HL
MCID: HDG007
MIFTS: 80

Hodgkin's Lymphoma (HL) malady

Cancer, Blood categories

Summaries for Hodgkin's Lymphoma

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Hodgkin disease is a type of lymphoma. lymphoma is a cancer of a part of the immune system called the lymph system. the first sign of hodgkin disease is often an enlarged lymph node. the disease can spread to nearby lymph nodes. later it may spread to the lungs, liver, or bone marrow. the exact cause is unknown. hodgkin disease is rare. symptoms include painless swelling of the lymph nodes in the neck, armpits, or groin fever and chills night sweats weight loss loss of appetite itchy skin to diagnose hodgkin disease, doctors use a physical exam and history, blood tests, and a biopsy. treatment depends on how far the disease has spread. it often includes radiation therapy or chemotherapy. the earlier the disease is diagnosed, the more effective the treatment. in most cases, hodgkin disease can be cured. nih: national cancer institute

MalaCards: Hodgkin's Lymphoma, also known as hodgkin disease, is related to lymphoma, diffuse large cell and follicular lymphoma, and has symptoms including lymphadenopathy/polyadenopathies, immunodeficiency/increased susceptibility to infections/recurrent infections and lymphoma. An important gene associated with Hodgkin's Lymphoma is KLHDC8B (kelch domain containing 8B), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The drugs carmustine and chlorambucil and the compounds tyrosine and paraffin have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A lymphoma that is marked by the presence of a type of cell called the reed-sternberg cell.

Wikipedia:64 Hodgkin lymphoma, also known as Hodgkin\'s lymphoma and Hodgkin\'s disease, is a type of lymphoma, which... more...

Description from OMIM:47 236000,300221,400021

Aliases & Classifications for Hodgkin's Lymphoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 31LifeMap Discovery™, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 9diseasecard, 47OMIM, 22GTR, 49Orphanet, 40NCIt, 27ICD9CM, 57SNOMED-CT, 35MeSH, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
classical hodgkin's lymphoma:
Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

hodgkin's lymphoma 8 43 31
hodgkin disease 8 43 45 34 61
hodgkin lymphoma 9 43 47
classical hodgkin's lymphoma 49 61
hodgkin lymphoma, classical 49 47
lymphoma, hodgkin's 43 22
hodgkins lymphoma 8 10
hodgkin's disease of lymph nodes of inguinal region and/or lower limb 61
hodgkin's disease of intrapelvic lymph nodes 61
stage ii subdiaphragmatic hodgkin lymphoma 8
stage i subdiaphragmatic hodgkin lymphoma 8
classical hodgkin's disease 49
classical hodgkin disease 49
hodgkin's sarcoma 8
hl 8


Related Diseases for Hodgkin's Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hodgkin's Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 345)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, diffuse large cell31.1MS4A1, PAX5, BCL6
2follicular lymphoma31.0REL, MS4A1, PAX5, BCL6
3anaplastic large cell lymphoma30.9BCL6, PAX5, FSCN1, TNFSF8
4non-hodgkin lymphoma30.9NBN, PAX5, MS4A1, CFLAR, FSCN1, MDM2
5hepatitis c30.8PAX5
6lymphoblastic lymphoma30.8BCL6, PAX5, MS4A1
7mantle cell lymphoma30.8BCL6, MDM2
8acute leukemia30.8PAX5
9peripheral t-cell lymphoma30.7LTA, MS4A1, PAX5, BCL6
10b-cell lymphomas30.5MDM2, CHRDL1, REL, FSCN1, CFLAR, MS4A1
11central nervous system lymphoma30.5BCL6
12burkitt's lymphoma30.4MDM2, CFLAR, MS4A1, PAX5, BCL6
13adenocarcinoma30.3BRAF, CARD16, MDM2, FSCN1, CFLAR
14ataxia telangiectasia30.3NBN, MDM2
15colorectal cancer30.2BRAF, MDM2, FSCN1, CFLAR, NBN
16arthritis30.2LTA, CFLAR
17familial non-hodgkin lymphoma30.2CASP10, BRAF
18central nervous system lymphoma, primary30.2BCL6, PAX5
19adenoma30.0FSCN1, TNFSF8, BRAF
20stomach cancer30.0BRAF, CASP10, LTA, FSCN1, CFLAR
21bladder carcinoma30.0MDM2, LTA, CFLAR, PAX5
22thyroid cancer29.9BRAF, CFLAR
23b-cell chronic lymphocytic leukemia29.9PAX5, MS4A1
24systemic lupus erythematosus29.8PDCD1
25nodular lymphocyte predominant hodgkin lymphoma10.9
26hodgkin lymphoma, childhood10.7
27adult lymphoma10.6
28bone lymphoma10.6
29pediatric lymphoma10.6
30colon lymphoma10.5
31t-cell leukemia10.5
32leukemia/lymphoma, t-cell10.5
33autoimmune hemolytic anemia10.5
34composite lymphoma10.5
35breast lymphoma10.4
36n syndrome10.4
37hepatitis a10.4
38hematopoietic stem cell transplantation10.4
39hepatitis c virus10.4
40hodgkin's lymphoma, nodular sclerosis10.4
41ovarian lymphoma10.4
42kaposi's sarcoma10.4
43diffuse large b-cell lymphoma10.4
44leukemia, t-cell, chronic10.4
45lymphocyte-rich classical hodgkin lymphoma10.4
46gastric lymphoma10.3
47progressive multifocal leukoencephalopathy10.3
48orbit lymphoma10.3
49hepatitis d10.3
50infectious mononucleosis10.3

Graphical network of the top 20 diseases related to Hodgkin's Lymphoma:



Diseases related to hodgkin's lymphoma

Clinical Features for Hodgkin's Lymphoma

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

236000,300221,400021

Clinical synopsis from OMIM:

236000

Symptoms:

49 (show all 23)
  • lymphadenopathy/polyadenopathies
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • lymphoma
  • asthenia/fatigue/weakness
  • hyperhidrosis/increased sweating
  • pruritus/itching
  • thoracic/chest pain
  • cough
  • anorexia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • cutaneous rash
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • hemoptysis
  • peripheral neuropathy
  • facial pain/cephalalgia/migraine
  • ataxia/incoordination/trouble of the equilibrium
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone pain
  • bone marrow failure/pancytopenia
  • neoplasms/tumors

Drugs & Therapeutics for Hodgkin's Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Hodgkin's Lymphoma

Sources:
22GTR
See all sources

Genetic tests related to Hodgkin's Lymphoma:

id Genetic test Affiliating Genes
1 Hodgkin Lymphoma22

Anatomical Context for Hodgkin's Lymphoma

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Hodgkin's Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Hodgkin's Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hodgkin's Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.6BCL6, BRAF, PDCD1, TNFSF8, MDM2, RHOH
2MP:000539712.2BRAF, PDCD1, MDM2, RHOH, LTA, REL
3MP:000538412.2LTA, RHOH, MDM2, PDCD1, BRAF, REL
4MP:000537011.5PDCD1, MDM2, LTA, REL, BCL6, BRAF

Publications for Hodgkin's Lymphoma

Sources:
51PubMed
See all sources

Articles related to Hodgkin's Lymphoma:

(show top 50)    (show all 1572)
idTitleAuthorsYear
1
Unilateral lower extremity swelling as a rare presentation of non-Hodgkin's lymphoma. (24431414)
2014
2
Lifestyle factors, autoimmune disease and family history in prognosis of non-hodgkin lymphoma overall and subtypes. (23160780)
2013
3
Study of the prevalence of azoospermia in patients with Hodgkin's lymphoma prior to treatment. (24223388)
2013
4
Rituximab faster infusion for patients with non-Hodgkin's lymphoma in the United States: implications for nursing practice. (23558916)
2013
5
Sequential Hodgkin's and non-Hodgkin's lymphoma in non-immunocompromised patients. (23558907)
2013
6
Neurological complication of non Hodgkin lymphoma in childhood: experience from a single center in Turkey. (23989474)
2013
7
B-cell non-Hodgkin lymphoma of the ethmoid sinus. (23670337)
2013
8
Dangling the carrot of improved survival in non-Hodgkin lymphoma: does carotenoid consumption make a difference? (23597138)
2013
9
Effective use of small-interfering RNA to characterize residual B-cell non-Hodgkin lymphoma cells following chemotherapy. (23125882)
2012
10
Expected long-term survival of older patients diagnosed with non-Hodgkin lymphoma in 2008-2012. (21959230)
2012
11
Synchronous bilateral breast carcinoma and axillary non-hodgkin lymphoma: a case report and review of the literature. (23050177)
2012
12
High-dose therapy and autologous stem cell transplant for transformed non-Hodgkin lymphoma in the rituximab era. (22023518)
2012
13
Sexual well-being among survivors of non-Hodgkin lymphoma. (21875831)
2011
14
Non-Hodgkin lymphoma in childhood and adolescence: frequency and distribution of immunomorphological types from a tertiary care center in South India. (21633853)
2011
15
A large single-center experience with allogeneic stem-cell transplantation for peripheral T-cell non-Hodgkin lymphoma and advanced mycosis fungoides/Sezary syndrome. (21252059)
2011
16
90Y-ibritumomab tiuxetan as consolidation therapy after autologous stem cell transplantation in aggressive non-Hodgkin lymphoma. (21571787)
2011
17
Case studies of elderly patients with non-Hodgkin's lymphoma. (22586515)
2011
18
Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival. (20029944)
2010
19
Serum thymidine kinase 1 concentration as a prognostic factor of chemotherapy-treated non-Hodgkin's lymphoma patients. (20140744)
2010
20
Primary non-Hodgkin's lymphoma of the salivary gland: a spectrum of lymphoepithelial sialadenitis, low-grade B-cell lymphoma of mucosa-associated lymphoid tissue with transformation to high-grade lymphoma. (20551561)
2010
21
Phase 2 study of intrathecal, long-acting liposomal cytarabine in the prophylaxis of lymphomatous meningitis in human immunodeficiency virus-related non-Hodgkin lymphoma. (20108270)
2010
22
Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies. (19414860)
2009
23
Brazilian experience using high-dose sequential chemotherapy followed by autologous hematopoietic stem cell transplantation for relapsed or refractory Hodgkin lymphoma. (19951885)
2009
24
Clinical, endoscopic and prognostic aspects of primary gastric non-hodgkin's lymphoma associated with acquired immunodeficiency syndrome. (19578621)
2009
25
Pre-treatment serum levels of interleukin-10, interleukin-12 and their ratio predict response to therapy and probability of event-free and overall survival in childhood soft tissue sarcomas, Hodgkin's lymphomas and acute lymphoblastic leukemias. (19376105)
2009
26
Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines. (18541724)
2008
27
Cost benefit and clinical efficacy of low-dose granulocyte colony-stimulating factor after standard chemotherapy in patients with non-Hodgkin's lymphoma. (18665826)
2008
28
A case of nodular sclerosis Hodgkin's lymphoma repeatedly relapsing in the context of composite plasma cell-hyaline vascular Castleman's disease: successful response to rituximab and radiotherapy. (17908180)
2007
29
The role of stromal cell derived factor-1/CXCR4 biological axis in tumor metastasis of non-Hodgkin lymphoma]. (17553309)
2007
30
Abdominal pain and syndrome of inappropriate antidiuretic hormone secretion as a manifestation of visceral varicella zoster virus infection in a patient with non-Hodgkin's lymphoma. (17133427)
2007
31
Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study. (17119116)
2007
32
Effect of granulocyte colony-stimulating factor on IL-12 p40 production during chemotherapy for B-cell lineage non-Hodgkin's lymphoma patients. (16930137)
2006
33
Single nucleotide polymorphism in 5'-flanking region of BCL6 is not associated with increased risk of non-Hodgkin's lymphoma. (16125304)
2006
34
Relapsing granulomatous angiitis of the central nervous system in a patient while in remission from Hodgkin lymphoma. (17144241)
2006
35
Early changes in serum IL-6 and VEGF levels predict clinical outcome following first-line therapy in aggressive non-Hodgkin's lymphoma. (15834569)
2005
36
Alterations of loci encoding PU.1, BOB1, and OCT2 transcription regulators do not correlate with their suppressed expression in Hodgkin lymphoma. (15796964)
2005
37
Treatment of indolent non-Hodgkin's lymphoma with cladribine as single-agent therapy and in combination with mitoxantrone. (15218957)
2004
38
Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma. (15289331)
2004
39
Blood serum levels of soluble forms of adhesion molecules ICAM-1 (sICAM-1) and selectin E (s-selectin E) in patients with various phases of non-Hodgkin's lymphomas. (12011765)
2002
40
Composite germ cell tumor and B-cell non-Hodgkin's lymphoma arising in the sella turcica. (12395379)
2002
41
Expression of adhesion molecules LFA-1, ICAM-1, CD44, and L-selectin in childhood non-Hodgkin lymphomas. (11241437)
2001
42
Acute hematologic toxicity and practicability of dose-intensified BEACOPP chemotherapy for advanced stage Hodgkin's disease. German Hodgkin's Lymphoma Study Group (GHSG). (11061603)
2000
43
Large cell non-Hodgkin lymphoma of childhood: Analysis of 78 consecutive patients enrolled in 2 consecutive protocols at the Memorial Sloan-Kettering Cancer Center. (10618623)
2000
44
Differentiation of antitumor-specific cytotoxic T lymphocytes from autologous tumor infiltrating lymphocytes in non-Hodgkin's lymphomas. (10390194)
1999
45
Clinical significance of cyclin-dependent kinase inhibitor p27Kip1 expression and proliferation in non-Hodgkin's lymphoma: independent prognostic value of p27Kip1. (10354138)
1999
46
Chemotherapy and granulocyte-colony stimulating factor for non-Hodgkin's lymphoma of the head and neck. (8908287)
1996
47
Primary Epstein-Barr virus-related non-Hodgkin's lymphoma of the pleural cavity following long-standing tuberculous empyema. (8629908)
1996
48
Granulocyte colony-stimulating factor following peripheral-blood progenitor-cell transplant in non-Hodgkin's lymphoma. (7535843)
1995
49
PCR-based assays for the detection of monoclonality in non-Hodgkin's lymphoma: application to formalin-fixed, paraffin-embedded tissue and decalcified bone marrow samples. (7670927)
1995
50
Three new monoclonal antibodies that define a unique antigen associated with prolymphocytic leukemia/non-Hodgkin's lymphoma and are effectively internalized after binding to the cell surface antigen. (8417805)
1993

Genetic Variations for Hodgkin's Lymphoma

Expression for genes affiliated with Hodgkin's Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hodgkin's Lymphoma

Search GEO for disease gene expression data for Hodgkin's Lymphoma.

Pathways for genes affiliated with Hodgkin's Lymphoma

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore
See all sources

Pathways related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5CFLAR, LTA, MDM2, TNFSF8, CASP10, BRAF
2
Hide members
11.3BRAF, CASP10, TNFSF8, LTA, CFLAR
3
Hide members
11.3BRAF, CASP10, MDM2, LTA, CFLAR
4
Hide members
11.1CFLAR, LTA, MDM2, CASP10
511.1MDM2, REL, PAX5, BCL6
6
Hide members
11.0REL, LTA, CASP10
7
Hide members
11.0REL, LTA, CASP10
8
Hide members
11.0REL, LTA, BRAF
911.0CASP10, LTA, CFLAR
10
Hide members
11.0CFLAR, LTA, CASP10
1111.0MDM2, REL, NBN

Compounds for genes affiliated with Hodgkin's Lymphoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1tyrosine4512.7MDM2, PDCD1, CARD16, BRAF, RHOH, LTA
2paraffin4512.0BRAF, MDM2, LTA, FSCN1, MS4A1, PAX5
3threonine4512.0BRAF, MDM2, LTA, REL, FSCN1, CFLAR
4calcium45 50 11 2414.8BRAF, MDM2, LTA, REL, FSCN1, CFLAR
5oligonucleotide4511.8BRAF, MDM2, LTA, REL, CFLAR, PAX5
6retinoic acid45 2412.7BRAF, LTA, REL, FSCN1, CFLAR, BCL6
7serine4511.7NBN, CFLAR, FSCN1, LTA, CASP10
8rituximab45 50 1113.5CFLAR, MS4A1, PAX5, BCL6
9irinotecan45 50 1113.5CFLAR, MDM2, CARD16, BRAF
10camptothecin45 60 1113.5CARD16, MDM2, CFLAR, NBN
11imatinib45 50 1113.4BCL6, CFLAR, MDM2, BRAF
12etoposide45 50 60 1114.4NBN, CFLAR, MDM2, CARD16
1312-o-tetradecanoylphorbol 13-acetate4511.4BRAF, LTA, FSCN1, BCL6
14rapamycin4511.3NBN, CFLAR, MDM2, BRAF
15dutp4511.3CARD16, MDM2, CFLAR
16doxorubicin45 50 1113.3BCL6, NBN, CFLAR, MDM2
17paclitaxel45 50 1113.2CFLAR, MDM2, BRAF
18geldanamycin45 50 60 1114.2BRAF, MDM2, CFLAR
19estradiol45 11 2413.1PAX5, CFLAR, LTA, MDM2
20vincristine45 50 1113.1MDM2, CFLAR, BCL6
21actinomycin d4511.0CASP10, MDM2, LTA, CFLAR
22p0024511.0BRAF, MDM2, CFLAR
237,12-dimethylbenz(a)anthracene4510.5REL, MDM2

GO Terms for genes affiliated with Hodgkin's Lymphoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.8BCL6, NBN

Biological processes related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:00691511.2NBN, CFLAR, LTA, TNFSF8, PDCD1, CASP10
2humoral immune responseGO:00695911.0PAX5, LTA, PDCD1

Molecular functions related to Hodgkin's Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase activityGO:00419711.0CFLAR, CARD16, CASP10

Products for genes affiliated with Hodgkin's Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hodgkin's Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet