Aliases & Classifications for Horseshoe Kidney

MalaCards integrated aliases for Horseshoe Kidney:

Name: Horseshoe Kidney 50 29

Classifications:



Summaries for Horseshoe Kidney

MalaCards based summary : Horseshoe Kidney is related to neuroendocrine tumor and mature teratoma. An important gene associated with Horseshoe Kidney is GJB2 (Gap Junction Protein Beta 2). The drugs alemtuzumab and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and colon, and related phenotypes are growth/size/body region and normal

Wikipedia : 72 Horseshoe kidney, also known as ren arcuatus (in Latin), renal fusion or super kidney, is a congenital... more...

Related Diseases for Horseshoe Kidney

Diseases related to Horseshoe Kidney via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 310)
id Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 30.4 CDX2 KRT20
2 mature teratoma 30.1 ENO2 NKX2-1 SYP
3 ischemia 30.1 ACTC1 ENO2 SYP
4 intrahepatic cholangiocarcinoma 29.1 CDX2 KRT20 KRT7
5 seminoma 29.1 CDX2 KRT7 SYP
6 renal cysts and diabetes syndrome 11.0
7 ritscher-schinzel syndrome 1 10.8
8 joubert syndrome 18 10.8
9 lathosterolosis 10.8
10 faciocardiorenal syndrome 10.8
11 anophthalmos with limb anomalies 10.8
12 staphyloenterotoxemia 10.8 HNF1B KRT20
13 2q31.1 microdeletion syndrome 10.8 ENO2 SYP
14 paranasal sinus cancer 10.7 ENO2 SYP
15 situs inversus totalis with cystic dysplasia of kidneys and pancreas 10.7 ENO2 SYP
16 glomus tumor 10.7 ENO2 SYP
17 bronchus adenoma 10.7 ENO2 SYP
18 pemphigus foliaceus 10.7 ENO2 SYP
19 malignant ovarian mixed epithelial neoplasm 10.7 CHGA SYP
20 gallbladder adenocarcinoma 10.7 ENO2 SYP
21 chondroid chordoma 10.7 ENO2 SYP
22 familial renal oncocytoma 10.7 ENO2 KRT20
23 spinal cord ependymoma 10.7 CHGA SYP
24 signet ring cell intrahepatic cholangiocarcinoma 10.7 CHGA SYP
25 brain glioma 10.7 ENO2 SYP
26 basophilic carcinoma 10.7 CHGA SYP
27 hair disease 10.7 ENO2 SYP
28 pleural empyema 10.7 NKX2-1 SYP
29 neurogenic thoracic outlet syndrome 10.7 CHGA SYP
30 space motion sickness 10.7 KRT20 SYP
31 rh isoimmunization 10.7 ENO2 SYP
32 breast pericanalicular fibroadenoma 10.7 KRT20 NKX2-1
33 myoma 10.7 ACTC1 ENO2
34 aicardi-goutieres syndrome 10.7 CHGA SYP
35 diffuse infiltrative lymphocytosis syndrome 10.6 CHGA SYP
36 myxoid leiomyosarcoma 10.6 ACTC1 ENO2
37 reticular pattern testicular yolk sac tumor 10.6 CHGA SYP
38 papillary glioneuronal tumor 10.6 ACTC1 SYP
39 thymus large cell carcinoma 10.6 ENO2 SYP
40 childhood choroid plexus cancer 10.6 ENO2 SYP
41 brachial plexus neuritis 10.6 ENO2 SYP
42 malignant granular cell myoblastoma 10.6 ENO2 SYP
43 thymus small cell carcinoma 10.6 ENO2 SYP
44 thyroid sarcoma 10.6 CHGA SYP
45 behcet's syndrome arthropathy 10.6 ENO2 SYP
46 supratentorial primitive neuroectodermal tumor 10.6 CHGA ENO2
47 pineoblastoma 10.6 ENO2 SYP
48 olfactory neural tumor 10.6 ENO2 SYP
49 sensory organ benign neoplasm 10.6 ENO2 SYP
50 enteric pattern testicular yolk sac tumor 10.6 CHGA ENO2

Graphical network of the top 20 diseases related to Horseshoe Kidney:



Diseases related to Horseshoe Kidney

Symptoms & Phenotypes for Horseshoe Kidney

MGI Mouse Phenotypes related to Horseshoe Kidney:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.61 ACTC1 CDX2 CHGA ENO2 GJB2 HNF1B
2 normal MP:0002873 9.23 ACTC1 CALB2 CDX2 GJB2 NKX2-1 REN

Drugs & Therapeutics for Horseshoe Kidney

Drugs for Horseshoe Kidney (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
alemtuzumab Approved, Investigational Phase 1 216503-57-0
2
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
3 Antimetabolites Phase 1
4 Antimetabolites, Antineoplastic Phase 1
5 Immunosuppressive Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Use of Rft5-Dga to Deplete Alloreactive Cells for Pts With Fanconi Anemia After Haploidentical SCT Terminated NCT00586274 Phase 1 Fludarabine
2 Impact of Low Dose Fluoroscopy in Ureteroscopy Enrolling by invitation NCT02704949

Search NIH Clinical Center for Horseshoe Kidney

Genetic Tests for Horseshoe Kidney

Genetic tests related to Horseshoe Kidney:

id Genetic test Affiliating Genes
1 Horseshoe Kidney 29

Anatomical Context for Horseshoe Kidney

MalaCards organs/tissues related to Horseshoe Kidney:

39
Kidney, Bone, Colon, Pancreas, Testis, Prostate, Lung

Publications for Horseshoe Kidney

Articles related to Horseshoe Kidney:

(show top 50) (show all 596)
id Title Authors Year
1
Renal Cell Carcinoma in a Pregnant Woman With Horseshoe Kidney. ( 28507908 )
2017
2
18F-FDG PET/CT in Renal Infections: Evidence of Acute Pyelonephritis in a Horseshoe Kidney. ( 27879491 )
2017
3
Recurrent renal calculi in coexistence of horseshoe kidney and medullary sponge kidney. ( 28479783 )
2017
4
Percutaneous Cryoablation of the Horseshoe Kidney: An Initial Experience. ( 28343584 )
2017
5
Metastatic Mucinous Adenocarcinoma and Carcinoid Tumor Arising From a Mature Cystic Teratoma of a Horseshoe Kidney. ( 28083486 )
2017
6
En bloc transplantation of horseshoe kidney in Korea. ( 28289672 )
2017
7
Multimodality imaging spectrum of complications of horseshoe kidney. ( 28744072 )
2017
8
Retroperitoneoscopic Partial Nephrectomy for a Horseshoe Kidney Tumor. ( 28435792 )
2017
9
Horseshoe Kidney ( 28613757 )
2017
10
Clear cell sarcoma of kidney involving a horseshoe kidney and harboring EGFR internal tandem duplication. ( 28440018 )
2017
11
Minimal change disease in horseshoe kidney. ( 28690757 )
2017
12
Scrotal extraperitoneal ureteroinguinal hernia with a horseshoe kidney. ( 28480543 )
2017
13
Massive Renal Replacement Lipomatosis With Foci of Xanthogranulomatous Pyelonephritis in a Horseshoe Kidney. ( 28443241 )
2017
14
Comparison of shock wave lithotripsy (SWL) and retrograde intrarenal surgery (RIRS) for treatment of stone disease in horseshoe kidney patients. ( 27136473 )
2016
15
Retroaortic Variant of Reverse Horseshoe Kidney With Butterfly Vertebrae Presenting as Neurogenic Bladder. ( 27282812 )
2016
16
The Robotic-Assisted Laparoscopy, Isthmusectomy, and Pyeloplasty in a Patient With Horseshoe Kidney: A Case Report. ( 26765474 )
2016
17
Retroperitoneoscopic pyeloplasty for the management of pelvic-ureteric junction obstruction in horseshoe kidney: our initial experience. ( 27402587 )
2016
18
Do Outcomes of Percutaneous Nephrolithotomy in Horseshoe Kidney in Children Differ from Adults? A Single-Center Experience. ( 26791336 )
2016
19
Retroperitoneoscopy Technique-Assisted Percutaneous Nephrolithotomy for Complexity Horseshoe Kidney with Renal Stones. ( 27450075 )
2016
20
Horseshoe kidney with growth retardation: Don't forget Turner syndrome. ( 27976569 )
2016
21
Robot-assisted laparoscopic pyeloplasty in a pediatric patient with horseshoe kidney: surgical technique and review of the literature. ( 27516351 )
2016
22
Gross Anatomical Dissection of a Horseshoe Kidney: The Eighth Specimen in Our Medical School. ( 26935444 )
2016
23
RE: Endoscopic management of urolithiasis in the horseshoe kidney. ( 27215484 )
2016
24
Reverse U-shaped horseshoe kidney accompanied by gibbus deformity and spina bifida. ( 27114084 )
2016
25
Laparoscopic Pyeloplasty for Ureteropelvic Junction Obstruction in an Incompletely Duplicated Collecting System in a Patient with a Horseshoe Kidney. ( 27733990 )
2016
26
The horseshoe kidney: Surgical anatomy and embryology. ( 27324557 )
2016
27
Left Renal Vein Compression and Horseshoe Kidney: An Extraordinary Association. ( 27304675 )
2016
28
May-Thurner Syndrome and Horseshoe Kidney. ( 26916939 )
2016
29
Aspiration Thrombectomy of Acute Atrial Fibrillation-related Renal Artery Thromboembolism in a Patient with Horseshoe Kidney. ( 27354320 )
2016
30
Branched Endograft Common Iliac Aneurysm Repair in a Patient with Horseshoe Kidney. ( 26922107 )
2016
31
Organ-Preserving Surgical Treatment of a Horseshoe Kidney Occupied by a Large Renal Cell Carcinoma with Extensive Venous Invasion: A Case Report. ( 26863421 )
2016
32
Renal cell carcinoma in a horseshoe kidney: Report of a rare disease. ( 28000646 )
2016
33
Endoscopic Management of Urolithiasis in the Horseshoe Kidney. ( 26772644 )
2016
34
Transmesenteric robot-assisted pyeloplasty for ureteropelvic junction obstruction in horseshoe kidney. ( 27286132 )
2016
35
Laparoscopic heminephrectomy for benign and malignant diseases of the horseshoe kidney. ( 28073187 )
2016
36
Laparoscopic Pyeloplasty in children with Horseshoe Kidney. ( 27778495 )
2016
37
Renal Transplantation From a Living Donor With a Horseshoe Kidney. ( 27500246 )
2016
38
A Novel Chimney Approach for Management of Horseshoe Kidney During EVAR. ( 28856318 )
2016
39
Bladder agenesis, ectopic ureters and a multicystic dysplastic horseshoe kidney in one twin newborn with normal amniotic fluid index in utero. ( 27932430 )
2016
40
Reply to Letter to Editor Re: Endoscopic Management of Urolithiasis in the Horseshoe Kidney. ( 27237778 )
2016
41
Partial and hemi-nephrectomy for renal malignancy in patients with horseshoe kidney. ( 26892057 )
2016
42
Evaluation of Renal Artery Anomalies Associated with Horseshoe Kidney Using CT Angiography. ( 25843445 )
2015
43
A Rare Case of a Renal Cell Carcinoma Confined to the Isthmus of a Horseshoe Kidney. ( 26185705 )
2015
44
Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature. ( 26301110 )
2015
45
Outcome of ureteroscopy for stone disease in patients with horseshoe kidney: Review of world literature. ( 26692667 )
2015
46
Glomerular filtration rate measured by (99m) Tc-DTPA renal dynamic imaging is significantly lower than that estimated by the CKD-EPI equation in horseshoe kidney patients. ( 26517584 )
2015
47
Transplantation of a horseshoe kidney from a living donor: Case report, long term outcome and donor safety. ( 26299249 )
2015
48
An innovative technique of robotic-assisted/laparoscopic re-pyeloplasty in horseshoe kidney in patients with failed previous pyeloplasty for ureteropelvic junction obstruction. ( 26675936 )
2015
49
Horseshoe kidney transplantation. ( 26120481 )
2015
50
Horseshoe Kidney Incidentally Revealed on Meckel Scintigraphy. ( 25706795 )
2015

Variations for Horseshoe Kidney

ClinVar genetic disease variations for Horseshoe Kidney:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GJB2 NM_004004.5(GJB2): c.269T> C (p.Leu90Pro) single nucleotide variant Pathogenic rs80338945 GRCh37 Chromosome 13, 20763452: 20763452

Expression for Horseshoe Kidney

Search GEO for disease gene expression data for Horseshoe Kidney.

Pathways for Horseshoe Kidney

GO Terms for Horseshoe Kidney

Sources for Horseshoe Kidney

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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