MCID: HMC004
MIFTS: 33

Homocysteine Plasma Level malady

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Summaries for Homocysteine Plasma Level

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33MalaCards
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MalaCards: Homocysteine Plasma Level is related to migraine and migraine with aura. An important gene associated with Homocysteine Plasma Level is NNMT (nicotinamide N-methyltransferase), and among its related pathways are Sulfur amino acid metabolism and Folate Metabolism. The compounds corrinoid and Cob(I)alamin have been mentioned in the context of this disorder. Related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Homocysteine Plasma Level

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47OMIM
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Aliases & Descriptions:

homocysteine plasma level 47


Related Diseases for Homocysteine Plasma Level

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17GeneCards, 18GeneDecks
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Diseases related to Homocysteine Plasma Level via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1migraine10.2
2migraine with aura10.2
3ovarian cancer10.2
4sneddon syndrome10.1SERPINC1
5branch retinal artery occlusion10.1F5
6coronary thrombosis10.1SERPINC1
7neural tube defects, folate-sensitive10.1MTR, MTRR
8disorders of intracellular cobalamin metabolism10.1MTR, MTRR
9homocysteinemia due to mthfr deficiency10.1MTR, MTHFR
10pancytopenia10.1TCN2, DHFR
11methylmalonic acidemia10.1MTR, TCN2
12eclampsia10.1SERPINC1, MTHFR
13chagas disease10.1DHFR, TCN2
14glucose intolerance10.1TCN2, MTR
15megaloblastic anemia10.1TCN2, DHFR, MTR
16central retinal vein occlusion10.0MTHFR, F5
17purpura fulminans10.0SERPINC1, F5
18vitamin b12 deficiency10.0TCN2, MTHFR, MTR
19cerebrovascular disease10.0MTHFR, MTR
20post-thrombotic syndrome10.0SERPINC1, F5
21folic acid deficiency anemia10.0MTR, MTHFR, DHFR
22legg-calve-perthes disease10.0SERPINC1, F5
23prothrombin deficiency10.0SERPINC1, F5
24sagittal sinus thrombosis10.0SERPINC1, F5
25cleft lip10.0MTR, MTRR, MTHFR
26factor xii deficiency10.0F5, SERPINC1
27severe pre-eclampsia10.0SERPINC1, F5
28dysfibrinogenemia10.0SERPINC1, F5
29meningococcemia10.0SERPINC1, F5
30hemorrhagic disease10.0SERPINC1, F5
31factor vii deficiency10.0F5, SERPINC1
32down syndrome10.0MTR, MTRR, MTHFR
33deficiency anemia10.0TCN2, DHFR, MTR
34cleft palate10.0MTR, MTHFR
35factor viii deficiency10.0F5, SERPINC1
36arteriosclerosis10.0MTHFR, EDN1
37congenital heart disease10.0EDN1, MTR
38protein s deficiency10.0F5, SERPINC1
39homocysteinemia10.0F5, MTR, MTHFR
40neural tube defects10.0MTR, MTRR, MTHFR, TCN2
41spina bifida10.0DHFR, MTHFR, MTRR, MTR
42acute lymphocytic leukemia10.0SERPINC1, DHFR, MTHFR
43hepatic vein thrombosis10.0SERPINC1, MTHFR, F5
44retinal vein occlusion10.0F5, MTHFR, SERPINC1
45blood protein disease10.0SERPINC1, MTHFR, F5
46portal vein thrombosis10.0SERPINC1, MTHFR, F5
47antithrombin iii deficiency10.0SERPINC1, MTHFR, F5
48intracranial thrombosis10.0SERPINC1, MTHFR, F5
49placental abruption10.0SERPINC1, MTHFR, F5
50hellp syndrome10.0SERPINC1, MTHFR, F5

Graphical network of the top 20 diseases related to Homocysteine Plasma Level:



Diseases related to homocysteine plasma level

Symptoms for Homocysteine Plasma Level

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Drugs & Therapeutics for Homocysteine Plasma Level

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Homocysteine Plasma Level

Genetic Tests for Homocysteine Plasma Level

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Anatomical Context for Homocysteine Plasma Level

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Animal Models for Homocysteine Plasma Level or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Homocysteine Plasma Level:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3F5, MTR, MTRR, MTHFR, SERPINC1, EDN1

Publications for Homocysteine Plasma Level

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52PubMed
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Articles related to Homocysteine Plasma Level:

idTitleAuthorsYear
1
Genetic polymorphisms relevant for one-carbon metabolism show no effect on homocysteine plasma levels and DNA methylation in alcoholism. (19461557)
2009
2
Homocysteine plasma levels in patients with migraine with aura. (18545927)
2008
3
Age and homocysteine plasma levels are risk factors for thrombotic complications after ovarian stimulation. (15178664)
2004
4
Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients. (12471611)
2003
5
Helicobacter pylori masks differences in homocysteine plasma levels between controls and type 2 diabetic patients. (11895466)
2002
6
Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients. (11431185)
2001
7
Increased prevalence of combined MTR and MTHFR genotypes among individuals with severely elevated total homocysteine plasma levels. (11684547)
2001
8
The effect of the menstrual cycle and of ethinylestradiol on nitric oxide, endothelin-1 and homocysteine plasma levels. (10965936)
2000

Variations for Homocysteine Plasma Level

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Expression for genes affiliated with Homocysteine Plasma Level

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Homocysteine Plasma Level

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Pathways for genes affiliated with Homocysteine Plasma Level

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 51PharmGKB, 60Thomson Reuters, 53QIAGEN, 54R&D Systems
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Pathways related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7MTR, MTRR
2
Show member pathways
Vitamin B12 Metabolism38
9.7MTRR, MTHFR
3
Show member pathways
9.6MTHFR, DHFR
4
Show member pathways
9.4NNMT, MTRR, MTR
5
Show member pathways
9.1F5, SERPINC1
6
Show member pathways
One Carbon Metabolism38
dTMP de novo biosynthesis (mitochondrial)38
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate38
Trans-sulfuration and one carbon metabolism38
methionine salvage38
Methionine metabolism60
8.6MTR, MTRR, MTHFR, DHFR, TCN2
78.6TCN2, DHFR, MTHFR, MTRR, MTR
8
Show member pathways
flavin biosynthesis IV (mammalian)38
molybdenum cofactor biosynthesis38
coenzyme A biosynthesis38
thiamin salvage III38
alanine biosynthesis III38
thio-molybdenum cofactor biosynthesis38
biotin-carboxyl carrier protein assembly38
8.6TCN2, DHFR, MTHFR, MTRR, MTR
9
Show member pathways
8.3NNMT, TCN2, DHFR, MTHFR, MTRR, MTR

Compounds for genes affiliated with Homocysteine Plasma Level

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45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 3BitterDB, 29IUPHAR
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Compounds related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1corrinoid4510.1TCN2, MTR
2Cob(I)alamin2410.1MTR, MTRR
3vitamin b-complex, plain5110.0MTRR, MTHFR
4cob(ii)alamin45 2411.0MTR, MTRR
5methyl-group4510.0MTR, MTHFR
65-Methyltetrahydrofolic acid2410.0MTR, MTHFR
7adenosylcobalamin45 2410.7MTR, TCN2, MTHFR
8folic acid51 24 1111.7MTRR, MTHFR, DHFR
9b vitamins459.7MTRR, MTHFR, MTR
10betaine45 2410.7MTRR, MTR, MTHFR
1110-formyltetrahydrofolate459.6DHFR, MTR, MTHFR
12Tetrahydrofolic acid24 1110.6MTR, DHFR, MTHFR
13dihydrofolate459.6DHFR, MTR, MTHFR
145,10-methenyltetrahydrofolate459.5MTR, MTHFR
15paba459.4DHFR, F5
16inogatran459.4SERPINC1, F5
17methylcobalamin45 2410.4MTHFR, TCN2, MTRR, MTR
18hydroxocobalamin45 1110.4TCN2, MTHFR, MTR, MTRR
19cyanocobalamin51 24 1111.4MTR, MTRR, MTHFR, TCN2
20s-adenosylhomocysteine45 2410.4MTRR, MTR, MTHFR, NNMT
21methylmalonic acid45 2410.4TCN2, MTRR, MTHFR, MTR
22chloroquine45 3 51 29 1113.4SERPINC1, TCN2, DHFR
23cobalamin45 2410.4MTRR, MTHFR, TCN2, MTR
24ecarin459.4F5, SERPINC1
25s-adenosylmethionine45 24 1111.3MTR, MTRR, MTHFR, NNMT
26hirugen459.3SERPINC1, F5
27tetrahydrofolate459.3MTRR, MTR, DHFR, MTHFR
28spectrozyme459.3F5, SERPINC1
29thymidylate459.3MTR, DHFR, MTHFR, MTRR
30methionine459.2MTHFR, TCN2, MTR, MTRR
31methotrexate51 45 1111.2DHFR, MTRR, MTHFR, MTR
32nafamostat mesilate459.2F5, SERPINC1
33danaparoid459.1F5, SERPINC1
34warfarin45 51 24 1111.9MTHFR, SERPINC1, F5
35nadph45 249.9MTR, MTRR, MTHFR, DHFR
36vitamin b6458.9MTR, MTHFR, TCN2, F5
375-methyltetrahydrofolate45 119.9MTHFR, F5, MTR, MTRR
38cyclophosphamide45 51 1110.8DHFR, F5, MTR, MTHFR
39ascorbic acid45 249.6MTHFR, SERPINC1, DHFR, F5
40cystathionine458.6MTR, F5, MTRR, MTHFR, TCN2
41vitamin b12458.6MTR, MTRR, TCN2, MTHFR, F5
42aspartate458.4F5, DHFR, MTHFR, MTRR, MTR
43glutamate458.3DHFR, F5, MTRR, MTHFR, MTR
44arginine457.9F5, DHFR, SERPINC1, EDN1, RFC1
45alanine457.8F5, MTRR, MTHFR, DHFR, RFC1, SERPINC1
46serine457.8F5, SERPINC1, MTHFR, DHFR, MTRR, MTR
47homocysteine45 248.8MTR, SERPINC1, NNMT, TCN2, MTHFR, MTRR
48creatinine457.7EDN1, SERPINC1, F5, MTR, TCN2, MTHFR
49folate457.7MTHFR, F5, SERPINC1, TCN2, DHFR, MTRR
50estrogen457.6MTHFR, DHFR, MTR, SERPINC1, F5

GO Terms for genes affiliated with Homocysteine Plasma Level

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16Gene Ontology
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Cellular components related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2F5, TCN2, SERPINC1, EDN1

Biological processes related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1methionine biosynthetic processGO:0090869.8MTHFR, MTRR
2folic acid metabolic processGO:0466559.7MTRR, MTHFR
3methylationGO:0322599.6MTR, MTRR, NNMT
4cobalamin metabolic processGO:0092359.5MTR, MTRR, TCN2
5xenobiotic metabolic processGO:0068059.4MTR, MTRR, NNMT
6sulfur amino acid metabolic processGO:0000969.4MTR, MTRR
7blood circulationGO:0080159.2F5, MTHFR
8water-soluble vitamin metabolic processGO:0067679.2MTR, MTRR, MTHFR, TCN2
9vitamin metabolic processGO:0067669.1TCN2, MTHFR, MTRR, MTR
10small molecule metabolic processGO:0442818.5NNMT, TCN2, MTHFR, MTRR, MTR

Molecular functions related to Homocysteine Plasma Level according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1flavin adenine dinucleotide bindingGO:0506609.7MTRR, MTHFR
2cobalamin bindingGO:0314199.6MTR, TCN2
3NADP bindingGO:0506619.4MTRR, MTHFR

Products for genes affiliated with Homocysteine Plasma Level

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Sources for Homocysteine Plasma Level

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet