MCID: HMC004
MIFTS: 33

Homocysteine Plasma Level malady

Download this MalaCard

Summaries for Homocysteine Plasma Level

About this section


Fully expand this MalaCard
MalaCards based summary: Homocysteine Plasma Level is related to sneddon syndrome and branch retinal artery occlusion. An important gene associated with Homocysteine Plasma Level is NNMT (nicotinamide N-methyltransferase), and among its related pathways are Sulfur amino acid metabolism and Folate Metabolism. The compounds corrinoid and Cob(I)alamin have been mentioned in the context of this disorder. Related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Homocysteine Plasma Level

About this section

Homocysteine Plasma Level, Aliases & Descriptions:

Name: Homocysteine Plasma Level 46


Related Diseases for Homocysteine Plasma Level

About this section

Diseases related to Homocysteine Plasma Level via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1sneddon syndrome10.4SERPINC1
2branch retinal artery occlusion10.4F5
3coronary thrombosis10.4SERPINC1
4neural tube defects, folate-sensitive10.3MTRR, MTR
5disorders of intracellular cobalamin metabolism10.3MTRR, MTR
6homocysteinemia due to mthfr deficiency10.3MTHFR, MTR
7pancytopenia10.3DHFR, TCN2
8methylmalonic acidemia10.3TCN2, MTR
9eclampsia10.3MTHFR, SERPINC1
10chagas disease10.3TCN2, DHFR
11glucose intolerance10.3MTR, TCN2
12megaloblastic anemia10.2MTR, TCN2, DHFR
13central retinal vein occlusion10.2F5, MTHFR
14vitamin b12 deficiency10.2TCN2, MTHFR, MTR
15cerebrovascular disease10.2MTR, MTHFR
16post-thrombotic syndrome10.2F5, SERPINC1
17folic acid deficiency anemia10.2DHFR, MTHFR, MTR
18migraine10.2
19migraine with aura10.2
20ovarian cancer10.2
21legg-calve-perthes disease10.2SERPINC1, F5
22prothrombin deficiency10.2F5, SERPINC1
23sagittal sinus thrombosis10.2SERPINC1, F5
24cleft lip10.2MTRR, MTR, MTHFR
25factor xii deficiency10.2SERPINC1, F5
26dysfibrinogenemia10.2SERPINC1, F5
27severe pre-eclampsia10.1SERPINC1, F5
28hemorrhagic disease10.1SERPINC1, F5
29meningococcemia10.1SERPINC1, F5
30factor vii deficiency10.1F5, SERPINC1
31down syndrome10.1MTR, MTRR, MTHFR
32deficiency anemia10.1TCN2, DHFR, MTR
33cleft palate10.1MTHFR, MTR
34factor viii deficiency10.1SERPINC1, F5
35arteriosclerosis10.1EDN1, MTHFR
36congenital heart disease10.1MTR, EDN1
37homocysteinemia10.1MTR, MTHFR, F5
38neural tube defects10.1MTR, TCN2, MTHFR, MTRR
39spina bifida10.0DHFR, MTHFR, MTR, MTRR
40acute lymphoblastic leukemia10.0DHFR, MTHFR, SERPINC1
41hepatic vein thrombosis10.0SERPINC1, MTHFR, F5
42disseminated intravascular coagulation10.0SERPINC1, F5
43retinal vein occlusion10.0F5, MTHFR, SERPINC1
44blood protein disease10.0SERPINC1, F5, MTHFR
45antithrombin iii deficiency10.0F5, MTHFR, SERPINC1
46portal vein thrombosis10.0MTHFR, SERPINC1, F5
47intracranial thrombosis10.0SERPINC1, F5, MTHFR
48protein s deficiency10.0F5, SERPINC1, MTHFR
49hellp syndrome10.0MTHFR, F5, SERPINC1
50placental abruption10.0F5, MTHFR, SERPINC1

Graphical network of the top 20 diseases related to Homocysteine Plasma Level:



Diseases related to homocysteine plasma level

Symptoms for Homocysteine Plasma Level

About this section

Drugs & Therapeutics for Homocysteine Plasma Level

About this section

Drug clinical trials:

Search ClinicalTrials for Homocysteine Plasma Level

Search NIH Clinical Center for Homocysteine Plasma Level

Genetic Tests for Homocysteine Plasma Level

About this section

Anatomical Context for Homocysteine Plasma Level

About this section

Animal Models for Homocysteine Plasma Level or affiliated genes

About this section

MGI Mouse Phenotypes related to Homocysteine Plasma Level:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3F5, MTR, MTRR, MTHFR, SERPINC1, EDN1

Publications for Homocysteine Plasma Level

About this section

Articles related to Homocysteine Plasma Level:

idTitleAuthorsYear
1
Genetic polymorphisms relevant for one-carbon metabolism show no effect on homocysteine plasma levels and DNA methylation in alcoholism. (19461557)
2009
2
Homocysteine plasma levels in patients with migraine with aura. (18545927)
2008
3
Age and homocysteine plasma levels are risk factors for thrombotic complications after ovarian stimulation. (15178664)
2004
4
Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients. (12471611)
2003
5
Helicobacter pylori masks differences in homocysteine plasma levels between controls and type 2 diabetic patients. (11895466)
2002
6
Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients. (11431185)
2001
7
Increased prevalence of combined MTR and MTHFR genotypes among individuals with severely elevated total homocysteine plasma levels. (11684547)
2001
8
The effect of the menstrual cycle and of ethinylestradiol on nitric oxide, endothelin-1 and homocysteine plasma levels. (10965936)
2000

Variations for Homocysteine Plasma Level

About this section

Expression for genes affiliated with Homocysteine Plasma Level

About this section
Expression patterns in normal tissues for genes affiliated with Homocysteine Plasma Level

Search GEO for disease gene expression data for Homocysteine Plasma Level.

Pathways for genes affiliated with Homocysteine Plasma Level

About this section

Pathways related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7MTR, MTRR
2
Show member pathways
Vitamin B12 Metabolism37
9.7MTRR, MTHFR
3
Show member pathways
9.6MTHFR, DHFR
4
Show member pathways
9.4NNMT, MTRR, MTR
5
Show member pathways
9.1F5, SERPINC1
6
Show member pathways
One Carbon Metabolism37
dTMP de novo biosynthesis (mitochondrial)37
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate37
Trans-sulfuration and one carbon metabolism37
methionine salvage37
Methionine metabolism60
8.6MTR, MTRR, MTHFR, DHFR, TCN2
78.6TCN2, DHFR, MTHFR, MTRR, MTR
8
Show member pathways
flavin biosynthesis IV (mammalian)37
molybdenum cofactor biosynthesis37
coenzyme A biosynthesis37
thiamin salvage III37
alanine biosynthesis III37
thio-molybdenum cofactor biosynthesis37
biotin-carboxyl carrier protein assembly37
8.6TCN2, DHFR, MTHFR, MTRR, MTR
9
Show member pathways
8.3NNMT, TCN2, DHFR, MTHFR, MTRR, MTR

Compounds for genes affiliated with Homocysteine Plasma Level

About this section
Sources:
44Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 2BitterDB, 28IUPHAR
See all sources

Compounds related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1corrinoid4410.1TCN2, MTR
2Cob(I)alamin2410.1MTR, MTRR
3vitamin b-complex, plain5010.0MTRR, MTHFR
4cob(ii)alamin44 2411.0MTR, MTRR
5methyl-group4410.0MTR, MTHFR
65-Methyltetrahydrofolic acid2410.0MTR, MTHFR
7adenosylcobalamin44 2410.7MTR, TCN2, MTHFR
8folic acid50 24 1111.7MTRR, MTHFR, DHFR
9b vitamins449.7MTRR, MTHFR, MTR
10betaine44 2410.7MTRR, MTR, MTHFR
1110-formyltetrahydrofolate449.6DHFR, MTR, MTHFR
12Tetrahydrofolic acid24 1110.6MTR, DHFR, MTHFR
13dihydrofolate449.6DHFR, MTR, MTHFR
145,10-methenyltetrahydrofolate449.5MTR, MTHFR
15paba449.4DHFR, F5
16inogatran449.4SERPINC1, F5
17methylcobalamin44 2410.4MTHFR, TCN2, MTRR, MTR
18hydroxocobalamin44 1110.4TCN2, MTHFR, MTR, MTRR
19cyanocobalamin50 24 1111.4MTR, MTRR, MTHFR, TCN2
20s-adenosylhomocysteine44 2410.4MTRR, MTR, MTHFR, NNMT
21methylmalonic acid44 2410.4TCN2, MTRR, MTHFR, MTR
22chloroquine44 2 50 28 1113.4SERPINC1, TCN2, DHFR
23cobalamin44 2410.4MTRR, MTHFR, TCN2, MTR
24ecarin449.4F5, SERPINC1
25s-adenosylmethionine44 24 1111.3MTR, MTRR, MTHFR, NNMT
26hirugen449.3SERPINC1, F5
27tetrahydrofolate449.3MTRR, MTR, DHFR, MTHFR
28spectrozyme449.3F5, SERPINC1
29thymidylate449.3MTR, DHFR, MTHFR, MTRR
30methionine449.2MTHFR, TCN2, MTR, MTRR
31methotrexate50 44 1111.2DHFR, MTRR, MTHFR, MTR
32nafamostat mesilate449.2F5, SERPINC1
33danaparoid449.1F5, SERPINC1
34warfarin44 50 24 1111.9MTHFR, SERPINC1, F5
35nadph44 249.9MTR, MTRR, MTHFR, DHFR
36vitamin b6448.9MTR, MTHFR, TCN2, F5
375-methyltetrahydrofolate44 119.9MTHFR, F5, MTR, MTRR
38cyclophosphamide44 50 1110.8DHFR, F5, MTR, MTHFR
39ascorbic acid44 249.6MTHFR, SERPINC1, DHFR, F5
40cystathionine448.6MTR, F5, MTRR, MTHFR, TCN2
41vitamin b12448.6MTR, MTRR, TCN2, MTHFR, F5
42aspartate448.4F5, DHFR, MTHFR, MTRR, MTR
43glutamate448.3DHFR, F5, MTRR, MTHFR, MTR
44arginine447.9F5, DHFR, SERPINC1, EDN1, RFC1
45alanine447.8F5, MTRR, MTHFR, DHFR, RFC1, SERPINC1
46serine447.8F5, SERPINC1, MTHFR, DHFR, MTRR, MTR
47homocysteine44 248.8MTR, SERPINC1, NNMT, TCN2, MTHFR, MTRR
48creatinine447.7EDN1, SERPINC1, F5, MTR, TCN2, MTHFR
49folate447.7MTHFR, F5, SERPINC1, TCN2, DHFR, MTRR
50estrogen447.6MTHFR, DHFR, MTR, SERPINC1, F5

GO Terms for genes affiliated with Homocysteine Plasma Level

About this section

Cellular components related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2F5, TCN2, SERPINC1, EDN1

Biological processes related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1methionine biosynthetic processGO:0090869.8MTHFR, MTRR
2folic acid metabolic processGO:0466559.7MTRR, MTHFR
3methylationGO:0322599.6MTR, MTRR, NNMT
4cobalamin metabolic processGO:0092359.5MTR, MTRR, TCN2
5xenobiotic metabolic processGO:0068059.4MTR, MTRR, NNMT
6sulfur amino acid metabolic processGO:0000969.4MTR, MTRR
7blood circulationGO:0080159.2F5, MTHFR
8water-soluble vitamin metabolic processGO:0067679.2MTR, MTRR, MTHFR, TCN2
9vitamin metabolic processGO:0067669.1TCN2, MTHFR, MTRR, MTR
10small molecule metabolic processGO:0442818.5NNMT, TCN2, MTHFR, MTRR, MTR

Molecular functions related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1flavin adenine dinucleotide bindingGO:0506609.7MTRR, MTHFR
2cobalamin bindingGO:0314199.6MTR, TCN2
3NADP bindingGO:0506619.4MTRR, MTHFR

Products for genes affiliated with Homocysteine Plasma Level

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Homocysteine Plasma Level

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet