MCID: HV1006

Hiv-1 (HIV1) malady

Rare diseases category

Summaries for Hiv-1

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OMIM:46 The pathogenesis of HIV infection and the progression from infection to AIDS vary significantly between exposed... (609423) more...

MalaCards based summary: Hiv-1, also known as susceptibility/resistance to hiv infection, is related to aids dementia complex and tuberculosis. An important gene associated with Hiv-1 is IL10 (interleukin 10), and among its related pathways are Akt Signaling and PAK Pathway. The compounds rantes and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include t cells, monocytes and brain, and related mouse phenotypes are immune system and mortality/aging.

Aliases & Classifications for Hiv-1

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Hiv-1, Aliases & Descriptions:

Name: Hiv-1 31 46
Susceptibility/resistance to Hiv Infection 48
Hiv Type 1 46
Hiv1 46


Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases

External Ids:

OMIM46 609423

Related Diseases for Hiv-1

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Diseases related to Hiv-1 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 260)
idRelated DiseaseScoreTop Affiliating Genes
1aids dementia complex31.3CCR5, CXCL12
2tuberculosis31.3CXCL12, IL10, CD209
4encephalitis31.1CCR5, CCL2, TLR3
5acquired immunodeficiency syndrome31.0CCR5, CCR2, CXCL12
6hepatitis c30.9TLR3, CCR5, IL10
7arthritis30.4IL10, CCR5, CCL2, TLR3
8hepatitis30.2TLR3, CXCL12, CCL11
9influenza29.9CCL11, CCR5, TLR3
10pneumonia29.8TLR3, CCL2, CCL11, IL10
11rheumatoid arthritis29.5TLR3, CXCL12, CCL2, CCR5, CCL11, IL10
12multiple sclerosis29.4TLR3, CXCL12, CCR2, CCL2, CCR5, CCL11
13hiv1 infection10.8
16lupus nephritis10.7IL10, CCR5, CCL2
18periodontitis10.6CD209, IL10, CCR5, CCL2
19hiv-1 viremia10.6
20intraocular lymphoma10.6IL10
21cutaneous leishmaniasis10.6IL10, CD209
23periapical granuloma10.5CCR5, CCL2
24membranous glomerulonephritis10.5CCR5, CCL2
26kaposi's sarcoma10.5
27pulmonary sarcoidosis10.5CCR5, CCL2
29demyelinating disease10.4IL10, CCL2
30sepsis10.4CXCL12, CCL2, CCR5, IL10
31graft versus host disease10.4CXCL12, CCR5, IL10
32uveitis10.4CCL2, CCR5, CCL11, IL10
33cork-handlers' disease10.4IL10, CCL11, CCR5, CCL2
34inflammatory bowel disease10.4IL10, CCL11, CCR5, CCL2
35psoriasis10.4IL10, CCL11, CCL2, TNIP1
37sarcoidosis10.3CCL2, CCR5, CCL11
39corneal ulcer10.3CCL11
40allergic asthma10.3IL10, CCL11, CCL2
41hepatitis b10.3
43chronic obstructive pulmonary disease10.3CCL2, CCR5, CCL11
44atopic dermatitis10.3CCL2, CCL11, IL10
45herpes simplex10.3
48t-cell leukemia10.3
50bacterial vaginosis10.2

Graphical network of the top 20 diseases related to Hiv-1:

Diseases related to hiv-1

Symptoms for Hiv-1

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Clinical features from OMIM:


Drugs & Therapeutics for Hiv-1

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Drug clinical trials:

Search ClinicalTrials for Hiv-1

Search NIH Clinical Center for Hiv-1

Genetic Tests for Hiv-1

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Anatomical Context for Hiv-1

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MalaCards organs/tissues related to Hiv-1:

T cells, Monocytes, Brain, Endothelial, B cells, Nk cells, Myeloid, Testes, Breast, Bone, Neutrophil, Whole blood, Liver, Cortex, Adipocyte, Lung, Placenta, Colon, Kidney, Lymph node, Thymus, Thyroid, Hypothalamus, Pituitary, Bone marrow, Spleen, Cerebellum, Spinal cord, Smooth muscle, Small intestine, Skin, Prostate, Testis, Tonsil

Animal Models for Hiv-1 or affiliated genes

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MGI Mouse Phenotypes related to Hiv-1:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.1CD209, ZBTB7A, TLR3, KAT5, TNIP1, CXCL12
2MP:001076811.1VPRBP, TNIP1, KAT5, TLR3, ZBTB7A, CXCL12
3MP:000539711.0ZBTB7A, TLR3, KAT5, TNIP1, CXCL12, CCR2
4MP:000538410.8KAT5, TNIP1, VPRBP, CXCL12, CCR2, CCL2
5MP:000200610.8TLR3, KAT5, CCR2, CCL2, CCR5, HTATIP2
6MP:000538510.8TNIP1, CXCL12, CCR2, CCL2, CCR5, IL10
7MP:000537010.6TNIP1, CXCL12, CCR2, CCL2, CCR5, IL10
8MP:000301210.4TNIP1, CXCL12, CCR2, CCR5, IL10, CD209

Publications for Hiv-1

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Articles related to Hiv-1:

(show top 50)    (show all 4993)
Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers. (25408842)
HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuse. (25355898)
Emergence of a distinct HIV-specific IL-10-producing CD8+ T-cell subset with immunomodulatory functions during chronic HIV-1 infection. (23897063)
The HIV-1 Nef protein interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA. (22672539)
In vitro infection of human umbilical cord blood CD34+ hematopoietic progenitor cells by HIV-1 CRF07_BC enveloped pseudovirus. (22934658)
HIV-1 gp120 and drugs of abuse: interactions in the central nervous system. (22591361)
Characterization of the interaction of full-length HIV-1 Vif protein with its key regulator CBFI^ and CRL5 E3 ubiquitin ligase components. (22479405)
Elicitation of both anti HIV-1 Env humoral and cellular immunities by replicating vaccinia prime Sendai virus boost regimen and boosting by CD40Lm. (23236521)
The genetic associations and epistatic effects of the CCR5 promoter and CCR2-V64I polymorphisms on susceptibility to HIV-1 infection in a Northern Han Chinese population. (23057571)
CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates. (21165790)
HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND). (21315782)
Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3. (21360055)
HIV-1 Nef triggers macrophage fusion in a p61Hck- and protease-dependent manner. (20488787)
A rapid recombination assay of HIV-1 using murine CD52 as a novel biomarker. (18407776)
HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down- regulation: analysis using short interfering RNA and knock-out mice. (18296443)
Structure-function relationship of novel X4 HIV-1 entry inhibitors - L- and D-arginine peptide-aminoglycoside conjugates. (18028446)
Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness. (16959283)
Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef. (16916529)
Molecular switch for alternative conformations of the HIV-1 V3 region: implications for phenotype conversion. (16966601)
Transcellular protein transduction using the Tat protein of HIV-1. (15722166)
HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses. (16001085)
Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells. (15590971)
MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment. (14767809)
Activity of alpha- and theta-defensins against primary isolates of HIV-1. (15210812)
Blockade of HIV-1 infection of New World monkey cells occurs primarily at the stage of virus entry. (12186836)
Rescue of HIV-1 receptor function through cooperation between different forms of the CCR5 chemokine receptor. (12154092)
Characterization of the nuclear import pathway for HIV-1 integrase. (11278458)
Osteoblasts in HIV-infected patients: HIV-1 infection and cell function. (11698696)
Inhibition of HIV-1 infection by down-regulation of the CXCR4 co-receptor using an intracellular single chain variable fragment against CXCR4. (11313818)
Induction of immune responses and break of tolerance by DNA against the HIV-1 coreceptor CCR5 but no protection from SIVsm challenge. (11118363)
Stimulating effect of HIV-1 coat protein gp120 on corticotropin-releasing hormone and arginine vasopressin in the rat hypothalamus: involvement of nitric oxide. (11085902)
Enhancement of the basal-level activity of HIV-1 long terminal repeat by HIV-1 nucleocapsid protein. (10704334)
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. (10620603)
FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. (9973611)
HIV-1 Tat protein mimicry of chemokines. (9789057)
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. (9301668)
In vitro chromatin assembly of the HIV-1 promoter. ATP-dependent polar repositioning of nucleosomes by Sp1 and NFkappaB. (9211915)
Identification of the envelope V3 loop as a determinant of a CD4-negative neuronal cell tropism for HIV-1. (8610455)
Random important alterations in HIV-1 viral quasispecies after antiviral treatment. (11324825)
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. (8906795)
Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion. (8659115)
A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression. (9150887)
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. (7716549)
HIV-1 gp41 selectively inhibits spontaneous cell proliferation of human cell lines and mitogen- and recall antigen-induced lymphocyte proliferation. (8847089)
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. (7588629)
Nef protein of HIV-1 has B-cell stimulatory activity. (8086129)
Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells. (8011246)
Downregulation of CD28 surface antigen on CD4+ and CD8+ T lymphocytes during HIV-1 infection. (7906302)
Antibody-dependent cellular cytotoxicity (ADCC) is directed against immunodominant epitopes of the envelope proteins of human immunodeficiency virus 1 (HIV-1). (1282012)
Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum. (2190096)

Variations for Hiv-1

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Clinvar genetic disease variations for Hiv-1:

7 (show all 11)
id Gene Name Type Significance SNP ID Assembly Location
1CCL2CCL2, -2136A-Tsingle nucleotide variantPathogenic
2CCL2CCL2, 767C-Gsingle nucleotide variantPathogenic
3IL10IL10, -592C-Asingle nucleotide variantPathogenic, risk factor
4TLR3NM_003265.2(TLR3): c.1234C> T (p.Leu412Phe)single nucleotide variantPathogenicrs3775291GRCh37Chr 4, 187004074: 187004074
5NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs)deletionPathogenic, risk factorrs333GRCh37Chr 3, 46414947: 46414978
6NM_000579.3(CCR5): c.303T> A (p.Cys101Ter)single nucleotide variantPathogenicrs1800560GRCh37Chr 3, 46414696: 46414696
7NM_000579.3(CCR5): c.180G> T (p.Arg60Ser)single nucleotide variantPathogenicrs1800940GRCh37Chr 3, 46414573: 46414573
8CCR5CCR5, 2459A-Gsingle nucleotide variantPathogenic
9CCR2NM_001123041.2(CCR2): c.190G> A (p.Val64Ile)single nucleotide variantPathogenicrs1799864GRCh37Chr 3, 46399208: 46399208
10CCL11CCL11, -1385G-Asingle nucleotide variantPathogenic
11CXCL12NM_000609.6(CXCL12): c.266+535G> Asingle nucleotide variantPathogenicrs387906400GRCh37Chr 10, 44873550: 44873550

Expression for genes affiliated with Hiv-1

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2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Hiv-1 patients vs. healthy controls: 31 (show all 278)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1RBM25RNA binding motif protein 25Blood-4.350.000
2UBXN4UBX domain protein 4Blood-4.250.000
3LUC7L3LUC7-like 3 (S. cerevisiae)Blood-4.070.000
4DKC1dyskeratosis congenita 1, dyskerinBlood-4.000.000
5SYNCRIPsynaptotagmin binding, cytoplasmic RNA interacting proteinBlood-3.790.000
6AP3D1adaptor-related protein complex 3, delta 1 subunitBlood-3.770.000
7SRRM2serine/arginine repetitive matrix 2Blood-3.740.000
8SONSON DNA binding proteinBlood-3.730.000
9PTPRCprotein tyrosine phosphatase, receptor type, CBlood-3.670.000
10NKTRnatural killer cell triggering receptorBlood-3.570.000
11ESF1ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)Blood-3.530.000
12RBL2retinoblastoma-like 2Blood-3.490.000
13ADAM28ADAM metallopeptidase domain 28Blood-3.480.000
14PNISRPNN-interacting serine/arginine-rich proteinBlood-3.440.000
15HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 1Blood-3.380.000
16SCAF11SR-related CTD-associated factor 11Blood-3.360.000
17NBPF10neuroblastoma breakpoint family, member 10Blood-3.350.000
18PRRC2Cproline-rich coiled-coil 2CBlood-3.320.000
19LRRN3leucine rich repeat neuronal 3Blood-3.280.000
20PPIGpeptidylprolyl isomerase G (cyclophilin G)Blood-3.270.000
21IFI27interferon, alpha-inducible protein 27Blood+3.250.000
22TRIM23tripartite motif containing 23Blood-3.230.000
23ANKRD12ankyrin repeat domain 12Blood-3.220.000
24CHD4chromodomain helicase DNA binding protein 4Blood-3.120.000
25TNFAIP2tumor necrosis factor, alpha-induced protein 2Blood-3.110.000
26PTMAprothymosin, alphaBlood-3.100.000
27USO1USO1 vesicle transport factorBlood-3.090.000
28ATRXalpha thalassemia/mental retardation syndrome X-linkedBlood-3.060.000
29PRMT2protein arginine methyltransferase 2Blood-3.040.000
30TBL1Xtransducin (beta)-like 1X-linkedBlood-3.030.000
31DYRK2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2Blood-2.980.000
32SART3squamous cell carcinoma antigen recognized by T cells 3Blood-2.980.000
33HSP90B1heat shock protein 90kDa beta (Grp94), member 1Blood-2.950.000
34SF1splicing factor 1Blood-2.940.001
35LYSTlysosomal trafficking regulatorBlood-2.920.000
36PRPF40APRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)Blood-2.910.000
37PPP1R10protein phosphatase 1, regulatory subunit 10Blood-2.900.000
38EPRSglutamyl-prolyl-tRNA synthetaseBlood-2.900.000
39SLC25A36solute carrier family 25 (pyrimidine nucleotide carrier ), member 36Blood-2.900.000
40UGCGUDP-glucose ceramide glucosyltransferaseBlood-2.880.000
41SRPK2SRSF protein kinase 2Blood-2.870.000
42CEP57centrosomal protein 57kDaBlood-2.870.000
43EIF5Beukaryotic translation initiation factor 5BBlood-2.860.000
44PLEKHG3pleckstrin homology domain containing, family G (with RhoGef domain) member 3Blood-2.840.000
45PKN2protein kinase N2Blood-2.840.001
46PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1Blood-2.830.000
47TXNIPthioredoxin interacting proteinBlood-2.820.001
48ZNF573zinc finger protein 573Blood-2.810.000
49ZC3H7Bzinc finger CCCH-type containing 7BBlood-2.770.000
50TDGthymine-DNA glycosylaseBlood-2.770.000
51ANKRD11ankyrin repeat domain 11Blood-2.770.000
52IL7Rinterleukin 7 receptorBlood-2.770.000
53TRA2Btransformer 2 beta homolog (Drosophila)Blood-2.770.000
54TPRtranslocated promoter region, nuclear basket proteinBlood-2.760.000
55SP110SP110 nuclear body proteinBlood-2.750.003
56FOXO1forkhead box O1Blood-2.720.000
57SSRP1structure specific recognition protein 1Blood-2.710.000
58BRD4bromodomain containing 4Blood-2.700.000
59BTBD18BTB (POZ) domain containing 18Blood-2.700.000
60ZC3H15zinc finger CCCH-type containing 15Blood-2.700.000
61MBD4methyl-CpG binding domain protein 4Blood-2.680.000
62TOP1topoisomerase (DNA) IBlood-2.670.000
64KIF5Ckinesin family member 5CBlood-2.650.000
65IL6Rinterleukin 6 receptorBlood-2.650.000
66DHX9DEAH (Asp-Glu-Ala-His) box helicase 9Blood-2.650.000
67IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)Blood-2.640.000
68DDX24DEAD (Asp-Glu-Ala-Asp) box helicase 24Blood-2.640.000
69ZNF22zinc finger protein 22Blood-2.640.000
70EID1EP300 interacting inhibitor of differentiation 1Blood-2.620.001
71SRP72signal recognition particle 72kDaBlood-2.610.000
72LOC202181SUMO-interacting motifs containing 1 pseudogeneBlood-2.610.000
73N4BP2L2NEDD4 binding protein 2-like 2Blood-2.600.000
74TCF25transcription factor 25 (basic helix-loop-helix)Blood-2.600.000
75TAOK1TAO kinase 1Blood-2.600.000
76ZMYM2zinc finger, MYM-type 2Blood-2.590.001
77ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1Blood-2.590.000
78CFDP1craniofacial development protein 1Blood-2.590.000
79NFAT5nuclear factor of activated T-cells 5, tonicity-responsiveBlood-2.590.002
80SF3B1splicing factor 3b, subunit 1, 155kDaBlood-2.580.001
81BPTFbromodomain PHD finger transcription factorBlood-2.570.000
82LIASlipoic acid synthetaseBlood-2.570.000
83ANKRD36Bankyrin repeat domain 36BBlood-2.560.001
84HSPD1heat shock 60kDa protein 1 (chaperonin)Blood-2.550.001
85PDE4Cphosphodiesterase 4C, cAMP-specificBlood-2.550.000
86SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1Blood-2.540.000
88GPATCH8G patch domain containing 8Blood-2.540.000
89SEC14L1SEC14-like 1 (S. cerevisiae)Blood-2.520.000
90PYGBphosphorylase, glycogen; brainBlood-2.510.000
91GPR88G protein-coupled receptor 88Brain-2.510.000
92AKAP13A kinase (PRKA) anchor protein 13Blood-2.510.000
93TTC3tetratricopeptide repeat domain 3Blood-2.500.001
94LTBP3latent transforming growth factor beta binding protein 3Blood-2.480.000
95RSL1D1ribosomal L1 domain containing 1Blood-2.470.000
96INADLInaD-like (Drosophila)Blood-2.470.000
97KLF6Kruppel-like factor 6Blood-2.460.006
98SRSF10serine/arginine-rich splicing factor 10Blood-2.460.001
99PRPF6pre-mRNA processing factor 6Blood-2.460.000
100LEF1lymphoid enhancer-binding factor 1Blood-2.450.000
101ZNF654zinc finger protein 654Blood-2.440.001
102STAG3L1stromal antigen 3-like 1 (pseudogene)Blood-2.440.000
103MED1mediator complex subunit 1Blood-2.440.003
104ANO3anoctamin 3Brain-2.440.000
105PDE10Aphosphodiesterase 10ABrain-2.430.000
106HSPH1heat shock 105kDa/110kDa protein 1Blood-2.430.000
107SNRKSNF related kinaseBlood-2.420.001
108GOLGA4golgin A4Blood-2.420.001
109IFI44Linterferon-induced protein 44-likeBlood+2.420.001
110LPIN1lipin 1Blood-2.400.000
111TMEM63Atransmembrane protein 63ABlood-2.400.001
112BICD2bicaudal D homolog 2 (Drosophila)Blood-2.400.005
113CYP1B1cytochrome P450, family 1, subfamily B, polypeptide 1Blood-2.390.000
114NUMA1nuclear mitotic apparatus protein 1Blood-2.390.002
115RSAD2radical S-adenosyl methionine domain containing 2Blood+2.380.001
116SMEK1SMEK homolog 1, suppressor of mek1 (Dictyostelium)Blood-2.380.001
117RSRC1arginine/serine-rich coiled-coil 1Blood-2.370.000
118KMT2Alysine (K)-specific methyltransferase 2ABlood-2.360.003
119UBN1ubinuclein 1Blood-2.360.000
120MRPL35mitochondrial ribosomal protein L35Blood-2.360.001
121FYBFYN binding proteinBlood-2.350.003
122HERC4HECT and RLD domain containing E3 ubiquitin protein ligase 4Blood-2.350.000
123DARSaspartyl-tRNA synthetaseBlood-2.340.000
124PURApurine-rich element binding protein ABlood-2.340.003
125ATXN2Lataxin 2-likeBlood-2.340.002
126EIF2S3eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDaBlood-2.340.003
127NAA15N(alpha)-acetyltransferase 15, NatA auxiliary subunitBlood-2.330.002
128IL8interleukin 8Blood-2.330.015
129NFICnuclear factor I/C (CCAAT-binding transcription factor)Blood-2.320.001
130TXN2thioredoxin 2Blood-2.310.001
131SRSF11serine/arginine-rich splicing factor 11Blood-2.310.001
132SCAMP1secretory carrier membrane protein 1Blood-2.310.000
133PMAIP1phorbol-12-myristate-13-acetate-induced protein 1Blood-2.290.002
134YY1YY1 transcription factorBlood-2.290.001
135ILF3interleukin enhancer binding factor 3, 90kDaBlood-2.290.001
136CEP290centrosomal protein 290kDaBlood-2.290.000
137FXR1fragile X mental retardation, autosomal homolog 1Blood-2.270.000
138GAS7growth arrest-specific 7Blood-2.270.001
139KDSR3-ketodihydrosphingosine reductaseBlood-2.260.000
140CLCN3chloride channel, voltage-sensitive 3Blood-2.260.000
141HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunitBlood-2.250.002
142PDP1pyruvate dehyrogenase phosphatase catalytic subunit 1Blood-2.250.005
143PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gammaBlood-2.240.001
144CSPP1centrosome and spindle pole associated protein 1Blood-2.240.000
145SYNJ2synaptojanin 2Blood-2.240.002
146PCBP2poly(rC) binding protein 2Blood-2.230.005
147SLC26A2solute carrier family 26 (anion exchanger), member 2Blood-2.230.003
148SSBSjogren syndrome antigen B (autoantigen La)Blood-2.210.001
150NCOA3nuclear receptor coactivator 3Blood-2.210.015
151SGSM2small G protein signaling modulator 2Blood-2.210.002
152CYTH1cytohesin 1Blood-2.210.001
153ABHD2abhydrolase domain containing 2Blood-2.200.001
154PRDX2peroxiredoxin 2Blood-2.200.000
155LOC100127972uncharacterized LOC100127972Blood-2.190.009
156CDC14Acell division cycle 14ABlood-2.190.002
157RFWD3ring finger and WD repeat domain 3Blood-2.190.000
158RASSF4Ras association (RalGDS/AF-6) domain family member 4Blood-2.180.001
159EHBP1L1EH domain binding protein 1-like 1Blood-2.180.001
160HOOK1hook microtubule-tethering protein 1Blood-2.180.000
161ACACBacetyl-CoA carboxylase betaBlood-2.180.000
162LRRFIP1leucine rich repeat (in FLII) interacting protein 1Blood-2.180.002
163SNX29P2sorting nexin 29 pseudogene 2Blood-2.180.003
164NEK1NIMA-related kinase 1Blood-2.170.000
165ATF7IPactivating transcription factor 7 interacting proteinBlood-2.170.005
166BAZ1Abromodomain adjacent to zinc finger domain, 1ABlood-2.170.011
167HEXIM1hexamethylene bis-acetamide inducible 1Blood-2.160.001
168POGLUT1protein O-glucosyltransferase 1Blood-2.160.001
169USP34ubiquitin specific peptidase 34Blood-2.160.000
170SMC3structural maintenance of chromosomes 3Blood-2.160.002
171SEC63SEC63 homolog (S. cerevisiae)Blood-2.150.005
172SUN1Sad1 and UNC84 domain containing 1Blood-2.140.002
173STK4serine/threonine kinase 4Blood-2.130.022
174C10orf10chromosome 10 open reading frame 10Brain+2.130.000
175SFSWAPsplicing factor, suppressor of white-apricot homolog (Drosophila)Blood-2.130.002
176HMGB1high mobility group box 1Blood-2.120.000
177EEA1early endosome antigen 1Blood-2.120.000
178FCGBPFc fragment of IgG binding proteinBlood-2.120.002
179BRD2bromodomain containing 2Blood-2.110.000
180TCF12transcription factor 12Blood-2.110.006
181DUSP6dual specificity phosphatase 6Blood-2.100.034
182IFI44interferon-induced protein 44Blood+2.100.005
183CCZ1BCCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)Blood-2.100.004
184LPPLIM domain containing preferred translocation partner in lipomaBlood-2.100.001
185PRKCBprotein kinase C, betaBrain-2.090.000
186PKP4plakophilin 4Blood-2.090.001
187ARPC4actin related protein 2/3 complex, subunit 4, 20kDaBlood-2.090.045
188CXorf21chromosome X open reading frame 21Blood-2.090.000
189MAP9microtubule-associated protein 9Blood-2.090.000
191H2AFYH2A histone family, member YBlood-2.080.012
192TACC1transforming, acidic coiled-coil containing protein 1Blood-2.080.002
193B3GAT3beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)Blood-2.080.001
194TOX4TOX high mobility group box family member 4Blood-2.070.012
195RNF25ring finger protein 25Blood-2.070.001
196PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit betaBlood-2.070.004
197UBTFupstream binding transcription factor, RNA polymerase IBlood-2.070.002
198TNFSF14tumor necrosis factor (ligand) superfamily, member 14Blood-2.070.017
199GOLGA8Agolgin A8 family, member ABlood-2.070.001
200EVI5ecotropic viral integration site 5Blood-2.060.001
201CNR1cannabinoid receptor 1 (brain)Brain-2.060.000
202ZFRzinc finger RNA binding proteinBlood-2.060.001
203HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)Blood-2.050.018
204ACBD3acyl-CoA binding domain containing 3Blood-2.050.007
205CALB1calbindin 1, 28kDaBrain-2.040.000
206KTN1kinectin 1 (kinesin receptor)Blood-2.040.003
207TRIM33tripartite motif containing 33Blood-2.040.006
208MRPS31mitochondrial ribosomal protein S31Blood-2.040.001
209SS18synovial sarcoma translocation, chromosome 18Blood-2.030.003
210NMT2N-myristoyltransferase 2Blood-2.030.004
211DGKAdiacylglycerol kinase, alpha 80kDaBlood-2.020.023
212UFL1UFM1-specific ligase 1Blood-2.020.012
214SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 1Blood+1.800.011
215IFIT1interferon-induced protein with tetratricopeptide repeats 1Blood+1.790.014
216EFSembryonal Fyn-associated substrateBlood+1.780.006
217GBP1guanylate binding protein 1, interferon-inducibleBrain+1.750.000
219SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 2Brain-1.660.000
220LPLlipoprotein lipaseBrain-1.650.000
221CA12carbonic anhydrase XIIBrain-1.600.000
222OASL2'-5'-oligoadenylate synthetase-likeBlood+1.600.035
223PPP3CAprotein phosphatase 3, catalytic subunit, alpha isozymeBrain-1.570.000
224GNALguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory typeBrain-1.570.000
225HTR2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupledBrain-1.550.000
226GABRA5gamma-aminobutyric acid (GABA) A receptor, alpha 5Brain-1.530.000
227IFI44Linterferon-induced protein 44-likeBrain+1.520.000
228LAMP5lysosomal-associated membrane protein family, member 5Brain-1.500.000
229ANGPT2angiopoietin 2Brain+1.480.000
230KCNAB1potassium voltage-gated channel, shaker-related subfamily, beta member 1Brain-1.460.000
231PCP4Purkinje cell protein 4Brain-1.450.000
232DACH1dachshund family transcription factor 1Brain-1.410.000
233ADORA2Aadenosine A2a receptorBrain-1.400.000
234SYTL5synaptotagmin-like 5Brain-1.400.000
235ELL2elongation factor, RNA polymerase II, 2Brain+1.380.000
236RPS11ribosomal protein S11Blood+1.380.018
237GJB6gap junction protein, beta 6, 30kDaBrain-1.360.000
238RASD2RASD family, member 2Brain-1.360.000
239BCL11BB-cell CLL/lymphoma 11B (zinc finger protein)Brain-1.350.000
240RGS9regulator of G-protein signaling 9Brain-1.350.000
241SERPINA3serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3Brain+1.350.000
242MOXD1monooxygenase, DBH-like 1Brain-1.350.000
243IFITM1interferon induced transmembrane protein 1Brain+1.340.000
244ISG15ISG15 ubiquitin-like modifierBrain+1.340.000
245WIF1WNT inhibitory factor 1Brain-1.330.000
246RGS14regulator of G-protein signaling 14Brain-1.310.000
247NETO2neuropilin (NRP) and tolloid (TLL)-like 2Brain-1.310.000
248PECAM1platelet/endothelial cell adhesion molecule 1Brain+1.260.000
249RGS8regulator of G-protein signaling 8Brain-1.250.000
250KLHL13kelch-like family member 13Brain-1.240.000
251ARPP21cAMP-regulated phosphoprotein, 21kDaBrain-1.240.000
252SLC35D3solute carrier family 35, member D3Brain-1.230.000
253NAMPTnicotinamide phosphoribosyltransferaseBrain+1.230.000
254SCN4Bsodium channel, voltage-gated, type IV, beta subunitBrain-1.230.000
255XAF1XIAP associated factor 1Brain+1.230.000
256C1QTNF4C1q and tumor necrosis factor related protein 4Brain-1.220.000
257MAFFv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog FBrain+1.210.000
258IFI16interferon, gamma-inducible protein 16Brain+1.210.000
259FAM171Bfamily with sequence similarity 171, member BBrain-1.180.000
260DGKBdiacylglycerol kinase, beta 90kDaBrain-1.170.000
261PCP4L1Purkinje cell protein 4 like 1Brain-1.160.000
262DRD1dopamine receptor D1Brain-1.150.000
263MN1meningioma (disrupted in balanced translocation) 1Brain-1.140.000
264MPPED2metallophosphoesterase domain containing 2Brain-1.130.000
265PSPHphosphoserine phosphataseBrain+1.120.000
266LRRN1leucine rich repeat neuronal 1Brain-1.120.000
267TUSC3tumor suppressor candidate 3Brain-1.100.000
268SNAP25synaptosomal-associated protein, 25kDaBrain-1.080.000
269CACNA2D3calcium channel, voltage-dependent, alpha 2/delta subunit 3Brain-1.080.000
270PYGMphosphorylase, glycogen, muscleBrain-1.080.000
271ARPP19cAMP-regulated phosphoprotein, 19kDaBrain-1.070.000
273ITGB1BP1integrin beta 1 binding protein 1Brain-1.070.000
274PTPN5protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)Brain-1.050.000
275NPTX2neuronal pentraxin IIBrain-1.030.000
276LRRC7leucine rich repeat containing 7Brain-1.030.000
277DLX6distal-less homeobox 6Brain-1.010.000
278EGR4early growth response 4Brain-1.010.000

Expression patterns in normal tissues for genes affiliated with Hiv-1

Search GEO for disease gene expression data for Hiv-1.

Pathways for genes affiliated with Hiv-1

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Pathways related to Hiv-1 according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
Show member pathways
10.8TLR3, CXCL12, CCR2, CCL2, CCR5, CCL11
Show member pathways
10.7CXCL12, CCR2, CCL2, CCR5, CCL11, IL10
Show member pathways
10.7CXCL12, CCR2, CCL2, CCR5, CCL11, IL10
Show member pathways
10.7CXCL12, CCR2, CCL2, CCR5, CCL11, IL10
Show member pathways
10.7CCL11, CCR5, CCL2, CCR2, CXCL12
Show member pathways
10.7CXCL12, CCR2, CCL2, CCR5, CCL11
Show member pathways
10.7CCL11, CCR5, CCL2, CCR2, CXCL12
Show member pathways
10.7CXCL12, CCR2, CCL2, CCR5, CCL11
910.6IL10, CCR2, CXCL12
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
10.6TNIP1, CCL2, IL10
1110.6CCL11, CCL2

Compounds for genes affiliated with Hiv-1

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Compounds related to Hiv-1 according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1rantes4411.2CD209, CCL11, CCR5, CCL2, CXCL12, TLR3
2dexamethasone44 50 29 1214.2TLR3, CXCL12, CCL2, CD209, CCR5, CCL11
3groalpha4411.1IL10, CCL11, CCR5, CCL2, CXCL12
4tarc4411.1CCL2, CXCL12, CCR5, CCL11, IL10
5ccl344 2912.1IL10, CCL11, CCR5, CCL2, CXCL12
6ly2940024411.1CCL2, IL10, TLR3, CXCL12, CCL11
7pge24411.1CCL11, CXCL12, IL10, CCL2, CCR5
8mdms4411.1IL10, CCR5, CCL2, CXCL12
9ccl444 2912.1CXCL12, CCL2, CCR5, CCL11
10zidovudine44 50 1213.1IL10, CCR5, CCL2, CXCL12
11endotoxin4411.1TLR3, CCL2, IL10, CCL11
12sdf 14411.0CCL2, CCR5, CXCL12
13mip 1alpha4411.0CCL2, CCR5, IL10
14shikonin4411.0CCR5, CCL2, CXCL12
15larc4411.0CCL2, CXCL12, CCR5
16lipoteichoic acid4411.0IL10, CCL2, TLR3
17pertussis4411.0CCL11, CXCL12, CCL2
18il 104411.0IL10, CCR5, CCL2
19tak-7792911.0CCR2, CCR5
20sb 20358044 6012.0IL10, CCL11, CCL2, CXCL12
21ccl22911.0CCR2, CCR5
22peptidoglycan44 2912.0IL10, CCL11, TLR3
23polysaccharide4411.0CD209, CXCL12, CCR5, CCL2
24ccl112911.0CCR5, CCR2
25ccl162911.0CCR5, CCR2
26quinine44 29 3 50 1215.0CXCL12, CCR5, IL10
27histamine44 29 2513.0CCL11, IL10, CCL2, CCR5
28ccl82911.0CCR5, CCR2
29ifn-alpha4410.9CXCL12, TLR3, IL10
30bicyclam4410.9CXCL12, CCR5
3115-deoxy-delta-12,14-prostaglandin j24410.9IL10, CCL11, CCL2
32allergens4410.9CD209, IL10, CCL11
33rapamycin4410.9CCR5, KAT5, CXCL12, IL10
34ccl72910.9CCR2, CCR5
35vmip-ii2910.9CCR2, CCR5
36ccl132910.9CCR5, CCR2
37sb 22500260 2911.8CCR5, CCR2
38tc 140126010.8CCR2, CCR5
39actinomycin d4410.8CXCL12, CCL2, CCR5, CCL11
40sb 2656106010.8CCR2, CCR5
41rs 5043936010.8CCR2, CCR5
42galactosylceramide4410.8CCR5, CXCL12
43grobeta4410.8CXCL12, CCL2
44maraviroc44 60 50 29 1214.7CCR2, CCR5
45toxin-14410.7IL10, CCL2
46mcp 14410.6CCL2, IL10
47cytochalasin d44 6011.6CXCL12, CCL2, CCR5
48triamcinolone acetonide44 2911.6IL10, CCR5
49simvastatin44 50 60 29 25 1215.5CCR5, CCL2, IL10
50herbimycin a44 6011.3CXCL12, CCL2, CCL11

GO Terms for genes affiliated with Hiv-1

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Cellular components related to Hiv-1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.9CD209, TNIP1, VPRBP, CCR2, CCL2, CCR5

Biological processes related to Hiv-1 according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.1IL10, CCL11, CCR5, CCL2, CCR2, TNIP1
2chemotaxisGO:00693511.0CCL11, CCR5, CCL2, CCR2, CXCL12
3viral processGO:01603211.0KAT5, VPRBP, CCR2, CCR5, HTATIP2, RPL3
4chemokine-mediated signaling pathwayGO:07009811.0CXCL12, CCR2, CCL2, CCR5
5cellular calcium ion homeostasisGO:00687411.0CXCL12, CCR2, CCL2, CCL11
6positive regulation of monocyte chemotaxisGO:09002610.9CXCL12, CCR2, CCR5
7viral genome replicationGO:01907910.9CD209, HTATSF1, CCL2
8positive regulation of inflammatory responseGO:05072910.9TLR3, TNIP1, CCR2
9positive regulation of endothelial cell proliferationGO:00193810.9CCL11, CCL2, CXCL12
10positive regulation of immune complex clearance by monocytes and macrophagesGO:09026510.9CCL2, CCR2
11cellular response to lipopolysaccharideGO:07122210.8CCL2, CCR5, IL10
12regulation of transcription from RNA polymerase II promoterGO:00635710.8TARBP1, TARBP2, HTATSF1, HTATIP2
13regulation of vascular endothelial growth factor productionGO:01057410.8CCL2, CCR2
14immune responseGO:00695510.8CXCL12, CCR2, CCR5, CCL11
15cellular homeostasisGO:01972510.8CCL2, CCR2
16dendritic cell chemotaxisGO:00240710.7CCR5, CCR2
17positive regulation of T cell activationGO:05087010.7CCL2, CCR2
18cellular response to interferon-gammaGO:07134610.6CCL2, TLR3
19response to activityGO:01482310.6IL10, CCL2
20response to radiationGO:00931410.6CXCL12, CCL11
21leukocyte cell-cell adhesionGO:00715910.5CD209, TNIP1
22JAK-STAT cascadeGO:00725910.3CCL2, CCR2

Molecular functions related to Hiv-1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR2 chemokine receptor bindingGO:03172710.6CCL2, CCR2
2chemokine receptor activityGO:00495010.6CCR5, CCR2
3chemokine activityGO:00800910.5CCL11, CCL2, CXCL12
4C-C chemokine receptor activityGO:01649310.3CCR5, CCR2

Products for genes affiliated with Hiv-1

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hiv-1

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27ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet