Summaries for Hiv-1 Viremia

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MalaCards based summary: Hiv-1 Viremia is related to hiv-1 and blau syndrome. An important gene associated with Hiv-1 Viremia is HLA-C (major histocompatibility complex, class I, C), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and A-beta Uptake and Degradation. The compounds tak-779 and ccl2 have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are respiratory system and no phenotypic analysis.

Description from OMIM:46 609423

Aliases & Classifications for Hiv-1 Viremia

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Hiv-1 Viremia, Aliases & Descriptions:

Name: Hiv-1 Viremia 46


Related Diseases for Hiv-1 Viremia

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Diseases related to Hiv-1 Viremia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1hiv-110.9
2blau syndrome10.5TNF
3intraocular lymphoma10.5IL10
4corneal ulcer10.5CCL11
5leishmaniasis10.4IL10
6ulcerative colitis10.3TNF
7asthma10.3CCL11, TNF
8psoriatic arthritis10.3TNF, HLA-C
9acute graft versus host disease10.3TNF, IL10
10ankylosing spondylitis10.3TNF, HLA-C
11cerebral malaria10.3IL10, TNF
12alcoholic hepatitis10.3CCL2, TNF
13periapical granuloma10.2CCL2, CCR5
14malaria10.2IL10, TNF, HDAC9
15interstitial lung disease10.2CCL2, CCL11
16galactosemia10.2TNF, IL10, HLA-C
17retinitis10.2
18membranous glomerulonephritis10.2CCL2, CCR5
19demyelinating disease10.2TNF, CCL2, IL10
20schistosomiasis10.2IL10, CCR5
21behcet's disease10.1CCR5, HLA-C, TNF
22congenital heart disease10.1TNF, CCL2, IL10
23pulmonary tuberculosis10.1CXCL12, IL10
24allergic asthma10.1CCL2, IL10, CCL11
25myeloma10.1CXCL12, HDAC9
26pulmonary sarcoidosis10.1CCL2, CCR5, TNF
27central nervous system disease10.1CCR5, CCL2
28tuberculosis10.1IL10, CXCL12, TNF
29lupus nephritis10.1IL10, CCR5, CCL2
30monocytic leukemia10.0CCL2, CXCL12, TNF
31hepatitis b10.0CCR5, IL10
32aids dementia complex10.0CXCL12, TNF, CCR5
33skin disease10.0IL10, TNF, CCL11, HLA-C
34squamous cell carcinoma of the head and neck10.0HDAC9, CXCL12, CCL2
35connective tissue disease10.0HLA-C, TNF, CCL2, IL10
36hypersensitivity reaction type ii disease10.0IL10, HLA-C, TNF, CCL2
37proliferative diabetic retinopathy10.0CXCL12, CCL2
38chronic lymphocytic leukemia10.0CCR5, HDAC9, CXCL12
39coronary artery anomaly10.0CCL2, CCL11, CCR5
40atopic dermatitis10.0CCL2, TNF, IL10, CCL11
41myasthenia gravis9.9IL10, CCR5
42periodontitis9.9TNF, CCL2, IL10, CCR5
43vascular disease9.9CXCL12, TNF, IL10, HLA-C
44acquired immunodeficiency syndrome9.9CXCL12, CCR5, CCR2
45systemic lupus erythematosus9.9CCR5, CCL2, TNF, IL10
46myocardial infarction9.9CCL11, CXCL12, CCR5
47graft versus host disease9.9IL10, TNF, CXCL12, CCR5
48encephalitis9.9TLR3, CCL2, CCR5
49influenza9.8TLR3, CCR5, CCL11
50psoriasis9.8CCL11, IL10, CCL2, HLA-C, TNF

Graphical network of the top 20 diseases related to Hiv-1 Viremia:



Diseases related to hiv-1 viremia

Symptoms for Hiv-1 Viremia

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Clinical features from OMIM:

609423

Drugs & Therapeutics for Hiv-1 Viremia

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Drug clinical trials:

Search ClinicalTrials for Hiv-1 Viremia

Search NIH Clinical Center for Hiv-1 Viremia

Genetic Tests for Hiv-1 Viremia

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Anatomical Context for Hiv-1 Viremia

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MalaCards organs/tissues related to Hiv-1 Viremia:

32
T cells

Animal Models for Hiv-1 Viremia or affiliated genes

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Publications for Hiv-1 Viremia

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Articles related to Hiv-1 Viremia:

(show all 28)
idTitleAuthorsYear
1
Absence of Detectible HIV-1 Viremia After Treatment Cessation in an Infant. (25363994)
2014
2
Impaired Nef function is associated with early control of HIV-1 viremia. (24965469)
2014
3
Incomplete adherence to antiretroviral therapy is associated with higher levels of residual HIV-1 viremia. (24361679)
2014
4
Impact of maternal HIV-1 viremia on lymphocyte subsets among HIV-exposed uninfected infants: protective mechanism or immunodeficiency. (24885498)
2014
5
Improved Single-Copy Assays for Quantification of Persistent HIV-1 Viremia in Patients on Suppressive Antiretroviral Therapy. (25187636)
2014
6
Antiretroviral treatment switch strategies for lowering the costs of antiretroviral therapy in subjects with suppressed HIV-1 viremia in Spain. (23723714)
2013
7
Absence of detectable HIV-1 viremia after treatment cessation in an infant. (24152233)
2013
8
Intermittent HIV-1 viremia (blips) and virological failure in a cohort of people living with HIV from SALo Paulo, Brazil. (22916841)
2012
9
Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells. (21367910)
2011
10
High clade C HIV-1 viremia: how did we get here and where are we going? (21747235)
2011
11
Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection. (19910789)
2010
12
Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection. (20186346)
2010
13
Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2-/-{gamma}c-/- mouse. (19494021)
2009
14
The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. (19710502)
2009
15
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. (19470482)
2009
16
Long-term follow-up of patients taking tenofovir DF with low-level HIV-1 viremia and the K65R substitution in HIV-1 RT. (17413698)
2007
17
Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T(EMRA) cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point. (17376902)
2007
18
HIV-1 viremia during the first 28 weeks of pregnancy is not associated with mother-to-child transmission. (17293908)
2006
19
Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. (16028129)
2005
20
Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART. (15713771)
2005
21
HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. (14676302)
2003
22
The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia. (14517700)
2003
23
The loss of CMV-specific CD27(-) T-cell effectors in a patient with recurrences of CMV retinitis is independent of HIV-1 viremia. (12382097)
2002
24
High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferation. (11717444)
2001
25
Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity. (11309482)
2001
26
Prolonged suppression of human immunodeficiency virus type 1 (HIV-1) viremia in persons with advanced disease results in enhancement of CD4 T cell reactivity to microbial antigens but not to HIV-1 antigens. (9878015)
1999
27
Human immunodeficiency virus type 1 (HIV-1) viremia changes and development of drug-related mutations in patients with symptomatic HIV-1 infection receiving alternating or simultaneous zidovudine and didanosine therapy. (7751690)
1995
28
Plasma HIV-1 viremia in HIV-1 infected individuals assessed by polymerase chain reaction. (1520538)
1992

Variations for Hiv-1 Viremia

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Clinvar genetic disease variations for Hiv-1 Viremia:

7 (show all 11)
id Gene Name Type Significance SNP ID Assembly Location
1CCL2CCL2, -2136A-Tsingle nucleotide variantPathogenic
2CCL2CCL2, 767C-Gsingle nucleotide variantPathogenic
3IL10IL10, -592C-Asingle nucleotide variantPathogenic, risk factor
4TLR3NM_003265.2(TLR3): c.1234C> T (p.Leu412Phe)single nucleotide variantPathogenicrs3775291GRCh37Chr 4, 187004074: 187004074
5NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs)deletionPathogenic, risk factorrs333GRCh37Chr 3, 46414947: 46414978
6NM_000579.3(CCR5): c.303T> A (p.Cys101Ter)single nucleotide variantPathogenicrs1800560GRCh37Chr 3, 46414696: 46414696
7NM_000579.3(CCR5): c.180G> T (p.Arg60Ser)single nucleotide variantPathogenicrs1800940GRCh37Chr 3, 46414573: 46414573
8CCR5CCR5, 2459A-Gsingle nucleotide variantPathogenic
9CCR2NM_001123041.2(CCR2): c.190G> A (p.Val64Ile)single nucleotide variantPathogenicrs1799864GRCh37Chr 3, 46399208: 46399208
10CCL11CCL11, -1385G-Asingle nucleotide variantPathogenic
11CXCL12NM_000609.6(CXCL12): c.266+535G> Asingle nucleotide variantPathogenicrs387906400GRCh37Chr 10, 44873550: 44873550

Expression for genes affiliated with Hiv-1 Viremia

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Expression patterns in normal tissues for genes affiliated with Hiv-1 Viremia

Search GEO for disease gene expression data for Hiv-1 Viremia.

Pathways for genes affiliated with Hiv-1 Viremia

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Pathways related to Hiv-1 Viremia according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CCL11, CCL2
29.8CCL2, CCR2
39.5IL10, CCR2, CXCL12
49.4TNF, IL10
59.4TNF, IL10
69.4IL10, TNF
7
Show member pathways
9.4IL10, TNF
89.4IL10, TNF
99.3CCL2, TNF
10
Show member pathways
9.2CCL11, CXCL12, HDAC9
119.1CCR5, HLA-C, HDAC9
12
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.0IL10, CCL2, TNF
139.0TNF, CCL2, IL10
149.0CCL2, CCR2, TNF
159.0CCL2, CCR2, TNF
16
Show member pathways
9.0HLA-C, TLR3, TNF
17
Show member pathways
IL27-mediated signaling events37
9.0TLR3, TNF, IL10
189.0TNF, CXCL12, CCL2
19
Show member pathways
8.9IL10, CCR5, TNF
20
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.9TNF, CCR5, IL10
21
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.9TNF, CCL2, CCR5
22
Show member pathways
8.9CXCL12, TNF, TLR3
23
Show member pathways
Immune response CD16 signaling in NK cells59
8.9MICA, TNF, HLA-C
248.7IL10, TNF, HDAC9
25
Show member pathways
8.7CXCL12, CCR2, CCL2, CCR5, CCL11
26
Show member pathways
8.7CXCL12, CCR2, CCL2, CCR5, CCL11
27
Show member pathways
8.7CXCL12, CCR2, CCL2, CCR5, CCL11
28
Show member pathways
8.7CXCL12, CCR2, CCL2, CCR5, CCL11
29
Show member pathways
8.7CCL2, TNF, TLR3, HLA-C
30
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.6IL10, CCL2, TNF, TLR3
31
Show member pathways
8.4IL10, CCL11, CCL2, CXCL12, TNF
32
Show member pathways
8.1HDAC9, CXCL12, CCR2, CCL2, CCR5, CCL11
33
Show member pathways
7.9HLA-C, TNF, CXCL12, CCL11, MICA, IL10
34
Show member pathways
7.6TNF, CXCL12, CCR2, CCL2, CCR5, CCL11
35
Show member pathways
7.6TNF, CXCL12, CCR2, CCL2, CCR5, CCL11
36
Show member pathways
7.2IL10, TLR3, TNF, CXCL12, CCR2, CCL2
37
Show member pathways
7.0HDAC9, TNF, CXCL12, CCR2, CCL2, CCR5

Compounds for genes affiliated with Hiv-1 Viremia

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Compounds related to Hiv-1 Viremia according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1tak-7792910.0CCR5, CCR2
2ccl2299.9CCR2, CCR5
3bicyclam449.8CCR5, CXCL12
4ccl8299.8CCR2, CCR5
5ccl11299.8CCR5, CCR2
6sdf 1449.7CCL2, CCR5, CXCL12
7ccl16299.7CCR2, CCR5
8shikonin449.7CCR5, CXCL12, CCL2
9larc449.7CXCL12, CCR5, CCL2
10pertussis449.7CXCL12, CCL2, CCL11
11mdms449.5CCL2, CXCL12, CCR5, IL10
12toxin-1449.5IL10, CCL2, TNF
13zidovudine44 50 1211.4IL10, CXCL12, CCL2, CCR5
14ccl444 2910.4CCR5, CXCL12, CCL2, CCL11
155 aminosalicylic acid449.4CCL2, IL10, TNF
16il-12449.4TNF, CCL2, IL10
17polymyxin b449.4TNF, CCL2, IL10
18quinine44 29 3 50 1213.4CXCL12, IL10, CCR5
19gm-csf44 2910.4IL10, CCL2, TNF
208-isoprostane449.3TNF, CCL2, IL10
21rolipram44 60 2911.3TNF, CCL11, IL10
22imiquimod44 60 29 1212.3IL10, TNF, TLR3
232,5-oligoadenylate449.2TLR3, TNF, IL10
24polyinosinic-polycytidylic acid449.2IL10, TNF, TLR3
25poly(i-c)449.2TLR3, TNF, CCL11
2615-deoxy-delta-12,14-prostaglandin j2449.2CCL11, IL10, TNF, CCL2
27peptidoglycan44 2910.1IL10, CCL11, TNF, TLR3
28lipoteichoic acid449.1TLR3, IL10, CCL2, TNF
29mip 1alpha449.0CCR5, TNF, CCL2, IL10
30il 10449.0CCR5, CCL2, IL10, TNF
31herbimycin a44 6010.0CCL11, CXCL12, TNF, CCL2
32n-formylmethionyl-leucylphenylalanine449.0CXCL12, TNF, CCL11
33fmlp449.0CCL11, CCL2, CXCL12, TNF
34simvastatin44 50 60 29 25 1213.9CCL2, TNF, CCR5, IL10
35tgf beta1448.8IL10, CCL2, TNF, HDAC9
36endotoxin448.8IL10, TLR3, TNF, CCL2, CCL11
37histamine44 29 2510.7CCR5, IL10, CCL11, CCL2, TNF
38ivig448.6CCR5, IL10, TNF
39actinomycin d448.6TNF, CCL2, CCR5, CXCL12, CCL11
40groalpha448.4CCL11, CCR5, IL10, CCL2, CXCL12, TNF
41tarc448.4CXCL12, TNF, CCL2, CCR5, CCL11, IL10
42ccl344 299.4CXCL12, TNF, CCL2, IL10, CCL11, CCR5
43n acetylcysteine448.3CCL11, CCL2, TNF, HDAC9
44sb 20358044 609.2CCL2, CCL11, CXCL12, IL10, TNF, HDAC9
45vegf448.1CXCL12, CCL2, CCL11, TNF, HDAC9, IL10
46nitric oxide44 25 1210.1TLR3, IL10, CCL11, HDAC9, TNF, CCL2
47rantes448.0CCR5, CCL2, CXCL12, TNF, TLR3, IL10
48ly294002447.8CCL11, IL10, CCL2, TNF, TLR3, HDAC9
49pge2447.7HDAC9, TNF, CXCL12, CCL2, CCL11, IL10
50dexamethasone44 50 29 1210.3IL10, HDAC9, TLR3, CCL11, CCR5, TNF

GO Terms for genes affiliated with Hiv-1 Viremia

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Cellular components related to Hiv-1 Viremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5TNF, CXCL12, CCR5
2extracellular regionGO:0055768.4CCL11, CCL2, CXCL12, TNF, HLA-C
3cell surfaceGO:0099868.0HLA-C, TLR3, TNF, CCR5, MICA
4extracellular spaceGO:0056157.8TNF, CXCL12, CCL2, CCL11, MICA, IL10
5integral component of plasma membraneGO:0058877.2SIGLEC7, MICA, CCR5, CCR2, TNF, TLR3

Biological processes related to Hiv-1 Viremia according to GeneCards/GeneDecks:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immune complex clearance by monocytes and macrophagesGO:09026510.2CCL2, CCR2
2regulation of vascular endothelial growth factor productionGO:01057410.2CCL2, CCR2
3cellular homeostasisGO:01972510.2CCR2, CCL2
4positive regulation of T cell activationGO:05087010.2CCR2, CCL2
5response to radiationGO:00931410.1CCL11, CXCL12
6JAK-STAT cascadeGO:00725910.0CCR2, CCL2
7cellular response to interferon-gammaGO:07134610.0TLR3, CCL2
8dendritic cell chemotaxisGO:00240710.0CCR5, CCR2
9positive regulation of endothelial cell proliferationGO:0019389.9CCL11, CCL2, CXCL12
10cellular response to lipopolysaccharideGO:0712229.8IL10, CCR5, CCL2
11receptor biosynthetic processGO:0328009.8IL10, TNF
12blood vessel remodelingGO:0019749.8CCR2, CCR5
13negative regulation of cytokine secretion involved in immune responseGO:0027409.8TNF, IL10
14cytokine-mediated signaling pathwayGO:0192219.8HLA-C, CCR2, CCL2
15positive regulation of monocyte chemotaxisGO:0900269.7CCR5, CCR2, CXCL12
16negative regulation of growth of symbiont in hostGO:0441309.7TNF, IL10
17positive regulation of synaptic transmissionGO:0508069.7TNF, CCL2
18response to heatGO:0094089.7MICA, CCL2, CXCL12
19negative regulation of interleukin-6 productionGO:0327159.7IL10, TNF
20defense response to bacteriumGO:0427429.6TLR3, MICA, IL10
21positive regulation of cytokine secretionGO:0507159.6IL10, TNF
22necroptotic signaling pathwayGO:0975279.6TNF, TLR3
23positive regulation of chemokine biosynthetic processGO:0450809.6TNF, TLR3
24lipopolysaccharide-mediated signaling pathwayGO:0316639.6TNF, CCL2
25positive regulation of chemokine productionGO:0327229.6TLR3, TNF
26cellular calcium ion homeostasisGO:0068749.6CXCL12, CCR2, CCL2, CCL11
27positive regulation of NF-kappaB import into nucleusGO:0423469.6TNF, TLR3
28protein kinase B signalingGO:0434919.5CCL2, TNF
29cellular response to organic cyclic compoundGO:0714079.5CCL2, TNF
30response to activityGO:0148239.5TNF, CCL2, IL10
31response to glucocorticoidGO:0513849.4TNF, CCL2, IL10
32chemokine-mediated signaling pathwayGO:0700989.4CCR5, CCL2, CCR2, CXCL12
33extrinsic apoptotic signaling pathwayGO:0971919.4TLR3, TNF
34response to mechanical stimulusGO:0096129.4TNF, CXCL12, CCL2
35positive regulation of interferon-gamma productionGO:0327299.4CCR2, TNF
36response to virusGO:0096159.4CCL11, CXCL12, TNF
37cell adhesionGO:0071559.3CXCL12, CCL2, CCL11, SIGLEC7
38G-protein coupled receptor signaling pathwayGO:0071869.3CCR5, CCL2, CXCL12
39response to hypoxiaGO:0016669.3CCL2, CXCL12, TNF
40MAPK cascadeGO:0001659.3CCR5, CCL2, TNF
41positive regulation of interleukin-6 productionGO:0327559.2TNF, TLR3
42viral processGO:0160329.2HLA-C, CCR2, CCR5, MICA
43immune responseGO:0069559.2CCL11, CCR5, CCR2, CXCL12, HLA-C
44chemotaxisGO:0069359.1CXCL12, CCR2, CCL2, CCR5, CCL11
45calcium-mediated signalingGO:0197229.1TNF, CCR5
46response to drugGO:0424938.8IL10, CCL2, TNF
47inflammatory responseGO:0069547.4IL10, HDAC9, TLR3, TNF, CCR2, CCL2

Molecular functions related to Hiv-1 Viremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR2 chemokine receptor bindingGO:0317279.8CCL2, CCR2
2C-C chemokine receptor activityGO:0164939.6CCR2, CCR5
3chemokine activityGO:0080099.5CCL11, CCL2, CXCL12
4receptor bindingGO:0051029.5CCL2, CXCL12, HLA-C
5chemokine receptor activityGO:0049509.4CCR5, CCR2

Products for genes affiliated with Hiv-1 Viremia

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Sources for Hiv-1 Viremia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet