MCID: HRN001
MIFTS: 45

Horner's Syndrome

Categories: Rare diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Horner's Syndrome

MalaCards integrated aliases for Horner's Syndrome:

Name: Horner's Syndrome 12 72 49 24 14
Horner Syndrome 12 24 41 69
Bernard-Horner Syndrome 49 24
Oculosympathetic Palsy 49 24
Cervical Sympathetic Paralysis 12
Cervical Sympathetic Dystrophy 69
Bernard Horner Syndrome 12
Von Passow Syndrome 24

Classifications:



External Ids:

Disease Ontology 12 DOID:11486
ICD10 32 G90.2
MeSH 41 D006732
NCIt 46 C28155

Summaries for Horner's Syndrome

NIH Rare Diseases : 49 Horner's syndromeis a rare condition characterized by miosis (constriction of the pupil), ptosis (drooping of the upper eyelid), and anhidrosis (absence of sweating of the face). It is caused by damage to the sympathetic nerves of the face. The underlying causes of Horner's syndrome vary greatly and may include a tumor, stroke, or other damage to a part of the brain called the brain stem; injury to the carotid artery; and trauma to the brachial plexus. In rare cases, Horner's syndrome is congenital (present from birth) and associated with a lack of pigmentation of the iris (colored part of the eye). Treatment of Horner's syndrome depends on the underlying cause. Last updated: 1/3/2017

MalaCards based summary : Horner's Syndrome, also known as horner syndrome, is related to horner syndrome, congenital and breast rhabdomyosarcoma. An important gene associated with Horner's Syndrome is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways is Sympathetic Nerve Pathway (Neuroeffector Junction). The drugs Anesthetics and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are Decreased viability in esophageal squamous lineage and Increased HPV16-GFP infection

Genetics Home Reference : 24 Horner syndrome is a disorder that affects the eye and surrounding tissues on one side of the face and results from paralysis of certain nerves. Horner syndrome can appear at any time of life; in about 5 percent of affected individuals, the disorder is present from birth (congenital).

Wikipedia : 72 Horner\'s syndrome is a combination of symptoms that arises when a group of nerves known as the... more...

Related Diseases for Horner's Syndrome

Diseases in the Horner's Syndrome family:

Horner Syndrome, Congenital

Diseases related to Horner's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 horner syndrome, congenital 11.2
2 breast rhabdomyosarcoma 10.3 DES MYOD1
3 malignant triton tumor 10.3 DES MYOD1
4 cervical polyp 10.3 DES MYOD1
5 gallbladder sarcoma 10.3 DES MYOD1
6 mesenchymoma 10.3 DES MYOD1
7 spindle cell rhabdomyosarcoma 10.3 DES MYOD1
8 nephrogenic adenofibroma 10.2 KRT7 MYOD1
9 inflammatory leiomyosarcoma 10.2 DES MYOD1
10 malignant fibrous histiocytoma of bone 10.2 DES MYOD1
11 parachordoma 10.2 DES KRT7
12 ovarian benign neoplasm 10.2 DES KRT7
13 benign metastasizing leiomyoma 10.2 DES KRT7
14 medullomyoblastoma 10.2 DES MYOD1
15 malignant fibroxanthoma 10.2 DES MYOD1
16 spindle cell sarcoma 10.2 DES KRT7
17 botryoid rhabdomyosarcoma 10.2 DES MYOD1
18 malignant mesenchymoma 10.2 DES MYOD1
19 muscle cancer 10.2 DES MYOD1
20 spindle cell carcinoma 10.1 DES KRT7
21 carotid artery dissection 10.1
22 rhabdoid cancer 10.1 DES MYOD1
23 chordoma 10.1 DES KRT7
24 desmoplastic small round cell tumor 10.1 DES MYOD1
25 embryonal rhabdomyosarcoma 10.1 DES MYOD1
26 alveolar soft part sarcoma 10.1 DES MYOD1
27 rhabdomyosarcoma 2 10.1 DES MYOD1
28 sarcoma, synovial 10.0 DES KRT7
29 seminal vesicle tumor 9.9 GPC3 KRT7
30 pleural empyema 9.9
31 ovarian endodermal sinus tumor 9.9 GPC3 KRT7
32 ovarian primitive germ cell tumor 9.9 GPC3 KRT7
33 bile duct adenocarcinoma 9.9 GPC3 KRT7
34 ovarian clear cell carcinoma 9.9 GPC3 KRT7
35 intrahepatic cholangiocarcinoma 9.7 GPC3 KRT7
36 embryonal sarcoma 9.7 DES GPC3 MYOD1
37 benign mesothelioma 9.6 DES GPC3 KRT7
38 gastrointestinal system cancer 9.6 GPC3 KRT7
39 hepatoblastoma 9.4 GPC3 KRT7

Graphical network of the top 20 diseases related to Horner's Syndrome:



Diseases related to Horner's Syndrome

Symptoms & Phenotypes for Horner's Syndrome

GenomeRNAi Phenotypes related to Horner's Syndrome according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.43 ADRA1A ADRA2A CD6 DES KRT7 MYOD1
2 Increased HPV16-GFP infection GR00350-A 8.8 ADRA1A DES MYOD1

MGI Mouse Phenotypes related to Horner's Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 ADRA1A ADRA2A CD6 DES GPC3 KRT7

Drugs & Therapeutics for Horner's Syndrome

Drugs for Horner's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 3,Phase 1,Phase 2
2 Anesthetics, Local Phase 3,Phase 1,Phase 2
3 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
4 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2
5
Bupivacaine Approved, Investigational Phase 1, Phase 2 38396-39-3, 2180-92-9 2474
6
Epinephrine Approved, Vet_approved Phase 1, Phase 2 51-43-4 5816
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 1, Phase 2 437-38-7 3345
8
Ketamine Approved, Vet_approved Phase 1, Phase 2 6740-88-1 3821
9
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
10
Midazolam Approved, Illicit Phase 1, Phase 2 59467-70-8 4192
11
Propofol Approved, Investigational, Vet_approved Phase 1, Phase 2 2078-54-8 4943
12 Racepinephrine Approved Phase 1, Phase 2 329-65-7
13
Sevoflurane Approved, Vet_approved Phase 1, Phase 2 28523-86-6 5206
14 Adjuvants, Anesthesia Phase 1, Phase 2
15 Adrenergic Agents Phase 1, Phase 2
16 Adrenergic Agonists Phase 1, Phase 2
17 Adrenergic alpha-Agonists Phase 1, Phase 2
18 Adrenergic beta-Agonists Phase 1, Phase 2
19 Analgesics Phase 1, Phase 2
20 Analgesics, Opioid Phase 1, Phase 2
21 Anesthetics, Dissociative Phase 1, Phase 2
22 Anesthetics, General Phase 1, Phase 2
23 Anesthetics, Inhalation Phase 1, Phase 2
24 Anesthetics, Intravenous Phase 1, Phase 2
25 Anti-Anxiety Agents Phase 1, Phase 2
26 Anti-Arrhythmia Agents Phase 1, Phase 2
27 Anti-Asthmatic Agents Phase 1, Phase 2
28
Atracurium Phase 1, Phase 2 64228-79-1 47319
29 Autonomic Agents Phase 1, Phase 2
30 Bronchodilator Agents Phase 1, Phase 2
31 Cholinergic Agents Phase 1, Phase 2
32 Cholinergic Antagonists Phase 1, Phase 2
33 Diuretics, Potassium Sparing Phase 1, Phase 2
34 Epinephryl borate Phase 1, Phase 2
35 Excitatory Amino Acid Antagonists Phase 1, Phase 2
36 Excitatory Amino Acids Phase 1, Phase 2
37 GABA Agents Phase 1, Phase 2
38 GABA Modulators Phase 1, Phase 2
39 Hypnotics and Sedatives Phase 1, Phase 2
40 Mydriatics Phase 1, Phase 2
41 Narcotics Phase 1, Phase 2
42 Neuromuscular Agents Phase 1, Phase 2
43 Neuromuscular Blocking Agents Phase 1, Phase 2
44 Neuromuscular Nondepolarizing Agents Phase 1, Phase 2
45 Neurotransmitter Agents Phase 1, Phase 2
46 Platelet Aggregation Inhibitors Phase 1, Phase 2
47 Psychotropic Drugs Phase 1, Phase 2
48 Respiratory System Agents Phase 1, Phase 2
49 Sodium Channel Blockers Phase 1, Phase 2
50 Tranquilizing Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Does a Low Volume Ultrasound-Guided Technique Reduce Common Complications of Interscalene Brachial Plexus Block? Completed NCT00497354 Phase 3 Variation in volume of local anesthetic
2 Three-level Injection Paravertebral Block vs General Anesthesia in Mastectomy Completed NCT02065947 Phase 1, Phase 2 fentanyl, propofol, atracurium;lidocaine , adrenaline, ketamine bolus, midazolam;sevoflurane and 50% oxygen in air
3 Horner's SD After Thoracic Epidural Block Completed NCT02130739 Ropivacaine;Propofol;Fentanyl
4 Clinical Efficacy of Supraclavicular Block for Arthroscopic Shoulder Surgery Completed NCT01958801
5 Predictive Factors for Hypotensive Bradycardic Events During Arthroscopic Shoulder Surgery Completed NCT01926561
6 Conventional Versus Posterior Approach in Ultrasound-Guided Parasagittal In-Plane Infraclavicular Brachial Plexus Block Completed NCT02462408
7 Posterior Parasagittal In-Plane Ultrasound-Guided Infraclavicular Brachial Plexus Block Completed NCT02312453
8 Distance for Interscalene Block Completed NCT01568463
9 Pupillometry in Horner's Syndrome Recruiting NCT02978079
10 Continuous Blockade of the Brachial Plexus Recruiting NCT02769429
11 Chemical Block and Electrical Stimulation of the Carotid Body to Treat Refractory Hypertension Recruiting NCT02519868
12 Comparison of Volumes of Local Anesthetics on the Efficiency and Safety of Stellate Ganglion Block for CRPS of the Arm Not yet recruiting NCT03316066

Search NIH Clinical Center for Horner's Syndrome

Cochrane evidence based reviews: horner syndrome

Genetic Tests for Horner's Syndrome

Anatomical Context for Horner's Syndrome

MalaCards organs/tissues related to Horner's Syndrome:

38
Eye, Brain, Testes, Thyroid, Breast, Tongue, B Cells

Publications for Horner's Syndrome

Articles related to Horner's Syndrome:

(show top 50) (show all 546)
# Title Authors Year
1
Dramatic extremity temperature increase and Horner's syndrome after stellate ganglion block. ( 29343589 )
2018
2
Iatrogenic Horner's syndrome: A cause for diagnostic confusion in the emergency department. ( 28680524 )
2017
3
A Ruptured Extra-dural Spinal Arterio-venous Malformation Presenting as Horner's Syndrome: The First Case Report. ( 29142793 )
2017
4
Horner's syndrome in cervico-dorsal tuberculosis: A rare case report. ( 28720996 )
2017
5
Backpack palsy with Horner's syndrome. ( 28536218 )
2017
6
Rhabdomyolysis resulting in concurrent Horner's syndrome and brachial plexopathy: a case report. ( 28321484 )
2017
7
Left parapharyngeal ectopic goitre associated with eutopic thyroid and postoperative Horner's syndrome. ( 28215490 )
2017
8
Hemodynamic instability and Horner's syndrome following a labour lumbar neuraxial block: A warning sign of a potentially lethal event? ( 28116954 )
2017
9
Cervical Arteriovenous Malformation Causing Horner's Syndrome. ( 28219497 )
2017
10
Unusual Horner's Syndrome in Recurrent Breast Cancer: Evaluation Using (18)F-FDG PET/CT. ( 28250864 )
2017
11
Spontaneous cervical intradural disc herniation presenting with Brown-SAcquard and Horner's syndrome: lesson learned from a very unique case. ( 28343313 )
2017
12
Rare Complications of Cervical Spine Surgery: Horner's Syndrome. ( 28451480 )
2017
13
Metastatic testicular cancer, a Horner's syndrome and brachial plexopathy. ( 28472531 )
2017
14
Horner's Syndrome in a Case of Granulocytic Sarcoma. ( 28596669 )
2017
15
A rare presentation of spontaneous internal carotid artery dissection with Horner's syndrome, VIIth, Xth and XIIth nerve palsies. ( 27699055 )
2016
16
Unique Case of Pseudomembranous Aspergillus Tracheobronchitis: Tracheal Perforation and Horner's Syndrome. ( 27255521 )
2016
17
Horner's syndrome: an unusual complication of thyroidectomy: a case report. ( 27784321 )
2016
18
Horner's Syndrome Incidental to Medullary Thyroid Carcinoma Excision: Case Report and Brief Literature Review. ( 27200201 )
2016
19
Heralding Extramedullary Blast Crisis: Horner's Syndrome with Brachial Plexopathy in a Patient with Chronic Myelogenous Leukemia. ( 28096817 )
2016
20
Post-thyroidectomy iatrogenic Horner's syndrome with heterochromia. ( 27239603 )
2016
21
Uncommon cause of Horner's syndrome. ( 27566214 )
2016
22
Horner's Syndrome after Scalene Block and Carotid Dissection. ( 26899514 )
2016
23
Horner's Syndrome due to a Spontaneous Internal Carotid Artery Dissection after Deep Sea Scuba Diving. ( 27525139 )
2016
24
Horner's syndrome subsequent to minimally invasive video-assisted thyroidectomy in two patients. ( 26171051 )
2015
25
Erythema migrans associated with partial Horner's syndrome. ( 26643187 )
2015
26
Minor's Test: Objective Demonstration of Horner's Syndrome. ( 26075177 )
2015
27
Horner's syndrome in patients admitted to the intensive care unit that have undergone central venous catheterization: a prospective study. ( 26381100 )
2015
28
Horner's Syndrome Secondary to Epidural Anaesthesia Following Posterior Instrumented Scoliosis Correction. ( 25705345 )
2015
29
Granular cell tumor of the stellate ganglion presenting with Horner's syndrome. ( 26094560 )
2015
30
First Rib Fracture Resulting in Horner's Syndrome. ( 26375810 )
2015
31
Horner's Syndrome after Superficial Cervical Plexus Block. ( 25987922 )
2015
32
Horner's syndrome in a patient presenting with chest pain. ( 26228195 )
2015
33
Brown-SAcquard syndrome without vascular injury associated with Horner's syndrome after a stab injury to the neck. ( 25659820 )
2015
34
Osteochondroma of the clavicle causing Horner's syndrome. ( 26385940 )
2015
35
Transient Horner's syndrome following thoracic epidural anesthesia for mastectomy: a prospective observational study. ( 25560203 )
2015
36
A Case of Mediastinal Granular Cell Tumor with Horner's Syndrome. ( 26041255 )
2015
37
Horner's syndrome: An unusual presentation of metastatic disease in breast cancer. ( 26405267 )
2015
38
Eye on Children: Acute Work-up for Pediatric Horner's Syndrome. Case Presentation and Review of the Literature. ( 25281181 )
2014
39
Rapidly enlarging neck masses of the thyroid with Horner's syndrome: A concise clinical review. ( 25073932 )
2014
40
Congenital lingual hemihyperplasia, Horner's syndrome, and agenesis of the internal carotid artery. ( 24938148 )
2014
41
Delayed Horner's syndrome following ultrasound- guided interscalene brachial plexus block. ( 24665252 )
2014
42
Horner's syndrome secondary to intervertebral disc herniation at the level of T1-2. ( 24903729 )
2014
43
Horner's syndrome and weakness of upper limb after epidural anaesthesia for caesarean section. ( 25197119 )
2014
44
Horner's Syndrome: A Case Report and Review of Pathophysiology and Clinical Features. ( 25314289 )
2014
45
Horner's syndrome after paediatric cardiac surgery: case report and review of the literature. ( 24717921 )
2014
46
Horner's syndrome due to cervical myelopathy. ( 25341945 )
2014
47
Brain Metastases of Papillary Thyroid Carcinoma with Horner's Syndrome. ( 25408940 )
2014
48
Horner's Syndrome Following Internal Carotid Artery Stent Placement. ( 25422713 )
2014
49
Transient unilateral brachial plexopathy and partial Horner's syndrome following spinal anesthesia for cesarean section. ( 24803773 )
2014
50
Visual Hallucinations in a Patient with Horner's Syndrome Secondary to Internal Carotid Dissection. ( 25473403 )
2014

Variations for Horner's Syndrome

Expression for Horner's Syndrome

Search GEO for disease gene expression data for Horner's Syndrome.

Pathways for Horner's Syndrome

Pathways related to Horner's Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.98 ADRA1A ADRA2A

GO Terms for Horner's Syndrome

Biological processes related to Horner's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of vasoconstriction GO:0019229 9.16 ADRA1A ADRA2A
2 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 8.96 ADRA1A ADRA2A
3 adrenergic receptor signaling pathway GO:0071875 8.62 ADRA1A ADRA2A

Molecular functions related to Horner's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adrenergic receptor activity GO:0004935 8.62 ADRA1A ADRA2A

Sources for Horner's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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