MCID: HRS011
MIFTS: 38

Horseshoe Kidney malady

Rare diseases category

Summaries for Horseshoe Kidney

About this section


Wikipedia:63 Horseshoe kidney, also known as ren arcuatus (in Latin), renal fusion or super kidney, is a congenital... more...

MalaCards based summary: Horseshoe Kidney is related to renal cell carcinoma and kidney cancer. An important gene associated with Horseshoe Kidney is CDX2 (caudal type homeobox 2), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Regulation of Hypoxia-inducible Factor (HIF) by Oxygen. The compounds sampatrilat and happ have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and colon, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Classifications for Horseshoe Kidney

About this section

Horseshoe Kidney, Aliases & Descriptions:

Name: Horseshoe Kidney 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Horseshoe Kidney

About this section

Diseases related to Horseshoe Kidney via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1renal cell carcinoma31.5HNF1B, KRT7, CA9
2kidney cancer30.7TSC2
3cystadenoma30.7KRT7, MME
4angiomyolipoma30.7TSC2, ACTC1
5teratoma30.6ACTC1, KRT7, ENO2
6adrenocortical carcinoma30.3SYP, CALB2
7neurofibromatosis30.3ENO2, TSC2
8transitional cell carcinoma30.2KRT7, KRT20, ENO2, CALB2, CA9
9neuroendocrine tumor30.2CDX2, SYP, ENO2, KRT20
10medulloblastoma30.1ACTC1, ENO2, SYP
11wilms tumor30.1MME, ENO2, KRT7, CALB2, ACTC1, REN
12leiomyosarcoma29.9ENO2, CALB2, MME, ACTC1
13adenocarcinoma28.7MME, ACTC1, CALB2, HNF1B, KRT7, KRT20
14aneurysm11.0
15aortic aneurysm11.0
16abdominal aortic aneurysm10.9
17hydronephrosis10.6
18medulloepithelioma10.5SYP
19melanotic neuroectodermal tumor10.5SYP
20adenofibroma10.5CALB2
21inverted papilloma10.5KRT20
22adenomatoid tumor10.5CALB2
23metanephric adenoma10.5KRT7
24pyelonephritis10.4
25hemosiderosis10.4EPO
26perivascular epithelioid cell tumor10.4TSC2
27turner syndrome10.4
28rhabdoid tumor10.4ACTC1, SYP
29adenosarcoma10.4MME, ACTC1
30spindle cell sarcoma10.4KRT7, ACTC1
31ureterocele10.4
32glomus tumor10.4ACTC1, SYP
33oxyphilic adenoma10.4CA9, KRT7
34meningioma, familial10.4CALB2, SYP
35fibroma10.3CALB2, ACTC1
36angiosarcoma10.3ACTC1, CALB2
37sertoli-leydig cell tumor10.3CALB2, KRT7
38mammary paget's disease10.3KRT20, KRT7
39epithelioid sarcoma10.3CALB2, KRT7
40ovarian brenner tumor10.3KRT20, KRT7
41signet ring cell adenocarcinoma10.3KRT20, KRT7
42mucinous cystadenocarcinoma10.3KRT7, KRT20
43endometrial stromal sarcoma10.3MME, ACTC1
44paget disease, extramammary10.3KRT7, KRT20
45pancreatic ductal carcinoma10.3KRT7, KRT20
46sex cord-gonadal stromal tumor10.3CALB2, KRT7
47neurofibroma10.3ACTC1, SYP
48neurofibromatosis, type 110.3
49glomerulonephritis10.3
50renovascular hypertension10.3

Graphical network of the top 20 diseases related to Horseshoe Kidney:



Diseases related to horseshoe kidney

Symptoms for Horseshoe Kidney

About this section

Drugs & Therapeutics for Horseshoe Kidney

About this section

Drug clinical trials:

Search ClinicalTrials for Horseshoe Kidney

Search NIH Clinical Center for Horseshoe Kidney

Genetic Tests for Horseshoe Kidney

About this section

Anatomical Context for Horseshoe Kidney

About this section

MalaCards organs/tissues related to Horseshoe Kidney:

31
Kidney, Bone, Colon, Pancreas, Spleen, Lung, Thyroid, Prostate, Testis

Animal Models for Horseshoe Kidney or affiliated genes

About this section

MGI Mouse Phenotypes related to Horseshoe Kidney:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.1TSC2, REN, ACTC1, CA9, HNF1B, CDX2
2MP:00053767.9EPO, MME, TSC2, REN, ACTC1, HNF1B
3MP:00028737.9CDX2, EPO, TSC2, REN, ACTC1, SYP

Publications for Horseshoe Kidney

About this section

Articles related to Horseshoe Kidney:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Expanding the living renal donor pool by using a horseshoe kidney. (25838656)
2015
2
Mucinous cystadenoma of a horseshoe kidney: A case report and literature review. (25624964)
2015
3
Transplantation of a horseshoe kidney found during harvest operation of a cadaveric donor: a case report. (25120330)
2014
4
A horseshoe kidney from a live donor as a renal transplant: case report. (23431980)
2013
5
Anomalous inferior vena cava associated with horseshoe kidney on multidetector computed tomography. (23849103)
2013
6
Wandering spleen in an adult man associated with the horseshoe kidney. (24693523)
2013
7
Laparoscopic Anderson-Hynes pyeloplasty without symphysiotomy for hydronephrosis with horseshoe kidney. (23710906)
2013
8
Renal cell carcinoma in a horseshoe kidney: radiology and pathology correlation. (23814684)
2013
9
Giant renal calculus in a horseshoe kidney presenting as an abdominal lump. (21249492)
2011
10
Percutaneous endovascular repair of abdominal aortic aneurysm with coexisting horseshoe kidney: technical aspects and review of the literature. (23204827)
2011
11
Venous anomalies and horseshoe kidney. A minefield in open vascular surgery. (22067928)
2011
12
Renal cell carcinoma in a horseshoe kidney. (19504996)
2009
13
Drainage characteristics and differential function of the horseshoe kidney: what is typical? (18484886)
2008
14
Neurofibromatosis type 1 with intracranial hemorrhage and horseshoe kidney. (18805374)
2008
15
Aortoiliac occlusive disease in the presence of a horseshoe kidney: a case report. (18055167)
2008
16
Laparoscopic partial nephrectomy for tumour excision in a horseshoe kidney: part II. (17494112)
2007
17
Optimal scintigraphic evaluation of a hydronephrotic horseshoe kidney. (18055697)
2007
18
Diagnostic and treatment of renovascular hypertension in the patient with horseshoe kidney]. (15909888)
2005
19
Malignant tumours in a horseshoe kidney in children: a diagnostic dilemma. (15795828)
2005
20
Morphological observation of the horseshoe kidney with special reference to the vascular system in 2 Japanese cadavers. (16350421)
2005
21
Abdominal aortic surgery and horseshoe kidney. (15599631)
2004
22
The 99mTc-DMSA renal scan and 99mTc-DTPA diuretic renogram in children and adolescents with incidental diagnosis of horseshoe kidney. (12717069)
2003
23
Ruptured abdominal aortic aneurysm complicated by horseshoe kidney and renal cell carcinoma. (12475681)
2002
24
A horseshoe kidney detected incidentally by Tc-99m DISIDA hepatobiliary scintigraphy. (11139064)
2001
25
Use of horseshoe kidney as renal transplant from living donor: its surgical feasibility and pitfalls. (11119848)
2000
26
Sonographic features of horseshoe kidney: review of 34 patients. (10625187)
2000
27
Laparoscopic heminephrectomy of a horseshoe kidney using microwave coagulator. (10210397)
1999
28
Endovascular repair of aortic aneurysms in the the presence of a horseshoe kidney. (9761585)
1998
29
A case of horseshoe kidney. (9255060)
1997
30
Special considerations in endopyelotomy in a horseshoe kidney. (8638374)
1996
31
Renal autotransplantation after horseshoe kidney injury: a case report and literature review. (8614094)
1996
32
Unilateral multicystic dysplasia in 1 component of a horseshoe kidney: case reports and review of the literature. (7933205)
1994
33
Tumor in the horseshoe kidney: clinical implications and review of embryogenesis. (1552596)
1992
34
Antenatal diagnosis of horseshoe kidney. (1608088)
1992
35
Abdominal aortic aneurysm in association with horseshoe kidney. (1765712)
1991
36
Fatty Wilms' tumor simulating teratoma; occurrence in a child with horseshoe kidney. (2845342)
1988
37
Aortic surgery and horseshoe kidney: a challenging surgical problem. (3664411)
1987
38
Horseshoe kidney in children. (3756400)
1986
39
An unusual case of Wilms' tumour in a horseshoe kidney. (3008464)
1986
40
Abdominal aortic surgery & horseshoe kidney. (3807096)
1986
41
Primary renal actinomycosis in the presence of horseshoe kidney. (3779366)
1986
42
Unilateral duplex horseshoe kidney with ectopic ureterocele. (3883510)
1985
43
Horseshoe kidney with retrocaval ureter. (3987751)
1985
44
The radionuclide diagnosis of horseshoe kidney. (3000677)
1985
45
Ruptured abdominal aortic aneurysm with horseshoe kidney. (6502842)
1984
46
Horseshoe kidney mimicking adenopathy. (6612914)
1983
47
Abdominal aortic aneurysm and horseshoe kidney. A different perspective. (454180)
1979
48
Abdominal aortic surgery in the presence of a horseshoe kidney. (666380)
1978
49
Complications of horseshoe kidney. (1162813)
1975
50
Multilocular cystic dysplasia of half of a horseshoe kidney. (4844002)
1974

Variations for Horseshoe Kidney

About this section

Expression for genes affiliated with Horseshoe Kidney

About this section
Search GEO for disease gene expression data for Horseshoe Kidney.

Pathways for genes affiliated with Horseshoe Kidney

About this section

Compounds for genes affiliated with Horseshoe Kidney

About this section

Compounds related to Horseshoe Kidney according to GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1sampatrilat4310.2REN, MME
2happ4310.2MME, SYP
3cilazapril43 1211.0MME, REN
4smcc4310.0SYP, ENO2
5omapatrilat4310.0REN, MME
6metanephrine43 2410.9ENO2, REN
7fosinopril43 1210.9REN, MME
8pimonidazole439.9EPO, CA9
9fludrocortisone43 28 1211.8EPO, REN
10s 100439.8ACTC1, SYP, ENO2
11enalapril43 49 1211.8REN, EPO, MME
12vanillylmandelic acid43 2410.6REN, ENO2
13octreotide43 59 28 1212.6ENO2, MME, EPO
14enalaprilat439.5MME, REN
15catecholamine439.5ENO2, SYP, REN
16reticulin439.5KRT7, ACTC1, SYP
17silver439.4CALB2, ENO2, SYP
18acth439.4REN, SYP, ENO2, MME
19potassium43 24 1211.2MME, ENO2, REN, SYP
205-hydroxytryptamine439.2MME, SYP, CALB2, ENO2
21forskolin43 49 1211.2ENO2, SYP, MME, REN
22chloride439.2MME, REN, ENO2, CA9
23acetylcholine43 49 28 24 1213.1MME, SYP, ENO2, CALB2
24ribonucleic acid439.1ENO2, KRT20, ACTC1, MME
25dexamethasone43 49 28 1212.1ACTC1, SYP, REN, MME, ENO2
265-aza-2deoxycytidine438.9CA9, CDX2, EPO, KRT7
27dopamine43 28 24 1211.9MME, SYP, CALB2, REN, ENO2
28thymidine43 249.8CDX2, EPO, CALB2, MME, ENO2
29nitric oxide43 24 1210.7SYP, REN, CALB2, ENO2, MME
30creatinine438.7SYP, EPO, MME, REN, ACTC1, ENO2
31sialic acid438.7EPO, KRT7, ENO2
32lactate438.7EPO, ENO2, CA9, MME
33arginine438.6KRT7, HNF1B, TSC2, REN, MME
34glycogen43 249.6KRT7, ENO2, ACTC1, SYP, TSC2
35steroid438.5MME, TSC2, ACTC1, SYP, CDX2, CALB2
36oxygen43 249.5EPO, MME, TSC2, ACTC1, CA9, ENO2
37mucicarmine438.4ACTC1, SYP, CALB2, KRT7, KRT20
38b 723438.4KRT7, CALB2, SYP, ACTC1, KRT20
39formaldehyde43 249.4ACTC1, SYP, KRT7, ENO2, KRT20
40retinoic acid43 249.3ACTC1, KRT7, HNF1B, ENO2, SYP, MME
41iron43 249.2ENO2, EPO, KRT20, ACTC1, KRT7
42calcium43 49 24 1210.9CDX2, ACTC1, MME, REN, SYP, CA9
43hematoxylin437.9KRT20, KRT7, CALB2, SYP, ACTC1, ENO2
44glucose437.5HNF1B, CA9, ACTC1, MME, ENO2, TSC2
45progesterone43 28 59 24 1210.8MME, ACTC1, SYP, CA9, KRT20, CALB2
46testosterone43 59 24 129.8EPO, MME, TSC2, ACTC1, SYP, CALB2
47vegf436.5ENO2, EPO, CA9, KRT7, KRT20, ACTC1
48paraffin436.5CALB2, ENO2, KRT20, KRT7, CA9, SYP
49estrogen436.5ENO2, KRT20, KRT7, CALB2, CA9, ACTC1
50tyrosine436.0ACTC1, CALB2, CDX2, ENO2, KRT20, KRT7

GO Terms for genes affiliated with Horseshoe Kidney

About this section

Cellular components related to Horseshoe Kidney according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuron projection terminusGO:00443069.9SYP, MME

Biological processes related to Horseshoe Kidney according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:00504359.8MME, REN
2angiotensin maturationGO:00020039.7REN, MME
3regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:00614189.6CA9, EPO
4kidney developmentGO:00018229.6HNF1B, REN, MME
5response to testosteroneGO:00335749.3EPO, CA9

Products for genes affiliated with Horseshoe Kidney

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Horseshoe Kidney

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet