Hiv-1, Resistance to malady

MalaCards: Hiv-1, Resistance to, also known as hiv1, resistance to, is related to thrombosis and hiv infection, susceptibility/resistance to. An important gene associated with Hiv-1, Resistance to is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Regulation of eIF4 and p70S6K. The compounds rapamycin and bevirimat have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related mouse phenotypes are hematopoietic system and immune system.

OMIM: 609423

hiv-1, resistance to 33 hiv1, resistance to 33

Diseases related to hiv-1, resistance to by text searches and GeneDecks gene sharing:

(show top 50)    (show all 300)

id	Related Disease	Score	Top Affiliating Genes
1	thrombosis	26.8	CD40, IL10, CCL2, HLA-A, CXCL12
2	hiv infection, susceptibility/resistance to	13.4	CCR2, CCR5
3	aids, resistance to	13.4	CCR5, CXCL12
4	erdheim-chester disease	13.3	CCL2, CCR5
5	exanthem	13.3	CD4, CCL11
6	mesangial proliferative glomerulonephritis	13.2	CCL2, CCR5
7	chronic eosinophilic pneumonia	13.2	IL10, CCL11
8	sympathetic ophthalmia	13.2	IL10, CCL2
9	pneumoconiosis	13.2	CCR2, CCL2, CCR5
10	coronary arteriosclerosis	13.1	CCL2, CCR5, CXCL12
11	asthma	13.1	CCL2, CCL11, CCR5
12	intermediate uveitis	13.1	IL10, CCR5
13	retinal hemangioblastoma	13.0	CXCL12, CXCR4
14	opportunistic bacterial infectious disease	13.0	CD4, CCR5
15	myelokathexis	13.0	CXCL12, CXCR4
16	cystoid macular edema	13.0	IL10, CXCL12
17	eosinophilic pneumonia	13.0	IL10, CCL2, CCL11
18	whim syndrome	13.0	CXCL12, CXCR4
19	keratoconjunctivitis	13.0	CD4, CCL2, CCL11
20	chronic obstructive pulmonary disease	13.0	CCL2, CCL11, CCR5
21	cryptosporidiosis	13.0	CD4, CCL11
22	mycobacterium avium complex disease	13.0	CD4, IL10
23	arterial occlusive disease	12.9	CD40, CCL2, CCR5
24	arterial calcification	12.9	CD40, CCR2, CCL2
25	retinal vein occlusion	12.9	IL10, CCL2, CXCL12
26	cutaneous leishmaniasis	12.9	IL10, CCL2, CCR5
27	retinopathy of prematurity	12.9	IL10, CCL11, CXCL12
28	coccidioidomycosis	12.9	CD4, IL10
29	central nervous system lymphoma	12.9	IL10, CCL2, CXCL12
30	relapsing polychondritis	12.8	IL10, CCL2
31	hepatic fibrosis renal cysts mental retardation	12.8	IL10, CCL2, CCR5
32	malt lymphoma	12.8	CD40, CXCL12, CXCR6
33	usual interstitial pneumonia	12.8	CCL2, CXCL12, CXCR4
34	guillain-barre syndrome	12.8	IL10, CCR5, CXCL12
35	allergic asthma	12.8	IL10, CCL2, CCL11
36	juvenile rheumatoid arthritis	12.8	IL10, CCL2, CCR5
37	proliferative diabetic retinopathy	12.7	IL10, CCL2, CXCL12
38	wheat allergic reaction	12.7	CD4, IL10, CCL11
39	gastrointestinal system disease	12.7	CD4, CD40, CCL2
40	primary immunodeficiency disease	12.7	CD4, CD40
41	viral encephalitis	12.7	IL10, CCL2
42	eczema	12.7	IL10, CCL2, CCL11, CCR5
43	peripheral t-cell lymphoma	12.7	CD4, IL10, CCL11
44	cork-handlers' disease	12.7	IL10, CCL2, CCL11, CCR5
45	hepatitis b	12.7	CD40, IL10, CCR5
46	pulmonary plasma cell granuloma	12.6	CD4, IL10, CCL2, CCL11
47	intraocular lymphoma	12.6	IL10, CXCL12, CXCR4
48	coronary artery anomaly	12.6	CCL2, CCL11, CCR5, CXCR4
49	hypergammaglobulinemia	12.5	CD4, CD40, IL10
50	b-cell non-hodgkin lymphoma	12.5	CD40, IL10, CCR5

Clinical features from OMIM: 609423

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hiv-1, resistance to:

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MGI Mouse Phenotypes related to hiv-1, resistance to:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.8	CCR2, CCL11, RNF2
2	immune system phenotype	MP:0005387	9.6	RNF2, CD4
3	liver/biliary system phenotype	MP:0005370	9.5	CCR2, CCR5, RNF2
4	tumorigenesis	MP:0002006	8.5	CCR5, IL10, CCR2, CCL2, RNF2, CXCR6
5	no phenotypic analysis	MP:0003012	7.8	CXCL12, RNF2, CCR5, CCR2, IL10, CD4
6	digestive/alimentary phenotype	MP:0005381	7.3	IL10, CD4, CCR5, CCL2, CCR2, CXCR4
7	nervous system phenotype	MP:0003631	6.9	CD4, IL10, CCL2, CCR5, CCR2, CXCL12
8	cellular phenotype	MP:0005384	6.4	CD40, CD4, CXCL12, CCL2, CCR5, RNF2

Articles related to hiv-1, resistance to:

(show all 16)

id	Title	Authors	Year	Affiliating Genes
1	An HIV-1 resistance polymorphism in TRIM5I+ gene among Chinese intravenous drug users. (21107267)	Liu F.L.... Zheng Y.T.	2011	TRIM5
2	Identification of X-DING-CD4, a new member of human D ING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has a nti-viral activity. (19720052)	Lesner A.... Simm M.	2009	RNF2
3	Distribution of HIV-1 resistant polymorphisms among HIV infected patients in Georgia. (19124913)	Karchava M.... Tsertsvadze T.	2008	CCR5, CXCL12, CCR2
4	Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance. (18667075)	Tamhane M.... Akkina R.	2008	CXCR4, CCR5
5	Molecular analysis of the HIV-1 resistance developmen t: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-r esistant HIV protease mutants. (17977555)	KozA-sek M.... Konvalinka J.	2007	ERVK-6
6	Genetic basis of HIV-1 resistance and susceptibility: an approach to understand correlation between human genes and HIV-1 infection. (16999022)	Kumar V.... Medhi B.	2006	CCR5, IL10, CXCR6
7	A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer. (16081828)	Lesner A.... Simm M.	2005	CD40
8	Distribution of the HIV-1 resistance-conferring alleles (CCR5delta32, CCR2-64I, and SDF1 3'A) in Russian, Ukrainian, and Belarusian populations (15575507)	Kozhekbaeva G.M.... Iankovskii N.K.	2004	CCR5, CXCL12, CCR2
9	Reduced fitness of HIV-1 resistant to CXCR4 antagonists. (12713058)	Armand-Ugon M.... Este J.A.	2003	CXCR4, CD4
10	Distribution of two HIV-1-resistant polymorphisms (SDF1-3'A and CCR2-64I alleles) in the Polish population. (12436194)	Lewandowska M.... Jagodzinski P.P.	2002	CXCR4, CXCL12, CCR2
11	Distribution of HIV-1 resistance-conferring polymorphic alleles SDF-1-3'A, CCR2-64I and CCR5-Delta32 in diverse populations of Andhra Pradesh, South India. (11988632)	Ramana G.V.... Chakraborty R.	2001	CCR5, CXCL12, CCR2
12	Sequence and peptide-binding motif for a variant of HLA-A*0214 (A*02142) in an HIV-1-resistant individual from the Nairobi Sex Worker cohort. (11261925)	Luscher M.A.... Barber B.H.	2001	HLA-A
13	Genotypes and polymorphisms of mutant CCR5-delta 32, CCR2-64I and SDF1-3' a HIV-1 resistance alleles in indigenous Han Chinese. (11729511)	Wang F.... Li Y.	2001	CCR5, CXCL12, CCR2
14	Distribution of three HIV-1 resistance-conferring polymorphisms (SDF1-3'A, CCR2-641, and CCR5-delta32) in global populations. (11175286)	Su B.... Jin L.	2000	CXCR4, CCR5, CCR2
15	Provincial distribution of three HIV-1 resistant polymorphisms (CCR5-Delta32, CCR2-64I, and SDF1-3' A) in China. (18763111)	Xiao J.... Lu D.	2000	CCR5, CXCL12, CCR2
16	Distribution of two HIV-1-resistant polymorphisms (SDF1-3'A and CCR2-64I) in East Asian and world populations and its implication in AIDS epidemiology. (10486323)	Su B.... Chakraborty R.	1999	CXCL12, CCR2

Genes related to hiv-1, resistance to according to GeneCards:

(show all 14)

id	Symbol	Description	Score	GeneCards Section Context
1	CCL11	chemokine (C-C motif) ligand 11	11.0
2	CCL2	chemokine (C-C motif) ligand 2	11.0
3	CCR2	chemokine (C-C motif) receptor 2	11.0	Publications
4	TRIM5	tripartite motif containing 5	11.0	Publications
5	CXCR6	chemokine (C-X-C motif) receptor 6	11.0	Publications
6	ERVK-6	endogenous retrovirus group K, member 6	11.0	Publications
7	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
8	RNF2	ring finger protein 2	11.0	Publications
9	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications
10	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
11	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0	Publications
12	CD4	CD4 molecule	11.0	Publications
13	CXCR4	chemokine (C-X-C motif) receptor 4	11.0	Publications
14	IL10	interleukin 10	11.0	Publications

Pathways related to hiv-1, resistance to according to GeneDecks:

(show all 35)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.1	CCL11, CXCL12
2	Regulation of eIF4 and p70S6K36	9.8	CD4, CCL11
3	Molecular Mechanisms of Cancer36	9.6	CD4, CCL11, CXCL12
4	Asthma20	9.5	CD40, IL10, CCL11
5	MIF Mediated Glucocorticoid Regulation36	9.4	IL10, CCL11, CCL2, CXCL12
6	MIF Regulation of Innate Immune Cells36	9.4	CCL2, IL10, CCL11, CXCL12
7	Malaria20	9.4	IL10, CD40, CCL2
8	all-trans-Retinoic Acid Signaling in Brain36	9.4	CCL2, IL10, CXCL12, CCL11
9	PEDF Induced Signaling36	9.3	IL10, CCL2, CCL11, CXCL12
10	Allograft rejection20	9.3	CD40, IL10, HLA-A
11	IL-6 Pathway36	9.2	CCL2, IL10, CCL11, CXCL12
12	PGC1Alpha Pathway36	9.2	CCL11, CCL2, IL10, CD4
13	SOCS Pathway36	9.1	CCL11, CCL2, IL10, CD4
14	Autoimmune thyroid disease20	9.1	HLA-A, IL10, CD40
15	Endothelin-1 Signaling Pathway36	9.0	CXCL12, CCL2, IL10, CCL11
16	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	9.0	CCR5, CXCR4, CXCR6
17	PAK Pathway36	8.9	CCL11, IL10, CXCL12, CCL2
18	NF-kappaB Activation by Viruses36	8.9	CCR5, CD4, CXCR4
19	Apoptotic Pathways Triggered By HIV136	8.9	CD4, CCR5, CXCR4
20	JNK Pathway36	8.9	CD4, CXCL12, CCL11
21	Glucocorticoid Receptor Signaling36	8.9	CD4, CCL2, CCL11, IL10
22	NFAT Signaling and Lymphocyte Interactions36	8.8	CCL11, IL10, CCL2, CD4, CXCL12
23	TGF-Beta Pathway36	8.8	IL10, CCL2, CCL11, CXCL12, CD4
24	MAPK Family Pathway36	8.7	CCL2, CCL11, IL10, CD4, CXCL12
25	Intestinal immune network for IgA production20	8.6	CXCL12, IL10, CXCR4, CD40
26	Chemokine Signaling36	8.2	CCL2, CCR5, CCL11, CCR2, CXCR6, CXCL12
27	Chemokine signaling pathway20	8.2	CCL2, CCR2, CCR5, CXCR6, CXCR4, CXCL12
28	Transendothelial Migration of Leukocytes36	8.2	CCR2, CXCR6, CXCR4, CXCL12, CCR5, CCL11
29	JAK-STAT Pathway36	8.0	CD4, CCL11, CXCL12, CXCR4, IL10, CCL2
30	Akt Signaling36	7.3	IL10, CXCL12, CCL11, CXCR6, CCL2, CXCR4
31	Cytokine-cytokine receptor interaction20	7.2	CD40, IL10, CCR2, CCL2, CCL11, CCR5
32	STAT3 Pathway36	7.1	CCL2, CCL11, CXCR6, CXCR4, CXCL12, CCR5
33	Tec Kinases Signaling36	7.1	CXCR6, CCR5, CCL11, CCL2, CXCR4, CD4
34	Antioxidant Action of Vitamin-C36	7.1	CXCL12, CXCR6, CXCR4, CCR5, CD4, CCL2
35	p38 Signaling36	7.1	CCR2, CD4, CXCR4, CCR5, IL10, CCL2

Compounds related to hiv-1, resistance to according to GeneDecks:

(show top 50)    (show all 84)

id	Compound	Score	Top Affiliating Genes
1	rapamycin32 42	11.5	CCR5
2	bevirimat32	10.1	ERVK-6, CCR5
3	etravirine32	10.1	CCR5, ERVK-6
4	ly29400232	10.1	CCL2, IL10
5	pge232	10.0	CCL11, CD4
6	maraviroc32 34 42 9 9	14.0	ERVK-6, CCR5
7	rosmarinic acid32	9.9	CCL11, ERVK-6
8	shikonin32	9.8	CCR5, CCL2, CXCL12
9	ionomycin32	9.7	CCL11, CD40
10	mip 1alpha32	9.7	IL10, CCR5, CCL2
11	cgp6422232	9.6	CXCR4, ERVK-6
12	cyclam32	9.5	CXCR4, CXCL12
13	plerixafor32 9 9	11.4	CXCR4, CXCL12
14	sb 20358032 42	10.4	CCL11, CXCR4, CXCL12
15	tipranavir32 9 9	11.4	CXCR4, ERVK-6, CCR5
16	enfuvirtide32 9 9	11.4	CXCR4, ERVK-6, CCR5
17	bicyclam32	9.3	CXCL12, CXCR4, CCR5
18	anaphylatoxin32	9.2	CXCR4, CCL2, CXCL12
19	mcp 132	9.2	IL10, CXCR4, CCL2
20	il 1032	9.2	CD40, CCL2, IL10, CCR5
21	groalpha32	9.1	CCL2, IL10, CXCL12, CCL11, CCR5
22	pertussis32	9.1	CXCL12, CXCR4, CCL2, CCL11
23	c-d4i32	9.1	CD4, CCR5, CXCR4
24	simvastatin32 34 42 9 18 9	14.1	CD40, CCR5, CCL2, IL10
25	sdf 132	9.1	CCL2, CXCL12, CXCR4, CCR5
26	larc32	9.1	CCL2, CXCR4, CXCL12, CCR5
27	lipoteichoic acid32	9.0	CXCR4, CCL2, IL10
28	endotoxin32	9.0	CCL11, CD40, IL10, CCL2
29	ccl432	8.8	CXCR4, CCL2, CXCL12, CCR5, CCL11
30	quinine32 9 9	10.8	CXCR4, CCR5, IL10, CXCL12
31	galactosylceramide32	8.7	CXCR4, CXCL12, CCR5, CD4
32	genistein32 9 18 9	11.6	CD40, CD4, CCL2, CCL11, CXCL12
33	ccl332	8.3	CXCL12, IL10, CXCR4, CCL2, CCL11, CCR5
34	actinomycin d32	8.3	CCR5, CD40, CCL2, CXCR4, CXCL12, CCL11
35	histamine32 18	9.2	CXCR4, CCL11, CCL2, CCR5, IL10, CD40
36	polysaccharide32	8.1	CXCL12, CCR5, CCL2, CD4, CXCR4, ERVK-6
37	herbimycin a32 42	9.0	CCL11, CD4, CCL2, CXCR4, CD40, CXCL12
38	mdms32	8.0	CXCL12, CCR5, CCL2, CD4, IL10, CXCR4
39	vegf32	7.8	CXCR4, IL10, CD40, CCL11, CXCL12, CCL2
40	cholesterol32 9 18 9	10.8	CD4, CXCR4, CCL2, CCR5, CXCL12, CD40
41	arginine32	7.8	HLA-A, CCL2, CXCL12, CCR5, CXCR4, ERVK-6
42	dexamethasone32 42 34 9 9	11.7	IL10, CXCR4, CXCL12, CCR5, CCL11, CD40
43	tarc32	7.7	CCL11, CD4, CCL2, CCR5, CXCL12, CXCR4
44	cyclosporin a32 42	8.7	CXCR4, TRIM5, HLA-A, CCR5, IL10, CD40
45	cycloheximide32	7.7	CXCR4, IL10, CD40, CXCL12, CD4, CCL2
46	zidovudine32 9 9	9.6	ERVK-6, CXCL12, CCR5, CCL2, CXCR4, CD4
47	phosphatidylinositol32	7.3	CCL2, CD4, CXCR4, CCL11, CXCL12, CD40
48	tyrosine32	7.0	HLA-A, CCR5, ERVK-6, CCL11, CD40, CXCR4
49	rantes32	6.9	CXCR4, CCR5, CD4, CCL11, CCL2, IL10
50	calcium32 9 18 9	9.6	CCL11, CD40, CXCR6, CXCR4, CCL2, HLA-A

Cellular components related to hiv-1, resistance to according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	7.8	CD4, CD40, CCR5, CXCL12, CXCR4

Biological processes related to hiv-1, resistance to according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of immune complex clearance by monocytes and macrophages	GO:090265	10.3	CCR2, CCL2
2	regulation of vascular endothelial growth factor production	GO:010574	10.2	CCR2, CCL2
3	cellular homeostasis	GO:019725	10.1	CCR2, CCL2
4	positive regulation of monocyte chemotaxis	GO:090026	10.0	CCR2, CXCL12
5	viral genome replication	GO:019079	9.9	CXCR6, CCL2
6	positive regulation of endothelial cell proliferation	GO:001938	9.8	CCL11, CCL2, CXCL12
7	positive regulation of T cell activation	GO:050870	9.7	CCL2, CCR2
8	positive regulation of Rac GTPase activity	GO:032855	9.6	CCL11, CD40
9	cellular response to lipopolysaccharide	GO:071222	9.6	IL10, CCL2, CCR5
10	B cell proliferation	GO:042100	9.6	IL10, CD40
11	chemokine-mediated signaling pathway	GO:070098	9.6	CXCL12, CCR5, CCL2, CCR2
12	ameboidal cell migration	GO:001667	9.5	CXCR4, CXCL12
13	germ cell migration	GO:008354	9.4	CXCL12, CXCR4
14	dendritic cell chemotaxis	GO:002407	9.4	CXCR4, CCR5, CCR2
15	chemotaxis	GO:006935	9.3	CXCL12, CCR5, CCL11, CCL2, CCR2
16	T cell proliferation	GO:042098	9.2	CXCR4, CXCL12
17	cellular calcium ion homeostasis	GO:006874	9.1	CCR2, CD40, CCL2, CCL11, CXCL12
18	elevation of cytosolic calcium ion concentration	GO:007204	9.1	CXCR4, CCR2, CCR5
19	entry into host cell	GO:030260	9.0	CXCR4, CD4, CCR5
20	response to virus	GO:009615	9.0	CCL11, CXCR4, CXCL12, TRIM5
21	G-protein coupled receptor signaling pathway	GO:007186	8.7	CXCR6, CXCR4, CXCL12, CCR5, CCL2
22	virus-host interaction	GO:019048	8.6	CCR5, HLA-A, TRIM5, CCR2, CXCR4
23	immune response	GO:006955	8.5	CXCL12, HLA-A, CCR5, CCL11, CCR2, CD4
24	viral reproduction	GO:016032	8.2	CXCR4, CD4, CCR5, ERVK-6, HLA-A
25	inflammatory response	GO:006954	7.9	CCR2, IL10, CCL2, CCL11, CCR5, CXCR4

Molecular functions related to hiv-1, resistance to according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	CCR2 chemokine receptor binding	GO:031727	10.0	CCR2, CCL2
2	chemokine receptor activity	GO:004950	9.9	CCR5, CCR2
3	chemokine activity	GO:008009	9.6	CXCL12, CCL11, CCL2
4	C-C chemokine receptor activity	GO:016493	9.6	CCR2, CCR5
5	C-X-C chemokine receptor activity	GO:016494	9.3	CXCR4, CXCR6
6	coreceptor activity	GO:015026	8.5	CXCR4, CXCR6, CCR5, CD4