HL
MCID: HDG007
MIFTS: 91

Hodgkin's Lymphoma (HL) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Hodgkin's Lymphoma

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Hodgkin disease is a type of lymphoma. lymphoma is a cancer of a part of the immune system called the lymph system. the first sign of hodgkin disease is often an enlarged lymph node. the disease can spread to nearby lymph nodes. later it may spread to the lungs, liver, or bone marrow. the exact cause is unknown. hodgkin disease is rare. symptoms include painless swelling of the lymph nodes in the neck, armpits, or groin fever and chills night sweats weight loss loss of appetite itchy skin to diagnose hodgkin disease, doctors use a physical exam and history, blood tests, and a biopsy. treatment depends on how far the disease has spread. it often includes radiation therapy or chemotherapy. the earlier the disease is diagnosed, the more effective the treatment. in most cases, hodgkin disease can be cured. nih: national cancer institute

MalaCards: Hodgkin's Lymphoma, also known as hodgkin disease, is related to non-hodgkin lymphoma and leukemia, and has symptoms including cough, pruritus/itching and thoracic/chest pain. An important gene associated with Hodgkin's Lymphoma is KLHDC8B (kelch domain containing 8B), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The drugs carmustine and chlorambucil and the compounds tyrosine and paraffin have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and lymph node, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A lymphoma that is marked by the presence of a type of cell called the reed-sternberg cell.

Wikipedia:63 Hodgkin lymphoma, also known as Hodgkin\'s lymphoma and Hodgkin\'s disease, is a type of lymphoma, which... more...

Description from OMIM:46 236000,300221,400021

Aliases & Classifications for Hodgkin's Lymphoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 30LifeMap Discovery™, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 9diseasecard, 46OMIM, 22GTR, 48Orphanet, 39NCIt, 27ICD9CM, 56SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
classical hodgkin's lymphoma:
Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

hodgkin's lymphoma 8 42 30
hodgkin disease 8 42 44 33 60
hodgkin lymphoma 9 42 46
classical hodgkin's lymphoma 48 60
hodgkin lymphoma, classical 48 46
lymphoma, hodgkin's 42 22
hodgkins lymphoma 8 10
hodgkin's disease of lymph nodes of inguinal region and/or lower limb 60
hodgkin's disease of intrapelvic lymph nodes 60
stage ii subdiaphragmatic hodgkin lymphoma 8
stage i subdiaphragmatic hodgkin lymphoma 8
classical hodgkin's disease 48
classical hodgkin disease 48
hodgkin's sarcoma 8
hl 8


Related Diseases for Hodgkin's Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hodgkin's Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 363)
idRelated DiseaseScoreTop Affiliating Genes
1non-hodgkin lymphoma32.2NBN, PAX5, MS4A1, CFLAR, FSCN1, MDM2
2leukemia31.2CARD16, MDM2, LTA, REL, CFLAR, PAX5
3chronic lymphocytic leukemia31.0CASP10, MDM2, LTA, REL, CFLAR, MS4A1
4hepatitis30.9LTA
5anaplastic large cell lymphoma30.9BCL6, PAX5, FSCN1, TNFSF8
6mantle cell lymphoma30.8BCL6, MDM2
7acute leukemia30.7PAX5
8hepatitis c30.7PAX5
9myeloma30.7LTA, CFLAR, PAX5, BCL6
10sarcoma30.6BRAF, MDM2, FSCN1, CFLAR
11histiocytosis30.4FSCN1
12central nervous system lymphoma30.4BCL6
13burkitt's lymphoma30.4CFLAR, PAX5, BCL6
14breast cancer30.3BRAF, CASP10, MDM2, REL, FSCN1, CFLAR
15adenocarcinoma30.3BRAF, CARD16, MDM2, FSCN1, CFLAR
16ataxia telangiectasia30.3NBN, MDM2
17melanoma30.2BRAF, CASP10, PDCD1, MDM2, FSCN1, CFLAR
18colorectal cancer30.2BRAF, MDM2, FSCN1, CFLAR, NBN
19arthritis30.1LTA, CFLAR
20familial non-hodgkin lymphoma30.1CASP10, BRAF
21myeloid leukemia30.1LTA
22adenoma30.0FSCN1, TNFSF8, BRAF
23stomach cancer29.9BRAF, CASP10, LTA, FSCN1, CFLAR
24bladder carcinoma29.9MDM2, LTA, CFLAR, PAX5
25lymphoma, diffuse large cell29.9MS4A1, PAX5, BCL6
26lymphoblastic lymphoma29.9BCL6, PAX5, MS4A1
27thyroid cancer29.9BRAF, CFLAR
28lung cancer29.9BRAF, MDM2, FSCN1, CFLAR, NBN
29systemic lupus erythematosus29.8PDCD1
30diffuse large b-cell lymphoma10.7
31adult lymphoma10.6
32mediastinitis10.6
33bone lymphoma10.5
34pediatric lymphoma10.5
35hepatitis b10.5
36composite lymphoma10.5
37hepatitis a10.5
38multiple myeloma10.5
39autoimmune hemolytic anemia10.4
40hemolytic anemia10.4
41breast lymphoma10.4
42hodgkin's lymphoma, nodular sclerosis10.4
43hodgkin's lymphoma, lymphocytic depletion10.4
44neutropenia10.4
45nodular lymphocyte predominant hodgkin lymphoma10.4
46ovarian lymphoma10.3
47gray zone lymphoma10.3
48lymphoblastic leukemia10.3
49mixed cellularity classical hodgkin lymphoma10.3
50gastric lymphoma10.3

Graphical network of the top 20 diseases related to Hodgkin's Lymphoma:



Diseases related to hodgkin's lymphoma

Clinical Features for Hodgkin's Lymphoma

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

236000,300221,400021

Clinical synopsis from OMIM:

236000

Symptoms:

48 (show all 23)
  • cough
  • pruritus/itching
  • thoracic/chest pain
  • hyperhidrosis/increased sweating
  • asthenia/fatigue/weakness
  • lymphoma
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • lymphadenopathy/polyadenopathies
  • anorexia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • bone pain
  • osteolysis/osteoclasia/bone destruction/erosions
  • ataxia/incoordination/trouble of the equilibrium
  • facial pain/cephalalgia/migraine
  • peripheral neuropathy
  • bone marrow failure/pancytopenia
  • hemoptysis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • splenomegaly
  • hepatomegaly/liver enlargement (excluding storage disease)
  • cutaneous rash
  • neoplasms/tumors

Drugs & Therapeutics for Hodgkin's Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Genetic Tests for Hodgkin's Lymphoma

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Sources:
22GTR
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Genetic tests related to Hodgkin's Lymphoma:

id Genetic test Affiliating Genes
1 Hodgkin Lymphoma22

Anatomical Context for Hodgkin's Lymphoma

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Hodgkin's Lymphoma:

32
B cells, Bone, Lymph node, T cells, Bone marrow, Lung, Breast, Liver, Skin, Testes, Thyroid, Endothelial, Salivary gland, Myeloid, Prostate, Monocytes, Adrenal gland, Testis, Small intestine, Spleen, Nk cells, Colon, Thymus, Spinal cord, Kidney, Pituitary, Ovary, Brain, Heart, Cervix, Tonsil

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Hodgkin's Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Hodgkin's Lymphoma or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Hodgkin's Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.6BCL6, BRAF, PDCD1, TNFSF8, MDM2, RHOH
2MP:000539712.2BRAF, PDCD1, MDM2, RHOH, LTA, REL
3MP:000538412.2LTA, RHOH, MDM2, PDCD1, BRAF, REL
4MP:000537011.5PDCD1, MDM2, LTA, REL, BCL6, BRAF

Publications for Hodgkin's Lymphoma

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Sources:
50PubMed
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Articles related to Hodgkin's Lymphoma:

(show top 50)    (show all 1916)
idTitleAuthorsYear
1
Hodgkin's lymphoma involving extranodal sites: potential association with HIV infection and the implications for clinical management. (23369727)
2013
2
Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury. (24195693)
2013
3
Study of the prevalence of azoospermia in patients with Hodgkin's lymphoma prior to treatment. (24223388)
2013
4
An unusual presentation of Hodgkin's lymphoma: ectopic testicular involvement. (24012625)
2013
5
Sequential Hodgkin's and non-Hodgkin's lymphoma in non-immunocompromised patients. (23558907)
2013
6
Role of F-18 FDG PET/CT in assessing bone marrow involvement in pediatric Hodgkin's lymphoma. (23143537)
2013
7
The European Medicines Agency review of pixantrone for the treatment of adult patients with multiply relapsed or refractory aggressive non-Hodgkin's B-cell lymphomas: summary of the scientific assessment of the committee for medicinal products for human use. (23615696)
2013
8
Treatment challenges in the management of relapsed or refractory non-Hodgkin's lymphoma - novel and emerging therapies. (24049458)
2013
9
Assessing DcR3 expression in relation to survivin and other prognostic factors in B cell non-Hodgkin's lymphoma. (23652586)
2013
10
Significance of copper level in serum and routine laboratory parameters in estimation of outspreading of Hodgkin's lymphoma. (23848039)
2013
11
Concurrent infection of hepatitis B virus negatively affects the clinical outcome and prognosis of patients with non-Hodgkin's lymphoma after chemotherapy. (23861969)
2013
12
Anti-neoplastic effects of fucoxanthin and its deacetylated product, fucoxanthinol, on Burkitt's and Hodgkin's lymphoma cells. (22859062)
2012
13
(99m)Tc(CO)(3)-Ibritumomab tiuxetan; a novel radioimmunoimaging (RII) agent of B cell non-Hodgkin's lymphoma (NHL). (22628300)
2012
14
Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin's lymphoma. (23264893)
2012
15
Paraneoplastic cerebellar degeneration in Hodgkin's lymphoma. (22919195)
2012
16
Response to "Role of FDG-PET in the definition and management of involved-field radiation therapy for pediatric Hodgkin's lymphoma."Int J Radiat Oncol Biol Phys (2011;80:324-332). (22182722)
2012
17
Primary intestinal non-Hodgkin's lymphoma: a clinicopathologic analysis of 81 patients. (22147970)
2011
18
IL-9 contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin's lymphoma. (21898141)
2011
19
Interplay of parathyroid hormone-related peptide (PTHrP), renal insufficiency and bulky disease in the pathogenesis of hypercalcemia in Hodgkin's lymphoma (HL). (20561035)
2010
20
HLA-G protein expression as a potential immune escape mechanism in classical Hodgkin's lymphoma. (18257895)
2008
21
Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma. (17096334)
2007
22
Non-Hodgkin's lymphoma associated with leiomyomatosis presenting with intense pruritus. (17340029)
2007
23
Allelic expression and quantitative RT-PCR study of TAp73 and DeltaNp73 in non-Hodgkin's lymphomas. (16083956)
2006
24
Plasma kinetics of a cholesterol-rich microemulsion (LDE) in patients with Hodgkin's and non-Hodgkin's lymphoma and a preliminary study on the toxicity of etoposide associated with LDE. (16133527)
2006
25
Treatment of indolent non-Hodgkin's lymphoma with cladribine as single-agent therapy and in combination with mitoxantrone. (15218957)
2004
26
Expression of survivin and caspase-3 in non-Hodgkin's lymphoma and their clinical significance]. (14720372)
2004
27
Guideline for radioimmunotherapy of rituximab relapsed or refractory CD20(+) follicular B-cell non-Hodgkin's lymphoma]. (15480506)
2004
28
Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. (12824192)
2003
29
Treatment of relapsed B-cell non-Hodgkin's lymphoma with a combination of chimeric anti-CD20 monoclonal antibodies (rituximab) and G-CSF: final report on safety and efficacy. (12886256)
2003
30
Granulocyte colony-stimulating factor in induction treatment of children with non-Hodgkin's lymphoma: a randomized study of the French Society of Pediatric Oncology. (11786572)
2002
31
Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin's Lymphoma Classification Project. (11863096)
2002
32
Long lasting myelodysplastic syndrome complicated by autoimmune hemolytic anemia and non-Hodgkin's lymphoma. (11982620)
2002
33
Nonmyeloablative allogeneic stem cell transplantation for refractory Hodgkin's lymphoma complicated by interleukin-2 responsive progressive multifocal leukoencephalopathy. (12185517)
2002
34
Phase II study of fludarabine combined with interferon-alpha-2a followed by maintenance therapy with interferon-alpha-2a in patients with low-grade non-hodgkin's lymphoma. (12151972)
2002
35
Hodgkin's disease after treatment for Burkitt's lymphoma: case report. (12002116)
2001
36
Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis. (11297268)
2001
37
A case of adult-onset Still's disease complicated by non-Hodgkin's lymphoma. (10981654)
2000
38
Clinical significance of cyclin-dependent kinase inhibitor p27Kip1 expression and proliferation in non-Hodgkin's lymphoma: independent prognostic value of p27Kip1. (10354138)
1999
39
Primary adrenal non-Hodgkin's lymphoma associated with autoimmune hemolytic anemia: a case diagnosed by ultrasound-guided fine needle biopsy. (10638023)
1999
40
Paraneoplastic pemphigus occurring in a patient with B-cell non-Hodgkin's lymphoma. (9515216)
1998
41
Apoptosis and proliferative activity of non-Hodgkin's lymphomas: comparison with expression of bcl-2, p53 and c-myc proteins. (9088026)
1997
42
Randomized trial with or without granulocyte colony-stimulating factor as adjunct to induction VNCOP-B treatment of elderly high-grade non-Hodgkin's lymphoma. (9166835)
1997
43
Interleukin-13 responsiveness and interleukin-13 receptor expression in non-Hodgkin's lymphoma and reactive lymph node B cells. Modulation by CD40 activation. (9110144)
1997
44
The morphologic spectrum of non-Hodgkin's lymphomas with BCL1/cyclin D1 gene rearrangements. (8619427)
1996
45
Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans. (8645587)
1996
46
Paraneoplastic pemphigus in a patient with non-Hodgkin's lymphoma. (8638613)
1996
47
Malabsorption associated with a high-grade-malignant non-Hodgkin's lymphoma, alpha-heavy-chain disease and immunoproliferative small intestinal disease. (7793120)
1995
48
Determination of the growth fraction in non-Hodgkin's lymphomas by monoclonal antibody Ki-S5 directed against a formalin-resistant epitope of the Ki-67 antigen. (7685150)
1993
49
Adrenocortical insufficiency: a rare presentation of non-Hodgkin's lymphoma. (1851201)
1991
50
Chemotherapists' need for uniform and rational nomenclature and classification of common lymphosarcomas and reticulosarcoma (hematosarcomas or non-Hodgkin's lymphomas). (373918)
1978

Genetic Variations for Hodgkin's Lymphoma

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Expression for genes affiliated with Hodgkin's Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hodgkin's Lymphoma

Search GEO for disease gene expression data for Hodgkin's Lymphoma.

Pathways for genes affiliated with Hodgkin's Lymphoma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5CFLAR, LTA, MDM2, TNFSF8, CASP10, BRAF
2
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11.3BRAF, CASP10, TNFSF8, LTA, CFLAR
3
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11.3BRAF, CASP10, MDM2, LTA, CFLAR
4
Hide members
11.1CFLAR, LTA, MDM2, CASP10
511.1MDM2, REL, PAX5, BCL6
6
Hide members
11.0REL, LTA, CASP10
7
Hide members
11.0REL, LTA, CASP10
8
Hide members
11.0REL, LTA, BRAF
911.0CASP10, LTA, CFLAR
10
Hide members
11.0CFLAR, LTA, CASP10
1111.0MDM2, REL, NBN

Compounds for genes affiliated with Hodgkin's Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.7MDM2, PDCD1, CARD16, BRAF, RHOH, LTA
2paraffin4412.0BRAF, MDM2, LTA, FSCN1, MS4A1, PAX5
3threonine4412.0BRAF, MDM2, LTA, REL, FSCN1, CFLAR
4calcium44 49 11 2414.8BRAF, MDM2, LTA, REL, FSCN1, CFLAR
5oligonucleotide4411.8BRAF, MDM2, LTA, REL, CFLAR, PAX5
6retinoic acid44 2412.7BRAF, LTA, REL, FSCN1, CFLAR, BCL6
7serine4411.7NBN, CFLAR, FSCN1, LTA, CASP10
8rituximab44 49 1113.5CFLAR, MS4A1, PAX5, BCL6
9irinotecan44 49 1113.5CFLAR, MDM2, CARD16, BRAF
10camptothecin44 59 1113.5CARD16, MDM2, CFLAR, NBN
11imatinib44 49 1113.4BCL6, CFLAR, MDM2, BRAF
12etoposide44 49 59 1114.4NBN, CFLAR, MDM2, CARD16
1312-o-tetradecanoylphorbol 13-acetate4411.4BRAF, LTA, FSCN1, BCL6
14rapamycin4411.3NBN, CFLAR, MDM2, BRAF
15dutp4411.3CARD16, MDM2, CFLAR
16doxorubicin44 49 1113.3BCL6, NBN, CFLAR, MDM2
17paclitaxel44 49 1113.2CFLAR, MDM2, BRAF
18geldanamycin44 49 59 1114.2BRAF, MDM2, CFLAR
19estradiol44 11 2413.1PAX5, CFLAR, LTA, MDM2
20vincristine44 49 1113.1MDM2, CFLAR, BCL6
21actinomycin d4411.0CASP10, MDM2, LTA, CFLAR
22p0024411.0BRAF, MDM2, CFLAR
237,12-dimethylbenz(a)anthracene4410.5REL, MDM2

GO Terms for genes affiliated with Hodgkin's Lymphoma

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Sources:
16Gene Ontology
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Cellular components related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.8BCL6, NBN

Biological processes related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:00691511.2NBN, CFLAR, LTA, TNFSF8, PDCD1, CASP10
2humoral immune responseGO:00695911.0PAX5, LTA, PDCD1

Molecular functions related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase activityGO:00419711.0CFLAR, CARD16, CASP10

Products for genes affiliated with Hodgkin's Lymphoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hodgkin's Lymphoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet