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MCID: HDG007

Hodgkin's Lymphoma malady
22 drugs, 768 genes, 25 tissues, 915 related diseases, 29 phenotypes, 1352 articles, clinical trials.

Summaries for Hodgkin's Lymphoma

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6Disease Ontology, 23MedlinePlus, 44Wikipedia, 33OMIM, 22MalaCards
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MedlinePlus: Hodgkin disease is a type of lymphoma. lymphoma is cancer of lymph tissue found in the lymph nodes, spleen, liver, and bone marrow. the first sign of hodgkin disease is often an enlarged lymph node. the disease can spread to nearby lymph nodes. later it may spread to the lungs, liver or bone marrow. the cause is unknown. hodgkin disease is rare. symptoms include painless swelling of the lymph nodes in the neck, armpits, or groin fever and chills night sweats weight loss loss of appetite itchy skin doctors can diagnose hodgkin disease with a biopsy. this involves removing and examining a piece of tissue under a microscope. treatment varies depending on how far the disease has spread and often includes radiation therapy or chemotherapy. the earlier the disease is diagnosed, the more effective the treatment. in most cases, hodgkin disease can be cured. nih: national cancer institute23

MalaCards: Hodgkin's Lymphoma, also known as hodgkin disease, is related to non-hodgkin lymphoma and leukemia. An important gene associated with Hodgkin's Lymphoma is TNFSF8 (tumor necrosis factor (ligand) superfamily, member 8), and among its related pathways are STAT3 Pathway and Apoptosis and Autophagy. The drugs cyclophosphamide and cisplatin pwdr [va product] and the compounds estrogen and progesterone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are cellular and homeostasis/metabolism.

Disease Ontology: A lymphoma that is marked by the presence of a type of cell called the reed-sternberg cell.6

Wikipedia: Hodgkin\'s lymphoma, also known as Hodgkin lymphoma and previously known as Hodgkin\'s disease, is a...44 more...

OMIM: 236000

Aliases & Descriptions for Hodgkin's Lymphoma

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6Disease Ontology, 30NIH Rare Diseases, 32Novoseek , 23MedlinePlus, 43UMLS, 33OMIM, 8DISEASES, 40SNOMED-CT, 27NCIt, 19ICD9CM, 24MeSH
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Aliases & Descriptions:

hodgkin's lymphoma 6 30
hodgkin disease 6 30 32 23 43
hodgkin lymphoma 30 33
hodgkin's disease of lymph nodes of inguinal region and/or lower limb 43
hodgkin's disease of intrapelvic lymph nodes 43
stage ii subdiaphragmatic hodgkin lymphoma 6
stage i subdiaphragmatic hodgkin lymphoma 6
lymphoma, hodgkin's 30
hodgkins lymphoma 8
hodgkin's sarcoma 6
hl 6

Related Diseases for Hodgkin's Lymphoma

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13GeneCards, 14GeneDecks
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Diseases related to hodgkin's lymphoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 912)
idRelated DiseaseScoreTop Affiliating Genes
1non-hodgkin lymphoma151.5PIM2, PIK3CA, PIM1, SH2D1A, RFC1, NCF2
2leukemia114.7PIM2, PIK3CA, PIK3R1, PIK3CG, PIM1, SH2D1A
3carcinoma105.8PIM2, PIK3CA, PIK3R1, PIK3CG, PIM1, KLF4
4lymphocytic leukemia86.6PIM2, PIK3CA, PIK3CG, PDCD1LG2, REL, RELB
5prostatitis84.2PIM2, PIK3CA, PIK3R1, PIK3CG, PIM1, KLF4
6myeloma80.7PIM2, PIK3CA, PIK3R1, PIK3CG, NCOR2, REL
7adenocarcinoma79.9PIM2, PIK3CA, PIK3R1, PIK3CG, PIM1, KLF4
8neuronitis76.2PIK3CA, PIK3R1, PIK3CG, PIM1, SH2D1A, KLF4
9melanoma75.4PIK3CA, PIK3R1, PIK3CG, PIM1, PDCD1, PDCD1LG2
10hepatocellular carcinoma75.4PIM2, PIK3CA, PIK3R1, PIK3CG, PDCD1, PDCD1LG2
11myeloid leukemia75.2PIM2, PIK3CA, PIK3R1, PIK3CG, PIM1, NCOR2
12multiple myeloma75.1PIK3CA, PIK3R1, PIK3CG, NCOR2, REL, RELB
13lupus erythematosus75.1PIK3CG, NCF2, PDCD1, PDCD1LG2, REL, KIR2DS3
14gastric cancer71.9PIK3CA, PIK3R1, PIK3CG, PIM1, KLF4, RFC1
15thyroiditis71.4PIK3CA, PIK3R1, PIK3CG, KLF4, RFC1, NCOR2
16lymphoblastic leukemia69.7PIK3CA, PIK3CG, RFC1, KITLG, KIR3DL1, PCNA
17diffuse large b-cell lymphoma63.8PIK3CA, PIK3CG, PIM1, REL, CNR2, RB1
18sarcoma63.3PIK3CA, PIK3R1, PIK3CG, RELB, KITLG, PCNA
19tuberculosis63.2PIM2, PIK3CG, PIM1, SH2D1A, PDCD1, PDCD1LG2
20b-cell non-hodgkin lymphoma62.1SH2D1A, RB1, RBBP7, VEGFA, MYC, BMI1
21neuroblastoma61.5PIK3CA, PIK3R1, PIK3CG, KLF4, NCF2, NCOR2
22hypoxia60.6PIK3CA, PIK3R1, PIK3CG, PIM1, KITLG, PCNA
23acute myeloid leukemia60.5PIM2, PIK3CA, PIK3R1, PIK3CG, PIM1, NCOR2
24acute leukemia59.4PIK3CA, NCOR2, KITLG, RB1, SELL, NAT2
25anemia59.0PIM1, SH2D1A, PDCD1, KITLG, PCNA, RB1
26cholesterol57.9PIK3CA, PIK3R1, PIK3CG, NCF2, NCOR2, REL
27b-cell lymphomas57.2PIM1, REL, CNR1, RB1, NBN, MYC
28fibrosis56.9PIK3CA, PIK3CG, NCF2, CNR1, CNR2, KITLG
29nasopharyngitis56.5PIK3CA, PIK3CG, PDCD1, RELB, KIR2DS5, KIR2DL1
30myelodysplastic syndrome54.1PIK3CG, KITLG, KIR3DL1, PCNA, RB1, SELL
31pneumonia54.1SELE, SELL, SERPINB9, VIM, BSG, VEGFA
32mantle cell lymphoma53.5PIM2, PIK3CA, PIK3CG, PIM1, CNR1, CNR2
33chronic lymphocytic leukemia53.2REL, SELL, MYB, BIRC2, BIRC3, BIRC5
34leukemia/lymphoma52.7PIM2, PIK3CA, PIK3CG, RFC1, PDCD1, PDCD1LG2
35obesity52.1PIK3CA, PIK3R1, PIK3CG, NCOR2, CNR1, CNR2
36retinitis52.1PIK3CA, PIK3CG, PIM1, CNR1, CNR2, KITLG
37colon carcinoma51.0PIK3CA, PIK3R1, PIK3CG, KLF4, CNR1, KITLG
38anaplastic large cell lymphoma50.7PIK3CA, PCNA, RB1, SERPINB9, BSG, MYC
39ischemia49.8PIK3CA, PIK3CG, KLF4, CNR1, CNR2, KITLG
40retinoblastoma49.4PIK3CA, PIK3R1, PIK3CG, RFC1, KITLG, PCNA
41peritonitis49.4RELB, KIR2DL1, KIR2DL3, KITLG, KIR3DL1, PCNA
42immunodeficiency49.3PDCD1, KIR3DL1, SELL, MYD88, BMP6, PARP1
43systemic lupus erythematosus48.0PDCD1, SELE, NAT2, CLU, BCR, LCK
44acute lymphoblastic leukemia47.7KITLG, KIR3DL1, RB1, NBN, SELL, LMO2
45arthritis46.9PIK3CG, SH2D1A, RFC1, NCF4, PDCD1, PDCD1LG2
46sarcoidosis46.9KIR2DL3, SELE, SELL, VIM, VEGFA, VDR
47noonan syndrome46.5PIK3CG, PIM1, CNR1, KITLG, PCNA, BSG
48thrombosis46.4PIK3CG, RFC1, PCNA, SELE, SELL, SELPLG
49blindness46.4PIK3CG, CNR1, SELE, VEGFA, VDR, CLU
50burkitt's lymphoma46.0SH2D1A, MYC, MYCN, MYB, BMI1, BMP6

Graphical network of the top 20 diseases related to hodgkin's lymphoma:



Graphical network of diseases related to hodgkin's lymphoma

Clinical Features for Hodgkin's Lymphoma

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33OMIM
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Clinical features from OMIM: 236000

Drugs & Therapeutics for Hodgkin's Lymphoma

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for hodgkin's lymphoma

Drug clinical trials:

Search ClinicalTrials for hodgkin's lymphoma

Search NIH Clinical Center for hodgkin's lymphoma

Search CenterWatch for hodgkin's lymphoma

Inferred drug relations via UMLS/NDF-RT:

43 28 bleomycin, bleomycin sulfate, carmustine, chlorambucil, cisplatin, cisplatin pwdr [va product], cyclophosphamide, dacarbazine, ifosfamide, lomustine, mechlorethamine, mechlorethamine hydrochloride, procarbazine, procarbazine hydrochloride, sargramostim, streptozocin, vinblastine, vinblastine sulfate, vincristine, vincristine sulfate, vinorelbine, vinorelbine tartrate

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for hodgkin's lymphoma:
Blood stem cell transplantation in Hodgkin's/non-Hodgkin's lymphoma, multiple myeloma or chronic lymphocytic leukemia patients
Donor peripheral blood stem cell transplantation in patients with hematologic malignancies
NiCord®, ex vivo-expanded population of umbilical cord blood-derived stem/progenitor cells
StemEx® - umbilical cord blood stem and progenitor cells for the treatment of hematological malignancies
Embryonic/Adult Cultured Cells Related to hodgkin's lymphoma:
Peripheral blood/mobilized hematopoietic stem cells, PMIDs: 19015394, 17916744, 18794548
Peripheral blood/mobilized hematopoietic stem cells, PMIDs: 12171484, 19925877, 18489989

Genetic Tests for Hodgkin's Lymphoma

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Anatomical Context for Hodgkin's Lymphoma

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21LifeMap Discovery™, 22MalaCards
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MalaCards organs/tissues related to hodgkin's lymphoma:

22
Bone marrow, Lymph node, Spleen, Brain, Heart, Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Breast, Skin, Prostate, Testis, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Testis germ

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Embryonic and adult cells/anatomical compartments related to hodgkin's lymphoma:
id Organ / Tissue -> Anatomical Compartment -> Cell Relevance
1 Bone -> Bone Marrow -> Hematopoietic Stem Cells Potential therapeutic candidate
2 Blood -> Peripheral Blood -> Mature B Cells Potential therapeutic candidate, affected by disease

Phenotypes for genes affiliated with Hodgkin's Lymphoma

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25MGI
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MGI Mouse Phenotypes related to hodgkin's lymphoma:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1cellular phenotypeMP:000538441.0PIM2, PIK3CA, PIK3R1, PIK3CG, PIM1, SH2D1A
2homeostasis/metabolism phenotypeMP:000537637.2PIK3CA, PIK3R1, PIK3CG, KLF4, NCOR2, PDCD1LG2
3mortality/agingMP:001076833.9PIK3CA, KLF4, NCF4, NCOR2, PDCD1, PDCD1LG2
4growth/size phenotypeMP:000537829.0PIM2, PIK3CA, PIK3R1, PIK3CG, PIM1, NCOR2
5cardiovascular system phenotypeMP:000538528.6PIK3CA, PIK3R1, PIK3CG, NCOR2, PDCD1, REL
6immune system phenotypeMP:000538728.5PIM2, SH2D1A, NCF4, REL, RELB, CNR2
7tumorigenesisMP:000200624.2PIK3CA, PIK3R1, KLF4, PDCD1LG2, KITLG, RB1
8nervous system phenotypeMP:000363122.8PDCD1, REL, CNR1, KITLG, PCGF2, RB1
9normal phenotypeMP:000287322.5PIK3R1, KLF4, RBL2, SELE, SERPING1, NAT1
10integument phenotypeMP:001077122.2PIK3CG, KLF4, REL, RELB, CNR1, CNR2
11behavior/neurological phenotypeMP:000538621.0PIK3CA, KLF4, NCOR2, RELB, CNR1, RB1
12reproductive system phenotypeMP:000538920.6PIK3CA, KLF4, RBL2, NBN, NAT1, BRCA1
13skeleton phenotypeMP:000539020.5PIK3CG, REL, CNR1, KITLG, RB1, RBL2
14vision/eye phenotypeMP:000539120.4PIK3CA, PDCD1, KITLG, PCGF2, RB1, RBL2
15digestive/alimentary phenotypeMP:000538120.3KLF4, NCOR2, REL, RELB, KITLG, PCGF2
16muscle phenotypeMP:000536920.0PIK3CA, PIK3R1, PIK3CG, PDCD1, RELB, RB1
17embryogenesis phenotypeMP:000538019.0PIK3CA, REL, PCGF2, RBBP7, RBL2, NBN
18liver/biliary system phenotypeMP:000537017.8NCOR2, REL, RELB, VEGFA, LMO2, MYCN
19endocrine/exocrine gland phenotypeMP:000537916.6KLF4, RELB, RBL2, NBN, SELL, BRCA1
20renal/urinary system phenotypeMP:000536716.3PDCD1, SELPLG, BRAF, BRCA1, LMO2, MYCN
21no phenotypic analysisMP:000301215.7PIK3R1, PDCD1LG2, CNR1, PCNA, RB1, RBL2
22adipose tissue phenotypeMP:000537515.4PIK3CA, PIK3R1, NCOR2, CNR1, RB1, BRAF
23respiratory system phenotypeMP:000538815.3REL, RELB, SELL, BRCA1, MYCN, RAG1
24limbs/digits/tail phenotypeMP:000537115.1RELB, KITLG, PCGF2, RB1, RBL2, BRCA1
25hearing/vestibular/ear phenotypeMP:000537714.6KITLG, RB1, VDR, MYC, MYD88, RAG1
26craniofacial phenotypeMP:000538214.5KLF4, NCOR2, KITLG, PCGF2, NBN, MYCN
27pigmentation phenotypeMP:000118613.3KITLG, RB1, BRAF, BRCA1, MYC, RAG1
28other phenotypeMP:000539512.6RELB, CNR1, CLU, KDR, LEPR, LDLR
29hematopoietic system phenotypeMP:0005397INFPIM2, PIM1, SH2D1A, PDCD1, PDCD1LG2, PCGF2

Publications for genes affiliated with Hodgkin's Lymphoma

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35PubMed
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Articles related to hodgkin's lymphoma:

(show top 50)    (show all 1352)
idTitleAuthorsYearAffiliating Genes
1Heterogeneous expression of Src tyrosine kinases Lyn, Fyn and Syk in classical Hodgkin lymphoma: prognostic implications. (21749309)MartA-n P.... Bellas C.2011FYN, SYK, LYN
2Tissue-microarray based immunohistochemical analysis of survival pathways in nodular sclerosing classical Hodgkin lymphoma as compar ed with Non-Hodgkin's lymphoma. (20369041)De J.... Brown R.E.2010MAPK1, CHRDL1
3Serum soluble interleukin-2 receptor, beta2-microglob ulin, lactate dehydrogenase and erythrocyte sedimentation rate in children with Hodgkin's lymphoma. (19874554)Bien E.... Balcerska A.2009B2M
4Analysis of Aurora B kinase in non-Hodgkin lymphoma. (19823168)Ikezoe T.... Yokoyama A.2009AURKB
5Epstein-Barr virus-associated proliferative disorder presenting as Hodgkin's lymphoma and developing as aggressive natural killer-ce ll leukemia 19 years later: a case report of composite lymphoma. (19269751)Oka K.... Mori N.2009GZMB, TIA1
6FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma. (19245433)Park M.J.... Hayashi Y.2009NOTCH1, FBXW7
7Pre-treatment serum levels of interleukin-10, interle ukin-12 and their ratio predict response to therapy and probability of event-fr ee and overall survival in childhood soft tissue sarcomas, Hodgkin's lymphomas and acute lymphoblastic leukemias. (19376105)Bien E.... Stepinski J.2009IL10, IL12A
8Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in t umor cell growth and microenvironmental interactions of Hodgkin's lymphoma. (19391137)Cattaruzza L.... Aldinucci D.2009IL7R, IL7
9CXCL12 rs1801157 polymorphism in patients with breast cancer, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. (19927352)de Oliveira K.B.... Watanabe M.A.2009CXCL12
10Prognostic significance of CD20 expression in Hodgki n and Reed-Sternberg cells of classical Hodgkin's Lymphoma (19000453)Fu X.H.... Lin T.Y.2008MS4A1
11Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells. (17720884)Flavell J.R.... Murray P.G.2008TGFB1, PTPRK
12Salvage chemotherapy with rituximab DHAP for relapsed non-Hodgkin lymphoma: a phase II trial in the North Central Cancer Treatment G roup. (18569634)Witzig T.E.... Reeder C.B.2008CSF3
13Rituximab in relapsed lymphocyte-predominant Hodgkin lymphoma: long-term results of a phase 2 trial by the German Hodgkin Lymphoma Study Group (GHSG). (17938252)Schulz H.... Reiser M.2008CHRDL1
14Biologic features of Hodgkin lymphoma and the develop ment of biologic prognostic factors in Hodgkin lymphoma: tumor and microenviron ment. (18798102)Hsi E.D.2008CHRDL1
15P-glycoprotein expression in non-Hodgkin's lymphomas of human immunodeficiency virus infected patients. (17157997)Tanaka P.Y.... Calore E.E.2007ABCB1
16Immune mechanisms in non-Hodgkin lymphoma: joint effects of the TNF G308A and IL10 T3575A polymorphisms with non-Hodgkin lymphoma risk factors. (17510437)Wang S.S.... Hartge P.2007TNF, IL10
17Polymorphisms in immune function genes and risk of non-Hodgkin lymphoma: findings from the New South Wales non-Hodgkin Lymphoma Study. (17056605)Purdue M.P.... Armstrong B.K.2007TNF
18Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. (16857995)Hill D.A.... Rothman N.2006LIG4, RAG1
19Expression of bcl-2 in classical Hodgkin's lymphoma: an independent predictor of poor outcome. (15809450)Sup S.J.... Hsi E.D.2005BCL2
20Combination chemotherapy with adriamycin, cyclophosph amide, vincristine, methotrexate, etoposide and dexamethasone (ACOMED) followed by involved field radiotherapy induces high remission rates and durable long-t erm survival in patients with aggressive malignant non-Hodgkin's lymphomas: lon g-term follow-up of a pilot study. (16353313)RAPdel S.... Reiser M.2005CSF3
21A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma. (15744236)Leemhuis T.... Negrin R.S.2005IL2, IFNG
22Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines. (14982841)Dukers D.F.... Raaphorst F.M.2004RING1, EED, CBX4
23Lack of prognostic significance of BCL2 and p53 protein overexpression in elderly patients with diffuse large B-cell non-Hodgkin's lymphoma: results from a population-based non-Hodgkin's lymphoma registry. (15061204)Maartense E.... Noordijk E.M.2004TP53, BCL2
24Clinical relevance of circulating angiogenic factors in patients with non-Hodgkin's lymphoma or Hodgkin's lymphoma. (15120936)Giles F.J.... Albitar M.2004HGF, FGF2, VEGFA
25Comparison of initial characteristics and long-term outcome of patients with lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma at clinical stages IA and IIA prospectively treated by brief anthracycline-based chemotherapies plus extended high-dose irradiation. (15231567)Feugier P.... Andrieu J.M.2004CHRDL1
26An elderly case of non-Hodgkin's lymphoma (NHL) with hypercalcemia (12708052)Ota H.... Orimo H.2003CALCA, PTHLH
27Association between SV40 and non-Hodgkin's lymphoma. (15202523)Butel J.S.... Kozinetz C.A.2003TAG
28SV40 in human brain cancers and non-Hodgkin's lymphoma. (12910253)Vilchez R.A.... Butel J.S.2003TAG
29Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma. (12670918)Brauninger A.... Hansmann M.L.2003CHRDL1
30Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma. (12393409)Wlodarska I.... Hagemeijer A.2003BCL6
3114-day variant of the bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone regimen in advanced-stage Hodgkin's lymphoma: results of a pilot study of the German Hodgkin's Lymphoma Study Group. (12721249)Sieber M.... Diehl V.2003CSF3
32Detection of polyomavirus simian virus 40 tumor antig en DNA in AIDS-related systemic non-Hodgkin lymphoma. (11832678)Vilchez R.A.... Butel J.S.2002TAG
33High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease. (11895764)Oksenhendler E.... Meignin V.2002IL6
34Mobilization of peripheral blood stem cells with high-dose cyclophosphamide or the DHAP regimen plus G-CSF in non-Hodgkin's lymphoma. (11896424)Pavone V.... Liso V.2002CSF3
35Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma. (11956621)Retzlaff S.... Berdel W.E.2002FLT3, IL8, FLT3LG
36TARC, a CC chemokine, is frequently expressed in classic Hodgkin's lymphoma but not in NLP Hodgkin's lymphoma, T-cell-rich B-cell lymphoma, and most cases of anaplastic large cell lymphoma. (11420464)Peh S.C.... Poppema S.2001CCL17
37Study on expression of caspase-3 and bcl-2 proteins and their relations with cell apoptosis and proliferation in non-Hodgkin's lymphoma (11866986)Zhang W.... He P.2001BCL2, CASP3, PCNA
38cdc25a and the splicing variant cdc25b2, but not cdc25B1, -B3 or -C, are over-expressed in aggressive human non-Hodgkin's lymphomas. (10754492)Hernandez S.... Campo E.2000CDC25A, MS4A1
39Correlation and prognostic value of serum soluble ICAM-1, beta-2 microglobulin, and IL-2alphaR levels in non-Hodgkin's lymphoma. (10342582)Perez-Encinas M.... Bello J.L.1999B2M
40Frequent hepatic involvement in adult T cell leukemia: comparison with non-Hodgkin's lymphoma. (9322895)Yamada Y.... Tomonaga M.1997GPT
41Analysis of p18INK4C in adult T-cell leukaemia and non-Hodgkin's lymphoma. (9401081)Hatta Y.... Koeffler H.P.1997CDKN2C
42Recombinant human erythropoietin in transfusion-depen dent anemic patients with multiple myeloma and non-Hodgkin's lymphoma--a random ized multicenter study. The European Study Group of Erythropoietin (Epoetin Bet a) Treatment in Multiple Myeloma and Non-Hodgkin's Lymphoma. (8639883)Osterborg A.... Peest D.1996EPO
43MDR-1 expression in non-Hodgkin's lymphomas is unrelated to treatment intensity or response to therapy. (8535196)Finnegan M.C.... Goyns M.H.1995ABCB1
44Differential expression of two ICAM-1 epitopes and LFA-1 chains in B-cell non-Hodgkin's lymphomas. (7522192)Vacca A.... Dammacco F.1994ICAM1
45Non-Hodgkin's lymphoma in four children infected with the human immunodeficiency virus. Association with Epstein-Barr Virus and trea tment. (8275430)Nadal D.... Seger R.A.1994TRB@
46Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: implications for mechanisms of tumor progression. (8220113)Reed J.C.... Tanaka S.1993BCL2
47G-CSF in practice: malignant non-Hodgkin's lymphomas (7686283)Rossi J.F.1993CSF3
48Simultaneous assay of adenosine deaminase and purine nucleoside phosphorylase activity as possible biochemical means to detect non-Hodgkin lymphomas of the oral cavity. (1606542)Maeda K.... Mizuno A.1992ADA, PNP
49The detection of specific gene rearrangements in non-Hodgkin's lymphoma using the polymerase chain reaction. (1419624)Corbally N.... Carney D.N.1992BCL2, IGH@
50Analysis of T-cell receptor and immunoglobulin gene rearrangements in the diagnosis of Hodgkin's and non-Hodgkin's lymphoma. (2391586)Gledhill S.... Jarrett R.F.1990TRB@

Expression for genes affiliated with Hodgkin's Lymphoma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Hodgkin's Lymphoma

Pathways for genes affiliated with Hodgkin's Lymphoma

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36QIAGEN, 3Cell Signaling Technology, 20KEGG, 10EMD Millipore, 41Thomson Reuters, 37R&D Systems
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Pathways related to hodgkin's lymphoma according to GeneDecks:

(show top 50)    (show all 319)
idPathwayScoreTop Affiliating Genes
1STAT3 Pathway3618.9PIM1, BRAF, MYC, BMP6, RAF1, RAC1
2Apoptosis and Autophagy318.0PIM2, PIM1, MYC, MYCN, BID, BIK
3Tec Kinases Signaling3617.9PIK3R1, KITLG, VEGFC, MYD88, BMP6, RAC1
4Akt Signaling3616.0PIK3R1, PIK3CG, VEGFC, RAF1, CHUK, CD28
5Tuberculosis2016.0VDR, MYD88, RAF1, BID, BCL10, BCL2
6Cell Cycle / Checkpoint Control315.7PCNA, RB1, NBN, BRCA1, RAD50, BLM
7TGF-Beta Pathway3615.4PIK3R1, KITLG, VEGFC, BMP6, KDR, BCL2
8Rho Family GTPases3615.2PIK3R1, NCF2, KITLG, VIM, VEGFC, BMP6
9Cellular Apoptosis Pathway3615.0PIK3R1, KITLG, VEGFC, BMP6, BID, BIRC2
10Glucocorticoid Receptor Signaling3614.8NCOR2, BMP6, BCL2, BAX, CEBPA, JUN
11NF-KappaB Family Pathway3614.1PIK3R1, REL, RELB, KITLG, VEGFC, MYD88
12Toxoplasmosis2014.0PIK3CA, PIK3R1, PIK3CG, MYD88, BIRC2, BIRC3
13Intestinal immune network for IgA production2013.9CD28, CD86, CD40LG, CD80, CD40, ITGA4
14Apoptotic Pathways Triggered By HIV13613.7BID, BIRC2, BIRC3, BCL2, BCL2L1, CHUK
15Apoptosis through Death Receptors3613.7BID, BIRC2, BIRC3, BCL2, CHUK, BAX
16SOCS Pathway3613.5VEGFC, BMP6, BCL2, BAX, JAK2, CD80
17p53 Mediated Apoptosis3613.5PIK3R1, KITLG, VEGFC, BMP6, BID, KDR
18Apoptosis and survival Apoptotic TNF-family pathways1013.5BID, BIRC2, BCL2, BCL2L1, BAX, XIAP
19Apoptosis and survival FAS signaling cascades1013.4BID, BIRC2, PARP1, BCL2, BCL2L11, BAX
20Apoptosis and survival_FAS signaling cascades4113.4BID, BIRC2, PARP1, BCL2, BCL2L11, BAX
21Chagas disease (American trypanosomiasis)2013.3PIK3CA, PIK3R1, PIK3CG, MYD88, CHUK, CFLAR
22Apoptosis and survival APRIL and BAFF signaling1013.1RELB, BCL2, BCL2A1, BCL2L1, CHUK, FCER2
23Development_IGF-1 receptor signaling4113.1PIK3CA, PIK3R1, REL, RELB, MYC, RAF1
24Nuclear Receptor Activation by Vitamin-A3613.1KITLG, VEGFC, BMP6, KDR, FLT1, FLT4
25Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway1013.0REL, RELB, BCL2, BCL2A1, BCL2L1, CHUK
26Caspase Cascade3613.0BID, BIRC2, BIRC3, BAD, GZMB, ARHGDIB
27Viral myocarditis2012.9RAC1, RAC2, BID, FYN, CD28, CD86
28Autoimmune thyroid disease2012.9CD28, CD86, CD40LG, CD80, CD40, GZMB
29Apoptosis and survival Lymphotoxin-beta receptor signaling1012.9RELB, BIRC2, CHUK, BAX, JUN, IL2
30IL-10 Pathway3612.6PIK3R1, PIM1, MYC, BCL2L1, CD14, IL10
31DNA damage ATM/ATR regulation of G1/S checkpoint1012.6REL, RELB, NBN, MYC, BLM, CHEK2
32Cell cycle Cell cycle (generic schema)1012.6RB1, RBL2, CDK6, CDK2, CDC25C, CDC25B
33Ceramide Pathway3612.4PIK3R1, RAF1, BAD, ATF3, JUN, JUNB
34Hepatitis C2012.4PIK3CA, PIK3R1, PIK3CG, BRAF, RAF1, CHUK
35ATM Pathway3612.3BRCA1, RAD50, BID, CHEK2, ATM, MRE11A
36DR3 Signaling3612.2BID, BIRC2, BIRC3, CHUK, BAG4, APAF1
37Phospholipase-C Pathway3612.2KITLG, VEGFC, BMP6, RAF1, RAC1, RAC2
38NFAT in Immune Response3612.2PIK3R1, KITLG, VEGFC, BMP6, KDR, CHUK
39Cell cycle ESR1 regulation of G1/S transition1011.8RB1, RBL2, MYC, JUN, CDK6, CDKN1A
40GITR Pathway3611.8CHUK, IKBKB, CASP7, CASP10, CASP3, CASP4
41TGF-beta Signaling Pathways3711.7PIK3R1, PIK3CG, NCOR2, REL, RELB, BRAF
42Development Thrombopoietin-regulated cell processes1011.7PIK3CA, PIK3R1, BRAF, MYC, RAF1, RAC1
43Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response1011.7REL, RELB, MYD88, CHUK, JUN, CD14
44Development_VEGF signaling and activation4111.5PIK3CA, REL, RELB, SELE, BRCA1, VEGFA
45Apoptosis and survival_Role of CDK5 in neuronal death and survival4111.3PIK3CA, PIK3R1, RAF1, BCL2, BAD, BAX
46Development_VEGF signaling via VEGFR2 - generic cascades4111.3PIK3CA, PIK3R1, VEGFA, RAF1, RAC1, RASA1
47Development EPO-induced Jak-STAT pathway1011.2PIM1, MYC, RAF1, RASA1, BCL2, BCL2L1
48Non-small cell lung cancer2011.2PIK3CA, PIK3R1, PIK3CG, RB1, BRAF, RAF1
49Development_Angiopoietin - Tie2 signaling4111.2PIK3CA, PIK3R1, REL, RELB, CHUK, FOXO1
50Apoptosis and survival Role of CDK5 in neuronal death and survival1011.0BCL2, BAD, APAF1, CASP9, CYCS, NTRK1

Compounds for genes affiliated with Hodgkin's Lymphoma

about this section
Sources:
32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB
See all sources

Compounds related to hodgkin's lymphoma according to GeneDecks:

(show top 50)    (show all 441)
idCompoundScoreTop Affiliating Genes
1estrogen32 18.9PIK3R1, NCOR2, PCNA, SERPINB9, SET, BSG
2progesterone32 42 9 18 9 21.3PIK3CA, PIK3R1, NCOR2, PCNA, RB1, BSG
3camptothecin32 42 9 9 19.7PIK3CG, PCNA, RB1, NBN, BRCA1, MYC
4imatinib32 34 9 9 19.5PIK3CA, PIK3R1, PIK3CG, KITLG, SELL, BRAF
5wortmannin32 42 17.4PIK3CA, PIK3R1, PIK3CG, KITLG, VIM, BRAF
6rituximab32 34 9 9 19.1RAF1, BID, BIRC2, BIRC5, PAX5, BCL2
7adpribose32 15.6PIK3CA, PIK3CG, PCNA, RB1, BRCA1, BID
8threonine32 15.2PIM2, SH2D1A, NCF4, REL, RBL2, NBN
9neopterin32 15.0LGALS3BP, CHKB, LBR, B2M, CD79A, CD14
10carbon32 14.6CNR1, CNR2, PCNA, VDR, BCHE, LDLR
11mg 13232 42 14.9PIK3CG, NCOR2, PCNA, BRCA1, VDR, MYC
12pentoxifylline32 9 9 15.8SELL, BMP6, LBR, MPO, CD14, ITGA4
13n acetylcysteine32 13.7PCNA, SELE, RAF1, BIRC5, CLU, KDR
14betacarotene32 13.7PCNA, RB1, NAT2, LEP, MTHFR, CD79A
15retinoid32 13.7NCOR2, SELL, VIM, VDR, MYC, MYCN
16trastuzumab32 34 9 9 16.6PIK3CA, PIK3R1, PIK3CG, VEGFC, RAF1, BIRC5
17okadaic acid32 42 14.6PIK3CA, PIK3R1, RB1, VIM, MYC, MYB
18quercetin32 42 9 18 9 17.5PIK3CA, PIK3R1, PIK3CG, PIM1, SELE, RAF1
19thyroxine32 18 14.5PCNA, VDR, LEP, LEPR, CHKB, UGT1A1
20phorbol32 13.2NCF2, REL, SELL, MYC, MYB, RAF1
21sialic acid32 13.1SELL, SELPLG, CLU, BCR, LGALS1, CFH
22okt332 13.1SELE, BMP6, ZAP70, LCK, LBR, CD79A
23malondialdehyde32 12.9CHKB, LBR, MPO, GSR, GSTM1, GSTT1
24triptolide32 12.9VEGFA, BIRC3, PARP1, BCL2, BAX, JUN
25chloroquine32 34 9 9 15.5BRCA1, BMP6, RAF1, LDLR, B2M, CD79A
26pioglitazone32 9 9 14.5NCOR2, BSG, VEGFA, LEP, CFD, JUN
27egcg32 12.4PIK3CG, RAF1, BCL2L1, CHUK, UGT1A1, LDLR
28valproic acid32 34 9 18 9 16.4KITLG, MYCN, UGT1A1, UGT1A6, CFLAR, CDK4
29acetaminophen32 34 9 18 9 16.3PCNA, NAT2, MYC, BCL2L1, UGT1A1, UGT1A6
30dmso32 12.3KITLG, VIM, BMP6, BCL2A1, UGT1A6, CD36
31cyclophosphamide32 34 9 9 15.2BCL6, MVP, MS4A1, ITGA4, ITGB2, FLT3LG
32glycerol32 9 18 9 15.2PCNA, BRCA1, LEP, CHKB, CHUK, CD79A
33p0000132 12.1BRAF, VEGFC, BIRC5, MTHFR, S100A8, CDKN1B
34polymyxin b32 12.0SELE, LDLR, CD14, ITGB2, IL10, IL1A
35il-1232 12.0CD86, CD40LG, IL10, IL12B, IL13, IL15
36taxane32 11.9VEGFA, BIRC5, KDR, BCL2, MTOR, MTHFR
37sulindac sulfide32 11.8PCNA, BMP6, BCL2, BCL2L1, BAX, ATF3
38phenethyl isothiocyanate32 11.8MYC, BID, PARP1, BCL2, BCL2L1, BAX
39progestin32 11.7PIK3R1, VIM, VEGFA, KDR, CDK6, CDK4
40gf 109203x32 42 12.5PIK3CG, KITLG, VEGFA, RAF1, JUN, JAK2
41l-nmma32 11.5INSR, IL1RN, IGHE, CAT, GHRL, PPARG
42inositol32 11.4SH2D1A, KIR3DL1, BCR, LBR, CD79A, INPP5E
43cocaine32 9 9 13.4CNR1, SELE, VIM, BMP6, BCHE, LEP
44tpck32 11.2PIK3CG, PARP1, BCHE, BCL2L1, BAK1, JUN
45vanadate32 11.2LCK, FYN, JAK2, CDC25C, CDKN3, CDK1
46rotenone32 10.9PIK3CG, PARP1, BCL2, BCL2L1, BAD, GSR
47butyrate32 INFKLF4, NCF2, KITLG, PCNA, RB1, VIM
48arachidonic acid32 9 18 9 INFPIK3CA, NCF2, NCF4, CNR1, KITLG, VIM
49aspartate32 INFPIK3R1, CNR1, PCNA, VIM, BRAF, VDR
50formaldehyde32 18 INFPCNA, RB1, SELE, SELL, VIM, LGALS3

GO Terms for genes affiliated with Hodgkin's Lymphoma

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Sources:
12Gene Ontology
See all sources

Cellular components related to hodgkin's lymphoma according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563428.2PIM1, NCOR2, RELB, PCGF2, PCNA, RB1
2cytoplasmGO:00573726.7PIK3CG, PIM1, SH2D1A, KLHDC8B, NCF2, KITLG
3plasma membraneGO:00588626.5PIK3R1, PIK3CG, PIM1, PDCD1, PDCD1LG2, CNR1
4cytosolGO:00582924.4PIK3CA, PIK3R1, PIK3CG, NCF2, NCF4, REL
5integral to plasma membraneGO:00588720.9CNR1, CNR2, KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1
6extracellular regionGO:00557620.3PDCD1LG2, KITLG, SERPING1, VEGFA, VEGFC, CLU
7extracellular spaceGO:00561519.9KITLG, SELE, SERPINB9, VEGFA, VEGFC, BMP6
8nucleoplasmGO:00565417.2RFC1, NCOR2, REL, PCNA, RB1, RBBP7
9external side of plasma membraneGO:00989717.2SELL, KDR, LDLR, LAG3, B2M, CD28
10cell surfaceGO:00998613.2VEGFA, LGALS1, LDLR, CD36, CD14, CD59
11membrane raftGO:04512112.0SELE, BSG, BCL10, LCK, JAK2, CD79A

Biological processes related to hodgkin's lymphoma according to GeneDecks:

(show top 50)    (show all 59)
idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:00691520.7PIM1, PDCD1, NBN, VIM, BRCA1, BNIP2
2immune responseGO:00695520.2NCF4, PDCD1LG2, CNR2, KIR2DS5, KIR2DL1, KIR2DL3
3signal transductionGO:00716518.4PDCD1, KITLG, VEGFC, VDR, MYD88, RAF1
4innate immune responseGO:04508717.0PIK3CG, NCF2, SERPING1, MYD88, CLU, BCL10
5induction of apoptosisGO:00691716.3BNIP3, BIK, BCL10, BCL2L11, BCL2L13, BCLAF1
6cell proliferationGO:00828316.0PIM2, PIM1, KITLG, PCNA, RBBP7, NBN
7negative regulation of apoptotic processGO:04306615.7PIK3CG, PIM1, PCGF2, BRAF, VEGFA, MYC
8anti-apoptosisGO:00691615.5PIM2, PIK3CA, SERPINB9, BRAF, BNIP2, BNIP3
9inflammatory responseGO:00695415.4PIK3CG, CNR2, SELE, MYD88, BMP6, RAC1
10positive regulation of transcription from RNA polymerase II promoterGO:04594415.4KLF4, RB1, BRCA1, VEGFA, VDR, LMO2
11positive regulation of transcription, DNA-dependentGO:04589315.1PIM2, KLF4, REL, RB1, BRCA1, MYC
12positive regulation of cell proliferationGO:00828415.0NBN, VEGFA, VEGFC, MYC, RAC2, BIRC5
13positive regulation of apoptotic processGO:04306514.7CNR1, BID, CLU, BCL2L11, BCL6, BCLAF1
14cell surface receptor signaling pathwayGO:00716614.4BSG, MYD88, BIRC2, BIRC3, LEPR, BAG1
15positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312314.4PIM2, REL, MYD88, BIRC2, BIRC3, BCL10
16regulation of immune responseGO:05077614.2KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1, KIR2DS2, KIR2DS1
17response to drugGO:04249314.2NCF2, NBN, VEGFC, MYC, BCHE, BCL2
18virus-host interactionGO:01904813.9PIK3R1, RB1, VIM, BNIP3, RAN, BECN1
19induction of apoptosis by extracellular signalsGO:00862413.9VDR, RAC1, BCL2L11, BAD, BAK1, BAX
20blood coagulationGO:00759613.8PIK3CA, PIK3R1, PIK3CG, SELL, SELPLG, SERPING1
21response to hypoxiaGO:00166613.8VEGFA, BNIP3, RAF1, BCL2, LEP, ATM
22negative regulation of cell proliferationGO:00828513.7PIM2, KLF4, VDR, RAF1, BECN1, BCL6
23negative regulation of transcription, DNA-dependentGO:04589213.6KLF4, RB1, SET, BRCA1, VDR, MYB
24negative regulation of transcription from RNA polymerase II promoterGO:00012213.6KLF4, NCOR2, PCGF2, VDR, MYC, MYB
25positive regulation of NF-kappaB transcription factor activityGO:05109213.6MYD88, CLU, BCL10, CHUK, CD40, AR
26complement activation, classical pathwayGO:00695813.6SERPING1, CLU, CD55, CD46, MBL2, MASP2
27activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691913.5MYC, BCL2L10, BCL2L11, BCL2L13, LCK, BAD
28induction of apoptosis by intracellular signalsGO:00862913.3BNIP3, MYC, BID, CLU, BCL2, BCL2L1
29cytokine-mediated signaling pathwayGO:01922113.3MYD88, BAD, B2M, CEBPA, JAK2, CD44
30response to DNA damage stimulusGO:00697413.3BRCA1, MYC, RAD50, RASSF1, BLM, BCL2
31cellular response to mechanical stimulusGO:07126013.2BNIP3, MYD88, BCL10, BAD, BAK1, CD40
32regulation of apoptotic processGO:04298112.8BRCA1, RAF1, BIRC5, BCL2L14, BCL3, LGALS1
33activation of pro-apoptotic gene productsGO:00863312.7MYC, BID, BCL2, BCL2L11, BAD, BAK1
34organ regenerationGO:03110012.6LEF1, UGT1A1, LCP1, BAK1, CEBPA, CDKN1A
35agingGO:00756812.5NCF2, CNR1, VDR, BAK1, JUN, IL15
36response to ethanolGO:04547112.5CNR1, BCL2, BAK1, S100A8, FYN, CD27
37nerve growth factor receptor signaling pathwayGO:04801112.5PIK3CA, PIK3R1, BRAF, MYD88, RAF1, RAC1
38response to toxinGO:00963612.4BCL2, BAX, XPA, CDKN1A, CDK1, ASNS
39response to organic cyclic compoundGO:01407012.4NCF2, LEF1, UGT1A1, BAK1, MSH2, JUN
40positive regulation of B cell proliferationGO:03089012.3BCL2, BCL6, CDKN1A, CD40LG, CD40, CD38
41fibroblast growth factor receptor signaling pathwayGO:00854312.0PIK3CA, PIK3R1, BRAF, RAF1, CHUK, BAD
42platelet activationGO:03016812.0PIK3CA, PIK3R1, PIK3CG, SERPING1, VEGFA, VEGFC
43response to lipopolysaccharideGO:03249611.9NCF2, CNR1, CNR2, SELE, UGT1A1, S100A8
44positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.8KITLG, VEGFA, MTOR, JAK2, CD36, CD80
45phosphatidylinositol-mediated signalingGO:04801511.7PIK3CA, PIK3R1, PCNA, CHUK, BAD, MTOR
46positive regulation of angiogenesisGO:04576611.4VEGFA, KDR, CD34, MMP9, FLT1, FGF1
47T cell costimulationGO:03129511.2PIK3CA, PIK3R1, PDCD1, PDCD1LG2, RAC1, LCK
48response to estradiol stimulusGO:03235511.1VDR, BID, AURKA, MMP9, INSR, IL1B
49positive regulation of nitric oxide biosynthetic processGO:04542910.9JAK2, INS, INSR, IL1B, IFNG, ICAM1
50protein autophosphorylationGO:04677710.4PIM1, KDR, CHEK2, ZAP70, MTOR, AURKA

Molecular functions related to hodgkin's lymphoma according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551541.3RIPK1, POU2F1, POLI, CSF2, SOD3, SOD1
2protein homodimerization activityGO:04280316.0SOD1, STAT1, DPP4, TGFB1, TKT, TOP2A
3receptor bindingGO:00510214.4EPHX2, ADIPOQ, C3, C5, NPY, NPPB
4protein heterodimerization activityGO:04698214.3HIF1A, EGFR, LTC4S, CYBA, OTX2, TP53
5cytokine activityGO:00512514.2ADIPOQ, TNF, HMGB1, IFNG, IFNB1, IFNA2
6protein kinase bindingGO:01990113.7SYK, TP53, IKBKB, CCND1, CCND3, CCND2
7sequence-specific DNA binding transcription factor activityGO:00370013.4CREB1, NOTCH1, NFKB1, NFKB2, WT1, HIF1A
8identical protein bindingGO:04280213.0STAT6, TP53, TRADD, TRAF2, ESR1, AKT1
9transcription factor bindingGO:00813412.1AHR, HIF1A, NFKBIA, CTNNB1, SRF, TNFRSF10A
10tumor necrosis factor receptor bindingGO:00516411.6LTB, LTA, TNFSF8, TNFSF4, TNFSF13B, TNFSF13
11enzyme bindingGO:01989911.5BIRC7, BIRC5, RAC1, BRCA1, BCHE, HDAC10

Sources for Hodgkin's Lymphoma

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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