HL
MCID: HDG007
MIFTS: 93

Hodgkin's Lymphoma (HL) malady

Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories
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Summaries for Hodgkin's Lymphoma

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MedlinePlus:33 Hodgkin disease is a type of lymphoma. lymphoma is a cancer of a part of the immune system called the lymph system. the first sign of hodgkin disease is often an enlarged lymph node. the disease can spread to nearby lymph nodes. later it may spread to the lungs, liver, or bone marrow. the exact cause is unknown. hodgkin disease is rare. symptoms include painless swelling of the lymph nodes in the neck, armpits, or groin fever and chills night sweats weight loss loss of appetite itchy skin to diagnose hodgkin disease, doctors use a physical exam and history, blood tests, and a biopsy. treatment depends on how far the disease has spread. it often includes radiation therapy or chemotherapy. the earlier the disease is diagnosed, the more effective the treatment. in most cases, hodgkin disease can be cured. nih: national cancer institute

MalaCards based summary: Hodgkin's Lymphoma, also known as hodgkin lymphoma, is related to non-hodgkin lymphoma and chronic lymphocytic leukemia, and has symptoms including lymphadenopathy/polyadenopathies, immunodeficiency/increased susceptibility to infections/recurrent infections and lymphoma. An important gene associated with Hodgkin's Lymphoma is KLHDC8B (kelch domain containing 8B), and among its related pathways are Death Receptor Signalling and DNA damage ATM ATR regulation of G1 S checkpoint. The drugs cyclophosphamide and cisplatin and the compounds 7,12-dimethylbenz(a)anthracene and methylmethanesulfonate have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and lymph node, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Disease Ontology:8 A lymphoma that is marked by the presence of a type of cell called the reed-sternberg cell.

Wikipedia:65 Hodgkin lymphoma, also known as Hodgkin\'s lymphoma or Hodgkin\'s disease, is a type of lymphoma, which... more...

Descriptions from OMIM:46 236000,300221,400021

Aliases & Classifications for Hodgkin's Lymphoma

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 9diseasecard, 46OMIM, 62UMLS, 44Novoseek, 33MedlinePlus, 22GTR, 48Orphanet, 57SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 25ICD10
See all sources

Hodgkin's Lymphoma, Aliases & Descriptions:

Name: Hodgkin's Lymphoma 30 8 42
Hodgkin Lymphoma 8 9 42 46 62
Hodgkin Disease 8 42 44 33 62
Classical Hodgkin's Lymphoma 48 62
Classical Hodgkin Disease 48 62
Lymphoma, Hodgkin's 42 22
Hodgkins Lymphoma 8 10
Hodgkin's Sarcoma 8 62
 
Hodgkin's Disease of Lymph Nodes of Inguinal Region and/or Lower Limb 62
Hodgkin's Disease of Intrapelvic Lymph Nodes 62
Stage Ii Subdiaphragmatic Hodgkin Lymphoma 8
Stage I Subdiaphragmatic Hodgkin Lymphoma 8
Classical Hodgkin's Disease 48
Hodgkin Lymphoma, Classical 48
Hl 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
classical hodgkin's lymphoma:
Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Any age


Related Diseases for Hodgkin's Lymphoma

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Diseases related to Hodgkin's Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 403)
idRelated DiseaseScoreTop Affiliating Genes
1non-hodgkin lymphoma31.8CFLAR, NBN, TNFRSF8, PTPRC, PAX5, HPRT1
2chronic lymphocytic leukemia31.5TNFSF8, TNFRSF8, PAX5, BCL6
3mantle cell lymphoma31.5MDM2, BCL6
4anaplastic large cell lymphoma31.3TNFSF8, TNFRSF8, PTPRC, PAX5, BCL6
5familial non-hodgkin lymphoma31.1BRAF, CASP10
6myeloma31.0TNFRSF8, CFLAR, PAX5, BCL6, PTPRC
7sarcoma31.0BRAF, CFLAR, PTPRC, MDM2
8hairy cell leukemia31.0TNFSF8, BCL6, PTPRC
9central nervous system lymphoma31.0BCL6
10b-cell lymphomas30.9NBN, CFLAR, TNFRSF8, PTPRC, TIA1, PAX5
11lymphoblastic lymphoma30.9PTPRC, PAX5, BCL6
12ataxia telangiectasia30.9MDM2, NBN, HPRT1
13peripheral t-cell lymphoma30.9TNFRSF8, PAX5, PTPRC, TIA1, BCL6
14follicular lymphoma30.9PTPRC, PAX5, BCL6, REL
15acute lymphoblastic leukemia30.8HPRT1, PAX5, PTPRC, TNFSF8, NBN, BCL6
16leukemia30.8NBN, CFLAR, BCL6, CARD16, CASP10, HPRT1
17burkitt's lymphoma30.8PAX5, MDM2, CFLAR, TNFRSF8, BCL6
18angioimmunoblastic t-cell lymphoma30.8BCL6
19colorectal cancer30.6CFLAR, MDM2, HPRT1, BRAF, NBN
20breast cancer30.5TNFAIP3, CASP10, HPRT1, PTPRC, NBN, MDM2
21autoimmune lymphoproliferative syndrome30.5PTPRC, CASP10
22stomach cancer30.5NBN, CASP10, BRAF, CFLAR
23lung cancer30.3HPRT1, BRAF, NBN, CFLAR, MDM2
24melanoma30.0MDM2, PTPRC, CASP10, NBN, CFLAR, TIA1
25nodular lymphocyte predominant hodgkin lymphoma11.0
26hepatitis10.7
27diffuse large b-cell lymphoma10.6
28mediastinitis10.6
29hepatitis c10.5
30testicular lymphoma10.5BCL6
31hematopoietic stem cell transplantation10.5
32multiple myeloma10.5
33hemolytic anemia10.5
34autoimmune hemolytic anemia10.5
35hodgkin's lymphoma, nodular sclerosis10.5
36hodgkin's lymphoma, lymphocytic depletion10.5
37mixed cellularity classical hodgkin lymphoma10.5
38hepatitis b10.4
39neutropenia10.4
40progressive multifocal leukoencephalopathy10.4
41t-cell/histiocyte rich large b cell lymphoma10.4
42lymphocyte-rich classical hodgkin lymphoma10.4
43central nervous system lymphoma, primary10.4BCL6, PAX5
44composite lymphoma10.4
45lymphoblastic leukemia10.4
46reticulosarcoma10.4TIA1, BCL6, TNFRSF8
47lymphosarcoma10.4BCL6, TNFRSF8
48lymphomatoid papulosis10.4TIA1, TNFRSF8
49mycosis fungoides10.4
50cryoglobulinemia10.4

Graphical network of the top 20 diseases related to Hodgkin's Lymphoma:



Diseases related to hodgkin's lymphoma

Symptoms for Hodgkin's Lymphoma

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Symptoms by clinical synopsis from OMIM:

236000

Clinical features from OMIM:

236000,300221,400021

Symptoms:

48 (show all 23)
  • lymphadenopathy/polyadenopathies
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • lymphoma
  • asthenia/fatigue/weakness
  • hyperhidrosis/increased sweating
  • pruritus/itching
  • thoracic/chest pain
  • cough
  • anorexia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • cutaneous rash
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • hemoptysis
  • peripheral neuropathy
  • facial pain/cephalalgia/migraine
  • ataxia/incoordination/trouble of the equilibrium
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone pain
  • bone marrow failure/pancytopenia
  • neoplasms/tumors

HPO human phenotypes related to Hodgkin's Lymphoma:

(show all 42)
id Description Frequency HPO Source Accession
1 lymphoma hallmark (90%) HP:0002665
2 lymphadenopathy hallmark (90%) HP:0002716
3 abnormality of immune system physiology hallmark (90%) HP:0010978
4 lymphoma hallmark (90%) HP:0002665
5 lymphadenopathy hallmark (90%) HP:0002716
6 abnormality of immune system physiology hallmark (90%) HP:0010978
7 hyperhidrosis typical (50%) HP:0000975
8 pruritus typical (50%) HP:0000989
9 weight loss typical (50%) HP:0001824
10 anorexia typical (50%) HP:0002039
11 abnormality of temperature regulation typical (50%) HP:0004370
12 chest pain typical (50%) HP:0100749
13 hyperhidrosis typical (50%) HP:0000975
14 pruritus typical (50%) HP:0000989
15 weight loss typical (50%) HP:0001824
16 anorexia typical (50%) HP:0002039
17 abnormality of temperature regulation typical (50%) HP:0004370
18 chest pain typical (50%) HP:0100749
19 skin rash occasional (7.5%) HP:0000988
20 splenomegaly occasional (7.5%) HP:0001744
21 migraine occasional (7.5%) HP:0002076
22 respiratory insufficiency occasional (7.5%) HP:0002093
23 hemoptysis occasional (7.5%) HP:0002105
24 hepatomegaly occasional (7.5%) HP:0002240
25 incoordination occasional (7.5%) HP:0002311
26 bone pain occasional (7.5%) HP:0002653
27 osteolysis occasional (7.5%) HP:0002797
28 bone marrow hypocellularity occasional (7.5%) HP:0005528
29 peripheral neuropathy occasional (7.5%) HP:0009830
30 splenomegaly occasional (7.5%) HP:0001744
31 migraine occasional (7.5%) HP:0002076
32 respiratory insufficiency occasional (7.5%) HP:0002093
33 hemoptysis occasional (7.5%) HP:0002105
34 hepatomegaly occasional (7.5%) HP:0002240
35 incoordination occasional (7.5%) HP:0002311
36 bone pain occasional (7.5%) HP:0002653
37 bone marrow hypocellularity occasional (7.5%) HP:0005528
38 peripheral neuropathy occasional (7.5%) HP:0009830
39 autosomal recessive inheritance HP:0000007
40 impaired lymphocyte transformation with phytohemagglutinin HP:0003347
41 polyclonal elevation of igm HP:0003459
42 hodgkin lymphoma HP:0012189

Drugs & Therapeutics for Hodgkin's Lymphoma

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Genetic Tests for Hodgkin's Lymphoma

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Genetic tests related to Hodgkin's Lymphoma:

id Genetic test Affiliating Genes
1 Hodgkin Lymphoma22

Anatomical Context for Hodgkin's Lymphoma

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MalaCards organs/tissues related to Hodgkin's Lymphoma:

32
B cells, Bone, Lymph node, T cells, Bone marrow, Lung, Liver, Breast, Skin, Testes, Endothelial, Salivary gland, Prostate, Myeloid, Adrenal gland, Monocytes, Neutrophil, Thyroid, Testis, Nk cells, Spleen, Spinal cord, Small intestine, Colon, Kidney, Cervix, Pituitary, Thymus, Brain, Heart, Ovary, Tonsil, Tongue

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Hodgkin's Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Hodgkin's Lymphoma or affiliated genes

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Publications for Hodgkin's Lymphoma

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Articles related to Hodgkin's Lymphoma:

(show top 50)    (show all 1829)
idTitleAuthorsYear
1
Population Pharmacokinetics of Obinutuzumab (GA101) in Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin's Lymphoma and Exposure-Response in CLL. (25353187)
2014
2
Hodgkin's lymphoma coexisting with liver failure secondary to acute on chronic hepatitis B. (24303460)
2013
3
Survival and Prognostic Factors for AIDS and Non-AIDS Patients with Non-Hodgkin's Lymphoma in Bahia, Brazil: A Retrospective Cohort Study. (24288620)
2013
4
The effect of involved-field radiotherapy on survival in patients with early-stage Hodgkin's lymphoma after autologous stem cell transplantation. (22471651)
2012
5
Effects of microvascular density on primary pulmonary non-Hodgkin's lymphoma (PPL). (22875783)
2012
6
Primary extradural non-hodgkin's lymphoma. (23919074)
2012
7
Primary extranodal non-Hodgkin's lymphoma involving masseter and buccinator muscles. (22464613)
2012
8
Non-Hodgkin's lymphoma "masquerading" as Pott's disease in a 13-year old boy. (22174499)
2011
9
Personal use of hair dyes--increased risk of non-Hodgkin's lymphoma in Thailand. (22296389)
2011
10
Inhibition of Syk protein tyrosine kinase induces apoptosis and blocks proliferation in T-cell non-Hodgkin's lymphoma cell lines. (19776763)
2010
11
High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma. (18929412)
2009
12
Identification of L-plastin autoantibody in plasma of patients with non-Hodgkin's lymphoma using a proteomics-based analysis. (18275676)
2008
13
High expression of minichromosome maintenance protein 6 in classic Hodgkin's lymphoma points to a cell cycle arrest in G1 phase. (18759521)
2008
14
Immunoglobulin light chain gene translocations in non-Hodgkin's lymphoma as assessed by fluorescence in situ hybridisation. (18005388)
2008
15
Cervical radiculopathy secondary to Hodgkin's lymphoma. (17445629)
2007
16
Discovery of novel epigenetic markers in non-Hodgkin's lymphoma. (16774933)
2007
17
The impact of high-dose sodium selenite therapy on Bcl-2 expression in adult non-Hodgkin's lymphoma patients: correlation with response and survival. (17916949)
2007
18
Effect of granulocyte colony-stimulating factor on IL-12 p40 production during chemotherapy for B-cell lineage non-Hodgkin's lymphoma patients. (16930137)
2006
19
Relapse of high-grade non-Hodgkin's lymphoma after autologous stem cell transplantation: a case successfully treated with cyclophosphamide plus somatostatin, bromocriptine, melatonin, retinoids, and ACTH. (17122540)
2006
20
Haplotypic variation in MRE11, RAD50 and NBS1 and risk of non-Hodgkin's lymphoma. (17169801)
2006
21
Craniofacial fibrous dysplasia and hypophysial microadenoma with Hodgkin's lymphoma: unusual involution of an extensive case. (16860225)
2006
22
An elderly case of non-Hodgkin's lymphoma (NHL) with hypercalcemia]. (12708052)
2003
23
Stimulation of T-cell cytokine production and NK-cell function by IL-2, IFN-alpha and histamine treatment during remission of non-Hodgkin's lymphoma. (14502258)
2003
24
Association between SV40 and non-Hodgkin's lymphoma. (15202523)
2003
25
Re: "anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma subtypes and B-cell chronic lymphocytic leukemia: a prospective study". (12851233)
2003
26
Proliferation-dependent expression and phosphorylation of pRB in B cell non-Hodgkin's lymphomas: dependence on RB1 copy number. (12145697)
2002
27
Granulocyte colony-stimulating factor in induction treatment of children with non-Hodgkin's lymphoma: a randomized study of the French Society of Pediatric Oncology. (11786572)
2002
28
Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma. (11313970)
2001
29
A new serologic index for low-grade non-Hodgkin's lymphoma based on initial CA125 and LDH serum levels. (11142490)
2000
30
Cytokine replacement in patients with HIV-1 non-Hodgkin's lymphoma: the rationale for low-dose interleukin-2 therapy. (10685658)
2000
31
Non-Hodgkin's lymphoma presenting with gigantomastia in pregnancy. (10912428)
1999
32
Implication of HTLV-I infection, strongyloidiasis, and P53 overexpression in the development, response to treatment, and evolution of non-Hodgkin's lymphomas in an endemic area (Martinique, French West Indies). (10096585)
1999
33
The expression of CD44, PCNA, vWF: Ag in non-Hodgkin's lymphoma and its relationship with the grade of malignancy]. (11263339)
1998
34
Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas and is moderately increased by CD40 ligation. (9683298)
1998
35
Apoptosis and apoptosis-related gene products in primary non-Hodgkin's lymphoma of the central nervous system. (9705131)
1998
36
Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation. (9047392)
1997
37
Idiotype vaccines for non-Hodgkin's lymphoma induce polyclonal immune responses that cover mutated tumor idiotypes: comparison of different vaccine formulations. (9345055)
1997
38
Patients suffering from both Hodgkin's disease and non-Hodgkin's lymphoma: a clinico-pathological and immuno-histochemical population-based study of 32 patients. (9178801)
1997
39
Tumor-specific rearrangements of the immunoglobulin heavy-chain gene in B-cell non-Hodgkin's lymphoma detected by in situ hybridization. (8547654)
1996
40
The morphologic spectrum of non-Hodgkin's lymphomas with BCL1/cyclin D1 gene rearrangements. (8619427)
1996
41
Increase of mobilized CD34-positive peripheral blood progenitor cells in patients with Hodgkin's disease, non-Hodgkin's lymphoma, and cancer of the testis. (8733686)
1996
42
The relationship between the gene mutation of p53 and the protein expression of p53 and Ki-67 in non-Hodgkin's lymphomas. (10846560)
1996
43
Effects of interleukin-3 following chemotherapy of non-Hodgkin's lymphoma. A prospective, controlled phase I/II study. (7698300)
1995
44
Granulocyte colony-stimulating factor following peripheral-blood progenitor-cell transplant in non-Hodgkin's lymphoma. (7535843)
1995
45
CD44 variant isoforms in non-Hodgkin's lymphoma: a new independent prognostic factor. (7537983)
1995
46
High-dose CHOP as initial therapy for patients with poor-prognosis aggressive non-Hodgkin's lymphoma: a dose-finding pilot study. (8523055)
1995
47
Questions about the role of granulocyte-macrophage colony-stimulating factor as adjunct to non-Hodgkin's lymphoma chemotherapy. (7980802)
1994
48
Immunohistochemical detection of p53 and bcl-2 proteins in non-Hodgkin's lymphoma. (8436340)
1993
49
Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin's lymphoma: a randomized controlled trial. (1381626)
1992
50
Sequential bcl-2 and c-myc oncogene rearrangements associated with the clinical transformation of non-Hodgkin's lymphoma. (2509518)
1989

Variations for Hodgkin's Lymphoma

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Clinvar genetic disease variations for Hodgkin's Lymphoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1KLHDC8BNM_173546.2(KLHDC8B): c.-158C> Tsingle nucleotide variantPathogenicrs387906223GRCh37Chr 3, 49209095: 49209095

Expression for genes affiliated with Hodgkin's Lymphoma

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Expression patterns in normal tissues for genes affiliated with Hodgkin's Lymphoma

Search GEO for disease gene expression data for Hodgkin's Lymphoma.

Pathways for genes affiliated with Hodgkin's Lymphoma

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Pathways related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1CFLAR, CASP10
210.0NBN, REL, MDM2
3
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
10.0MDM2, CASP10, CFLAR
4
Show member pathways
9.9REL, BRAF, TNFAIP3
5
Show member pathways
9.9TNFSF8, TNFRSF8, CASP10
69.9CFLAR, TNFAIP3, CASP10
7
Show member pathways
9.9CFLAR, TNFAIP3, CASP10
89.9CASP10, TNFAIP3, CFLAR
99.9MDM2, CASP10, BCL6
10
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.9MDM2, BCL6, BRAF
11
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.9PDCD1, REL, PTPRC
12
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.9TNFSF8, TNFRSF8, REL
139.8BCL6, PAX5, PTPRC
14
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
9.8MDM2, CASP10, REL, CFLAR
15
Show member pathways
9.7TNFSF8, TNFRSF8, TNFAIP3, CASP10
169.7MDM2, BCL6, REL, PAX5
179.7BCL6, REL, BRAF, PTPRC
18
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.7PTPRC, BRAF, REL, BCL6
19
Show member pathways
9.6CFLAR, TNFSF8, TNFRSF8, BRAF, CASP10
20
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.5CASP10, REL, PTPRC, TNFAIP3, CFLAR
21
Show member pathways
Alternative NF-kappaB pathway37
9.5CFLAR, TNFRSF8, TNFAIP3, REL, CASP10
22
Show member pathways
9.4CFLAR, TNFSF8, TNFRSF8, BRAF, CASP10, MDM2

Compounds for genes affiliated with Hodgkin's Lymphoma

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Compounds related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
17,12-dimethylbenz(a)anthracene4410.4MDM2, REL
2methylmethanesulfonate4410.4MDM2, HPRT1, NBN
3bpde4410.3MDM2, HPRT1
4mitomycin c4410.3MDM2, HPRT1, NBN
5geldanamycin44 50 61 1113.3CFLAR, BRAF, MDM2
6p0024410.3CFLAR, BRAF, MDM2
7rituximab44 50 1112.2BCL6, PAX5, CFLAR
8dutp4410.2CFLAR, CARD16, MDM2
9adriamycin4410.2MDM2, HPRT1, CFLAR
10adenine44 24 1112.2TIA1, BRAF, HPRT1
11paclitaxel44 50 1112.2CFLAR, BRAF, CASP10, MDM2
12o6-methylguanine4410.2HPRT1, BRAF
13rapamycin4410.2MDM2, BRAF, NBN, CFLAR
14vincristine44 50 1112.2MDM2, BCL6, CFLAR
15imatinib44 50 1112.1MDM2, BCL6, BRAF, CFLAR
16irinotecan44 50 1112.1CFLAR, BRAF, CARD16, MDM2
17camptothecin44 61 1112.1CFLAR, NBN, CARD16, MDM2
18[alcl]4410.1TNFRSF8, PTPRC, TIA1, PAX5
19cisplatin44 50 61 1113.0CFLAR, BRAF, HPRT1, CASP10, MDM2
20doxorubicin44 50 1112.0CFLAR, NBN, BCL6, MDM2
21cyclophosphamide44 50 1112.0HPRT1, BCL6, MDM2
22oligonucleotide4410.0CFLAR, BRAF, PAX5, REL, MDM2
235-aza-2deoxycytidine449.9CFLAR, HPRT1, MDM2
24testosterone44 61 24 1112.9MDM2, HPRT1, PAX5, PTPRC, CFLAR
25etoposide44 50 61 1112.9CFLAR, NBN, HPRT1, CARD16, MDM2
26phosphatidylinositol449.9CFLAR, NBN, PTPRC, BRAF, MDM2
27h2o2449.9CFLAR, TNFAIP3, PTPRC, HPRT1, MDM2
28cyclosporin a44 28 6111.9CFLAR, TNFRSF8, PTPRC, REL
29thymidine44 2410.8CFLAR, TNFRSF8, HPRT1, MDM2
30arsenite44 2410.8MDM2, TIA1, CFLAR
31cycloheximide449.8CFLAR, TNFAIP3, PTPRC, BCL6, MDM2
32nitric oxide44 24 1111.7CFLAR, TNFAIP3, REL, CARD16, MDM2
33valine449.7MDM2, HPRT1, BRAF
34zinc44 2410.6TNFRSF8, TNFAIP3, PAX5, REL, BCL6, MDM2
35estrogen449.6PTPRC, BRAF, REL, BCL6, MDM2
36cysteine449.5CFLAR, PTPRC, REL, HPRT1, CASP10, CARD16
37paraffin449.5TNFRSF8, PTPRC, TIA1, BRAF, PAX5, BCL6
38threonine449.4CFLAR, NBN, TNFRSF8, PTPRC, TIA1, BRAF
39calcium44 50 24 1112.3CFLAR, TNFRSF8, PTPRC, BRAF, PAX5, REL
40tyrosine448.8CFLAR, TNFRSF8, PTPRC, BRAF, PAX5, REL
41serine448.4MDM2, CFLAR, NBN, TNFRSF8, PTPRC, TIA1

GO Terms for genes affiliated with Hodgkin's Lymphoma

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Cellular components related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.1BCL6, NBN
2CD95 death-inducing signaling complexGO:03126510.0CASP10, CFLAR
3ripoptosomeGO:0973429.8CASP10, CFLAR

Biological processes related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of I-kappaB kinase/NF-kappaB signalingGO:04312310.0CASP10, REL, CFLAR
2regulation of germinal center formationGO:0026349.9TNFAIP3, BCL6
3negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.8TNFAIP3, CFLAR
4apoptotic processGO:0069159.4PDCD1, CASP10, TIA1, TNFAIP3, TNFSF8, CFLAR

Molecular functions related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1death effector domain bindingGO:03587710.1CASP10, CFLAR
2protein bindingGO:0055157.7MDM2, CFLAR, NBN, TNFAIP3, PTPRC, FCRL4

Products for genes affiliated with Hodgkin's Lymphoma

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  • Antibodies
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Sources for Hodgkin's Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet