1IL6R, HSPB2, CD34, DES, CREB1, VIM
12b 7234411.0S100A1, VIM, DES, ACTC1, S100B, F13A1
13testosterone44 59 11 2414.0CREB1, S100B, MDM2, VIM, ACTC1, IL6R
14s 1004411.0ACTC1, DES, F13A1, S100B, VIM
15arginine4411.0SERPINA3, S100B, IL6R, MDM2, VIM, HSPB2
16mucicarmine4411.0S100A1, S100B, DES, ACTC1, VIM
17glycogen44 2412.0CREB1, MDM2, ACTC1, IL6R, FOXO4
18cyclic amp44 2412.0DES, VIM, MDM2, S100B, CREB1, MYOD1
19reticulin4411.0VIM, ACTC1, DES
20cysteine4411.0MDM2, DES, CREB1, MYOD1, S100A1, S100B
21orcein4411.0VIM, S100B, ACTC1, DES
22acetylcholine44 49 28 11 2415.0MYOD1, CREB1, S100A1, HSPB2, SERPINA3
23creatinine4411.0SERPINA3, MYOD1, ACTC1, IL6R, HSPB2
24estradiol44 11 2413.0MDM2, SERPINA3, CREB1, DES, IL6R, VIM
25silver4411.0S100A1, F13A1, DES, CD34, SERPINA3
26wortmannin4411.0MDM2, IL6R, CREB1, FOXO4, S100B, VIM
27dexamethasone44 49 28 1114.0CD163, S100B, CREB1, IL6R, MDM2
28estrogen4411.0MYOD1, F13A1
29glutamine4410.9S100B, HSPB2, VIM, CREB1, F13A1, IL6R
30lysine4410.9VIM, DES, F13A1, MDM2, HSPB2, MYOD1
31serine4410.9HSPB2, S100B, ATF1, DES, MYOD1, SERPINA3
32zinc44 2411.9MDM2, CREB1, MYOD1, SERPINA3, IL6R, S100A1
332-methoxyethanol4410.9S100A1, ACTC1, VIM
34leucine4410.9CREB1, S100B, VIM, ATF1, MYOD1, SERPINA3
35glucose4410.9IL6R, ACTC1, SERPINA3
36toluidine4410.9DES, S100A1, VIM
37lipid4410.9CD163, VIM, SERPINA3, HSPB2, S100B, CREB1
38heparin44 28 11 2413.8S100B, F13A1, SERPINA3, DES
39oxygen44 2411.8SERPINA3, HSPB2, S100B, MDM2, DES, ACTC1
40procollagen4410.8F13A1
41azathioprine44 49 2 1113.8DES, VIM, CREB1, MYOD1
42biotin44 11 2412.8VIM, ACTC1, DES, S100A1
43bromodeoxyuridine4410.7MYOD1, DES, S100B, VIM
44actomyosin4410.7VIM, S100A1, ACTC1
45actinomycin d4410.7MDM2, DES, CREB1, VIM, MYOD1
46formaldehyde44 2411.6ACTC1, DES, S100B, VIM
47imatinib44 49 1112.6DES, ACTC1, MDM2, S100B
48valine4410.6VIM, S100B, MDM2, SERPINA3
49forskolin44 49 1112.5VIM, EREG, S100B, ATF1, CREB1
50thapsigargin44 5911.3MDM2, HSPB2, CREB1, ATF1

GO Terms for genes affiliated with Histiocytoma

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16Gene Ontology
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Biological processes related to Histiocytoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1neurotrophin TRK receptor signaling pathwayGO:04801110.8EREG, ATF1, CREB1, MDM2, FOXO4
2phosphatidylinositol-mediated signalingGO:04801510.7FOXO4, MDM2, CREB1, EREG
3innate immune responseGO:04508710.7S100B, FOXO4, MDM2, CREB1, ATF1, EREG
4acute-phase responseGO:00695310.7SERPINA3, IL6R, CD163
5muscle filament slidingGO:03004910.6ACTC1, DES, VIM
6fibroblast growth factor receptor signaling pathwayGO:00854310.5FOXO4, MDM2, CREB1, EREG
7negative regulation of smooth muscle cell differentiationGO:05115110.5EREG, FOXO4
8Fc-epsilon receptor signaling pathwayGO:03809510.4FOXO4, MDM2, CREB1, EREG
9epidermal growth factor receptor signaling pathwayGO:00717310.2EREG, CREB1, MDM2, FOXO4

Molecular functions related to Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.6SERPINA3, VIM, HSPB2, S100B, S100A1, FOXO4
2S100 protein bindingGO:04454810.5S100A1, S100B
3identical protein bindingGO:04280210.3VIM, S100B, S100A1, MDM2, DES

Products for genes affiliated with Histiocytoma

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  • Antibodies
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Sources for Histiocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet