MCID: HST011
MIFTS: 56

Histoplasmosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Histoplasmosis

MalaCards integrated aliases for Histoplasmosis:

Name: Histoplasmosis 12 72 55 40 3 41 14 69
Infection by Histoplasma Capsulatum 69
Reticuloendotheliosis, X-Linked 41
Darling Disease 55

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1731
ICD10 32 B39 B39.9 B39.4
ICD9CM 34 115 115.9
Orphanet 55 ORPHA390
MESH via Orphanet 42 D006660
UMLS via Orphanet 70 C0019655 C0153261
ICD10 via Orphanet 33 B39.0 B39.1 B39.2 more

Summaries for Histoplasmosis

MedlinePlus : 40 Histoplasmosis is a disease caused by a fungus (or mold) called Histoplasma. The fungus is common in the eastern and central United States. It grows in soil and material contaminated with bat or bird droppings. You get infected by breathing the fungal spores. You cannot get the infection from someone else. Histoplasmosis is often mild, with no symptoms. If you do get sick, it usually affects your lungs. Symptoms include feeling ill, fever, chest pains, and a dry cough. In severe cases, histoplasmosis spreads to other organs. This is called disseminated disease. It is more common in infants, young children, seniors, and people with immune system problems. Your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, CT scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. Mild cases usually get better without treatment. Treatment of severe or chronic cases is with antifungal drugs. Centers for Disease Control and Prevention

MalaCards based summary : Histoplasmosis, also known as infection by histoplasma capsulatum, is related to panuveitis and arthritis, and has symptoms including nonproductive cough, headache and loss of appetite. An important gene associated with Histoplasmosis is ATP6V1A (ATPase H+ Transporting V1 Subunit A), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Influenza A. The drugs Bevacizumab and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and colon, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

CDC : 3 Histoplasmosis is an infection caused by a fungus called Histoplasma. The fungus lives in the environment, particularly in soil that contains large amounts of bird or bat droppings. In the United States, Histoplasma mainly lives in the central and eastern states, especially areas around the Ohio and Mississippi River valleys. The fungus also lives in parts of Central and South America, Africa, Asia, and Australia.

Disease Ontology : 12 A primary systemic mycosis that results_in systemic fungal infection, has material basis in Histoplasma capsulatum var capsulatum or has material basis in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

Wikipedia : 72 Histoplasmosis (also known as \"Cave disease\", \"Darling\'s disease\", \"Ohio valley disease\",... more...

Related Diseases for Histoplasmosis

Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
# Related Disease Score Top Affiliating Genes
1 panuveitis 29.9 HLA-B HLA-DRB1
2 arthritis 29.3 HLA-DRB1 IFNG MICA
3 connective tissue disease 29.1 HLA-DRB1 IFNG MICA
4 inflammatory bowel disease 29.0 HLA-B HLA-DRB1 IFNG STAT1
5 african histoplasmosis 12.4
6 american histoplasmosis 12.3
7 reticuloendotheliosis, x-linked 12.2
8 histoplasmosis pericarditis 12.1
9 histoplasmosis retinitis 12.0
10 histoplasmosis meningitis 12.0
11 blastomycosis 11.3
12 fibrosing mediastinitis 11.2
13 reticuloendotheliosis 11.0
14 rickets 10.9
15 chronic rhinitis 10.9
16 phenytoin or carbamazepine toxicity 10.4 HLA-A HLA-B
17 baylisascariasis 10.4 ATP6V1A IFNG
18 atrial tachyarrhythmia with short pr interval 10.4 HLA-A HLA-B
19 glaucomatocyclitic crisis 10.4 HLA-A HLA-B
20 microscopic polyangiitis 10.4 HLA-B HLA-DRB1
21 cytomegalovirus retinitis 10.4 HLA-B IFNG
22 idiopathic inflammatory myopathy 10.4 HLA-B HLA-DRB1
23 anterior uveitis 10.4 HLA-A HLA-B
24 chronic pyelonephritis 10.4 HLA-A HLA-B
25 intermediate uveitis 10.4 HLA-B IFNG
26 human herpesvirus 8 10.4 HLA-A HLA-B
27 berylliosis 10.4 HLA-DRB1 IFNG
28 chronic beryllium disease 10.4 HLA-DRB1 IFNG
29 progressive bulbar palsy 10.3 HLA-A TF
30 eosinophilia-myalgia syndrome 10.3 HLA-DRB1 IFNG
31 eales disease 10.3 IFNG TF
32 campylobacteriosis 10.3 IFNG STAT1
33 microscopic colitis 10.3 HLA-DRB1 IFNG
34 central nervous system vasculitis 10.3 HLA-DRB1 IFNG
35 separation anxiety disorder 10.3 HLA-A HLA-B
36 human t-cell leukemia virus type 2 10.3 IFNG STAT1
37 aphthous stomatitis 10.3 HLA-A HLA-B
38 peanut allergy 10.3 HLA-DRB1 IFNG
39 kwashiorkor 10.2 SLC17A5 TF
40 choroiditis 10.2
41 hematopoietic stem cell transplantation 10.2 HLA-A HLA-B IFNG
42 fascioliasis 10.2 IFNG SLC17A5
43 acquired immunodeficiency syndrome 10.2
44 spondyloarthropathy 10.2 HLA-A HLA-B IFNG
45 chronic graft versus host disease 10.2 IFNG MICA
46 echinococcosis 10.2 HLA-B HLA-DRB1 IFNG
47 palindromic rheumatism 10.2 HLA-A HLA-DRB1
48 papillon-lefevre syndrome 10.2 HLA-DRB1 SLC17A5
49 rheumatic disease 10.2 HLA-B HLA-DRB1 IFNG
50 analbuminemia 10.2 SLC17A5 TF

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to Histoplasmosis

Symptoms & Phenotypes for Histoplasmosis

Symptoms:

12
  • nonproductive cough
  • headache
  • loss of appetite
  • muscle pains

UMLS symptoms related to Histoplasmosis:


pruritus, fever

GenomeRNAi Phenotypes related to Histoplasmosis according to GeneCards Suite gene sharing:

25 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.83 HLA-B HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.83 SLC17A5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.83 MICA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.83 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.83 SLC17A5
6 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.83 HLA-B HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.83 MICA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.83 SLC17A5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.83 SLC17A5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.83 SLC17A5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.83 HLA-A HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.83 HLA-A HLA-B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.83 MICA SLC17A5 HLA-A HLA-B
14 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.83 HLA-A HLA-B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.83 MICA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.83 SLC17A5
17 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.83 MICA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.83 HLA-B HLA-A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.83 HLA-A HLA-B
20 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.83 SLC17A5
21 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.83 MICA

Drugs & Therapeutics for Histoplasmosis

Drugs for Histoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Phase 3 216974-75-3
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
3
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
4 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
5 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
6 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
9 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
11 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
13 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
14
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
15
Itraconazole Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 84625-61-6 55283
16
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
17
Fluconazole Approved, Investigational Phase 3,Phase 2 86386-73-4 3365
18 Anti-Bacterial Agents Phase 3
19 Antibiotics, Antitubercular Phase 3
20 Antiparasitic Agents Phase 3
21 Antiprotozoal Agents Phase 3
22 Hydroxyitraconazole Phase 3,Phase 2,Phase 1,Early Phase 1
23 Liposomal amphotericin B Phase 3
24 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2
25 Pharmaceutical Solutions Phase 3,Early Phase 1
26
Ranibizumab Approved Phase 2,Phase 1 347396-82-1 459903
27
Verteporfin Approved, Investigational Phase 2 129497-78-5
28 Dermatologic Agents Phase 2
29 Photosensitizing Agents Phase 2
30
Ketoconazole Approved, Investigational Phase 1 65277-42-1 3823 47576
31
Petrolatum Approved, Investigational Early Phase 1 8009-03-8
32 Anti-HIV Agents

Interventional clinical trials:

(show all 27)

# Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
2 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4 Voriconazole
3 Macular Photocoagulation Study (MPS) Unknown status NCT00000158 Phase 3
4 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
5 Submacular Surgery Trials (SST) Completed NCT00000150 Phase 3
6 A Multi-center Study of Spherule-Derived Coccidioidin Completed NCT00690092 Phase 3
7 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
8 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
9 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
10 Treatment for Presumed Ocular Histoplasmosis Unknown status NCT01790893 Phase 1, Phase 2 aflibercept
11 Ranibizumab Versus PDT for Presumed Ocular Histoplasmosis Unknown status NCT00546936 Phase 2 ranibizumab;verteporfin
12 Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization in Ocular Histoplasmosis Syndrome Unknown status NCT00955630 Phase 1, Phase 2 ranibizumab;ranibizumab
13 A Study of Itraconazole in the Treatment and Prevention of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000975 Phase 2 Itraconazole
14 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
15 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
16 A Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000992 Phase 1 Itraconazole
17 A Clinical Study to Evaluate the Pharmacokinetics of Lozanoc and Sporanox in Korean Healthy Male Volunteers Completed NCT02493738 Phase 1 Lozanoc 50mg;Sporanox 100mg
18 Intravitreal Aflibercept Injection (IAI) for Presumed Ocular Histoplasmosis Syndrome Active, not recruiting NCT01578720 Phase 1 EYLEA (Aflibercept) intravitreal injection
19 Withdrawal of Antifungal Treatment for Histoplasmosis in Patients After Improved Immune Response to Anti-HIV Drugs Completed NCT00006316
20 A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients Completed NCT00002438 Itraconazole
21 Pilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00000627 Fluconazole
22 A Comparison of HIV-Infected Patients With and Without Opportunistic (AIDS-Related) Infection Completed NCT00005572
23 Topical Itraconazole in the Treatment of Basal Cell Carcinoma Recruiting NCT02120677 Early Phase 1 Itraconazole
24 Prevalence of Histoplasmosis in HIV + Patients With a Rapid Diagnostic Test in West Indies Active, not recruiting NCT01884779
25 Macugen for Histoplasmosis Terminated NCT00272766 pegaptanib sodium
26 Additive Benefit of the Urine LAM Test to Current TB Diagnostics in HIV Positive Adults in Panama City, Panama Withdrawn NCT02911740
27 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Histoplasmosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: histoplasmosis

Genetic Tests for Histoplasmosis

Anatomical Context for Histoplasmosis

MalaCards organs/tissues related to Histoplasmosis:

38
Lung, Testes, Colon, Skin, Bone, Bone Marrow, Kidney

Publications for Histoplasmosis

Articles related to Histoplasmosis:

(show top 50) (show all 803)
# Title Authors Year
1
Colonic perforation due to GI histoplasmosis in an immunocompetent host mimicking Crohn's disease. ( 29337040 )
2018
2
Concurrent<i>Pneumocystis jirovecii</i>and pulmonary histoplasmosis in an undiagnosed HIV patient. ( 29374650 )
2018
3
Gastrointestinal histoplasmosis ileal stricture successfully treated with through-the-scope balloon dilation in a patient with hyperimmunoglobulin M syndrome. ( 29340926 )
2018
4
Hemophagocytic lymphohistiocytosis in an HIV-positive patient with concomitant disseminated histoplasmosis. ( 29433397 )
2018
5
Disseminated histoplasmosis in an immunocompetent patient - utility of skin scrape cytology in diagnosis: a case report. ( 29325597 )
2018
6
PRN Ranibizumab in the Treatment of Choroidal Neovascularization Secondary to Ocular Histoplasmosis. ( 29304262 )
2018
7
Clinical signs, treatment, and prognostic factors for dogs with histoplasmosis. ( 29319442 )
2018
8
Histoplasmosis in Africa: An emerging or a neglected disease? ( 29346384 )
2018
9
Unexpected disseminated histoplasmosis detected by bone marrow biopsy in a solid organ transplant patient. ( 29375836 )
2018
10
Histoplasmosis: An oral malignancy-like clinical picture. ( 29379706 )
2018
11
Oropharyngeal histoplasmosis: The diagnosis lies in the biopsy. ( 29276680 )
2018
12
The important role of co-infections in patients with AIDS and progressive disseminated histoplasmosis (PDH): A cohort from Colombia. ( 29379705 )
2018
13
Acute Kidney Injury, Immune Thrombocytopenic Purpura, and the Infection That Binds Them Together: Disseminated Histoplasmosis. ( 29276711 )
2017
14
Tonsillar ulceration as manifestation of disseminated African histoplasmosis in an immunocompetent Portuguese host. ( 28626627 )
2017
15
Histoplasmosis in transplant recipients. ( 28805270 )
2017
16
Concomitant disseminated histoplasmosis and disseminated tuberculosis after tumor necrosis factor inhibitor treatment: a case report. ( 28086756 )
2017
17
Serious neuropsychiatric adverse effects related to interaction between itraconazole and darunavir/ritonavir in an HIV-infected patient with cerebral histoplasmosis. ( 29294026 )
2017
18
Disseminated Histoplasmosis in an Indonesian HIV-Positive Patient: A Case Diagnosed by Fine Needle Aspiration Cytology. ( 29348388 )
2017
19
Granulomatous hepatitis: a rare primary manifestation of disseminated histoplasmosis in a renal transplant recipient. ( 28617878 )
2017
20
Lower Gastrointestinal Bleeding Secondary to Intestinal Histoplasmosis in a Renal Transplant Patient. ( 28798941 )
2017
21
Opportunistic Invasive Mycoses in AIDS: Cryptococcosis, Histoplasmosis, Coccidiodomycosis, and Talaromycosis. ( 28831671 )
2017
22
Successful stepdown treatment of pulmonary histoplasmosis with thrice-weekly liposomal amphotericin B in a hospital-associated, outpatient infusion centre: A case report. ( 28806478 )
2017
23
Peripheral T-Cell Lymphoma in Mediastinum Lymph Nodes and Lung Associated to Histoplasmosis in a Patient with Chronic Lymphoid Leukemia/Small Lymphocytic Lymphoma. ( 28698787 )
2017
24
Role of Transbronchial Needle Aspiration (Conventional and EBUS Guided) in the Diagnosis of Histoplasmosis in Patients Presenting with Mediastinal Lymphadenopathy. ( 28052172 )
2017
25
Disseminated histoplasmosis presenting as multiple oral ulcers. ( 28710196 )
2017
26
Histoplasmosis hepatitis after orthotopic liver transplantation. ( 29250310 )
2017
27
Clinical Perspectives in the Diagnosis and Management of Histoplasmosis. ( 28797485 )
2017
28
Feline cutaneous histoplasmosis: The first case report from Thailand. ( 28794961 )
2017
29
African histoplasmosis: new clinical and microbiological insights. ( 28431110 )
2017
30
Hemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in systemic lupus erythematosus. ( 28786081 )
2017
31
Candidate prognostic indicators in cats with histoplasmosis treated with antifungal therapy. ( 29256743 )
2017
32
Histoplasmosis presenting as laryngeal ulcer in a post-renal transplant male: An unusual case from India. ( 28736209 )
2017
33
INTESTINAL HISTOPLASMOSIS IN A CAPTIVE REINDEER (RANGIFER TARANDUS), MISSOURI, USA. ( 28920817 )
2017
34
Primary Cutaneous Histoplasmosis Masquerading as Lepromatous Leprosy. ( 28273974 )
2017
35
Disseminated histoplasmosis in a patient with common variable immunodeficiency: A coincidence or the result of T cell defects? ( 29085780 )
2017
36
Oral manifestation of histoplasmosis on the palate. ( 29267463 )
2017
37
Demonstrating Hickam's Dictum: Metachronous Pulmonary Adenocarcinoma, Carcinoid Tumor, and Histoplasmosis. ( 28690073 )
2017
38
Histoplasmosis by Histoplasma capsulatum var. duboisii Observed at the Laboratory of Pathological Anatomy of LomAc in Togo. ( 28804654 )
2017
39
Hiding in plain sight: a case of chronic disseminated histoplasmosis with central nervous system involvement. ( 28687695 )
2017
40
Standardization and validation of real time PCR assays for the diagnosis of histoplasmosis using three molecular targets in an animal model. ( 29287097 )
2017
41
Disseminated histoplasmosis presenting as diabetic keto-acidosis in an immunocompetent patient. ( 28062431 )
2017
42
Acute Disseminated Histoplasmosis with Atypical Lymphocytosis in an Immunocompetent Host. ( 28070489 )
2017
43
Role of fine-needle aspiration cytology in diagnosis of disseminated histoplasmosis in an immunocompetent patient: A case report. ( 28701830 )
2017
44
Histoplasmosis ( 28846361 )
2017
45
Subdural Empyema in Disseminated Histoplasmosis. ( 29184348 )
2017
46
Correlation of CD4 counts with clinical and histopathological findings in disseminated histoplasmosis: a 10-year retrospective study. ( 28677260 )
2017
47
Hemophagocytic lymphohistiocytosis secondary to histoplasmosis. ( 28698842 )
2017
48
Disseminated histoplasmosis: a rare case presentation. ( 29333936 )
2017
49
High Mortality and Coinfection in a Prospective Cohort of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Patients with Histoplasmosis in Guatemala. ( 28719316 )
2017
50
Utility of antigen testing for the diagnosis of ocular histoplasmosis in four cats: a case series and literature review. ( 27527560 )
2016

Variations for Histoplasmosis

Expression for Histoplasmosis

Search GEO for disease gene expression data for Histoplasmosis.

Pathways for Histoplasmosis

Pathways related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 HLA-A HLA-B HLA-DRB1 IFNG STAT1
2
Show member pathways
12.49 HLA-A HLA-B HLA-DRB1 IFNG STAT1
3
Show member pathways
12.31 HLA-A HLA-B MICA STAT1
4
Show member pathways
12.24 HLA-A HLA-B IFNG MICA
5 12.04 HLA-A HLA-B HLA-DRB1 IFNG
6
Show member pathways
12.02 HLA-DRB1 IFNG STAT1
7 11.98 HLA-DRB1 IFNG STAT1
8 11.86 HLA-A HLA-B HLA-DRB1
9
Show member pathways
11.85 HLA-A HLA-B HLA-DRB1 IFNG STAT1
10
Show member pathways
11.84 HLA-A HLA-B HLA-DRB1 IFNG MICA STAT1
11 11.82 HLA-A HLA-B MICA
12 11.8 ATP6V1A HLA-A HLA-B HLA-DRB1
13
Show member pathways
11.77 HLA-A HLA-B IFNG STAT1
14 11.61 ATP6V1A HLA-DRB1 IFNG
15
Show member pathways
11.6 IFNG STAT1
16
Show member pathways
11.51 HLA-A HLA-DRB1 IFNG STAT1
17 11.11 HLA-B IFNG STAT1
18 11.05 HLA-DRB1 IFNG
19 11 HLA-DRB1 IFNG
20 10.93 HLA-A HLA-B

GO Terms for Histoplasmosis

Cellular components related to Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 HLA-A HLA-B HLA-DRB1 MICA TF
2 MHC class I protein complex GO:0042612 9.26 HLA-A HLA-B
3 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-A HLA-B HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-A HLA-B HLA-DRB1

Biological processes related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 HLA-A HLA-B HLA-DRB1 IFNG
2 regulation of immune response GO:0050776 9.67 HLA-A HLA-B MICA
3 defense response to virus GO:0051607 9.63 IFNG MICA STAT1
4 retina homeostasis GO:0001895 9.52 ARMS2 TF
5 transferrin transport GO:0033572 9.51 ATP6V1A TF
6 type I interferon signaling pathway GO:0060337 9.5 HLA-A HLA-B STAT1
7 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.48 HLA-A HLA-B
8 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.4 IFNG STAT1
9 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.37 HLA-A HLA-B
10 viral process GO:0016032 9.35 HLA-A HLA-B HLA-DRB1 MICA STAT1
11 antigen processing and presentation GO:0019882 9.33 HLA-A HLA-B HLA-DRB1
12 protection from natural killer cell mediated cytotoxicity GO:0042270 9.26 HLA-A HLA-B
13 interferon-gamma-mediated signaling pathway GO:0060333 9.02 HLA-A HLA-B HLA-DRB1 IFNG STAT1

Molecular functions related to Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-2-microglobulin binding GO:0030881 8.96 HLA-A MICA
2 peptide antigen binding GO:0042605 8.8 HLA-A HLA-B HLA-DRB1

Sources for Histoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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