MCID: HST011
MIFTS: 64

Histoplasmosis malady

Rare diseases, Infectious diseases categories

Summaries for Histoplasmosis

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MedlinePlus:32 Histoplasmosis is a disease caused by a fungus (or mold) called histoplasma. the fungus is common in the eastern and central united states. it grows in soil and material contaminated with bat or bird droppings. you get infected by breathing the fungal spores. you cannot get the infection from someone else. histoplasmosis is often mild, with no symptoms. if you do get sick, it usually affects your lungs. symptoms include feeling ill, fever, chest pains, and a dry cough. in severe cases, histoplasmosis spreads to other organs. this is called disseminated disease. it is more common in infants, young children, seniors, and people with immune system problems. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. mild cases usually get better without treatment. treatment of severe or chronic cases is with antifungal drugs. centers for disease control and prevention

MalaCards based summary: Histoplasmosis, also known as reticuloendotheliosis, is related to cryptococcosis and syphilis, and has symptoms including nonproductive cough, headache and loss of appetite. An important gene associated with Histoplasmosis is MICA (MHC class I polypeptide-related sequence A), and among its related pathways are Primary immunodeficiency and Translocation of ZAP-70 to Immunological synapse. The drugs itraconazole and ketoconazole and the compounds pneumococcal and hemocyanin have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and colon, and related mouse phenotypes are no phenotypic analysis and integument.

Disease Ontology:9 A primary systemic mycosis that results in systemic fungal infection, has material basis in histoplasma capsulatum var capsulatum or has material basis in histoplasma capsulatum var duboisii, transmitted by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

CDC:3 Histoplasmosis is an infection caused by a fungus called Histoplasma.  The fungus lives in the environment, particularly in soil that contains large amounts of bird or bat droppings. In the United States, Histoplasma mainly lives in the central and eastern states, especially areas around the Ohio and Mississippi River valleys. The fungus also lives in parts of Central and South America, Africa, Asia, and Australia.

Wikipedia:63 Histoplasmosis (also known as \"cave disease,\" \"Darling\'s disease,\" \"Ohio valley disease,\"... more...

Aliases & Classifications for Histoplasmosis

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Sources:
9Disease Ontology, 11DISEASES, 47Orphanet, 32MedlinePlus, 3CDC, 60UMLS, 41NIH Rare Diseases, 43Novoseek, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Histoplasmosis, Aliases & Descriptions:

Name: Histoplasmosis 9 11 47 32 3 60
Reticuloendotheliosis 9 41 43
Reticuloendotheliosis, X-Linked 41 60
 
Infection by Histoplasma Capsulatum 60
Reticuloendothelial Hyperplasia 9
Darling Disease 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


External Ids:

Disease Ontology9 DOID:1731
ICD9CM27 115.9, 115
MeSH33 D006660
NCIt38 C77201
Orphanet47 390
MESH via Orphanet34 D006660
ICD10 via Orphanet26 B39.0, B39.1, B39.2 B39.3, B39.4, B39.5, B39.9, more
UMLS via Orphanet61 C0019655, C0153261
ICD1025 B39, B39.4, B39.9

Related Diseases for Histoplasmosis

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Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 253)
idRelated DiseaseScoreTop Affiliating Genes
1cryptococcosis31.0CD4
2syphilis30.8CD79A, CD4
3leprosy30.6CD4, HLA-DRB1
4meningitis30.6CD4, HLA-B, CD79A
5candidiasis30.5CD79A, CD4, IFNG
6toxoplasmosis30.5CD40LG, CD4, CD79A
7protein-losing enteropathy30.5TF
8prostatitis30.5CD79A, ACPP
9vasculitis30.4CD40LG, HLA-B, CD79A, TNF
10pneumonia30.3TNF, CD79A, CD4
11nephritis30.3CD79A, CD40LG, ACE
12eosinophilia30.1IFNG, STAT1, CD4, CD79A
13chronic lymphocytic leukemia30.1CD40LG, CD4, STAT1
14hepatitis30.1STAT1, HLA-B, HLA-A, SLC17A5, CD40LG, CD4
15hiv-130.1HLA-B, STAT1, ACPP, CD4, HLA-A
16inflammatory bowel disease29.9STAT1, IFNG, TNF, HLA-B
17tuberculosis29.7STAT1, CD79A, TNF, ACPP, HLA-A, IFNG
18connective tissue disease29.4TNF, HLA-A, HLA-DRB1, CD4, CD40LG, CD79A
19rheumatoid arthritis29.2HLA-A, TNF, STAT1, IFNG, CD4, CD79A
20arthritis29.2HLA-DRB1, HLA-A, ACPP, CD4, TNF, HLA-B
21systemic lupus erythematosus28.9HLA-DRB1, HLA-DQA1, HLA-A, CD40LG, TNF, STAT1
22hepatitis c28.9TF, HLA-A, HLA-DRB1, STAT1, IFNG, SLC17A5
23uveitis28.9HLA-B, HLA-A, IFNG, ACE, CD4, TNF
24leukemia28.5HLA-B, CD79A, ACPP, EGF, IFNG, CD40LG
25african histoplasmosis10.8
26fascioliasis10.6SLC17A5
27hemorrhagic fever10.6CD40LG
28dysentery10.6CD79A
29choroiditis10.6
30q fever10.5CD79A
31acquired immunodeficiency syndrome10.5
32blastomycosis10.5
33schnitzler syndrome10.5CD40LG
34macroglobulinemia10.5CD79A
35mycobacterium avium complex disease10.5CD4
36listeriosis10.5CD4
37aphthous stomatitis10.5HLA-B
38pemphigus10.5CD79A
39epidermolysis bullosa acquisita10.5CD79A
40sialadenitis10.5CD4
41intrapelvic lymph node leukemic reticuloendotheliosis10.4
42cryptosporidiosis10.4CD4, CD79A
43congenital toxoplasmosis10.4CD40LG, CD79A
44immunoglobulin g deficiency10.4CD79A, CD40LG
45selective iga deficiency disease10.4CD40LG, CD79A
46immunodeficiency, centromere instability and facial anomalies syndrome10.4CD40LG, CD79A
47immunoglobulin alpha deficiency10.4CD79A, CD40LG
48giant cell tumor10.4ATP6V1A, ACPP
49immunodeficiency, x-linked, with hyper-igm10.4CD40LG, CD79A
50chickenpox10.4CD4, CD79A

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to histoplasmosis

Symptoms for Histoplasmosis

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Symptoms:

 9
  • nonproductive cough
  • headache
  • loss of appetite
  • muscle pains

HPO human phenotypes related to Histoplasmosis:

(show all 6)
id Description Frequency HPO Source Accession
1 jaundice HP:0000952
2 x-linked inheritance HP:0001417
3 hepatosplenomegaly HP:0001433
4 anemia HP:0001903
5 lymphadenopathy HP:0002716
6 infantile onset HP:0003593

Drugs & Therapeutics for Histoplasmosis

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Drug clinical trials:

Search ClinicalTrials for Histoplasmosis

Search NIH Clinical Center for Histoplasmosis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Histoplasmosis

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Anatomical Context for Histoplasmosis

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MalaCards organs/tissues related to Histoplasmosis:

31
Lung, Testes, Colon, Skin, Bone, Bone marrow, Kidney, Lymph node, T cells, Tongue, B cells, Endothelial, Whole blood, Spleen, Brain, Retina, Spinal cord, Heart, Liver, Adrenal gland, Prostate, Myeloid, Trachea, Neutrophil

Animal Models for Histoplasmosis or affiliated genes

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MGI Mouse Phenotypes related to Histoplasmosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1HLA-B, TNF, STAT1, IFNG, CD4, CD79A
2MP:00107717.8TNF, STAT1, IFNG, ACPP, CD4, CD40LG
3MP:00036317.4HLA-B, TNF, STAT1, IFNG, CD4, CD79A
4MP:00053847.2TNF, STAT1, IFNG, ACE, CD4, CD79A
5MP:00053766.9TF, TNF, STAT1, IFNG, ACE, CD4
6MP:00053786.8TNF, STAT1, IFNG, ACE, CD4, EGF
7MP:00053976.7CD40LG, TF, HLA-B, HLA-DQA1, TNF, STAT1
8MP:00053876.6HLA-B, HLA-DQA1, TNF, STAT1, IFNG, ACE
9MP:00107686.4TF, HLA-B, TNF, STAT1, IFNG, ACE

Publications for Histoplasmosis

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Articles related to Histoplasmosis:

(show top 50)    (show all 669)
idTitleAuthorsYear
1
Histoplasmosis presenting with solitary pulmonary nodule: two cases mimicking pulmonary metastases. (25666013)
2015
2
Bilateral adrenal histoplasmosis in a man with chronic alcoholism. (25908247)
2015
3
Histoplasmosis Complicating Tumor Necrosis Factor-I+ Blocker Therapy: A Retrospective Analysis of 98 Cases. (25870331)
2015
4
Histoplasmosis in a state where it is not known to be endemic-montana, 2012-2013. (24354878)
2014
5
18F FDG PET/CT identifies unsuspected bilateral adrenal histoplasmosis in an elderly immuno compromised patient. (25027093)
2014
6
Application of nested PCR for diagnosis of histoplasmosis. (23345048)
2013
7
Adrenal hypofunction from histoplasmosis: a literature review from 1971 to 2012. (23771479)
2013
8
Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis. (23541320)
2013
9
Unusual presentations of disseminated histoplasmosis. (22715652)
2012
10
Disseminated cutaneous histoplasmosis in an immunocompetent adult. (22707773)
2012
11
Disseminated histoplasmosis and haemophagocytic syndrome in two kidney transplant patients. (23013962)
2012
12
Histoplasmosis infection in patients with rheumatoid arthritis, 1998-2009. (21605439)
2011
13
Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. (21911464)
2011
14
Adrenal histoplasmosis: An unusual cause of adrenomegaly. (22022092)
2011
15
Pulmonary histoplasmosis. (22167401)
2011
16
Clinical and evolutionary characteristics of four patients with pulmonary histoplasmosis reported in the ParaA-ba Paulista Valley region. (21085880)
2010
17
Disseminated histoplasmosis presenting with chronic ulcerative tongue lesions in a patient with diabetes. (22791841)
2010
18
Imported histoplasmosis: two distinct profiles in travelers and immigrants. (19674266)
2009
19
Disseminated histoplasmosis presenting as granulomatous epididymo-orchitis. (19745612)
2009
20
Disseminated histoplasmosis by Histoplasma capsulatum var. duboisii in a paediatric patient from the Chad Republic, Africa. (19005708)
2009
21
Case report: Esophageal histoplasmosis associated with disseminated tuberculosis in acquired immunodeficiency syndrome. (19270280)
2009
22
Histoplasmosis in children. (19879506)
2009
23
First case report of histoplasmosis in a cat in Japan. (20046039)
2009
24
Oral histoplasmosis: an unusual presentation. (18798316)
2009
25
Education and imaging. Gastrointestinal: Gastrointestinal histoplasmosis. (18397490)
2008
26
Outbreak of histoplasmosis among travelers returning from El Salvador--Pennsylvania and Virginia, 2008. (19092757)
2008
27
Images in emergency medicine. Erythema nodosum associated with pulmonary histoplasmosis. (19027494)
2008
28
Mediastinal lymphatic drainage from pulmonary lobe based on CT observations of histoplasmosis: implications for minimal N2 disease of non-small-cell lung cancer. (17952543)
2007
29
Disseminated histoplasmosis and tuberculosis in a patient with HIV infection. (17594164)
2007
30
Platelia Aspergillus assay for diagnosis of disseminated histoplasmosis. (17874253)
2007
31
Laryngeal histoplasmosis as a mimicker of squamous cell carcinoma: imaging and histologic findings. (18225621)
2007
32
Tumor necrosis factor-alpha antagonism by the murine tumor necrosis factor-alpha receptor 2-Fc fusion protein exacerbates histoplasmosis in mice. (17572011)
2007
33
Penoscrotal histoplasmosis following bladder carcinoma. (17593111)
2007
34
Histoplasmosis-associated cross-reactivity in the BioRad Platelia Aspergillus enzyme immunoassay. (17344352)
2007
35
Molecular epidemiology of canine histoplasmosis in Japan. (17464845)
2007
36
Disseminated histoplasmosis mimicking laryngeal carcinoma from central India--a case report. (17001921)
2006
37
Disseminated histoplasmosis presenting as thrombotic microangiopathy. (16836570)
2006
38
Gastric histoplasmosis. (16377536)
2006
39
Cases of histoplasmosis reported in Taiwan. (16877229)
2006
40
Preventing reactivation of ocular histoplasmosis: guidance for patients at risk. (16458241)
2006
41
Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like). (16419421)
2005
42
Association of the HLA-DR15/HLA-DQ6 haplotype with development of choroidal neovascular lesions in presumed ocular histoplasmosis syndrome. (14522093)
2003
43
Histoplasmosis-like choroiditis in a nonendemic area: the northwest United States. (9654410)
1998
44
African histoplasmosis: a review. (15538817)
1997
45
Focal lesion of African histoplasmosis presenting as a malignant gastric ulcer. (8799429)
1996
46
Mandibular African histoplasmosis: imitation of neoplasia or giant-cell granuloma? (3422400)
1988
47
Multifocal choroiditis and panuveitis. A syndrome that mimics ocular histoplasmosis. (6508619)
1984
48
Maxillary African histoplasmosis mimicking malignant jaw tumour. (285725)
1979
49
EXPERIMENTAL OCULAR HISTOPLASMOSIS. VI. FLUORESCEIN FUNDUS PHOTOGRAPHS OF CHOROIDITIS IN THE PRIMATE. (14233705)
1964
50
African histoplasmosis of the lungs with diffuse suppuration appearing after a year's development]. (13654699)
1959

Variations for Histoplasmosis

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Expression for genes affiliated with Histoplasmosis

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Search GEO for disease gene expression data for Histoplasmosis.

Pathways for genes affiliated with Histoplasmosis

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Pathways related to Histoplasmosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CD4, CD79A, CD40LG
2
Show member pathways
9.6CD4, HLA-DRB1, HLA-DQA1
3
Show member pathways
9.6CD4, HLA-DRB1, HLA-DQA1
4
Show member pathways
9.6CD4, HLA-DRB1, HLA-DQA1
5
Show member pathways
9.6HLA-B, HLA-A, STAT1
69.5HLA-DRB1, STAT1, CD4
79.5CD40LG, HLA-A, HLA-B
8
Show member pathways
TCR signaling in naive CD8+ T cells36
9.5CD4, HLA-DRB1, HLA-A
9
Show member pathways
9.4STAT1, IFNG, CD4
109.4IFNG, STAT1, HLA-B
11
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
9.4HLA-DQA1, HLA-DRB1, CD4, CD79A
12
Show member pathways
9.3CD4, STAT1, HLA-DRB1, HLA-DQA1
139.3CD4, IFNG, HLA-DRB1
14
Show member pathways
9.2HLA-DRB1, HLA-DQA1, HLA-A, HLA-B
159.1EGF, IFNG, TF
169.0HLA-DRB1, TNF, CD4
17
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.9IFNG, STAT1, TNF
18
Show member pathways
Immune response MIF in innate immunity response58
8.9TNF, STAT1, IFNG
19
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
8.9HLA-DQA1, HLA-DRB1, STAT1, CD4, EGF
20
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.8TNF, IFNG, CD40LG
218.8TNF, IFNG, CD40LG
22
Show member pathways
8.8HLA-A, HLA-DQA1, TNF, CD40LG
23
Show member pathways
Ras signaling in the CD4+ TCR pathway36
8.8HLA-A, TNF, IFNG
248.7ATP6V1A, HLA-B, HLA-A, HLA-DQA1, HLA-DRB1
25
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.7HLA-A, HLA-DRB1, STAT1, IFNG, CD4
26
Show member pathways
8.6HLA-DQA1, HLA-DRB1, STAT1, CD4, CD79A, EGF
278.6HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, CD4, CD40LG
28
Show member pathways
IL27-mediated signaling events36
8.6TNF, STAT1, IFNG, CD4
29
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.6TNF, STAT1, IFNG, CD4
308.5CD4, IFNG, TNF, HLA-DRB1
31
Show member pathways
8.4HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, STAT1, IFNG
328.4EGF, IFNG, STAT1, TNF
338.4TNF, STAT1, IFNG, EGF
348.4HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, POLR3B, IFNG
358.4HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, TNF
36
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.3CD40LG, CD79A, CD4, IFNG, TNF
378.3HLA-DQA1, HLA-DRB1, TNF, STAT1, IFNG
38
Show member pathways
Immune response CD16 signaling in NK cells58
8.3HLA-B, HLA-A, TNF, MICA, IFNG
39
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.3TNF, STAT1, IFNG, ACE
40
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.2CD4, IFNG, TNF, HLA-A, HLA-B
41
Show member pathways
8.1TNF, STAT1, IFNG, CD4, EGF
42
Show member pathways
8.1EGF, CD4, IFNG, STAT1, TNF
43
Show member pathways
8.1TNF, IFNG, CD4, CD40LG, EGF
448.0ATP6V1A, HLA-DQA1, HLA-DRB1, TNF, IFNG
45
Show member pathways
8.0HLA-DQA1, HLA-DRB1, TNF, STAT1, IFNG, CD40LG
46
Show member pathways
8.0HLA-DQA1, HLA-DRB1, TNF, POLR3B, IFNG, CD40LG
47
Show member pathways
7.9HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, CD4, CD79A
48
Show member pathways
7.6HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, TNF, STAT1
49
Show member pathways
7.6HLA-DQA1, HLA-DRB1, TNF, STAT1, IFNG, CD79A
50
Show member pathways
7.1CD40LG, HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, TNF

Compounds for genes affiliated with Histoplasmosis

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Compounds related to Histoplasmosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1pneumococcal439.8HLA-B, CD79A, CD40LG, SLC17A5
2hemocyanin439.8CD79A, CD40LG, CD4
3phenytoin43 49 28 1212.7CD79A, HLA-B, SLC17A5, CD40LG
4gliadin439.7CD79A, STAT1, CD40LG
5tuberculin439.7CD40LG, CD79A, IFNG
6ursodeoxycholic acid43 24 1211.7HLA-B, SLC17A5, CD40LG, HLA-A
7gamma globulin439.6SLC17A5, IFNG, CD40LG, CD79A
8vitamin b12439.6TF, CD79A, SLC17A5, CD40LG
9antipyrine43 1210.5SLC17A5, HLA-B, TF
10polyethylene glycol439.5TF, CD40LG, CD79A, SLC17A5
11blys439.4TNF, CD79A, CD40LG
12allergens439.4CD40LG, CD79A, IFNG, HLA-DRB1
13agar439.2TF, EGF, CD40LG, CD79A, ACPP
14paraffin439.2HLA-DQA1, HLA-B, CD40LG, CD79A, TF, ACPP
15phosphotyrosine439.2ACPP, HLA-B, STAT1, EGF, CD4
16lapatinib43 49 1211.1HLA-DRB1, HLA-DQA1, EGF
17aspartate439.0TF, HLA-DQA1, ACPP, CD40LG, SLC17A5, HLA-B
18okt3439.0CD40LG, CD79A, TNF, IFNG
19polysaccharide439.0CD40LG, CD79A, CD4, HLA-B, TF
20gold sodium thiomalate439.0HLA-DRB1, TNF, IFNG
21mycophenolate mofetil43 49 1211.0CD79A, CD40LG, IFNG, TNF
22ivig439.0IFNG, CD79A, TNF, CD40LG
23carbamazepine43 49 1211.0SLC17A5, TNF, CD79A, HLA-B, HLA-A
24polyinosinic-polycytidylic acid438.9HLA-B, IFNG, TNF, STAT1
252,5-oligoadenylate438.9IFNG, HLA-B, STAT1, TNF
26chloroquine43 2 49 28 1212.9CD79A, TF, TNF, CD4
27ribavirin43 49 1210.9SLC17A5, TF, HLA-B, STAT1, IFNG, CD40LG
28oligonucleotide438.8HLA-B, HLA-A, HLA-DRB1, STAT1, ACPP, HLA-DQA1
29methotrexate49 43 1210.7CD79A, SLC17A5, HLA-DRB1, TNF, TF
30prednisolone43 28 1210.7CD79A, TF, IFNG, SLC17A5, TNF
31n acetylcysteine438.7CD79A, TF, TNF, STAT1, SLC17A5, CD40LG
32creatinine438.6ACE, ACPP, CD40LG, TF, SLC17A5, CD79A
33fibrinogen438.6HLA-B, TF, CD79A, TNF, CD40LG, SLC17A5
34alanine438.5HLA-DRB1, TF, SLC17A5, CD40LG, CD79A, ACPP
35cholesterol43 28 24 1211.5HLA-B, TF, ACPP, ACE, STAT1, SLC17A5
36endotoxin438.5HLA-B, TNF, CD40LG, STAT1, IFNG, SLC17A5
37rantes438.4CD4, IFNG, STAT1, TNF, CD40LG, HLA-B
38lactate438.4SLC17A5, ACPP, CD40LG, TF, TNF, HLA-B
39neopterin438.3TNF, ACPP, CD4, CD79A, CD40LG, SLC17A5
40indomethacin43 28 59 1211.3TNF, STAT1, CD79A, IFNG, CD40LG, EGF
41herbimycin a43 599.3STAT1, TNF, EGF, CD40LG, CD4, IFNG
42genistein43 28 59 2 24 1213.2TNF, IFNG, CD4, STAT1, CD40LG, EGF
43arginine438.2ACPP, IFNG, STAT1, HLA-DRB1, CD40LG, CD79A
44h2o2438.1SLC17A5, EGF, STAT1, TNF, CD79A, HLA-B
45tacrolimus43 49 1210.0TNF, IFNG, TF, HLA-B, CD79A, SLC17A5
46dexamethasone43 49 28 1210.9CD79A, IFNG, HLA-B, EGF, CD40LG, TNF
47vegf437.7EGF, CD40LG, TNF, STAT1, CD79A, ACPP
48retinoic acid43 248.7CD79A, IFNG, TNF, HLA-B, EGF, CD40LG
49cyclosporin a43 28 599.5STAT1, SLC17A5, CD40LG, CD79A, IFNG, TF
50pge2437.3TNF, TF, HLA-B, CD40LG, CD79A, CD4

GO Terms for genes affiliated with Histoplasmosis

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Cellular components related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1multivesicular bodyGO:00057719.9CD79A, ACPP
2MHC class I protein complexGO:00426129.9HLA-A, HLA-B
3MHC class II protein complexGO:00426139.9HLA-DQA1, HLA-DRB1
4integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.4HLA-B, HLA-A, HLA-DQA1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:00125079.4HLA-B, HLA-A, HLA-DQA1, HLA-DRB1
6Golgi membraneGO:00001399.2HLA-DRB1, HLA-DQA1, HLA-A, HLA-B
7membrane raftGO:00451218.8TNF, CD4, CD79A
8lysosomal membraneGO:00057658.7ATP6V1A, HLA-DQA1, HLA-DRB1, ACPP, EGF, SLC17A5
9cell surfaceGO:00099868.5TF, HLA-B, HLA-A, TNF, MICA
10external side of plasma membraneGO:00098977.6CD40LG, HLA-DRB1, TNF, IFNG, ACE, CD4
11integral component of plasma membraneGO:00058877.4ATP6V1A, HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, TNF
12extracellular vesicular exosomeGO:00700627.4TF, ATP6V1A, HLA-B, HLA-A, HLA-DRB1, ACPP
13extracellular spaceGO:00056157.1TF, TNF, MICA, IFNG, ACPP, ACE
14plasma membraneGO:00058865.8ATP6V1A, HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, TNF

Biological processes related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:000248610.1HLA-A, HLA-B
2negative regulation of metanephric nephron tubule epithelial cell differentiationGO:007230810.0IFNG, STAT1
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:000248010.0HLA-A, HLA-B
4negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:000334010.0IFNG, STAT1
5type I interferon signaling pathwayGO:00603379.8HLA-B, HLA-A, STAT1
6T cell costimulationGO:00312959.8CD4, HLA-DRB1, HLA-DQA1
7detection of bacteriumGO:00160459.8HLA-DRB1, HLA-A, HLA-B
8T cell receptor signaling pathwayGO:00508529.7HLA-DQA1, HLA-DRB1, CD4
9regulation of interferon-gamma-mediated signaling pathwayGO:00603349.7STAT1, IFNG
10regulation of immune responseGO:00507769.7CD40LG, HLA-A, HLA-B
11regulation of immunoglobulin secretionGO:00510239.7TNF, CD40LG
12defense response to virusGO:00516079.6POLR3B, STAT1, MICA, IFNG
13positive regulation of T cell mediated cytotoxicityGO:00019169.5HLA-A, HLA-B
14positive regulation of vitamin D biosynthetic processGO:00605579.5IFNG, TNF
15positive regulation of calcidiol 1-monooxygenase activityGO:00605599.4IFNG, TNF
16positive regulation of chemokine biosynthetic processGO:00450809.4IFNG, TNF
17viral processGO:00160329.3CD4, MICA, STAT1, HLA-A, HLA-B
18immune responseGO:00069559.2HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, CD4
19positive regulation of membrane protein ectodomain proteolysisGO:00510449.2IFNG, TNF
20negative regulation of growth of symbiont in hostGO:00441309.2IFNG, TNF
21protein import into nucleus, translocationGO:00000609.1IFNG, TNF
22positive regulation of osteoclast differentiationGO:00456729.0IFNG, TNF
23interferon-gamma-mediated signaling pathwayGO:00603338.8IFNG, STAT1, HLA-DRB1, HLA-DQA1, HLA-A, HLA-B
24cytokine-mediated signaling pathwayGO:00192218.8HLA-B, HLA-A, HLA-DQA1, HLA-DRB1, STAT1, IFNG

Molecular functions related to Histoplasmosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TAP bindingGO:00469779.7HLA-B, HLA-A
2MHC class II receptor activityGO:00323959.6HLA-DRB1, HLA-DQA1
3peptide antigen bindingGO:00426059.4HLA-DRB1, HLA-A, HLA-B
4tumor necrosis factor receptor bindingGO:00051649.2CD40LG, STAT1, TNF
5cytokine activityGO:00051258.8CD40LG, IFNG, TNF

Products for genes affiliated with Histoplasmosis

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Sources for Histoplasmosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
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