MCID: HST009
MIFTS: 55

Histiocytoma malady

Cancer diseases category

Summaries for Histiocytoma

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 A histiocytoma is a tumour consisting of histiocytes. Histiocytes are cells that are a part of the... more...

MalaCards: Histiocytoma, also known as cutaneous fibrous histiocytoma, is related to fibrous histiocytoma and cutaneous fibrous histiocytoma. An important gene associated with Histiocytoma is ATF1 (activating transcription factor 1), and among its related pathways are Aurora B signaling and Cytoskeletal Signaling. The compounds eosin and silver have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung, and related mouse phenotypes are muscle and normal.

Aliases & Classifications for Histiocytoma

About this section
Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

histiocytoma 9 11
cutaneous fibrous histiocytoma 63
histiocytoma, nos 9


External Ids:

Disease Ontology9 DOID:4231
NCIt41 C35765
MeSH36 D051642

Related Diseases for Histiocytoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma32.0CREB1, FUS
2cutaneous fibrous histiocytoma30.8DES, F13A1, ACTC1, S100B
3sarcoma30.6DES, ATF1, FUS, F13A1, VIM, ACTC1
4histiocytosis30.5F13A1, S100B
5liposarcoma30.5MDM2, VIM, FUS, DES
6dermatofibrosarcoma30.5MDM2
7dedifferentiated liposarcoma30.4DES, MDM2
8dermatofibrosarcoma protuberans30.3DES, F13A1, VIM, ACTC1, S100B
9meningioma30.3S100B, VIM
10fibrosarcoma30.3MDM2, ACTC1, VIM, DES
11langerhans-cell histiocytosis30.2F13A1, S100B
12leiomyosarcoma30.2DES, VIM, ACTC1, S100B, MDM2
13malignant fibroxanthoma30.2MDM2, S100B, IL6R, ACTC1, VIM, SERPINA3
14desmoid tumor30.1ACTC1, DES
15rhabdoid tumor30.1DES, VIM, ACTC1
16chordoma30.1S100B, VIM, DES
17angiosarcoma30.0SERPINA3, VIM, ACTC1
18spindle cell sarcoma30.0DES, VIM, ACTC1, S100B
19myxoid liposarcoma30.0ATF1
20hemangiopericytoma30.0MDM2, S100B, ACTC1, VIM, F13A1, DES
21neurofibromatosis30.0S100B, CREB1
22fasciitis29.9ACTC1
23rosai-dorfman disease29.9S100B
24perineurioma29.9VIM, S100B
25leukemia29.9ATF1, FUS, SERPINA3, IL6R, CREB1, MDM2
26fibromatosis29.8ACTC1, VIM, DES
27tuberous sclerosis29.8S100B, VIM, F13A1
28hepatocellular carcinoma29.8ATF1, F13A1, IL6R, CREB1, MDM2
29adenocarcinoma29.8F13A1, SERPINA3, VIM, ACTC1, CREB1, MDM2
30leiomyoma29.8S100B, ACTC1, VIM, DES
31giant cell tumor29.7ACTC1, VIM, SERPINA3, F13A1, DES, S100B
32rhabdomyosarcoma29.6DES, VIM, ACTC1, S100B, MDM2
33melanoma29.6DES, ATF1, F13A1, SERPINA3, VIM, ACTC1
34breast cancer29.6MDM2, IL6R, ACTC1, VIM, SERPINA3
35malignant fibrous histiocytoma of bone10.8
36diaphyseal medullary stenosis with malignant fibrous histiocytoma10.5
37pleomorphic malignant fibrous histiocytoma10.5
38osteosarcoma10.4
39aneurysm10.4
40hepatitis10.4
41burn scar10.2
42burns10.2
43leukemoid reaction10.2
44epithelioid sarcoma10.2
45sclerosing hemangioma10.2
46thyroiditis10.2
47soft tissue sarcoma10.2
48generalized eruptive histiocytosis10.2
49malignant skin fibrous histiocytoma10.1
50infantile myofibromatosis10.1DES

Graphical network of the top 20 diseases related to Histiocytoma:



Diseases related to histiocytoma

Symptoms for Histiocytoma

About this section

Drugs & Therapeutics for Histiocytoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Histiocytoma

Drug clinical trials:

Search ClinicalTrials for Histiocytoma

Search NIH Clinical Center for Histiocytoma

Search CenterWatch for Histiocytoma

Genetic Tests for Histiocytoma

About this section

Anatomical Context for Histiocytoma

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Histiocytoma:

34
Bone, Breast, Lung, Heart, Skin, Liver, Spleen, Pancreas, Colon, Kidney, Ovary, Thyroid, T cells, Cervix, Tongue, Trachea, Adrenal gland, Lymph node, Smooth muscle, Prostate, Thymus, Brain, Endothelial, Monocytes, Testes, Testis, Uterus, Skeletal muscle, Bone marrow

Animal Models for Histiocytoma or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Histiocytoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1MDM2, CREB1, ACTC1, VIM, DES
2MP:00028737.5ATF1, ACTC1, IL6R, CREB1, S100B, MDM2
3MP:00053857.5DES, F13A1, VIM, ACTC1, CREB1, MDM2
4MP:00053867.1DES, FUS, VIM, IL6R, CREB1, S100B
5MP:00053847.0ATF1, FUS, VIM, ACTC1, IL6R, CREB1
6MP:00107686.6MDM2, DES, ATF1, FUS, F13A1, VIM

Publications for Histiocytoma

About this section
Sources:
53PubMed
See all sources

Articles related to Histiocytoma:

(show top 50)    (show all 777)
idTitleAuthorsYear
1
Refractory Malignant Fibrous Histiocytoma: CT-guided Treatment with a Multidisciplinary, Minimally Invasive Approach. (24325132)
2013
2
An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report. (23347569)
2013
3
Primary malignant fibrous histiocytoma of the renal pelvis: a 78-month follow-up case report. (24368887)
2013
4
A therapeutic strategy for metastatic malignant fibrous histiocytoma through mesenchymal stromal cell-mediated TRAIL production. (23108118)
2013
5
Cholesterotic Fibrous Histiocytoma. (23518637)
2013
6
Malignant fibrous histiocytoma of the breast in young male patient: a case report and a review of the literature. (23573437)
2013
7
Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma. (23800015)
2013
8
Malignant fibrous histiocytoma at the site of an alumina-on-alumina-bearing total hip arthroplasty mimicking infected trochanteric bursitis. (21435828)
2012
9
Clinical and pathologic characteristics and surgical management of benign fibrous histiocytoma of the mandible: a case report. (22580097)
2012
10
Benign fibrous histiocytoma of vulva: rare case. (24293888)
2012
11
A p53 gene mutation in malignant fibrous histiocytoma associated with bone infarction. (22041521)
2011
12
Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability. (21488163)
2011
13
Primary hepatic malignant fibrous histiocytoma: diagnostic pitfalls and therapeutic challenge. (21830410)
2011
14
Benign fibrous histiocytoma of bone in a paediatric population: a report of 6 cases. (21409501)
2011
15
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
16
Malignant fibrous histiocytoma of the small bowel with colon metastasis. (21590606)
2011
17
Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report. (20505510)
2010
18
An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy. (20492821)
2010
19
A rare clinical presentation of a malignant fibrous histiocytoma within the iliopsoas muscle. (20056053)
2010
20
Cardiac metastasis in malignant fibrous histiocytoma. (18626538)
2008
21
Prognostic significance of ezrin expression in pleomorphic malignant fibrous histiocytoma. (17465259)
2007
22
Squamous epithelial-lined cyst occurring in an aneurysmal fibrous histiocytoma. (17519635)
2007
23
Benign fibrous histiocytoma associated with a frontoethmoidal mucopyocele and orbital abscess. (17519668)
2007
24
Malignant fibrous histiocytoma of the parotid gland. (18188922)
2007
25
Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing. (16501844)
2006
26
Angiomatoid variant of fibrous histiocytoma: a case report and review of literature. (16879335)
2006
27
Diaphyseal medullary stenosis with pleomorphic malignant fibrous histiocytoma of the bone: 99mTc hydroxymethylenediphosphonate and 201Tl chloride scintigraphy findings. (16715956)
2006
28
Generalized eruptive histiocytoma: a pediatric case. (17229617)
2006
29
Aneurysmal fibrous histiocytoma of the skin: a rare variant of dermatofibroma. (16327640)
2005
30
Primary malignant fibrous histiocytoma of the pancreas: a case with K-ras mutation and a review of the literature. (16416164)
2005
31
Primary malignant fibrous histiocytoma of the jejunum metastatic to the spine: report of a case. (15879629)
2005
32
Malignant fibrous histiocytoma arising from the renal capsule. (16327309)
2005
33
Malignant fibrous histiocytoma, malignant melanoma and squamous cell carcinoma arising from different areas in an adult. (16440931)
2005
34
Expression of matrix metalloproteinase-9 correlates with poor prognosis in human malignant fibrous histiocytoma. (20368833)
2004
35
Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma. (12883752)
2003
36
Clinicopathologic features, diagnosis, and treatment of malignant fibrous histiocytoma of bone. (10642003)
2000
37
Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11. (11063792)
2000
38
Cytogenetic, ras, and p53: studies in cases of canine neoplasms (hemangiopericytoma, mastocytoma, histiocytoma, chloroma). (9987918)
1999
39
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
40
Cutaneous fibrous histiocytoma with osteoclast-like giant cells. (8863988)
1996
41
P-53 positivity and high proliferative index: factors of bad prognosis in malignant fibrous histiocytomas. (8900926)
1995
42
Palisading cutaneous fibrous histiocytoma. An immunohistochemical study demonstrating differentiation from dermal dendrocytes. (8311187)
1993
43
Phenotypic characterization of the human fibrous histiocytoma giant cell tumor (GCT) cell line and its cytokine repertoire. (7689482)
1993
44
p53 immunohistochemistry in malignant fibrous histiocytomas and other mesenchymal tumours. (1333524)
1992
45
Malignant fibrous histiocytomas in dogs and cats: an immunohistochemical study. (1332152)
1992
46
Angioleiomyoma within a histiocytoma. (2258477)
1990
47
Chemotherapy-induced complete remission of a malignant fibrous histiocytoma of bone. An 11-year follow-up. (3008679)
1986
48
Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients. (3006524)
1986
49
A study on the osseous elements in malignant fibrous histiocytoma of bone. (2989393)
1985
50
Malignant fibrous histiocytoma of bone. (6262217)
1980

Variations for Histiocytoma

About this section

Expression for genes affiliated with Histiocytoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Histiocytoma

Search GEO for disease gene expression data for Histiocytoma.

Pathways for genes affiliated with Histiocytoma

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 5Cell Signaling Technology, 56Reactome, 61Thomson Reuters, 31KEGG, 54QIAGEN
See all sources

Pathways related to Histiocytoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases39
Aurora C signaling39
9.9DES, VIM
29.5DES, VIM, ACTC1
3
Show member pathways
9.5ACTC1, VIM, DES
49.4ATF1, CREB1
59.4CREB1, ATF1
69.4CREB1, ATF1
79.1CREB1, IL6R
89.1ATF1, FUS, MDM2
9
Show member pathways
ATM Signaling Pathway39
9.0MDM2, CREB1
10
Show member pathways
Calcium Regulation in the Cardiac Cell39
9.0CREB1, ACTC1, ATF1
11
Show member pathways
9.0ATF1, CREB1, S100B
128.8MDM2, CREB1, ATF1
13
Show member pathways
8.6MDM2, S100B, CREB1
14
Show member pathways
7.6MDM2, DES, ATF1, VIM, IL6R, CREB1

Compounds for genes affiliated with Histiocytoma

About this section
Sources:
46Novoseek, 25HMDB, 30IUPHAR, 12DrugBank, 52PharmGKB, 3BitterDB, 62Tocris Bioscience
See all sources

Compounds related to Histiocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1eosin469.7S100B, VIM
2silver469.7DES, F13A1, SERPINA3
3procollagen469.6DES, F13A1, VIM, ACTC1
4orcein469.5DES, VIM, ACTC1, S100B
5mucicarmine469.5DES, VIM, ACTC1, S100B
6formaldehyde46 2510.4DES, VIM, ACTC1, S100B
7methionine469.4S100B, VIM, SERPINA3, DES
8fibrinogen469.2DES, F13A1, SERPINA3, IL6R
9s 100469.2S100B, ACTC1, VIM, F13A1, DES
10reticulin469.2DES, F13A1, VIM, ACTC1, S100B
11b 723469.2S100B, ACTC1, VIM, F13A1, DES
12hematoxylin469.2DES, F13A1, VIM, ACTC1, S100B
13heparin46 30 25 1212.1DES, F13A1, SERPINA3, VIM, S100B
14imatinib46 52 1211.1MDM2, S100B, ACTC1, DES
15dbc-amp469.1S100B, CREB1, VIM
16valine469.1MDM2, S100B, VIM, SERPINA3
17methotrexate52 46 1210.9MDM2, IL6R, VIM, SERPINA3
18norepinephrine46 25 1210.9S100B, CREB1, ATF1, DES
19proline468.8MDM2, S100B, VIM, DES
20azathioprine46 3 52 1211.8CREB1, VIM, DES
21acetylcholine46 52 30 25 1212.7DES, SERPINA3, VIM, CREB1, S100B
22adenylate468.7DES, ATF1, VIM, CREB1, S100B
2312-o-tetradecanoylphorbol 13-acetate468.6CREB1, IL6R, VIM, ATF1, DES
24creatinine468.6DES, SERPINA3, VIM, ACTC1, IL6R, S100B
25glucose468.6DES, ATF1, SERPINA3, ACTC1, IL6R, S100B
26etoposide46 52 62 1211.6VIM, CREB1, S100B, MDM2
27forskolin46 52 1210.6ATF1, VIM, CREB1, S100B
28actinomycin d468.5DES, VIM, CREB1, MDM2
29glutamine468.5F13A1, VIM, IL6R, CREB1, S100B
30arginine468.3DES, SERPINA3, VIM, IL6R, S100B, MDM2
31paraffin468.3DES, F13A1, SERPINA3, VIM, ACTC1, S100B
32leucine468.2ATF1, FUS, SERPINA3, VIM, CREB1, S100B
33iron46 259.2DES, F13A1, SERPINA3, VIM, ACTC1, S100B
34threonine468.2DES, SERPINA3, CREB1, S100B, MDM2
35wortmannin468.1VIM, IL6R, CREB1, S100B, MDM2
36cyclic amp46 259.1DES, ATF1, VIM, CREB1, S100B, MDM2
37cysteine468.0DES, SERPINA3, VIM, CREB1, S100B, MDM2
38estradiol46 25 1210.0DES, SERPINA3, VIM, IL6R, CREB1, MDM2
39retinoic acid46 258.8DES, SERPINA3, VIM, ACTC1, IL6R, CREB1
40serine467.7DES, ATF1, SERPINA3, VIM, CREB1, S100B
41oligonucleotide467.7ATF1, F13A1, SERPINA3, VIM, IL6R, CREB1
42zinc46 258.7FUS, SERPINA3, IL6R, CREB1, S100B, MDM2
43glycogen46 258.6DES, VIM, ACTC1, IL6R, CREB1, S100B
44testosterone46 62 25 1210.5DES, VIM, ACTC1, IL6R, CREB1, S100B
45progesterone46 30 62 25 1211.5DES, ATF1, F13A1, SERPINA3, VIM, ACTC1
46dexamethasone46 52 30 1210.5SERPINA3, VIM, ACTC1, IL6R, CREB1, S100B
47estrogen467.4DES, F13A1, SERPINA3, VIM, ACTC1, CREB1
48steroid467.3DES, ATF1, SERPINA3, ACTC1, IL6R, CREB1
49vegf467.3DES, F13A1, VIM, ACTC1, IL6R, CREB1
50calcium46 52 25 129.9DES, ATF1, F13A1, SERPINA3, ACTC1, IL6R

GO Terms for genes affiliated with Histiocytoma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.5ACTC1, SERPINA3, F13A1

Biological processes related to Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.6ACTC1, VIM, DES
2acute-phase responseGO:0069539.5SERPINA3, IL6R
3response to drugGO:0424938.7MDM2, CREB1, ACTC1
4neurotrophin TRK receptor signaling pathwayGO:0480118.5MDM2, CREB1, ATF1
5innate immune responseGO:0450878.4MDM2, S100B, CREB1, ATF1

Molecular functions related to Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.5MDM2, VIM
2identical protein bindingGO:0428028.1DES, FUS, VIM, S100B, MDM2
3protein bindingGO:0055155.8MDM2, DES, ATF1, FUS, MFHAS1, SERPINA3

Products for genes affiliated with Histiocytoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Histiocytoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet