MCID: HST010
MIFTS: 55

Histiocytosis malady

Rare diseases, Cancer diseases, Immune diseases categories

Aliases & Classifications for Histiocytosis

About this section

Aliases & Descriptions for Histiocytosis:

Name: Histiocytosis 8 10 44 61
Hand-Schuller-Christian Syndrome 42
Hand Schuller Christian Disease 8
 
Hand-Schuller-Christian Disease 42
Histiocytosis, Langerhans-Cell 61
Chronic Histiocytosis X 8


Classifications:



External Ids:

Disease Ontology8 DOID:3405
NCIt39 C3106
MeSH33 D015614

Summaries for Histiocytosis

About this section
Wikipedia:64 In medicine, histiocytosis refers to an excessive number of histiocytes, (tissue macrophages), and is... more...

MalaCards based summary: Histiocytosis, also known as hand-schuller-christian syndrome, is related to langerhans-cell histiocytosis and rosai-dorfman disease. An important gene associated with Histiocytosis is F13A1 (coagulation factor XIII, A1 polypeptide), and among its related pathways are Signaling events mediated by PTP1B and Integrins in angiogenesis. The drugs thalidomide and etoposide and the compounds mdms and aclarubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and bone marrow, and related mouse phenotypes are integument and cardiovascular system.

Disease Ontology:8 A lymphatic system disease that is characterized by an excessive number of histiocytes.

Related Diseases for Histiocytosis

About this section

Diseases in the Histiocytosis family:

Malignant Histiocytosis

Diseases related to Histiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 311)
idRelated DiseaseScoreTop Affiliating Genes
1langerhans-cell histiocytosis32.4F13A1, S100B
2rosai-dorfman disease31.8S100B
3malignant histiocytosis31.6CSF1, CSF1R, MYB
4juvenile xanthogranuloma31.3F13A1, S100B
5langerhans cell sarcoma30.9CD207
6myelodysplastic syndrome30.5CSF1R, CSF1
7chronic myelomonocytic leukemia30.4CSF1R, CSF1
8monocytic leukemia30.3CSF1, LIF
9leukemia30.3MYB, LIF, CSF1R, CSF1, CD1A
10arthritis30.1LIF, CSF1R, CSF1
11fibrous histiocytoma30.1F13A1, ACTC1, S100B
12acute myelomonocytic leukemia30.1CSF1R, CSF1
13acute leukemia30.0CSF1, CSF1R, MYB
14rheumatoid arthritis30.0F13A1, MYB, LIF, CSF1
15teratoma29.9ACTC1, LIF
16papilloma29.7ACTC1
17myeloid leukemia29.7CSF1, CSF1R, LIF, MYB
18osteoarthritis29.5F13A1, LIF, CSF1R, CSF1
19sarcoma29.5F13A1, ACTC1, CSF1R, CSF1, S100B, CD1A
20glioblastoma29.3S100B, CSF1R, MYB
21ipex syndrome29.2CD207, S100B, CSF1, LIF, MYB
22adenocarcinoma29.1CSF1R, ACTC1, LIF, MYB, F13A1
23benign cephalic histiocytosis10.6
24non-langerhans-cell histiocytosis10.6
25indeterminate cell histiocytosis10.6
26erdheim-chester disease10.5
27histiocytosis-lymphadenopathy plus syndrome10.5
28diabetes insipidus10.5
29thyroiditis10.5
30perineurioma10.5S100B
31progressive nodular histiocytosis10.4
32ganglioglioma10.4S100B
33adult pulmonary langerhans cell histiocytosis10.4
34b-cell lymphomas10.4
35hereditary progressive mucinous histiocytosis10.4
36niemann-pick disease10.3
37mediastinitis10.3
38cervicitis10.3
39virus associated hemophagocytic syndrome10.3
40mycosis fungoides10.3CD1A, F13A1
41pneumothorax10.3
42glomus tumor10.3ACTC1
43sea-blue histiocyte disease10.2
44pick disease10.2
45gaucher's disease10.2
46histiocytoma10.2
47alk+ histiocytosis10.2
48histiocytic sarcoma10.2
49marginal zone b-cell lymphoma10.2
50pigmented villonodular synovitis10.2CSF1, CSF1R

Graphical network of the top 20 diseases related to Histiocytosis:



Diseases related to histiocytosis

Symptoms for Histiocytosis

About this section

Drugs & Therapeutics for Histiocytosis

About this section

Drug clinical trials:

Search ClinicalTrials for Histiocytosis

Search NIH Clinical Center for Histiocytosis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Histiocytosis

About this section

Anatomical Context for Histiocytosis

About this section

MalaCards organs/tissues related to Histiocytosis:

31
Bone, T cells, Bone marrow, Lung, Thyroid, Skin, B cells, Liver, Myeloid, Lymph node, Monocytes, Pituitary, Spleen, Brain, Colon, Pancreas, Breast, Thymus, Spinal cord, Testes, Small intestine, Tonsil, Tongue, Eye, Cortex, Heart, Temporal lobe, Hypothalamus, Neutrophil

Animal Models for Histiocytosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Histiocytosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.8MYB, LIF, CSF1R, CSF1, S100B
2MP:00053857.8CSF1, ACTC1, LIF, MYB, F13A1
3MP:00053877.7MYB, LIF, CSF1R, CSF1, CD207, SLC29A3
4MP:00053977.5SLC29A3, F13A1, MYB, LIF, CSF1R, CSF1
5MP:00107686.9F13A1, MYB, LIF, ACTC1, CSF1R, CSF1
6MP:00053846.9MYB, LIF, ACTC1, CSF1R, CSF1, SLC29A3

Publications for Histiocytosis

About this section

Articles related to Histiocytosis:

(show top 50)    (show all 1379)
idTitleAuthorsYear
1
Langerhans cell histiocytosis in an adult with involvement of the calvarium, cerebral cortex and brainstem: discussion of pathophysiology and rationale for the use of intravenous immune globulin. (25873887)
2015
2
Severe pulmonary hypertension in adult pulmonary Langerhans cell histiocytosis: the effect of sildenafil as a bridge to lung transplantation. (25175135)
2014
3
Antiphospholipid syndrome and Langerhans cell histiocytosis: An exceptional association. (25867157)
2014
4
Skeletal involvement in Langerhans cell histiocytosis. (23907805)
2013
5
Rapid resolution of pulmonary Langerhans cell histiocytosis. (23749831)
2013
6
Multisystem Langerhans cell histiocytosis in adult. (22470214)
2012
7
Rosai-dorfman disease (sinus histiocytosis with massive lymphadenopathy) of the pancreas: third reported occurrence. (22864941)
2012
8
Concomitant occurrence of sinus histiocytosis with massive lymphadenopathy and nodal marginal zone lymphoma. (21366466)
2011
9
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. (21769315)
2011
10
Treatment of patients with hypothalamic-pituitary lesions as adult-onset Langerhans cell histiocytosis. (22015494)
2011
11
Case report: Langerhans cell histiocytosis presenting as massive cervical adenopathy and retropharyngeal thickening: importance of chest radiography and coordinated airway and anesthetic management. (20145506)
2010
12
Uncommon features of pulmonary Langerhans' cell histiocytosis: analysis of 11 cases and a review of the literature. (20193493)
2010
13
Cutaneous Langerhans cell histiocytosis in an elderly woman. (21062600)
2010
14
Langerhans cell histiocytosis with thyroid and lung involvement in a child: a case report. (20224443)
2010
15
A case of a Korean adult affected by type B Niemann-Pick disease: secondary sea-blue histiocytosis and molecular characterization]. (19411774)
2009
16
Japanese case of benign cephalic histiocytosis. (19207442)
2009
17
Cranial unifocal Langerhans cell histiocytosis in children. (19302861)
2009
18
Cerebral non-Langerhans cell histiocytosis in a 17-year-old patient with a headache: case report. (19363626)
2009
19
Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) of the pancreas: second case report. (19020944)
2009
20
A case of langerhans cell histiocytosis with anal fistula. (20505285)
2009
21
Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1. (17874453)
2008
22
Progressive nodular histiocytosis - A five-year follow up. (18424392)
2008
23
Sinus histiocytosis with massive lymphadenopathy (Rosai Dorfman disease): evidence for a dendritic cell derivation? (16761737)
2005
24
Indeterminate cell histiocytosis: a case report. (15481563)
2004
25
Primary histiocytic sarcoma of the spleen associated with erythrophagocytic histiocytosis. (12747473)
2003
26
Serum levels of interleukin-1 receptor antagonist and tumor necrosis factor-alpha are elevated in children with Langerhans cell histiocytosis. (12794527)
2003
27
Extranodal sinus histiocytosis (Rosai-Dorfman disease) of the brain parenchyma. (12601463)
2003
28
Sinus histiocytosis with massive lymphadenopathy: complicated by autoimmune hemolytic anemia. (14620195)
2003
29
Extranodal marginal zone B-cell lymphoma of the lacrimal gland associated with crystal-storing histiocytosis. (11772588)
2002
30
Benign cephalic histiocytosis progressing into juvenile xanthogranuloma: a non-Langerhans cell histiocytosis transforming under the influence of a virus? (10698221)
2000
31
Detection of Langerhans cell histiocytosis lesions with somatostatin analogue scintigraphy--a preliminary report. (11070478)
2000
32
Indeterminate-cell histiocytosis: immunophenotypic and cytogenetic findings in an infant. (10102017)
1999
33
DNA polymorphisms and mutations of the tumor necrosis factor-alpha (TNF-alpha) promoter in Langerhans cell histiocytosis (LCH). (9355965)
1997
34
Modulation of fibroblast activity in histiocytosis X by platelet-derived growth factor. (7874940)
1995
35
Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35. (1313990)
1992
36
Benign cephalic histiocytosis: a case report. (2400727)
1990
37
Malignant histiocytosis presenting as erythroderma. (2139870)
1990
38
Distribution of three proteinases in tumor cells of malignant histiocytosis]. (2279308)
1990
39
An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis. (2670186)
1989
40
Chronic myelomonocytic leukemia terminating as malignant histiocytosis. (3334348)
1987
41
Malignant histiocytosis complicating rheumatoid arthritis: report of four cases. (3950028)
1986
42
Chromosomal and fluorometric DNA analyses of malignant histiocytosis. (3811786)
1986
43
Histiocytosis X and erythropoietic protoporphyria. (6607997)
1984
44
Erythema annulare centrifugum and malignant histiocytosis--report of a case. (6499278)
1984
45
Malignant histiocytosis. Clinical and cytogenetic studies in a newborn and a child. (6883287)
1983
46
Non-B, non-T acute lymphoblastic leukaemia terminating in malignant histiocytosis: a new case and a review of the literature. (6293942)
1982
47
Ichthyosis and marrow involvement in malignant histiocytosis of the intestine. (7236527)
1981
48
Malignant histiocytosis in childhood: clinical study and therapeutic results in 22 cases. (7379013)
1980
49
Malignant histiocytosis in children from the Eastern Mediterranean. (7453672)
1980
50
Malignant histiocytosis associated with malabsorption. (262066)
1979

Variations for Histiocytosis

About this section

Expression for genes affiliated with Histiocytosis

About this section
Search GEO for disease gene expression data for Histiocytosis.

Pathways for genes affiliated with Histiocytosis

About this section

Pathways related to Histiocytosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CSF1, CSF1R
29.5CSF1R, CSF1
3
Show member pathways
9.5CSF1, CSF1R
49.5CSF1, CSF1R
59.2CD1A, CSF1, CSF1R
68.9CSF1, CSF1R, MYB

Compounds for genes affiliated with Histiocytosis

About this section

Compounds related to Histiocytosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1mdms449.8CSF1, S100B
2aclarubicin449.7MYB, CSF1
3filgrastim44 1110.7LIF, CSF1
4orcein449.6ACTC1, S100B
5mucicarmine449.5ACTC1, S100B
6ecori449.4MYB, S100B
7gm-csf44 2810.4CSF1, CSF1R, LIF
8bryostatin 1449.4CSF1, CSF1R
9adenine44 24 1111.4SLC29A3, MYB, S100B
10s 100449.4ACTC1, S100B, F13A1
11reticulin449.4ACTC1, F13A1, S100B
12b 723449.4S100B, ACTC1, F13A1
13sodium nitroprusside449.4CSF1, MYB, S100B
14hematoxylin449.4S100B, ACTC1, F13A1
151,25 dihydroxy vitamin d3449.3CSF1, LIF, CSF1R
16cytarabine44 50 1111.3CSF1R, LIF, CSF1
17methylcellulose449.3CSF1, MYB, LIF
18nitroblue tetrazolium449.2CSF1R, MYB, LIF
19phorbol449.2CSF1R, MYB, CSF1
20choline44 24 1111.2LIF, MYB, S100B
21agar449.1CSF1, LIF, CSF1R
22heparin44 28 24 1112.1F13A1, LIF, S100B, CSF1
23chloramphenicol44 1 50 1112.1S100B, MYB, CSF1
24dmso449.1CSF1, MYB, CSF1R
25wortmannin449.0LIF, CSF1, S100B, CSF1R
26thymidine44 249.8S100B, CSF1, MYB, LIF
27methionine448.8CSF1R, S100B, MYB, LIF
2812-o-tetradecanoylphorbol 13-acetate448.8MYB, LIF, CSF1R, CSF1
29iron44 249.7F13A1, ACTC1, S100B, MYB
30oligonucleotide448.7CSF1R, LIF, F13A1, MYB
31matrigel448.7LIF, CSF1, ACTC1
32glycogen44 249.7LIF, ACTC1, CSF1, S100B
33cycloheximide448.7CSF1, MYB, LIF, CSF1R
34creatinine448.6CSF1, S100B, LIF, ACTC1
35testosterone44 60 24 1111.5ACTC1, LIF, S100B, CSF1
36cyclosporin a44 28 6010.5ACTC1, S100B, LIF, MYB
37lipid448.3MYB, LIF, CSF1R, S100B, CD1A
38cysteine448.3CSF1, LIF, CSF1R, S100B, MYB
39arginine448.2S100B, MYB, LIF, CSF1
40imatinib44 50 1110.1ACTC1, S100B, CSF1, CSF1R, MYB
41serine448.0LIF, S100B, CSF1R, CSF1, MYB
42steroid448.0S100B, ACTC1, MYB, LIF, CSF1R
43paraffin447.9CSF1, ACTC1, CSF1R, S100B, F13A1, LIF
44calcium44 50 24 1110.8CD207, S100B, LIF, MYB, F13A1, ACTC1
45dexamethasone44 50 28 1110.6CSF1, CSF1R, MYB, S100B, LIF, ACTC1
46retinoic acid44 248.6MYB, LIF, ACTC1, CSF1, S100B, CSF1R
47tyrosine447.5LIF, S100B, CSF1, CSF1R, ACTC1, MYB
48progesterone44 28 60 24 1111.3F13A1, CSF1R, S100B, ACTC1, MYB, CSF1
49vegf447.3F13A1, LIF, MYB, ACTC1, CSF1R, CSF1
50estrogen447.3MYB, CSF1R, F13A1, S100B, CSF1, LIF

GO Terms for genes affiliated with Histiocytosis

About this section

Cellular components related to Histiocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.3S100B, CSF1, ACTC1, LIF

Biological processes related to Histiocytosis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage differentiationGO:00456519.6CSF1, LIF
2macrophage differentiationGO:00302259.6CSF1, CSF1R
3osteoclast differentiationGO:00303169.5CSF1R, CSF1
4hemopoiesisGO:00300979.5CSF1, CSF1R
5positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.3CSF1R, LIF
6cell proliferationGO:00082838.8S100B, CSF1, CSF1R
7positive regulation of cell proliferationGO:00082848.7S100B, CSF1, CSF1R, LIF

Sources for Histiocytosis

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet