MCID: HST011
MIFTS: 51

Histoplasmosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Histoplasmosis

MalaCards integrated aliases for Histoplasmosis:

Name: Histoplasmosis 12 56 41 3 42 14 69
Infection by Histoplasma Capsulatum 69
Reticuloendotheliosis, X-Linked 42
Darling Disease 56

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1731
ICD10 33 B39 B39.9 B39.4
ICD9CM 35 115 115.9
Orphanet 56 ORPHA390
MESH via Orphanet 43 D006660
UMLS via Orphanet 70 C0019655 C0153261
ICD10 via Orphanet 34 B39.0 B39.1 B39.2 more

Summaries for Histoplasmosis

MedlinePlus : 41 histoplasmosis is a disease caused by a fungus (or mold) called histoplasma. the fungus is common in the eastern and central united states. it grows in soil and material contaminated with bat or bird droppings. you get infected by breathing the fungal spores. you cannot get the infection from someone else. histoplasmosis is often mild, with no symptoms. if you do get sick, it usually affects your lungs. symptoms include feeling ill, fever, chest pains, and a dry cough. in severe cases, histoplasmosis spreads to other organs. this is called disseminated disease. it is more common in infants, young children, seniors, and people with immune system problems. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. mild cases usually get better without treatment. treatment of severe or chronic cases is with antifungal drugs. centers for disease control and prevention

MalaCards based summary : Histoplasmosis, also known as infection by histoplasma capsulatum, is related to hemophagocytic lymphohistiocytosis and cryptococcosis, and has symptoms including fever and pruritus. An important gene associated with Histoplasmosis is ATP6V1A (ATPase H+ Transporting V1 Subunit A), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Bevacizumab and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and colon, and related phenotype is Increased shRNA abundance (Z-score > 2).

Disease Ontology : 12 A primary systemic mycosis that results_in systemic fungal infection, has material basis in Histoplasma capsulatum var capsulatum or has material basis in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

CDC : 3 Histoplasmosis is an infection caused by a fungus called Histoplasma. The fungus lives in the environment, particularly in soil that contains large amounts of bird or bat droppings. In the United States, Histoplasma mainly lives in the central and eastern states, especially areas around the Ohio and Mississippi River valleys. The fungus also lives in parts of Central and South America, Africa, Asia, and Australia.

Wikipedia : 72 Histoplasmosis (also known as \"Cave disease,\" \"Darling\'s disease,\" \"Ohio valley disease,\"... more...

Related Diseases for Histoplasmosis

Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
id Related Disease Score Top Affiliating Genes
1 hemophagocytic lymphohistiocytosis 30.4 HLA-A HLA-B IFNG
2 cryptococcosis 30.0 HLA-B HLA-DRB1
3 rheumatoid arthritis 28.8 HLA-B HLA-DQA1 HLA-DRB1 IFNG
4 african histoplasmosis 12.2
5 american histoplasmosis 12.2
6 histoplasmosis pericarditis 11.9
7 histoplasmosis retinitis 11.8
8 histoplasmosis meningitis 11.8
9 blastomycosis 11.1
10 fibrosing mediastinitis 11.1
11 reticuloendotheliosis 10.9
12 chronic rhinitis 10.8
13 rickets 10.8
14 autosomal recessive severe congenital neutropenia due to cxcr2 deficiency 10.7 HLA-A HLA-B
15 thelaziasis 10.7 ATP6V1A IFNG
16 cardioskeletal syndrome, kuwaiti type 10.7 HLA-A HLA-B
17 lens-induced iridocyclitis 10.6 HLA-A HLA-B
18 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.6 HLA-B IFNG
19 thrombotic thrombocytopenic purpura 10.6 HLA-A HLA-B
20 heterotaxy, visceral, 4, autosomal 10.6 HLA-A HLA-B
21 cyclosporiasis 10.5 HLA-B IFNG
22 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.5 IFNG MICA
23 compartment syndrome 10.5 HLA-A TF
24 migraine with brainstem aura 10.5 HLA-B HLA-DRB1
25 idiopathic subglottic tracheal stenosis 10.5 HLA-B HLA-DRB1
26 early-onset zonular cataract 10.5 IFNG TF
27 antigen-peptide-transporter 2 deficiency 10.5 CFH HLA-B
28 anthracosilicosis 10.4 HLA-DRB1 IFNG
29 mosaic trisomy 1 10.4 HLA-DRB1 IFNG
30 halal setton wang syndrome 10.4 CFH TF
31 fibrous histiocytoma 10.4 EGF IFNG
32 lymphocytic colitis 10.4 HLA-DRB1 IFNG
33 parametritis 10.4 CFH IFNG
34 hypertrophy of breast 10.4 HLA-A HLA-B
35 acute necrotizing encephalopathy type 1 10.3 HLA-A HLA-B IFNG
36 orbital osteomyelitis 10.3 HLA-A HLA-B IFNG
37 sezary's disease 10.3 HLA-A HLA-B IFNG
38 papillary squamous carcinoma 10.3 HLA-DRB1 IFNG
39 nasu-hakola disease 10.2 HLA-A HLA-B TF
40 noma 10.2 HLA-A HLA-B
41 disease of mental health 10.2 HLA-B HLA-DRB1 IFNG
42 respiratory system disease 10.2 HLA-B HLA-DRB1 IFNG
43 ramsay hunt syndrome i 10.2 HLA-A HLA-B HLA-DRB1
44 hernia of ovary and fallopian tube 10.2 HLA-A HLA-B HLA-DRB1
45 progressive myoclonus epilepsy 10.2 HLA-A HLA-B HLA-DRB1
46 not otherwise specified 3-mga-uria type 10.2 HLA-A HLA-B HLA-DRB1
47 aseptic meningitis 10.2 HLA-A HLA-B HLA-DRB1
48 breast hemangiopericytoma 10.2 HLA-DQA1 HLA-DRB1
49 anaerobic meningitis 10.1 HLA-A HLA-B HLA-DRB1
50 biemond syndrome 10.1 HLA-DQA1 HLA-DRB1

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to Histoplasmosis

Symptoms & Phenotypes for Histoplasmosis

UMLS symptoms related to Histoplasmosis:


fever, pruritus

GenomeRNAi Phenotypes related to Histoplasmosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.13 HLA-B HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.13 SLC17A5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.13 MICA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.13 HLA-A HLA-DQA1 HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.13 SLC17A5
6 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.13 HLA-B HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.13 HLA-DQA1 MICA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.13 SLC17A5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.13 SLC17A5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.13 SLC17A5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.13 HLA-DQA1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.13 HLA-B HLA-A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.13 HLA-B HLA-A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.13 HLA-B HLA-A HLA-DQA1 MICA SLC17A5
15 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.13 HLA-B HLA-A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-45 10.13 HLA-DQA1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.13 MICA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.13 SLC17A5
19 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.13 MICA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.13 HLA-B HLA-A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.13 HLA-DQA1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.13 HLA-B HLA-A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-78 10.13 SLC17A5
24 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.13 MICA
25 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.13 HLA-DQA1

Drugs & Therapeutics for Histoplasmosis

Drugs for Histoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Phase 3 216974-75-3
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
3
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
4 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
5 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
6 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
9 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
11 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
13 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
14
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
15
Itraconazole Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 84625-61-6 55283
16
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
17
Fluconazole Approved Phase 3,Phase 2 86386-73-4 3365
18 Anti-Bacterial Agents Phase 3
19 Antibiotics, Antitubercular Phase 3
20 Antiparasitic Agents Phase 3
21 Antiprotozoal Agents Phase 3
22 Hydroxyitraconazole Phase 3,Phase 2,Phase 1,Early Phase 1
23 Liposomal amphotericin B Phase 3
24 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2
25 Pharmaceutical Solutions Phase 3,Early Phase 1
26
Ranibizumab Approved Phase 2,Phase 1 347396-82-1 459903
27
Verteporfin Approved, Investigational Phase 2 129497-78-5
28 Dermatologic Agents Phase 2
29 Photosensitizing Agents Phase 2
30
Ketoconazole Approved, Investigational Phase 1 65277-42-1 47576 3823
31
Petrolatum Approved Early Phase 1 8009-03-8
32 Anti-HIV Agents

Interventional clinical trials:

(show all 27)

id Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
2 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4 Voriconazole
3 Macular Photocoagulation Study (MPS) Unknown status NCT00000158 Phase 3
4 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
5 Submacular Surgery Trials (SST) Completed NCT00000150 Phase 3
6 A Multi-center Study of Spherule-Derived Coccidioidin Completed NCT00690092 Phase 3
7 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
8 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
9 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
10 Treatment for Presumed Ocular Histoplasmosis Unknown status NCT01790893 Phase 1, Phase 2 aflibercept
11 Ranibizumab Versus PDT for Presumed Ocular Histoplasmosis Unknown status NCT00546936 Phase 2 ranibizumab;verteporfin
12 Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization in Ocular Histoplasmosis Syndrome Unknown status NCT00955630 Phase 1, Phase 2 ranibizumab;ranibizumab
13 A Study of Itraconazole in the Treatment and Prevention of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000975 Phase 2 Itraconazole
14 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
15 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
16 A Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000992 Phase 1 Itraconazole
17 A Clinical Study to Evaluate the Pharmacokinetics of Lozanoc and Sporanox in Korean Healthy Male Volunteers Completed NCT02493738 Phase 1 Lozanoc 50mg;Sporanox 100mg
18 Intravitreal Aflibercept Injection (IAI) for Presumed Ocular Histoplasmosis Syndrome Active, not recruiting NCT01578720 Phase 1 EYLEA (Aflibercept) intravitreal injection
19 Withdrawal of Antifungal Treatment for Histoplasmosis in Patients After Improved Immune Response to Anti-HIV Drugs Completed NCT00006316
20 A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients Completed NCT00002438 Itraconazole
21 Pilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00000627 Fluconazole
22 A Comparison of HIV-Infected Patients With and Without Opportunistic (AIDS-Related) Infection Completed NCT00005572
23 Topical Itraconazole in the Treatment of Basal Cell Carcinoma Recruiting NCT02120677 Early Phase 1 Itraconazole
24 Prevalence of Histoplasmosis in HIV + Patients With a Rapid Diagnostic Test in West Indies Active, not recruiting NCT01884779
25 Additive Benefit of the Urine LAM Test to Current TB Diagnostics in HIV Positive Adults in Panama City, Panama Not yet recruiting NCT02911740
26 Macugen for Histoplasmosis Terminated NCT00272766 pegaptanib sodium
27 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Histoplasmosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: histoplasmosis

Genetic Tests for Histoplasmosis

Anatomical Context for Histoplasmosis

MalaCards organs/tissues related to Histoplasmosis:

39
Lung, Testes, Colon, Skin, Bone, Bone Marrow, Kidney

Publications for Histoplasmosis

Articles related to Histoplasmosis:

(show top 50) (show all 780)
id Title Authors Year
1
Histoplasmosis presenting as laryngeal ulcer in a post-renal transplant male: An unusual case from India. ( 28736209 )
2017
2
Histoplasmosis ( 28846361 )
2017
3
Primary Cutaneous Histoplasmosis Masquerading as Lepromatous Leprosy. ( 28273974 )
2017
4
Role of Transbronchial Needle Aspiration (Conventional and EBUS Guided) in the Diagnosis of Histoplasmosis in Patients Presenting with Mediastinal Lymphadenopathy. ( 28052172 )
2017
5
INTESTINAL HISTOPLASMOSIS IN A CAPTIVE REINDEER (RANGIFER TARANDUS), MISSOURI, USA. ( 28920817 )
2017
6
Clinical Perspectives in the Diagnosis and Management of Histoplasmosis. ( 28797485 )
2017
7
Opportunistic Invasive Mycoses in AIDS: Cryptococcosis, Histoplasmosis, Coccidiodomycosis, and Talaromycosis. ( 28831671 )
2017
8
Granulomatous hepatitis: a rare primary manifestation of disseminated histoplasmosis in a renal transplant recipient. ( 28617878 )
2017
9
Feline cutaneous histoplasmosis: The first case report from Thailand. ( 28794961 )
2017
10
African histoplasmosis: new clinical and microbiological insights. ( 28431110 )
2017
11
Histoplasmosis by Histoplasma capsulatum var. duboisii Observed at the Laboratory of Pathological Anatomy of LomAc in Togo. ( 28804654 )
2017
12
Hemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in systemic lupus erythematosus. ( 28786081 )
2017
13
Hemophagocytic lymphohistiocytosis secondary to histoplasmosis. ( 28698842 )
2017
14
Role of fine-needle aspiration cytology in diagnosis of disseminated histoplasmosis in an immunocompetent patient: A case report. ( 28701830 )
2017
15
Peripheral T-Cell Lymphoma in Mediastinum Lymph Nodes and Lung Associated to Histoplasmosis in a Patient with Chronic Lymphoid Leukemia/Small Lymphocytic Lymphoma. ( 28698787 )
2017
16
Lower Gastrointestinal Bleeding Secondary to Intestinal Histoplasmosis in a Renal Transplant Patient. ( 28798941 )
2017
17
Acute Disseminated Histoplasmosis with Atypical Lymphocytosis in an Immunocompetent Host. ( 28070489 )
2017
18
Tonsillar ulceration as manifestation of disseminated African histoplasmosis in an immunocompetent Portuguese host. ( 28626627 )
2017
19
Histoplasmosis in transplant recipients. ( 28805270 )
2017
20
Concomitant disseminated histoplasmosis and disseminated tuberculosis after tumor necrosis factor inhibitor treatment: a case report. ( 28086756 )
2017
21
Hiding in plain sight: a case of chronic disseminated histoplasmosis with central nervous system involvement. ( 28687695 )
2017
22
Disseminated histoplasmosis presenting as diabetic keto-acidosis in an immunocompetent patient. ( 28062431 )
2017
23
Correlation of CD4 counts with clinical and histopathological findings in disseminated histoplasmosis: a 10-year retrospective study. ( 28677260 )
2017
24
Disseminated histoplasmosis presenting as multiple oral ulcers. ( 28710196 )
2017
25
High Mortality and Coinfection in a Prospective Cohort of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Patients with Histoplasmosis in Guatemala. ( 28719316 )
2017
26
Demonstrating Hickam's Dictum: Metachronous Pulmonary Adenocarcinoma, Carcinoid Tumor, and Histoplasmosis. ( 28690073 )
2017
27
Successful stepdown treatment of pulmonary histoplasmosis with thrice-weekly liposomal amphotericin B in a hospital-associated, outpatient infusion centre: A case report. ( 28806478 )
2017
28
Vertical Transmission of Histoplasmosis Associated With Anti-Tumor Necrosis Factor Therapy. ( 27012275 )
2016
29
Disseminated histoplasmosis demonstrated on F18-fluorodeoxyglucose positron emission tomography/computed tomography in a renal transplant recipient. ( 27095874 )
2016
30
Histoplasmosis-Induced Hemophagocytic Lymphohistiocytosis in an Adult Patient: A Case Report and Review of the Literature. ( 27830097 )
2016
31
Disseminated Histoplasmosis with Haemophagocytic Lymphohistiocytosis in an Immunocompetent Host. ( 27134914 )
2016
32
Blastomycosis and Histoplasmosis in a Patient with Glioblastoma Receiving Temozolomide. ( 28806010 )
2016
33
Subacute progressive disseminated histoplasmosis in immunocompetent patient. ( 26898594 )
2016
34
Utility of antigen testing for the diagnosis of ocular histoplasmosis in four cats: a case series and literature review. ( 27527560 )
2016
35
Adrenal Histoplasmosis in Immunocompetent Patients Presenting as Adrenal Insufficiency. ( 27136109 )
2016
36
Hemophagocytic Lymphohistiocytosis and Progressive Disseminated Histoplasmosis. ( 27191972 )
2016
37
Histoplasmosis. ( 26897068 )
2016
38
Childhood histoplasmosis in Colombia: Clinical and laboratory observations of 45 patients. ( 27118801 )
2016
39
Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines. ( 26976880 )
2016
40
Chronic meningitis, hydrocephalus and spinal paraplegia in non-systemic histoplasmosis. ( 27338647 )
2016
41
Intestinal histoplasmosis in immunocompetent adults. ( 27099446 )
2016
42
The Simultaneous Occurrence of Histoplasmosis and Cryptococcal Fungemia: A Case Report and Review of the Literature. ( 27423433 )
2016
43
A rare case of Addison's disease due to bilateral adrenal histoplasmosis presenting with hypoglycaemia. ( 27727656 )
2016
44
Persistent nodal histoplasmosis in nuclear factor kappa B essential modulator deficiency: Report of a case and review of infection in primary immunodeficiencies. ( 27266944 )
2016
45
Importance of multidisciplinary approach in diagnosis of histoplasmosis. ( 27438207 )
2016
46
Progressive disseminated histoplasmosis: a systematic review on the performance of non-culture-based diagnostic tests. ( 27875685 )
2016
47
Belatacept and mediastinal histoplasmosis in a kidney transplant patient. ( 27152295 )
2016
48
Sequential Chorioretinal Changes in Presumed Ocular Histoplasmosis Syndrome Analyzed Using Spectral Domain Optical Coherence Tomography. ( 27082105 )
2016
49
Unusual presentation of disseminated histoplasmosis. ( 27817934 )
2016
50
Progressive Disseminated Histoplasmosis with Coomb's Positive Hemolytic Anemia in an Immunocompetent Host. ( 27759351 )
2016

Variations for Histoplasmosis

Expression for Histoplasmosis

Search GEO for disease gene expression data for Histoplasmosis.

Pathways for Histoplasmosis

Pathways related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 25)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 ATP6V1A CFH EGF HLA-A HLA-B HLA-DQA1
2
Show member pathways
13.2 EGF HLA-A HLA-B HLA-DQA1 HLA-DRB1 MICA
3
Show member pathways
13.1 EGF HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG
4
Show member pathways
12.49 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG
5
Show member pathways
12.37 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG MICA
6
Show member pathways
12.27 HLA-A HLA-B IFNG MICA
7
Show member pathways
12.21 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG
8 12.19 HLA-A HLA-B HLA-DQA1 HLA-DRB1
9
Show member pathways
12.05 HLA-DQA1 HLA-DRB1 IFNG
10 12.02 HLA-DQA1 HLA-DRB1 IFNG
11
Show member pathways
11.94 HLA-A HLA-B IFNG
12 11.87 HLA-A HLA-B MICA
13 11.83 HLA-A HLA-B HLA-DQA1 HLA-DRB1
14
Show member pathways
11.77 HLA-A HLA-DRB1 IFNG
15 11.73 EGF HLA-DQA1 HLA-DRB1
16 11.7 EGF IFNG TF
17 11.66 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG
18
Show member pathways
11.58 HLA-DQA1 HLA-DRB1
19 11.51 ATP6V1A HLA-DQA1 HLA-DRB1 IFNG
20 11.36 CFH HLA-DQA1 HLA-DRB1
21 11.2 ATP6V1A HLA-A HLA-B HLA-DQA1 HLA-DRB1
22 11.19 HLA-B IFNG
23 11.09 HLA-DRB1 IFNG
24 11.05 HLA-DRB1 IFNG
25 10.98 HLA-A HLA-B

GO Terms for Histoplasmosis

Cellular components related to Histoplasmosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.98 ATP6V1A CFH EGF HLA-A HLA-B HLA-DRB1
2 integral component of plasma membrane GO:0005887 9.85 ATP6V1A HLA-A HLA-B HLA-DQA1 MICA SLC17A5
3 Golgi membrane GO:0000139 9.76 HLA-A HLA-B HLA-DQA1 HLA-DRB1
4 endosome membrane GO:0010008 9.65 HLA-DQA1 HLA-DRB1 TF
5 cell surface GO:0009986 9.65 HLA-A HLA-B HLA-DRB1 MICA TF
6 lysosomal membrane GO:0005765 9.55 ATP6V1A EGF HLA-DQA1 HLA-DRB1 SLC17A5
7 MHC class II protein complex GO:0042613 9.4 HLA-DQA1 HLA-DRB1
8 MHC class I protein complex GO:0042612 9.32 HLA-A HLA-B
9 ER to Golgi transport vesicle membrane GO:0012507 9.26 HLA-A HLA-B HLA-DQA1 HLA-DRB1
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.92 HLA-A HLA-B HLA-DQA1 HLA-DRB1

Biological processes related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.78 HLA-A HLA-B HLA-DQA1 HLA-DRB1
2 immune response GO:0006955 9.72 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG
3 T cell receptor signaling pathway GO:0050852 9.63 HLA-DQA1 HLA-DRB1 IFNG
4 regulation of immune response GO:0050776 9.56 HLA-A HLA-B IFNG MICA
5 transferrin transport GO:0033572 9.51 ATP6V1A TF
6 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.49 HLA-A HLA-B
7 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.43 HLA-DQA1 HLA-DRB1
8 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.4 HLA-A HLA-B
9 protection from natural killer cell mediated cytotoxicity GO:0042270 9.37 HLA-A HLA-B
10 interferon-gamma-mediated signaling pathway GO:0060333 9.35 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG
11 viral process GO:0016032 9.33 HLA-A HLA-B HLA-DRB1
12 antigen processing and presentation GO:0019882 9.02 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG

Molecular functions related to Histoplasmosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 beta-2-microglobulin binding GO:0030881 9.16 HLA-A MICA
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQA1 HLA-DRB1
3 peptide antigen binding GO:0042605 8.92 HLA-A HLA-B HLA-DQA1 HLA-DRB1

Sources for Histoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....