MCID: HST011
MIFTS: 73

Histoplasmosis malady

Rare diseases, Infectious diseases categories

Summaries for Histoplasmosis

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Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Histoplasmosis is a disease caused by a fungus (or mold) called histoplasma. the fungus is common in the eastern and central united states. it grows in soil and material contaminated with bat or bird droppings. you get infected by breathing the fungal spores. you cannot get the infection from someone else. histoplasmosis is often mild, with no symptoms. if you do get sick, it usually affects your lungs. symptoms include feeling ill, fever, chest pains, and a dry cough. in severe cases, histoplasmosis spreads to other organs. this is called disseminated disease. it is more common in infants, young children, seniors, and people with immune system problems. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. mild cases usually get better without treatment. treatment of severe or chronic cases is with antifungal drugs. centers for disease control and prevention

MalaCards: Histoplasmosis, also known as reticuloendotheliosis, is related to cryptococcosis and tuberculosis, and has symptoms including muscle pains, loss of appetite and headache. An important gene associated with Histoplasmosis is MICA (MHC class I polypeptide-related sequence A), and among its related pathways are Primary immunodeficiency and TCR signaling. The drugs ketoconazole and itraconazole and the compounds pneumococcal and hemocyanin have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and colon, and related mouse phenotypes are no phenotypic analysis and integument.

Disease Ontology:9 A primary systemic mycosis that results in systemic fungal infection, has material basis in histoplasma capsulatum var capsulatum or has material basis in histoplasma capsulatum var duboisii, transmitted by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

CDC:4 Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum.  The fungus lives in the environment, usually in association with large amounts of bird or bat droppings. Lung infection can occur after a person inhales airborne, microscopic fungal spores from the environment; however, many people who inhale the spores do not get sick. The symptoms of histoplasmosis are similar to pneumonia, and the infection can sometimes become serious if it is not treated.

Wikipedia:66 Histoplasmosis (also known as \"Cave disease,\" \"Darling\'s disease,\" \"Ohio valley disease,\"... more...

Aliases & Classifications for Histoplasmosis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 35MedlinePlus, 63UMLS, 36MeSH, 59SNOMED-CT, 28ICD9CM, 41NCIt, 27ICD10 via Orphanet, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Aliases & Descriptions:

histoplasmosis 9 11 50 35 63
reticuloendotheliosis 9 44 46
reticuloendotheliosis, x-linked 44 63
infection by histoplasma capsulatum 63
reticuloendothelial hyperplasia 9
darling disease 50


External Ids:

Disease Ontology9 DOID:1731
MeSH36 D006660
ICD9CM28 115.9, 115
NCIt41 C77201
ICD10 via Orphanet27 B39.0, B39.2, B39.3 B39.4, B39.1, B39.5, B39.9, more
MESH via Orphanet37 D006660
SNOMED-CT via Orphanet60 12962009, 76255006
UMLS via Orphanet64 C0019655, C0153261
ICD1026 B39, B39.4, B39.9

Related Diseases for Histoplasmosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 250)
idRelated DiseaseScoreTop Affiliating Genes
1cryptococcosis30.3CD4
2tuberculosis30.3HLA-A, HLA-DRB1, TNF, STAT1, IFNG, ACPP
3syphilis30.3CD4, CD79A
4candidiasis30.3IFNG, CD4, CD79A
5meningitis30.2HLA-B, CD4, CD79A
6vasculitis30.2CD40LG, CD79A, TNF, HLA-B
7nephritis30.2ACE, CD79A, CD40LG
8leprosy30.1CD4, HLA-DRB1
9toxoplasmosis30.1CD40LG, CD79A, CD4
10hepatitis30.1HLA-B, HLA-A, STAT1, CD4, CD40LG, SLC17A5
11eosinophilia30.0STAT1, IFNG, CD4, CD79A
12inflammatory bowel disease30.0IFNG, STAT1, TNF, HLA-B
13protein-losing enteropathy29.9TF
14prostatitis29.9ACPP, CD79A
15rheumatoid arthritis29.9HLA-A, HLA-DRB1, TNF, STAT1, IFNG, CD4
16arthritis29.9HLA-B, HLA-A, HLA-DRB1, TNF, STAT1, IFNG
17sarcoidosis29.9HLA-A, HLA-DRB1, TNF, STAT1, IFNG, ACE
18pneumonia29.9TNF, CD4, CD79A
19systemic lupus erythematosus29.8HLA-A, HLA-DQA1, HLA-DRB1, TNF, STAT1, IFNG
20burkitt's lymphoma29.7HLA-B, HLA-DRB1, STAT1, ACPP, CD4, CD79A
21connective tissue disease29.7HLA-A, HLA-DRB1, TNF, CD4, CD79A, CD40LG
22hepatitis c29.6TF, HLA-A, HLA-DRB1, STAT1, IFNG, CD4
23uveitis29.6HLA-B, HLA-A, TNF, IFNG, ACE, CD4
24leukemia29.4HLA-B, HLA-A, HLA-DRB1, TNF, STAT1, IFNG
25african histoplasmosis10.7
26acquired immunodeficiency syndrome10.5
27choroiditis10.5
28blastomycosis10.5
29coccidioidomycosis10.4
30intrapelvic lymph node leukemic reticuloendotheliosis10.4
31lymphangitis10.3
32paracoccidioidomycosis10.3
33laryngitis10.3
34mediastinitis10.3
35histoplasmosis pericarditis10.2
36penicilliosis10.2
37multifocal choroiditis10.2
38american histoplasmosis10.2
39hypercalcemia10.2
40addison's disease10.2
41histoplasmosis retinitis10.2
42histoplasmosis meningitis10.2
43hairy cell leukemia of spleen10.2
44hairy cell leukemia10.2
45fascioliasis10.1SLC17A5
46hemorrhagic fever10.1CD40LG
47dysentery10.1CD79A
48q fever10.1CD79A
49schnitzler syndrome10.1CD40LG
50macroglobulinemia10.1CD79A

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to histoplasmosis

Symptoms for Histoplasmosis

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9Disease Ontology
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Symptoms:

9
  • muscle pains
  • loss of appetite
  • headache
  • nonproductive cough

Drugs & Therapeutics for Histoplasmosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Histoplasmosis

Drug clinical trials:

Search ClinicalTrials for Histoplasmosis

Search NIH Clinical Center for Histoplasmosis

Search CenterWatch for Histoplasmosis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Histoplasmosis

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Anatomical Context for Histoplasmosis

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34MalaCards
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MalaCards organs/tissues related to Histoplasmosis:

34
Lung, Testes, Colon, Skin, Bone, Bone marrow, Kidney, T cells, B cells, Tongue, Lymph node, Retina, Endothelial, Myeloid, Prostate, Whole blood, Adrenal gland, Liver, Spleen, Brain, Heart, Spinal cord

Animal Models for Histoplasmosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Histoplasmosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1HLA-B, TNF, STAT1, IFNG, CD4, CD79A
2MP:00107717.8TNF, STAT1, IFNG, ACPP, CD4, CD40LG
3MP:00036317.4HLA-B, TNF, STAT1, IFNG, CD4, CD79A
4MP:00053847.2TNF, STAT1, IFNG, ACE, CD4, CD79A
5MP:00053766.9TF, TNF, STAT1, IFNG, ACE, CD4
6MP:00053786.8TNF, STAT1, IFNG, ACE, CD4, EGF
7MP:00053976.7CD40LG, TF, HLA-B, HLA-DQA1, TNF, STAT1
8MP:00053876.6HLA-B, HLA-DQA1, TNF, STAT1, IFNG, ACE
9MP:00107686.4TF, HLA-B, TNF, STAT1, IFNG, ACE

Publications for Histoplasmosis

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Sources:
53PubMed
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Articles related to Histoplasmosis:

(show top 50)    (show all 623)
idTitleAuthorsYear
1
Histoplasmosis in a state where it is not known to be endemic-montana, 2012-2013. (24354878)
2014
2
Application of nested PCR for diagnosis of histoplasmosis. (23345048)
2013
3
Adrenal hypofunction from histoplasmosis: a literature review from 1971 to 2012. (23771479)
2013
4
Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis. (23541320)
2013
5
Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia. (23467543)
2013
6
Unusual presentations of disseminated histoplasmosis. (22715652)
2012
7
Disseminated cutaneous histoplasmosis in an immunocompetent adult. (22707773)
2012
8
Disseminated histoplasmosis and haemophagocytic syndrome in two kidney transplant patients. (23013962)
2012
9
Histoplasmosis infection in patients with rheumatoid arthritis, 1998-2009. (21605439)
2011
10
Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. (21911464)
2011
11
Adrenal histoplasmosis: An unusual cause of adrenomegaly. (22022092)
2011
12
Pulmonary histoplasmosis. (22167401)
2011
13
Bilateral adrenal histoplasmosis: endoscopic ultrasound-guided fine needle aspiration as a method of diagnosis and assessment. (22390113)
2011
14
Clinical and evolutionary characteristics of four patients with pulmonary histoplasmosis reported in the ParaA-ba Paulista Valley region. (21085880)
2010
15
Disseminated histoplasmosis presenting with chronic ulcerative tongue lesions in a patient with diabetes. (22791841)
2010
16
Histoplasmosis in the nasal septum without pulmonary involvement in a patient with acquired immunodeficiency syndrome: case report and literature review. (21120437)
2010
17
Imported histoplasmosis: two distinct profiles in travelers and immigrants. (19674266)
2009
18
Disseminated histoplasmosis presenting as granulomatous epididymo-orchitis. (19745612)
2009
19
Disseminated histoplasmosis by Histoplasma capsulatum var. duboisii in a paediatric patient from the Chad Republic, Africa. (19005708)
2009
20
Case report: Esophageal histoplasmosis associated with disseminated tuberculosis in acquired immunodeficiency syndrome. (19270280)
2009
21
Histoplasmosis in children. (19879506)
2009
22
First case report of histoplasmosis in a cat in Japan. (20046039)
2009
23
Oral histoplasmosis: an unusual presentation. (18798316)
2009
24
Education and imaging. Gastrointestinal: Gastrointestinal histoplasmosis. (18397490)
2008
25
Outbreak of histoplasmosis among travelers returning from El Salvador--Pennsylvania and Virginia, 2008. (19092757)
2008
26
Images in emergency medicine. Erythema nodosum associated with pulmonary histoplasmosis. (19027494)
2008
27
Mediastinal lymphatic drainage from pulmonary lobe based on CT observations of histoplasmosis: implications for minimal N2 disease of non-small-cell lung cancer. (17952543)
2007
28
Disseminated histoplasmosis and tuberculosis in a patient with HIV infection. (17594164)
2007
29
Platelia Aspergillus assay for diagnosis of disseminated histoplasmosis. (17874253)
2007
30
Laryngeal histoplasmosis as a mimicker of squamous cell carcinoma: imaging and histologic findings. (18225621)
2007
31
Tumor necrosis factor-alpha antagonism by the murine tumor necrosis factor-alpha receptor 2-Fc fusion protein exacerbates histoplasmosis in mice. (17572011)
2007
32
Penoscrotal histoplasmosis following bladder carcinoma. (17593111)
2007
33
Histoplasmosis-associated cross-reactivity in the BioRad Platelia Aspergillus enzyme immunoassay. (17344352)
2007
34
Molecular epidemiology of canine histoplasmosis in Japan. (17464845)
2007
35
Disseminated histoplasmosis mimicking laryngeal carcinoma from central India--a case report. (17001921)
2006
36
Disseminated histoplasmosis presenting as thrombotic microangiopathy. (16836570)
2006
37
Gastric histoplasmosis. (16377536)
2006
38
Cases of histoplasmosis reported in Taiwan. (16877229)
2006
39
Preventing reactivation of ocular histoplasmosis: guidance for patients at risk. (16458241)
2006
40
Association of the HLA-DR15/HLA-DQ6 haplotype with development of choroidal neovascular lesions in presumed ocular histoplasmosis syndrome. (14522093)
2003
41
Histoplasmosis-like choroiditis in a nonendemic area: the northwest United States. (9654410)
1998
42
African histoplasmosis: osteomyelitis of the radius. (9670760)
1998
43
African histoplasmosis: a review. (15538817)
1997
44
Focal lesion of African histoplasmosis presenting as a malignant gastric ulcer. (8799429)
1996
45
African histoplasmosis masquerading as carcinoma of the colon. Report of a case and review of literature. (2676427)
1989
46
Mandibular African histoplasmosis: imitation of neoplasia or giant-cell granuloma? (3422400)
1988
47
Multifocal choroiditis and panuveitis. A syndrome that mimics ocular histoplasmosis. (6508619)
1984
48
Maxillary African histoplasmosis mimicking malignant jaw tumour. (285725)
1979
49
EXPERIMENTAL OCULAR HISTOPLASMOSIS. VI. FLUORESCEIN FUNDUS PHOTOGRAPHS OF CHOROIDITIS IN THE PRIMATE. (14233705)
1964
50
African histoplasmosis of the lungs with diffuse suppuration appearing after a year's development]. (13654699)
1959

Variations for Histoplasmosis

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Expression for genes affiliated with Histoplasmosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Histoplasmosis

Search GEO for disease gene expression data for Histoplasmosis.

Pathways for genes affiliated with Histoplasmosis

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Sources:
51PathCards, 31KEGG, 56Reactome, 54QIAGEN, 61Thomson Reuters, 39NCBI BioSystems Database, 55R&D Systems, 58SinoBiological
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Pathways related to Histoplasmosis according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CD40LG, CD79A, CD4
2
Show member pathways
9.6CD4, HLA-DRB1, HLA-DQA1
3
Show member pathways
9.6HLA-DRB1, CD4, HLA-DQA1
4
Show member pathways
9.6HLA-DRB1, HLA-DQA1, CD4
5
Show member pathways
9.6HLA-A, HLA-B, STAT1
69.5HLA-DRB1, CD4, STAT1
79.5CD40LG, HLA-A, HLA-B
8
Show member pathways
TCR signaling in naive CD8+ T cells39
9.5CD4, HLA-DRB1, HLA-A
9
Show member pathways
9.4CD4, IFNG, STAT1
109.4HLA-B, STAT1, IFNG
11
Show member pathways
Immune response T cell receptor signaling pathway61
Immune response CD28 signaling61
Immune response ICOS pathway in T helper cell61
9.4CD79A, HLA-DRB1, CD4, HLA-DQA1
12
Show member pathways
9.3HLA-DRB1, CD4, STAT1, HLA-DQA1
139.3IFNG, CD4, HLA-DRB1
14
Show member pathways
9.2HLA-DRB1, HLA-A, HLA-DQA1, HLA-B
159.1TF, IFNG, EGF
169.0HLA-DRB1, TNF, CD4
17
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.9IFNG, TNF, STAT1
18
Show member pathways
Immune response MIF in innate immunity response61
8.9STAT1, IFNG, TNF
19
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
8.9HLA-DRB1, EGF, HLA-DQA1, CD4, STAT1
208.8IFNG, CD40LG, TNF
21
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.8CD40LG, IFNG, TNF
22
Show member pathways
8.8TNF, CD40LG, HLA-A, HLA-DQA1
23
Show member pathways
Ras signaling in the CD4+ TCR pathway39
8.8IFNG, HLA-A, TNF
248.7HLA-B, ATP6V1A, HLA-A, HLA-DQA1, HLA-DRB1
25
Show member pathways
Immune response IL 12 induced IFN gamma production61
8.7HLA-A, HLA-DRB1, STAT1, IFNG, CD4
26
Show member pathways
8.6HLA-DQA1, CD4, CD79A, STAT1, EGF, HLA-DRB1
278.6HLA-DQA1, CD4, CD40LG, HLA-A, HLA-B, HLA-DRB1
28
Show member pathways
IL27-mediated signaling events39
8.6IFNG, STAT1, TNF, CD4
29
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.6CD4, IFNG, STAT1, TNF
308.5IFNG, TNF, HLA-DRB1, CD4
31
Show member pathways
8.4HLA-DQA1, HLA-B, HLA-A, IFNG, HLA-DRB1, STAT1
328.4TNF, EGF, IFNG, STAT1
338.4STAT1, TNF, IFNG, EGF
348.4IFNG, HLA-DRB1, HLA-B, HLA-A, POLR3B, HLA-DQA1
358.4HLA-DRB1, TNF, HLA-DQA1, HLA-A, HLA-B
36
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.3TNF, IFNG, CD4, CD40LG, CD79A
378.3IFNG, STAT1, HLA-DRB1, TNF, HLA-DQA1
38
Show member pathways
Immune response CD16 signaling in NK cells61
8.3IFNG, HLA-B, HLA-A, TNF, MICA
39
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.3TNF, IFNG, STAT1, ACE
40
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
8.2IFNG, CD4, HLA-B, HLA-A, TNF
41
Show member pathways
8.1EGF, STAT1, TNF, CD4, IFNG
42
Show member pathways
8.1STAT1, IFNG, CD4, EGF, TNF
43
Show member pathways
8.1CD40LG, TNF, EGF, CD4, IFNG
448.0HLA-DQA1, HLA-DRB1, TNF, IFNG, ATP6V1A
45
Show member pathways
8.0HLA-DRB1, STAT1, CD40LG, IFNG, HLA-DQA1, TNF
46
Show member pathways
8.0CD40LG, HLA-DQA1, POLR3B, TNF, HLA-DRB1, IFNG
47
Show member pathways
7.9CD79A, CD4, HLA-B, EGF, HLA-DRB1, HLA-DQA1
48
Show member pathways
7.6HLA-DRB1, HLA-DQA1, STAT1, IFNG, HLA-B, HLA-A
49
Show member pathways
7.6HLA-DRB1, HLA-DQA1, TNF, STAT1, IFNG, CD79A
50
Show member pathways
7.1IFNG, TNF, CD40LG, CD4, MICA, HLA-DRB1

Compounds for genes affiliated with Histoplasmosis

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Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 12DrugBank, 25HMDB, 3BitterDB, 62Tocris Bioscience
See all sources

Compounds related to Histoplasmosis according to GeneCards/GeneDecks:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1pneumococcal469.8HLA-B, CD79A, CD40LG, SLC17A5
2hemocyanin469.8CD79A, CD40LG, CD4
3phenytoin46 52 30 1212.7CD79A, HLA-B, SLC17A5, CD40LG
4gliadin469.7CD79A, STAT1, CD40LG
5tuberculin469.7CD40LG, CD79A, IFNG
6ursodeoxycholic acid46 25 1211.7HLA-B, SLC17A5, CD40LG, HLA-A
7gamma globulin469.6SLC17A5, IFNG, CD40LG, CD79A
8vitamin b12469.6TF, CD79A, SLC17A5, CD40LG
9antipyrine46 1210.5SLC17A5, HLA-B, TF
10polyethylene glycol469.5TF, CD40LG, CD79A, SLC17A5
11blys469.4TNF, CD79A, CD40LG
12allergens469.4CD40LG, CD79A, IFNG, HLA-DRB1
13agar469.2TF, EGF, CD40LG, CD79A, ACPP
14paraffin469.2HLA-DQA1, HLA-B, CD40LG, CD79A, TF, ACPP
15phosphotyrosine469.2ACPP, HLA-B, STAT1, EGF, CD4
16lapatinib46 52 1211.1HLA-DRB1, HLA-DQA1, EGF
17aspartate469.0TF, HLA-DQA1, ACPP, CD40LG, SLC17A5, HLA-B
18okt3469.0CD40LG, CD79A, TNF, IFNG
19polysaccharide469.0CD40LG, CD79A, CD4, HLA-B, TF
20gold sodium thiomalate469.0HLA-DRB1, TNF, IFNG
21mycophenolate mofetil46 52 1211.0CD79A, CD40LG, IFNG, TNF
22ivig469.0IFNG, CD79A, TNF, CD40LG
23carbamazepine46 52 1211.0SLC17A5, TNF, CD79A, HLA-B, HLA-A
24polyinosinic-polycytidylic acid468.9HLA-B, IFNG, TNF, STAT1
252,5-oligoadenylate468.9IFNG, HLA-B, STAT1, TNF
26chloroquine46 3 52 30 1212.9CD79A, TF, TNF, CD4
27ribavirin46 52 1210.9SLC17A5, TF, HLA-B, STAT1, IFNG, CD40LG
28oligonucleotide468.8HLA-B, HLA-A, HLA-DRB1, STAT1, ACPP, HLA-DQA1
29methotrexate52 46 1210.7CD79A, SLC17A5, HLA-DRB1, TNF, TF
30prednisolone46 30 1210.7CD79A, TF, IFNG, SLC17A5, TNF
31n acetylcysteine468.7CD79A, TF, TNF, STAT1, SLC17A5, CD40LG
32creatinine468.6ACE, ACPP, CD40LG, TF, SLC17A5, CD79A
33fibrinogen468.6HLA-B, TF, CD79A, TNF, CD40LG, SLC17A5
34alanine468.5HLA-DRB1, TF, SLC17A5, CD40LG, CD79A, ACPP
35cholesterol46 30 25 1211.5HLA-B, TF, ACPP, ACE, STAT1, SLC17A5
36endotoxin468.5HLA-B, TNF, CD40LG, STAT1, IFNG, SLC17A5
37rantes468.4CD4, IFNG, STAT1, TNF, CD40LG, HLA-B
38lactate468.4SLC17A5, ACPP, CD40LG, TF, TNF, HLA-B
39neopterin468.3TNF, ACPP, CD4, CD79A, CD40LG, SLC17A5
40indomethacin46 30 62 1211.3TNF, STAT1, CD79A, IFNG, CD40LG, EGF
41herbimycin a46 629.3STAT1, TNF, EGF, CD40LG, CD4, IFNG
42genistein46 30 62 3 25 1213.2TNF, IFNG, CD4, STAT1, CD40LG, EGF
43arginine468.2ACPP, IFNG, STAT1, HLA-DRB1, CD40LG, CD79A
44h2o2468.1SLC17A5, EGF, STAT1, TNF, CD79A, HLA-B
45tacrolimus46 52 1210.0TNF, IFNG, TF, HLA-B, CD79A, SLC17A5
46dexamethasone46 52 30 1210.9CD79A, IFNG, HLA-B, EGF, CD40LG, TNF
47vegf467.7EGF, CD40LG, TNF, STAT1, CD79A, ACPP
48retinoic acid46 258.7CD79A, IFNG, TNF, HLA-B, EGF, CD40LG
49cyclosporin a46 30 629.5STAT1, SLC17A5, CD40LG, CD79A, IFNG, TF
50pge2467.3TNF, TF, HLA-B, CD40LG, CD79A, CD4

GO Terms for genes affiliated with Histoplasmosis

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Sources:
17Gene Ontology
See all sources

Cellular components related to Histoplasmosis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1multivesicular bodyGO:0057719.9CD79A, ACPP
2MHC class I protein complexGO:0426129.9HLA-A, HLA-B
3MHC class II protein complexGO:0426139.9HLA-DQA1, HLA-DRB1
4integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.4HLA-B, HLA-A, HLA-DQA1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:0125079.4HLA-B, HLA-A, HLA-DQA1, HLA-DRB1
6Golgi membraneGO:0001399.2HLA-DRB1, HLA-DQA1, HLA-A, HLA-B
7membrane raftGO:0451218.8TNF, CD4, CD79A
8lysosomal membraneGO:0057658.7ATP6V1A, HLA-DQA1, HLA-DRB1, ACPP, EGF, SLC17A5
9cell surfaceGO:0099868.5TF, HLA-B, HLA-A, TNF, MICA
10external side of plasma membraneGO:0098977.6CD40LG, HLA-DRB1, TNF, IFNG, ACE, CD4
11integral component of plasma membraneGO:0058877.4ATP6V1A, HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, TNF
12extracellular vesicular exosomeGO:0700627.4TF, ATP6V1A, HLA-B, HLA-A, HLA-DRB1, ACPP
13extracellular spaceGO:0056157.1TF, TNF, MICA, IFNG, ACPP, ACE
14plasma membraneGO:0058865.8ATP6V1A, HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, TNF

Biological processes related to Histoplasmosis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:00248610.1HLA-A, HLA-B
2negative regulation of metanephric nephron tubule epithelial cell differentiationGO:07230810.0IFNG, STAT1
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00248010.0HLA-A, HLA-B
4negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:00334010.0IFNG, STAT1
5type I interferon signaling pathwayGO:0603379.8HLA-B, HLA-A, STAT1
6T cell costimulationGO:0312959.8CD4, HLA-DRB1, HLA-DQA1
7detection of bacteriumGO:0160459.8HLA-DRB1, HLA-A, HLA-B
8T cell receptor signaling pathwayGO:0508529.7HLA-DQA1, HLA-DRB1, CD4
9regulation of interferon-gamma-mediated signaling pathwayGO:0603349.7STAT1, IFNG
10regulation of immune responseGO:0507769.7CD40LG, HLA-A, HLA-B
11regulation of immunoglobulin secretionGO:0510239.7TNF, CD40LG
12defense response to virusGO:0516079.6POLR3B, STAT1, MICA, IFNG
13positive regulation of T cell mediated cytotoxicityGO:0019169.5HLA-A, HLA-B
14positive regulation of vitamin D biosynthetic processGO:0605579.5IFNG, TNF
15positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4IFNG, TNF
16positive regulation of chemokine biosynthetic processGO:0450809.4IFNG, TNF
17viral processGO:0160329.3CD4, MICA, STAT1, HLA-A, HLA-B
18immune responseGO:0069559.2HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, CD4
19positive regulation of membrane protein ectodomain proteolysisGO:0510449.2IFNG, TNF
20negative regulation of growth of symbiont in hostGO:0441309.2IFNG, TNF
21protein import into nucleus, translocationGO:0000609.1IFNG, TNF
22positive regulation of osteoclast differentiationGO:0456729.0IFNG, TNF
23interferon-gamma-mediated signaling pathwayGO:0603338.8IFNG, STAT1, HLA-DRB1, HLA-DQA1, HLA-A, HLA-B
24cytokine-mediated signaling pathwayGO:0192218.8HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, STAT1, IFNG

Molecular functions related to Histoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP bindingGO:0469779.7HLA-B, HLA-A
2MHC class II receptor activityGO:0323959.6HLA-DRB1, HLA-DQA1
3peptide antigen bindingGO:0426059.4HLA-DRB1, HLA-A, HLA-B
4tumor necrosis factor receptor bindingGO:0051649.2CD40LG, STAT1, TNF
5cytokine activityGO:0051258.8CD40LG, IFNG, TNF

Products for genes affiliated with Histoplasmosis

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Sources for Histoplasmosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet