MCID: HDG012
MIFTS: 86

Hodgkin Lymphoma malady

Genetic diseases, Rare diseases, Cancer diseases, Immune diseases categories

Summaries for Hodgkin Lymphoma

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MedlinePlus:34 Hodgkin disease is a type of lymphoma. lymphoma is a cancer of a part of the immune system called the lymph system. the first sign of hodgkin disease is often an enlarged lymph node. the disease can spread to nearby lymph nodes. later it may spread to the lungs, liver, or bone marrow. the exact cause is unknown. hodgkin disease is rare. symptoms include painless swelling of the lymph nodes in the neck, armpits, or groin fever and chills night sweats weight loss loss of appetite itchy skin to diagnose hodgkin disease, doctors use a physical exam and history, blood tests, and a biopsy. treatment depends on how far the disease has spread. it often includes radiation therapy or chemotherapy. the earlier the disease is diagnosed, the more effective the treatment. in most cases, hodgkin disease can be cured. nih: national cancer institute

MalaCards based summary: Hodgkin Lymphoma, also known as hodgkin disease, is related to leukemia and b-cell lymphomas, and has symptoms including lymphoma, lymphadenopathy and abnormality of immune system physiology. An important gene associated with Hodgkin Lymphoma is KLHDC8B (kelch domain containing 8B), and among its related pathways are Death Receptor Signalling and DNA damage ATM ATR regulation of G1 S checkpoint. The drugs carmustine and chlorambucil and the compounds 7,12-dimethylbenz(a)anthracene and bpde have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Disease Ontology:10 A lymphoma that is marked by the presence of a type of cell called the reed-sternberg cell.

Wikipedia:65 Hodgkin lymphoma, also known as Hodgkin\'s lymphoma or Hodgkin\'s disease, (Latin. Lymphogranulomatosis... more...

Description from OMIM:47 246000

Aliases & Classifications for Hodgkin Lymphoma

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Hodgkin Lymphoma, Aliases & Descriptions:

Name: Hodgkin Lymphoma 47 10 11 43 32
Hodgkin Disease 10 43 45 34
Hodgkin's Lymphoma 32 10 43
Hodgkins Lymphoma 10 43 12
Lymphoma, Hodgkin's 43 24
Leg, Absence Deformity of, with Congenital Cataract 47
 
Stage Ii Subdiaphragmatic Hodgkin Lymphoma 10
Stage I Subdiaphragmatic Hodgkin Lymphoma 10
Hodgkin's Sarcoma 10
Hodgkins Disease 43
Hl 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Immune diseases


Related Diseases for Hodgkin Lymphoma

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Diseases related to Hodgkin Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 391)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.2CFLAR, NBN, PTPRC, TIA1, PAX5, REL
2b-cell lymphomas31.2CFLAR, NBN, TNFRSF8, PTPRC, TIA1, PAX5
3chronic lymphocytic leukemia31.1TNFSF8, TNFRSF8, PAX5, BCL6
4anaplastic large cell lymphoma31.0TNFSF8, TNFRSF8, PTPRC, PAX5, BCL6
5mantle cell lymphoma31.0MDM2, BCL6
6lymphoma, non-hodgkin30.9BRAF, CASP10
7myeloma30.8CFLAR, TNFRSF8, PTPRC, PAX5, BCL6
8sarcoma30.7MDM2, BRAF, PTPRC, CFLAR
9lymphomatoid papulosis30.7TNFRSF8, TIA1
10peripheral t-cell lymphoma30.6TNFRSF8, PTPRC, TIA1, PAX5, BCL6
11ataxia-telangiectasia30.6NBN, HPRT1, MDM2
12follicular lymphoma30.5PTPRC, PAX5, REL, BCL6
13burkitt lymphoma30.5CFLAR, TNFRSF8, PAX5, BCL6, MDM2
14lymphoblastic lymphoma30.4BCL6, PAX5, PTPRC
15breast cancer30.4NBN, TNFAIP3, PTPRC, HPRT1, CASP10, MDM2
16central nervous system lymphoma30.3BCL6
17colorectal cancer30.2CFLAR, BRAF, HPRT1, CASP10, CARD16, MDM2
18melanoma30.2CFLAR, NBN, PTPRC, TIA1, BRAF, HPRT1
19angioimmunoblastic t-cell lymphoma30.1BCL6
20autoimmune lymphoproliferative syndrome30.1PTPRC, CASP10
21stomach cancer30.1CFLAR, NBN, BRAF, CASP10
22lung cancer30.0MDM2, BRAF, NBN, CFLAR
23nodular lymphocyte predominant hodgkin lymphoma11.0
24hepatitis10.7
25diffuse large b-cell lymphoma10.6
26mediastinitis10.6
27hepatitis c10.6
28multiple myeloma10.5
29hematopoietic stem cell transplantation10.5
30hemolytic anemia10.5
31autoimmune hemolytic anemia10.5
32mixed cellularity classical hodgkin lymphoma10.5
33lymphocyte-rich classical hodgkin lymphoma10.5
34hepatitis b10.5
35progressive multifocal leukoencephalopathy10.5
36hodgkin's lymphoma, lymphocytic depletion10.5
37t-cell/histiocyte rich large b cell lymphoma10.5
38neutropenia10.4
39composite lymphoma10.4
40lymphoblastic leukemia10.4
41mycosis fungoides10.4
42cryoglobulinemia10.4
43gray zone lymphoma10.4
44pneumonia10.4
45endotheliitis10.4
46primary mediastinal large b-cell lymphoma10.4
47hepatitis c virus10.3
48common variable immunodeficiency10.3
49hemophagocytic lymphohistiocytosis10.3
50malt lymphoma10.3

Graphical network of the top 20 diseases related to Hodgkin Lymphoma:



Diseases related to hodgkin lymphoma

Symptoms for Hodgkin Lymphoma

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Symptoms by clinical synopsis from OMIM:

246000

Clinical features from OMIM:

246000

HPO human phenotypes related to Hodgkin Lymphoma:

(show all 21)
id Description Frequency HPO Source Accession
1 lymphoma hallmark (90%) HP:0002665
2 lymphadenopathy hallmark (90%) HP:0002716
3 abnormality of immune system physiology hallmark (90%) HP:0010978
4 hyperhidrosis typical (50%) HP:0000975
5 pruritus typical (50%) HP:0000989
6 weight loss typical (50%) HP:0001824
7 anorexia typical (50%) HP:0002039
8 abnormality of temperature regulation typical (50%) HP:0004370
9 chest pain typical (50%) HP:0100749
10 splenomegaly occasional (7.5%) HP:0001744
11 migraine occasional (7.5%) HP:0002076
12 respiratory insufficiency occasional (7.5%) HP:0002093
13 hemoptysis occasional (7.5%) HP:0002105
14 hepatomegaly occasional (7.5%) HP:0002240
15 incoordination occasional (7.5%) HP:0002311
16 bone pain occasional (7.5%) HP:0002653
17 bone marrow hypocellularity occasional (7.5%) HP:0005528
18 peripheral neuropathy occasional (7.5%) HP:0009830
19 autosomal recessive inheritance HP:0000007
20 congenital cataract HP:0000519
21 scoliosis HP:0002650

Drugs & Therapeutics for Hodgkin Lymphoma

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Genetic Tests for Hodgkin Lymphoma

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Genetic tests related to Hodgkin Lymphoma:

id Genetic test Affiliating Genes
1 Hodgkin Lymphoma24

Anatomical Context for Hodgkin Lymphoma

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MalaCards organs/tissues related to Hodgkin Lymphoma:

33
B cells, T cells, Bone, Bone marrow, Liver, Lymph node, Skin, Lung, Testes, Breast, Myeloid, Monocytes, Endothelial, Spinal cord, Heart, Kidney, Thyroid, Prostate, Brain, Nk cells, Pituitary, Spleen, Small intestine, Testis, Cervix, B lymphoblasts, Tongue, Neutrophil

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Hodgkin Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Hodgkin Lymphoma or affiliated genes

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Publications for Hodgkin Lymphoma

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Articles related to Hodgkin Lymphoma:

(show top 50)    (show all 1453)
idTitleAuthorsYear
1
Dietary patterns and the risk of non-Hodgkin lymphoma. (23659580)
2013
2
Primary non-Hodgkin lymphoma of the bladder. (24369199)
2013
3
Atrazine and nitrate in public drinking water supplies and non-hodgkin lymphoma in nebraska, USA. (23515852)
2013
4
Biodistribution and dosimetry of (177)Lu-tetulomab, a new radioimmunoconjugate for treatment of non-Hodgkin lymphoma. (23256748)
2013
5
The prognostic impact of variant histology in nodular lymphocyte-predominant Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG). (24100447)
2013
6
Unusual hairy cell projections in hepatosplenic T-cell non-Hodgkin lymphoma. (23593648)
2013
7
External validation of a risk model of febrile neutropenia occurrence in patients with non-Hodgkin lymphoma. (23452152)
2013
8
Angiokeratoma corporis diffusum in a patient with Hodgkin lymphoma: a new paraneoplastic skin manifestation? (23278357)
2013
9
Non-Hodgkin lymphoma as an uncommon cause of acute heart failure. (23503834)
2013
10
Treatment of nodular lymphocyte-predominant Hodgkin lymphoma-"do no harm". (24472810)
2013
11
Front-line immunochemotherapy for aggressive non-Hodgkin lymphoma using dose-dense rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone plus granulocyte-macrophage colony stimulating factor and pegfilgrastim as support. (22448918)
2012
12
Analysis of very elderly (a8Y80 years) non-hodgkin lymphoma: impact of functional status and co-morbidities on outcome. (22084970)
2012
13
The association of hepatitis B virus infection with B-cell non-Hodgkin lymphoma - a review. (22432084)
2012
14
Treatment option of bendamustine in combination with rituximab in elderly and frail patients with aggressive B-non-Hodgkin lymphoma: rational, efficacy, and tolerance. (22752146)
2012
15
Assessment of immunovirological features in HIV related non-Hodgkin lymphoma patients and their impact on outcome. (22244256)
2012
16
The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma. (22781692)
2012
17
Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability. (21488163)
2011
18
Results of the Japan Association of Childhood Leukemia Study (JACLS) NHL-98 protocol for the treatment of B-cell non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia in childhood. (21261497)
2011
19
Expression of serine 194-phosphorylated Fas-associated death domain protein correlates with proliferation in B-cell non-Hodgkin lymphomas. (21315423)
2011
20
Non-hodgkin lymphoma in a child with schimke immuno-osseous dysplasia. (23359635)
2011
21
Soluble IL-2RI+ facilitates IL-2-mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma. (21719603)
2011
22
Sexual well-being among survivors of non-Hodgkin lymphoma. (21875831)
2011
23
Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study. (20299965)
2010
24
KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma. (20519630)
2010
25
Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma. (19101572)
2009
26
Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. (19066394)
2009
27
Functional signatures identified in B-cell non-Hodgkin lymphoma profiles. (19863341)
2009
28
A 19-year follow-up of a patient with type 3 ectrodactyly-ectodermal dysplasia-clefting syndrome who developed non-Hodgkin lymphoma. (19716498)
2009
29
Interleukine-2 therapy does not increase the risk of Hodgkin or non-Hodgkin lymphoma in HIV-infected patients: results from FHDH ANRS CO4. (19131886)
2009
30
Non-Hodgkin lymphoma (NHL) in children with Nijmegen Breakage syndrome (NBS). (18937313)
2009
31
Fatal chylous ascites, pericarditis and extensive venous thrombosis, due to an aggressive T cell non-Hodgkin lymphoma. (18679682)
2009
32
Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines. (18541724)
2008
33
The NF-kappaB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs. (18949621)
2008
34
Non-Hodgkin lymphoma related to hereditary nonpolyposis colorectal cancer in a patient with a novel heterozygous complex deletion in the MSH2 gene. (18181177)
2008
35
Paraneoplastic lumbosacral axonal polyradiculopathy preceding the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma: a case report. (18720211)
2008
36
'Precursors' of classical Hodgkin lymphoma in samples of angioimmunoblastic T-cell lymphoma. (18324974)
2008
37
HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma. (17630352)
2007
38
Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6. (17652621)
2007
39
Genetic polymorphisms in the proximal IL-10 promoter and susceptibility to non-Hodgkin lymphoma. (17990180)
2007
40
High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma. (17375124)
2007
41
Outcome of children with nodular lymphocyte predominant Hodgkin lymphoma - a Children's Cancer and Leukaemia Group report. (17760808)
2007
42
Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma. (16740140)
2006
43
Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut. (16738949)
2006
44
Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. (16857995)
2006
45
A putative exonic splicing polymorphism in the BCL6 gene and the risk of non-Hodgkin lymphoma. (16264183)
2005
46
Intensive sequential chemotherapy with hematopoietic growth factor support for non-Hodgkin lymphoma in patients infected with the human immunodeficiency virus. (14770420)
2004
47
Expression profile and prognostic significance of CD24, p53 and p21 in lymphomas. A tissue microarray study of over 600 non-Hodgkin lymphomas]. (15455300)
2004
48
Antibody-targeted therapy: a paradigm of innovative treatment strategies in indolent and aggressive B-cell non-Hodgkin lymphoma. (15548997)
2004
49
The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. (14608905)
2003
50
Therapy-related acute leukemia associated with involvement of 11q23 after high grade non-Hodgkin lymphoma. (9573684)
1998

Variations for Hodgkin Lymphoma

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Clinvar genetic disease variations for Hodgkin Lymphoma:

7
id Gene Variation Type Significance SNP ID Assembly Location
1KLHDC8BNM_173546.2(KLHDC8B): c.-158C> Tsingle nucleotide variantPathogenicrs387906223GRCh37Chr 3, 49209095: 49209095

Cosmic variations for Hodgkin Lymphoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
144571TP53haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,Hodgkin lymphoma1

Expression for genes affiliated with Hodgkin Lymphoma

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Search GEO for disease gene expression data for Hodgkin Lymphoma.

Pathways for genes affiliated with Hodgkin Lymphoma

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Pathways related to Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0CFLAR, CASP10
29.9NBN, REL, MDM2
3
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.8MDM2, CASP10, CFLAR
4
Show member pathways
9.8REL, BRAF, TNFAIP3
59.8CFLAR, TNFAIP3, CASP10
6
Show member pathways
9.8CFLAR, TNFAIP3, CASP10
79.8CASP10, TNFAIP3, CFLAR
8
Show member pathways
9.8TNFSF8, TNFRSF8, CASP10
99.8MDM2, CASP10, BCL6
10
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.8MDM2, BCL6, BRAF
11
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.7PDCD1, REL, PTPRC
12
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.7TNFSF8, TNFRSF8, REL
139.7BCL6, PAX5, PTPRC
14
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
9.6MDM2, CASP10, REL, CFLAR
159.5MDM2, BCL6, REL, PAX5
16
Show member pathways
9.5TNFSF8, TNFRSF8, TNFAIP3, CASP10
179.5BCL6, REL, BRAF, PTPRC
18
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.5PTPRC, BRAF, REL, BCL6
19
Show member pathways
9.3CFLAR, TNFSF8, TNFRSF8, BRAF, CASP10
20
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.3CASP10, REL, PTPRC, TNFAIP3, CFLAR
21
Show member pathways
Alternative NF-kappaB pathway38
9.2CFLAR, TNFRSF8, TNFAIP3, REL, CASP10
22
Show member pathways
9.1CFLAR, TNFSF8, TNFRSF8, BRAF, CASP10, MDM2

Compounds for genes affiliated with Hodgkin Lymphoma

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Compounds related to Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
17,12-dimethylbenz(a)anthracene4510.3MDM2, REL
2bpde4510.3MDM2, HPRT1
3methylmethanesulfonate4510.3MDM2, HPRT1, NBN
4mitomycin c4510.2MDM2, HPRT1, NBN
5geldanamycin45 51 61 1313.2CFLAR, BRAF, MDM2
6p0024510.1CFLAR, BRAF, MDM2
7o6-methylguanine4510.1HPRT1, BRAF
8adenine45 26 1312.1TIA1, BRAF, HPRT1
9adriamycin4510.1MDM2, HPRT1, CFLAR
10rituximab45 51 1312.0BCL6, PAX5, CFLAR
11paclitaxel45 51 1312.0CFLAR, BRAF, CASP10, MDM2
12rapamycin4510.0MDM2, BRAF, NBN, CFLAR
13dutp4510.0CFLAR, CARD16, MDM2
14vincristine45 51 1312.0MDM2, BCL6, CFLAR
15imatinib45 51 1311.9MDM2, BCL6, BRAF, CFLAR
16cisplatin45 51 61 1312.9CFLAR, BRAF, HPRT1, CASP10, MDM2
17irinotecan45 51 1311.8CFLAR, BRAF, CARD16, MDM2
18cyclophosphamide45 51 1311.8HPRT1, BCL6, MDM2
19[alcl]459.8TNFRSF8, PTPRC, TIA1, PAX5
20camptothecin45 61 1311.8CFLAR, NBN, CARD16, MDM2
215-aza-2deoxycytidine459.8CFLAR, HPRT1, MDM2
22doxorubicin45 51 1311.8CFLAR, NBN, BCL6, MDM2
23oligonucleotide459.8CFLAR, BRAF, PAX5, REL, MDM2
24testosterone45 61 26 1312.7MDM2, HPRT1, PAX5, PTPRC, CFLAR
25phosphatidylinositol459.7CFLAR, NBN, PTPRC, BRAF, MDM2
26arsenite45 2610.7MDM2, TIA1, CFLAR
27h2o2459.6CFLAR, TNFAIP3, PTPRC, HPRT1, MDM2
28etoposide45 51 61 1312.6CFLAR, NBN, HPRT1, CARD16, MDM2
29thymidine45 2610.6CFLAR, TNFRSF8, HPRT1, MDM2
30valine459.6MDM2, HPRT1, BRAF
31cyclosporin a45 30 6111.6CFLAR, TNFRSF8, PTPRC, REL
32cycloheximide459.5CFLAR, TNFAIP3, PTPRC, BCL6, MDM2
33nitric oxide45 26 1311.4CFLAR, TNFAIP3, REL, CARD16, MDM2
34estrogen459.3PTPRC, BRAF, REL, BCL6, MDM2
35zinc45 2610.3TNFRSF8, TNFAIP3, PAX5, REL, BCL6, MDM2
36cysteine459.1CFLAR, PTPRC, REL, HPRT1, CASP10, CARD16
37paraffin459.1TNFRSF8, PTPRC, TIA1, BRAF, PAX5, BCL6
38threonine458.9CFLAR, NBN, TNFRSF8, PTPRC, TIA1, BRAF
39calcium45 51 26 1311.9CFLAR, TNFRSF8, PTPRC, BRAF, PAX5, REL
40tyrosine458.2CFLAR, TNFRSF8, PTPRC, BRAF, PAX5, REL
41serine457.6MDM2, CFLAR, NBN, TNFRSF8, PTPRC, TIA1

GO Terms for genes affiliated with Hodgkin Lymphoma

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Cellular components related to Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CD95 death-inducing signaling complexGO:00312659.9CASP10, CFLAR
2replication forkGO:00056579.9BCL6, NBN
3ripoptosomeGO:00973429.7CASP10, CFLAR

Biological processes related to Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.8CASP10, REL, CFLAR
2regulation of germinal center formationGO:00026349.8TNFAIP3, BCL6
3negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:019020429.7TNFAIP3, CFLAR
4apoptotic processGO:00069159.1PDCD1, CASP10, TIA1, TNFAIP3, TNFSF8, CFLAR

Molecular functions related to Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1death effector domain bindingGO:003587710.0CASP10, CFLAR
2protein bindingGO:00055157.1MDM2, CFLAR, NBN, TNFAIP3, PTPRC, FCRL4

Products for genes affiliated with Hodgkin Lymphoma

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Sources for Hodgkin Lymphoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet