MCID: HST011
MIFTS: 65

Histoplasmosis malady

Infectious diseases category

Summaries for Histoplasmosis

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Histoplasmosis is a disease caused by a fungus (or mold) called histoplasma. the fungus is common in the eastern and central united states. it grows in soil and material contaminated with bat or bird droppings. you get infected by breathing the fungal spores. you cannot get the infection from someone else. histoplasmosis is often mild, with no symptoms. if you do get sick, it usually affects your lungs. symptoms include feeling ill, fever, chest pains, and a dry cough. in severe cases, histoplasmosis spreads to other organs. this is called disseminated disease. it is more common in infants, young children, seniors, and people with immune system problems. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. mild cases usually get better without treatment. treatment of severe or chronic cases is with antifungal drugs. centers for disease control and prevention

MalaCards: Histoplasmosis, also known as reticuloendotheliosis, is related to acquired immunodeficiency syndrome and coccidioidomycosis, and has symptoms including muscle pains, loss of appetite and headache. An important gene associated with Histoplasmosis is RP9 (retinitis pigmentosa 9 (autosomal dominant)), and among its related pathways are Immune response T cell receptor signaling pathway and Primary immunodeficiency. The drugs fluconazole and ketoconazole and the compounds pge2 and sulfolipid i have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and colon, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection, has material basis in histoplasma capsulatum var capsulatum or has material basis in histoplasma capsulatum var duboisii, transmitted by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

CDC:3 Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum.  The fungus lives in the environment, usually in association with large amounts of bird or bat droppings. Lung infection can occur after a person inhales airborne, microscopic fungal spores from the environment; however, many people who inhale the spores do not get sick. The symptoms of histoplasmosis are similar to pneumonia, and the infection can sometimes become serious if it is not treated.

Wikipedia:63 Histoplasmosis (also known as \"Cave disease,\" \"Darling\'s disease,\" \"Ohio valley disease,\"... more...

Aliases & Classifications for Histoplasmosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

histoplasmosis 8 10 48 33 60
reticuloendotheliosis 8 42 44
reticuloendotheliosis, x-linked 42 60
infection by histoplasma capsulatum 60
reticuloendothelial hyperplasia 8
darling disease 48


External Ids:

Disease Ontology8 DOID:1731
ICD9CM27 115, 115.9
NCIt39 C77201
MeSH34 D006660
ICD10 via Orphanet26 B39.0, B39.2, B39.3 B39.4, B39.1, B39.5, B39.9, more
MESH via Orphanet35 D006660
SNOMED-CT via Orphanet57 12962009, 76255006
UMLS via Orphanet61 C0019655, C0153261
ICD1025 B39, B39.4, B39.9

Related Diseases for Histoplasmosis

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17GeneCards, 18GeneDecks
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Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1acquired immunodeficiency syndrome30.7HLA-B, CD4
2coccidioidomycosis30.4CLEC7A
3tuberculosis30.4CD4, CD79A, CLEC7A, ACPP
4addison's disease30.2MICA
5candidiasis30.1CD79A, CD4
6lung cancer30.1CD4
7lupus erythematosus30.1CD40LG, CD79A
8sarcoidosis30.1CD80, CD4
9syphilis30.1CD4, CD79A
10meningitis30.0CD79A, CD4, HLA-B
11rheumatoid arthritis30.0CD79A, CD80, CD40LG, CD4
12arthritis30.0ACPP, CD80, CD4, HLA-B
13hepatitis30.0SLC17A5, CD40LG, CD4, HLA-B
14vasculitis30.0HLA-B, CD40LG, CD80, CD79A
15leprosy29.9CD4
16inflammatory bowel disease29.9CD4, CD79A
17toxoplasmosis29.9CD4, CD40LG, CD79A
18systemic lupus erythematosus29.9HLA-DQA1, CD4, CD40LG, CD80, CD79A
19myocarditis29.7CD4
20pneumonia29.7CD4, CD79A
21uveitis29.7HLA-B, CD4
22myositis29.7HLA-B, SLC17A5
23connective tissue disease29.7CD4, CD40LG, CD79A
24hepatitis c29.7SLC17A5, CD40LG, CD4
25burkitt's lymphoma29.7HLA-B, CD4, CD40LG, CD80, CD79A, REL
26leukemia29.7HLA-B, CD4, CD40LG, CD80, CD79A, REL
27african histoplasmosis10.7
28letterer-siwe disease10.5
29choroiditis10.5
30blastomycosis10.5
31american histoplasmosis10.3
32intrapelvic lymph node leukemic reticuloendotheliosis10.3
33lymphangitis10.3
34paracoccidioidomycosis10.3
35laryngitis10.3
36mediastinitis10.3
37histoplasmosis meningitis10.2
38histoplasmosis pericarditis10.2
39penicilliosis10.2
40laryngeal carcinoma10.2
41histoplasmosis retinitis10.1
42hypercalcemia10.1
43hairy cell leukemia of spleen10.1
44hairy cell leukemia10.1
45job's syndrome10.1
46pancytopenia10.1
47chronic mucocutaneous candidiasis10.1
48cryptococcosis10.1
49chorioretinitis10.1
50interstitial nephritis10.1

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to histoplasmosis

Clinical Features for Histoplasmosis

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Sources:
8Disease Ontology
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Symptoms:

8
  • muscle pains
  • loss of appetite
  • headache
  • nonproductive cough

Drugs & Therapeutics for Histoplasmosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Histoplasmosis

Drug clinical trials:

Search ClinicalTrials for Histoplasmosis

Search NIH Clinical Center for Histoplasmosis

Search CenterWatch for Histoplasmosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Histoplasmosis

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Anatomical Context for Histoplasmosis

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32MalaCards
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MalaCards organs/tissues related to Histoplasmosis:

32
Lung, Testes, Colon, Skin, Bone, Bone marrow, Kidney, T cells, B cells, Tongue, Lymph node, Retina, Endothelial, Myeloid, Prostate, Whole blood, Adrenal gland, Liver, Spleen, Brain, Heart, Spinal cord

Animal Models for Histoplasmosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Histoplasmosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.9HLA-B, HLA-DQA1, CD4, CD40LG, CD80, CD79A
2MP:00053878.4CLEC7A, TIPARP, HLA-B, HLA-DQA1, CD4, CD40LG

Publications for Histoplasmosis

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Sources:
50PubMed
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Articles related to Histoplasmosis:

(show top 50)    (show all 628)
idTitleAuthorsYear
1
Histoplasmosis outbreak associated with the renovation of an old house - quebec, Canada, 2013. (24381077)
2014
2
Evaluation of commercially available reagents for diagnosis of histoplasmosis infection in immunocompromised patients. (24088857)
2013
3
Fine-needle aspiration of histoplasmosis in the era of endoscopic ultrasound and endobronchial ultrasound: cytomorphologic features and correlation with clinical laboratory testing. (23677891)
2013
4
Gastrointestinal histoplasmosis in a hepatitis C-infected individual. (23760983)
2013
5
A multinational outbreak of histoplasmosis following a biology field trip in the Ugandan rainforest. (23464714)
2013
6
A case in Europe of feline histoplasmosis apparently limited to the skin. (24118343)
2013
7
Primary localized histoplasmosis: oral manifestations in immunocompetent patients. (23219033)
2013
8
Oral medicine case book 40: oral histoplasmosis. (23185949)
2012
9
Oral exfoliative cytology in the diagnosis of histoplasmosis. (21366735)
2012
10
Skin lesions in histoplasmosis. (23068146)
2012
11
Disseminated histoplasmosis in a juvenile lupus erythematosus patient. (23348119)
2012
12
Pulmonary histoplasmosis. (22167401)
2011
13
Bilateral adrenal histoplasmosis: endoscopic ultrasound-guided fine needle aspiration as a method of diagnosis and assessment. (22390113)
2011
14
Granulomatous pleuritis caused by histoplasmosis in a healthy child. (21634031)
2011
15
Disseminated histoplasmosis presenting as AIDS cholangiopathy. (19821907)
2011
16
A multicenter evaluation of tests for diagnosis of histoplasmosis. (21810734)
2011
17
Oral presentation of disseminated histoplasmosis: a case report and literature review. (21145642)
2011
18
Clinical and evolutionary characteristics of four patients with pulmonary histoplasmosis reported in the ParaA-ba Paulista Valley region. (21085880)
2010
19
Chronic disseminated histoplasmosis with prolonged latency. (20600299)
2010
20
Disseminated histoplasmosis manifested by laryngopharyngeal and adrenal lesions in an HIV-negative individual. (21510541)
2010
21
Disseminated histoplasmosis in an AIDS patient: a rare case from southern India. (19762585)
2009
22
Histoplasmosis in fine-needle aspiration cytology of axillary lymph node in an HIV-positive woman with clinical suspicion of lymphoma. (18973264)
2009
23
Histoplasmosis in solid organ transplant recipients: early diagnosis and treatment. (19812496)
2009
24
Chronic cavitary pulmonary histoplasmosis. (20011854)
2009
25
Successful treatment of histoplasmosis brain abscess with voriconazole. (18474746)
2008
26
Histoplasmosis in Europe: report on an epidemiological survey from the European Confederation of Medical Mycology Working Group. (17885939)
2008
27
Intravitreal bevacizumab for choroidal neovascularization in ocular histoplasmosis. (18321466)
2008
28
Platelia Aspergillus assay for diagnosis of disseminated histoplasmosis. (17874253)
2007
29
Disseminated histoplasmosis. (17295324)
2007
30
Histoplasmosis as a cause of nodular myositis in an AIDS patient diagnosed on fine needle aspiration cytology. A case report. (17328504)
2007
31
Histoplasmosis in a child with JRA on low-dose methotrexate. (17114804)
2007
32
Histoplasmosis. (17489105)
2007
33
Disseminated histoplasmosis presenting as a unilateral cranial nerve VIII mass: a case report. (17006352)
2006
34
Fever and high lactate dehydrogenase in HIV-positive patients from the Antilles and Surinam: histoplasmosis? (16990694)
2006
35
Cutaneous histoplasmosis in 13 Ethiopian donkeys. (16782861)
2006
36
Improvements in diagnosis of histoplasmosis. (17049017)
2006
37
Pulmonary inflammatory myofibroblastic tumor associated with histoplasmosis. (17670634)
2006
38
Progress in vaccination for histoplasmosis and blastomycosis: coping with cellular immunity. (16178365)
2005
39
Disseminated histoplasmosis: a comparative study between patients with acquired immunodeficiency syndrome and non-human immunodeficiency virus-infected individuals. (16172484)
2005
40
Disseminated Histoplasmosis Mimicking Felty's Syndrome. (17039199)
2002
41
Disseminated histoplasmosis presenting as pyoderma gangrenosum-like lesions in a patient with acquired immunodeficiency syndrome. (11703524)
2001
42
Adrenal histoplasmosis manifested as Addison's disease: unusual CT features with magnetic resonance imaging correlation. (11467874)
2001
43
Histoplasmosis and Paracoccidioidomycosis in northwestern Argentina III. Epidemiological survey in Vipos, La Toma, and Choromoro - Trancas, TucumA!n, Argentina. (10414381)
1999
44
Histoplasmosis in northwestern Argentina. II: Prevalence of Histoplasmosis capsulati and paracoccidioidomycosis in the population south of Chuscha, Gonzalo and Potrero in the province of Tucuman. (7617013)
1995
45
Intestinal perforation from gastrointestinal histoplasmosis in acquired immunodeficiency syndrome. Case report and review of the literature. (8457161)
1993
46
Itraconazole therapy for blastomycosis and histoplasmosis. NIAID Mycoses Study Group. (1332471)
1992
47
Histoplasmosis duboisii (African histoplasmosis). An African case reported from Chile with ultrastructural study. (2247379)
1990
48
African histoplasmosis masquerading as carcinoma of the colon. Report of a case and review of literature. (2676427)
1989
49
The concept of invisible choroiditis in the ocular histoplasmosis syndrome. (6189799)
1983
50
African histoplasmosis of the lungs with diffuse suppuration appearing after a year's development]. (13654699)
1959

Genetic Variations for Histoplasmosis

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Expression for genes affiliated with Histoplasmosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Histoplasmosis

Search GEO for disease gene expression data for Histoplasmosis.

Pathways for genes affiliated with Histoplasmosis

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Sources:
12EMD Millipore, 29KEGG, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Histoplasmosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0REL, CD4, HLA-DQA1
29.9CD4, CD40LG, CD79A
39.9ATP6V1A, CD80
4
Immune response ICOS pathway in T-helper cell
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9.9REL, CD80, HLA-DQA1
5
Hide members
9.8HLA-DQA1, CD4, CD80
6
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9.8REL, CD79A, MICA, HLA-B
7
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9.8CD4, CD40LG, CD79A, REL
8
Immune response NFAT in immune response
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9.7REL, CD79A, CD80, HLA-DQA1
99.7CLEC7A, ATP6V1A, HLA-DQA1, HLA-B
109.5HLA-B, HLA-DQA1, CD4, CD40LG, CD80
11
Hide members
9.5HLA-B, HLA-DQA1, CD4, CD40LG, CD80
12
Hide members
8.8REL, HLA-B, HLA-DQA1, POLR3B, MICA, CD4

Compounds for genes affiliated with Histoplasmosis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Histoplasmosis according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1pge24410.6CD4
2sulfolipid i4410.5CD40LG, CD79A
3sandoglobulin4410.5CD79A, CD40LG
4hemocyanin4410.3CD79A, CD40LG, CD4
5mannan4410.3CD79A, CD40LG, CD4
6anti-fungal4410.3REL, CD79A, CD40LG
7lactulose4410.3SLC17A5, CD79A
8valproate4410.3SLC17A5, CD79A, CD40LG
9vancomycin44 1111.3CD40LG, CD79A
10ursodeoxycholic acid44 11 2412.3SLC17A5, CD40LG, HLA-B
11ribavirin44 49 1112.2SLC17A5, CD40LG, HLA-B
12vitamin b124410.2SLC17A5, CD79A, CD40LG
13carbamazepine44 49 1112.2HLA-B, CD79A, SLC17A5
14pneumococcal4410.1SLC17A5, CD79A, CD40LG, HLA-B
15tuberculin4410.1CD79A, CD40LG
16phenytoin44 49 28 1113.1SLC17A5, CD79A, CD40LG, HLA-B
17tacrolimus44 49 1112.1HLA-B, CD79A, REL, SLC17A5
18rituximab44 49 1112.1CD40LG, CD80, CD79A
19allergens4410.0CD79A, CD80, CD40LG
20mannose4410.0CD4, CD80, CD79A, CLEC7A
21blys4410.0CD79A, CD40LG
22polyethylene glycol4410.0CD40LG, CD79A, SLC17A5
23rantes4410.0HLA-B, CD4, CD40LG, REL
24polysaccharide449.8CD79A, CD40LG, CD4, HLA-B
25neopterin449.8CD4, CD40LG, CD79A, SLC17A5, ACPP
26paraffin449.8HLA-B, HLA-DQA1, CD40LG, CD79A, ACPP
27fibrinogen449.7SLC17A5, CD79A, CD40LG, HLA-B
28lactate449.7HLA-B, CD40LG, CD79A, SLC17A5, ACPP
29aspartate449.7HLA-B, HLA-DQA1, CD40LG, SLC17A5, ACPP
30creatinine449.7ACPP, SLC17A5, CD79A, CD40LG, HLA-B
31cyclosporin a44 28 5911.7HLA-B, CD40LG, CD80, CD79A, REL, SLC17A5
32dexamethasone44 49 28 1112.7HLA-B, CD40LG, CD80, CD79A, REL, CLEC7A
33testosterone44 59 11 2412.1HLA-B, CD40LG, CD79A, SLC17A5, ACPP

GO Terms for genes affiliated with Histoplasmosis

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16Gene Ontology
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Cellular components related to Histoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomal membraneGO:0057659.5ACPP, SLC17A5, ATP6V1A, HLA-DQA1
2external side of plasma membraneGO:0098979.4CLEC7A, CD79A, CD80, CD40LG, CD4
3integral to plasma membraneGO:0058878.8HLA-B, HLA-DQA1, ATP6V1A, MICA, CD40LG, GPR22

Biological processes related to Histoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.0CD79A, CD40LG
2T cell costimulationGO:0312959.8CD80, CD4, HLA-DQA1
3positive regulation of interleukin-2 biosynthetic processGO:0450869.7CD4, CD80
4innate immune responseGO:0450879.5CLEC7A, CD80, CD4, POLR3B, HLA-B

Molecular functions related to Histoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proton-transporting ATPase activity, rotational mechanismGO:04696110.0ATP6V1A, ATP5A1

Products for genes affiliated with Histoplasmosis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Histoplasmosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet