MCID: HST011
MIFTS: 52

Histoplasmosis malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Histoplasmosis

Aliases & Descriptions for Histoplasmosis:

Name: Histoplasmosis 12 56 41 3 42 14 69
Infection by Histoplasma Capsulatum 69
Reticuloendotheliosis, X-Linked 42
Darling Disease 56

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1731
ICD10 33 B39 B39.9 B39.4
ICD9CM 35 115 115.9
Orphanet 56 ORPHA390
MESH via Orphanet 43 D006660
UMLS via Orphanet 70 C0019655 C0153261
ICD10 via Orphanet 34 B39.0 B39.1 B39.2 more

Summaries for Histoplasmosis

MedlinePlus : 41 histoplasmosis is a disease caused by a fungus (or mold) called histoplasma. the fungus is common in the eastern and central united states. it grows in soil and material contaminated with bat or bird droppings. you get infected by breathing the fungal spores. you cannot get the infection from someone else. histoplasmosis is often mild, with no symptoms. if you do get sick, it usually affects your lungs. symptoms include feeling ill, fever, chest pains, and a dry cough. in severe cases, histoplasmosis spreads to other organs. this is called disseminated disease. it is more common in infants, young children, seniors, and people with immune system problems. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. mild cases usually get better without treatment. treatment of severe or chronic cases is with antifungal drugs. centers for disease control and prevention

MalaCards based summary : Histoplasmosis, also known as infection by histoplasma capsulatum, is related to hepatitis and epididymo-orchitis, and has symptoms including nonproductive cough, headache and loss of appetite. An important gene associated with Histoplasmosis is ATP6V1A (ATPase H+ Transporting V1 Subunit A), and among its related pathways/superpathways are Influenza A and Allograft rejection. The drugs Bevacizumab and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and colon, and related phenotype is Increased shRNA abundance (Z-score > 2).

CDC : 3 Histoplasmosis is an infection caused by a fungus called Histoplasma. The fungus lives in the environment, particularly in soil that contains large amounts of bird or bat droppings. In the United States, Histoplasma mainly lives in the central and eastern states, especially areas around the Ohio and Mississippi River valleys. The fungus also lives in parts of Central and South America, Africa, Asia, and Australia.

Disease Ontology : 12 A primary systemic mycosis that results_in systemic fungal infection, has material basis in Histoplasma capsulatum var capsulatum or has material basis in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

Wikipedia : 71 Histoplasmosis (also known as \"Cave disease,\" \"Darling\'s disease,\" \"Ohio valley disease,\"... more...

Related Diseases for Histoplasmosis

Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
id Related Disease Score Top Affiliating Genes
1 hepatitis 29.7 HLA-A HLA-B HLA-DRB1 IFNG
2 epididymo-orchitis 29.5 HLA-A HLA-B
3 cryptococcosis 29.5 HLA-B HLA-DRB1
4 african histoplasmosis 12.2
5 american histoplasmosis 12.2
6 histoplasmosis pericarditis 12.0
7 histoplasmosis meningitis 11.8
8 histoplasmosis retinitis 11.8
9 blastomycosis 11.1
10 fibrosing mediastinitis 11.1
11 reticuloendotheliosis 10.9
12 rickets 10.8
13 chronic rhinitis 10.8
14 solid pseudopapillary carcinoma of pancreas 10.3 HLA-A HLA-B
15 myopathy, congenital nonprogressive, with moebius sequence and robin sequence 10.3 HLA-A HLA-B
16 tungiasis 10.3 ATP6V1A IFNG
17 immune deficiency, familial variable 10.2 HLA-B HLA-DRB1
18 mirizzi syndrome 10.2 HLA-B HLA-DRB1
19 aortic coarctation 10.2 HLA-A HLA-B
20 swine influenza 10.2 HLA-B HLA-DRB1
21 caplan's syndrome 10.2 HLA-DRB1 IFNG
22 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.2 HLA-B IFNG
23 distal trisomy 14q 10.2 HLA-DRB1 IFNG
24 bubonic plague 10.2 HLA-A HLA-B
25 cervical adenoid basal carcinoma 10.2 HLA-B HLA-DRB1
26 albinism 10.2 HLA-DRB1 IFNG
27 colorectal cancer, hereditary nonpolyposis, type 6 10.2 HLA-A HLA-B
28 cyclosporiasis 10.2 HLA-B IFNG
29 breast intraductal proliferative lesion 10.2 HLA-A TF
30 clostridium difficile colitis 10.2 HLA-DRB1 IFNG
31 myofibroma 10.2 HLA-DRB1 IFNG
32 orbital osteomyelitis 10.2 HLA-A HLA-B IFNG
33 autosomal recessive congenital methemoglobinemia 10.1 HLA-A HLA-B IFNG
34 pancreatic signet ring cell adenocarcinoma 10.1 HLA-DRB1 IFNG
35 disease of mental health 10.1 HLA-B HLA-DRB1 IFNG
36 gonococcal endophthalmia 10.1 HLA-A HLA-B
37 sacral nerve root cysts 10.1 HLA-A HLA-B HLA-DRB1
38 respiratory system disease 10.1 HLA-B HLA-DRB1 IFNG
39 hernia of ovary and fallopian tube 10.1 HLA-A HLA-B HLA-DRB1
40 learning disability 10.1 HLA-A HLA-B HLA-DRB1
41 choroiditis 10.1
42 nystagmus, congenital motor, autosomal recessive 10.1 HLA-A HLA-B HLA-DRB1
43 aseptic meningitis 10.1 HLA-A HLA-B HLA-DRB1
44 ciliary discoordination, due to random ciliary orientation 10.1 IFNG MICA
45 anaerobic meningitis 10.1 HLA-A HLA-B HLA-DRB1
46 folinic acid-responsive seizures 10.1 HLA-A HLA-B HLA-DRB1
47 parasitic helminthiasis infectious disease 10.1 HLA-A HLA-B HLA-DRB1
48 anterior corneal pigmentation 10.1 HLA-A HLA-B HLA-DRB1
49 acquired immunodeficiency syndrome 10.1
50 ectodermal dysplasia bartalos type 10.1 IFNG TF

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to Histoplasmosis

Symptoms & Phenotypes for Histoplasmosis

Symptoms:

12
  • nonproductive cough
  • headache
  • loss of appetite
  • muscle pains

UMLS symptoms related to Histoplasmosis:


fever, pruritus

GenomeRNAi Phenotypes related to Histoplasmosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.83 HLA-B HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.83 SLC17A5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.83 MICA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.83 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.83 SLC17A5
6 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.83 HLA-B HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.83 MICA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.83 SLC17A5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.83 SLC17A5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.83 SLC17A5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.83 HLA-A HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.83 HLA-A HLA-B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.83 MICA SLC17A5 HLA-A HLA-B
14 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.83 HLA-A HLA-B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.83 MICA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.83 SLC17A5
17 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.83 MICA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.83 HLA-B HLA-A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.83 HLA-B HLA-A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.83 SLC17A5
21 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.83 MICA

Drugs & Therapeutics for Histoplasmosis

Drugs for Histoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Phase 3 216974-75-3
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
3
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
4 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
5 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
6 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
9 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
11 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
13 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
14
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
15
Itraconazole Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 84625-61-6 55283
16
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
17
Fluconazole Approved Phase 3,Phase 2 86386-73-4 3365
18 Anti-Bacterial Agents Phase 3
19 Antibiotics, Antitubercular Phase 3
20 Antiparasitic Agents Phase 3
21 Antiprotozoal Agents Phase 3
22 Hydroxyitraconazole Phase 3,Phase 2,Phase 1,Early Phase 1
23 Liposomal amphotericin B Phase 3
24 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2
25 Pharmaceutical Solutions Phase 3,Early Phase 1
26
Ranibizumab Approved Phase 2,Phase 1 347396-82-1 459903
27
Verteporfin Approved, Investigational Phase 2 129497-78-5
28 Dermatologic Agents Phase 2
29 Photosensitizing Agents Phase 2
30
Ketoconazole Approved, Investigational Phase 1 65277-42-1 47576 3823
31
Petrolatum Approved Early Phase 1 8009-03-8
32 Anti-HIV Agents

Interventional clinical trials:

(show all 27)
id Name Status NCT ID Phase
1 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
2 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4
3 Macular Photocoagulation Study (MPS) Unknown status NCT00000158 Phase 3
4 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3
5 Submacular Surgery Trials (SST) Completed NCT00000150 Phase 3
6 A Multi-center Study of Spherule-Derived Coccidioidin Completed NCT00690092 Phase 3
7 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3
8 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3
9 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3
10 Treatment for Presumed Ocular Histoplasmosis Unknown status NCT01790893 Phase 1, Phase 2
11 Ranibizumab Versus PDT for Presumed Ocular Histoplasmosis Unknown status NCT00546936 Phase 2
12 Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization in Ocular Histoplasmosis Syndrome Unknown status NCT00955630 Phase 1, Phase 2
13 A Study of Itraconazole in the Treatment and Prevention of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000975 Phase 2
14 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2
15 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2
16 A Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000992 Phase 1
17 A Clinical Study to Evaluate the Pharmacokinetics of Lozanoc and Sporanox in Korean Healthy Male Volunteers Completed NCT02493738 Phase 1
18 Intravitreal Aflibercept Injection (IAI) for Presumed Ocular Histoplasmosis Syndrome Active, not recruiting NCT01578720 Phase 1
19 Withdrawal of Antifungal Treatment for Histoplasmosis in Patients After Improved Immune Response to Anti-HIV Drugs Completed NCT00006316
20 A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients Completed NCT00002438
21 Pilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00000627
22 A Comparison of HIV-Infected Patients With and Without Opportunistic (AIDS-Related) Infection Completed NCT00005572
23 Topical Itraconazole in the Treatment of Basal Cell Carcinoma Recruiting NCT02120677 Early Phase 1
24 Prevalence of Histoplasmosis in HIV + Patients With a Rapid Diagnostic Test in West Indies Active, not recruiting NCT01884779
25 Additive Benefit of the Urine LAM Test to Current TB Diagnostics in HIV Positive Adults in Panama City, Panama Not yet recruiting NCT02911740
26 Macugen for Histoplasmosis Terminated NCT00272766
27 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580

Search NIH Clinical Center for Histoplasmosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: histoplasmosis

Genetic Tests for Histoplasmosis

Anatomical Context for Histoplasmosis

MalaCards organs/tissues related to Histoplasmosis:

39
Lung, Testes, Colon, Skin, Bone, Bone Marrow, Kidney

Publications for Histoplasmosis

Articles related to Histoplasmosis:

(show top 50) (show all 758)
id Title Authors Year
1
Role of Transbronchial Needle Aspiration (Conventional and EBUS Guided) in the Diagnosis of Histoplasmosis in Patients Presenting with Mediastinal Lymphadenopathy. ( 28052172 )
2017
2
Acute Disseminated Histoplasmosis with Atypical Lymphocytosis in an Immunocompetent Host. ( 28070489 )
2017
3
Concomitant disseminated histoplasmosis and disseminated tuberculosis after tumor necrosis factor inhibitor treatment: a case report. ( 28086756 )
2017
4
Disseminated histoplasmosis presenting as diabetic keto-acidosis in an immunocompetent patient. ( 28062431 )
2017
5
Cytodiagnosis of disseminated histoplasmosis in an immunocompetent individual with molluscum contagiosum-like skin lesions and lymphadenopathy. ( 27756991 )
2016
6
Typical Facial Lesions: A Window of Suspicion for Progressive Disseminated Histoplasmosis-A Case of Asian Prototype. ( 27752372 )
2016
7
Clinical and Laboratory Profile of Persons Living with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome and Histoplasmosis from a Colombian Hospital. ( 27481056 )
2016
8
Childhood histoplasmosis in Colombia: Clinical and laboratory observations of 45 patients. ( 27118801 )
2016
9
Protease inhibitors and azolic antifungals in HIV patients with histoplasmosis: a clinical pharmacokinetics perspective. ( 27094235 )
2016
10
Primary cutaneous histoplasmosis in an immunocompromised patient with long-standing rheumatoid arthritis. ( 28001251 )
2016
11
Persistent nodal histoplasmosis in nuclear factor kappa B essential modulator deficiency: Report of a case and review of infection in primary immunodeficiencies. ( 27266944 )
2016
12
Pulmonary Histoplasmosis in a Japanese Man Infected During Travel to Mexico and Management of His Wife's Condition: A Case Report. ( 27032179 )
2016
13
Clinical Characteristics of Histoplasmosis in Siriraj Hospital. ( 27276735 )
2016
14
Tumiform Laryngeal Histoplasmosis. ( 27831533 )
2016
15
Disseminated histoplasmosis presenting as pelvic inflammatory disease. ( 26783441 )
2016
16
Sequential Chorioretinal Changes in Presumed Ocular Histoplasmosis Syndrome Analyzed Using Spectral Domain Optical Coherence Tomography. ( 27082105 )
2016
17
Hemophagocytic Lymphohistiocytosis and Progressive Disseminated Histoplasmosis. ( 27191972 )
2016
18
Unusual presentation of disseminated histoplasmosis. ( 27817934 )
2016
19
Bilateral adrenal histoplasmosis in an immunocompetent man from Texas. ( 27995051 )
2016
20
Disseminated Histoplasmosis: A Fatal Opportunistic Infection in Disguise. ( 27365926 )
2016
21
Disseminated Histoplasmosis: A Challenging Differential Diagnostic Consideration for Suspected Malignant Lesions in the Digestive Tract. ( 27920657 )
2016
22
Adrenal Histoplasmosis in Immunocompetent Patients Presenting as Adrenal Insufficiency. ( 27136109 )
2016
23
Hemophagocytic lymphohistiocytosis secondary to iatrogenic disseminated histoplasmosis. ( 28092891 )
2016
24
Progressive Disseminated Histoplasmosis with Coomb's Positive Hemolytic Anemia in an Immunocompetent Host. ( 27759351 )
2016
25
Histoplasmosis-Induced Hemophagocytic Lymphohistiocytosis in an Adult Patient: A Case Report and Review of the Literature. ( 27830097 )
2016
26
RYP1 gene as a target for molecular diagnosis of histoplasmosis. ( 27633713 )
2016
27
Intestinal histoplasmosis in immunocompetent adults. ( 27099446 )
2016
28
Primary Cutaneous Histoplasmosis in an Immunocompetent Host from a Nonendemic Area. ( 27512207 )
2016
29
Bilateral adrenal masses in a diabetic patient: An unusual presentation of histoplasmosis. ( 27772945 )
2016
30
Laryngeal histoplasmosis. ( 27535733 )
2016
31
Disseminated Histoplasmosis with Haemophagocytic Lymphohistiocytosis in an Immunocompetent Host. ( 27134914 )
2016
32
Treatment of CNV secondary to presumed ocular histoplasmosis with intravitreal aflibercept 2.0 mg injection. ( 27085265 )
2016
33
The Simultaneous Occurrence of Histoplasmosis and Cryptococcal Fungemia: A Case Report and Review of the Literature. ( 27423433 )
2016
34
Cutaneous histoplasmosis with prominent parasitization of epidermal keratinocytes: report of a case. ( 27516534 )
2016
35
Primary cutaneous histoplasmosis mimicking basal cell carcinoma of the eyelid: A case report and review of literature. ( 27166049 )
2016
36
PS01.17: Community-Based Low-Dose Computed Tomography (LDCT) Lung Cancer Screening in the US Histoplasmosis Belt: One Year Followup: Topic: Pulmonology. ( 27969485 )
2016
37
A Rare Case of Juvenile Systemic Lupus Erythematosus with Disseminated Histoplasmosis. ( 27904204 )
2016
38
Importance of multidisciplinary approach in diagnosis of histoplasmosis. ( 27438207 )
2016
39
Histoplasmosis mimicking non-Hodgkin lymphoma in a 40-year-old man with AIDS. ( 27535728 )
2016
40
Scleritis Due to Histoplasmosis. ( 26764883 )
2016
41
Histoplasmosis. ( 26897068 )
2016
42
Antigen Concentrations as an Indicator of Clinical Remission and Disease Relapse in Cats with Histoplasmosis. ( 27158815 )
2016
43
Subacute progressive disseminated histoplasmosis in immunocompetent patient. ( 26898594 )
2016
44
Disseminated histoplasmosis demonstrated on F18-fluorodeoxyglucose positron emission tomography/computed tomography in a renal transplant recipient. ( 27095874 )
2016
45
Spatial distribution of disseminated histoplasmosis and AIDS co-infection in an endemic area of Northeastern Brazil. ( 27192593 )
2016
46
Chronic meningitis, hydrocephalus and spinal paraplegia in non-systemic histoplasmosis. ( 27338647 )
2016
47
Histoplasma capsulatum sinusitis: Possible way of revelation to the disseminated form of histoplasmosis in HIV patients: Case report and literature review. ( 27227446 )
2016
48
Cutaneous presentation of disseminated histoplasmosis as a solitary peri-anal ulcer. Case report and discussion. ( 26969605 )
2016
49
Presentation and Treatment of Histoplasmosis in Pediatric Oncology Patients: Case Series and Review of the Literature. ( 27258034 )
2016
50
Correction: Chronic Pulmonary Histoplasmosis and its Clinical Significance: an Under-reported Systemic Fungal Disease. ( 27990324 )
2016

Variations for Histoplasmosis

Expression for Histoplasmosis

Search GEO for disease gene expression data for Histoplasmosis.

Pathways for Histoplasmosis

Pathways related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 HLA-A HLA-B HLA-DRB1 IFNG
2
Show member pathways
12.29 HLA-A HLA-B HLA-DRB1 IFNG MICA
3
Show member pathways
12.16 HLA-A HLA-B HLA-DRB1 IFNG
4 12.14 HLA-A HLA-B HLA-DRB1
5
Show member pathways
12.04 HLA-A HLA-B IFNG MICA
6
Show member pathways
11.82 HLA-A HLA-B IFNG
7 11.81 HLA-A HLA-B HLA-DRB1
8 11.76 HLA-A HLA-B MICA
9
Show member pathways
11.63 HLA-A HLA-DRB1 IFNG
10 11.56 HLA-A HLA-B HLA-DRB1 IFNG
11 11.45 ATP6V1A HLA-DRB1 IFNG
12 11.12 HLA-B IFNG
13 11.11 ATP6V1A HLA-A HLA-B HLA-DRB1
14 11.01 HLA-DRB1 IFNG
15 10.97 HLA-DRB1 IFNG
16 10.91 HLA-A HLA-B

GO Terms for Histoplasmosis

Cellular components related to Histoplasmosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 HLA-A HLA-B HLA-DRB1 MICA TF
2 MHC class I protein complex GO:0042612 9.26 HLA-A HLA-B
3 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-A HLA-B HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-A HLA-B HLA-DRB1

Biological processes related to Histoplasmosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 HLA-A HLA-B HLA-DRB1 IFNG
2 retina homeostasis GO:0001895 9.46 ARMS2 TF
3 regulation of immune response GO:0050776 9.46 HLA-A HLA-B IFNG MICA
4 transferrin transport GO:0033572 9.43 ATP6V1A TF
5 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.4 HLA-A HLA-B
6 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.32 HLA-A HLA-B
7 protection from natural killer cell mediated cytotoxicity GO:0042270 9.26 HLA-A HLA-B
8 interferon-gamma-mediated signaling pathway GO:0060333 9.26 HLA-A HLA-B HLA-DRB1 IFNG
9 antigen processing and presentation GO:0019882 9.02 HLA-A HLA-B HLA-DRB1 IFNG MICA

Molecular functions related to Histoplasmosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 beta-2-microglobulin binding GO:0030881 8.96 HLA-A MICA
2 peptide antigen binding GO:0042605 8.8 HLA-A HLA-B HLA-DRB1

Sources for Histoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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