MCID: HST011
MIFTS: 54

Histoplasmosis malady

Infectious category

Summaries for Histoplasmosis

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Histoplasmosis is a disease caused by a fungus (or mold) called histoplasma. the fungus is common in the eastern and central united states. it grows in soil and material contaminated with bat or bird droppings. you get infected by breathing the fungal spores. you cannot get the infection from someone else. histoplasmosis is often mild, with no symptoms. if you do get sick, it usually affects your lungs. symptoms include feeling ill, fever, chest pains, and a dry cough. in severe cases, histoplasmosis spreads to other organs. this is called disseminated disease. it is more common in infants, young children, seniors, and people with immune system problems. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. mild cases usually get better without treatment. treatment of severe or chronic cases is with antifungal drugs. centers for disease control and prevention

MalaCards: Histoplasmosis, also known as reticuloendotheliosis, is related to acquired immunodeficiency syndrome and coccidioidomycosis, and has symptoms including nonproductive cough, headache and loss of appetite. An important gene associated with Histoplasmosis is RP9 (retinitis pigmentosa 9 (autosomal dominant)), and among its related pathways are Immune response T cell receptor signaling pathway and Primary immunodeficiency. The drugs ketoconazole and itraconazole and the compounds pge2 and sulfolipid i have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection, has material basis in histoplasma capsulatum var capsulatum or has material basis in histoplasma capsulatum var duboisii, transmitted by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

CDC:3 Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum.  The fungus lives in the environment, usually in association with large amounts of bird or bat droppings. Lung infection can occur after a person inhales airborne, microscopic fungal spores from the environment; however, many people who inhale the spores do not get sick. The symptoms of histoplasmosis are similar to pneumonia, and the infection can sometimes become serious if it is not treated.

Wikipedia:64 Histoplasmosis (also known as \"Cave disease,\" \"Darling\'s disease,\" \"Ohio valley disease,\"... more...

Aliases & Classifications for Histoplasmosis

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 34MedlinePlus, 61UMLS, 43NIH Rare Diseases, 45Novoseek, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

histoplasmosis 8 10 49 34 61
reticuloendotheliosis 8 43 45
reticuloendotheliosis, x-linked 43 61
infection by histoplasma capsulatum 61
reticuloendothelial hyperplasia 8
darling disease 49


External Ids:

Disease Ontology8 DOID:1731
ICD9CM27 115, 115.9
NCIt40 C77201
MeSH35 D006660
MESH via Orphanet36 D006660
ICD10 via Orphanet26 B39
SNOMED-CT via Orphanet58 12962009, 76255006
UMLS via Orphanet62 C0019655, C0153261
ICD1025 B39, B39.4, B39.9

Related Diseases for Histoplasmosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1acquired immunodeficiency syndrome30.7HLA-B, CD4
2coccidioidomycosis30.5CLEC7A
3tuberculosis30.5CD4, CD79A, CLEC7A, ACPP
4nephritis30.1CD40LG, CD79A
5syphilis30.1CD4, CD79A
6arthritis30.1ACPP, CD80, CD4, HLA-B
7vasculitis30.1HLA-B, CD40LG, CD80, CD79A
8toxoplasmosis30.0CD4, CD40LG, CD79A
9systemic lupus erythematosus30.0HLA-DQA1, CD4, CD40LG, CD80, CD79A
10uveitis29.8HLA-B, CD4
11african histoplasmosis10.7
12letterer-siwe disease10.5
13blastomycosis10.5
14n syndrome10.4
15lymphangitis10.4
16american histoplasmosis10.4
17choroiditis10.4
18intrapelvic lymph node leukemic reticuloendotheliosis10.3
19paracoccidioidomycosis10.3
20histoplasmosis meningitis10.3
21histoplasmosis pericarditis10.2
22lip disease10.2
23penicilliosis10.2
24multifocal choroiditis10.2
25histoplasmosis retinitis10.2
26hypercalcemia10.2
27hairy cell leukemia of spleen10.1
28job's syndrome10.1
29pancytopenia10.1
30chronic mucocutaneous candidiasis10.1
31cryptococcosis10.1
32squamous cell carcinoma10.1
33fibrosing mediastinitis10.1
34crohn's disease10.0
35hemophagocytic lymphohistiocytosis10.0
36cellulitis10.0
37felty's syndrome10.0
38rhinosporidiosis10.0
39miliary tuberculosis10.0
40pyoderma gangrenosum10.0
41sporotrichosis10.0
42pythiosis10.0
43addison's disease10.0MICA
44purpura10.0CD79A
45dermatitis10.0CD79A
46cholangitis10.0SLC17A5
47brucellosis10.0CD79A
48leprosy10.0CD4
49myocarditis10.0CD4
50bronchiectasis10.0CD79A

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to histoplasmosis

Clinical Features for Histoplasmosis

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 4)
  • nonproductive cough
  • headache
  • loss of appetite
  • muscle pains

Drugs & Therapeutics for Histoplasmosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Histoplasmosis

Drug clinical trials:

Search ClinicalTrials for Histoplasmosis

Search NIH Clinical Center for Histoplasmosis

Search CenterWatch for Histoplasmosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Histoplasmosis

Anatomical Context for Histoplasmosis

Animal Models for Histoplasmosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Histoplasmosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.9HLA-B, HLA-DQA1, CD4, CD40LG, CD80, CD79A
2MP:00053878.4CLEC7A, TIPARP, HLA-B, HLA-DQA1, CD4, CD40LG

Publications for Histoplasmosis

Sources:
51PubMed
See all sources

Articles related to Histoplasmosis:

(show top 50)    (show all 628)
idTitleAuthorsYear
1
Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia. (23467543)
2013
2
Isolated oral histoplasmosis presenting as Fever of unknown origin in a Portuguese hemodialysis patient. (23559369)
2013
3
Acquired perforating dermatosis and Addison's disease due to disseminated histoplasmosis: Presentation and clinical outcomes. (24194970)
2013
4
A gingival manifestation of histoplasmosis leading diagnosis. (23853464)
2013
5
Disseminated histoplasmosis in HIV-infected patients in South America: a neglected killer continues on its rampage. (24278485)
2013
6
Neonatal alloimmunization: a rare case of multiple alloantibody formation in a patient with disseminated histoplasmosis. (23659530)
2013
7
Disseminated cutaneous histoplasmosis in an immunocompetent adult. (22707773)
2012
8
Histoplasmosis in India: truly uncommon or uncommonly recognised? (23777021)
2012
9
Antibody therapy for histoplasmosis. (22347215)
2012
10
Feline histoplasmosis in Brazil: clinical and laboratory aspects and a comparative approach of published reports. (22006110)
2012
11
A multicenter study of histoplasmosis and blastomycosis after solid organ transplantation. (21749587)
2012
12
Histoplasma antigen clearance during treatment of histoplasmosis in patients with AIDS determined by a quantitative antigen enzyme immunoassay. (21307278)
2011
13
Articular involvement in disseminated histoplasmosis in a kidney transplant patient taking azathioprine. (22134800)
2011
14
Lower GI bleeding from ileocolonic histoplasmosis. (21963061)
2011
15
Immune reconstitution syndrome in a patient with disseminated histoplasmosis and steroid taper: maintaining the perfect balance. (19843232)
2011
16
Disseminated histoplasmosis in a Bengal tiger (Panthera tigris). (22204071)
2011
17
Determination of the therapeutic activity of caspofungin compared with the amphotericin B in an animal experimental model of histoplasmosis in hamster (Mesocrisetus auratus). (21473926)
2011
18
Diagnosis of histoplasmosis by antigen detection in BAL fluid. (19837826)
2010
19
An outbreak of histoplasmosis among healthy young Japanese women after traveling to Southeast Asia. (20190491)
2010
20
Histoplasmosis: cytodiagnosis and review of literature with special emphasis on differential diagnosis on cytomorphology. (19843140)
2010
21
Recognition, diagnosis, and treatment of histoplasmosis complicating tumor necrosis factor blocker therapy. (19951231)
2010
22
Imported histoplasmosis: two distinct profiles in travelers and immigrants. (19674266)
2009
23
Recurrent histoplasmosis in AIDS mimicking a colonic carcinoma. (19451333)
2009
24
Severe lactic acidosis treated with prolonged hemodiafiltration in a disseminated histoplasmosis. (19092663)
2009
25
Diagnosis of acute pulmonary histoplasmosis by antigen detection. (19911965)
2009
26
Tracheal and endobronchial involvement in disseminated histoplasmosis: a case report. (19995766)
2009
27
False-positive Aspergillus galactomannan (GM) assay in histoplasmosis. (17983658)
2008
28
Histoplasmosis presenting as cellulitis 18 years after renal transplantation. (18671166)
2008
29
Histoplasmosis clinically imitating cutaneous malignancy. (18544059)
2008
30
Candida glabrata infection in gastric carcinoma patient mimicking cutaneous histoplasmosis. (18700118)
2008
31
Disseminated histoplasmosis and tuberculosis in a patient with HIV infection. (17594164)
2007
32
Penoscrotal histoplasmosis following bladder carcinoma. (17593111)
2007
33
Articular presentation of disseminated histoplasmosis. (16724167)
2007
34
Disseminated histoplasmosis in a patient with AIDS: case report and review of the literature. (18038693)
2007
35
A quick and cost-effective method for diagnosing disseminated histoplasmosis in children. (17188450)
2007
36
Disseminated histoplasmosis - comment 2. (18087105)
2007
37
Salvage treatment of histoplasmosis with posaconazole. (16824608)
2007
38
Histoplasmosis in a dog from New Brunswick. (17824159)
2007
39
Disseminated histoplasmosis: case report and brief review. (17098629)
2006
40
Detection of imported histoplasmosis in serum of HIV-infected patients using a real-time PCR-based assay. (17024507)
2006
41
Increased incidence of disseminated histoplasmosis following highly active antiretroviral therapy initiation. (16652055)
2006
42
Disseminated histoplasmosis in an immunocompetent individual--a case report. (16758666)
2005
43
Acquired immunodeficiency syndrome-related oral and/or cutaneous histoplasmosis: a descriptive and comparative study of 21 cases in French Guiana. (12358826)
2002
44
Differences in histoplasmosis in patients with acquired immunodeficiency syndrome in the United States and Brazil. (12447743)
2002
45
Fluconazole in the therapy of multiple osteomyelitis in African histoplasmosis. (10422020)
1999
46
Focal lesion of African histoplasmosis presenting as a malignant gastric ulcer. (8799429)
1996
47
Mandibular African histoplasmosis: imitation of neoplasia or giant-cell granuloma? (3422400)
1988
48
Serodiagnosis of histoplasmosis and blastomycosis. (3113302)
1987
49
Studies on histoplasmosis farciminosi (epizootic lymphangitis) in Egypt. Isolation of Histoplasma farciminosum from cases of histoplasmosis farciminosi in horses and its morphological characteristics. (3842362)
1985
50
Use of enzyme-linked immunosorbent assay for the diagnosis of equine Histoplasmosis farciminosi (epizootic lymphangitis). (4047125)
1985

Genetic Variations for Histoplasmosis

Expression for genes affiliated with Histoplasmosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Histoplasmosis

Search GEO for disease gene expression data for Histoplasmosis.

Pathways for genes affiliated with Histoplasmosis

Sources:
12EMD Millipore, 30KEGG, 54Reactome, 52QIAGEN, 38NCBI BioSystems Database
See all sources

Pathways related to Histoplasmosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0REL, CD4, HLA-DQA1
29.9CD4, CD40LG, CD79A
39.9ATP6V1A, CD80
4
Immune response ICOS pathway in T-helper cell
Hide members
9.9REL, CD80, HLA-DQA1
5
Hide members
9.8HLA-DQA1, CD4, CD80
6
Hide members
9.8REL, CD79A, MICA, HLA-B
7
Hide members
9.8CD4, CD40LG, CD79A, REL
8
Immune response NFAT in immune response
Hide members
9.7REL, CD79A, CD80, HLA-DQA1
99.7CLEC7A, ATP6V1A, HLA-DQA1, HLA-B
109.5HLA-B, HLA-DQA1, CD4, CD40LG, CD80
11
Hide members
9.5HLA-B, HLA-DQA1, CD4, CD40LG, CD80
12
Hide members
8.8REL, HLA-B, HLA-DQA1, POLR3B, MICA, CD4

Compounds for genes affiliated with Histoplasmosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Histoplasmosis according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1pge24510.6CD4
2sulfolipid i4510.5CD40LG, CD79A
3sandoglobulin4510.5CD79A, CD40LG
4hemocyanin4510.3CD79A, CD40LG, CD4
5mannan4510.3CD79A, CD40LG, CD4
6anti-fungal4510.3REL, CD79A, CD40LG
7lactulose4510.3SLC17A5, CD79A
8valproate4510.3SLC17A5, CD79A, CD40LG
9vancomycin45 1111.3CD40LG, CD79A
10ursodeoxycholic acid45 11 2412.3SLC17A5, CD40LG, HLA-B
11ribavirin45 50 1112.2SLC17A5, CD40LG, HLA-B
12vitamin b124510.2SLC17A5, CD79A, CD40LG
13carbamazepine45 50 1112.2HLA-B, CD79A, SLC17A5
14pneumococcal4510.1SLC17A5, CD79A, CD40LG, HLA-B
15tuberculin4510.1CD79A, CD40LG
16phenytoin45 50 29 1113.1SLC17A5, CD79A, CD40LG, HLA-B
17tacrolimus45 50 1112.1HLA-B, CD79A, REL, SLC17A5
18rituximab45 50 1112.1CD40LG, CD80, CD79A
19allergens4510.0CD79A, CD80, CD40LG
20mannose4510.0CD4, CD80, CD79A, CLEC7A
21blys4510.0CD79A, CD40LG
22polyethylene glycol4510.0CD40LG, CD79A, SLC17A5
23rantes4510.0HLA-B, CD4, CD40LG, REL
24polysaccharide459.8CD79A, CD40LG, CD4, HLA-B
25neopterin459.8CD4, CD40LG, CD79A, SLC17A5, ACPP
26paraffin459.8HLA-B, HLA-DQA1, CD40LG, CD79A, ACPP
27fibrinogen459.7SLC17A5, CD79A, CD40LG, HLA-B
28lactate459.7HLA-B, CD40LG, CD79A, SLC17A5, ACPP
29aspartate459.7HLA-B, HLA-DQA1, CD40LG, SLC17A5, ACPP
30creatinine459.7ACPP, SLC17A5, CD79A, CD40LG, HLA-B
31cyclosporin a45 29 6011.7HLA-B, CD40LG, CD80, CD79A, REL, SLC17A5
32dexamethasone45 50 29 1112.7HLA-B, CD40LG, CD80, CD79A, REL, CLEC7A
33testosterone45 60 11 2412.1HLA-B, CD40LG, CD79A, SLC17A5, ACPP

GO Terms for genes affiliated with Histoplasmosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Histoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomal membraneGO:0057659.5ACPP, SLC17A5, ATP6V1A, HLA-DQA1
2external side of plasma membraneGO:0098979.4CLEC7A, CD79A, CD80, CD40LG, CD4
3integral to plasma membraneGO:0058878.8HLA-B, HLA-DQA1, ATP6V1A, MICA, CD40LG, GPR22

Biological processes related to Histoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.0CD79A, CD40LG
2T cell costimulationGO:0312959.8CD80, CD4, HLA-DQA1
3positive regulation of interleukin-2 biosynthetic processGO:0450869.7CD4, CD80
4innate immune responseGO:0450879.5CLEC7A, CD80, CD4, POLR3B, HLA-B

Molecular functions related to Histoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proton-transporting ATPase activity, rotational mechanismGO:04696110.0ATP6V1A, ATP5A1

Products for genes affiliated with Histoplasmosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Histoplasmosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet