MCID: HDG012
MIFTS: 79

Hodgkin Lymphoma malady

Genetic diseases, Rare diseases, Cancer diseases, Immune diseases categories

Summaries for Hodgkin Lymphoma

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MedlinePlus:32 Hodgkin disease is a type of lymphoma. lymphoma is a cancer of a part of the immune system called the lymph system. the first sign of hodgkin disease is often an enlarged lymph node. the disease can spread to nearby lymph nodes. later it may spread to the lungs, liver, or bone marrow. the exact cause is unknown. hodgkin disease is rare. symptoms include painless swelling of the lymph nodes in the neck, armpits, or groin fever and chills night sweats weight loss loss of appetite itchy skin to diagnose hodgkin disease, doctors use a physical exam and history, blood tests, and a biopsy. treatment depends on how far the disease has spread. it often includes radiation therapy or chemotherapy. the earlier the disease is diagnosed, the more effective the treatment. in most cases, hodgkin disease can be cured. nih: national cancer institute

MalaCards based summary: Hodgkin Lymphoma, also known as hodgkin disease, is related to lymphoma, non-hodgkin and mantle cell lymphoma, and has symptoms including lymphoma, lymphadenopathy and abnormality of immune system physiology. An important gene associated with Hodgkin Lymphoma is KLHDC8B (kelch domain containing 8B), and among its related pathways are Death Receptor Signalling and DNA damage ATM ATR regulation of G1 S checkpoint. The drugs carmustine and cyclophosphamide and the compounds 7,12-dimethylbenz(a)anthracene and bpde have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lymph node, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Disease Ontology:9 A lymphoma that is marked by the presence of a type of cell called the reed-sternberg cell.

Wikipedia:63 Hodgkin lymphoma, also known as Hodgkin\'s lymphoma or Hodgkin\'s disease, (Latin. Lymphogranulomatosis... more...

Description from OMIM:45 246000

Aliases & Classifications for Hodgkin Lymphoma

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Hodgkin Lymphoma, Aliases & Descriptions:

Name: Hodgkin Lymphoma 45 9 10 41 30
Hodgkin Disease 9 41 43 32 60
Hodgkin's Lymphoma 30 9 41
Hodgkins Lymphoma 9 41 11
Lymphoma, Hodgkin's 41 22
Hodgkin's Disease of Lymph Nodes of Inguinal Region and/or Lower Limb 60
Leg, Absence Deformity of, with Congenital Cataract 45
 
Hodgkin's Disease of Intrapelvic Lymph Nodes 60
Stage Ii Subdiaphragmatic Hodgkin Lymphoma 9
Stage I Subdiaphragmatic Hodgkin Lymphoma 9
Hodgkin's Sarcoma 9
Hodgkins Disease 41
Hl 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Immune diseases


Related Diseases for Hodgkin Lymphoma

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Diseases related to Hodgkin Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 392)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, non-hodgkin31.5BRAF, CASP10
2mantle cell lymphoma31.5MDM2, BCL6
3chronic lymphocytic leukemia31.4TNFSF8, TNFRSF8, PAX5, BCL6
4anaplastic large cell lymphoma31.1TNFSF8, TNFRSF8, PTPRC, PAX5, BCL6
5lymphomatoid papulosis31.1TIA1, TNFRSF8
6ataxia-telangiectasia31.0MDM2, NBN, HPRT1
7central nervous system lymphoma30.9BCL6
8sarcoma30.9BRAF, CFLAR, PTPRC, MDM2
9myeloma30.8TNFRSF8, CFLAR, PAX5, BCL6, PTPRC
10lymphoblastic lymphoma30.8PTPRC, PAX5, BCL6
11angioimmunoblastic t-cell lymphoma30.7BCL6
12follicular lymphoma30.7PTPRC, PAX5, BCL6, REL
13peripheral t-cell lymphoma30.7TNFRSF8, PAX5, PTPRC, TIA1, BCL6
14burkitt lymphoma30.6PAX5, MDM2, CFLAR, TNFRSF8, BCL6
15b-cell lymphomas30.5NBN, CFLAR, TNFRSF8, PTPRC, TIA1, PAX5
16autoimmune lymphoproliferative syndrome30.4PTPRC, CASP10
17stomach cancer30.3NBN, CASP10, BRAF, CFLAR
18leukemia30.3NBN, CFLAR, BCL6, CARD16, CASP10, HPRT1
19breast cancer30.3TNFAIP3, CASP10, HPRT1, PTPRC, NBN, MDM2
20colorectal cancer30.2CASP10, MDM2, BRAF, CARD16, CFLAR, HPRT1
21lung cancer30.0BRAF, CFLAR, NBN, MDM2
22melanoma29.7MDM2, PTPRC, CASP10, NBN, CFLAR, TIA1
23nodular lymphocyte predominant hodgkin lymphoma11.0
24hepatitis10.7
25diffuse large b-cell lymphoma10.6
26mediastinitis10.6
27hepatitis c10.5
28multiple myeloma10.5
29hematopoietic stem cell transplantation10.5
30mixed cellularity classical hodgkin lymphoma10.5
31lymphocyte-rich classical hodgkin lymphoma10.5
32testicular lymphoma10.5BCL6
33hemolytic anemia10.5
34autoimmune hemolytic anemia10.5
35hepatitis b10.5
36progressive multifocal leukoencephalopathy10.5
37hodgkin's lymphoma, lymphocytic depletion10.5
38t-cell/histiocyte rich large b cell lymphoma10.5
39neutropenia10.4
40composite lymphoma10.4
41gray zone lymphoma10.4
42lymphoblastic leukemia10.4
43central nervous system lymphoma, primary10.4BCL6, PAX5
44mycosis fungoides10.4
45cryoglobulinemia10.4
46pneumonia10.4
47non-hodgkin lymphoma, during pregnancy10.4
48endotheliitis10.4
49primary mediastinal large b-cell lymphoma10.4
50lymphosarcoma10.3BCL6, TNFRSF8

Graphical network of the top 20 diseases related to Hodgkin Lymphoma:



Diseases related to hodgkin lymphoma

Symptoms for Hodgkin Lymphoma

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Symptoms by clinical synopsis from OMIM:

246000

Clinical features from OMIM:

246000

HPO human phenotypes related to Hodgkin Lymphoma:

(show all 21)
id Description Frequency HPO Source Accession
1 lymphoma hallmark (90%) HP:0002665
2 lymphadenopathy hallmark (90%) HP:0002716
3 abnormality of immune system physiology hallmark (90%) HP:0010978
4 hyperhidrosis typical (50%) HP:0000975
5 pruritus typical (50%) HP:0000989
6 weight loss typical (50%) HP:0001824
7 anorexia typical (50%) HP:0002039
8 abnormality of temperature regulation typical (50%) HP:0004370
9 chest pain typical (50%) HP:0100749
10 splenomegaly occasional (7.5%) HP:0001744
11 migraine occasional (7.5%) HP:0002076
12 respiratory insufficiency occasional (7.5%) HP:0002093
13 hemoptysis occasional (7.5%) HP:0002105
14 hepatomegaly occasional (7.5%) HP:0002240
15 incoordination occasional (7.5%) HP:0002311
16 bone pain occasional (7.5%) HP:0002653
17 bone marrow hypocellularity occasional (7.5%) HP:0005528
18 peripheral neuropathy occasional (7.5%) HP:0009830
19 autosomal recessive inheritance HP:0000007
20 congenital cataract HP:0000519
21 scoliosis HP:0002650

Drugs & Therapeutics for Hodgkin Lymphoma

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Genetic Tests for Hodgkin Lymphoma

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Genetic tests related to Hodgkin Lymphoma:

id Genetic test Affiliating Genes
1 Hodgkin Lymphoma22

Anatomical Context for Hodgkin Lymphoma

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MalaCards organs/tissues related to Hodgkin Lymphoma:

31
B cells, T cells, Lymph node, Bone, Bone marrow, Liver, Skin, Lung, Testes, Breast, Myeloid, Monocytes, Endothelial, Spinal cord, Heart, Kidney, Thyroid, Prostate, Brain, Nk cells, Pituitary, Spleen, Small intestine, Testis, Cervix, B lymphoblasts, Tongue, Neutrophil

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Hodgkin Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Hodgkin Lymphoma or affiliated genes

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Publications for Hodgkin Lymphoma

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Articles related to Hodgkin Lymphoma:

(show top 50)    (show all 1453)
idTitleAuthorsYear
1
Dietary patterns and the risk of non-Hodgkin lymphoma. (23659580)
2013
2
Primary non-Hodgkin lymphoma of the bladder. (24369199)
2013
3
Atrazine and nitrate in public drinking water supplies and non-hodgkin lymphoma in nebraska, USA. (23515852)
2013
4
Biodistribution and dosimetry of (177)Lu-tetulomab, a new radioimmunoconjugate for treatment of non-Hodgkin lymphoma. (23256748)
2013
5
The prognostic impact of variant histology in nodular lymphocyte-predominant Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG). (24100447)
2013
6
Unusual hairy cell projections in hepatosplenic T-cell non-Hodgkin lymphoma. (23593648)
2013
7
External validation of a risk model of febrile neutropenia occurrence in patients with non-Hodgkin lymphoma. (23452152)
2013
8
Angiokeratoma corporis diffusum in a patient with Hodgkin lymphoma: a new paraneoplastic skin manifestation? (23278357)
2013
9
Non-Hodgkin lymphoma as an uncommon cause of acute heart failure. (23503834)
2013
10
Treatment of nodular lymphocyte-predominant Hodgkin lymphoma-"do no harm". (24472810)
2013
11
Front-line immunochemotherapy for aggressive non-Hodgkin lymphoma using dose-dense rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone plus granulocyte-macrophage colony stimulating factor and pegfilgrastim as support. (22448918)
2012
12
Analysis of very elderly (a8Y80 years) non-hodgkin lymphoma: impact of functional status and co-morbidities on outcome. (22084970)
2012
13
The association of hepatitis B virus infection with B-cell non-Hodgkin lymphoma - a review. (22432084)
2012
14
Treatment option of bendamustine in combination with rituximab in elderly and frail patients with aggressive B-non-Hodgkin lymphoma: rational, efficacy, and tolerance. (22752146)
2012
15
Assessment of immunovirological features in HIV related non-Hodgkin lymphoma patients and their impact on outcome. (22244256)
2012
16
The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma. (22781692)
2012
17
Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability. (21488163)
2011
18
Results of the Japan Association of Childhood Leukemia Study (JACLS) NHL-98 protocol for the treatment of B-cell non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia in childhood. (21261497)
2011
19
Expression of serine 194-phosphorylated Fas-associated death domain protein correlates with proliferation in B-cell non-Hodgkin lymphomas. (21315423)
2011
20
Non-hodgkin lymphoma in a child with schimke immuno-osseous dysplasia. (23359635)
2011
21
Soluble IL-2RI+ facilitates IL-2-mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma. (21719603)
2011
22
Sexual well-being among survivors of non-Hodgkin lymphoma. (21875831)
2011
23
Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study. (20299965)
2010
24
KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma. (20519630)
2010
25
Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma. (19101572)
2009
26
Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. (19066394)
2009
27
Functional signatures identified in B-cell non-Hodgkin lymphoma profiles. (19863341)
2009
28
A 19-year follow-up of a patient with type 3 ectrodactyly-ectodermal dysplasia-clefting syndrome who developed non-Hodgkin lymphoma. (19716498)
2009
29
Interleukine-2 therapy does not increase the risk of Hodgkin or non-Hodgkin lymphoma in HIV-infected patients: results from FHDH ANRS CO4. (19131886)
2009
30
Non-Hodgkin lymphoma (NHL) in children with Nijmegen Breakage syndrome (NBS). (18937313)
2009
31
Fatal chylous ascites, pericarditis and extensive venous thrombosis, due to an aggressive T cell non-Hodgkin lymphoma. (18679682)
2009
32
Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines. (18541724)
2008
33
The NF-kappaB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs. (18949621)
2008
34
Non-Hodgkin lymphoma related to hereditary nonpolyposis colorectal cancer in a patient with a novel heterozygous complex deletion in the MSH2 gene. (18181177)
2008
35
Paraneoplastic lumbosacral axonal polyradiculopathy preceding the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma: a case report. (18720211)
2008
36
'Precursors' of classical Hodgkin lymphoma in samples of angioimmunoblastic T-cell lymphoma. (18324974)
2008
37
HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma. (17630352)
2007
38
Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6. (17652621)
2007
39
Genetic polymorphisms in the proximal IL-10 promoter and susceptibility to non-Hodgkin lymphoma. (17990180)
2007
40
High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma. (17375124)
2007
41
Outcome of children with nodular lymphocyte predominant Hodgkin lymphoma - a Children's Cancer and Leukaemia Group report. (17760808)
2007
42
Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma. (16740140)
2006
43
Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut. (16738949)
2006
44
Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. (16857995)
2006
45
A putative exonic splicing polymorphism in the BCL6 gene and the risk of non-Hodgkin lymphoma. (16264183)
2005
46
Intensive sequential chemotherapy with hematopoietic growth factor support for non-Hodgkin lymphoma in patients infected with the human immunodeficiency virus. (14770420)
2004
47
Expression profile and prognostic significance of CD24, p53 and p21 in lymphomas. A tissue microarray study of over 600 non-Hodgkin lymphomas]. (15455300)
2004
48
Antibody-targeted therapy: a paradigm of innovative treatment strategies in indolent and aggressive B-cell non-Hodgkin lymphoma. (15548997)
2004
49
The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. (14608905)
2003
50
Therapy-related acute leukemia associated with involvement of 11q23 after high grade non-Hodgkin lymphoma. (9573684)
1998

Variations for Hodgkin Lymphoma

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Clinvar genetic disease variations for Hodgkin Lymphoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1KLHDC8BNM_173546.2(KLHDC8B): c.-158C> Tsingle nucleotide variantPathogenicrs387906223GRCh37Chr 3, 49209095: 49209095

Cosmic variations for Hodgkin Lymphoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
144571TP53haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,Hodgkin lymphoma1

Expression for genes affiliated with Hodgkin Lymphoma

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Search GEO for disease gene expression data for Hodgkin Lymphoma.

Pathways for genes affiliated with Hodgkin Lymphoma

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Pathways related to Hodgkin Lymphoma according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0CFLAR, CASP10
29.9NBN, REL, MDM2
3
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.8MDM2, CASP10, CFLAR
4
Show member pathways
9.8REL, BRAF, TNFAIP3
59.8CFLAR, TNFAIP3, CASP10
6
Show member pathways
9.8CFLAR, TNFAIP3, CASP10
79.8CASP10, TNFAIP3, CFLAR
8
Show member pathways
9.8TNFSF8, TNFRSF8, CASP10
99.8MDM2, CASP10, BCL6
10
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.8MDM2, BCL6, BRAF
11
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.7PDCD1, REL, PTPRC
12
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
9.7TNFSF8, TNFRSF8, REL
139.7BCL6, PAX5, PTPRC
14
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
9.6MDM2, CASP10, REL, CFLAR
159.5MDM2, BCL6, REL, PAX5
16
Show member pathways
9.5TNFSF8, TNFRSF8, TNFAIP3, CASP10
179.5BCL6, REL, BRAF, PTPRC
18
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.5PTPRC, BRAF, REL, BCL6
19
Show member pathways
9.3CFLAR, TNFSF8, TNFRSF8, BRAF, CASP10
20
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.3CASP10, REL, PTPRC, TNFAIP3, CFLAR
21
Show member pathways
Alternative NF-kappaB pathway36
9.2CFLAR, TNFRSF8, TNFAIP3, REL, CASP10
22
Show member pathways
9.1CFLAR, TNFSF8, TNFRSF8, BRAF, CASP10, MDM2

Compounds for genes affiliated with Hodgkin Lymphoma

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Compounds related to Hodgkin Lymphoma according to GeneCards Suite gene sharing:

(show all 41)
idCompoundScoreTop Affiliating Genes
17,12-dimethylbenz(a)anthracene4310.3MDM2, REL
2bpde4310.3MDM2, HPRT1
3methylmethanesulfonate4310.3MDM2, HPRT1, NBN
4mitomycin c4310.2MDM2, HPRT1, NBN
5geldanamycin43 49 59 1213.2CFLAR, BRAF, MDM2
6p0024310.1CFLAR, BRAF, MDM2
7o6-methylguanine4310.1HPRT1, BRAF
8adenine43 24 1212.1TIA1, BRAF, HPRT1
9adriamycin4310.1MDM2, HPRT1, CFLAR
10rituximab43 49 1212.0BCL6, PAX5, CFLAR
11paclitaxel43 49 1212.0CFLAR, BRAF, CASP10, MDM2
12rapamycin4310.0MDM2, BRAF, NBN, CFLAR
13dutp4310.0CFLAR, CARD16, MDM2
14vincristine43 49 1212.0MDM2, BCL6, CFLAR
15imatinib43 49 1211.9MDM2, BCL6, BRAF, CFLAR
16cisplatin43 49 59 1212.9CFLAR, BRAF, HPRT1, CASP10, MDM2
17irinotecan43 49 1211.8CFLAR, BRAF, CARD16, MDM2
18cyclophosphamide43 49 1211.8HPRT1, BCL6, MDM2
19[alcl]439.8TNFRSF8, PTPRC, TIA1, PAX5
20camptothecin43 59 1211.8CFLAR, NBN, CARD16, MDM2
215-aza-2deoxycytidine439.8CFLAR, HPRT1, MDM2
22doxorubicin43 49 1211.8CFLAR, NBN, BCL6, MDM2
23oligonucleotide439.8CFLAR, BRAF, PAX5, REL, MDM2
24testosterone43 59 24 1212.7MDM2, HPRT1, PAX5, PTPRC, CFLAR
25phosphatidylinositol439.7CFLAR, NBN, PTPRC, BRAF, MDM2
26arsenite43 2410.7MDM2, TIA1, CFLAR
27h2o2439.6CFLAR, TNFAIP3, PTPRC, HPRT1, MDM2
28etoposide43 49 59 1212.6CFLAR, NBN, HPRT1, CARD16, MDM2
29thymidine43 2410.6CFLAR, TNFRSF8, HPRT1, MDM2
30valine439.6MDM2, HPRT1, BRAF
31cyclosporin a43 28 5911.6CFLAR, TNFRSF8, PTPRC, REL
32cycloheximide439.5CFLAR, TNFAIP3, PTPRC, BCL6, MDM2
33nitric oxide43 24 1211.4CFLAR, TNFAIP3, REL, CARD16, MDM2
34estrogen439.3PTPRC, BRAF, REL, BCL6, MDM2
35zinc43 2410.3TNFRSF8, TNFAIP3, PAX5, REL, BCL6, MDM2
36cysteine439.1CFLAR, PTPRC, REL, HPRT1, CASP10, CARD16
37paraffin439.1TNFRSF8, PTPRC, TIA1, BRAF, PAX5, BCL6
38threonine438.9CFLAR, NBN, TNFRSF8, PTPRC, TIA1, BRAF
39calcium43 49 24 1211.9CFLAR, TNFRSF8, PTPRC, BRAF, PAX5, REL
40tyrosine438.2CFLAR, TNFRSF8, PTPRC, BRAF, PAX5, REL
41serine437.6MDM2, CFLAR, NBN, TNFRSF8, PTPRC, TIA1

GO Terms for genes affiliated with Hodgkin Lymphoma

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Cellular components related to Hodgkin Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CD95 death-inducing signaling complexGO:00312659.9CASP10, CFLAR
2replication forkGO:00056579.9BCL6, NBN
3ripoptosomeGO:00973429.7CASP10, CFLAR

Biological processes related to Hodgkin Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.8CASP10, REL, CFLAR
2regulation of germinal center formationGO:00026349.8TNFAIP3, BCL6
3negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:019020429.7TNFAIP3, CFLAR
4apoptotic processGO:00069159.1PDCD1, CASP10, TIA1, TNFAIP3, TNFSF8, CFLAR

Molecular functions related to Hodgkin Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1death effector domain bindingGO:003587710.0CASP10, CFLAR
2protein bindingGO:00055157.1MDM2, CFLAR, NBN, TNFAIP3, PTPRC, FCRL4

Products for genes affiliated with Hodgkin Lymphoma

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Sources for Hodgkin Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet