Hprt-related Gout malady

MalaCards: Hprt-related Gout, also known as GOUT, is related to gout and hyperuricemia. An important gene associated with Hprt-related Gout is HPRT1 (hypoxanthine phosphoribosyltransferase 1). The drugs gout suppressants and aspirin pwdr [va product] have been mentioned in the context of this disorder.

OMIM: 300323

hprt-related gout 7 33 gout 43

Diseases related to hprt-related gout by text searches and GeneDecks gene sharing:

(show all 33)

id	Related Disease	Score	Top Affiliating Genes
1	gout	11.5
2	hyperuricemia	8.6
3	familial juvenile hyperuricaemic nephropathy	7.5
4	gout, hprt1-related	7.2
5	lesch-nyhan syndrome	7.2
6	phosphoribosylpyrophosphate synthetase superactivity	6.9
7	familial juvenile hyperuricemic nephropathy	6.6
8	insulin resistance	6.6
9	arthritis	6.0
10	chondrocalcinosis 2	6.0
11	phosphoribosyl pyrophosphate synthetase-related gout	6.0
12	umod-associated kidney disease	6.0
13	nephronophthisis	5.1
14	nephropathy	5.1
15	osteoarthritis	5.1
16	parkinson's disease	5.1
17	prostate cancer	5.1
18	prostatitis	5.1
19	pseudogout	5.1
20	rheumatoid arthritis	5.1
21	adenine phosphoribosyltransferase deficiency	5.1
22	rheumatoid vasculitis	5.1
23	blindness	5.1
24	ren-related kidney disease	5.1
25	bursitis	5.1
26	toe injuries and disorders	5.1
27	down syndrome	5.1
28	vasculitis	5.1
29	familial juvenile hyperuricemic nephropathy type 2	5.1
30	werner syndrome	5.1
31	hyperuricemic nephropathy	5.1
32	kidney disease	5.1
33	medullary cystic kidney disease 1	5.1

Clinical features from OMIM: 300323

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 [ms400] antigout agents, acetylsalicylate sodium, aspirin, aspirin pwdr [va product], gout suppressants, ibuprofen, naproxen, naproxen sodium, probenecid, sulfinpyrazone

Genes related to hprt-related gout according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0	Disorders