MCID: HRS011
MIFTS: 45

Horseshoe Kidney malady

Rare diseases category
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Summaries for Horseshoe Kidney

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Wikipedia:65 Horseshoe kidney, also known as ren arcuatus (in Latin), renal fusion or super kidney, is a congenital... more...

MalaCards based summary: Horseshoe Kidney is related to angiomyolipoma and teratoma. An important gene associated with Horseshoe Kidney is CDX2 (caudal type homeobox 2), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Regulation of Hypoxia-inducible Factor (HIF) by Oxygen. The compounds sampatrilat and happ have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and colon, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Classifications for Horseshoe Kidney

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Horseshoe Kidney, Aliases & Descriptions:

Name: Horseshoe Kidney 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Horseshoe Kidney

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Diseases related to Horseshoe Kidney via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1angiomyolipoma30.7TSC2, ACTC1
2teratoma30.6ACTC1, KRT7, ENO2
3kidney cancer30.5HNF1B, KRT7, CA9
4cystadenoma30.5KRT7, MME
5adrenocortical carcinoma30.4SYP, CALB2
6neurofibromatosis30.3ENO2, TSC2
7transitional cell carcinoma30.2KRT7, KRT20, ENO2, CALB2, CA9
8neuroendocrine tumor30.2CDX2, SYP, ENO2, KRT20
9cholangiocarcinoma30.2CDX2, KRT20, KRT7, MME
10medulloblastoma30.1ACTC1, ENO2, SYP
11wilms tumor30.1MME, ENO2, KRT7, CALB2, ACTC1, REN
12leiomyosarcoma29.9ENO2, CALB2, MME, ACTC1
13adenocarcinoma28.7MME, ACTC1, CALB2, HNF1B, KRT7, KRT20
14aneurysm11.0
15aortic aneurysm11.0
16abdominal aortic aneurysm10.9
17renal cell carcinoma10.7
18hydronephrosis10.6
19medulloepithelioma10.5SYP
20melanotic neuroectodermal tumor10.5SYP
21adenofibroma10.5CALB2
22inverted papilloma10.5KRT20
23adenomatoid tumor10.5CALB2
24metanephric adenoma10.5KRT7
25pyelonephritis10.5
26hemosiderosis10.4EPO
27perivascular epithelioid cell tumor10.4TSC2
28kidney rhabdoid cancer10.4TSC2
29turner syndrome10.4
30rhabdoid tumor10.4ACTC1, SYP
31adenosarcoma10.4MME, ACTC1
32spindle cell sarcoma10.4KRT7, ACTC1
33oxyphilic adenoma10.4CA9, KRT7
34hypertension10.4
35ureterocele10.4
36meningioma10.4CALB2, SYP
37fibroma10.4CALB2, ACTC1
38angiosarcoma10.3ACTC1, CALB2
39sertoli-leydig cell tumor10.3CALB2, KRT7
40mammary paget's disease10.3KRT20, KRT7
41epithelioid sarcoma10.3CALB2, KRT7
42ovarian brenner tumor10.3KRT20, KRT7
43signet ring cell adenocarcinoma10.3KRT20, KRT7
44mucinous cystadenocarcinoma10.3KRT7, KRT20
45endometrial stromal sarcoma10.3MME, ACTC1
46cutaneous paget's disease10.3KRT7, KRT20
47pancreatic ductal carcinoma10.3KRT7, KRT20
48neurofibroma10.3ACTC1, SYP
49sex cord-gonadal stromal tumor10.3CALB2, KRT7
50glomerulonephritis10.3

Graphical network of the top 20 diseases related to Horseshoe Kidney:



Diseases related to horseshoe kidney

Symptoms for Horseshoe Kidney

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Drugs & Therapeutics for Horseshoe Kidney

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Drug clinical trials:

Search ClinicalTrials for Horseshoe Kidney

Search NIH Clinical Center for Horseshoe Kidney

Genetic Tests for Horseshoe Kidney

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Anatomical Context for Horseshoe Kidney

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MalaCards organs/tissues related to Horseshoe Kidney:

32
Kidney, Bone, Colon, Pancreas, Spleen, Lung, Thyroid, Prostate, Testis

Animal Models for Horseshoe Kidney or affiliated genes

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MGI Mouse Phenotypes related to Horseshoe Kidney:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.1TSC2, REN, ACTC1, CA9, HNF1B, CDX2
2MP:00053767.9EPO, MME, TSC2, REN, ACTC1, HNF1B
3MP:00028737.9CDX2, EPO, TSC2, REN, ACTC1, SYP

Publications for Horseshoe Kidney

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Articles related to Horseshoe Kidney:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Transplantation of a horseshoe kidney found during harvest operation of a cadaveric donor: a case report. (25120330)
2014
2
A horseshoe kidney from a live donor as a renal transplant: case report. (23431980)
2013
3
Anomalous inferior vena cava associated with horseshoe kidney on multidetector computed tomography. (23849103)
2013
4
Wandering spleen in an adult man associated with the horseshoe kidney. (24693523)
2013
5
Laparoscopic Anderson-Hynes pyeloplasty without symphysiotomy for hydronephrosis with horseshoe kidney. (23710906)
2013
6
Renal cell carcinoma in a horseshoe kidney: radiology and pathology correlation. (23814684)
2013
7
Giant renal calculus in a horseshoe kidney presenting as an abdominal lump. (21249492)
2011
8
Percutaneous endovascular repair of abdominal aortic aneurysm with coexisting horseshoe kidney: technical aspects and review of the literature. (23204827)
2011
9
Horseshoe kidney with cysts and a single ureter: a case report. (21541456)
2010
10
Ureteropelvic junction obstruction and calyceal diverticulum in a child with Turner syndrome and horseshoe kidney. (20843761)
2010
11
Renal cell carcinoma in a horseshoe kidney. (19504996)
2009
12
Drainage characteristics and differential function of the horseshoe kidney: what is typical? (18484886)
2008
13
Neurofibromatosis type 1 with intracranial hemorrhage and horseshoe kidney. (18805374)
2008
14
Aortoiliac occlusive disease in the presence of a horseshoe kidney: a case report. (18055167)
2008
15
Laparoscopic partial nephrectomy for tumour excision in a horseshoe kidney: part II. (17494112)
2007
16
Optimal scintigraphic evaluation of a hydronephrotic horseshoe kidney. (18055697)
2007
17
Diagnostic and treatment of renovascular hypertension in the patient with horseshoe kidney]. (15909888)
2005
18
Malignant tumours in a horseshoe kidney in children: a diagnostic dilemma. (15795828)
2005
19
Morphological observation of the horseshoe kidney with special reference to the vascular system in 2 Japanese cadavers. (16350421)
2005
20
Abdominal aortic surgery and horseshoe kidney. (15599631)
2004
21
The 99mTc-DMSA renal scan and 99mTc-DTPA diuretic renogram in children and adolescents with incidental diagnosis of horseshoe kidney. (12717069)
2003
22
Ruptured abdominal aortic aneurysm complicated by horseshoe kidney and renal cell carcinoma. (12475681)
2002
23
A horseshoe kidney detected incidentally by Tc-99m DISIDA hepatobiliary scintigraphy. (11139064)
2001
24
Management of colonic perforation during percutaneous nephrolithotomy in horseshoe kidney. (11789981)
2001
25
Use of horseshoe kidney as renal transplant from living donor: its surgical feasibility and pitfalls. (11119848)
2000
26
Sonographic features of horseshoe kidney: review of 34 patients. (10625187)
2000
27
Laparoscopic heminephrectomy of a horseshoe kidney using microwave coagulator. (10210397)
1999
28
Endovascular repair of aortic aneurysms in the the presence of a horseshoe kidney. (9761585)
1998
29
A case of horseshoe kidney. (9255060)
1997
30
Special considerations in endopyelotomy in a horseshoe kidney. (8638374)
1996
31
Renal autotransplantation after horseshoe kidney injury: a case report and literature review. (8614094)
1996
32
Unilateral multicystic dysplasia in 1 component of a horseshoe kidney: case reports and review of the literature. (7933205)
1994
33
Tumor in the horseshoe kidney: clinical implications and review of embryogenesis. (1552596)
1992
34
Antenatal diagnosis of horseshoe kidney. (1608088)
1992
35
Abdominal aortic aneurysm in association with horseshoe kidney. (1765712)
1991
36
Fatty Wilms' tumor simulating teratoma; occurrence in a child with horseshoe kidney. (2845342)
1988
37
Aortic surgery and horseshoe kidney: a challenging surgical problem. (3664411)
1987
38
Horseshoe kidney in children. (3756400)
1986
39
An unusual case of Wilms' tumour in a horseshoe kidney. (3008464)
1986
40
Abdominal aortic surgery & horseshoe kidney. (3807096)
1986
41
Primary renal actinomycosis in the presence of horseshoe kidney. (3779366)
1986
42
Unilateral duplex horseshoe kidney with ectopic ureterocele. (3883510)
1985
43
Horseshoe kidney with retrocaval ureter. (3987751)
1985
44
The radionuclide diagnosis of horseshoe kidney. (3000677)
1985
45
Ruptured abdominal aortic aneurysm with horseshoe kidney. (6502842)
1984
46
Horseshoe kidney mimicking adenopathy. (6612914)
1983
47
Adenocarcinoma of the pelvis of a horseshoe kidney. (7426954)
1980
48
Abdominal aortic aneurysm and horseshoe kidney. A different perspective. (454180)
1979
49
Abdominal aortic surgery in the presence of a horseshoe kidney. (666380)
1978
50
Multilocular cystic dysplasia of half of a horseshoe kidney. (4844002)
1974

Variations for Horseshoe Kidney

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Expression for genes affiliated with Horseshoe Kidney

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Expression patterns in normal tissues for genes affiliated with Horseshoe Kidney

Search GEO for disease gene expression data for Horseshoe Kidney.

Pathways for genes affiliated with Horseshoe Kidney

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Compounds for genes affiliated with Horseshoe Kidney

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Compounds related to Horseshoe Kidney according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1sampatrilat4410.2REN, MME
2happ4410.2MME, SYP
3cilazapril44 1111.0MME, REN
4smcc4410.0SYP, ENO2
5omapatrilat4410.0REN, MME
6metanephrine44 2410.9ENO2, REN
7fosinopril44 1110.9REN, MME
8pimonidazole449.9EPO, CA9
9fludrocortisone44 28 1111.8EPO, REN
10s 100449.8ACTC1, SYP, ENO2
11enalapril44 50 1111.8REN, EPO, MME
12vanillylmandelic acid44 2410.6REN, ENO2
13octreotide44 61 28 1112.6ENO2, MME, EPO
14enalaprilat449.5MME, REN
15catecholamine449.5ENO2, SYP, REN
16reticulin449.5KRT7, ACTC1, SYP
17silver449.4CALB2, ENO2, SYP
18acth449.4REN, SYP, ENO2, MME
19potassium44 24 1111.2MME, ENO2, REN, SYP
205-hydroxytryptamine449.2MME, SYP, CALB2, ENO2
21forskolin44 50 1111.2ENO2, SYP, MME, REN
22chloride449.2MME, REN, ENO2, CA9
23acetylcholine44 50 28 24 1113.1MME, SYP, ENO2, CALB2
24ribonucleic acid449.1ENO2, KRT20, ACTC1, MME
25dexamethasone44 50 28 1112.1ACTC1, SYP, REN, MME, ENO2
265-aza-2deoxycytidine448.9CA9, CDX2, EPO, KRT7
27dopamine44 28 24 1111.9MME, SYP, CALB2, REN, ENO2
28thymidine44 249.8CDX2, EPO, CALB2, MME, ENO2
29nitric oxide44 24 1110.7SYP, REN, CALB2, ENO2, MME
30creatinine448.7SYP, EPO, MME, REN, ACTC1, ENO2
31sialic acid448.7EPO, KRT7, ENO2
32lactate448.7EPO, ENO2, CA9, MME
33arginine448.6KRT7, HNF1B, TSC2, REN, MME
34glycogen44 249.6KRT7, ENO2, ACTC1, SYP, TSC2
35steroid448.5MME, TSC2, ACTC1, SYP, CDX2, CALB2
36oxygen44 249.5EPO, MME, TSC2, ACTC1, CA9, ENO2
37mucicarmine448.4ACTC1, SYP, CALB2, KRT7, KRT20
38b 723448.4KRT7, CALB2, SYP, ACTC1, KRT20
39formaldehyde44 249.4ACTC1, SYP, KRT7, ENO2, KRT20
40retinoic acid44 249.3ACTC1, KRT7, HNF1B, ENO2, SYP, MME
41iron44 249.2ENO2, EPO, KRT20, ACTC1, KRT7
42calcium44 50 24 1110.9CDX2, ACTC1, MME, REN, SYP, CA9
43hematoxylin447.9KRT20, KRT7, CALB2, SYP, ACTC1, ENO2
44glucose447.5HNF1B, CA9, ACTC1, MME, ENO2, TSC2
45progesterone44 28 61 24 1110.8MME, ACTC1, SYP, CA9, KRT20, CALB2
46testosterone44 61 24 119.8EPO, MME, TSC2, ACTC1, SYP, CALB2
47vegf446.5ENO2, EPO, CA9, KRT7, KRT20, ACTC1
48paraffin446.5CALB2, ENO2, KRT20, KRT7, CA9, SYP
49estrogen446.5ENO2, KRT20, KRT7, CALB2, CA9, ACTC1
50tyrosine446.0ACTC1, CALB2, CDX2, ENO2, KRT20, KRT7

GO Terms for genes affiliated with Horseshoe Kidney

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Cellular components related to Horseshoe Kidney according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projection terminusGO:0443069.9SYP, MME

Biological processes related to Horseshoe Kidney according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:0504359.8REN, MME
2angiotensin maturationGO:0020039.7MME, REN
3regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.6CA9, EPO
4kidney developmentGO:0018229.6HNF1B, REN, MME
5response to testosteroneGO:0335749.3CA9, EPO

Products for genes affiliated with Horseshoe Kidney

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Sources for Horseshoe Kidney

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet