MCID: HDG009
MIFTS: 23

Hodgkin Lymphoma, Childhood malady

Immune category

Summaries for Hodgkin Lymphoma, Childhood

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33MalaCards
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MalaCards: Hodgkin Lymphoma, Childhood, also known as childhood hodgkin's lymphoma, is related to non-hodgkin lymphoma, childhood and nijmegen breakage syndrome. An important gene associated with Hodgkin Lymphoma, Childhood is NBN (nibrin), and among its related pathways are DNA Damage and p53 signaling pathway. The compounds hydroxyurea and bpde have been mentioned in the context of this disorder. Affiliated tissues include t cells, b lymphoblasts and b cells, and related mouse phenotypes are tumorigenesis and reproductive system.

Aliases & Classifications for Hodgkin Lymphoma, Childhood

Sources:
43NIH Rare Diseases, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

hodgkin lymphoma, childhood 43
childhood hodgkin's lymphoma 43 61


Related Diseases for Hodgkin Lymphoma, Childhood

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Hodgkin Lymphoma, Childhood:



Diseases related to hodgkin lymphoma, childhood

Clinical Features for Hodgkin Lymphoma, Childhood

Drugs & Therapeutics for Hodgkin Lymphoma, Childhood

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hodgkin Lymphoma, Childhood

Anatomical Context for Hodgkin Lymphoma, Childhood

Sources:
33MalaCards
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MalaCards organs/tissues related to Hodgkin Lymphoma, Childhood:

33
T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Hodgkin Lymphoma, Childhood or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Hodgkin Lymphoma, Childhood:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5NBN, MDM2, HPRT1
2MP:00053898.5NBN, HPRT1, MDM2
3MP:00053828.4NBN, MDM2, HPRT1
4MP:00053808.2HPRT1, MDM2, NBN

Publications for Hodgkin Lymphoma, Childhood

Sources:
51PubMed
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Articles related to Hodgkin Lymphoma, Childhood:

(show all 33)
idTitleAuthorsYear
1
Neurological complication of non Hodgkin lymphoma in childhood: experience from a single center in Turkey. (23989474)
2013
2
Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study. (23729503)
2013
3
A prospective analysis of body size during childhood, adolescence, and adulthood and risk of non-Hodgkin lymphoma. (23803416)
2013
4
Characterization of insulin resistance in young adult survivors of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma. (22967316)
2013
5
Endocrine late sequelae in long-term survivors of childhood non-Hodgkin lymphoma. (22048153)
2012
6
Autoimmune hemolytic anemia and immune thrombocytopenia as unusual presentations of childhood Hodgkin lymphoma: a case report and review of the literature. (22258348)
2012
7
Outcome of childhood relapsed or refractory mature B-cell non-Hodgkin lymphoma and acute lymphoblastic leukemia. (22448922)
2012
8
Results of the Japan Association of Childhood Leukemia Study (JACLS) NHL-98 protocol for the treatment of B-cell non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia in childhood. (21261497)
2011
9
Non-Hodgkin lymphoma in childhood and adolescence: frequency and distribution of immunomorphological types from a tertiary care center in South India. (21633853)
2011
10
Immunohistochemical expression of procaspase-3 and its clinical significance in childhood non-Hodgkin lymphomas. (20722551)
2011
11
Evaluation of coronary artery disease by computed tomography angiography in patients treated for childhood Hodgkin's lymphoma. (20038721)
2010
12
Leukemia, non-Hodgkin's lymphoma, and Wilms tumor in childhood: the role of birth weight. (20101509)
2010
13
Low apoptotic index & bak expression in EBV-associated childhood classical Hodgkin lymphoma. (20090100)
2009
14
FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma. (19245433)
2009
15
Pre-treatment serum levels of interleukin-10, interleukin-12 and their ratio predict response to therapy and probability of event-free and overall survival in childhood soft tissue sarcomas, Hodgkin's lymphomas and acute lymphoblastic leukemias. (19376105)
2009
16
Endocrine and metabolic disorders in young adult survivors of childhood acute lymphoblastic leukaemia (ALL) or non-Hodgkin lymphoma (NHL). (18429947)
2008
17
Role of gelatinases (MMP-2 and MMP-9), TIMP-1, vascular endothelial growth factor (VEGF), and microvessel density on the clinicopathological behavior of childhood non-Hodgkin lymphoma. (18231955)
2008
18
Immunohistochemical expression of angiogenic cytokines in childhood Hodgkin lymphoma. (18207652)
2008
19
Infectious mononucleosis, childhood social environment, and risk of Hodgkin lymphoma. (17332371)
2007
20
Late effects of treatment on growth in childhood non-Hodgkin's lymphoma. (16923558)
2006
21
ATM alterations in childhood non-Hodgkin lymphoma. (16631465)
2006
22
Fathers' occupational contacts and risk of childhood leukemia and non-hodgkin lymphoma. (15097020)
2004
23
Relationship between the expression of murine double minute 2 oncogene and non-Hodgkin lymphoma in childhood]. (15733365)
2004
24
p53 protein expression does not correlate with EBV status in childhood B non-Hodgkin lymphomas. (15236276)
2004
25
DNA sequence profile of TP53 gene mutations in childhood B-cell non-Hodgkin's lymphomas: prognostic implications. (12890146)
2003
26
Psychological outcomes in long-term survivors of childhood leukemia, Hodgkin's disease, and non-Hodgkin's lymphoma: a report from the Childhood Cancer Survivor Study. (12093945)
2002
27
Expression of adhesion molecules LFA-1, ICAM-1, CD44, and L-selectin in childhood non-Hodgkin lymphomas. (11241437)
2001
28
Acquired immunodeficiency syndrome presenting as childhood non-Hodgkin's lymphoma. (11876380)
2001
29
Testicular disease in childhood B-cell non-Hodgkin's lymphoma: the French Society of Pediatric Oncology experience. (11331318)
2001
30
No evidence for a major role of heterozygous deletion 657del5 within the NBS1 gene in the pathogenesis of non-Hodgkin's lymphoma of childhood and adolescence. (10848790)
2000
31
Large cell non-Hodgkin lymphoma of childhood: Analysis of 78 consecutive patients enrolled in 2 consecutive protocols at the Memorial Sloan-Kettering Cancer Center. (10618623)
2000
32
Effect of high-dose methotrexate on plasma hypoxanthine and uridine levels in patients with acute leukemia or non-Hodgkin lymphoma in childhood. (1434805)
1992
33
Cranial nerve palsy in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma. (2013032)
1991

Genetic Variations for Hodgkin Lymphoma, Childhood

Expression for genes affiliated with Hodgkin Lymphoma, Childhood

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hodgkin Lymphoma, Childhood

Search GEO for disease gene expression data for Hodgkin Lymphoma, Childhood.

Pathways for genes affiliated with Hodgkin Lymphoma, Childhood

Sources:
4Cell Signaling Technology, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Hodgkin Lymphoma, Childhood according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.0NBN, MDM2
2
Hide members
9.0NBN, MDM2
39.0NBN, MDM2

Compounds for genes affiliated with Hodgkin Lymphoma, Childhood

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB
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Compounds related to Hodgkin Lymphoma, Childhood according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1hydroxyurea45 50 1111.6HPRT1, NBN
2bpde459.5MDM2, HPRT1
3benzo(a)pyrene459.4MDM2, HPRT1
4nucleoside459.4HPRT1, MDM2
5thymidylate459.4MDM2, HPRT1
6adriamycin459.4HPRT1, MDM2
7cyclophosphamide45 50 1111.4MDM2, HPRT1
8curcumin459.4MDM2, HPRT1
95-aza-2deoxycytidine459.3HPRT1, MDM2
10valine459.3HPRT1, MDM2
11camptothecin45 60 1111.3NBN, MDM2
12glyceraldehyde 3-phosphate459.3HPRT1, MDM2
13guanine45 11 2411.2MDM2, HPRT1
14methotrexate45 50 1111.2MDM2, HPRT1
15pyrophosphate45 2410.1HPRT1, MDM2
16Adenosine monophosphate11 2410.0HPRT1, MDM2
17methylmethanesulfonate458.9NBN, HPRT1, MDM2
18mitomycin c458.8NBN, HPRT1, MDM2
19etoposide45 50 60 1111.8NBN, MDM2, HPRT1
20phosphoric acid45 249.8HPRT1, MDM2
21serine458.5NBN, MDM2, HPRT1

GO Terms for genes affiliated with Hodgkin Lymphoma, Childhood

Products for genes affiliated with Hodgkin Lymphoma, Childhood

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hodgkin Lymphoma, Childhood

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet