HIV1
MCID: HV1006
MIFTS: 61

Hiv-1 (HIV1) malady

Summaries for Hiv-1

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48OMIM, 34MalaCards
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MalaCards: Hiv-1, also known as hiv infections, is related to acquired immunodeficiency syndrome and syphilis. An important gene associated with Hiv-1 is IL10 (interleukin 10), and among its related pathways are Immune response IL 23 signaling pathway and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The drugs aldesleukin and human immunodeficiency virus nucleoside analog reverse transcriptase inhibitor [epc] and the compounds groalpha and tarc have been mentioned in the context of this disorder. Affiliated tissues include t cells, monocytes and brain, and related mouse phenotypes are immune system and hematopoietic system.

Description from OMIM:48 609423

Aliases & Classifications for Hiv-1

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48OMIM, 63UMLS
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Aliases & Descriptions:

hiv-1 48
hiv infections 63
hiv type 1 48
hiv1 48


Related Diseases for Hiv-1

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Hiv-1:



Diseases related to hiv-1

Symptoms for Hiv-1

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48OMIM
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Clinical features from OMIM:

609423

Drugs & Therapeutics for Hiv-1

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Hiv-1

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Anatomical Context for Hiv-1

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34MalaCards
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MalaCards organs/tissues related to Hiv-1:

34
T cells, Monocytes, Brain, Endothelial, B cells, Nk cells, Myeloid, Breast, Testes, Liver, Bone, Whole blood, Adipocyte, Lung, Cortex, Placenta, Colon, Kidney, Hypothalamus, Prostate, Pituitary, Lymph node, Thyroid, Thymus, Spleen, Cerebellum, Spinal cord, Small intestine, Tonsil, Skin, Testis

Animal Models for Hiv-1 or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hiv-1:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6CD209, ZBTB7A, KAT5, TNIP1, CCL2, CCR5
2MP:000539710.5KAT5, TNIP1, CCL2, CCR5, CCL11, IL10
3MP:000200610.4KAT5, CCL2, CCR5, HTATIP2, IL10
4MP:001076810.3ZBTB7A, KAT5, TNIP1, VPRBP, CCL2, CCR5

Publications for Hiv-1

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53PubMed
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Articles related to Hiv-1:

(show top 50)    (show all 4882)
idTitleAuthorsYear
1
The HIV-1 Nef protein interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA. (22672539)
2012
2
In vitro infection of human umbilical cord blood CD34+ hematopoietic progenitor cells by HIV-1 CRF07_BC enveloped pseudovirus. (22934658)
2012
3
HIV-1 gp120 and drugs of abuse: interactions in the central nervous system. (22591361)
2012
4
Characterization of the interaction of full-length HIV-1 Vif protein with its key regulator CBFI^ and CRL5 E3 ubiquitin ligase components. (22479405)
2012
5
Elicitation of both anti HIV-1 Env humoral and cellular immunities by replicating vaccinia prime Sendai virus boost regimen and boosting by CD40Lm. (23236521)
2012
6
The genetic associations and epistatic effects of the CCR5 promoter and CCR2-V64I polymorphisms on susceptibility to HIV-1 infection in a Northern Han Chinese population. (23057571)
2012
7
HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin. (22222210)
2012
8
CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates. (21165790)
2011
9
HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND). (21315782)
2011
10
Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3. (21360055)
2011
11
HIV-1 Nef triggers macrophage fusion in a p61Hck- and protease-dependent manner. (20488787)
2010
12
A rapid recombination assay of HIV-1 using murine CD52 as a novel biomarker. (18407776)
2008
13
HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down- regulation: analysis using short interfering RNA and knock-out mice. (18296443)
2008
14
Structure-function relationship of novel X4 HIV-1 entry inhibitors - L- and D-arginine peptide-aminoglycoside conjugates. (18028446)
2007
15
Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness. (16959283)
2007
16
Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef. (16916529)
2006
17
Molecular switch for alternative conformations of the HIV-1 V3 region: implications for phenotype conversion. (16966601)
2006
18
Transcellular protein transduction using the Tat protein of HIV-1. (15722166)
2005
19
HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses. (16001085)
2005
20
Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26). (15695814)
2005
21
Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells. (15590971)
2004
22
MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment. (14767809)
2004
23
Activity of alpha- and theta-defensins against primary isolates of HIV-1. (15210812)
2004
24
Blockade of HIV-1 infection of New World monkey cells occurs primarily at the stage of virus entry. (12186836)
2002
25
Rescue of HIV-1 receptor function through cooperation between different forms of the CCR5 chemokine receptor. (12154092)
2002
26
Characterization of the nuclear import pathway for HIV-1 integrase. (11278458)
2001
27
Osteoblasts in HIV-infected patients: HIV-1 infection and cell function. (11698696)
2001
28
Inhibition of HIV-1 infection by down-regulation of the CXCR4 co-receptor using an intracellular single chain variable fragment against CXCR4. (11313818)
2001
29
Induction of immune responses and break of tolerance by DNA against the HIV-1 coreceptor CCR5 but no protection from SIVsm challenge. (11118363)
2000
30
Stimulating effect of HIV-1 coat protein gp120 on corticotropin-releasing hormone and arginine vasopressin in the rat hypothalamus: involvement of nitric oxide. (11085902)
2000
31
Enhancement of the basal-level activity of HIV-1 long terminal repeat by HIV-1 nucleocapsid protein. (10704334)
2000
32
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. (10620603)
2000
33
FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. (9973611)
1999
34
HIV-1 Tat protein mimicry of chemokines. (9789057)
1998
35
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. (9301668)
1997
36
In vitro chromatin assembly of the HIV-1 promoter. ATP-dependent polar repositioning of nucleosomes by Sp1 and NFkappaB. (9211915)
1997
37
Identification of the envelope V3 loop as a determinant of a CD4-negative neuronal cell tropism for HIV-1. (8610455)
1996
38
Random important alterations in HIV-1 viral quasispecies after antiviral treatment. (11324825)
1996
39
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. (8906795)
1996
40
Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion. (8659115)
1996
41
A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression. (9150887)
1996
42
Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. (8612235)
1996
43
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. (7716549)
1995
44
HIV-1 gp41 selectively inhibits spontaneous cell proliferation of human cell lines and mitogen- and recall antigen-induced lymphocyte proliferation. (8847089)
1995
45
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. (7588629)
1995
46
Nef protein of HIV-1 has B-cell stimulatory activity. (8086129)
1994
47
Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells. (8011246)
1994
48
Downregulation of CD28 surface antigen on CD4+ and CD8+ T lymphocytes during HIV-1 infection. (7906302)
1994
49
Antibody-dependent cellular cytotoxicity (ADCC) is directed against immunodominant epitopes of the envelope proteins of human immunodeficiency virus 1 (HIV-1). (1282012)
1992
50
Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum. (2190096)
1990

Variations for Hiv-1

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Expression for genes affiliated with Hiv-1

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hiv-1

Search GEO for disease gene expression data for Hiv-1.

Pathways for genes affiliated with Hiv-1

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51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN, 55R&D Systems, 56Reactome
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Pathways related to Hiv-1 according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
10.5IL10, CCL2, TNIP1
2
Show member pathways
10.5CCL11, CCR5, CCL2
310.5CCL11, CCL2

Compounds for genes affiliated with Hiv-1

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46Novoseek, 30IUPHAR, 25HMDB, 52PharmGKB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Hiv-1 according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1groalpha4610.9IL10, CCL11, CCR5, CCL2
2tarc4610.9CCL2, CCR5, CCL11, IL10
3rantes4610.9CCL2, CCR5, CCL11, IL10, CD209
4ccl346 3011.9CCL2, CCR5, CCL11, IL10
5mip 1alpha4610.9IL10, CCR5, CCL2
6histamine46 30 2512.9CCL2, CCR5, CCL11, IL10, AGFG1
7mdms4610.9CCL2, CCR5, IL10
8il 104610.9IL10, CCR5, CCL2
9ccl446 3011.9CCL2, CCR5, CCL11
10dexamethasone46 52 30 1213.9CCL2, CCR5, CCL11, IL10, CD209
11allergens4610.9CCL11, IL10, CD209
1215-deoxy-delta-12,14-prostaglandin j24610.8CCL2, CCL11, IL10
13sdf 14610.8CCR5, CCL2
14zidovudine46 52 1212.8CCL2, CCR5, IL10
15toxin-14610.8IL10, CCL2
16mcp 14610.8IL10, CCL2
17pge24610.8CCL2, CCR5, CCL11, IL10
18shikonin4610.8CCL2, CCR5
19pamidronate46 52 1212.8AGFG1, IL10
20larc4610.7CCR5, CCL2
21simvastatin46 52 62 30 25 1215.7CCL2, CCR5, IL10
22triamcinolone acetonide46 3011.7IL10, CCR5
235 aminosalicylic acid4610.7CCL2, IL10
24il-124610.7CCL2, IL10
25endotoxin4610.6IL10, CCL11, CCL2
26geranylgeranyl pyrophosphate4610.6CCL2, AGFG1
27polymyxin b4610.5IL10, CCL2
28montelukast46 52 30 1213.5IL10, CCL11
29heroin46 52 1212.4IL10, CCL2
30guanine46 25 1212.2CCR5, IL10, AGFG1

GO Terms for genes affiliated with Hiv-1

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17Gene Ontology
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Cellular components related to Hiv-1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.5ZBTB7A, TARBP2, KRR1, RPL3, HTATSF1, HTATIP2
2cytoplasmGO:00573710.2TNIP1, TARBP2, KRR1, RPL3, HTATIP2, CCT7

Biological processes related to Hiv-1 according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695410.7CCR5, TNIP1, IL10, CCL11, CCL2
2viral genome replicationGO:01907910.7CD209, CCL2, HTATSF1
3viral processGO:01603210.7VPRBP, CCR5, HTATIP2, RPL3, KAT5
4cellular response to lipopolysaccharideGO:07122210.7IL10, CCR5, CCL2
5regulation of transcription from RNA polymerase II promoterGO:00635710.6TARBP1, TARBP2, HTATSF1, HTATIP2
6chemotaxisGO:00693510.6CCL2, CCR5, CCL11
7leukocyte cell-cell adhesionGO:00715910.5CD209, TNIP1
8regulation of ARF GTPase activityGO:03231210.5AGFG1, AGFG2
9chemokine-mediated signaling pathwayGO:07009810.4CCR5, CCL2
10response to activityGO:01482310.2IL10, CCL2

Molecular functions related to Hiv-1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ARF GTPase activator activityGO:00806010.5AGFG1, AGFG2

Products for genes affiliated with Hiv-1

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Sources for Hiv-1

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet