HL
MCID: HDG007
MIFTS: 91

Hodgkin's Lymphoma (HL) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Hodgkin's Lymphoma

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Hodgkin disease is a type of lymphoma. lymphoma is a cancer of a part of the immune system called the lymph system. the first sign of hodgkin disease is often an enlarged lymph node. the disease can spread to nearby lymph nodes. later it may spread to the lungs, liver, or bone marrow. the exact cause is unknown. hodgkin disease is rare. symptoms include painless swelling of the lymph nodes in the neck, armpits, or groin fever and chills night sweats weight loss loss of appetite itchy skin to diagnose hodgkin disease, doctors use a physical exam and history, blood tests, and a biopsy. treatment depends on how far the disease has spread. it often includes radiation therapy or chemotherapy. the earlier the disease is diagnosed, the more effective the treatment. in most cases, hodgkin disease can be cured. nih: national cancer institute

MalaCards: Hodgkin's Lymphoma, also known as hodgkin disease, is related to non-hodgkin lymphoma and leukemia, and has symptoms including respiratory distress/dyspnea/respiratory failure/lung volume reduction, immunodeficiency/increased susceptibility to infections/recurrent infections and asthenia/fatigue/weakness. An important gene associated with Hodgkin's Lymphoma is KLHDC8B (kelch domain containing 8B), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The drugs carmustine and chlorambucil and the compounds tyrosine and paraffin have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and lymph node, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A lymphoma that is marked by the presence of a type of cell called the reed-sternberg cell.

Wikipedia:63 Hodgkin lymphoma, also known as Hodgkin\'s lymphoma and Hodgkin\'s disease, is a type of lymphoma, which... more...

Description from OMIM:46 236000,300221,400021

Aliases & Classifications for Hodgkin's Lymphoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 30LifeMap Discovery™, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 9diseasecard, 46OMIM, 22GTR, 48Orphanet, 39NCIt, 27ICD9CM, 56SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
classical hodgkin's lymphoma:
Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

hodgkin's lymphoma 8 42 30
hodgkin disease 8 42 44 33 60
hodgkin lymphoma 9 42 46
classical hodgkin's lymphoma 48 60
hodgkin lymphoma, classical 48 46
lymphoma, hodgkin's 42 22
hodgkins lymphoma 8 10
hodgkin's disease of lymph nodes of inguinal region and/or lower limb 60
hodgkin's disease of intrapelvic lymph nodes 60
stage ii subdiaphragmatic hodgkin lymphoma 8
stage i subdiaphragmatic hodgkin lymphoma 8
classical hodgkin's disease 48
classical hodgkin disease 48
hodgkin's sarcoma 8
hl 8


Related Diseases for Hodgkin's Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hodgkin's Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 363)
idRelated DiseaseScoreTop Affiliating Genes
1non-hodgkin lymphoma32.2NBN, PAX5, MS4A1, CFLAR, FSCN1, MDM2
2leukemia31.2CARD16, MDM2, LTA, REL, CFLAR, PAX5
3chronic lymphocytic leukemia31.0CASP10, MDM2, LTA, REL, CFLAR, MS4A1
4hepatitis30.9LTA
5anaplastic large cell lymphoma30.9BCL6, PAX5, FSCN1, TNFSF8
6mantle cell lymphoma30.8BCL6, MDM2
7acute leukemia30.7PAX5
8hepatitis c30.7PAX5
9myeloma30.7LTA, CFLAR, PAX5, BCL6
10sarcoma30.6BRAF, MDM2, FSCN1, CFLAR
11histiocytosis30.4FSCN1
12central nervous system lymphoma30.4BCL6
13burkitt's lymphoma30.4CFLAR, PAX5, BCL6
14breast cancer30.3BRAF, CASP10, MDM2, REL, FSCN1, CFLAR
15adenocarcinoma30.3BRAF, CARD16, MDM2, FSCN1, CFLAR
16ataxia telangiectasia30.3NBN, MDM2
17melanoma30.2BRAF, CASP10, PDCD1, MDM2, FSCN1, CFLAR
18colorectal cancer30.2BRAF, MDM2, FSCN1, CFLAR, NBN
19arthritis30.1LTA, CFLAR
20familial non-hodgkin lymphoma30.1CASP10, BRAF
21myeloid leukemia30.1LTA
22adenoma30.0FSCN1, TNFSF8, BRAF
23stomach cancer29.9BRAF, CASP10, LTA, FSCN1, CFLAR
24bladder carcinoma29.9MDM2, LTA, CFLAR, PAX5
25lymphoma, diffuse large cell29.9MS4A1, PAX5, BCL6
26lymphoblastic lymphoma29.9BCL6, PAX5, MS4A1
27thyroid cancer29.9BRAF, CFLAR
28lung cancer29.9BRAF, MDM2, FSCN1, CFLAR, NBN
29systemic lupus erythematosus29.8PDCD1
30diffuse large b-cell lymphoma10.7
31adult lymphoma10.6
32mediastinitis10.6
33bone lymphoma10.5
34pediatric lymphoma10.5
35hepatitis b10.5
36composite lymphoma10.5
37hepatitis a10.5
38multiple myeloma10.5
39autoimmune hemolytic anemia10.4
40hemolytic anemia10.4
41breast lymphoma10.4
42hodgkin's lymphoma, nodular sclerosis10.4
43hodgkin's lymphoma, lymphocytic depletion10.4
44neutropenia10.4
45nodular lymphocyte predominant hodgkin lymphoma10.4
46ovarian lymphoma10.3
47gray zone lymphoma10.3
48lymphoblastic leukemia10.3
49mixed cellularity classical hodgkin lymphoma10.3
50gastric lymphoma10.3

Graphical network of the top 20 diseases related to Hodgkin's Lymphoma:



Diseases related to hodgkin's lymphoma

Clinical Features for Hodgkin's Lymphoma

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

236000,300221,400021

Clinical synopsis from OMIM:

236000

Symptoms:

48 (show all 23)
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • asthenia/fatigue/weakness
  • splenomegaly
  • hyperhidrosis/increased sweating
  • hepatomegaly/liver enlargement (excluding storage disease)
  • ataxia/incoordination/trouble of the equilibrium
  • fever/chilling
  • cutaneous rash
  • pruritus/itching
  • bone pain
  • bone marrow failure/pancytopenia
  • lymphoma
  • neoplasms/tumors
  • anorexia
  • facial pain/cephalalgia/migraine
  • osteolysis/osteoclasia/bone destruction/erosions
  • cough
  • lymphadenopathy/polyadenopathies
  • thoracic/chest pain
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • peripheral neuropathy
  • hemoptysis

Drugs & Therapeutics for Hodgkin's Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Genetic Tests for Hodgkin's Lymphoma

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Sources:
22GTR
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Genetic tests related to Hodgkin's Lymphoma:

id Genetic test Affiliating Genes
1 Hodgkin Lymphoma22

Anatomical Context for Hodgkin's Lymphoma

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Hodgkin's Lymphoma:

32
B cells, Bone, Lymph node, T cells, Bone marrow, Lung, Liver, Breast, Skin, Testes, Thyroid, Endothelial, Myeloid, Salivary gland, Prostate, Adrenal gland, Monocytes, Testis, Small intestine, Spleen, Nk cells, Colon, Thymus, Pituitary, Kidney, Spinal cord, Ovary, Brain, Tonsil, Heart, Cervix

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Hodgkin's Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Hodgkin's Lymphoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Hodgkin's Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.6PDCD1, NBN, PAX5, MS4A1, CFLAR, FSCN1
2MP:000539712.2PDCD1, MDM2, RHOH, LTA, BCL6, REL
3MP:000538412.2FSCN1, BCL6, NBN, PAX5, MS4A1, CFLAR
4MP:000537011.5PDCD1, MDM2, LTA, REL, BCL6, BRAF

Publications for Hodgkin's Lymphoma

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Sources:
50PubMed
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Articles related to Hodgkin's Lymphoma:

(show top 50)    (show all 1916)
idTitleAuthorsYear
1
Distribution of plasma fatty acids is associated with response to chemotherapy in non-Hodgkin's lymphoma patients. (24085546)
2013
2
Radiation Therapy for Early Stage Unfavourable Hodgkin's Lymphoma: Is Dose Reduction Feasible? (24354681)
2013
3
Risk, characteristics, and prognosis of breast cancer after Hodgkin's lymphoma. (22588325)
2012
4
The role of hematopoietic stem cell transplantation in the treatment of relapsed/refractory Hodgkin's lymphoma. (23079783)
2012
5
Histone deacetylase inhibition restores cisplatin sensitivity of Hodgkin's lymphoma cells. (22424710)
2012
6
Emerging Pharmacotherapy for Relapsed or Refractory Hodgkin's Lymphoma: Focus on Brentuximab Vedotin. (22253553)
2012
7
Endobronchial metastases of fibrosarcoma and non-Hodgkin's lymphoma. (22827792)
2012
8
B cell non-Hodgkin's lymphoma: experience from a tertiary care cancer center. (22584851)
2012
9
Central obesity predicts non-Hodgkin's lymphoma mortality and overall obesity predicts leukemia mortality in adult Taiwanese. (22081617)
2011
10
Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. (20415600)
2010
11
Bendamustine: a review of its use in the management of indolent non-Hodgkin's lymphoma and mantle cell lymphoma. (20731477)
2010
12
Anemia in Hodgkin's lymphoma: the role of interleukin-6 and hepcidin. (20406921)
2010
13
Serum soluble interleukin-2 receptor, beta2-microglobulin, lactate dehydrogenase and erythrocyte sedimentation rate in children with Hodgkin's lymphoma. (19874554)
2009
14
Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity. (19671844)
2009
15
Plerixafor: in patients with non-Hodgkin's lymphoma or multiple myeloma. (19275275)
2009
16
The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARC. (19591376)
2009
17
Identification of L-plastin autoantibody in plasma of patients with non-Hodgkin's lymphoma using a proteomics-based analysis. (18275676)
2008
18
Non-Hodgkin's lymphoma in a woman with adult-onset Still's disease: a case report. (18325097)
2008
19
P-glycoprotein expression in non-Hodgkin's lymphomas of human immunodeficiency virus infected patients. (17157997)
2007
20
Combined effects of histone deacetylase inhibitor and rituximab on non-Hodgkin's B-lymphoma cells apoptosis. (17681667)
2007
21
A phase 2 study of rituximab in combination with recombinant interleukin-2 for rituximab-refractory indolent non-Hodgkin's lymphoma. (17145827)
2006
22
Dendritic cells are significantly reduced in non-Hodgkin's lymphoma and express less CCR7 and CD62L. (16690519)
2006
23
The prognostic value of the expression of Bcl-2, p53 and LMP-1 in patients with Hodgkin's lymphoma. (16109607)
2005
24
Combination chemotherapy with adriamycin, cyclophosphamide, vincristine, methotrexate, etoposide and dexamethasone (ACOMED) followed by involved field radiotherapy induces high remission rates and durable long-term survival in patients with aggressive malignant non-Hodgkin's lymphomas: long-term follow-up of a pilot study. (16353313)
2005
25
Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. (14749477)
2004
26
The p73 locus is commonly deleted in non-Hodgkin's lymphomas. (15475076)
2004
27
Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese. (15291355)
2004
28
Expression of anaplastic lymphoma kinase in non-Hodgkin's lymphomas and other malignant neoplasms. Biological, diagnostic, and clinical implications. (14569815)
2002
29
Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma. (11313970)
2001
30
The expression and clinical significance of proliferative antigen Ki-67 and apoptosis-antagonizing antigen Bcl-2 in non-Hodgkin's lymphoma]. (11798613)
2001
31
Agricultural risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma. (11679800)
2001
32
Clonal deleterious mutations in the IkappaB alpha gene in the malignant cells in Hodgkin's lymphoma. (10637284)
2000
33
Expression of genes coding for the tumor necrosis factor and lymphotoxin ligand-receptor system in non-Hodgkin's lymphomas. (11092613)
2000
34
High-dose chemotherapy with BUCY or BEAC and unpurged peripheral blood stem cell infusion in patients with low-grade non-Hodgkin's lymphoma. (9509973)
1998
35
Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation. (9047392)
1997
36
Cytotoxic cell antigen expression in anaplastic large cell lymphomas of T- and null-cell type and Hodgkin's disease: evidence for distinct cellular origin. (9028330)
1997
37
The in vivo effects of interleukin-3 on histamine levels in non-Hodgkin's lymphoma patients. (9225366)
1997
38
Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis. (9121481)
1997
39
A phase II multicenter trial of high-dose sequential chemotherapy and peripheral blood stem cell transplantation as initial therapy for patients with high-risk non-Hodgkin's lymphoma. (9360783)
1997
40
Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin's lymphomas. Functional studies in a cell line (Granta 519). (9001420)
1997
41
Staging of non-Hodgkin's gastric lymphoma with endosonography-guided fine-needle aspiration biopsy and flow cytometry. (8979069)
1996
42
Expression of bcl-2 oncogene product in primary non-Hodgkin's malignant lymphoma of the oral cavity. (8685041)
1996
43
Efficacy of delayed granulocyte colony-stimulating factor after full dose CHOP therapy in non-Hodgkin's lymphoma: a pilot study for a leukocyte count oriented regimen. (8750630)
1995
44
A phase II trial of human recombinant interleukin-2 administered as a 4-day continuous infusion for children with refractory neuroblastoma, non-Hodgkin's lymphoma, sarcoma, renal cell carcinoma, and malignant melanoma. A Childrens Cancer Group study. (7773948)
1995
45
Cyclin D1 overexpression in non-Hodgkin's lymphoma with chromosome 11 bcl-1 rearrangement. (8172823)
1994
46
Differentiation between residual cancer and thymic hyperplasia in malignant non-Hodgkin's lymphoma with somatostatin receptor scintigraphy. (8137590)
1994
47
Null-cell non-Hodgkin's lymphoma presenting with a mass in the chest wall after tuberculous pyothorax]. (8295330)
1993
48
Deficiency of complement decay-accelerating factor (DAF, CD55) in non-Hodgkin's lymphoma. (1722775)
1991
49
Correlation of transferrin receptor expression with histologic grade and immunophenotype in chronic lymphocytic leukemia and non-Hodgkin's lymphoma. (2187855)
1990
50
Acute T-cell leukemia/lymphoma mimicking Hodgkin's disease with secondary HTLV I seroconversion. (2208004)
1990

Genetic Variations for Hodgkin's Lymphoma

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Expression for genes affiliated with Hodgkin's Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hodgkin's Lymphoma

Search GEO for disease gene expression data for Hodgkin's Lymphoma.

Pathways for genes affiliated with Hodgkin's Lymphoma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5CFLAR, LTA, MDM2, TNFSF8, CASP10, BRAF
2
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11.3BRAF, CASP10, TNFSF8, LTA, CFLAR
3
Hide members
11.3BRAF, CASP10, MDM2, LTA, CFLAR
4
Hide members
11.1CFLAR, LTA, MDM2, CASP10
511.1MDM2, REL, PAX5, BCL6
6
Hide members
11.0REL, LTA, CASP10
7
Hide members
11.0REL, LTA, CASP10
8
Hide members
11.0REL, LTA, BRAF
911.0CASP10, LTA, CFLAR
10
Hide members
11.0CFLAR, LTA, CASP10
1111.0MDM2, REL, NBN

Compounds for genes affiliated with Hodgkin's Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.7MDM2, PDCD1, CARD16, BRAF, RHOH, LTA
2paraffin4412.0BRAF, MDM2, LTA, FSCN1, MS4A1, PAX5
3threonine4412.0BRAF, MDM2, LTA, REL, FSCN1, CFLAR
4calcium44 49 11 2414.8BRAF, MDM2, LTA, REL, FSCN1, CFLAR
5oligonucleotide4411.8BRAF, MDM2, LTA, REL, CFLAR, PAX5
6retinoic acid44 2412.7BRAF, LTA, REL, FSCN1, CFLAR, BCL6
7serine4411.7NBN, CFLAR, FSCN1, LTA, CASP10
8rituximab44 49 1113.5CFLAR, MS4A1, PAX5, BCL6
9irinotecan44 49 1113.5CFLAR, MDM2, CARD16, BRAF
10camptothecin44 59 1113.5CARD16, MDM2, CFLAR, NBN
11imatinib44 49 1113.4BCL6, CFLAR, MDM2, BRAF
12etoposide44 49 59 1114.4NBN, CFLAR, MDM2, CARD16
1312-o-tetradecanoylphorbol 13-acetate4411.4BRAF, LTA, FSCN1, BCL6
14rapamycin4411.3NBN, CFLAR, MDM2, BRAF
15dutp4411.3CARD16, MDM2, CFLAR
16doxorubicin44 49 1113.3BCL6, NBN, CFLAR, MDM2
17paclitaxel44 49 1113.2CFLAR, MDM2, BRAF
18geldanamycin44 49 59 1114.2BRAF, MDM2, CFLAR
19estradiol44 11 2413.1PAX5, CFLAR, LTA, MDM2
20vincristine44 49 1113.1MDM2, CFLAR, BCL6
21actinomycin d4411.0CASP10, MDM2, LTA, CFLAR
22p0024411.0BRAF, MDM2, CFLAR
237,12-dimethylbenz(a)anthracene4410.5REL, MDM2

GO Terms for genes affiliated with Hodgkin's Lymphoma

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Sources:
16Gene Ontology
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Cellular components related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.8BCL6, NBN

Biological processes related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:00691511.2NBN, CFLAR, LTA, TNFSF8, PDCD1, CASP10
2humoral immune responseGO:00695911.0PAX5, LTA, PDCD1

Molecular functions related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase activityGO:00419711.0CFLAR, CARD16, CASP10

Products for genes affiliated with Hodgkin's Lymphoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hodgkin's Lymphoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet