MCID: HV1005
MIFTS: 42

Hiv-1 Viremia malady

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Summaries for Hiv-1 Viremia

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MalaCards based summary: Hiv-1 Viremia is related to hiv-1 and blau syndrome. An important gene associated with Hiv-1 Viremia is HLA-C (major histocompatibility complex, class I, C), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and A-beta Uptake and Degradation. The compounds tak-779 and ccl2 have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are respiratory system and no phenotypic analysis.

Description from OMIM:46 609423

Aliases & Classifications for Hiv-1 Viremia

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Hiv-1 Viremia, Aliases & Descriptions:

Name: Hiv-1 Viremia 46


Related Diseases for Hiv-1 Viremia

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Diseases related to Hiv-1 Viremia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1hiv-110.9
2blau syndrome10.5TNF
3intraocular lymphoma10.5IL10
4corneal ulcer10.5CCL11
5leishmaniasis10.4IL10
6asthma10.3TNF, CCL11
7acute graft versus host disease10.3IL10, TNF
8psoriatic arthritis10.3TNF, HLA-C
9alcoholic hepatitis10.3CCL2, TNF
10cerebral malaria10.3IL10, TNF
11ankylosing spondylitis10.3TNF, HLA-C
12malaria10.3IL10, TNF, HDAC9
13periapical granuloma10.3CCR5, CCL2
14galactosemia10.2IL10, TNF, HLA-C
15interstitial lung disease10.2CCL2, CCL11
16demyelinating disease10.2IL10, CCL2, TNF
17membranous glomerulonephritis10.2CCR5, CCL2
18retinitis10.2
19congenital heart disease10.2IL10, CCL2, TNF
20behcet's disease10.2HLA-C, TNF, CCR5
21pulmonary tuberculosis10.1IL10, CXCL12
22allergic asthma10.1IL10, CCL11, CCL2
23tuberculosis10.1IL10, CXCL12, TNF
24pulmonary sarcoidosis10.1TNF, CCL2, CCR5
25schistosomiasis10.1IL10, CCR5
26myeloma10.1CXCL12, HDAC9
27monocytic leukemia10.1TNF, CXCL12, CCL2
28lupus nephritis10.1CCL2, CCR5, IL10
29squamous cell carcinoma of the head and neck10.1HDAC9, CXCL12, CCL2
30aids dementia complex10.1TNF, CXCL12, CCR5
31skin disease10.1IL10, CCL11, TNF, HLA-C
32connective tissue disease10.1IL10, CCL2, TNF, HLA-C
33hypersensitivity reaction type ii disease10.1HLA-C, TNF, CCL2, IL10
34central nervous system disease10.1CCL2, CCR5
35atopic dermatitis10.0TNF, CCL2, CCL11, IL10
36chronic lymphocytic leukemia10.0HDAC9, CXCL12, CCR5
37vascular disease10.0HLA-C, TNF, CXCL12, IL10
38acquired immunodeficiency syndrome10.0CCR5, CCR2, CXCL12
39coronary artery anomaly10.0CCL2, CCR5, CCL11
40periodontitis10.0TNF, CCL2, CCR5, IL10
41encephalitis10.0TLR3, CCL2, CCR5
42systemic lupus erythematosus10.0TNF, CCL2, CCR5, IL10
43influenza9.9TLR3, CCR5, CCL11
44ulcerative colitis9.9TLR3, TNF, CCL11, IL10
45hepatitis9.9CCL11, CXCL12, TLR3
46graft versus host disease9.9TNF, CXCL12, CCR5, IL10
47proliferative diabetic retinopathy9.9CCL2, CXCL12
48psoriasis9.9HLA-C, TNF, CCL2, CCL11, IL10
49immunodeficiency with hyper igm type 29.9HLA-C, CXCL12, CCR5, CCL11
50hepatitis c9.9TLR3, TNF, CCR5, IL10

Graphical network of the top 20 diseases related to Hiv-1 Viremia:



Diseases related to hiv-1 viremia

Symptoms for Hiv-1 Viremia

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Clinical features from OMIM:

609423

Drugs & Therapeutics for Hiv-1 Viremia

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Drug clinical trials:

Search ClinicalTrials for Hiv-1 Viremia

Search NIH Clinical Center for Hiv-1 Viremia

Genetic Tests for Hiv-1 Viremia

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Anatomical Context for Hiv-1 Viremia

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MalaCards organs/tissues related to Hiv-1 Viremia:

32
T cells

Animal Models for Hiv-1 Viremia or affiliated genes

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Publications for Hiv-1 Viremia

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Articles related to Hiv-1 Viremia:

(show all 28)
idTitleAuthorsYear
1
Absence of Detectible HIV-1 Viremia After Treatment Cessation in an Infant. (25363994)
2014
2
Impaired Nef function is associated with early control of HIV-1 viremia. (24965469)
2014
3
Incomplete adherence to antiretroviral therapy is associated with higher levels of residual HIV-1 viremia. (24361679)
2014
4
Impact of maternal HIV-1 viremia on lymphocyte subsets among HIV-exposed uninfected infants: protective mechanism or immunodeficiency. (24885498)
2014
5
Improved Single-Copy Assays for Quantification of Persistent HIV-1 Viremia in Patients on Suppressive Antiretroviral Therapy. (25187636)
2014
6
Antiretroviral treatment switch strategies for lowering the costs of antiretroviral therapy in subjects with suppressed HIV-1 viremia in Spain. (23723714)
2013
7
Absence of detectable HIV-1 viremia after treatment cessation in an infant. (24152233)
2013
8
Intermittent HIV-1 viremia (blips) and virological failure in a cohort of people living with HIV from SALo Paulo, Brazil. (22916841)
2012
9
Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells. (21367910)
2011
10
High clade C HIV-1 viremia: how did we get here and where are we going? (21747235)
2011
11
Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection. (19910789)
2010
12
Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection. (20186346)
2010
13
Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2-/-{gamma}c-/- mouse. (19494021)
2009
14
The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. (19710502)
2009
15
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. (19470482)
2009
16
Long-term follow-up of patients taking tenofovir DF with low-level HIV-1 viremia and the K65R substitution in HIV-1 RT. (17413698)
2007
17
Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T(EMRA) cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point. (17376902)
2007
18
HIV-1 viremia during the first 28 weeks of pregnancy is not associated with mother-to-child transmission. (17293908)
2006
19
Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. (16028129)
2005
20
Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART. (15713771)
2005
21
HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. (14676302)
2003
22
The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia. (14517700)
2003
23
The loss of CMV-specific CD27(-) T-cell effectors in a patient with recurrences of CMV retinitis is independent of HIV-1 viremia. (12382097)
2002
24
High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferation. (11717444)
2001
25
Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity. (11309482)
2001
26
Prolonged suppression of human immunodeficiency virus type 1 (HIV-1) viremia in persons with advanced disease results in enhancement of CD4 T cell reactivity to microbial antigens but not to HIV-1 antigens. (9878015)
1999
27
Human immunodeficiency virus type 1 (HIV-1) viremia changes and development of drug-related mutations in patients with symptomatic HIV-1 infection receiving alternating or simultaneous zidovudine and didanosine therapy. (7751690)
1995
28
Plasma HIV-1 viremia in HIV-1 infected individuals assessed by polymerase chain reaction. (1520538)
1992

Variations for Hiv-1 Viremia

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Clinvar genetic disease variations for Hiv-1 Viremia:

6 (show all 11)
id Gene Name Type Significance SNP ID Assembly Location
1CCL2CCL2, -2136A-Tsingle nucleotide variantPathogenic
2CCL2CCL2, 767C-Gsingle nucleotide variantPathogenic
3IL10IL10, -592C-Asingle nucleotide variantPathogenic
4TLR3NM_003265.2(TLR3): c.1234C> T (p.Leu412Phe)single nucleotide variantPathogenicrs3775291GRCh37Chr 4, 187004074: 187004074
5NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs)deletionPathogenicrs333GRCh37Chr 3, 46414947: 46414978
6NM_000579.3(CCR5): c.303T> A (p.Cys101Ter)single nucleotide variantPathogenicrs1800560GRCh37Chr 3, 46414696: 46414696
7NM_000579.3(CCR5): c.180G> T (p.Arg60Ser)single nucleotide variantPathogenicrs1800940GRCh37Chr 3, 46414573: 46414573
8CCR5CCR5, 2459A-Gsingle nucleotide variantPathogenic
9CCR2NM_001123041.2(CCR2): c.190G> A (p.Val64Ile)single nucleotide variantPathogenicrs1799864GRCh37Chr 3, 46399208: 46399208
10CCL11CCL11, -1385G-Asingle nucleotide variantPathogenic
11CXCL12NM_000609.6(CXCL12): c.266+535G> Asingle nucleotide variantPathogenicrs387906400GRCh37Chr 10, 44873550: 44873550

Expression for genes affiliated with Hiv-1 Viremia

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Expression patterns in normal tissues for genes affiliated with Hiv-1 Viremia

Search GEO for disease gene expression data for Hiv-1 Viremia.

Pathways for genes affiliated with Hiv-1 Viremia

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Pathways related to Hiv-1 Viremia according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CCL11, CCL2
29.9CCL2, CCR2
39.5CXCL12, CCR2, IL10
49.4IL10, TNF
59.4TNF, IL10
69.4IL10, TNF
7
Show member pathways
9.4IL10, TNF
89.4IL10, TNF
99.4TNF, CCL2
109.1CCR5, HLA-C, HDAC9
11
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1IL10, CCL2, TNF
129.1IL10, CCL2, TNF
139.0TNF, CCR2, CCL2
149.0CCL2, CCR2, TNF
15
Show member pathways
9.0TNF, TLR3, HLA-C
16
Show member pathways
IL27-mediated signaling events37
9.0TLR3, TNF, IL10
179.0CCL2, CXCL12, TNF
18
Show member pathways
8.9TLR3, TNF, CXCL12
19
Show member pathways
8.9TNF, CCR5, IL10
20
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.9IL10, CCR5, TNF
21
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.9CCR5, CCL2, TNF
22
Show member pathways
Immune response CD16 signaling in NK cells60
8.9MICA, TNF, HLA-C
23
Show member pathways
8.8CCL11, CCR5, CCL2, CCR2, CXCL12
24
Show member pathways
8.8CXCL12, CCR2, CCL2, CCR5, CCL11
25
Show member pathways
8.8CXCL12, CCR2, CCL2, CCR5, CCL11
26
Show member pathways
8.8CXCL12, CCR2, CCL2, CCR5, CCL11
278.8IL10, TNF, HDAC9
28
Show member pathways
8.7HLA-C, TLR3, TNF, CCL2
29
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.7TLR3, TNF, CCL2, IL10
30
Show member pathways
8.5IL10, CCL11, CCL2, CXCL12, TNF
31
Show member pathways
8.1HDAC9, CXCL12, CCR2, CCL2, CCR5, CCL11
32
Show member pathways
8.0HLA-C, TNF, CXCL12, CCL11, MICA, IL10
33
Show member pathways
7.7TNF, CXCL12, CCR2, CCL2, CCR5, CCL11
34
Show member pathways
7.7TNF, CXCL12, CCR2, CCL2, CCR5, CCL11
35
Show member pathways
7.3IL10, TLR3, TNF, CXCL12, CCR2, CCL2
36
Show member pathways
7.1HDAC9, TNF, CXCL12, CCR2, CCL2, CCR5

Compounds for genes affiliated with Hiv-1 Viremia

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Compounds related to Hiv-1 Viremia according to GeneCards/GeneDecks:

(show top 50)    (show all 128)
idCompoundScoreTop Affiliating Genes
1tak-7792810.0CCR5, CCR2
2ccl2289.9CCR2, CCR5
3bicyclam449.9CXCL12, CCR5
4ccl8289.8CCR5, CCR2
5ccl11289.8CCR5, CCR2
6sdf 1449.8CCL2, CCR5, CXCL12
7shikonin449.8CCR5, CXCL12, CCL2
8pertussis449.8CXCL12, CCL2, CCL11
9ccl16289.8CCR2, CCR5
10larc449.8CCR5, CCL2, CXCL12
11mdms449.5CCL2, CXCL12, CCR5, IL10
12zidovudine44 50 1111.5IL10, CXCL12, CCL2, CCR5
13ccl444 2810.5CCR5, CXCL12, CCL2, CCL11
14toxin-1449.5IL10, CCL2, TNF
155 aminosalicylic acid449.5IL10, CCL2, TNF
16il-12449.5CCL2, TNF, IL10
17polymyxin b449.4TNF, CCL2, IL10
18gm-csf44 2810.4TNF, CCL2, IL10
198-isoprostane449.4CCL2, IL10, TNF
20imiquimod44 61 28 1112.4IL10, TNF, TLR3
21rolipram44 61 2811.4CCL11, IL10, TNF
22polyinosinic-polycytidylic acid449.3TLR3, IL10, TNF
232,5-oligoadenylate449.3IL10, TNF, TLR3
2415-deoxy-delta-12,14-prostaglandin j2449.2CCL11, IL10, TNF, CCL2
25poly(i-c)449.2TLR3, CCL11, TNF
26peptidoglycan44 2810.1IL10, CCL11, TNF, TLR3
27lipoteichoic acid449.1TLR3, IL10, CCL2, TNF
28quinine44 28 2 50 1113.1CXCL12, CCR5, IL10
29herbimycin a44 6110.1TNF, CCL2, CCL11, CXCL12
30mip 1alpha449.1CCR5, TNF, CCL2, IL10
31il 10449.0CCR5, CCL2, IL10, TNF
32fmlp449.0CCL11, CCL2, CXCL12, TNF
33n-formylmethionyl-leucylphenylalanine449.0CCL11, CXCL12, TNF
34simvastatin44 50 61 28 24 1114.0IL10, CCR5, CCL2, TNF
35endotoxin448.9IL10, TLR3, TNF, CCL2, CCL11
36ivig448.8CCR5, TNF, IL10
37tgf beta1448.8IL10, TNF, CCL2, HDAC9
38histamine44 28 2410.7CCR5, IL10, CCL11, CCL2, TNF
39actinomycin d448.7CCR5, CCL2, CXCL12, TNF, CCL11
40groalpha448.5CCL11, CCR5, IL10, CCL2, CXCL12, TNF
41tarc448.5CXCL12, TNF, CCL2, CCR5, CCL11, IL10
42ccl344 289.4CXCL12, TNF, CCL2, IL10, CCL11, CCR5
43n acetylcysteine448.4CCL11, CCL2, TNF, HDAC9
44sb 20358044 619.3CCL2, CCL11, CXCL12, IL10, TNF, HDAC9
45vegf448.2CXCL12, IL10, CCL11, CCL2, HDAC9, TNF
46nitric oxide44 24 1110.2TLR3, TNF, CCL11, HDAC9, CCL2, IL10
47rantes448.1CCR5, CCL2, CXCL12, TNF, TLR3, IL10
48ly294002447.9CCL11, IL10, CCL2, TNF, TLR3, HDAC9
49pge2447.8HDAC9, TNF, CXCL12, CCL2, CCL11, IL10
50dexamethasone44 50 28 1110.4IL10, HDAC9, TLR3, CCL11, CCR5, TNF

GO Terms for genes affiliated with Hiv-1 Viremia

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Cellular components related to Hiv-1 Viremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6TNF, CXCL12, CCR5
2extracellular regionGO:0055768.5CCL11, CCL2, CXCL12, TNF, HLA-C
3cell surfaceGO:0099868.0HLA-C, TLR3, TNF, CCR5, MICA
4extracellular spaceGO:0056157.8TNF, CXCL12, CCL2, CCL11, MICA, IL10
5integral component of plasma membraneGO:0058876.9SIGLEC7, TUSC3, HLA-C, TLR3, TNF, CCR2

Biological processes related to Hiv-1 Viremia according to GeneCards/GeneDecks:

(show all 44)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immune complex clearance by monocytes and macrophagesGO:09026510.3CCL2, CCR2
2regulation of vascular endothelial growth factor productionGO:01057410.3CCL2, CCR2
3cellular homeostasisGO:01972510.2CCR2, CCL2
4positive regulation of T cell activationGO:05087010.2CCL2, CCR2
5response to radiationGO:00931410.1CXCL12, CCL11
6cellular response to interferon-gammaGO:07134610.1CCL2, TLR3
7JAK-STAT cascadeGO:00725910.1CCL2, CCR2
8dendritic cell chemotaxisGO:00240710.0CCR2, CCR5
9positive regulation of endothelial cell proliferationGO:0019389.9CXCL12, CCL2, CCL11
10cellular response to lipopolysaccharideGO:0712229.8CCL2, CCR5, IL10
11receptor biosynthetic processGO:0328009.8TNF, IL10
12positive regulation of monocyte chemotaxisGO:0900269.8CCR5, CCR2, CXCL12
13negative regulation of cytokine secretion involved in immune responseGO:0027409.8IL10, TNF
14response to heatGO:0094089.7MICA, CCL2, CXCL12
15cytokine-mediated signaling pathwayGO:0192219.7CCL2, CCR2, HLA-C
16positive regulation of synaptic transmissionGO:0508069.7TNF, CCL2
17negative regulation of growth of symbiont in hostGO:0441309.7IL10, TNF
18defense response to bacteriumGO:0427429.7IL10, MICA, TLR3
19necroptotic signaling pathwayGO:0975279.7TNF, TLR3
20negative regulation of interleukin-6 productionGO:0327159.7IL10, TNF
21positive regulation of chemokine biosynthetic processGO:0450809.7TLR3, TNF
22cellular calcium ion homeostasisGO:0068749.7CXCL12, CCR2, CCL2, CCL11
23positive regulation of chemokine productionGO:0327229.6TNF, TLR3
24positive regulation of cytokine secretionGO:0507159.6IL10, TNF
25blood vessel remodelingGO:0019749.6CCR2, CCR5
26positive regulation of NF-kappaB import into nucleusGO:0423469.6TNF, TLR3
27lipopolysaccharide-mediated signaling pathwayGO:0316639.5CCL2, TNF
28response to activityGO:0148239.5TNF, CCL2, IL10
29protein kinase B signalingGO:0434919.5TNF, CCL2
30chemokine-mediated signaling pathwayGO:0700989.5CCR5, CCL2, CCR2, CXCL12
31response to glucocorticoidGO:0513849.5IL10, CCL2, TNF
32cellular response to organic cyclic compoundGO:0714079.4CCL2, TNF
33response to mechanical stimulusGO:0096129.4CCL2, CXCL12, TNF
34response to virusGO:0096159.4CCL11, CXCL12, TNF
35cell adhesionGO:0071559.4SIGLEC7, CCL11, CCL2, CXCL12
36response to hypoxiaGO:0016669.3TNF, CXCL12, CCL2
37MAPK cascadeGO:0001659.3CCR5, CCL2, TNF
38extrinsic apoptotic signaling pathwayGO:0971919.3TLR3, TNF
39positive regulation of interleukin-6 productionGO:0327559.3TNF, TLR3
40immune responseGO:0069559.2CCL11, CCR5, CCR2, CXCL12, HLA-C
41viral processGO:0160329.2HLA-C, CCR2, CCR5, MICA
42chemotaxisGO:0069359.2CXCL12, CCR2, CCL2, CCR5, CCL11
43positive regulation of interferon-gamma productionGO:0327299.0CCR2, TNF
44inflammatory responseGO:0069547.5IL10, HDAC9, TLR3, TNF, CCR2, CCL2

Molecular functions related to Hiv-1 Viremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR2 chemokine receptor bindingGO:0317279.8CCL2, CCR2
2chemokine receptor activityGO:0049509.7CCR5, CCR2
3chemokine activityGO:0080099.5CCL11, CCL2, CXCL12
4C-C chemokine receptor activityGO:0164939.4CCR5, CCR2

Products for genes affiliated with Hiv-1 Viremia

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Sources for Hiv-1 Viremia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet