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Histiocytosis malady
5 drugs, 100 genes, 11 tissues, 1038 related diseases, 25 phenotypes, 92 articles, clinical trials.

Summaries for Histiocytosis

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6Disease Ontology, 44Wikipedia, 22MalaCards
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Wikipedia: In medicine, histiocytosis refers to an excessive number of histiocytes, (tissue macrophages), and is...44 more...

MalaCards: Histiocytosis, also known as hand-schuller-christian syndrome, is related to langerhans-cell histiocytosis and malignant histiocytosis. An important gene associated with Histiocytosis is CD207 (CD207 molecule, langerin), and among its related pathways are Type I diabetes mellitus and RAR-Gamma-RXR-Alpha Degradation. The drugs etoposide and vinblastine sulfate and the compounds cyclophosphamide and ly294002 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spleen and liver, and related mouse phenotypes are craniofacial and endocrine/exocrine gland.

Disease Ontology: A reticuloendotheliosis that is characterized by an excessive number of histiocytes.6

Aliases & Descriptions for Histiocytosis

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 30NIH Rare Diseases, 27NCIt, 40SNOMED-CT, 24MeSH
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Aliases & Descriptions:

histiocytosis 6 8 32 43
hand-schuller-christian syndrome 30
hand schuller christian disease 6
hand-schuller-christian disease 30
histiocytosis, langerhans-cell 43
chronic histiocytosis x 6

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NCIt27 C3106

Related Diseases for Histiocytosis

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13GeneCards, 14GeneDecks
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Diseases related to histiocytosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1035)
idRelated DiseaseScoreTop Affiliating Genes
1langerhans-cell histiocytosis37.2S100A1, S100B, F13A1, PDGFB
2malignant histiocytosis33.0SERPINA1, SERPINA3, MYB, UCHL1, IL1A, IL1B
3non-langerhans-cell histiocytosis32.6CD163, F13A1, ACTC1
4rosai-dorfman disease31.5SERPINA3, S100A1, S100B, FSCN1, CD163, CTSD
5gaucher's disease31.1S100B, CD163, IL1R1, F2, TNF, TNFRSF11B
6juvenile xanthogranuloma30.6KIT, S100B, FSCN1, F13A1, STAB1
7letterer-siwe disease29.9RARA, LIF, S100B, FSCN1, CD1A, CD207
8langerhans cell sarcoma29.9S100B, CD1A, CD207
9erdheim-chester disease29.3S100B, IL1B, CCR6, CCR7, IGF1, SST
10idiopathic pulmonary fibrosis28.0S100A1, IL1A, IL1B, IL1R1, IL1RN, CCL22
11protein-losing enteropathy27.7INS, TP53, TNF, SST
12acute monocytic leukemia27.6RARA, CD1A, CD40, FLT3, TP53, TNF
13hemophagocytic lymphohistiocytosis27.4NCAM1, IL2, GPT, IFNG, F2, TNF
14fibromatosis27.3KIT, VIM, S100A1, CD163, MKI67, IL1B
15convulsions27.3IL1B, IL1R1, APOE, GPT, F2, CRH
16hepatitis27.1SERPINA1, GPT, IFNA1, F2, ALB, PDGFB
17aplastic anemia26.6KITLG, FLT3LG, FLT3, IL11, IL3, IFNG
18diabetes insipidus26.4S100B, AVP, CD1A, INS, IGF1, TRH
19splenomegaly26.3LCAT, JAK2, ITGAX, IL10, APOE, GPT
20monocytic leukemia25.6VIM, RARA, LIF, CD1A, CD40, ITGAL
21lymphoblastic lymphoma25.5NCAM1, VIM, CD4, MKI67, TRB@, TP53
22hodgkin's lymphoma25.1CFLAR, FSCN1, JAK2, CD40, CD68, FLT3
23anaplastic large cell lymphoma24.7KIT, SERPINA1, SERPINA3, CFLAR, FSCN1, CD4
24b-cell lymphomas24.5CFLAR, FSCN1, JAK2, CD40, ITGAL, MKI67
25sinusitis23.9SERPINA3, VIM, S100A1, AVP, CD4, CD40
26non-hodgkin lymphoma23.9KITLG, MYB, CFLAR, FSCN1, JAK2, CD40
27pulmonary fibrosis22.4SERPINA1, VIM, CLEC12A, S100A1, S100A9, CFLAR
28sarcoidosis20.0SERPINA3, VIM, CLEC12A, S100A9, CD4, CD207
29multiple myeloma20.0NCAM1, KIT, KITLG, LIF, CFLAR, JAK2
30nephropathy19.7KITLG, SERPINA1, RARA, LIF, CLEC12A, LCAT
31anemia19.6NCAM1, KIT, KITLG, MYB, LIF, LCAT
32cholesterol17.8KITLG, SERPINA1, SERPINA3, VIM, MYB, RARA
33fibrosis17.8KIT, KITLG, SERPINA1, SERPINA3, VIM, RARA
34myeloma17.3NCAM1, KIT, KITLG, RARA, LIF, UCHL1
35thyroiditis16.3NCAM1, KIT, KITLG, SERPINA1, VIM, RARA
36leukemia15.3NCAM1, KIT, KITLG, SERPINA3, VIM, MYB
37pigmented villonodular synovitis13.9CD68, TNFRSF11B, CSF1, CSF1R
38adult-onset still's disease13.9IL1R1, CRP, CSF1
39sweat gland carcinoma13.9S100A1, S100B, TP53, ACTC1
40meningococcemia13.9LIF, IL1A, IL1B, IL1RN
41chronic infantile neurological cutaneous articular syndrome13.9IL1B, IL1R1, IL1RN, CRP
42vulvar vestibulitis syndrome13.8IL1B, IL1R1, IL1RN, TNF
43cystic fibrosis13.8RARA, CTSD, PRL
44euthyroid sick syndrome13.8IL1B, GPT, ALB, TRH
45rheumatoid arthritis13.8IL1R1, IL1RN, CRP, LTA
46plasma cell leukemia13.8NCAM1, CD40, IFNA1, CSF1
47blau syndrome13.8IL10, IL1B, TNF, CSF1
48pilocytic astrocytoma13.8S100A1, S100B, MKI67, TP53, CTSD, PML
49toxic epidermal necrolysis13.8CD68, IL2, CCL22, F13A1, TNF
50pulmonary vein stenosis13.8MKI67, ACTC1, PECAM1

Graphical network of the top 20 diseases related to histiocytosis:



Graphical network of diseases related to histiocytosis

Clinical Features for Histiocytosis

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Drugs & Therapeutics for Histiocytosis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 etoposide, etoposide phosphate, thalidomide, vinblastine, vinblastine sulfate

Genetic Tests for Histiocytosis

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Anatomical Context for Histiocytosis

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22MalaCards
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MalaCards organs/tissues related to histiocytosis:

22
Lymph node, Spleen, Liver, Thyroid, Skin, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Pituitary

Phenotypes for genes affiliated with Histiocytosis

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25MGI
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MGI Mouse Phenotypes related to histiocytosis:

25 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1craniofacial phenotypeMP:000538210.1CSF1, NOTCH1, IL17A, KITLG, KIT, CSF2
2endocrine/exocrine gland phenotypeMP:000537910.1CSF1R, PROX1, LTA, PTPN6, TRH, CASP8
3reproductive system phenotypeMP:00053899.5SMPD1, PDGFB, PRL, CSF1, CSF1R, CSF2
4no phenotypic analysisMP:00030129.2PML, PDGFB, SST, TP53, IGKC, FADD
5embryogenesis phenotypeMP:00053809.0CSF2, PRL, NOTCH1, F2, FADD, CFLAR
6liver/biliary system phenotypeMP:00053708.9IL2, IFNG, TRB@, TP53, PTPRC, SMPD1
7integument phenotypeMP:00107718.4PDPN, ACPP, PRL, CSF1, CSF1R, CSF2
8skeleton phenotypeMP:00053908.3PTPN6, PTPRC, NOTCH1, PDPN, CSF1, CSF1R
9hematopoietic system phenotypeMP:00053978.0IL17A, CSF1R, CSF2, PML, SLC29A3, ADA
10nervous system phenotypeMP:00036317.6TRB@, PTPN6, PTPRC, OAT, CTSD, CRH
11tumorigenesisMP:00020066.8TRB@, TP53, TNF, PTPRC, NOTCH1, PRL
12normal phenotypeMP:00028736.7CRH, SST, PTPRC, TRB@, ALB, NOTCH1
13immune system phenotypeMP:00053875.8KIT, FLT3, IL2, FADD, CCR6, IFNG
14mortality/agingMP:0010768INFTNFRSF11B, CSF1, CSF1R, CSF2, PML, SLC29A3
15cellular phenotypeMP:0005384INFCCR6, PTPN6, PTPRC, CTSD, SMPD1, CRH
16growth/size phenotypeMP:0005378INFTRH, LTA, ACTC1, TFRC, PROX1, CSF1R
17behavior/neurological phenotypeMP:0005386INFPDPN, SMPD1, CTSD, OAT, SST, LTA
18respiratory system phenotypeMP:0005388INFLIF, ITPA, , F13A1, PTPN6, PTPRC
19renal/urinary system phenotypeMP:0005367INFPTPRC, OAT, NOTCH1, PDGFB, STAB1,
20vision/eye phenotypeMP:0005391INFIFNG, TP53, TNF, OAT, CTSD, NOTCH1
21homeostasis/metabolism phenotypeMP:0005376INFKIT, KITLG, VIM, LCAT, S100A9, CFLAR
22limbs/digits/tail phenotypeMP:0005371INFCSF1R, CSF1, LTA, PTPN6, TNFRSF11B,
23digestive/alimentary phenotypeMP:0005381INFKIT, KITLG, PTPN6, PTPRC, SST, CTSD
24muscle phenotypeMP:0005369INFTP53, TNF, NOTCH1, PDGFB, PDLIM3, PDPN
25cardiovascular system phenotypeMP:0005385INFKIT, KITLG, VIM, MYB, IL1R1, IL1RN

Publications for genes affiliated with Histiocytosis

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35PubMed
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Articles related to histiocytosis:

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idTitleAuthorsYearAffiliating Genes
1Neither IL-17A mRNA nor IL-17A protein are detectable in Langerhans cell histiocytosis lesions. (21654633)Peters T.L.... Allen C.E.2011IL17A
2A role for ITPA variants in the clinical course of pu lmonary Langerhans' cell histiocytosis? (20930204)Bakker J.A.... Drent M.2010ITPA
3Importance of multi-lineage hematologic involvement a nd hypoalbuminemia at diagnosis in patients with 'risk-organ' multi-s ystem Langerhans cell histiocytosis. (20418784)Braier J.L.... Scopinaro M.2010ALB
4Possible acceleration of regression by antibiotic tre atment in benign cephalic histiocytosis with infiltration of CD11a/CD11c+ macro phages. (20574620)Quist S.R.... Gollnick H.P.2010ITGAL, ITGAX
5Mutations in SLC29A3, encoding an equilibrative nucle oside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad his tiocytosis) and familial Rosai-Dorfman disease. (20140240)Morgan N.V.... Maher E.R.2010SLC29A3
6Fibroblastic rheumatism: fibromatosis rather than non -Langerhans cell histiocytosis. (19615014)Kluger N.... Fraitag S.2010F13A1, ACTC1, CD163
7A Case of a Korean Adult Affected by Type B Niemann-Pick Disease: Secondary Sea-blue Histiocytosis and Molecular Characterization. (19411774)Cho Y.U.... Yoo H.W.2009SMPD1
8Absence of FLT3 and JAK2 (V617F) mutations in Langerh ans cell histiocytosis. (19395028)Abedalthagafi M.... Ozdemirli M.2009JAK2, FLT3
9Histiocyte-rich pleomorphic mastocytoma: an uncommon variant mimicking juvenile xanthogranuloma and Langerhans cell histiocytosis. (19602070)Tran D.T.... Argenyi Z.B.2009KIT
10Bronchoalveolar lavage fluid analysis provides diagnostic information on pulmonary Langerhans cell histiocytosis. (19443993)Takizawa Y.... Kawanami O.2009CD207
11In vivo transformation of mouse conventional CD8alpha + dendritic cells leads to progressive multisystem histiocytosis. (18029555)Steiner Q.G.... Acha-Orbea H.2008CD207
12ALK+ histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy. (18660380)Chan J.K.... Chow C.W.2008ALK, CD207
13Solitary Langerhans cell histiocytosis orbital lesion : case report and review of the literature. (18936863)Ulivieri S.... Filosomi G.2008CD1A
14Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1. (17874453)Rodig S.J.... Aster J.C.2008NOTCH1
15Immunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders. (18277880)Lau S.K.... Weiss L.M.2008CD1A, CD207
16Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. (18157139)Coury F.... Delprat C.2008IL17A
17Immunohistochemical analysis of langerin in langerhans cell histiocytosis and pulmonary inflammatory and infectious diseases. (17527085)Sholl L.M.... Padera R.F.2007CD1A, CD207
18Expansion of regulatory T cells in patients with Langerhans cell histiocytosis. (17696642)Senechal B.... Geissmann F.2007IL10
19Langerhans' cell histiocytosis with multisystem involvement in an adult. (17953644)Liu Y.H.... Fang K.2007S100B
20Clinical spectrum of cutaneous Langerhans' cell histiocytosis mimicking various diseases. (16585988)Querings K.... Balda B.R.2006CD207
21High serum values of soluble CD154, IL-2 receptor, RANKL and osteoprotegerin in Langerhans cell histiocytosis. (16358318)Ishii R.... Imashuku S.2006TNFRSF11B
22Specific polymorphisms of cytokine genes are associated with different risks to develop single-system or multi-system childhood Langerhans cell histiocytosis. (16487180)De Filippi P.... Arico M.2006IL4, IFNG
23A case of pulmonary langerhans cell histiocytosis presenting disappearance of coalescing air wall cysts after smoking cessation (16050471)Okubo F.... Kumamoto T.2005CD68
24Diagnostic relevance of Langerin detection in cells from bronchoalveolar lavage of patients with pulmonary Langerhans cell histiocytosis, sarcoidosis and idiopathic pulmonary fibrosis. (14722767)Smetana K.... Gabius H.J.2004CD207, CLEC12A
25Sinus histiocytosis with massive lymphadenopathy and Langerhans cell histiocytosis express the cellular adhesion molecule CD31. (12653580)Slone S.P.... Buchino J.J.2003PECAM1
26Atypical generalized eruptive histiocytosis associated with acute monocytic leukemia. (14576638)Klemke C.D.... Goerdt S.2003CD1A
27Serum levels of interleukin-1 receptor antagonist and tumor necrosis factor-alpha are elevated in children with Langerhans cell histiocytosis. (12794527)Rosso D.A.... Braier J.L.2003TNF, IL1R1, IL1RN
28Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis. (12642342)Fleming M.D.... Rollins B.J.2003CCR6, CCR7
29Langerhans cell histiocytosis: an evaluation of histopathological parameters, demonstration of proliferation by Ki-67 and mitotic bodies. (12716386)Bank M.I.... Petersen B.L.2003MKI67
30Pulmonary Langerhans cell Histiocytosis. (11587096)Harari S.... Comel A.2001CD1C
31Abundant expression of CD40 and CD40-ligand (CD154) in paediatric Langerhans cell histiocytosis lesions. (11044648)Egeler R.M.... Claassen E.2000CD40
32CD101 expression by Langerhans cell histiocytosis cells. (10692025)Bouloc A.... Bagot M.2000CD101
33Angiotensin-converting enzyme, transforming growth factor beta(1), and interleukin 11 in the osteolytic lesions of Langerhans cell histiocytosis. (10975922)Brown R.E.2000IL11
34Simultaneous occurrence of Hodgkin's disease, nodal L angerhans' cell histiocytosis and multiple myeloma IgA(kappa). (10190308)Ibarrola de AndrAcs C.... MartA-nez-GonzA!lez M.A.1999IGKC
35Evidence that Langerhans cells in adult pulmonary Langerhans cell histiocytosis are mature dendritic cells: importance of the cytokine microenvironment. (10477625)Tazi A.... Soler P.1999TNF, IL10
36Dynamic endocrine testing and magnetic resonance imaging in the long-term follow-up of childhood langerhans cell histiocytosis. (9745408)Maghnie M.... AricA^ M.1998PRL, CRH, TRH
37Hepatic manifestation of malignant histiocytosis: a case study. (9055006)Chow W.C.... Tan P.1996F2
38Indeterminate cell histiocytosis--a clinicopathological entity with features of both X- and non-X histiocytosis. (8731682)Sidoroff A.... Smith N.1996F13A1
39Monokine expression in Langerhans' cell histiocytosis and sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) (8691347)Foss H.D.... Stein H.1996S100A1
40Successful treatment of two children with Langerhans' cell histiocytosis with 2'-deoxycoformycin. (8846128)McCowage G.B.... Kurtzberg J.1996ADA
41Functional defect in cells involved in Langerhans cell histiocytosis. (8534124)Yu R.C.... Chu A.C.1995IL1B
42Interleukin-2 therapy of Langerhans cell histiocytosi s. (8563240)Hirose M.... Kuroda Y.1995IL2
43Cathepsin D and E co-expression in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and Langerhans' cell histiocytosis: further evidences of a phenotypic overlap between these histiocytic disorders. (8055153)Paulli M.... Bonetti F.1994CTSD
44Anterior pituitary function and computed tomography/magnetic resonance imaging in patients with Langerhans cell histiocytosis and diabetes insipidus. (8412998)Broadbent V.... Kendall B.1993INS
45Surface phenotype of Langerhans cells and lymphocytes in granulomatous lesions from patients with pulmonary histiocytosis X. (8503566)Tazi A.... Soler P.1993CD4
46Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35. (1313990)Nezelof C.... Terrier-Lacombe M.J.1992MYB, TFRC, CSF1R
47Histologic and immunohistochemical study comparing xanthoma disseminatum and histiocytosis X. (1519935)Zelger B.... Wilson-Jones E.1992F13A1
48Medullary histiocytosis following treatment of severe aplastic anemia with recombinant human interleukin-3 in combination with antilymphocyte globulin, cyclosporin A, and methylprednisolone. (1932305)Herrmann F.... Mertelsmann R.H.1991IL3
49Histiocytosis X of the vulva: a case report and review of the literature. (2406669)Otis C.N.... Powell J.L.1990S100B
50Histiocytosis X. S-100 protein, peanut agglutinin, and transmission electron microscopy study. (2239828)Ye F.... Dong H.J.1990S100A1

Expression for genes affiliated with Histiocytosis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Histiocytosis

Pathways for genes affiliated with Histiocytosis

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20KEGG, 36QIAGEN, 38Reactome, 37R&D Systems, 10EMD Millipore, 41Thomson Reuters
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Pathways related to histiocytosis according to GeneDecks:

(show top 50)    (show all 112)
idPathwayScoreTop Affiliating Genes
1Type I diabetes mellitus2010.1INS, LTA, TNF, IL1A, IFNG, IL1B
2RAR-Gamma-RXR-Alpha Degradation3610.0CSF2, LIF, LTA, CSF1, CCL22, IL3
3IL-6 Pathway3610.0IL10, CSF2, IL3, IL11, CSF1, IL4
4LDL Oxidation in Atherogenesis3610.0TNF, SMPD1, CSF1, IL1B, CD68
5Rheumatoid arthritis2010.0TNF, IL1A, IL17A, IL1B, CSF2, ITGAL
6Immune System389.9S100B, NCAM1, PML, CTSD, CD207, CD40
7SUMO Pathway369.9IL1A, LTA, TNF, TP53, IL1R1, IL1B
8Malaria209.9ITGAL, IL10, IL1B, IFNG, TNF, PECAM1
9Pathways in cancer209.8TP53, RARA, FADD, FLT3, CSF1R, PML
10Leishmaniasis209.7TNF, PTPN6, JAK2, IL10, IL1A, IL4
11Apoptosis209.7FADD, CFLAR, IL1A, IL1R1, IL3, TNF
12MIF Regulation of Innate Immune Cells369.5LIF, IL11, IL10, IL1A, IL2, LTA
13MIF Mediated Glucocorticoid Regulation369.5IL1B, IL2, LIF, IL1A, IL11, IL3
14all-trans-Retinoic Acid Signaling in Brain369.5IL2, IL1B, IL1A, IL10, LIF, RARA
15PGC1Alpha Pathway369.5IL1B, IL1A, IL11, IL2, IL3, IL4
16Cytokine Network369.5TNF, IFNG, IFNA1, IL4, IL3, IL2
17Tuberculosis209.4CTSD, CASP8, IFNG, IFNA1, TNF, IL1B
18PEDF Induced Signaling369.4LIF, CSF2, CSF1, LTA, TNF, CASP8
19NFAT Signaling and Lymphocyte Interactions369.3CCL22, CD4, IL11, IL1A, IL2, IL3
20Th1 Differentiation379.3LTA, IFNG, CD4, IL10, IL2, TNF
21Jak-STAT signaling pathway209.3JAK2, IL10, PRL, IL11, IL2, IFNA1
22Endothelin-1 Signaling Pathway369.3IL10, IL2, IL3, IL4, ALK, IL11
23T cell receptor signaling pathway209.1IL2, PTPRC, PTPN6, CSF2, TNF, IFNG
24NF-KappaB (p50-p65) Pathway369.1PDGFB, TNF, LTA, KITLG, IL1A, IL2
25NF-KappaB Family Pathway369.1IL1B, IL1R1, IL3, LTA, PDGFB, TNF
26Regulation of eIF4 and p70S6K369.0ITGAX, IL11, IL1A, IL2, IL3, IL4
27Apoptotic Pathways in Synovial Fibroblasts369.0KIT, LTA, PDGFB, TNF, TP53, CFLAR
28Cellular Apoptosis Pathway368.9PML, IL2, PDGFB, TNF, TP53, CASP8
29SOCS Pathway368.8IL10, INS, JAK2, IL1A, CCL22, IL4
30Hematopoietic cell lineage208.8CSF2, FLT3LG, KITLG, CD4, CD1A, CD1C
31JNK Pathway368.8FLT3, CD4, KITLG, TP53, IL2, PDGFB
32Akt Signaling368.7CSF2, KIT, LTA, PDGFB, TNFRSF8, TNF
33PAK Pathway368.7IL1B, IL1A, IL11, IL10, LIF, KIT
34TGF-Beta Pathway368.7IL1A, KITLG, CD4, IL10, IL11, PDGFB
35ERK Signaling368.7IL10, KIT, KITLG, IL2, IL3, IL4
3614-3-3 Induced Intracellular Signaling368.7PDGFB, CSF1R, KITLG, FLT3, IL3, IGF1
37STAT3 Pathway368.6IL1B, IL1A, IL11, IL10, CD4, JAK2
38MAPK Family Pathway368.5KITLG, CD4, IL10, IL11, IL1A, IL1B
39Molecular Mechanisms of Cancer368.4CSF1R, LTA, PDGFB, NOTCH1, TNFRSF8, TP53
40Cytokine-cytokine receptor interaction208.4KIT, KITLG, LIF, CD40, FLT3LG, FLT3
41Paxillin Interactions368.3ITGAL, PDGFB, KIT, ALK, KITLG, IL3
42Pancreatic Adenocarcinoma368.3IGF1, IL2, ALK, TP53, NOTCH1, IL3
43MAPK Signaling368.0IL1R1, IL2, IGF1, ALK, TP53, TNF
44Antioxidant Action of Vitamin-C367.9IL3, IL2, IL1R1, IL1B, IL1A, IL11
45Tec Kinases Signaling367.9KITLG, JAK2, CD4, ITGAL, ITGAX, IL10
46p38 Signaling367.7IL1B, IL1A, IL11, IL10, FLT3, CD4
47JAK-STAT Pathway367.4KIT, ALK, PDGFB, PRL, CSF1R, F2
48Rho Family GTPases367.2CSF2, CSF1R, CSF1, LTA, PDGFB, ALK
49Transcription Role of VDR in regulation of genes involved in osteoporosis10INFIGF1, TNFRSF11B, TNF, IFNG, , IL1B
50Transcription_Role of VDR in regulation of genes involved in osteoporosis41INFIGF1, , IL1A, IL1B, IFNG, TNF

Compounds for genes affiliated with Histiocytosis

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32Novoseek , 34PharmGKB, 9DrugBank, 42Tocris Bioscience, 18HMDB
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Compounds related to histiocytosis according to GeneDecks:

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idCompoundScoreTop Affiliating Genes
1cyclophosphamide32 34 9 9 13.2ITGAL, FLT3LG, TRB@
2ly29400232 10.2RARA, CFLAR, IL10, IL17A, IL1B, IL4
3p00332 9.9KIT, SERPINA1, S100B, MKI67, FLT3, IL1R1
4ionomycin32 9.8SERPINA3, CD40, IL3, PTPRC, CSF2
5threonine32 9.8AVP, CD4, FLT3, CASP8, LTA, CSF1R
6progesterone32 42 9 18 9 13.6NCAM1, KIT, SERPINA3, MYB, RARA, LIF
7tgf beta132 9.6KITLG, RARA, LIF, MKI67, FLT3, IL10
8infliximab32 9 9 11.5IL10, IL11, IL17A, IL1B, IL1R1, IL1RN
9endotoxin32 9.4LIF, S100A9, JAK2, CD40, ITGAL, IL1R1
10methylcellulose32 9.2KIT, KITLG, MYB, LIF, FLT3LG, FLT3
115fluorouracil32 9.2KIT, KITLG, LIF, CFLAR, MKI67, IL11
12pge232 9.1LIF, CD4, IL17A, IL1A, IL1R1, IL1RN
13calcitriol32 42 9 18 9 13.1KITLG, RARA, LIF, S100A9, ITGAL, IL11
14epinephrine32 9 18 9 12.0KITLG, JAK2, INS, IL11, IL1A, IL1RN
15cysteine32 9.0SERPINA1, SERPINA3, MYB, RARA, LIF, CLEC12A
16rapamycin32 42 10.0KIT, KITLG, VIM, MYB, CFLAR, JAK2
17ascorbic acid32 18 9.9LIF, LCAT, S100B, JAK2, IL1A, IL1R1
18gm-csf32 8.9KITLG, LIF, IL10, IL11, IL1A, IL1B
19prednisolone32 9 9 10.6KITLG, CD40, ITGAL, IL10, IL1R1, IL1RN
20paclitaxel32 34 9 9 11.5KIT, KITLG, VIM, RARA, LIF, S100B
21acth32 8.5SERPINA1, AVP, INS, IL11, IL1A, IL1B
22rantes32 8.3KITLG, LIF, CD4, CD40, ITGAL, IL11
23doxorubicin32 34 9 9 11.2NCAM1, KIT, KITLG, VIM, MYB, CFLAR
24cytarabine32 34 9 9 11.0KIT, KITLG, VIM, LIF, FLT3, IL11
25tacrolimus32 34 9 9 11.0CD40, ITGAL, INS, IL10, IL11, IL17A
26nitric oxide32 9 18 9 10.9NCAM1, KIT, KITLG, SERPINA1, RARA, LIF
27fmlp32 7.6SERPINA3, VIM, LIF, S100A9, ITGAL, ITGAX
28oligonucleotide32 7.6KIT, SERPINA1, SERPINA3, VIM, MYB, RARA
29neopterin32 7.5CD4, CD40, IL10, IL1A, IL1B, IL1R1
30phosphatidylinositol32 7.3NCAM1, KIT, KITLG, RARA, LIF, CFLAR
31histamine32 18 7.8NCAM1, KIT, KITLG, VIM, CD40, IL10
32lactate32 6.5NCAM1, KIT, KITLG, VIM, LIF, S100B
33hydrocortisone32 9 9 8.5KITLG, VIM, LIF, CD40, INS, IL10
34dexamethasone32 42 34 9 9 8.9NCAM1, KITLG, SERPINA3, VIM, MYB, RARA
35tyrosine32 4.1NCAM1, KIT, KITLG, SERPINA1, MYB, RARA
36testosterone32 9 18 9 INFNCAM1, KIT, KITLG, VIM, RARA, LIF
37vegf32 INFNCAM1, KIT, KITLG, LIF, S100B, CFLAR
38biotin32 9 18 9 INFKITLG, VIM, S100A1, CD40, MKI67,
39aspartate32 INFVIM, RARA, S100B, IL11, , F2
40acetylcholine32 9 18 9 INFNCAM1, SERPINA3, VIM, LIF, S100A1, S100B
41cycloheximide32 INFKIT, KITLG, VIM, MYB, RARA, LIF
42paraffin32 INFNCAM1, KIT, KITLG, SERPINA1, SERPINA3, VIM
43h2o232 INFKITLG, SERPINA1, MYB, LIF, CLEC12A, S100A9
44indomethacin32 9 9 INFVIM, JAK2, CD40, ITGAX, IL11, IL17A
45vitamin d32 INFVIM, RARA, IL10, IL11, IL1A, IL1R1
46cyclosporin a32 42 INFKITLG, MYB, LIF, S100B, CFLAR, JAK2
47actinomycin d32 INFKIT, KITLG, VIM, MYB, RARA, LIF
48cholesterol32 9 18 9 INFKITLG, SERPINA1, SERPINA3, LIF, LCAT, S100A9
49alanine32 INFNCAM1, KITLG, SERPINA3, VIM, MYB, RARA
50serine32 INFNCAM1, KIT, KITLG, SERPINA1, SERPINA3, VIM

GO Terms for genes affiliated with Histiocytosis

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Sources:
12Gene Ontology
See all sources

Cellular components related to histiocytosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complexGO:03126410.2CFLAR, FADD, CASP8
2cell surfaceGO:0099869.6CSF1R, PDGFB, TNF, IL1R1, IL1A, FLT3
3platelet alpha granule lumenGO:0310939.4PDGFB, F13A1, ALB, IGF1, SERPINA1
4secretory granuleGO:0301419.1TF, ACPP, TRH, IL1B, INS, AVP
5external side of plasma membraneGO:0098978.5ADA, PTPRC, TNF, IFNG, CCR7, IL4
6extracellular regionGO:005576INFLYZ, NCAM1, , IL3, IL2, IL1R1
7extracellular spaceGO:005615INFADA, IL3, IL2, IL1RN, IL1B, IL1A
8plasma membraneGO:005886INFTNFRSF8, TNF, TRH, F2, IGKC, CCR7

Biological processes related to histiocytosis according to GeneDecks:

(show top 50)    (show all 72)
idNameGO IDScoreTop Affiliating Genes
1chronic inflammatory response to antigenic stimulusGO:00243910.6IL1RN, IL1B
2positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.6IFNG, CD40, LIF, KIT
3positive regulation of calcidiol 1-monooxygenase activityGO:06055910.5TNF, IFNG, IL1B
4positive regulation of chemokine biosynthetic processGO:04508010.4TNF, IFNG, IL4, IL1B
5positive regulation of osteoclast differentiationGO:04567210.4CSF1, TNF, IFNG, IL17A
6acute-phase responseGO:00695310.4CRP, F2, IL1RN, INS, CD163, SERPINA3
7positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.4TNF, CASP8, CCR7, FADD, IL1B, IL1A
8response to hypoxiaGO:00166610.2ADA, PML, LTA, PDGFB, CRP, TNF
9negative regulation of growth of symbiont in hostGO:04413010.2LTA, TNF, IFNG, IL10
10hemopoiesisGO:03009710.2CSF1R, CSF1, PDGFB, IL10, FLT3, KITLG
11positive regulation of isotype switching to IgG isotypesGO:04830410.1PTPRC, IFNG, IL4, IL2, CD40
12positive regulation of MAP kinase activityGO:04340610.1PDGFB, TNF, FLT3, CD40, KITLG
13response to gamma radiationGO:01033210.1PML, PTPRC, TP53, IL1B, IL1A
14positive regulation of nitric oxide biosynthetic processGO:04542910.0TNF, IFNG, IL1B, INS, JAK2
15positive regulation of B cell proliferationGO:03089010.0ADA, PTPRC, IL4, IL2, CD40
16cell proliferationGO:00828310.0CSF1R, CSF1, PRL, PDPN, PTPN6, TP53
17defense response to virusGO:05160710.0PTPRC, IFNG, FADD, ITGAX, CD40, CD207
18response to drugGO:04249310.0ACTC1, LTA, PDGFB, SMPD1, SST, TNFRSF11B
19peptidyl-tyrosine phosphorylationGO:0181089.9CSF1R, PDGFB, PTPN6, FLT3, JAK2, KIT
20positive regulation of cell migrationGO:0303359.9CSF1R, CSF1, PDPN, PDGFB, NOTCH1, INS
21positive regulation of mitosisGO:0458409.9PDGFB, TNF, IGF1, IL1B, IL1A, INS
22positive regulation of ERK1 and ERK2 cascadeGO:0703749.8CSF1R, PDGFB, TNF, CCR7, IL1B, IL1A
23response to lipopolysaccharideGO:0324969.8LTA, NOTCH1, CASP8, CCR7, IL1A, JAK2
24embryonic hemopoiesisGO:0351629.8KIT, KITLG, FLT3LG, IL3
25positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8TNF, IL4, IL1B, IL10, JAK2, KIT
26cytokine-mediated signaling pathwayGO:0192219.7IFNG, PTPN6, CSF1R, PML, IL1B, IL1A
27response to ethanolGO:0454719.6ACTC1, TRH, CASP8, IL4, AVP, S100A9
28B cell differentiationGO:0301839.6PTPRC, IL4, IL11, IL10, FLT3
29positive regulation of T cell proliferationGO:0421029.5PTPRC, IFNG, IL4, IL1B, ITGAL
30positive regulation of DNA replicationGO:0457409.5CSF2, PDGFB, IGF1, IL3, INS, KITLG
31cell surface receptor signaling pathwayGO:0071669.5PRL, SST, PTPRC, F2, IFNG, IL1R1
32platelet degranulationGO:0025769.4PECAM1, TF, PDGFB, F13A1, ALB, IGF1
33platelet activationGO:0301689.3PECAM1, TF, PDGFB, F13A1, ALB, F2
34positive regulation of MAPK cascadeGO:0434109.2PDGFB, PTPRC, IGF1, IL11, INS, FLT3
35positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.2PDGFB, PTPN6, F2, IGF1, INS, FLT3
36positive regulation of apoptotic processGO:0430659.2SMPD1, PTPRC, TNFRSF8, TNF, TP53, FADD
37positive regulation of transcription from RNA polymerase II promoterGO:0459449.2FADD, IGF1, IFNG, TP53, TNF, NOTCH1
38cell-cell signalingGO:0072679.1IL3, CCL22, TRH, SST, LTA, STAB1
39positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.1CSF2, IGF1, IL4, IL3, IL2, JAK2
40inflammatory responseGO:0069549.1LYZ, SERPINA3, S100A9, CD40, ITGAL, IL10
41immune responseGO:0069559.1IL4, CCR6, CCL22, CCR7, IGKC, NOTCH1
42negative regulation of cell proliferationGO:0082858.9TNF, TNFRSF8, SST, PROX1, PML, TP53
43positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.6PDGFB, TP53, IGF1, IL3, IL11, INS
44apoptotic processGO:0069158.5CASP8, TP53, TNF, TNFRSF11B, PTPN6, ACTC1
45cellular component movementGO:0069288.4PDPN, IFNG, IGF1, CCR6, ITGAL, JAK2
46blood coagulationGO:0075968.3F13A1, TP53, PTPN6, PDGFB, TF, PECAM1
47positive regulation of cell proliferationGO:0082847.9CSF2, CSF1R, INS, FLT3, FLT3LG, JAK2
48signal transductionGO:0071657.8ALK, TRH, TNFRSF11B, TNFRSF8, SMPD1, CRH
49negative regulation of MAP kinase activityGO:043407INFSMPD1, PTPN6, , IL1B, UCHL1
50positive regulation of membrane protein ectodomain proteolysisGO:051044INFIL1B, , IFNG, TNF

Molecular functions related to histiocytosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.3IL1A, IL1B, IL1RN
2tumor necrosis factor receptor bindingGO:0051649.8LTA, TNF, CASP8, FADD
3protease bindingGO:0020209.8TNF, TP53, IL1R1, INS, SERPINA1, KIT
4cytokine activityGO:0051258.9KITLG, CSF2, CSF1, LTA, TNFRSF11B, TNF
5growth factor activityGO:0080838.7CSF2, CSF1, PDGFB, F2, IGF1, IL4
6protein bindingGO:005515INFTNF, TP53, CASP8, ALB, F2, IGF1

Sources for Histiocytosis

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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