MCID: HST011
MIFTS: 65

Histoplasmosis malady

Infectious diseases category

Summaries for Histoplasmosis

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Histoplasmosis is a disease caused by a fungus (or mold) called histoplasma. the fungus is common in the eastern and central united states. it grows in soil and material contaminated with bat or bird droppings. you get infected by breathing the fungal spores. you cannot get the infection from someone else. histoplasmosis is often mild, with no symptoms. if you do get sick, it usually affects your lungs. symptoms include feeling ill, fever, chest pains, and a dry cough. in severe cases, histoplasmosis spreads to other organs. this is called disseminated disease. it is more common in infants, young children, seniors, and people with immune system problems. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. mild cases usually get better without treatment. treatment of severe or chronic cases is with antifungal drugs. centers for disease control and prevention

MalaCards: Histoplasmosis, also known as reticuloendotheliosis, is related to acquired immunodeficiency syndrome and coccidioidomycosis, and has symptoms including muscle pains, loss of appetite and nonproductive cough. An important gene associated with Histoplasmosis is RP9 (retinitis pigmentosa 9 (autosomal dominant)), and among its related pathways are Immune response T cell receptor signaling pathway and Primary immunodeficiency. The drugs ketoconazole and itraconazole and the compounds pge2 and sulfolipid i have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and colon, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A primary systemic mycosis that results in systemic fungal infection, has material basis in histoplasma capsulatum var capsulatum or has material basis in histoplasma capsulatum var duboisii, transmitted by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

CDC:3 Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum.  The fungus lives in the environment, usually in association with large amounts of bird or bat droppings. Lung infection can occur after a person inhales airborne, microscopic fungal spores from the environment; however, many people who inhale the spores do not get sick. The symptoms of histoplasmosis are similar to pneumonia, and the infection can sometimes become serious if it is not treated.

Wikipedia:63 Histoplasmosis (also known as \"Cave disease,\" \"Darling\'s disease,\" \"Ohio valley disease,\"... more...

Aliases & Classifications for Histoplasmosis

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 33MedlinePlus, 60UMLS, 42NIH Rare Diseases, 44Novoseek, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

histoplasmosis 8 10 48 33 60
reticuloendotheliosis 8 42 44
reticuloendotheliosis, x-linked 42 60
infection by histoplasma capsulatum 60
reticuloendothelial hyperplasia 8
darling disease 48


External Ids:

Disease Ontology8 DOID:1731
ICD9CM27 115, 115.9
NCIt39 C77201
MeSH34 D006660
ICD10 via Orphanet26 B39.0, B39.2, B39.3 B39.4, B39.1, B39.5, B39.9, more
MESH via Orphanet35 D006660
SNOMED-CT via Orphanet57 12962009, 76255006
UMLS via Orphanet61 C0019655, C0153261
ICD1025 B39, B39.4, B39.9

Related Diseases for Histoplasmosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1acquired immunodeficiency syndrome30.7HLA-B, CD4
2coccidioidomycosis30.4CLEC7A
3tuberculosis30.4CD4, CD79A, CLEC7A, ACPP
4addison's disease30.2MICA
5candidiasis30.1CD79A, CD4
6lung cancer30.1CD4
7lupus erythematosus30.1CD40LG, CD79A
8sarcoidosis30.1CD80, CD4
9syphilis30.1CD4, CD79A
10meningitis30.0CD79A, CD4, HLA-B
11rheumatoid arthritis30.0CD79A, CD80, CD40LG, CD4
12arthritis30.0ACPP, CD80, CD4, HLA-B
13hepatitis30.0SLC17A5, CD40LG, CD4, HLA-B
14vasculitis30.0HLA-B, CD40LG, CD80, CD79A
15leprosy29.9CD4
16inflammatory bowel disease29.9CD4, CD79A
17toxoplasmosis29.9CD4, CD40LG, CD79A
18systemic lupus erythematosus29.9HLA-DQA1, CD4, CD40LG, CD80, CD79A
19myocarditis29.7CD4
20pneumonia29.7CD4, CD79A
21uveitis29.7HLA-B, CD4
22myositis29.7HLA-B, SLC17A5
23connective tissue disease29.7CD4, CD40LG, CD79A
24hepatitis c29.7SLC17A5, CD40LG, CD4
25burkitt's lymphoma29.7HLA-B, CD4, CD40LG, CD80, CD79A, REL
26leukemia29.7HLA-B, CD4, CD40LG, CD80, CD79A, REL
27african histoplasmosis10.7
28letterer-siwe disease10.5
29choroiditis10.5
30blastomycosis10.5
31american histoplasmosis10.3
32intrapelvic lymph node leukemic reticuloendotheliosis10.3
33lymphangitis10.3
34paracoccidioidomycosis10.3
35laryngitis10.3
36mediastinitis10.3
37histoplasmosis meningitis10.2
38histoplasmosis pericarditis10.2
39penicilliosis10.2
40laryngeal carcinoma10.2
41histoplasmosis retinitis10.1
42hypercalcemia10.1
43hairy cell leukemia of spleen10.1
44hairy cell leukemia10.1
45job's syndrome10.1
46pancytopenia10.1
47chronic mucocutaneous candidiasis10.1
48cryptococcosis10.1
49chorioretinitis10.1
50interstitial nephritis10.1

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to histoplasmosis

Clinical Features for Histoplasmosis

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Sources:
8Disease Ontology
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Symptoms:

8
  • muscle pains
  • loss of appetite
  • nonproductive cough
  • headache

Drugs & Therapeutics for Histoplasmosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Histoplasmosis

Drug clinical trials:

Search ClinicalTrials for Histoplasmosis

Search NIH Clinical Center for Histoplasmosis

Search CenterWatch for Histoplasmosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Histoplasmosis

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Anatomical Context for Histoplasmosis

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32MalaCards
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MalaCards organs/tissues related to Histoplasmosis:

32
Lung, Testes, Colon, Skin, Bone, Kidney, Bone marrow, T cells, B cells, Lymph node, Tongue, Endothelial, Retina, Adrenal gland, Myeloid, Heart, Whole blood, Spleen, Prostate, Brain, Spinal cord, Liver

Animal Models for Histoplasmosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Histoplasmosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.9HLA-B, HLA-DQA1, CD4, CD40LG, CD80, CD79A
2MP:00053878.4CLEC7A, TIPARP, HLA-B, HLA-DQA1, CD4, CD40LG

Publications for Histoplasmosis

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Sources:
50PubMed
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Articles related to Histoplasmosis:

(show top 50)    (show all 628)
idTitleAuthorsYear
1
Histoplasmosis in a state where it is not known to be endemic-montana, 2012-2013. (24354878)
2014
2
Application of nested PCR for diagnosis of histoplasmosis. (23345048)
2013
3
Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis. (23541320)
2013
4
Disseminated histoplasmosis in an apparently immunocompetent individual from north India: a case report and review. (23547881)
2013
5
18F-fluorodeoxyglucose positron emission tomography for the initial evaluation and monitoring of therapeutic response in bilateral adrenal histoplasmosis. (23768741)
2013
6
Perforation of the nasal septum as the first sign of histoplasmosis associated with AIDS and review of published literature. (23661050)
2013
7
Disseminated histoplasmosis and aids: relapse and late mortality in endemic area in North-Eastern Brazil. (23496116)
2013
8
Visibility of Histoplasma within histiocytes on hematoxylin and eosin distinguishes disseminated histoplasmosis from other forms of pulmonary histoplasmosis. (24054723)
2013
9
Laryngeal histoplasmosis: an occupational hazard. (24154590)
2013
10
The mycoarray as an aid for the diagnosis of an imported case of histoplasmosis in an Italian traveler returning from Brazil. (23992579)
2013
11
Disseminated histoplasmosis and haemophagocytic syndrome in two kidney transplant patients. (23013962)
2012
12
Disseminated histoplasmosis complicating HIV infection. (23387003)
2012
13
Histoplasmosis mimicking felty syndrome. (22832303)
2012
14
Fatal histoplasmosis in a non-HIV patient in French Guiana. (23518023)
2012
15
Bilateral adrenal histoplasmosis in an immunocompetent patient. (23405541)
2012
16
Histoplasmosis on bone marrow aspirate cytological examination associated with hemophagocytosis and pancytopenia in an AIDS patient. (22479282)
2012
17
Oral histoplasmosis of a healthy man in a non-endemic area. (21735110)
2011
18
Oropharyngeal histoplasmosis: report of eleven cases and review of the literature. (21340403)
2011
19
Histoplasmosis in Australia: report of 16 cases and literature review. (21200187)
2011
20
Progressive disseminated histoplasmosis in an immunocompetent patient as an underrecognized imported mycosis in Japan. (20549287)
2010
21
Adrenal histoplasmosis. (19373915)
2010
22
Disseminated histoplasmosis presenting as granulomatous epididymo-orchitis. (19745612)
2009
23
First case report of histoplasmosis in a cat in Japan. (20046039)
2009
24
Disseminated histoplasmosis diagnosed on bone marrow aspirate cytology: report of four cases. (21591519)
2009
25
Combined therapy with amphotericin B and caspofungin in an experimental model of disseminated histoplasmosis. (19507469)
2009
26
Exuberant mucocutaneous lesions of disseminated histoplasmosis in a human immunodeficiency virus (HIV) positive patient. (19200192)
2009
27
Treating oral histoplasmosis in an immunocompetent patient. (19884394)
2009
28
A case of histoplasmosis mimicking tuberculosis. (18822647)
2008
29
Histoplasmosis: a study of 158 cases in Venezuela, 2000-2005. (18626302)
2008
30
Surgical removal vs observation for idiopathic or ocular histoplasmosis syndrome-associated subfoveal choroidal neovascularization: Vision Preference Value Scale findings from the randomized SST Group H Trial: SST Report No. 17. (19064840)
2008
31
Disseminated histoplasmosis in acquired immunodeficiency syndrome patients in Uberaba, MG, Brazil. (18254750)
2008
32
Primary mucocutaneous histoplasmosis presents as oral ulcer . (17563929)
2007
33
Ileal perforation and reactive hemophagocytic syndrome in a patient with disseminated histoplasmosis: the role of the real-time polymerase chain reaction in the diagnosis and successful treatment with amphotericin B lipid complex. (17141457)
2007
34
AIDS-related disseminated histoplasmosis in the greater Caribbean: how frequent is it? (16549988)
2006
35
Unusual orofacial manifestations of histoplasmosis in renal transplanted patient. (16482388)
2006
36
Spinal intramedullary histoplasmosis as the initial presentation of human immunodeficiency virus infection: case report. (17143208)
2006
37
An outbreak of histoplasmosis in the city of Blumenau, Santa Catarina. (17268739)
2006
38
Another case of histoplasmosis in a non-endemic area. (16916738)
2006
39
Histoplasmosis: a review for clinicians from non-endemic areas. (16784440)
2006
40
Molecular evidence of recurrent histoplasmosis with 9-year latency in a patient with Addison's disease. (16145175)
2005
41
Disseminated histoplasmosis and primary central nervous system lymphoma. (15094912)
2004
42
Panniculitis: a presenting manifestation of disseminated histoplasmosis in a patient with rheumatoid arthritis. (17041467)
2003
43
Disseminated primary cutaneous histoplasmosis successfully treated with itraconazole. (17642952)
2003
44
Study on Histoplasmosis (epizootic lymphangitis) in cart-horses in Ethiopia. (12441683)
2002
45
Testing your diagnostic skills #64. Case No 1. Squamous cell carcinoma. Histoplasmosis. Blastomycosis. (12483913)
2002
46
Itraconazole released for blastomycosis and histoplasmosis therapy. (8381341)
1993
47
Other infections of the choroid and retina. Toxoplasmosis, histoplasmosis, Lyme disease, syphilis, tuberculosis, and ocular toxocariasis. (1460269)
1992
48
African histoplasmosis manifesting as a cutaneous tumour treated with econazole. (7154150)
1982
49
Pulmonary lesions in African histoplasmosis. (5638339)
1968
50
Tropical African histoplasmosis. (13592890)
1958

Genetic Variations for Histoplasmosis

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Expression for genes affiliated with Histoplasmosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Histoplasmosis

Search GEO for disease gene expression data for Histoplasmosis.

Pathways for genes affiliated with Histoplasmosis

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12EMD Millipore, 29KEGG, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Histoplasmosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0HLA-DQA1, CD4, REL
29.9CD79A, CD40LG, CD4
39.9CD80, ATP6V1A
4
Immune response ICOS pathway in T-helper cell
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9.9REL, HLA-DQA1, CD80
5
Hide members
9.8HLA-DQA1, CD4, CD80
6
Hide members
9.8MICA, CD79A, REL, HLA-B
7
Hide members
9.8REL, CD40LG, CD4, CD79A
8
Immune response NFAT in immune response
Hide members
9.7HLA-DQA1, REL, CD79A, CD80
99.7HLA-DQA1, CLEC7A, ATP6V1A, HLA-B
109.5CD40LG, HLA-B, HLA-DQA1, CD4, CD80
11
Hide members
9.5CD80, HLA-B, HLA-DQA1, CD4, CD40LG
12
Hide members
8.8POLR3B, MICA, HLA-DQA1, CD4, CD40LG, CD80

Compounds for genes affiliated with Histoplasmosis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Histoplasmosis according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1pge24410.6CD4
2sulfolipid i4410.5CD79A, CD40LG
3sandoglobulin4410.5CD40LG, CD79A
4hemocyanin4410.3CD79A, CD4, CD40LG
5mannan4410.3CD40LG, CD79A, CD4
6anti-fungal4410.3CD40LG, REL, CD79A
7lactulose4410.3SLC17A5, CD79A
8valproate4410.3CD40LG, CD79A, SLC17A5
9vancomycin44 1111.3CD79A, CD40LG
10ursodeoxycholic acid44 11 2412.3SLC17A5, HLA-B, CD40LG
11ribavirin44 49 1112.2SLC17A5, CD40LG, HLA-B
12vitamin b124410.2SLC17A5, CD79A, CD40LG
13carbamazepine44 49 1112.2HLA-B, SLC17A5, CD79A
14pneumococcal4410.1HLA-B, CD40LG, CD79A, SLC17A5
15tuberculin4410.1CD40LG, CD79A
16phenytoin44 49 28 1113.1HLA-B, CD40LG, CD79A, SLC17A5
17tacrolimus44 49 1112.1HLA-B, CD79A, REL, SLC17A5
18rituximab44 49 1112.1CD79A, CD40LG, CD80
19allergens4410.0CD80, CD40LG, CD79A
20mannose4410.0CLEC7A, CD80, CD4, CD79A
21blys4410.0CD40LG, CD79A
22polyethylene glycol4410.0CD79A, CD40LG, SLC17A5
23rantes4410.0CD4, REL, CD40LG, HLA-B
24polysaccharide449.8CD4, CD79A, CD40LG, HLA-B
25neopterin449.8CD4, CD79A, SLC17A5, ACPP, CD40LG
26paraffin449.8ACPP, HLA-B, CD40LG, CD79A, HLA-DQA1
27fibrinogen449.7CD40LG, CD79A, HLA-B, SLC17A5
28lactate449.7ACPP, SLC17A5, CD40LG, CD79A, HLA-B
29aspartate449.7CD40LG, ACPP, SLC17A5, HLA-DQA1, HLA-B
30creatinine449.7ACPP, HLA-B, CD40LG, CD79A, SLC17A5
31cyclosporin a44 28 5911.7HLA-B, CD40LG, SLC17A5, REL, CD80, CD79A
32dexamethasone44 49 28 1112.7REL, CD79A, CD80, CD40LG, HLA-B, CLEC7A
33testosterone44 59 11 2412.1SLC17A5, HLA-B, CD40LG, CD79A, ACPP

GO Terms for genes affiliated with Histoplasmosis

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16Gene Ontology
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Cellular components related to Histoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomal membraneGO:0057659.5HLA-DQA1, ATP6V1A, SLC17A5, ACPP
2external side of plasma membraneGO:0098979.4CD4, CD40LG, CD80, CD79A, CLEC7A
3integral to plasma membraneGO:0058878.8HLA-B, HLA-DQA1, ATP6V1A, MICA, CD40LG, GPR22

Biological processes related to Histoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.0CD79A, CD40LG
2T cell costimulationGO:0312959.8CD80, CD4, HLA-DQA1
3positive regulation of interleukin-2 biosynthetic processGO:0450869.7CD4, CD80
4innate immune responseGO:0450879.5CLEC7A, CD80, CD4, POLR3B, HLA-B

Molecular functions related to Histoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proton-transporting ATPase activity, rotational mechanismGO:04696110.0ATP6V1A, ATP5A1

Products for genes affiliated with Histoplasmosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Histoplasmosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet