MCID: HST010
MIFTS: 62

Histiocytosis malady

Rare diseases, Immune diseases categories

Summaries for Histiocytosis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 In medicine, histiocytosis refers to an excessive number of histiocytes, (tissue macrophages), and is... more...

MalaCards: Histiocytosis, also known as hand-schuller-christian syndrome, is related to langerhans-cell histiocytosis and malignant histiocytosis. An important gene associated with Histiocytosis is F13A1 (coagulation factor XIII, A1 polypeptide), and among its related pathways are Signaling events mediated by PTP1B and Integrins in angiogenesis. The drugs etoposide and vinblastine and the compounds mdms and aclarubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotypes are integument and cardiovascular system.

Disease Ontology:9 A lymphatic system disease that is characterized by an excessive number of histiocytes.

Aliases & Classifications for Histiocytosis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


Aliases & Descriptions:

histiocytosis 9 11 46 63
hand-schuller-christian syndrome 44
hand schuller christian disease 9
hand-schuller-christian disease 44
histiocytosis, langerhans-cell 63
chronic histiocytosis x 9


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Disease Ontology9 DOID:3405
MeSH36 D015614
NCIt41 C3106

Related Diseases for Histiocytosis

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18GeneCards, 19GeneDecks
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Diseases in the Histiocytosis family:

Malignant Histiocytosis

Diseases related to Histiocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 327)
idRelated DiseaseScoreTop Affiliating Genes
1langerhans-cell histiocytosis32.0F13A1, S100B
2malignant histiocytosis31.6CSF1, CSF1R, MYB
3rosai-dorfman disease31.2S100B
4juvenile xanthogranuloma30.8F13A1, S100B
5leukemia30.7MYB, LIF, CSF1R, CSF1, CD1A
6sarcoma30.3F13A1, ACTC1, CSF1R, CSF1, S100B, CD1A
7langerhans cell sarcoma30.2CD207
8monocytic leukemia30.2CSF1, LIF
9arthritis30.2LIF, CSF1R, CSF1
10rheumatoid arthritis30.2F13A1, MYB, LIF, CSF1
11chronic myelomonocytic leukemia30.1CSF1R, CSF1
12fibrous histiocytoma30.1F13A1, ACTC1, S100B
13acute leukemia30.0CSF1, CSF1R, MYB
14myeloid leukemia30.0CSF1, CSF1R, LIF, MYB
15teratoma29.9ACTC1, LIF
16acute myelomonocytic leukemia29.8CSF1R, CSF1
17adenocarcinoma29.7CSF1R, ACTC1, LIF, MYB, F13A1
18papilloma29.7ACTC1
19osteoarthritis29.7F13A1, LIF, CSF1R, CSF1
20glioblastoma multiforme29.6S100B, CSF1R, MYB
21sea-blue histiocytosis10.6
22benign cephalic histiocytosis10.6
23non-langerhans-cell histiocytosis10.6
24indeterminate cell histiocytosis10.5
25erdheim-chester disease10.5
26diabetes insipidus10.5
27thyroiditis10.4
28progressive nodular histiocytosis10.4
29generalized eruptive histiocytosis10.4
30hereditary progressive mucinous histiocytosis10.3
31histiocytosis-lymphadenopathy plus syndrome10.3
32niemann-pick disease10.3
33b-cell lymphomas10.3
34adult pulmonary langerhans cell histiocytosis10.3
35mediastinitis10.3
36virus associated hemophagocytic syndrome10.3
37histiocytoma10.3
38pneumothorax10.3
39gaucher's disease10.2
40cervicitis10.2
41histiocytic sarcoma10.2
42hodgkin's lymphoma10.2
43alk+ histiocytosis10.2
44germ cell tumors10.2
45central nervous system disease10.2
46myeloma10.2
47nervous system disease10.2
48pneumonia10.2
49scabies10.2
50histiocytosis with joint contractures and sensorineural deafness10.2

Graphical network of the top 20 diseases related to Histiocytosis:



Diseases related to histiocytosis

Symptoms for Histiocytosis

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Drugs & Therapeutics for Histiocytosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Histiocytosis

Drug clinical trials:

Search ClinicalTrials for Histiocytosis

Search NIH Clinical Center for Histiocytosis

Search CenterWatch for Histiocytosis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Histiocytosis

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Anatomical Context for Histiocytosis

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34MalaCards
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MalaCards organs/tissues related to Histiocytosis:

34
Bone, Bone marrow, T cells, Skin, Thyroid, Lung, Liver, B cells, Myeloid, Monocytes, Pituitary, Lymph node, Spleen, Colon, Brain, Pancreas, Breast, Testes, Spinal cord, Tongue, Small intestine, Thymus, Heart, Eye, Temporal lobe, Tonsil

Animal Models for Histiocytosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Histiocytosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.8MYB, LIF, CSF1R, CSF1, S100B
2MP:00053857.8CSF1, ACTC1, LIF, MYB, F13A1
3MP:00053877.7MYB, LIF, CSF1R, CSF1, CD207, SLC29A3
4MP:00053977.5SLC29A3, F13A1, MYB, LIF, CSF1R, CSF1
5MP:00107686.9F13A1, MYB, LIF, ACTC1, CSF1R, CSF1
6MP:00053846.9MYB, LIF, ACTC1, CSF1R, CSF1, SLC29A3

Publications for Histiocytosis

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53PubMed
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Articles related to Histiocytosis:

(show top 50)    (show all 1320)
idTitleAuthorsYear
1
Skeletal involvement in Langerhans cell histiocytosis. (23907805)
2013
2
Rapid resolution of pulmonary Langerhans cell histiocytosis. (23749831)
2013
3
Multisystem Langerhans cell histiocytosis in adult. (22470214)
2012
4
Rosai-dorfman disease (sinus histiocytosis with massive lymphadenopathy) of the pancreas: third reported occurrence. (22864941)
2012
5
Juvenile xanthogranuloma developing after treatment of Langerhans cell histiocytosis: case report and literature review. (22977671)
2012
6
Langerhans' cell histiocytosis of the temporal bone. (21725272)
2012
7
Concomitant occurrence of sinus histiocytosis with massive lymphadenopathy and nodal marginal zone lymphoma. (21366466)
2011
8
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. (21769315)
2011
9
Treatment of patients with hypothalamic-pituitary lesions as adult-onset Langerhans cell histiocytosis. (22015494)
2011
10
Case report: Langerhans cell histiocytosis presenting as massive cervical adenopathy and retropharyngeal thickening: importance of chest radiography and coordinated airway and anesthetic management. (20145506)
2010
11
Uncommon features of pulmonary Langerhans' cell histiocytosis: analysis of 11 cases and a review of the literature. (20193493)
2010
12
Cutaneous Langerhans cell histiocytosis in an elderly woman. (21062600)
2010
13
A role for ITPA variants in the clinical course of pulmonary Langerhans' cell histiocytosis? (20930204)
2010
14
Langerhans cell histiocytosis with thyroid and lung involvement in a child: a case report. (20224443)
2010
15
A case of a Korean adult affected by type B Niemann-Pick disease: secondary sea-blue histiocytosis and molecular characterization]. (19411774)
2009
16
Japanese case of benign cephalic histiocytosis. (19207442)
2009
17
Cranial unifocal Langerhans cell histiocytosis in children. (19302861)
2009
18
Cerebral non-Langerhans cell histiocytosis in a 17-year-old patient with a headache: case report. (19363626)
2009
19
Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) of the pancreas: second case report. (19020944)
2009
20
A case of langerhans cell histiocytosis with anal fistula. (20505285)
2009
21
Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1. (17874453)
2008
22
Progressive nodular histiocytosis - A five-year follow up. (18424392)
2008
23
Sinus histiocytosis with massive lymphadenopathy (Rosai Dorfman disease): evidence for a dendritic cell derivation? (16761737)
2005
24
Indeterminate cell histiocytosis: a case report. (15481563)
2004
25
Primary histiocytic sarcoma of the spleen associated with erythrophagocytic histiocytosis. (12747473)
2003
26
Serum levels of interleukin-1 receptor antagonist and tumor necrosis factor-alpha are elevated in children with Langerhans cell histiocytosis. (12794527)
2003
27
Extranodal sinus histiocytosis (Rosai-Dorfman disease) of the brain parenchyma. (12601463)
2003
28
Sinus histiocytosis with massive lymphadenopathy: complicated by autoimmune hemolytic anemia. (14620195)
2003
29
Extranodal marginal zone B-cell lymphoma of the lacrimal gland associated with crystal-storing histiocytosis. (11772588)
2002
30
Benign cephalic histiocytosis progressing into juvenile xanthogranuloma: a non-Langerhans cell histiocytosis transforming under the influence of a virus? (10698221)
2000
31
Detection of Langerhans cell histiocytosis lesions with somatostatin analogue scintigraphy--a preliminary report. (11070478)
2000
32
Indeterminate-cell histiocytosis: immunophenotypic and cytogenetic findings in an infant. (10102017)
1999
33
DNA polymorphisms and mutations of the tumor necrosis factor-alpha (TNF-alpha) promoter in Langerhans cell histiocytosis (LCH). (9355965)
1997
34
Modulation of fibroblast activity in histiocytosis X by platelet-derived growth factor. (7874940)
1995
35
Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35. (1313990)
1992
36
Benign cephalic histiocytosis: a case report. (2400727)
1990
37
Malignant histiocytosis presenting as erythroderma. (2139870)
1990
38
Distribution of three proteinases in tumor cells of malignant histiocytosis]. (2279308)
1990
39
An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis. (2670186)
1989
40
Chronic myelomonocytic leukemia terminating as malignant histiocytosis. (3334348)
1987
41
Malignant histiocytosis complicating rheumatoid arthritis: report of four cases. (3950028)
1986
42
Chromosomal and fluorometric DNA analyses of malignant histiocytosis. (3811786)
1986
43
Histiocytosis X and erythropoietic protoporphyria. (6607997)
1984
44
Erythema annulare centrifugum and malignant histiocytosis--report of a case. (6499278)
1984
45
Malignant histiocytosis. Clinical and cytogenetic studies in a newborn and a child. (6883287)
1983
46
Non-B, non-T acute lymphoblastic leukaemia terminating in malignant histiocytosis: a new case and a review of the literature. (6293942)
1982
47
Ichthyosis and marrow involvement in malignant histiocytosis of the intestine. (7236527)
1981
48
Malignant histiocytosis in childhood: clinical study and therapeutic results in 22 cases. (7379013)
1980
49
Malignant histiocytosis in children from the Eastern Mediterranean. (7453672)
1980
50
Malignant histiocytosis associated with malabsorption. (262066)
1979

Variations for Histiocytosis

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Expression for genes affiliated with Histiocytosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Histiocytosis

Search GEO for disease gene expression data for Histiocytosis.

Pathways for genes affiliated with Histiocytosis

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51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG
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Compounds for genes affiliated with Histiocytosis

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46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Histiocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1mdms469.8S100B, CSF1
2aclarubicin469.7CSF1, MYB
3filgrastim46 1210.7CSF1, LIF
4orcein469.6S100B, ACTC1
5mucicarmine469.5S100B, ACTC1
6ecori469.4MYB, S100B
7gm-csf46 3010.4CSF1, CSF1R, LIF
8bryostatin 1469.4CSF1, CSF1R
9adenine46 25 1211.4SLC29A3, S100B, MYB
10s 100469.4S100B, ACTC1, F13A1
11reticulin469.4S100B, ACTC1, F13A1
12b 723469.4F13A1, ACTC1, S100B
13sodium nitroprusside469.4S100B, CSF1, MYB
14hematoxylin469.4S100B, ACTC1, F13A1
151,25 dihydroxy vitamin d3469.3LIF, CSF1R, CSF1
16cytarabine46 52 1211.3LIF, CSF1R, CSF1
17methylcellulose469.3CSF1, LIF, MYB
18nitroblue tetrazolium469.2MYB, LIF, CSF1R
19phorbol469.2MYB, CSF1R, CSF1
20choline46 25 1211.2S100B, LIF, MYB
21agar469.1CSF1, CSF1R, LIF
22heparin46 30 25 1212.1F13A1, LIF, CSF1, S100B
23chloramphenicol46 3 52 1212.1MYB, CSF1, S100B
24dmso469.1MYB, CSF1R, CSF1
25wortmannin469.0LIF, CSF1R, CSF1, S100B
26thymidine46 259.8MYB, LIF, CSF1, S100B
27methionine468.8MYB, LIF, CSF1R, S100B
2812-o-tetradecanoylphorbol 13-acetate468.8MYB, LIF, CSF1R, CSF1
29iron46 259.7S100B, ACTC1, MYB, F13A1
30oligonucleotide468.7F13A1, MYB, LIF, CSF1R
31matrigel468.7CSF1, ACTC1, LIF
32glycogen46 259.7LIF, ACTC1, CSF1, S100B
33cycloheximide468.7MYB, LIF, CSF1R, CSF1
34creatinine468.6LIF, ACTC1, CSF1, S100B
35testosterone46 62 25 1211.5LIF, ACTC1, CSF1, S100B
36cyclosporin a46 30 6210.5MYB, LIF, ACTC1, S100B
37lipid468.3MYB, LIF, CSF1R, S100B, CD1A
38cysteine468.3MYB, LIF, CSF1R, CSF1, S100B
39arginine468.2MYB, LIF, CSF1, S100B
40imatinib46 52 1210.1MYB, ACTC1, CSF1R, CSF1, S100B
41serine468.0MYB, LIF, CSF1R, CSF1, S100B
42steroid468.0MYB, LIF, ACTC1, CSF1R, S100B
43paraffin467.9F13A1, LIF, ACTC1, CSF1R, CSF1, S100B
44calcium46 52 25 1210.8F13A1, MYB, LIF, ACTC1, S100B, CD207
45dexamethasone46 52 30 1210.6MYB, LIF, ACTC1, CSF1R, CSF1, S100B
46retinoic acid46 258.6MYB, LIF, ACTC1, CSF1R, CSF1, S100B
47tyrosine467.5MYB, LIF, ACTC1, CSF1R, CSF1, S100B
48progesterone46 30 62 25 1211.3S100B, F13A1, MYB, LIF, ACTC1, CSF1R
49vegf467.3F13A1, MYB, LIF, ACTC1, CSF1R, CSF1
50estrogen467.3F13A1, MYB, LIF, ACTC1, CSF1R, CSF1

GO Terms for genes affiliated with Histiocytosis

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17Gene Ontology
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Cellular components related to Histiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3S100B, CSF1, ACTC1, LIF

Biological processes related to Histiocytosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage differentiationGO:0456519.6CSF1, LIF
2macrophage differentiationGO:0302259.6CSF1, CSF1R
3osteoclast differentiationGO:0303169.5CSF1R, CSF1
4hemopoiesisGO:0300979.5CSF1, CSF1R
5positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.3CSF1R, LIF
6cell proliferationGO:0082838.8S100B, CSF1, CSF1R
7positive regulation of cell proliferationGO:0082848.7S100B, CSF1, CSF1R, LIF

Products for genes affiliated with Histiocytosis

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Sources for Histiocytosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet