MCID: HV1006
MIFTS: 83

Hiv-1 malady

Genetic diseases (common), Immune diseases categories

Summaries for Hiv-1

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MedlinePlus:32 Hiv stands for human immunodeficiency virus. it kills or damages the body's immune system cells. aids stands for acquired immunodeficiency syndrome. it is the most advanced stage of infection with hiv. hiv most often spreads through unprotected sex with an infected person. it may also spread by sharing drug needles or through contact with the blood of an infected person. women can give it to their babies during pregnancy or childbirth. the first signs of hiv infection may be swollen glands and flu-like symptoms. these may come and go a month or two after infection. severe symptoms may not appear until months or years later. a blood test can tell if you have hiv infection. your health care provider can perform the test, or call the national referral hotline at 1-800-cdc-info (24 hours a day, 1-800-232-4636 in english and en español; 1-888-232-6348 - tty). there is no cure, but there are many medicines to fight both hiv infection and the infections and cancers that come with it. people can live with the disease for many years.

MalaCards based summary: Hiv-1, also known as hiv/aids, is related to aids dementia complex and encephalitis. An important gene associated with Hiv-1 is CX3CR1 (chemokine (C-X3-C motif) receptor 1), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The drugs zalcitabine and didanosine and the compounds rantes and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, t cells and skin, and related mouse phenotypes are immune system and hematopoietic system.

OMIM:45 The pathogenesis of HIV infection and the progression from infection to AIDS vary significantly between exposed... (609423) more...

Aliases & Classifications for Hiv-1

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Hiv-1, Aliases & Descriptions:

Name: Hiv-1 45 30
Hiv/aids 45 30 32 3
Aids 45 43 3
Aids, Delayed/rapid Progression to 45 10
Hiv1 Infection 45 30
Rapid Progression to Aids from Hiv1 Infection 45
Human Immunodeficiency Virus I Infection 60
Human Immunodeficiency Virus Type 1 45
 
Acquired Immunodeficiency Syndrome 60
Aids, Rapid Progression to 45
Aids, Slow Progression to 45
Hiv-1 Viremia 45
Hiv-Infection 60
Hiv Type 1 45
Hiv1 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Immune diseases


External Ids:

OMIM45 609423

Related Diseases for Hiv-1

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Diseases related to Hiv-1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1038)
idRelated DiseaseScoreTop Affiliating Genes
1aids dementia complex31.7CCR5, CXCL12
2encephalitis31.5CCL3, TLR3, CCL2, CCR5
3syphilis31.2CCR5
4acquired immunodeficiency syndrome31.2KIR3DL1, CCL3L1, CCR5, CCR2, CXCL12
5connective tissue disease31.1HLA-C, IL10, CCL2
6monocytic leukemia31.1IFNG, CCL2, CXCL12
7leishmaniasis31.1IFNG, IL10
8malaria31.1IFNG, IL10
9periodontitis31.0CD209, CCR5, CCL2, IL10
10hepatitis c31.0TLR3, IL10, IFNG, CCR5
11visceral leishmaniasis31.0IL10, IFNG
12tuberculoid leprosy30.8IL10, IFNG
13aspergillosis30.8IFNG, CCL3
14tuberculosis30.7CCL3, CD209, IL10, IL4R, IFNG, CXCL12
15intraocular lymphoma30.7IL10
16pulmonary tuberculosis30.7IFNG, IL10, CXCR1, CXCL12, CCL3
17pleural tuberculosis30.7CCL2, IFNG, CCL3
18periapical granuloma30.6CCL2, CCR5, CCL3
19hepatitis b30.6HLA-C, TLR3, IFNG, KIR3DL1
20alcoholic hepatitis30.6CCL2, CCL3
21schistosomiasis30.6CCR5, IFNG, IL10
22tropical spastic paraparesis30.6IFNG, CCL3
23cutaneous leishmaniasis30.5IL10, IFNG
24uveitis30.5IL10, IFNG, CCL11, CCR5, CCL2, CXCR1
25dermatitis30.5IFNG, CCL11, CX3CR1
26systemic lupus erythematosus30.5CCL3, CCL2, CCR5, IL10, CX3CR1, IL4R
27lepromatous leprosy30.5IL10, IFNG
28arthritis30.4IL10, HLA-C, IFNG, CXCR1, CCL3, CCR5
29myasthenia gravis30.4IL10, IFNG, CCR5
30atherosclerosis30.3CXCR1, CD209, IL10, CCL11, CCR5, CCL2
31folliculitis30.2CCL11
32influenza30.2IFNG, TLR3, CCL11, CCR5
33interstitial lung disease30.2CCL11, CCL2, CCL3
34relapsing-remitting multiple sclerosis30.1IFNG, IL10
35pneumonia30.1CCL2, CCL3, TLR3, IL10, CCL11
36acute graft versus host disease30.1IFNG, IL10, KIR3DL1
37corneal ulcer30.1CCL11
38leukemia29.9CXCL12, CXCR1, HLA-C, CCL3, CCL11, IFNG
39bronchiolitis29.9CCL3, CCL11, IL4R
40skin disease29.9CCL11, CXCR1, IL10, IFNG, HLA-C
41burkitt lymphoma29.8IL4R, CCL3, CXCR1
42breast cancer29.7CXCR1, CXCL12, CCL11, KIR3DL1, IL4R, CCL3
43ulcerative colitis29.7CXCR1, CCL11, TLR3, IFNG, IL10
44colorectal cancer29.5IL4R, IFNG, CXCR1, CXCL12
45psoriasis29.5CCL11, CCL2, IFNG, IL10, KIR3DL1, IL4R
46osteoarthritis29.4CX3CR1, TLR3, CXCL12, IL4R, CXCR1, CCL3
47atopic dermatitis29.4CX3CR1, CXCR1, CCL11, CCL2, IL4R, IL10
48atopy29.4IL4R, IL10, CCL11, IFNG
49asthma29.3CCR5, CCL2, CCL3, CXCR1, CX3CR1, CXCL12
50viral infectious disease29.1CCL3, CCL2, CCR5, CCL11, IFNG, IL10

Graphical network of the top 20 diseases related to Hiv-1:



Diseases related to hiv-1

Symptoms for Hiv-1

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Clinical features from OMIM:

609423

Drugs & Therapeutics for Hiv-1

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Genetic Tests for Hiv-1

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Anatomical Context for Hiv-1

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MalaCards organs/tissues related to Hiv-1:

31
Skeletal muscle, T cells, Skin, Monocytes, Liver, Brain, Endothelial, Testes, B cells, Myeloid, Nk cells, Breast, Bone, Eye, Whole blood, Neutrophil, Cortex, Adipocyte, Lung, Placenta, Colon, Kidney, Lymph node, Thymus, Thyroid, Prostate, Hypothalamus, Pituitary, Bone marrow, Spleen, Cerebellum, Spinal cord, Smooth muscle, Small intestine, Testis, Tonsil

Animal Models for Hiv-1 or affiliated genes

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MGI Mouse Phenotypes related to Hiv-1:

35 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.8CD209, TLR3, TNIP1, CXCL12, CX3CR1, CCL3
2MP:000539711.7CCL3, CX3CR1, CXCL12, TNIP1, TLR3, CCR2
3MP:001076811.6CCL3, CX3CR1, CXCL12, TNIP1, TLR3, CCR2
4MP:000537611.5TLR3, TNIP1, CX3CR1, CCL3, CCR2, CCL2
5MP:000538411.4TNIP1, CXCL12, CX3CR1, CCL3, CCR2, CCL2
6MP:000538111.4TNIP1, CX3CR1, CCL3, CCR2, CCL2, CCR5
7MP:000363111.4CCL3, CX3CR1, CXCL12, TLR3, CCR2, CCL2
8MP:000538511.4TLR3, TNIP1, CXCL12, CX3CR1, CCR2, CCL2
9MP:000537011.4TNIP1, CXCL12, CCR2, CCL2, CCR5, IFNG
10MP:000301211.4TNIP1, CXCL12, CX3CR1, CCR2, CCR5, IFNG
11MP:000536911.2TLR3, CXCL12, CX3CR1, CCL2, CCR5, IFNG
12MP:000287311.1CXCL12, CX3CR1, CXCR1, CCL2, CCL11, IFNG
13MP:000538611.1TLR3, CX3CR1, CCL3, CCR2, CCL2, CCR5
14MP:000538911.1TLR3, CXCL12, CX3CR1, CCL2, CCR5, IFNG
15MP:000200611.1TLR3, CCR2, CCL2, CCR5, IFNG, IL10
16MP:001077110.9CX3CR1, CCL2, IFNG, IL4R, IL10, TNIP1
17MP:000538810.9TLR3, CCR2, CCL11, IFNG, IL4R, IL10
18MP:000539110.8CX3CR1, CCR2, CCL2, CCR5, IFNG, IL10
19MP:000537810.8TNIP1, CX3CR1, CCL3, CCR2, CCL2, IFNG

Publications for Hiv-1

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Articles related to Hiv-1:

(show top 50)    (show all 5035)
idTitleAuthorsYear
1
Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers. (25408842)
2014
2
HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuse. (25355898)
2014
3
Emergence of a distinct HIV-specific IL-10-producing CD8+ T-cell subset with immunomodulatory functions during chronic HIV-1 infection. (23897063)
2013
4
The HIV-1 Nef protein interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA. (22672539)
2012
5
In vitro infection of human umbilical cord blood CD34+ hematopoietic progenitor cells by HIV-1 CRF07_BC enveloped pseudovirus. (22934658)
2012
6
HIV-1 gp120 and drugs of abuse: interactions in the central nervous system. (22591361)
2012
7
Characterization of the interaction of full-length HIV-1 Vif protein with its key regulator CBFI^ and CRL5 E3 ubiquitin ligase components. (22479405)
2012
8
Elicitation of both anti HIV-1 Env humoral and cellular immunities by replicating vaccinia prime Sendai virus boost regimen and boosting by CD40Lm. (23236521)
2012
9
The genetic associations and epistatic effects of the CCR5 promoter and CCR2-V64I polymorphisms on susceptibility to HIV-1 infection in a Northern Han Chinese population. (23057571)
2012
10
CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates. (21165790)
2011
11
HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND). (21315782)
2011
12
Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3. (21360055)
2011
13
HIV-1 Nef triggers macrophage fusion in a p61Hck- and protease-dependent manner. (20488787)
2010
14
A rapid recombination assay of HIV-1 using murine CD52 as a novel biomarker. (18407776)
2008
15
HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down- regulation: analysis using short interfering RNA and knock-out mice. (18296443)
2008
16
Structure-function relationship of novel X4 HIV-1 entry inhibitors - L- and D-arginine peptide-aminoglycoside conjugates. (18028446)
2007
17
Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness. (16959283)
2007
18
Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef. (16916529)
2006
19
Molecular switch for alternative conformations of the HIV-1 V3 region: implications for phenotype conversion. (16966601)
2006
20
Transcellular protein transduction using the Tat protein of HIV-1. (15722166)
2005
21
HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses. (16001085)
2005
22
Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells. (15590971)
2004
23
MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment. (14767809)
2004
24
Activity of alpha- and theta-defensins against primary isolates of HIV-1. (15210812)
2004
25
Blockade of HIV-1 infection of New World monkey cells occurs primarily at the stage of virus entry. (12186836)
2002
26
Rescue of HIV-1 receptor function through cooperation between different forms of the CCR5 chemokine receptor. (12154092)
2002
27
Characterization of the nuclear import pathway for HIV-1 integrase. (11278458)
2001
28
Osteoblasts in HIV-infected patients: HIV-1 infection and cell function. (11698696)
2001
29
Inhibition of HIV-1 infection by down-regulation of the CXCR4 co-receptor using an intracellular single chain variable fragment against CXCR4. (11313818)
2001
30
Induction of immune responses and break of tolerance by DNA against the HIV-1 coreceptor CCR5 but no protection from SIVsm challenge. (11118363)
2000
31
Stimulating effect of HIV-1 coat protein gp120 on corticotropin-releasing hormone and arginine vasopressin in the rat hypothalamus: involvement of nitric oxide. (11085902)
2000
32
Enhancement of the basal-level activity of HIV-1 long terminal repeat by HIV-1 nucleocapsid protein. (10704334)
2000
33
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. (10620603)
2000
34
FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. (9973611)
1999
35
HIV-1 Tat protein mimicry of chemokines. (9789057)
1998
36
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. (9301668)
1997
37
In vitro chromatin assembly of the HIV-1 promoter. ATP-dependent polar repositioning of nucleosomes by Sp1 and NFkappaB. (9211915)
1997
38
Identification of the envelope V3 loop as a determinant of a CD4-negative neuronal cell tropism for HIV-1. (8610455)
1996
39
Random important alterations in HIV-1 viral quasispecies after antiviral treatment. (11324825)
1996
40
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. (8906795)
1996
41
Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion. (8659115)
1996
42
A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression. (9150887)
1996
43
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. (7716549)
1995
44
HIV-1 gp41 selectively inhibits spontaneous cell proliferation of human cell lines and mitogen- and recall antigen-induced lymphocyte proliferation. (8847089)
1995
45
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. (7588629)
1995
46
Nef protein of HIV-1 has B-cell stimulatory activity. (8086129)
1994
47
Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells. (8011246)
1994
48
Downregulation of CD28 surface antigen on CD4+ and CD8+ T lymphocytes during HIV-1 infection. (7906302)
1994
49
Antibody-dependent cellular cytotoxicity (ADCC) is directed against immunodominant epitopes of the envelope proteins of human immunodeficiency virus 1 (HIV-1). (1282012)
1992
50
Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum. (2190096)
1990

Variations for Hiv-1

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Clinvar genetic disease variations for Hiv-1:

6 (show all 11)
id Gene Variation Type Significance SNP ID Assembly Location
1CCL2CCL2, -2136A-Tsingle nucleotide variantPathogenic
2CCL2CCL2, 767C-Gsingle nucleotide variantPathogenic
3IL10IL10, -592C-Asingle nucleotide variantPathogenic, risk factor
4TLR3NM_003265.2(TLR3): c.1234C> T (p.Leu412Phe)single nucleotide variantPathogenicrs3775291GRCh37Chr 4, 187004074: 187004074
5NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs)deletionPathogenic, risk factorrs333GRCh37Chr 3, 46414947: 46414978
6NM_000579.3(CCR5): c.303T> A (p.Cys101Ter)single nucleotide variantPathogenicrs1800560GRCh37Chr 3, 46414696: 46414696
7NM_000579.3(CCR5): c.180G> T (p.Arg60Ser)single nucleotide variantPathogenicrs1800940GRCh37Chr 3, 46414573: 46414573
8CCR5CCR5, 2459A-Gsingle nucleotide variantPathogenic
9CCR2NM_001123041.2(CCR2): c.190G> A (p.Val64Ile)single nucleotide variantPathogenicrs1799864GRCh37Chr 3, 46399208: 46399208
10CCL11CCL11, -1385G-Asingle nucleotide variantPathogenic
11CXCL12NM_000609.6(CXCL12): c.266+535G> Asingle nucleotide variantPathogenicrs387906400GRCh37Chr 10, 44873550: 44873550

Expression for genes affiliated with Hiv-1

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LifeMap Discovery
Genes differentially expressed in tissues of Hiv-1 patients vs. healthy controls: 30 (show all 8)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1FCN1ficolin (collagen/fibrinogen domain containing) 1Skin+3.890.000
2IRF1interferon regulatory factor 1Skin+3.580.000
3STAT1signal transducer and activator of transcription 1, 91kDaSkin+3.530.000
4RARRES3retinoic acid receptor responder (tazarotene induced) 3Skin+3.490.000
5SERPINB1serpin peptidase inhibitor, clade B (ovalbumin), member 1Skin+3.410.000
6CCL19chemokine (C-C motif) ligand 19Skin+3.320.003
7IFI27interferon, alpha-inducible protein 27Blood+3.250.000
8XAF1XIAP associated factor 1Skin+3.040.000

Search GEO for disease gene expression data for Hiv-1.

Pathways for genes affiliated with Hiv-1

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Pathways related to Hiv-1 according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
11.4IL10, CXCL12, CX3CR1, IL4R, IFNG, CCL11
2
Show member pathways
11.3TLR3, CXCL12, CX3CR1, CCL3, CCR2, CCL2
3
Show member pathways
11.2CXCL12, CX3CR1, CCL3, CCR2, CCL2, CCR5
4
Show member pathways
11.2CXCL12, CX3CR1, CCL3, CCR2, CCL2, CCR5
5
Show member pathways
11.1CXCL12, CX3CR1, CXCR1, CCL3, CCR2, CCL2
6
Show member pathways
11.1CXCL12, CX3CR1, CXCR1, CCL3, CCR2, CCL2
7
Show member pathways
11.1CXCL12, CX3CR1, CXCR1, CCL3, CCR2, CCL2
8
Show member pathways
11.1CCL11, CCL3L1, CCR5, CCL2, CCR2, CCL3
9
Show member pathways
11.1CXCL12, CCL3, CCL2, CCL3L1, CCL11, IFNG
10
Show member pathways
11.0HLA-C, CXCL12, CCL11, IFNG, IL4R, IL10
11
Show member pathways
11.0CXCL12, CCL3, CCR2, CCL2, CCR5, CCL3L1
12
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
10.9TLR3, CCL3, CCL2, CCL3L1, IFNG, IL10
13
Show member pathways
10.8HLA-C, TLR3, CCL2, IFNG, CD209
1410.8CXCL12, CCL3, CCL2, CCL3L1, IFNG
15
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
10.8TNIP1, CCL2, IFNG, IL10
16
Show member pathways
10.8CCR5, IFNG, IL4R, IL10
1710.7IL10, IFNG, CCL2
1810.7CCL2, CCR2, CX3CR1
19
Show member pathways
IL27-mediated signaling events36
10.7TLR3, IFNG, IL10
2010.7IL10, CCR2, CXCL12
21
Show member pathways
Type III interferon signaling36
10.7IL10, IL4R, IFNG
22
Show member pathways
10.7IL10, IFNG, CCL3
2310.7IFNG, CCL2, CCR2
2410.7CCR2, CCL2, IFNG
2510.7CCL11, IL4R, IL10
26
Show member pathways
10.7IFNG, CCL3L1, CCL3
27
Show member pathways
10.7IL4R, IFNG, TLR3
28
Show member pathways
Immune response IL 12 induced IFN gamma production58
10.7IFNG, CCR5, CCL3
2910.6IL10, IFNG
3010.6CCL2, CCL11
3110.6CCL2, CCL3

Compounds for genes affiliated with Hiv-1

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Compounds related to Hiv-1 according to GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1rantes4311.9CCL2, CCR5, CCL3L1, CCL11, IFNG, IL4R
2dexamethasone43 49 28 1214.7TLR3, CXCL12, CXCR1, CCL3, CCL2, CCR5
3calcium43 49 24 1214.7CXCL12, CX3CR1, CXCR1, CCL3, CCR2, CCL2
4ccl343 2812.7CX3CR1, CXCL12, CXCR1, CCL3, CCL2, CCR5
5tarc4311.6IL10, IL4R, IFNG, CCL11, CCR5, CCL2
6actinomycin d4311.5CXCL12, CXCR1, CCL3, CCL2, CCR5, CCL11
7vegf4311.5CXCL12, CX3CR1, CXCR1, CCL3, CCL2, CCL11
8groalpha4311.4CXCL12, IL10, CCL11, CCR5, CCL2, CCL3
9ccl443 2812.4CXCL12, CX3CR1, CCL3, CCL2, CCR5, CCL3L1
10endotoxin4311.4TLR3, CXCR1, CCL3, CCL2, CCL11, IFNG
11histamine43 28 2413.4CCL3, CCL2, CCR5, CCL11, IFNG, IL4R
12pge24311.4CXCL12, CCL3, CCL2, CCR5, CCL11, IFNG
13cycloheximide4311.4CXCL12, CXCR1, CCL3, CCL2, IFNG, IL4R
14il 104311.4CCL3, CCL2, CCR5, IFNG, IL4R, IL10
15sb 20358043 5912.3CXCL12, CCL3, CCL2, CCL11, IFNG, IL10
16ly2940024311.3TLR3, CXCL12, CCL3, CCL2, CCL11, IL10
17mdms4311.3CXCL12, CCL3, CCL2, CCR5, IL10
18allergens4311.3CCL11, IFNG, IL4R, IL10, CD209
19zidovudine43 49 1213.2CXCL12, CCL3, CCL2, CCR5, IL10
20phosphatidylinositol4311.2TLR3, CXCL12, CX3CR1, CXCR1, CCL2, CCL11
21simvastatin43 49 59 28 24 1216.2CCL3, CCL2, CCR5, IFNG, IL10
22herbimycin a43 5912.2CXCL12, CXCR1, CCL2, CCL11, IFNG
23mip 1alpha4311.2CCL3, CCL2, CCR5, IL10
24shikonin4311.2CCR5, CCL2, CCL3, CXCL12
25ionomycin4311.2CCL3, CCL11, IFNG, IL4R, IL10
26larc4311.2CCR5, CCL2, CCL3, CXCL12
27cyclosporin a43 28 5913.2CCL3, CCR5, CCL11, IFNG, IL4R, IL10
28fmlp4311.2CCL11, CCL2, CCL3, CXCR1, CXCL12
29gm-csf43 2812.2CCL3, CCL2, IFNG, IL10
30lipoteichoic acid4311.2IL10, CCL2, CCL3, TLR3
31polyinosinic-polycytidylic acid4311.1IL10, IFNG, CCL3, TLR3
32poly(i-c)4311.1TLR3, CCL3, CCL11, IFNG
33peptidoglycan43 2812.1TLR3, CCL3, CCL11, IL10
34sdf 14311.1CXCL12, CCL2, CCR5
35ribavirin43 49 1213.0CCL3, CCR5, IFNG, IL10
36ifn-alpha4311.0TLR3, CXCL12, IFNG, IL10
37tc 140125911.0CXCR1, CCR2, CCR5
38sb 22500259 2812.0CXCR1, CCR2, CCR5
39sb 2656105911.0CXCR1, CCR2, CCR5
40rs 5043935911.0CXCR1, CCR2, CCR5
41thymidine43 2412.0CXCL12, CCL3, CCL11, IFNG, IL4R, IL10
4215-deoxy-delta-12,14-prostaglandin j24311.0CCL2, CCL11, IFNG, IL10
43grobeta4310.9CCL2, CXCR1, CXCL12
44maraviroc43 59 49 28 1214.9CCR5, CCR2, CXCR1
45mcp 14310.8CCL3, CCL2, IL10
46toxin-14310.8CCL3, CCL2, IL10
47leukotriene b443 59 2412.8CCL11, CCL2, CCL3, CXCR1
48polysaccharide4310.7CXCL12, CCL3, CCL2, CCR5, CD209
49imiquimod43 59 28 1213.7IL10, IFNG, TLR3
50il-124310.4IL10, IFNG, CCL2

GO Terms for genes affiliated with Hiv-1

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Cellular components related to Hiv-1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:000557611.0CXCL12, CCL3, CCL2, CCL11, IFNG, CD209
2integral component of plasma membraneGO:000588711.0KIR3DS1, HLA-C, TLR3, CX3CR1, CCR2, CCR5
3extracellular spaceGO:000561510.7CXCL12, CCL3, CCL2, CCL11, IFNG, IL4R

Biological processes related to Hiv-1 according to GeneCards Suite gene sharing:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:000695411.6TLR3, TNIP1, CXCR1, CCL3, CCR2, CCL2
2chemotaxisGO:000693511.5CCL11, CXCL12, CX3CR1, CXCR1, CCL3, CCR2
3immune responseGO:000695511.5HLA-C, CXCL12, CCR2, CCR5, CCL11, IL4R
4signal transductionGO:000716511.4TLR3, CXCL12, CCL2, CCL11, IL4R, KIR3DL1
5chemokine-mediated signaling pathwayGO:007009811.4CXCL12, CX3CR1, CXCR1, CCR2, CCL2, CCR5
6cellular response to lipopolysaccharideGO:007122211.3CX3CR1, CCL2, CCR5, IFNG, IL10
7cellular calcium ion homeostasisGO:000687411.3CXCL12, CCL3, CCR2, CCL2, CCL11
8G-protein coupled receptor signaling pathwayGO:000718611.3CXCL12, CX3CR1, CXCR1, CCL2, CCR5
9positive regulation of inflammatory responseGO:005072911.2CCR2, CCL3, TNIP1, TLR3
10cell surface receptor signaling pathwayGO:000716611.2CXCR1, CCL2, CCR5, IFNG
11innate immune responseGO:004508711.2HLA-C, TLR3, CCR2, KIR3DS1, CD209
12cytokine-mediated signaling pathwayGO:001922111.2IFNG, CCL2, CCR2, HLA-C
13macrophage chemotaxisGO:004824611.1CX3CR1, CCL3, CCL2
14positive regulation of monocyte chemotaxisGO:009002611.1CXCL12, CCR2, CCR5
15dendritic cell chemotaxisGO:000240711.1CXCR1, CCR2, CCR5
16cellular response to interferon-gammaGO:007134611.1CCL2, CCL3, TLR3
17positive regulation of tumor necrosis factor productionGO:003276011.1IFNG, CCL3, TLR3
18neutrophil chemotaxisGO:003059311.1CCL3, CCL2, IFNG
19negative regulation of angiogenesisGO:001652511.1CCL2, CCR2, CX3CR1
20cellular defense responseGO:000696811.1CX3CR1, CCR2, CCR5
21positive regulation of endothelial cell proliferationGO:000193811.1CXCL12, CCL2, CCL11
22MAPK cascadeGO:000016511.1CCR5, CCL2, CCL3
23positive regulation of immune complex clearance by monocytes and macrophagesGO:009026511.0CCR2, CCL2
24signalingGO:002305211.0CCL3, CCR5
25regulation of vascular endothelial growth factor productionGO:001057411.0CCL2, CCR2
26cytoskeleton organizationGO:000701011.0CCL11, CCL2, CCL3
27astrocyte cell migrationGO:004361511.0CCL3, CCL2
28release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:001480811.0CCL3, CCR5
29response to cholesterolGO:007072311.0CCL3, CCR5
30lymphocyte chemotaxisGO:004824711.0CCL3, CCL2
31positive regulation of MHC class II biosynthetic processGO:004534811.0IFNG, IL10
32defense response to bacteriumGO:004274211.0TLR3, IFNG, IL10
33microglial cell activation involved in immune responseGO:000228211.0TLR3, CX3CR1
34positive regulation of chemokine biosynthetic processGO:004508011.0TLR3, IFNG
35regulation of cell shapeGO:000836010.9CCL11, CCL2, CCL3
36eosinophil chemotaxisGO:004824510.9CCL11, CCL3
37response to virusGO:000961510.9IFNG, CCL11, CXCL12
38cellular homeostasisGO:001972510.9CCR2, CCL2
39viral genome replicationGO:001907910.9CD209, CCL2
40positive regulation of T cell activationGO:005087010.8CCR2, CCL2
41negative regulation of growth of symbiont in hostGO:004413010.8IFNG, IL10
42defense response to protozoanGO:004283210.8IL4R, IFNG
43cell adhesionGO:000715510.8CXCL12, CX3CR1, CCL2, CCL11
44positive regulation of interleukin-1 beta secretionGO:005071810.8CCL3, IFNG
45monocyte chemotaxisGO:000254810.7CCL3, CCL2
46negative regulation of osteoclast differentiationGO:004567110.7CCL3, TLR3
47positive regulation of interleukin-12 productionGO:003273510.6IFNG, TLR3
48regulation of sensory perception of painGO:005193010.5IL10, CCL3
49response to radiationGO:000931410.3CCL11, CXCL12

Molecular functions related to Hiv-1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:000495010.8CCR5, CCR2, CXCR1, CX3CR1
2chemokine activityGO:000800910.7CXCL12, CCL3, CCL2, CCL11
3C-C chemokine receptor activityGO:001649310.6CCR5, CCR2
4CCR2 chemokine receptor bindingGO:003172710.3CCL2, CCR2

Products for genes affiliated with Hiv-1

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3CDC
13ExPASy
14FMA
22GTR
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