HIV1
MCID: HV1006
MIFTS: 64

Hiv-1 (HIV1) malady

Rare diseases category
Download this MalaCard

Summaries for Hiv-1

About this section


Fully expand this MalaCard
MalaCards based summary: Hiv-1, also known as susceptibility/resistance to hiv infection, is related to tuberculosis and aids dementia complex. An important gene associated with Hiv-1 is IL10 (interleukin 10), and among its related pathways are Akt Signaling and PAK Pathway. The compounds rantes and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include t cells, monocytes and brain, and related mouse phenotypes are immune system and hematopoietic system.

Description from OMIM:46 609423

Aliases & Classifications for Hiv-1

About this section

Hiv-1, Aliases & Descriptions:

Name: Hiv-1 30 46
Susceptibility/resistance to Hiv Infection 48
 
Hiv Type 1 46
Hiv1 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

OMIM46 609423

Related Diseases for Hiv-1

About this section

Diseases related to Hiv-1 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 260)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis31.4CXCL12, CD209, IL10
2aids dementia complex31.4CCR5, CXCL12
3encephalitis31.3TLR3, CCL2, CCR5
4syphilis31.2CCR5
5acquired immunodeficiency syndrome31.1CCR5, CXCL12, CCR2
6hepatitis c31.1TLR3, CCR5, IL10
7arthritis30.6IL10, TLR3, CCL2, CCR5
8hepatitis30.5CCL11, TLR3, CXCL12
9influenza30.1TLR3, CCR5, CCL11
10pneumonia30.0IL10, CCL11, TLR3, CCL2
11rheumatoid arthritis29.8TLR3, CXCL12, CCL2, CCR5, CCL11, IL10
12multiple sclerosis29.7TLR3, CCR5, CXCL12, CCR2, CD209, IL10
13hiv1 infection10.8
14neuronitis10.8
15endotheliitis10.7
16lupus nephritis10.7CCL2, CCR5, IL10
17periodontitis10.6CCL2, CCR5, CD209, IL10
18dementia10.6
19hiv-1 viremia10.6
20intraocular lymphoma10.6IL10
21cutaneous leishmaniasis10.6IL10, CD209
22periapical granuloma10.6CCR5, CCL2
23vaccinia10.6
24membranous glomerulonephritis10.5CCL2, CCR5
25sarcoma10.5
26kaposi's sarcoma10.5
27pulmonary sarcoidosis10.5CCR5, CCL2
28sepsis10.5CXCL12, IL10, CCL2, CCR5
29graft versus host disease10.5IL10, CXCL12, CCR5
30leukemia10.5
31uveitis10.5CCR5, IL10, CCL2, CCL11
32demyelinating disease10.4CCL2, IL10
33cork-handlers' disease10.4IL10, CCL11, CCL2, CCR5
34inflammatory bowel disease10.4CCL2, CCR5, CCL11, IL10
35psoriasis10.4IL10, CCL2, CCL11, TNIP1
36sarcoidosis10.4CCL11, CCR5, CCL2
37corneal ulcer10.4CCL11
38allergic asthma10.4IL10, CCL11, CCL2
39chronic obstructive pulmonary disease10.4CCR5, CCL11, CCL2
40neuroblastoma10.4
41atopic dermatitis10.3IL10, CCL11, CCL2
42cervicitis10.3
43ipex syndrome10.3CXCL12, TARBP1, TARBP2, KAT5, ZBTB7A, CCL2
44hepatitis b10.3
45vaginitis10.3
46herpes simplex10.3
47lipodystrophy10.3
48stomatitis10.3
49immunodeficiency with hyper igm type 210.3CD209, CXCL12, KAT5, TNIP1, CCR5, CCL11
50t-cell leukemia10.3

Graphical network of the top 20 diseases related to Hiv-1:



Diseases related to hiv-1

Symptoms for Hiv-1

About this section


Clinical features from OMIM:

609423

Drugs & Therapeutics for Hiv-1

About this section

Drug clinical trials:

Search ClinicalTrials for Hiv-1

Search NIH Clinical Center for Hiv-1

Genetic Tests for Hiv-1

About this section

Anatomical Context for Hiv-1

About this section

MalaCards organs/tissues related to Hiv-1:

32
T cells, Monocytes, Brain, Endothelial, B cells, Nk cells, Myeloid, Testes, Breast, Bone, Neutrophil, Whole blood, Liver, Cortex, Adipocyte, Lung, Placenta, Colon, Kidney, Lymph node, Thymus, Thyroid, Hypothalamus, Pituitary, Bone marrow, Spleen, Cerebellum, Spinal cord, Smooth muscle, Small intestine, Skin, Prostate, Testis, Tonsil

Animal Models for Hiv-1 or affiliated genes

About this section

MGI Mouse Phenotypes related to Hiv-1:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.2CD209, ZBTB7A, TLR3, KAT5, TNIP1, CXCL12
2MP:000539711.1TNIP1, KAT5, TLR3, ZBTB7A, CXCL12, CCR2
3MP:001076811.1ZBTB7A, TLR3, KAT5, TNIP1, CXCL12, CCR2
4MP:000200610.9TLR3, KAT5, CCR2, CCL2, CCR5, HTATIP2
5MP:000538510.8TNIP1, CXCL12, CCR2, CCL2, CCR5, IL10
6MP:000537010.8TNIP1, CXCL12, CCR2, CCL2, CCR5, IL10
7MP:000301210.7TNIP1, CXCL12, CCR2, CCR5, IL10, CD209
8MP:000538410.5KAT5, TNIP1, CXCL12, CCR2, CCL2, CCR5

Publications for Hiv-1

About this section

Articles related to Hiv-1:

(show top 50)    (show all 4993)
idTitleAuthorsYear
1
Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers. (25408842)
2014
2
HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuse. (25355898)
2014
3
Emergence of a distinct HIV-specific IL-10-producing CD8+ T-cell subset with immunomodulatory functions during chronic HIV-1 infection. (23897063)
2013
4
The HIV-1 Nef protein interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA. (22672539)
2012
5
In vitro infection of human umbilical cord blood CD34+ hematopoietic progenitor cells by HIV-1 CRF07_BC enveloped pseudovirus. (22934658)
2012
6
HIV-1 gp120 and drugs of abuse: interactions in the central nervous system. (22591361)
2012
7
Characterization of the interaction of full-length HIV-1 Vif protein with its key regulator CBFI^ and CRL5 E3 ubiquitin ligase components. (22479405)
2012
8
Elicitation of both anti HIV-1 Env humoral and cellular immunities by replicating vaccinia prime Sendai virus boost regimen and boosting by CD40Lm. (23236521)
2012
9
The genetic associations and epistatic effects of the CCR5 promoter and CCR2-V64I polymorphisms on susceptibility to HIV-1 infection in a Northern Han Chinese population. (23057571)
2012
10
CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates. (21165790)
2011
11
HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND). (21315782)
2011
12
Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3. (21360055)
2011
13
HIV-1 Nef triggers macrophage fusion in a p61Hck- and protease-dependent manner. (20488787)
2010
14
A rapid recombination assay of HIV-1 using murine CD52 as a novel biomarker. (18407776)
2008
15
HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down- regulation: analysis using short interfering RNA and knock-out mice. (18296443)
2008
16
Structure-function relationship of novel X4 HIV-1 entry inhibitors - L- and D-arginine peptide-aminoglycoside conjugates. (18028446)
2007
17
Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness. (16959283)
2007
18
Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef. (16916529)
2006
19
Molecular switch for alternative conformations of the HIV-1 V3 region: implications for phenotype conversion. (16966601)
2006
20
Transcellular protein transduction using the Tat protein of HIV-1. (15722166)
2005
21
HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses. (16001085)
2005
22
Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells. (15590971)
2004
23
MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment. (14767809)
2004
24
Activity of alpha- and theta-defensins against primary isolates of HIV-1. (15210812)
2004
25
Blockade of HIV-1 infection of New World monkey cells occurs primarily at the stage of virus entry. (12186836)
2002
26
Rescue of HIV-1 receptor function through cooperation between different forms of the CCR5 chemokine receptor. (12154092)
2002
27
Characterization of the nuclear import pathway for HIV-1 integrase. (11278458)
2001
28
Osteoblasts in HIV-infected patients: HIV-1 infection and cell function. (11698696)
2001
29
Inhibition of HIV-1 infection by down-regulation of the CXCR4 co-receptor using an intracellular single chain variable fragment against CXCR4. (11313818)
2001
30
Induction of immune responses and break of tolerance by DNA against the HIV-1 coreceptor CCR5 but no protection from SIVsm challenge. (11118363)
2000
31
Stimulating effect of HIV-1 coat protein gp120 on corticotropin-releasing hormone and arginine vasopressin in the rat hypothalamus: involvement of nitric oxide. (11085902)
2000
32
Enhancement of the basal-level activity of HIV-1 long terminal repeat by HIV-1 nucleocapsid protein. (10704334)
2000
33
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. (10620603)
2000
34
FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. (9973611)
1999
35
HIV-1 Tat protein mimicry of chemokines. (9789057)
1998
36
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. (9301668)
1997
37
In vitro chromatin assembly of the HIV-1 promoter. ATP-dependent polar repositioning of nucleosomes by Sp1 and NFkappaB. (9211915)
1997
38
Identification of the envelope V3 loop as a determinant of a CD4-negative neuronal cell tropism for HIV-1. (8610455)
1996
39
Random important alterations in HIV-1 viral quasispecies after antiviral treatment. (11324825)
1996
40
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. (8906795)
1996
41
Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion. (8659115)
1996
42
A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression. (9150887)
1996
43
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. (7716549)
1995
44
HIV-1 gp41 selectively inhibits spontaneous cell proliferation of human cell lines and mitogen- and recall antigen-induced lymphocyte proliferation. (8847089)
1995
45
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. (7588629)
1995
46
Nef protein of HIV-1 has B-cell stimulatory activity. (8086129)
1994
47
Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells. (8011246)
1994
48
Downregulation of CD28 surface antigen on CD4+ and CD8+ T lymphocytes during HIV-1 infection. (7906302)
1994
49
Antibody-dependent cellular cytotoxicity (ADCC) is directed against immunodominant epitopes of the envelope proteins of human immunodeficiency virus 1 (HIV-1). (1282012)
1992
50
Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum. (2190096)
1990

Variations for Hiv-1

About this section

Clinvar genetic disease variations for Hiv-1:

6 (show all 11)
id Gene Name Type Significance SNP ID Assembly Location
1CCL2CCL2, -2136A-Tsingle nucleotide variantPathogenic
2CCL2CCL2, 767C-Gsingle nucleotide variantPathogenic
3IL10IL10, -592C-Asingle nucleotide variantPathogenic
4TLR3NM_003265.2(TLR3): c.1234C> T (p.Leu412Phe)single nucleotide variantPathogenicrs3775291GRCh37Chr 4, 187004074: 187004074
5NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs)deletionPathogenicrs333GRCh37Chr 3, 46414947: 46414978
6NM_000579.3(CCR5): c.303T> A (p.Cys101Ter)single nucleotide variantPathogenicrs1800560GRCh37Chr 3, 46414696: 46414696
7NM_000579.3(CCR5): c.180G> T (p.Arg60Ser)single nucleotide variantPathogenicrs1800940GRCh37Chr 3, 46414573: 46414573
8CCR5CCR5, 2459A-Gsingle nucleotide variantPathogenic
9CCR2NM_001123041.2(CCR2): c.190G> A (p.Val64Ile)single nucleotide variantPathogenicrs1799864GRCh37Chr 3, 46399208: 46399208
10CCL11CCL11, -1385G-Asingle nucleotide variantPathogenic
11CXCL12NM_000609.6(CXCL12): c.266+535G> Asingle nucleotide variantPathogenicrs387906400GRCh37Chr 10, 44873550: 44873550

Expression for genes affiliated with Hiv-1

About this section
Expression patterns in normal tissues for genes affiliated with Hiv-1

Search GEO for disease gene expression data for Hiv-1.

Pathways for genes affiliated with Hiv-1

About this section

Pathways related to Hiv-1 according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.8TLR3, CXCL12, CCR2, CCL2, CCR5, CCL11
2
Show member pathways
10.8CXCL12, CCR2, CCL2, CCR5, CCL11, IL10
3
Show member pathways
10.8CXCL12, CCR2, CCL2, CCR5, CCL11, IL10
4
Show member pathways
10.8CXCL12, CCR2, CCL2, CCR5, CCL11, IL10
5
Show member pathways
10.7CXCL12, CCR2, CCL2, CCR5, CCL11
6
Show member pathways
10.7CXCL12, CCR2, CCL2, CCR5, CCL11
7
Show member pathways
10.7CCL11, CCR5, CCL2, CCR2, CXCL12
8
Show member pathways
10.7CCL11, CCR5, CCL2, CCR2, CXCL12
910.6IL10, CCR2, CXCL12
10
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
10.6TNIP1, CCL2, IL10
1110.6CCL11, CCL2

Compounds for genes affiliated with Hiv-1

About this section

Compounds related to Hiv-1 according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1rantes4411.3TLR3, CXCL12, CCL2, CCR5, CCL11, IL10
2dexamethasone44 50 28 1114.3TLR3, CXCL12, CCL2, CCR5, CCL11, IL10
3groalpha4411.2IL10, CCL11, CCR5, CCL2, CXCL12
4tarc4411.2CXCL12, CCL2, CCR5, CCL11, IL10
5ccl344 2812.2CXCL12, CCL2, CCR5, CCL11, IL10
6ly2940024411.1TLR3, CXCL12, CCL2, CCL11, IL10
7pge24411.1CXCL12, CCL2, CCR5, CCL11, IL10
8mdms4411.1IL10, CCR5, CCL2, CXCL12
9ccl444 2812.1CXCL12, CCL2, CCR5, CCL11
10zidovudine44 50 1113.1CXCL12, CCL2, CCR5, IL10
11endotoxin4411.1TLR3, CCL2, CCL11, IL10
12sdf 14411.1CXCL12, CCL2, CCR5
13mip 1alpha4411.1IL10, CCR5, CCL2
14shikonin4411.0CXCL12, CCL2, CCR5
15larc4411.0CCR5, CCL2, CXCL12
16lipoteichoic acid4411.0IL10, CCL2, TLR3
17pertussis4411.0CXCL12, CCL2, CCL11
18il 104411.0IL10, CCR5, CCL2
19sb 20358044 6112.0CXCL12, CCL2, CCL11, IL10
20tak-7792811.0CCR2, CCR5
21ccl22811.0CCR5, CCR2
22polysaccharide4411.0CD209, CCR5, CCL2, CXCL12
23peptidoglycan44 2812.0IL10, CCL11, TLR3
24histamine44 28 2413.0CCL2, CCR5, CCL11, IL10
25ccl112811.0CCR2, CCR5
26quinine44 28 2 50 1115.0CXCL12, CCR5, IL10
27ccl82811.0CCR2, CCR5
28ifn-alpha4411.0IL10, CXCL12, TLR3
29bicyclam4411.0CXCL12, CCR5
30allergens4411.0CCL11, IL10, CD209
31ccl162811.0CCR2, CCR5
32rapamycin4411.0KAT5, CXCL12, CCR5, IL10
3315-deoxy-delta-12,14-prostaglandin j24411.0CCL2, CCL11, IL10
34ccl132810.9CCR2, CCR5
35vmip-ii2810.9CCR2, CCR5
36ccl72810.9CCR2, CCR5
37tc 140126110.9CCR2, CCR5
38actinomycin d4410.8CXCL12, CCL2, CCR5, CCL11
39sb 22500261 2811.8CCR2, CCR5
40sb 2656106110.8CCR2, CCR5
41rs 5043936110.8CCR2, CCR5
42galactosylceramide4410.8CXCL12, CCR5
43grobeta4410.8CCL2, CXCL12
44maraviroc44 61 50 28 1114.7CCR5, CCR2
45toxin-14410.7IL10, CCL2
46mcp 14410.6IL10, CCL2
47cytochalasin d44 6111.6CXCL12, CCL2, CCR5
48triamcinolone acetonide44 2811.6IL10, CCR5
49herbimycin a44 6111.5CCL11, CCL2, CXCL12
50simvastatin44 50 61 28 24 1115.3IL10, CCR5, CCL2

GO Terms for genes affiliated with Hiv-1

About this section

Cellular components related to Hiv-1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.9CD209, TARBP2, RPL3, HTATIP2, CCR5, CCL2

Biological processes related to Hiv-1 according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.2IL10, CCL11, CCR5, CCL2, CCR2, TNIP1
2chemotaxisGO:00693511.1CCL11, CCR5, CCL2, CCR2, CXCL12
3chemokine-mediated signaling pathwayGO:07009811.0CXCL12, CCR2, CCL2, CCR5
4cellular calcium ion homeostasisGO:00687411.0CCL11, CCL2, CCR2, CXCL12
5viral processGO:01603211.0RPL3, HTATIP2, CCR5, CCR2, KAT5
6positive regulation of monocyte chemotaxisGO:09002610.9CXCL12, CCR2, CCR5
7viral genome replicationGO:01907910.9CD209, HTATSF1, CCL2
8positive regulation of inflammatory responseGO:05072910.9CCR2, TNIP1, TLR3
9positive regulation of endothelial cell proliferationGO:00193810.9CXCL12, CCL2, CCL11
10positive regulation of immune complex clearance by monocytes and macrophagesGO:09026510.9CCR2, CCL2
11regulation of transcription from RNA polymerase II promoterGO:00635710.9TARBP1, TARBP2, HTATSF1, HTATIP2
12cellular response to lipopolysaccharideGO:07122210.9CCL2, CCR5, IL10
13regulation of vascular endothelial growth factor productionGO:01057410.9CCL2, CCR2
14immune responseGO:00695510.8CXCL12, CCR2, CCR5, CCL11
15cellular homeostasisGO:01972510.8CCL2, CCR2
16dendritic cell chemotaxisGO:00240710.7CCR5, CCR2
17positive regulation of T cell activationGO:05087010.7CCL2, CCR2
18cellular response to interferon-gammaGO:07134610.6CCL2, TLR3
19response to activityGO:01482310.6IL10, CCL2
20response to radiationGO:00931410.6CXCL12, CCL11
21leukocyte cell-cell adhesionGO:00715910.5CD209, TNIP1
22JAK-STAT cascadeGO:00725910.3CCL2, CCR2

Molecular functions related to Hiv-1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR2 chemokine receptor bindingGO:03172710.6CCL2, CCR2
2chemokine receptor activityGO:00495010.6CCR5, CCR2
3chemokine activityGO:00800910.5CCL11, CCL2, CXCL12
4C-C chemokine receptor activityGO:01649310.3CCR5, CCR2

Products for genes affiliated with Hiv-1

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Hiv-1

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet