Aliases & Classifications for Horseshoe Kidney

MalaCards integrated aliases for Horseshoe Kidney:

Name: Horseshoe Kidney 49 28

Classifications:



Summaries for Horseshoe Kidney

MalaCards based summary : Horseshoe Kidney is related to hepatoid adenocarcinoma and cystadenoma. An important gene associated with Horseshoe Kidney is GJB2 (Gap Junction Protein Beta 2). The drugs Fludarabine and alemtuzumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and colon, and related phenotypes are growth/size/body region and cardiovascular system

Wikipedia : 72 Horseshoe kidney, also known as ren arcuatus (in Latin), renal fusion or super kidney, is a congenital... more...

Related Diseases for Horseshoe Kidney

Diseases related to Horseshoe Kidney via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 347)
# Related Disease Score Top Affiliating Genes
1 hepatoid adenocarcinoma 30.0 CDX2 EGFR
2 cystadenoma 29.6 CHGA KRT20 KRT7 SYP
3 transitional cell carcinoma 29.5 EGFR ENO2 KRT20 KRT7
4 cholangiocarcinoma 29.4 CDX2 KRT20 KRT7
5 intrahepatic cholangiocarcinoma 29.2 CDX2 EGFR KRT20 KRT7
6 renal cell carcinoma, nonpapillary 29.0 EGFR ENO2 HNF1B KRT20 KRT7 NKX2-1
7 mucinous adenocarcinoma 28.9 CDX2 EGFR KRT20 KRT7 NKX2-1
8 neuroendocrine tumor 28.8 CHGA ENO2 KRT20 KRT7 NKX2-1 SYP
9 cystic teratoma 28.7 CDX2 ENO2 KRT20 KRT7 NKX2-1 SYP
10 teratoma 28.6 ACTC1 CDX2 ENO2 KRT20 KRT7 NKX2-1
11 renal cysts and diabetes syndrome 11.1
12 ritscher-schinzel syndrome 1 11.0
13 faciocardiorenal syndrome 11.0
14 lathosterolosis 11.0
15 joubert syndrome 18 11.0
16 anophthalmos with limb anomalies 11.0
17 aneurysm 10.6
18 aortic aneurysm 10.6
19 aortic aneurysm, familial abdominal, 1 10.6
20 ureter small cell carcinoma 10.5 CHGA SYP
21 esophageal neuroendocrine tumor 10.5 CHGA SYP
22 acinar cell cystadenocarcinoma 10.5 CHGA SYP
23 peritoneal serous adenocarcinoma 10.5 CHGA SYP
24 cellular ependymoma 10.5 CHGA SYP
25 primary hepatic neuroendocrine carcinoma 10.5 CHGA SYP
26 gastrointestinal neuroendocrine tumor 10.5 CHGA SYP
27 chordoid meningioma 10.4 CHGA SYP
28 conventional angiosarcoma 10.4 CHGA SYP
29 malignant sertoli cell tumor 10.4 ENO2 SYP
30 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
31 cutaneous ganglioneuroma 10.4 ENO2 SYP
32 pancreatic somatostatinoma 10.4 ENO2 SYP
33 extrahepatic bile duct adenocarcinoma 10.4 ENO2 SYP
34 papillary tumor of the pineal region 10.4 ENO2 SYP
35 orbital cancer 10.3 ENO2 SYP
36 ovarian carcinosarcoma 10.3 ENO2 SYP
37 mature teratoma of the ovary 10.3 ENO2 KRT20
38 adenoma of the pancreas 10.3 CHGA KRT20 SYP
39 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 SYP
40 angiocentric glioma 10.3 ACTC1 SYP
41 cerebellum cancer 10.3 ENO2 SYP
42 cerebral neuroblastoma 10.3 ENO2 SYP
43 ossifying fibromyxoid tumor 10.3 ACTC1 ENO2
44 epithelioid leiomyosarcoma 10.3 ACTC1 ENO2
45 binswanger's disease 10.3 ACTC1 CHGA SYP
46 intracranial primitive neuroectodermal tumor 10.3 CHGA ENO2
47 extraosseous chondrosarcoma 10.3 ENO2 SYP
48 cystic basal cell carcinoma 10.3 KRT20 KRT7
49 seminal vesicle adenocarcinoma 10.3 KRT20 KRT7
50 transverse colon cancer 10.3 KRT20 KRT7

Graphical network of the top 20 diseases related to Horseshoe Kidney:



Diseases related to Horseshoe Kidney

Symptoms & Phenotypes for Horseshoe Kidney

MGI Mouse Phenotypes related to Horseshoe Kidney:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.96 GJB2 HNF1B NKX2-1 ACTC1 REN CDX2
2 cardiovascular system MP:0005385 9.92 GJB2 NKX2-1 ACTC1 REN CDX2 CHGA
3 homeostasis/metabolism MP:0005376 9.85 GJB2 HNF1B KRT7 NKX2-1 ACTC1 REN
4 normal MP:0002873 9.61 NKX2-1 ACTC1 REN CALB2 CDX2 SYP
5 renal/urinary system MP:0005367 9.1 HNF1B KRT7 REN CHGA TSC2 EGFR

Drugs & Therapeutics for Horseshoe Kidney

Drugs for Horseshoe Kidney (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
2
alemtuzumab Approved, Investigational Phase 1 216503-57-0
3 Immunosuppressive Agents Phase 1
4 Antimetabolites Phase 1
5 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Rft5-Dga to Deplete Alloreactive Cells for Pts With Fanconi Anemia After Haploidentical SCT Terminated NCT00586274 Phase 1 Fludarabine
2 Impact of Low Dose Fluoroscopy in Ureteroscopy Enrolling by invitation NCT02704949

Search NIH Clinical Center for Horseshoe Kidney

Genetic Tests for Horseshoe Kidney

Genetic tests related to Horseshoe Kidney:

# Genetic test Affiliating Genes
1 Horseshoe Kidney 28

Anatomical Context for Horseshoe Kidney

MalaCards organs/tissues related to Horseshoe Kidney:

38
Kidney, Bone, Colon, Pancreas, Spleen, Testis, Prostate

Publications for Horseshoe Kidney

Articles related to Horseshoe Kidney:

(show top 50) (show all 607)
# Title Authors Year
1
Isolated fetal horseshoe kidney does not seem to increase the risk for abnormal chromosomal microarray results. ( 29367169 )
2018
2
Case - Laparoscopic transperitoneal partial nephrectomy of T3a renal cell carcinoma within a horseshoe kidney. ( 29405905 )
2018
3
Incidence and characteristics of kidney stones in patients with horseshoe kidney: A systematic review and meta-analysis. ( 29416282 )
2018
4
Renal pelvic cancer with spleen invasion arising in horseshoe kidney; a case report. ( 29276682 )
2018
5
Percutaneous Cryoablation of the Horseshoe Kidney: An Initial Experience. ( 28343584 )
2017
6
Evaluation of the accuracy of renal depth estimation formulas in horseshoe kidney. ( 29245358 )
2017
7
Massive Renal Replacement Lipomatosis With Foci of Xanthogranulomatous Pyelonephritis in a Horseshoe Kidney. ( 28443241 )
2017
8
The rarest phenomenon of flexible ureterolithotripsy: Kidney stone in supernumerary type combination with a horseshoe kidney. ( 29118544 )
2017
9
Renal Cell Carcinoma in a Pregnant Woman With Horseshoe Kidney. ( 28507908 )
2017
10
Clear cell sarcoma of kidney involving a horseshoe kidney and harboring EGFR internal tandem duplication. ( 28440018 )
2017
11
A game of two halves: inconsistent renal allograft function in two recipients of a split horseshoe kidney. ( 29129029 )
2017
12
En bloc transplantation of horseshoe kidney in Korea. ( 28289672 )
2017
13
18F-FDG PET/CT in Renal Infections: Evidence of Acute Pyelonephritis in a Horseshoe Kidney. ( 27879491 )
2017
14
Hybrid Repair of an Abdominal Aortic Aneurysm: Debranching with Endovascular Aneurysm Repair in a Patient with Horseshoe Kidney. ( 29034019 )
2017
15
Retroperitoneoscopic Partial Nephrectomy for a Horseshoe Kidney Tumor. ( 28435792 )
2017
16
Metastatic Mucinous Adenocarcinoma and Carcinoid Tumor Arising From a Mature Cystic Teratoma of a Horseshoe Kidney. ( 28083486 )
2017
17
Robotic-Assisted Laparoscopic Partial Nephrectomy in a Horseshoe Kidney. a Case Report and Review of the Literature. ( 29288785 )
2017
18
Multimodality imaging spectrum of complications of horseshoe kidney. ( 28744072 )
2017
19
Minimal change disease in horseshoe kidney. ( 28690757 )
2017
20
Scrotal extraperitoneal ureteroinguinal hernia with a horseshoe kidney. ( 28480543 )
2017
21
Challenging case of horseshoe kidney double fracture. ( 29078159 )
2017
22
Horseshoe Kidney ( 28613757 )
2017
23
Recurrent renal calculi in coexistence of horseshoe kidney and medullary sponge kidney. ( 28479783 )
2017
24
RE: Endoscopic management of urolithiasis in the horseshoe kidney. ( 27215484 )
2016
25
May-Thurner Syndrome and Horseshoe Kidney. ( 26916939 )
2016
26
Retroperitoneoscopic pyeloplasty for the management of pelvic-ureteric junction obstruction in horseshoe kidney: our initial experience. ( 27402587 )
2016
27
Retroaortic Variant of Reverse Horseshoe Kidney With Butterfly Vertebrae Presenting as Neurogenic Bladder. ( 27282812 )
2016
28
Left Renal Vein Compression and Horseshoe Kidney: An Extraordinary Association. ( 27304675 )
2016
29
Renal Transplantation From a Living Donor With a Horseshoe Kidney. ( 27500246 )
2016
30
The horseshoe kidney: Surgical anatomy and embryology. ( 27324557 )
2016
31
Branched Endograft Common Iliac Aneurysm Repair in a Patient with Horseshoe Kidney. ( 26922107 )
2016
32
Do Outcomes of Percutaneous Nephrolithotomy in Horseshoe Kidney in Children Differ from Adults? A Single-Center Experience. ( 26791336 )
2016
33
Retroperitoneoscopy Technique-Assisted Percutaneous Nephrolithotomy for Complexity Horseshoe Kidney with Renal Stones. ( 27450075 )
2016
34
Reverse U-shaped horseshoe kidney accompanied by gibbus deformity and spina bifida. ( 27114084 )
2016
35
Endoscopic Management of Urolithiasis in the Horseshoe Kidney. ( 26772644 )
2016
36
Transmesenteric robot-assisted pyeloplasty for ureteropelvic junction obstruction in horseshoe kidney. ( 27286132 )
2016
37
Organ-Preserving Surgical Treatment of a Horseshoe Kidney Occupied by a Large Renal Cell Carcinoma with Extensive Venous Invasion: A Case Report. ( 26863421 )
2016
38
Laparoscopic heminephrectomy for benign and malignant diseases of the horseshoe kidney. ( 28073187 )
2016
39
Robot-assisted laparoscopic pyeloplasty in a pediatric patient with horseshoe kidney: surgical technique and review of the literature. ( 27516351 )
2016
40
Bladder agenesis, ectopic ureters and a multicystic dysplastic horseshoe kidney in one twin newborn with normal amniotic fluid index in utero. ( 27932430 )
2016
41
Laparoscopic Pyeloplasty in children with Horseshoe Kidney. ( 27778495 )
2016
42
Reply to Letter to Editor Re: Endoscopic Management of Urolithiasis in the Horseshoe Kidney. ( 27237778 )
2016
43
Renal cell carcinoma in a horseshoe kidney: Report of a rare disease. ( 28000646 )
2016
44
A Novel Chimney Approach for Management of Horseshoe Kidney During EVAR. ( 28856318 )
2016
45
Gross Anatomical Dissection of a Horseshoe Kidney: The Eighth Specimen in Our Medical School. ( 26935444 )
2016
46
Partial and hemi-nephrectomy for renal malignancy in patients with horseshoe kidney. ( 26892057 )
2016
47
Comparison of shock wave lithotripsy (SWL) and retrograde intrarenal surgery (RIRS) for treatment of stone disease in horseshoe kidney patients. ( 27136473 )
2016
48
Aspiration Thrombectomy of Acute Atrial Fibrillation-related Renal Artery Thromboembolism in a Patient with Horseshoe Kidney. ( 27354320 )
2016
49
Laparoscopic Pyeloplasty for Ureteropelvic Junction Obstruction in an Incompletely Duplicated Collecting System in a Patient with a Horseshoe Kidney. ( 27733990 )
2016
50
The Robotic-Assisted Laparoscopy, Isthmusectomy, and Pyeloplasty in a Patient With Horseshoe Kidney: A Case Report. ( 26765474 )
2016

Variations for Horseshoe Kidney

ClinVar genetic disease variations for Horseshoe Kidney:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GJB2 NM_004004.5(GJB2): c.269T> C (p.Leu90Pro) single nucleotide variant Pathogenic rs80338945 GRCh37 Chromosome 13, 20763452: 20763452

Expression for Horseshoe Kidney

Search GEO for disease gene expression data for Horseshoe Kidney.

Pathways for Horseshoe Kidney

GO Terms for Horseshoe Kidney

Biological processes related to Horseshoe Kidney according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cerebral cortex cell migration GO:0021795 8.62 EGFR NKX2-1

Sources for Horseshoe Kidney

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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