MCID: HRS011
MIFTS: 28

Horseshoe Kidney malady

Summaries for Horseshoe Kidney

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63Wikipedia, 32MalaCards
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Wikipedia:63 Horseshoe kidney, also known as ren arcuatus (in Latin), renal fusion or super kidney, is a congenital... more...

MalaCards: Horseshoe Kidney is related to transitional cell carcinoma and squamous cell carcinoma. An important gene associated with Horseshoe Kidney is CDX2 (caudal type homeobox 2), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Renin-angiotensin system. The compounds estrogen and cilazapril have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotype normal.

Aliases & Classifications for Horseshoe Kidney

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42NIH Rare Diseases
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Aliases & Descriptions:

horseshoe kidney 42


Related Diseases for Horseshoe Kidney

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17GeneCards, 18GeneDecks
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Diseases related to Horseshoe Kidney via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1transitional cell carcinoma30.5CALB2, CA9, KRT7, KRT20, ENO2
2squamous cell carcinoma30.5CALB2, CA9, SYP, CDX2, KRT7, KRT20
3adenocarcinoma30.4HNF1B, CALB2, CA9, SYP, CDX2, MME
4cystic kidney30.3HNF1B, TSC2
5angiomyolipoma30.2ACTC1, TSC2
6neuroendocrine tumor30.2SYP, CDX2, KRT20, ENO2
7hemangioma30.0ACTC1
8bladder carcinoma30.0KRT20
9cystadenoma30.0MME, KRT7
10kidney cancer30.0HNF1B, CA9, KRT7
11tuberous sclerosis30.0TSC2, SYP
12seminoma30.0ENO2, CALB2
13medulloblastoma30.0ENO2, ACTC1, SYP
14large cell carcinoma30.0ENO2, KRT20, KRT7, SYP
15renal clear cell carcinoma30.0KRT7, MME, CA9, CALB2
16papillary carcinoma30.0CALB2, SYP, KRT7, KRT20, ACTC1
17aortic aneurysm10.9
18abdominal aortic aneurysm10.9
19renal cell carcinoma10.7
20hydronephrosis10.5
21ruptured aortic aneurysm10.5
22kidney disease10.5
23ruptured abdominal aortic aneurysm10.5
24pyelonephritis10.4
25renal pelvis carcinoma10.4
26ureterocele10.3
27hypertension10.3
28turner syndrome10.3
29neurofibromatosis10.2
30renovascular hypertension10.2
31glomerulonephritis10.2
32renal pelvis transitional cell carcinoma10.2
33xanthogranulomatous pyelonephritis10.2
34acute pyelonephritis10.2
35renal pelvis squamous cell carcinoma10.2
36aortic disease10.2
37kidney angiomyolipoma10.2
38mature teratoma10.2
39nephroblastoma10.2
40nephrotic syndrome10.2
41thrombocytopenia10.2
42arteriovenous fistula10.0
43thrombocytopenia-absent radius syndrome10.0
44ureteral obstruction10.0
45membranous glomerulonephritis10.0
46dyskeratosis congenita10.0
47papillary cystadenocarcinoma10.0
48fanconi's anemia10.0
49papillary renal cell carcinoma10.0
50somatostatinoma10.0

Graphical network of the top 20 diseases related to Horseshoe Kidney:



Diseases related to horseshoe kidney

Clinical Features for Horseshoe Kidney

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Drugs & Therapeutics for Horseshoe Kidney

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Horseshoe Kidney

Search CenterWatch for Horseshoe Kidney

Genetic Tests for Horseshoe Kidney

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Anatomical Context for Horseshoe Kidney

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32MalaCards
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MalaCards organs/tissues related to Horseshoe Kidney:

32
Kidney

Animal Models for Horseshoe Kidney or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Horseshoe Kidney:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.0TSC2, ACTC1, REN, EPO, CDX2, SYP

Publications for Horseshoe Kidney

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Genetic Variations for Horseshoe Kidney

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Expression for genes affiliated with Horseshoe Kidney

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Horseshoe Kidney

Search GEO for disease gene expression data for Horseshoe Kidney.

Pathways for genes affiliated with Horseshoe Kidney

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49PharmGKB, 37NCBI BioSystems Database, 29KEGG, 53Reactome, 4Cell Signaling Technology
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Compounds for genes affiliated with Horseshoe Kidney

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Horseshoe Kidney according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4CALB2
2cilazapril44 1111.4MME
3happ4410.2MME, SYP
4sampatrilat4410.1REN, MME
5omapatrilat4410.0REN, MME
6smcc4410.0SYP, ENO2
7fludrocortisone44 28 1111.9EPO, REN
8pimonidazole449.9CA9, EPO
9fosinopril44 1110.9REN, MME
10metanephrine44 2410.9REN, ENO2
11s 100449.8ENO2, ACTC1, SYP
12vanillylmandelic acid44 2410.8REN, ENO2
13enalapril44 49 1111.8MME, REN, EPO
14enalaprilat449.7REN, MME
15acetazolamide44 1110.6CA9, EPO
16octreotide44 59 28 1112.5EPO, MME, ENO2
17dexamethasone44 49 28 1112.5REN, MME, ENO2
18reticulin449.5KRT7, ACTC1, SYP
19catecholamine449.5SYP, REN, ENO2
20silver449.5ENO2, CALB2, SYP
21lisinopril44 11 2411.5MME, REN
22acth449.3ENO2, MME, SYP, REN
235-hydroxytryptamine449.2ENO2, CALB2, SYP, MME
24chloride449.1CA9, ENO2, MME, REN
25dopamine44 28 11 2412.1CALB2, REN, MME, ENO2
26acetylcholine44 49 28 11 2413.1CALB2, SYP, MME, ENO2
27potassium44 11 2411.1REN, MME, ENO2, SYP
28ribonucleic acid449.0MME, ACTC1, ENO2, KRT20
29forskolin44 49 1111.0REN, MME, ENO2, SYP
305-aza-2deoxycytidine448.9CDX2, EPO, KRT7, CA9
31thymidine44 249.8ENO2, CALB2, CDX2, MME, EPO
32creatinine448.7ACTC1, EPO, MME, REN, SYP, ENO2
33glycogen44 249.7KRT7, ACTC1, SYP, ENO2, TSC2
34steroid448.5ACTC1, CALB2, SYP, CDX2, REN, TSC2
35arginine448.5MME, TSC2, HNF1B, REN, KRT7
36nitric oxide44 11 2410.5MME, REN, SYP, CALB2, ENO2
37oxygen44 249.5CA9, EPO, TSC2, MME, ACTC1, ENO2
38mucicarmine448.4SYP, KRT20, KRT7, CALB2, ACTC1
39b 723448.4ACTC1, KRT7, KRT20, SYP, CALB2
40formaldehyde44 249.4ENO2, ACTC1, KRT20, KRT7, SYP
41glucose448.3HNF1B, REN, KRT7, ACTC1, TSC2, CA9
42retinoic acid44 249.3ACTC1, HNF1B, SYP, ENO2, MME, KRT7
43iron44 249.2EPO, KRT7, KRT20, ACTC1, ENO2
44hematoxylin447.9ACTC1, KRT20, KRT7, ENO2, CALB2, SYP
45calcium44 49 11 2410.8MME, ENO2, ACTC1, REN, CDX2, SYP
46progesterone44 59 28 11 2410.8MME, KRT20, ACTC1, CDX2, CALB2, SYP
47testosterone44 59 11 249.8EPO, SYP, CALB2, ACTC1, KRT20, TSC2
48paraffin446.5KRT20, TSC2, ENO2, ACTC1, KRT7, MME
49vegf446.5REN, EPO, SYP, CA9, MME, KRT20
50tyrosine446.1TSC2, ENO2, ACTC1, MME, KRT20, KRT7

GO Terms for genes affiliated with Horseshoe Kidney

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16Gene Ontology
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Cellular components related to Horseshoe Kidney according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projection terminusGO:0443069.9MME, SYP

Biological processes related to Horseshoe Kidney according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:0504359.7MME, REN
2regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.6EPO, CA9
3angiotensin maturationGO:0020039.5MME, REN
4kidney developmentGO:0018229.5MME, REN, HNF1B

Products for genes affiliated with Horseshoe Kidney

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Sources for Horseshoe Kidney

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet