MCID: HVD003
MIFTS: 52

Hiv/aids malady

Download this MalaCard

Summaries for Hiv/aids

About this section


Fully expand this MalaCard
MedlinePlus:33 Hiv stands for human immunodeficiency virus. it kills or damages the body's immune system cells. aids stands for acquired immunodeficiency syndrome. it is the most advanced stage of infection with hiv. hiv most often spreads through unprotected sex with an infected person. it may also spread by sharing drug needles or through contact with the blood of an infected person. women can give it to their babies during pregnancy or childbirth. the first signs of hiv infection may be swollen glands and flu-like symptoms. these may come and go a month or two after infection. severe symptoms may not appear until months or years later. a blood test can tell if you have hiv infection. your health care provider can perform the test, or call the national referral hotline at 1-800-cdc-info (24 hours a day, 1-800-232-4636 in english and en espa├▒ol; 1-888-232-6348 - tty). there is no cure, but there are many medicines to fight both hiv infection and the infections and cancers that come with it. people can live with the disease for many years.

MalaCards based summary: Hiv/aids is related to tuberculosis and acquired immunodeficiency syndrome. An important gene associated with Hiv/aids is CCL3L1 (chemokine (C-C motif) ligand 3-like 1), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Rheumatoid arthritis. The compounds tak-779 and ccl2 have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

CDC:3 What's New in HIV e-HAP keeps you informed about the latest releases from CDC on HIV and related topics.

Description from OMIM:46 609423

Aliases & Classifications for Hiv/aids

About this section

Hiv/aids, Aliases & Descriptions:

Name: Hiv/aids 30 46 33 62


Related Diseases for Hiv/aids

About this section

Graphical network of the top 20 diseases related to Hiv/aids:



Diseases related to hiv/aids

Symptoms for Hiv/aids

About this section


Clinical features from OMIM:

609423

Drugs & Therapeutics for Hiv/aids

About this section

Drug clinical trials:

Search ClinicalTrials for Hiv/aids

Search NIH Clinical Center for Hiv/aids

Genetic Tests for Hiv/aids

About this section

Anatomical Context for Hiv/aids

About this section

MalaCards organs/tissues related to Hiv/aids:

32
Testes, Brain, T cells, Skin, Kidney, Eye, Whole blood, Heart, Smooth muscle, Colon, Thyroid, Salivary gland, B cells, Dorsal root ganglion

Animal Models for Hiv/aids or affiliated genes

About this section

MGI Mouse Phenotypes related to Hiv/aids:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.6IL10, CCR5, CCL2, CCR2, TLR3
2MP:00053709.5IL10, CXCL12, FTH1, CCR2, CCL2, CCR5
3MP:00053979.1TLR3, CXCL12, FTH1, CCR2, CCL2, CCR5
4MP:00053879.0TLR3, CXCL12, FTH1, CCR2, CCL2, CCR5
5MP:00053858.9TLR3, CXCL12, FTH1, CCR2, CCL2, CCR5

Publications for Hiv/aids

About this section

Articles related to Hiv/aids:

(show top 50)    (show all 652)
idTitleAuthorsYear
1
Behavioral Attitudes towards the Use of Male Condoms as a Means of Preventing the HIV/AIDS Spread. (25357555)
2014
2
Trends of Advocacy Journalism; a Case of the HIV/AIDS Story in the Ugandan Press. (25357726)
2014
3
Substance Abuse, Violence, and HIV/AIDS (SAVA) Syndemic Effects on Viral Suppression Among HIV Positive Women of Color. (25397666)
2014
4
Malignancies in HIV/AIDS: from epidemiology to therapeutic challenges. (24401642)
2014
5
Development and future directions for the Joint United Nations Programme on HIV/AIDS estimates. (25406746)
2014
6
Prevalence of oral candidiasis in HIV/AIDS children in highly active antiretroviral therapy-era. A literature analysis. (25156369)
2014
7
Media use and HIV/AIDS knowledge: a knowledge gap perspective. (23644165)
2013
8
Welfare Homes for Patients with HIV/AIDS in Andalusia. (24162615)
2013
9
Oil, migration, and the political economy of HIV/AIDS prevention in Nigeria's Niger Delta. (24397234)
2013
10
Home-based caregiving for people living with HIV/AIDS in South Africa. (23728037)
2013
11
Oral health status of people living with HIV/AIDS attending a specialized service in Brazil. (24266613)
2013
12
The struggle for recognition by people living with HIV/AIDS in Sudan. (23515299)
2013
13
HIV/AIDS-related attitudes and oral impacts on daily performances: a cross-sectional study of Sudanese adult dental patients. (23971974)
2013
14
Providing HIV pre-exposure prophylaxis: lessons learned from the Ryan White HIV/AIDS Program. (23253757)
2013
15
Cutaneous candidiasis caused by Candida glabrata in a HIV/AIDS patient. (23970580)
2013
16
Patient preferences for HIV/AIDS therapy - a discrete choice experiment. (23663390)
2013
17
First Evidence of Genetic Intraspecific Variability and Occurrence of Entamoeba gingivalis in HIV(+)/AIDS. (24376598)
2013
18
Costs of providing food assistance to HIV/AIDS patients in Sofala province, Mozambique: a retrospective analysis. (24103560)
2013
19
Knowledge and Attitude of Basic Health Workers (BHWs) toward HIV/AIDS. (24362608)
2013
20
Assessment of HIV/AIDS knowledge, attitudes and behaviours among students in higher education in Tanzania. (24088049)
2013
21
Potential gains in life expectancy from reducing heart disease, cancer, Alzheimer's disease, kidney disease or HIV/AIDS as major causes of death in the USA. (23507421)
2013
22
Assessing the effects of drug misuse on HIV/AIDS prevalence. (23225069)
2013
23
Gender Differences in Health Related Quality of Life of People Living with HIV/AIDS in the Era of Highly Active Antiretroviral Therapy. (23641370)
2013
24
Impact of pharmacy technician-centered medication reconciliation on optimization of antiretroviral therapy and opportunistic infection prophylaxis in hospitalized patients with HIV/AIDS. (23340912)
2013
25
Trichomonas vaginalis and associated factors among women living with HIV/AIDS in Amazonas, Brazil. (23916452)
2013
26
Assessing the challenges of multi-scope clinical research sites: an example from NIH HIV/AIDS clinical trials networks. (24219425)
2013
27
Optimal diagnostic measures and thresholds for hypogonadism in men with HIV/AIDS: comparison between 2 transdermal testosterone replacement therapy gels. (23816769)
2013
28
Post-Kala-Azar Dermal Leishmaniasis: A Paradigm of Paradoxical Immune Reconstitution Syndrome in Non-HIV/AIDS Patients. (23634148)
2013
29
Factors affecting the HIV/AIDS epidemic: an ecological analysis of global data. (24235928)
2013
30
An ethnographic study of HIV/AIDS among Ayoreo sex workers: cultural factors and risk perception. (24028831)
2013
31
Trends in adolescent sexual behavior, impact of information, and attitudes about HIV/AIDS in Portugal. (24128038)
2013
32
Using a Mandatory Reporting Database to Recruit Persons Living With HIV/AIDS to Study Access to Care in Mississippi. (23945607)
2013
33
Culturally relevant HIV/AIDS education, prevention, screening and treatment for Canadian Inuit. (23618216)
2013
34
Health-related quality of life and physical functioning in people living with HIV/AIDS: a case-control design. (23802924)
2013
35
Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice. (24351796)
2013
36
Developing an adherence support intervention for patients on antiretroviral therapy in the context of the recent IDU-driven HIV/AIDS epidemic in Estonia. (23391132)
2013
37
Effect of HIV infection on pregnancy-related mortality in sub-Saharan Africa: secondary analyses of pooled community-based data from the network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA). (23683643)
2013
38
Substance Abuse Treatment, HIV/AIDS, and the Continuum of Response for People Who Inject Drugs. (23243517)
2012
39
Brain computed tomography of patients with HIV/AIDS before the advent of subsidized treatment program in Nigeria. (23661884)
2012
40
Successful testing and treating of HIV/AIDS in Indonesia depends on the addiction treatment modality. (23293529)
2012
41
Prevalence of bacterial vaginosis and its risk factors in HIV/AIDS patients with abnormal vaginal discharge. (21771443)
2011
42
A complicated case of cholecystitis, listeriosis and HIV/AIDS. (22715268)
2011
43
HIV-associated nemaline rod myopathy: role of intravenous immunoglobulin therapy in two persons with HIV/AIDS. (18330038)
2008
44
Images in HIV/AIDS. HIV-associated lymphogranuloma venereum proctitis. (17396331)
2007
45
Images in HIV/AIDS. Invasive aspergillosis presenting as a neck mass in a person with HIV/AIDS. (17672013)
2007
46
Interaction between allelic variation in IL12B and CCR5 affects the development of AIDS: IL12B/CCR5 interaction and HIV/AIDS. (17148969)
2007
47
Activation and coreceptor expression of T lymphocytes induced by highly active antiretroviral therapy in Chinese HIV/AIDS patients. (17199940)
2006
48
Activation and coreceptor expression of T lymphocytes in HIV/AIDS patients of China. (15742159)
2005
49
The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. (12676886)
2003
50
Influence of HIV/AIDS infection on some biochemical indicators of the nutritional status]. (12152477)
2002

Variations for Hiv/aids

About this section

Clinvar genetic disease variations for Hiv/aids:

6 (show all 11)
id Gene Name Type Significance SNP ID Assembly Location
1CCL2CCL2, -2136A-Tsingle nucleotide variantPathogenic
2CCL2CCL2, 767C-Gsingle nucleotide variantPathogenic
3IL10IL10, -592C-Asingle nucleotide variantPathogenic
4TLR3NM_003265.2(TLR3): c.1234C> T (p.Leu412Phe)single nucleotide variantPathogenicrs3775291GRCh37Chr 4, 187004074: 187004074
5NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs)deletionPathogenicrs333GRCh37Chr 3, 46414947: 46414978
6NM_000579.3(CCR5): c.303T> A (p.Cys101Ter)single nucleotide variantPathogenicrs1800560GRCh37Chr 3, 46414696: 46414696
7NM_000579.3(CCR5): c.180G> T (p.Arg60Ser)single nucleotide variantPathogenicrs1800940GRCh37Chr 3, 46414573: 46414573
8CCR5CCR5, 2459A-Gsingle nucleotide variantPathogenic
9CCR2NM_001123041.2(CCR2): c.190G> A (p.Val64Ile)single nucleotide variantPathogenicrs1799864GRCh37Chr 3, 46399208: 46399208
10CCL11CCL11, -1385G-Asingle nucleotide variantPathogenic
11CXCL12NM_000609.6(CXCL12): c.266+535G> Asingle nucleotide variantPathogenicrs387906400GRCh37Chr 10, 44873550: 44873550

Expression for genes affiliated with Hiv/aids

About this section
Expression patterns in normal tissues for genes affiliated with Hiv/aids

Search GEO for disease gene expression data for Hiv/aids.

Pathways for genes affiliated with Hiv/aids

About this section

Pathways related to Hiv/aids according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CCL11, CCL2
210.0CXCL12, CCL2, CCL3L1
310.0IL10, CCR2, CXCL12
4
Show member pathways
9.5CXCL12, CCR2, CCL2, CCR5, CCL3L1, CCL11
5
Show member pathways
9.5CXCL12, CCR2, CCL2, CCR5, CCL3L1, CCL11
6
Show member pathways
9.5CXCL12, CCR2, CCL2, CCR5, CCL3L1, CCL11
7
Show member pathways
9.5CXCL12, CCR2, CCL2, CCR5, CCL3L1, CCL11
8
Show member pathways
9.3CXCL12, CCR2, CCL2, CCR5, CCL3L1, CCL11
9
Show member pathways
9.3CXCL12, CCR2, CCL2, CCR5, CCL3L1, CCL11
10
Show member pathways
9.2TLR3, CXCL12, CCR2, CCL2, CCR5, CCL3L1
118.3IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA10
12
Show member pathways
8.3IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA10
13
Show member pathways
8.3IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA10
14
Show member pathways
Immune response CD16 signaling in NK cells60
8.0IFNA13, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7
158.0IFNA13, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7
168.0IFNA17, IFNA16, IFNA10, IFNA13, IFNA21, IFNA4
178.0IFNA13, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7
18
Show member pathways
8.0IFNA5, IFNA6, IFNA7, IFNA10, IFNA17, IFNA16
198.0IFNA13, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7
20
Show member pathways
8.0IFNA10, IFNA17, IFNA16, IFNA7, IFNA6, IFNA5
21
Show member pathways
Type III interferon signaling37
7.9IFNA13, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7
227.9IL10, IFNA16, IFNA13, IFNA21, IFNA4, IFNA5
237.9IFNA13, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7
247.9IFNA16, IFNA17, IFNA10, TLR3, IFNA13, IFNA21
25
Show member pathways
7.9IFNA13, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7
26
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
7.9IFNA4, IFNA5, IFNA6, IFNA7, IFNA10, IFNA17
27
Show member pathways
7.7TLR3, CCL2, IFNA13, IFNA21, IFNA4, IFNA5
28
Show member pathways
7.6IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA10
29
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
7.4CCL2, IL10, IFNA16, IFNA17, CCL3L1, IFNA13
30
Show member pathways
7.2CXCL12, CCL2, CCL3L1, CCL11, IFNA13, IFNA21
31
Show member pathways
6.9IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA10

Compounds for genes affiliated with Hiv/aids

About this section

Compounds related to Hiv/aids according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1tak-7792810.5CCR2, CCR5
2ccl22810.5CCR2, CCR5
3ccl162810.5CCR5, CCR2
4ccl82810.5CCR2, CCR5
5ccl112810.5CCR2, CCR5
6bicyclam4410.5CXCL12, CCR5
7ccl132810.5CCR5, CCR2
8vmip-ii2810.5CCR2, CCR5
9ccl72810.5CCR5, CCR2
10tc 140126110.4CCR2, CCR5
11sb 22500261 2811.4CCR2, CCR5
12sdf 14410.4CCL2, CXCL12, CCR5
13shikonin4410.4CCR5, CCL2, CXCL12
14larc4410.4CXCL12, CCL2, CCR5
15sb 2656106110.4CCR2, CCR5
16mip 1alpha4410.4CCR5, CCL2, IL10
17lipoteichoic acid4410.4CCL2, TLR3, IL10
18rs 5043936110.4CCR5, CCR2
19pertussis4410.4CXCL12, CCL2, CCL11
20galactosylceramide4410.3CCR5, CXCL12
21il 104410.3IL10, CCR5, CCL2
22grobeta4410.3CXCL12, CCL2
23ifn-alpha4410.3IL10, TLR3, CXCL12
24peptidoglycan44 2811.3IL10, CCL11, TLR3
2515-deoxy-delta-12,14-prostaglandin j24410.3CCL11, IL10, CCL2
26quinine44 28 2 50 1114.3IL10, CCR5, CXCL12
27roxithromycin44 28 1112.3CCL11, CYP2B6
28mdms4410.2IL10, CCR5, CCL2, CXCL12
29maraviroc44 61 50 28 1114.2CCR5, CCR2
30endotoxin4410.2IL10, CCL11, CCL2, TLR3
31cyclophosphamide44 50 1112.2CCL2, CXCL12, CYP2B6, IL10
32mcp 14410.2IL10, CCL2
33simvastatin44 50 61 28 24 1115.1IL10, CCR5, CYP2B6, CCL2
34sb 20358044 6111.1IL10, CXCL12, CCL2, CCL11
35leukotriene b444 61 2412.1CCL11, CCL2, CYP2B6
36ccl444 2811.1CCR5, CCL2, CCL3L1, CCL11, CXCL12
37groalpha4410.1CCR5, CCL11, IL10, CXCL12, CCL2
38histamine44 28 2412.1CCR5, IL10, CCL2, CCL11
39tarc4410.1CCL2, CCL11, IL10, CCR5, CXCL12
40ly2940024410.1CCL11, CXCL12, TLR3, IL10, CCL2
41toxin-14410.0CCL2, IL10
42vitamin d4410.0CYP2B6, CCL2, CCR5, IL10
43pge24410.0CCL2, CCL11, CXCL12, CCR5, IL10
44zidovudine44 50 1112.0CYP2B6, CCL2, CCR5, CXCL12, IL10
45ccl344 2810.9CXCL12, CCL2, CCL3L1, CCR5, CCL11, IL10
46atorvastatin44 50 28 24 1113.9CCL2, CYP2B6, IL10
47actinomycin d449.9CXCL12, CCL2, CCR5, CCL11
48rantes449.7CCL2, CXCL12, CCR5, CCL3L1, CCL11, IL10
49dexamethasone44 50 28 1112.7IL10, TLR3, CXCL12, CYP2B6, CCL11, CCL2
50nitric oxide44 24 1111.3IL10, CCL11, CYP2B6, TLR3, CCL2

GO Terms for genes affiliated with Hiv/aids

About this section

Cellular components related to Hiv/aids according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.6CCL2, CCL11, IFNA13, IFNA21, IFNA4, IFNA5
2extracellular spaceGO:0056157.1IL10, CXCL12, CCL2, CCL11, IFNA13, IFNA21

Biological processes related to Hiv/aids according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immune complex clearance by monocytes and macrophagesGO:09026510.4CCL2, CCR2
2regulation of vascular endothelial growth factor productionGO:01057410.4CCR2, CCL2
3cellular homeostasisGO:01972510.3CCL2, CCR2
4positive regulation of monocyte chemotaxisGO:09002610.3CXCL12, CCR2, CCR5
5dendritic cell chemotaxisGO:00240710.2CCR5, CCR2
6positive regulation of T cell activationGO:05087010.2CCL2, CCR2
7positive regulation of endothelial cell proliferationGO:00193810.2CCL11, CCL2, CXCL12
8response to activityGO:01482310.1IL10, CCL2
9cellular response to interferon-gammaGO:07134610.1TLR3, CCL2
10chemokine-mediated signaling pathwayGO:07009810.1CXCL12, CCR2, CCL2, CCR5
11cellular response to lipopolysaccharideGO:07122210.1CCL2, CCR5, IL10
12cellular calcium ion homeostasisGO:00687410.1CCL11, CCL2, CCR2, CXCL12
13response to radiationGO:00931410.0CCL11, CXCL12
14chemotaxisGO:0069359.9CXCL12, CCR2, CCL2, CCR5, CCL11
15JAK-STAT cascadeGO:0072599.9CCL2, CCR2
16immune responseGO:0069559.8CXCL12, FTH1, CCR2, CCR5, CCL11
17inflammatory responseGO:0069549.7IL10, CCL11, CCR5, CCL2, CCR2, TLR3
18response to virusGO:0096159.7IFNA17, IFNA7, IFNA4, CCL11, CXCL12
19adaptive immune responseGO:0022508.5IFNA17, IFNA10, IFNA7, IFNA6, IFNA5, IFNA4
20natural killer cell activation involved in immune responseGO:0023238.4IFNA16, IFNA17, IFNA10, IFNA7, IFNA6, IFNA5
21positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:0331418.4IFNA16, IFNA17, IFNA10, IFNA7, IFNA6, IFNA5
22T cell activation involved in immune responseGO:0022868.4IFNA13, IFNA21, IFNA4, IFNA16, IFNA17, IFNA10
23type I interferon signaling pathwayGO:0603378.4IFNA6, IFNA5, IFNA4, IFNA21, IFNA13, IFNA7
24regulation of type I interferon-mediated signaling pathwayGO:0603388.4IFNA16, IFNA17, IFNA10, IFNA7, IFNA6, IFNA5
25regulation of MHC class I biosynthetic processGO:0453438.4IFNA16, IFNA17, IFNA10, IFNA7, IFNA6, IFNA5
26blood coagulationGO:0075968.4IFNA13, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7
27humoral immune responseGO:0069598.3IFNA4, IFNA21, IFNA13, CCL2, IFNA5, IFNA6
28B cell differentiationGO:0301838.2IL10, IFNA16, IFNA17, IFNA10, IFNA7, IFNA6
29B cell proliferationGO:0421008.2IL10, IFNA16, IFNA17, IFNA10, IFNA7, IFNA6
30response to exogenous dsRNAGO:0433308.2IFNA21, IFNA13, TLR3, IFNA4, IFNA5, IFNA6
31defense response to virusGO:0516078.2IFNA16, IFNA17, IFNA10, IFNA7, IFNA6, IFNA5
32cytokine-mediated signaling pathwayGO:0192218.1IFNA16, IFNA17, IFNA10, IFNA7, IFNA6, IFNA5
33innate immune responseGO:0450878.1TLR3, CCR2, IFNA13, IFNA21, IFNA4, IFNA5

Molecular functions related to Hiv/aids according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1CCR2 chemokine receptor bindingGO:03172710.2CCR2, CCL2
2chemokine receptor activityGO:00495010.1CCR5, CCR2
3chemokine activityGO:00800910.0CCL11, CCL2, CXCL12
4C-C chemokine receptor activityGO:0164939.8CCR5, CCR2
5cytokine receptor bindingGO:0051269.8IFNA21, IFNA5
6type I interferon receptor bindingGO:0051328.2IFNA17, IFNA10, IFNA7, IFNA6, IFNA5, IFNA4
7cytokine activityGO:0051258.0IL10, IFNA13, IFNA16, IFNA17, IFNA10, IFNA7

Products for genes affiliated with Hiv/aids

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Hiv/aids

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet