MCID: HRS011
MIFTS: 39

Horseshoe Kidney malady

Summaries for Horseshoe Kidney

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Horseshoe kidney, also known as ren arcuatus (in Latin), renal fusion or super kidney, is a congenital... more...

MalaCards: Horseshoe Kidney is related to wilms tumor and transitional cell carcinoma. An important gene associated with Horseshoe Kidney is CDX2 (caudal type homeobox 2), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Renin-angiotensin system. The compounds estrogen and cilazapril have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and small intestine, and related mouse phenotype normal.

Aliases & Classifications for Horseshoe Kidney

Sources:
43NIH Rare Diseases
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Aliases & Descriptions:

horseshoe kidney 43


Related Diseases for Horseshoe Kidney

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Horseshoe Kidney via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 192)
idRelated DiseaseScoreTop Affiliating Genes
1wilms tumor30.8CALB2, REN, KRT7, ACTC1, MME, ENO2
2transitional cell carcinoma30.6CALB2, ENO2, KRT20, CA9, KRT7
3squamous cell carcinoma30.6KRT7, SYP, ACTC1, CA9, ENO2, KRT20
4teratoma30.5ACTC1, KRT7, ENO2
5adenocarcinoma30.4SYP, HNF1B, ACTC1, TSC2, ENO2, CA9
6angiomyolipoma30.2ACTC1, TSC2
7bladder carcinoma30.0KRT20
8cystadenoma30.0KRT7, MME
9tuberous sclerosis30.0TSC2, SYP
10large cell carcinoma30.0SYP, ENO2, KRT7, KRT20
11renal clear cell carcinoma30.0MME, CA9, KRT7, CALB2
12papillary carcinoma30.0KRT20, CALB2, SYP, ACTC1, KRT7
13aortic aneurysm10.9
14abdominal aortic aneurysm10.9
15kid syndrome10.6
16hydronephrosis10.6
17ruptured abdominal aortic aneurysm10.5
18turner syndrome10.4
19ureterocele10.3
20neurofibromatosis10.3
21renovascular hypertension10.3
22renal dysplasia10.3
23xanthogranulomatous pyelonephritis10.2
24acute pyelonephritis10.2
25renal pelvis squamous cell carcinoma10.2
26n syndrome10.2
27aortic disease10.2
28thrombocytopenia10.2
29corpus callosum agenesis10.2
30erythrocytosis10.2
31unilateral renal dysplasia10.2
32silver-russell syndrome10.0
33thrombocytopenia-absent radius syndrome10.0
34membranous glomerulonephritis10.0
35dyskeratosis congenita10.0
36papillary cystadenocarcinoma10.0
37papillary renal cell carcinoma10.0
38somatostatinoma10.0
39kidney liposarcoma10.0
40pancytopenia10.0
41polydactyly10.0
42nephrolithiasis10.0
43focal dermal hypoplasia10.0
44actinomycosis10.0
45situs inversus10.0
46kidney hypertrophy10.0
47vesicoureteral reflux10.0
48imperforate anus10.0
49varicocele10.0
50kidney lipoma10.0

Graphical network of the top 20 diseases related to Horseshoe Kidney:



Diseases related to horseshoe kidney

Clinical Features for Horseshoe Kidney

Drugs & Therapeutics for Horseshoe Kidney

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Horseshoe Kidney

Drug clinical trials:

Search ClinicalTrials for Horseshoe Kidney

Search NIH Clinical Center for Horseshoe Kidney

Search CenterWatch for Horseshoe Kidney

Genetic Tests for Horseshoe Kidney

Anatomical Context for Horseshoe Kidney

Sources:
33MalaCards
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MalaCards organs/tissues related to Horseshoe Kidney:

33
Kidney, Lung, Small intestine, Colon, Pancreas, Thyroid, Prostate, Testis, Fetal lung, Fetal thyroid, Testis germ

Animal Models for Horseshoe Kidney or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Horseshoe Kidney:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.0TSC2, ACTC1, REN, EPO, CDX2, SYP

Publications for Horseshoe Kidney

Sources:
51PubMed
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Articles related to Horseshoe Kidney:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Horseshoe kidney for transplantation: technical considerations. (22835080)
2013
2
Horseshoe kidney: a review of anatomy and pathology. (24178305)
2013
3
Associations between kidney position and surplus renal arteries in horseshoe kidney: case report and analysis. (22975743)
2012
4
Horseshoe kidney with retrocaval ureter: one case report. (22490419)
2012
5
Repair of abdominal aortic aneurysms in the presence of the horseshoe kidney. (22233614)
2011
6
Transarterial renal embolization for enlarged horseshoe kidney. (20012919)
2010
7
Tc-99m-dimercaptosuccinic acid and Tc-99m diethylenetriamine pentaacetic acid renal scan detect "reverse horseshoe kidney". (20395708)
2010
8
Successful interdisciplinary treatment of renal cell carcinoma with tumour thrombus into inferior vena cava using multimodal protocol and organ-extending R0 resection in rare horseshoe kidney and doubled right organ. (22751093)
2010
9
A case of carcinoid tumor arising from a horseshoe kidney]. (19588864)
2009
10
Aortoiliac occlusive disease in the presence of a horseshoe kidney: a case report. (18055167)
2008
11
Preoperative embolization of a tumor-bearing horseshoe kidney via both channels of a concomitant aortic dissection. (17206388)
2007
12
Quiz page. Horseshoe kidney with a double calyces on the left side and a stone on the right side. (17687808)
2007
13
Horseshoe kidney--a case report. (17593682)
2007
14
Multiorgan failure 17 years after initial stone therapy: forgotten ureteral stent in a horseshoe kidney. (17240040)
2007
15
An aberrant renal artery arising from the iliac artery imaged by three-dimensional power Doppler ultrasonography: a sign of fetal horseshoe kidney. (17323303)
2007
16
Morphological observation of the horseshoe kidney with special reference to the vascular system in 2 Japanese cadavers. (16350421)
2005
17
Horseshoe kidney with a circumcaval ureter. (15669596)
2004
18
The renal impact of aortic stent-grafting in patients with a horseshoe kidney. (15578140)
2004
19
Nephroblastoma in horseshoe kidney. (14562527)
2002
20
Morphological study of a horseshoe kidney with special reference to the vascular system. (12418094)
2002
21
A horseshoe kidney detected incidentally by Tc-99m DISIDA hepatobiliary scintigraphy. (11139064)
2001
22
Caroli's syndrome and horseshoe kidney: a case report. (11332947)
2001
23
Endovascular AAA repair in a patient with a horseshoe kidney and an isthmus mass. (11797977)
2001
24
Use of horseshoe kidney as renal transplant from living donor: its surgical feasibility and pitfalls. (11119848)
2000
25
Thrombocytopenia and absent radii (TAR) syndrome associated with horseshoe kidney. (10654326)
2000
26
Transplantation of horseshoe kidney en bloc. (11325010)
2000
27
Erythrocytosis and hydronephrosis in a horseshoe kidney]. (10589125)
1999
28
Repair of bilateral common iliac artery aneurysms coexisting with a pelvic horseshoe kidney. (10541619)
1999
29
Super-selective arterial embolization for blunt trauma in the horseshoe kidney. (9495719)
1998
30
Infected caliceal diverticulum in a horseshoe kidney. (9720571)
1998
31
Special considerations in endopyelotomy in a horseshoe kidney. (8638374)
1996
32
Isthmus hypertrophy mimics tumour in horseshoe kidney: a case report. (8713567)
1996
33
Carcinoid in a horseshoe kidney. Morphology, immunohistochemistry, and cytogenetics. (8536229)
1995
34
Glomerulocystic disease: unilateral involvement of a horseshoe kidney and in trisomy 18. (8398645)
1993
35
A case with endocardial cushion defect and horseshoe kidney. (8459892)
1993
36
Horseshoe kidney associated with left inferior vena cava. (2021832)
1991
37
Triple catheter aortoiliac angioplasty in a patient with a horseshoe kidney: technical note. (2534060)
1989
38
Horseshoe kidney simulation by paraaortic metastases from a testicular tumor. (3816005)
1987
39
Percutaneous stone removal in horseshoe kidney. (3727227)
1986
40
Ruptured abdominal aortic aneurysm with horseshoe kidney. (6502842)
1984
41
Renal cell carcinoma in a horseshoe kidney. (6727390)
1984
42
Horseshoe kidney: report of four cases clinical evaluation and management. (6680792)
1983
43
Unilateral autonephrectomization in horseshoe kidney. (7027587)
1981
44
Retroperitoneal lymphadenectomy for germ cell tumor of testis in association with horseshoe kidney. (7314333)
1981
45
Horseshoe kidney obstructing catheterisation of both umbilical arteries. (6106137)
1980
46
Renal carcinoma in a horseshoe kidney. (754853)
1978
47
Traumatic rupture of horseshoe kidney. (846024)
1977
48
Case profile: horseshoe kidney with calculi in patient with sarcoidosis. (997058)
1976
49
Ruptured aneurysm of the abdominal aorta in the presence of a horseshoe kidney. (1211948)
1975
50
Nonduplication of upper urinary tract associated with horseshoe kidney and bilateral ureteral ectopia. (1136091)
1975

Genetic Variations for Horseshoe Kidney

Expression for genes affiliated with Horseshoe Kidney

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Horseshoe Kidney

Search GEO for disease gene expression data for Horseshoe Kidney.

Pathways for genes affiliated with Horseshoe Kidney

Sources:
50PharmGKB, 38NCBI BioSystems Database, 30KEGG, 54Reactome, 4Cell Signaling Technology
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Compounds for genes affiliated with Horseshoe Kidney

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Horseshoe Kidney according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1estrogen4510.4CALB2
2cilazapril45 1111.4MME
3happ4510.2MME, SYP
4sampatrilat4510.1REN, MME
5omapatrilat4510.0REN, MME
6smcc4510.0SYP, ENO2
7fludrocortisone45 29 1111.9EPO, REN
8pimonidazole459.9CA9, EPO
9fosinopril45 1110.9REN, MME
10metanephrine45 2410.9REN, ENO2
11s 100459.8ENO2, ACTC1, SYP
12vanillylmandelic acid45 2410.8REN, ENO2
13enalapril45 50 1111.8MME, REN, EPO
14enalaprilat459.7REN, MME
15acetazolamide45 1110.6CA9, EPO
16octreotide45 60 29 1112.5EPO, MME, ENO2
17dexamethasone45 50 29 1112.5REN, MME, ENO2
18reticulin459.5KRT7, ACTC1, SYP
19catecholamine459.5SYP, REN, ENO2
20silver459.5ENO2, CALB2, SYP
21lisinopril45 11 2411.5MME, REN
22acth459.3ENO2, MME, SYP, REN
235-hydroxytryptamine459.2ENO2, CALB2, SYP, MME
24chloride459.1CA9, ENO2, MME, REN
25dopamine45 29 11 2412.1CALB2, REN, MME, ENO2
26acetylcholine45 50 29 11 2413.1CALB2, SYP, MME, ENO2
27potassium45 11 2411.1REN, MME, ENO2, SYP
28ribonucleic acid459.0MME, ACTC1, ENO2, KRT20
29forskolin45 50 1111.0REN, MME, ENO2, SYP
305-aza-2deoxycytidine458.9CDX2, EPO, KRT7, CA9
31thymidine45 249.8ENO2, CALB2, CDX2, MME, EPO
32creatinine458.7ACTC1, EPO, MME, REN, SYP, ENO2
33glycogen45 249.7KRT7, ACTC1, SYP, ENO2, TSC2
34steroid458.5ACTC1, CALB2, SYP, CDX2, REN, TSC2
35arginine458.5MME, TSC2, HNF1B, REN, KRT7
36nitric oxide45 11 2410.5MME, REN, SYP, CALB2, ENO2
37oxygen45 249.5CA9, EPO, TSC2, MME, ACTC1, ENO2
38mucicarmine458.4SYP, KRT20, KRT7, CALB2, ACTC1
39b 723458.4ACTC1, KRT7, KRT20, SYP, CALB2
40formaldehyde45 249.4ENO2, ACTC1, KRT20, KRT7, SYP
41glucose458.3HNF1B, REN, KRT7, ACTC1, TSC2, CA9
42retinoic acid45 249.3ACTC1, HNF1B, SYP, ENO2, MME, KRT7
43iron45 249.2EPO, KRT7, KRT20, ACTC1, ENO2
44hematoxylin457.9ACTC1, KRT20, KRT7, ENO2, CALB2, SYP
45calcium45 50 11 2410.8MME, ENO2, ACTC1, REN, CDX2, SYP
46progesterone45 60 29 11 2410.8MME, KRT20, ACTC1, CDX2, CALB2, SYP
47testosterone45 60 11 249.8EPO, SYP, CALB2, ACTC1, KRT20, TSC2
48paraffin456.5KRT20, TSC2, ENO2, ACTC1, KRT7, MME
49vegf456.5REN, EPO, SYP, CA9, MME, KRT20
50tyrosine456.1TSC2, ENO2, ACTC1, MME, KRT20, KRT7

GO Terms for genes affiliated with Horseshoe Kidney

Sources:
16Gene Ontology
See all sources

Cellular components related to Horseshoe Kidney according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projection terminusGO:0443069.9MME, SYP

Biological processes related to Horseshoe Kidney according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:0504359.7MME, REN
2regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.6EPO, CA9
3angiotensin maturationGO:0020039.5MME, REN
4kidney developmentGO:0018229.5MME, REN, HNF1B

Products for genes affiliated with Horseshoe Kidney

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  • Proteins
  • Lysates
  • Antibodies

Sources for Horseshoe Kidney

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet