MCID: HMC004
MIFTS: 33

Homocysteine Plasma Level malady

Summaries for Homocysteine Plasma Level

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34MalaCards
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MalaCards: Homocysteine Plasma Level is related to migraine and migraine with aura. An important gene associated with Homocysteine Plasma Level is NNMT (nicotinamide N-methyltransferase), and among its related pathways are Sulfur amino acid metabolism and Folate Metabolism. The compounds corrinoid and Cob(I)alamin have been mentioned in the context of this disorder. Related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Homocysteine Plasma Level

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48OMIM
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Aliases & Descriptions:

homocysteine plasma level 48


Related Diseases for Homocysteine Plasma Level

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18GeneCards, 19GeneDecks
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Diseases related to Homocysteine Plasma Level via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1migraine10.2
2migraine with aura10.2
3ovarian cancer10.2
4sneddon syndrome10.1SERPINC1
5branch retinal artery occlusion10.1F5
6coronary thrombosis10.1SERPINC1
7neural tube defects, folate-sensitive10.1MTR, MTRR
8disorders of intracellular cobalamin metabolism10.1MTR, MTRR
9homocysteinemia due to mthfr deficiency10.1MTR, MTHFR
10pancytopenia10.1TCN2, DHFR
11methylmalonic acidemia10.1MTR, TCN2
12eclampsia10.1SERPINC1, MTHFR
13chagas disease10.1DHFR, TCN2
14glucose intolerance10.1TCN2, MTR
15megaloblastic anemia10.1TCN2, DHFR, MTR
16central retinal vein occlusion10.0MTHFR, F5
17purpura fulminans10.0SERPINC1, F5
18vitamin b12 deficiency10.0TCN2, MTHFR, MTR
19cerebrovascular disease10.0MTHFR, MTR
20post-thrombotic syndrome10.0SERPINC1, F5
21folic acid deficiency anemia10.0MTR, MTHFR, DHFR
22legg-calve-perthes disease10.0SERPINC1, F5
23prothrombin deficiency10.0SERPINC1, F5
24sagittal sinus thrombosis10.0SERPINC1, F5
25cleft lip10.0MTR, MTRR, MTHFR
26factor xii deficiency10.0F5, SERPINC1
27severe pre-eclampsia10.0SERPINC1, F5
28dysfibrinogenemia10.0SERPINC1, F5
29meningococcemia10.0SERPINC1, F5
30hemorrhagic disease10.0SERPINC1, F5
31factor vii deficiency10.0F5, SERPINC1
32down syndrome10.0MTR, MTRR, MTHFR
33deficiency anemia10.0TCN2, DHFR, MTR
34cleft palate10.0MTR, MTHFR
35factor viii deficiency10.0F5, SERPINC1
36arteriosclerosis10.0MTHFR, EDN1
37congenital heart disease10.0EDN1, MTR
38protein s deficiency10.0F5, SERPINC1
39homocysteinemia10.0F5, MTR, MTHFR
40neural tube defects10.0MTR, MTRR, MTHFR, TCN2
41spina bifida10.0DHFR, MTHFR, MTRR, MTR
42acute lymphocytic leukemia10.0SERPINC1, DHFR, MTHFR
43hepatic vein thrombosis10.0SERPINC1, MTHFR, F5
44retinal vein occlusion10.0F5, MTHFR, SERPINC1
45blood protein disease10.0SERPINC1, MTHFR, F5
46portal vein thrombosis10.0SERPINC1, MTHFR, F5
47antithrombin iii deficiency10.0SERPINC1, MTHFR, F5
48intracranial thrombosis10.0SERPINC1, MTHFR, F5
49placental abruption10.0SERPINC1, MTHFR, F5
50hellp syndrome10.0SERPINC1, MTHFR, F5

Graphical network of the top 20 diseases related to Homocysteine Plasma Level:



Diseases related to homocysteine plasma level

Symptoms for Homocysteine Plasma Level

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Drugs & Therapeutics for Homocysteine Plasma Level

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Homocysteine Plasma Level

Drug clinical trials:

Search ClinicalTrials for Homocysteine Plasma Level

Search NIH Clinical Center for Homocysteine Plasma Level

Search CenterWatch for Homocysteine Plasma Level

Genetic Tests for Homocysteine Plasma Level

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Anatomical Context for Homocysteine Plasma Level

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Animal Models for Homocysteine Plasma Level or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Homocysteine Plasma Level:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3F5, MTR, MTRR, MTHFR, SERPINC1, EDN1

Publications for Homocysteine Plasma Level

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53PubMed
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Articles related to Homocysteine Plasma Level:

idTitleAuthorsYear
1
Genetic polymorphisms relevant for one-carbon metabolism show no effect on homocysteine plasma levels and DNA methylation in alcoholism. (19461557)
2009
2
Homocysteine plasma levels in patients with migraine with aura. (18545927)
2008
3
Age and homocysteine plasma levels are risk factors for thrombotic complications after ovarian stimulation. (15178664)
2004
4
Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients. (12471611)
2003
5
Helicobacter pylori masks differences in homocysteine plasma levels between controls and type 2 diabetic patients. (11895466)
2002
6
Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients. (11431185)
2001
7
Increased prevalence of combined MTR and MTHFR genotypes among individuals with severely elevated total homocysteine plasma levels. (11684547)
2001
8
The effect of the menstrual cycle and of ethinylestradiol on nitric oxide, endothelin-1 and homocysteine plasma levels. (10965936)
2000

Variations for Homocysteine Plasma Level

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Expression for genes affiliated with Homocysteine Plasma Level

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Homocysteine Plasma Level

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Pathways for genes affiliated with Homocysteine Plasma Level

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 52PharmGKB, 61Thomson Reuters, 54QIAGEN, 55R&D Systems
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Pathways related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7MTR, MTRR
2
Show member pathways
Vitamin B12 Metabolism39
9.7MTRR, MTHFR
3
Show member pathways
9.6MTHFR, DHFR
4
Show member pathways
9.4NNMT, MTRR, MTR
5
Show member pathways
9.1F5, SERPINC1
6
Show member pathways
One Carbon Metabolism39
dTMP de novo biosynthesis (mitochondrial)39
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate39
Trans-sulfuration and one carbon metabolism39
methionine salvage39
Methionine metabolism61
8.6MTR, MTRR, MTHFR, DHFR, TCN2
78.6TCN2, DHFR, MTHFR, MTRR, MTR
8
Show member pathways
flavin biosynthesis IV (mammalian)39
molybdenum cofactor biosynthesis39
coenzyme A biosynthesis39
thiamin salvage III39
alanine biosynthesis III39
thio-molybdenum cofactor biosynthesis39
biotin-carboxyl carrier protein assembly39
8.6TCN2, DHFR, MTHFR, MTRR, MTR
9
Show member pathways
8.3NNMT, TCN2, DHFR, MTHFR, MTRR, MTR

Compounds for genes affiliated with Homocysteine Plasma Level

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46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 3BitterDB, 30IUPHAR
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Compounds related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1corrinoid4610.1TCN2, MTR
2Cob(I)alamin2510.1MTR, MTRR
3vitamin b-complex, plain5210.0MTRR, MTHFR
4cob(ii)alamin46 2511.0MTR, MTRR
5methyl-group4610.0MTR, MTHFR
65-Methyltetrahydrofolic acid2510.0MTR, MTHFR
7adenosylcobalamin46 2510.7MTR, TCN2, MTHFR
8folic acid52 25 1211.7MTRR, MTHFR, DHFR
9b vitamins469.7MTRR, MTHFR, MTR
10betaine46 2510.7MTRR, MTR, MTHFR
1110-formyltetrahydrofolate469.6DHFR, MTR, MTHFR
12Tetrahydrofolic acid25 1210.6MTR, DHFR, MTHFR
13dihydrofolate469.6DHFR, MTR, MTHFR
145,10-methenyltetrahydrofolate469.5MTR, MTHFR
15paba469.4DHFR, F5
16inogatran469.4SERPINC1, F5
17methylcobalamin46 2510.4MTHFR, TCN2, MTRR, MTR
18hydroxocobalamin46 1210.4TCN2, MTHFR, MTR, MTRR
19cyanocobalamin52 25 1211.4MTR, MTRR, MTHFR, TCN2
20s-adenosylhomocysteine46 2510.4MTRR, MTR, MTHFR, NNMT
21methylmalonic acid46 2510.4TCN2, MTRR, MTHFR, MTR
22chloroquine46 3 52 30 1213.4SERPINC1, TCN2, DHFR
23cobalamin46 2510.4MTRR, MTHFR, TCN2, MTR
24ecarin469.4F5, SERPINC1
25s-adenosylmethionine46 25 1211.3MTR, MTRR, MTHFR, NNMT
26hirugen469.3SERPINC1, F5
27tetrahydrofolate469.3MTRR, MTR, DHFR, MTHFR
28spectrozyme469.3F5, SERPINC1
29thymidylate469.3MTR, DHFR, MTHFR, MTRR
30methionine469.2MTHFR, TCN2, MTR, MTRR
31methotrexate52 46 1211.2DHFR, MTRR, MTHFR, MTR
32nafamostat mesilate469.2F5, SERPINC1
33danaparoid469.1F5, SERPINC1
34warfarin46 52 25 1211.9MTHFR, SERPINC1, F5
35nadph46 259.9MTR, MTRR, MTHFR, DHFR
36vitamin b6468.9MTR, MTHFR, TCN2, F5
375-methyltetrahydrofolate46 129.9MTHFR, F5, MTR, MTRR
38cyclophosphamide46 52 1210.8DHFR, F5, MTR, MTHFR
39ascorbic acid46 259.6MTHFR, SERPINC1, DHFR, F5
40cystathionine468.6MTR, F5, MTRR, MTHFR, TCN2
41vitamin b12468.6MTR, MTRR, TCN2, MTHFR, F5
42aspartate468.4F5, DHFR, MTHFR, MTRR, MTR
43glutamate468.3DHFR, F5, MTRR, MTHFR, MTR
44arginine467.9F5, DHFR, SERPINC1, EDN1, RFC1
45alanine467.8F5, MTRR, MTHFR, DHFR, RFC1, SERPINC1
46serine467.8F5, SERPINC1, MTHFR, DHFR, MTRR, MTR
47homocysteine46 258.8MTR, SERPINC1, NNMT, TCN2, MTHFR, MTRR
48creatinine467.7EDN1, SERPINC1, F5, MTR, TCN2, MTHFR
49folate467.7MTHFR, F5, SERPINC1, TCN2, DHFR, MTRR
50estrogen467.6MTHFR, DHFR, MTR, SERPINC1, F5

GO Terms for genes affiliated with Homocysteine Plasma Level

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17Gene Ontology
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Cellular components related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2F5, TCN2, SERPINC1, EDN1

Biological processes related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1methionine biosynthetic processGO:0090869.8MTHFR, MTRR
2folic acid metabolic processGO:0466559.7MTRR, MTHFR
3methylationGO:0322599.6MTR, MTRR, NNMT
4cobalamin metabolic processGO:0092359.5MTR, MTRR, TCN2
5xenobiotic metabolic processGO:0068059.4MTR, MTRR, NNMT
6sulfur amino acid metabolic processGO:0000969.4MTR, MTRR
7blood circulationGO:0080159.2F5, MTHFR
8water-soluble vitamin metabolic processGO:0067679.2MTR, MTRR, MTHFR, TCN2
9vitamin metabolic processGO:0067669.1TCN2, MTHFR, MTRR, MTR
10small molecule metabolic processGO:0442818.5NNMT, TCN2, MTHFR, MTRR, MTR

Molecular functions related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1flavin adenine dinucleotide bindingGO:0506609.7MTRR, MTHFR
2cobalamin bindingGO:0314199.6MTR, TCN2
3NADP bindingGO:0506619.4MTRR, MTHFR

Products for genes affiliated with Homocysteine Plasma Level

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Sources for Homocysteine Plasma Level

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet