MCID: HRS011
MIFTS: 44

Horseshoe Kidney malady

Rare diseases category

Summaries for Horseshoe Kidney

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66Wikipedia, 34MalaCards
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Wikipedia:66 Horseshoe kidney, also known as ren arcuatus (in Latin), renal fusion or super kidney, is a congenital... more...

MalaCards: Horseshoe Kidney is related to wilms tumor and teratoma. An important gene associated with Horseshoe Kidney is CDX2 (caudal type homeobox 2), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Regulation of Hypoxia-inducible Factor (HIF) by Oxygen. The compounds sampatrilat and happ have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and pancreas, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Classifications for Horseshoe Kidney

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44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

horseshoe kidney 44


Related Diseases for Horseshoe Kidney

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Horseshoe Kidney via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1wilms tumor30.7MME, REN, ACTC1, CALB2, KRT7, ENO2
2teratoma30.5ACTC1, KRT7, ENO2
3transitional cell carcinoma30.5CA9, CALB2, KRT7, KRT20, ENO2
4neurofibromatosis30.4ENO2, TSC2
5angiomyolipoma30.4TSC2, ACTC1
6neuroendocrine tumor30.3SYP, KRT20, ENO2, CDX2
7kidney cancer30.2KRT7, HNF1B, CA9
8cystadenoma30.2MME, KRT7
9adrenocortical carcinoma30.1CALB2, SYP
10cholangiocarcinoma30.1MME, KRT7, KRT20, CDX2
11adenocarcinoma30.1CDX2, ENO2, KRT20, KRT7, HNF1B, CALB2
12medulloblastoma30.1ENO2, SYP, ACTC1
13aneurysm11.0
14aortic aneurysm10.9
15abdominal aortic aneurysm10.9
16renal cell carcinoma10.7
17hydronephrosis10.6
18pyelonephritis10.4
19ureterocele10.4
20hypertension10.4
21turner syndrome10.4
22renovascular hypertension10.3
23glomerulonephritis10.3
24renal dysplasia10.3
25xanthogranulomatous pyelonephritis10.2
26nephroblastoma10.2
27nephrotic syndrome10.2
28thrombocytopenia10.2
29germ cell tumors10.2
30erythrocytosis10.2
31unilateral renal dysplasia10.2
32medulloepithelioma10.1SYP
33melanotic neuroectodermal tumor10.1SYP
34adenofibroma10.1CALB2
35inverted papilloma10.1KRT20
36adenomatoid tumor10.1CALB2
37metanephric adenoma10.1KRT7
38hemosiderosis10.1EPO
39perivascular epithelioid cell tumor10.1TSC2
40kidney rhabdoid cancer10.1TSC2
41rhabdoid tumor10.1ACTC1, SYP
42adenosarcoma10.1MME, ACTC1
43spindle cell sarcoma10.1ACTC1, KRT7
44glomus tumor10.1ACTC1, SYP
45oxyphilic adenoma10.1CA9, KRT7
46meningioma10.1CALB2, SYP
47fibroma10.1ACTC1, CALB2
48angiosarcoma10.1CALB2, ACTC1
49sertoli-leydig cell tumor10.1CALB2, KRT7
50mammary paget's disease10.1KRT7, KRT20

Graphical network of the top 20 diseases related to Horseshoe Kidney:



Diseases related to horseshoe kidney

Symptoms for Horseshoe Kidney

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Drugs & Therapeutics for Horseshoe Kidney

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Horseshoe Kidney

Drug clinical trials:

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Search NIH Clinical Center for Horseshoe Kidney

Search CenterWatch for Horseshoe Kidney

Genetic Tests for Horseshoe Kidney

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Anatomical Context for Horseshoe Kidney

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34MalaCards
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MalaCards organs/tissues related to Horseshoe Kidney:

34
Kidney, Bone, Pancreas, Colon, Lung, Thyroid, Prostate, Testis

Animal Models for Horseshoe Kidney or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Horseshoe Kidney:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.1TSC2, REN, ACTC1, CA9, HNF1B, CDX2
2MP:00053767.9EPO, MME, TSC2, REN, ACTC1, HNF1B
3MP:00028737.9CDX2, EPO, TSC2, REN, ACTC1, SYP

Publications for Horseshoe Kidney

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53PubMed
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Articles related to Horseshoe Kidney:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
A horseshoe kidney from a live donor as a renal transplant: case report. (23431980)
2013
2
Anomalous inferior vena cava associated with horseshoe kidney on multidetector computed tomography. (23849103)
2013
3
Laparoscopic Anderson-Hynes pyeloplasty without symphysiotomy for hydronephrosis with horseshoe kidney. (23710906)
2013
4
Renal cell carcinoma in a horseshoe kidney: radiology and pathology correlation. (23814684)
2013
5
Giant renal calculus in a horseshoe kidney presenting as an abdominal lump. (21249492)
2011
6
Percutaneous endovascular repair of abdominal aortic aneurysm with coexisting horseshoe kidney: technical aspects and review of the literature. (23204827)
2011
7
Venous anomalies and horseshoe kidney. A minefield in open vascular surgery. (22067928)
2011
8
Horseshoe kidney with cysts and a single ureter: a case report. (21541456)
2010
9
Ureteropelvic junction obstruction and calyceal diverticulum in a child with Turner syndrome and horseshoe kidney. (20843761)
2010
10
Renal cell carcinoma in a horseshoe kidney. (19504996)
2009
11
Drainage characteristics and differential function of the horseshoe kidney: what is typical? (18484886)
2008
12
Neurofibromatosis type 1 with intracranial hemorrhage and horseshoe kidney. (18805374)
2008
13
Aortoiliac occlusive disease in the presence of a horseshoe kidney: a case report. (18055167)
2008
14
Laparoscopic partial nephrectomy for tumour excision in a horseshoe kidney: part II. (17494112)
2007
15
Optimal scintigraphic evaluation of a hydronephrotic horseshoe kidney. (18055697)
2007
16
Split technique in horseshoe kidney transplantation. (16825807)
2006
17
Diagnostic and treatment of renovascular hypertension in the patient with horseshoe kidney]. (15909888)
2005
18
Malignant tumours in a horseshoe kidney in children: a diagnostic dilemma. (15795828)
2005
19
Morphological observation of the horseshoe kidney with special reference to the vascular system in 2 Japanese cadavers. (16350421)
2005
20
Abdominal aortic surgery and horseshoe kidney. (15599631)
2004
21
The 99mTc-DMSA renal scan and 99mTc-DTPA diuretic renogram in children and adolescents with incidental diagnosis of horseshoe kidney. (12717069)
2003
22
Ruptured abdominal aortic aneurysm complicated by horseshoe kidney and renal cell carcinoma. (12475681)
2002
23
A horseshoe kidney detected incidentally by Tc-99m DISIDA hepatobiliary scintigraphy. (11139064)
2001
24
Management of colonic perforation during percutaneous nephrolithotomy in horseshoe kidney. (11789981)
2001
25
Use of horseshoe kidney as renal transplant from living donor: its surgical feasibility and pitfalls. (11119848)
2000
26
Sonographic features of horseshoe kidney: review of 34 patients. (10625187)
2000
27
Laparoscopic heminephrectomy of a horseshoe kidney using microwave coagulator. (10210397)
1999
28
Endovascular repair of aortic aneurysms in the the presence of a horseshoe kidney. (9761585)
1998
29
A case of horseshoe kidney. (9255060)
1997
30
Special considerations in endopyelotomy in a horseshoe kidney. (8638374)
1996
31
Renal autotransplantation after horseshoe kidney injury: a case report and literature review. (8614094)
1996
32
Unilateral multicystic dysplasia in 1 component of a horseshoe kidney: case reports and review of the literature. (7933205)
1994
33
Tumor in the horseshoe kidney: clinical implications and review of embryogenesis. (1552596)
1992
34
Antenatal diagnosis of horseshoe kidney. (1608088)
1992
35
Abdominal aortic aneurysm in association with horseshoe kidney. (1765712)
1991
36
Fatty Wilms' tumor simulating teratoma; occurrence in a child with horseshoe kidney. (2845342)
1988
37
Aortic surgery and horseshoe kidney: a challenging surgical problem. (3664411)
1987
38
Horseshoe kidney in children. (3756400)
1986
39
An unusual case of Wilms' tumour in a horseshoe kidney. (3008464)
1986
40
Abdominal aortic surgery & horseshoe kidney. (3807096)
1986
41
Primary renal actinomycosis in the presence of horseshoe kidney. (3779366)
1986
42
Unilateral duplex horseshoe kidney with ectopic ureterocele. (3883510)
1985
43
Horseshoe kidney with retrocaval ureter. (3987751)
1985
44
The radionuclide diagnosis of horseshoe kidney. (3000677)
1985
45
Ruptured abdominal aortic aneurysm with horseshoe kidney. (6502842)
1984
46
Horseshoe kidney mimicking adenopathy. (6612914)
1983
47
Abdominal aortic aneurysm and horseshoe kidney. A different perspective. (454180)
1979
48
Abdominal aortic surgery in the presence of a horseshoe kidney. (666380)
1978
49
Complications of horseshoe kidney. (1162813)
1975
50
Multilocular cystic dysplasia of half of a horseshoe kidney. (4844002)
1974

Variations for Horseshoe Kidney

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Expression for genes affiliated with Horseshoe Kidney

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Horseshoe Kidney

Search GEO for disease gene expression data for Horseshoe Kidney.

Pathways for genes affiliated with Horseshoe Kidney

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Sources:
51PathCards, 52PharmGKB, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 5Cell Signaling Technology
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Compounds for genes affiliated with Horseshoe Kidney

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Horseshoe Kidney according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1sampatrilat4610.2REN, MME
2happ4610.2MME, SYP
3cilazapril46 1211.0MME, REN
4smcc4610.0SYP, ENO2
5omapatrilat4610.0REN, MME
6metanephrine46 2510.9ENO2, REN
7fosinopril46 1210.9REN, MME
8pimonidazole469.9EPO, CA9
9fludrocortisone46 30 1211.8EPO, REN
10s 100469.8ACTC1, SYP, ENO2
11enalapril46 52 1211.8REN, EPO, MME
12vanillylmandelic acid46 2510.6REN, ENO2
13octreotide46 62 30 1212.6ENO2, MME, EPO
14enalaprilat469.5MME, REN
15catecholamine469.5ENO2, SYP, REN
16reticulin469.5KRT7, ACTC1, SYP
17silver469.4CALB2, ENO2, SYP
18acth469.4REN, SYP, ENO2, MME
19potassium46 25 1211.2MME, ENO2, REN, SYP
205-hydroxytryptamine469.2MME, SYP, CALB2, ENO2
21forskolin46 52 1211.2ENO2, SYP, MME, REN
22chloride469.2MME, REN, ENO2, CA9
23acetylcholine46 52 30 25 1213.1MME, SYP, ENO2, CALB2
24ribonucleic acid469.1ENO2, KRT20, ACTC1, MME
25dexamethasone46 52 30 1212.1ACTC1, SYP, REN, MME, ENO2
265-aza-2deoxycytidine468.9CA9, CDX2, EPO, KRT7
27dopamine46 30 25 1211.9MME, SYP, CALB2, REN, ENO2
28thymidine46 259.8CDX2, EPO, CALB2, MME, ENO2
29nitric oxide46 25 1210.7SYP, REN, CALB2, ENO2, MME
30creatinine468.7SYP, EPO, MME, REN, ACTC1, ENO2
31sialic acid468.7EPO, KRT7, ENO2
32lactate468.7EPO, ENO2, CA9, MME
33arginine468.6KRT7, HNF1B, TSC2, REN, MME
34glycogen46 259.6KRT7, ENO2, ACTC1, SYP, TSC2
35steroid468.5MME, TSC2, ACTC1, SYP, CDX2, CALB2
36oxygen46 259.5EPO, MME, TSC2, ACTC1, CA9, ENO2
37mucicarmine468.4ACTC1, SYP, CALB2, KRT7, KRT20
38b 723468.4KRT7, CALB2, SYP, ACTC1, KRT20
39formaldehyde46 259.4ACTC1, SYP, KRT7, ENO2, KRT20
40retinoic acid46 259.3ACTC1, KRT7, HNF1B, ENO2, SYP, MME
41iron46 259.2ENO2, EPO, KRT20, ACTC1, KRT7
42calcium46 52 25 1210.9CDX2, ACTC1, MME, REN, SYP, CA9
43hematoxylin467.9KRT20, KRT7, CALB2, SYP, ACTC1, ENO2
44glucose467.5HNF1B, CA9, ACTC1, MME, ENO2, TSC2
45progesterone46 30 62 25 1210.8MME, ACTC1, SYP, CA9, KRT20, CALB2
46testosterone46 62 25 129.8EPO, MME, TSC2, ACTC1, SYP, CALB2
47vegf466.5ENO2, EPO, CA9, KRT7, KRT20, ACTC1
48paraffin466.5CALB2, ENO2, KRT20, KRT7, CA9, SYP
49estrogen466.5ENO2, KRT20, KRT7, CALB2, CA9, ACTC1
50tyrosine466.0ACTC1, CALB2, CDX2, ENO2, KRT20, KRT7

GO Terms for genes affiliated with Horseshoe Kidney

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17Gene Ontology
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Cellular components related to Horseshoe Kidney according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projection terminusGO:0443069.9SYP, MME

Biological processes related to Horseshoe Kidney according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:0504359.8REN, MME
2angiotensin maturationGO:0020039.7MME, REN
3regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.6CA9, EPO
4kidney developmentGO:0018229.6HNF1B, REN, MME
5response to testosteroneGO:0335749.3CA9, EPO

Products for genes affiliated with Horseshoe Kidney

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Sources for Horseshoe Kidney

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet