MCID: HTL002
MIFTS: 38

Htlv-1 Associated Myelopathy malady

Summaries for Htlv-1 Associated Myelopathy

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43NINDS, 32MalaCards
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NINDS:43 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes

MalaCards: Htlv-1 Associated Myelopathy, also known as myelopathy, htlv-1-associated, is related to tropical spastic paraparesis and dermatitis. An important gene associated with Htlv-1 Associated Myelopathy is KLRK1 (killer cell lectin-like receptor subfamily K, member 1), and among its related pathways are Apoptosis Pathway and TGF-Beta Pathway. The compounds cycloheximide and pge2 have been mentioned in the context of this disorder. Related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Aliases & Classifications for Htlv-1 Associated Myelopathy

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60UMLS, 43NINDS, 44Novoseek
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Aliases & Descriptions:

htlv-1 associated myelopathy 43
myelopathy, htlv-1-associated 44
tropical spastic paraparesis 60


Related Diseases for Htlv-1 Associated Myelopathy

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17GeneCards, 18GeneDecks
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Diseases related to Htlv-1 Associated Myelopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1tropical spastic paraparesis31.3FASLG, CNTN2, MBP, CCL3, IL2RA, IL2
2dermatitis30.6CX3CR1
3t-cell leukemia30.6FASLG, HLA-B, NFKB1, MYC, CNTN2, GLI2
4leukemia30.6IL2, IL2RA, CNTN2, MYC, NFKB1, HLA-A
5vasculitis30.5NFKB1, HLA-B
6acute leukemia30.3IL2
7sarcoma30.3IL2, VDR
8cutaneous t cell lymphoma30.3IL2RA, IL2, FAS
9psoriasis30.3HLA-B, VDR, HLA-C, IL2, IL2RA, CX3CR1
10leprosy30.3IL2
11neuropathy30.3MBP
12thyroiditis30.3HLA-C, FASLG
13amyloidosis30.3RPS27A, HLA-B
14adult t-cell leukemia30.3CNTN2, IL2RA
15systemic lupus erythematosus30.3IL2, FAS, HLA-A, FASLG, CX3CR1, IL2RA
16multiple sclerosis30.2FASLG, HLA-C, HLA-B, HLA-A, VDR, CD274
17retrovirus-associated myelopathy10.5
18cerebritis10.5
19adult lymphoma10.5
20spinal cord disease10.5
21htlv-1 associated myelopathy/tropical spastic paraparesis10.4
22myelitis10.4
23lateral sclerosis10.4
24amyotrophic lateral sclerosis10.4
25strongyloidiasis10.2
26folliculitis10.2
27fibrous histiocytoma10.2
28acute t cell leukemia10.2
29postpartum depression10.2
30neuroaxonal dystrophy10.2
31central nervous system leukemia10.2
32protein s deficiency10.2
33lyme disease10.2
34cerebral lymphoma10.2
35spinal cord sarcoma10.2
36osteoporosis10.2
37central nervous system disease10.2
38histiocytoma10.2
39lupus erythematosus10.2
40nervous system disease10.2
41paraplegia10.2
42syphilis10.2
43t cell deficiency10.2
44acute ackee fruit intoxication10.2
45hemoglobinuria10.2
46lepromatous leprosy10.2
47hypertension10.2
48peripheral neuropathy10.2
49neurologic diseases10.2
50alopecia10.0VDR

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy:



Diseases related to htlv-1 associated myelopathy

Clinical Features for Htlv-1 Associated Myelopathy

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Drugs & Therapeutics for Htlv-1 Associated Myelopathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Genetic Tests for Htlv-1 Associated Myelopathy

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Anatomical Context for Htlv-1 Associated Myelopathy

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Animal Models for Htlv-1 Associated Myelopathy or affiliated genes

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36MGI
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Publications for Htlv-1 Associated Myelopathy

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Genetic Variations for Htlv-1 Associated Myelopathy

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Expression for genes affiliated with Htlv-1 Associated Myelopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Htlv-1 Associated Myelopathy

Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy.

Pathways for genes affiliated with Htlv-1 Associated Myelopathy

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59Tocris Bioscience, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG, 55SinoBiological, 52R&D Systems
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Pathways related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1IL2RA, JUN
2
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10.1IL2, IL2RA
39.9MYC, NFKB1, IL2RA
49.8IL2RA, IL2, JUN
59.8JUN, NFKB1, MYC
6
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
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9.8JUN, NFKB1, MYC
79.8JUN, NFKB1, IL2
89.8IL2, JUN, NFKB1
9
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9.8NFKB1, FAS, JUN
109.7HLA-B, HLA-C, HLA-A
11
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9.7HLA-B, HLA-C, HLA-A
12
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9.7FASLG, IL2RA, IL2, JUN
13
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9.7JUN, NFKB1, MYC, FASLG
14
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9.7IL2RA, IL2, RPS27A, NFKB1
15
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9.6JUN, MYC, IL2RA, IL2
169.6JUN, MYC, IL2RA, IL2
17
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9.6JUN, IL2RA, NFKB1, IL2
18
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9.6IL2, JUN, IL2RA, NFKB1
199.6NFKB1, JUN, IL2, MYC
20
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9.6JUN, FAS, FASLG, NFKB1
21
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9.6FAS, NFKB1, JUN, FASLG
229.6NFKB1, JUN, MYC, GLI2
23
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9.6FAS, HLA-A, FASLG, HLA-C
249.5HLA-A, FASLG, JUN, IL2RA, IL2
25
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9.5IL2, FASLG, NFKB1, MYC, IL2RA
269.5IL2, IL2RA, NFKB1, MYC, FASLG
27
Immune response IL-2 activation and signaling pathway
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9.4JUN, NFKB1, MYC, IL2, IL2RA
28
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9.4IL2, MYC, IL2RA, NFKB1, JUN
29
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9.4NFKB1, MYC, IL2, JUN, IL2RA
30
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9.4JUN, FAS, FASLG, NFKB1, MYC
319.4MYC, NFKB1, FASLG, FAS, JUN
32
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9.4JUN, FASLG, FAS, NFKB1, MYC
33
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9.4NFKB1, JUN, FASLG, MYC, FAS
34
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9.4JUN, PDCD1, NFKB1, IL2, FAS
359.3CNTN2, HLA-B, HLA-C, HLA-A, PDCD1
369.3NFKB1, HLA-A, HLA-B, JUN, HLA-C
37
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9.2IL2, IL2RA, FASLG, FAS, CCL3
38
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9.2KLRK1, HLA-A, RPS27A, NFKB1, HLA-C, HLA-B
39
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9.1IL2RA, JUN, CX3CR1, NFKB1, CCL3, IL2
40
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9.1IL2RA, HLA-A, HLA-B, HLA-C, FASLG, FAS
419.1HLA-C, HLA-B, HLA-A, NFKB1, MYC, JUN
42
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8.9HLA-A, HLA-C, IL2RA, NFKB1, IL2, RPS27A
43
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8.9CCL3, IL2, IL2RA, NFKB1, HLA-A, FASLG
44
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8.9FASLG, NFKB1, MYC, CX3CR1, FAS, CCL3
45
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8.9RPS27A, HLA-A, NFKB1, HLA-B, HLA-C, FASLG
46
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8.8JUN, CCL3, FASLG, IL2, FAS, NFKB1
478.7JUN, IL2, IL2RA, MYC, NFKB1, HLA-A
48
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8.5IL2, KLRK1, JUN, FAS, FASLG, HLA-C
49
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8.4IL2, IL2RA, NFKB1, HLA-A, HLA-B, HLA-C
50
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8.1IL2, HLA-B, HLA-A, NFKB1, CD274, IL2RA

Compounds for genes affiliated with Htlv-1 Associated Myelopathy

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.8FASLG
2pge24410.6IL2
3butyrate4410.5RPS27A
4indomethacin44 59 28 1113.4RPS27A, MBP
5estrogen4410.4VDR, CNTN2
6prednisolone44 28 1112.1IL2RA, MYC, MBP
7ivig4410.1MBP
8arsenite44 2411.1RPS27A, FAS, VDR, FASLG
9aspartate4410.0VDR, FASLG, HLA-B, RPS27A
10sodium arsenite449.9IL2RA, MYC, JUN, FASLG
112-chlorodeoxyadenosine449.9FASLG, FAS, IL2RA, IL2
12tamoxifen44 49 28 1112.9VDR, JUN, RPS27A, IL2, FASLG
13dexamethasone44 49 28 1112.9MYC, FASLG, FAS, JUN, VDR
14lactacystin449.8RPS27A, VDR, MYC, JUN, FASLG
152,5-oligoadenylate449.8MYC, IL2RA, IL2, HLA-B
16serine449.8HLA-B, CCL3, JUN, VDR
17anisomycin44 1110.8FAS, IL2RA, MYC, FASLG, JUN
18n-(4-hydroxyphenyl)retinamide449.7CNTN2, MYC, RPS27A, JUN
19polyinosinic-polycytidylic acid449.6IL2, HLA-B, CCL3, KLRK1
20mg 13244 5910.6RPS27A, JUN, FAS, FASLG, MYC, VDR
21c-d4t449.6IL2RA, IL2, FASLG
22camptothecin44 59 1111.6RPS27A, JUN, FASLG, MYC, CNTN2, FAS
235-aza-2deoxycytidine449.5HLA-B, MYC, FAS, RPS27A, FASLG, HLA-A
24herbimycin a44 5910.5IL2RA, IL2, MYC, FAS, RPS27A, JUN
25il 10449.5VDR, CCL3, IL2RA, IL2
26cyclophosphamide44 49 1111.5IL2RA, IL2, FASLG, MBP
27tacrolimus44 49 1111.4IL2RA, MYC, VDR, FASLG, CCL3, RPS27A
28rapamycin449.4RPS27A, FAS, MYC, IL2, JUN, FASLG
29genistein44 28 59 2 11 2414.3FASLG, MYC, IL2, IL2RA, JUN, FAS
30cytarabine44 49 1111.3MYC, JUN, FASLG, CCL3, MBP, FAS
315fluorouracil449.3FAS, FASLG, IL2, IL2RA, HLA-A, VDR
32n acetylcysteine449.3FASLG, IL2RA, MYC, RPS27A, JUN, MBP
33polysaccharide449.2IL2RA, FASLG, FAS, HLA-B, CCL3, RPS27A
34epinephrine44 11 2411.2RPS27A, CCL3, MBP, FASLG, IL2RA, FAS
35rantes449.2FAS, FASLG, CCL3, JUN, IL2RA, IL2
36paraffin449.2IL2RA, FASLG, FAS, MBP, RPS27A, HLA-B
37cisplatin44 49 59 1112.2FAS, RPS27A, FASLG, IL2RA, IL2, MYC
38adenylate449.1VDR, HLA-B, FASLG, MBP, RPS27A, HLA-A
39actinomycin d449.0FAS, FASLG, CCL3, JUN, RPS27A, MYC
40etoposide44 49 59 1112.0CNTN2, MYC, FAS, CCL3, JUN, NFKB1
41ionomycin448.9CNTN2, IL2RA, CD274, FASLG, FAS, CCL3
42arginine448.8IL2RA, CNTN2, VDR, HLA-A, HLA-B, FAS
43alanine448.7VDR, CNTN2, MYC, HLA-A, FASLG, MBP
44vegf448.7FASLG, CNTN2, CX3CR1, FAS, IL2RA, CCL3
45h2o2448.6HLA-B, CNTN2, FAS, MBP, CCL3, JUN
46cysteine448.6FASLG, RPS27A, JUN, FAS, CCL3, IL2RA
47thymidine44 249.5MBP, IL2, IL2RA, CNTN2, VDR, FAS
48retinoic acid44 249.3FAS, FASLG, HLA-B, VDR, MYC, CNTN2
49tyrosine448.2FAS, FASLG, HLA-B, HLA-A, MYC, CNTN2
50cyclosporin a44 28 599.9FASLG, CCL3, RPS27A, JUN, MBP, FAS

GO Terms for genes affiliated with Htlv-1 Associated Myelopathy

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16Gene Ontology
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Cellular components related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.9HLA-A, HLA-B, HLA-C
2integral to lumenal side of endoplasmic reticulum membraneGO:0715569.8HLA-C, HLA-B, HLA-A
3ER to Golgi transport vesicle membraneGO:0125079.7HLA-A, HLA-B, HLA-C
4early endosome membraneGO:0319019.7HLA-A, HLA-B, HLA-C
5external side of plasma membraneGO:0098979.5IL2RA, CD274, FASLG, FAS, PDCD1
6phagocytic vesicle membraneGO:0306709.4HLA-C, HLA-B, HLA-A
7plasma membraneGO:0058867.8RPS27A, PDCD1, MBP, FAS, HLA-C, HLA-B

Biological processes related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:04601310.4IL2RA, IL2
2inflammatory cell apoptotic processGO:00692510.4FAS, FASLG
3activation-induced cell death of T cellsGO:00692410.4FAS, IL2RA
4negative regulation of inflammatory responseGO:05072810.2IL2, IL2RA, NFKB1
5toll-like receptor 10 signaling pathwayGO:03416610.2RPS27A, JUN, NFKB1
6regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.2FASLG, FAS
7response to growth factor stimulusGO:07084810.2MYC, FASLG
8toll-like receptor 5 signaling pathwayGO:03414610.2RPS27A, JUN, NFKB1
9toll-like receptor TLR6:TLR2 signaling pathwayGO:03812410.2RPS27A, JUN, NFKB1
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00248010.1HLA-A, HLA-B, HLA-C
11toll-like receptor TLR1:TLR2 signaling pathwayGO:03812310.1RPS27A, JUN, NFKB1
12toll-like receptor 9 signaling pathwayGO:03416210.1NFKB1, JUN, RPS27A
13positive regulation of T cell mediated cytotoxicityGO:00191610.1HLA-A, HLA-B, HLA-C
14toll-like receptor 2 signaling pathwayGO:03413410.1RPS27A, JUN, NFKB1
15TRIF-dependent toll-like receptor signaling pathwayGO:03566610.1NFKB1, JUN, RPS27A
16MyD88-independent toll-like receptor signaling pathwayGO:00275610.1RPS27A, JUN, NFKB1
17positive regulation of neuron apoptotic processGO:04352510.1JUN, CCL3, FASLG
18interferon-gamma-mediated signaling pathwayGO:06033310.1HLA-B, HLA-C, HLA-A
19type I interferon-mediated signaling pathwayGO:06033710.1HLA-A, HLA-B, HLA-C
20toll-like receptor 3 signaling pathwayGO:03413810.1RPS27A, JUN, NFKB1
21MyD88-dependent toll-like receptor signaling pathwayGO:00275510.0RPS27A, JUN, NFKB1
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.0RPS27A, HLA-C, HLA-B, HLA-A
23macrophage chemotaxisGO:0482469.9CX3CR1, CCL3
24antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.9RPS27A, HLA-C, HLA-B, HLA-A
25antigen processing and presentation of peptide antigen via MHC class IGO:0024749.9RPS27A, HLA-C, HLA-B, HLA-A
26cytokine-mediated signaling pathwayGO:0192219.9HLA-A, HLA-B, HLA-C, RPS27A
27negative regulation by host of viral transcriptionGO:0439229.9CCL3, JUN
28response to toxic substanceGO:0096369.8CCL3, MBP, FAS
29positive regulation of apoptotic processGO:0430659.8RPS27A, FAS, FASLG, IL2RA
30regulation of immune responseGO:0507769.6HLA-C, HLA-B, HLA-A
31negative regulation of transcription from RNA polymerase II promoterGO:0001229.6RPS27A, FASLG, NFKB1, MYC, VDR, GLI2
32negative regulation of apoptotic processGO:0430669.6RPS27A, FAS, NFKB1, MYC, CX3CR1, IL2
33toll-like receptor 4 signaling pathwayGO:0341429.6RPS27A, JUN, NFKB1
34apoptotic processGO:0069159.4RPS27A, PDCD1, FAS, FASLG, NFKB1, GLI2
35positive regulation of transcription from RNA polymerase II promoterGO:0459449.4RPS27A, JUN, NFKB1, MYC, VDR, GLI2
36immune responseGO:0069558.9IL2, MBP, FASLG, HLA-C, HLA-B, HLA-A

Molecular functions related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426059.6HLA-A, HLA-B, HLA-C
2receptor bindingGO:0051029.6HLA-A, HLA-B, HLA-C, FASLG
3protein bindingGO:0055157.1JUN, CCL3, PDCD1, MBP, FAS, FASLG

Products for genes affiliated with Htlv-1 Associated Myelopathy

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3CDC
13ExPASy
14FMA
22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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39NCIt
40NDF-RT
43NINDS
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50PubMed
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