MCID: HTL002
MIFTS: 39

Htlv-1 Associated Myelopathy malady

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Summaries for Htlv-1 Associated Myelopathy

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NINDS:43 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes

MalaCards based summary: Htlv-1 Associated Myelopathy, also known as myelopathy, htlv-1-associated, is related to thyroiditis and multiple sclerosis. An important gene associated with Htlv-1 Associated Myelopathy is CX3CR1 (chemokine (C-X3-C motif) receptor 1), and among its related pathways are TNF Signaling and Apoptosis. The compounds ccl3 and imiquimod have been mentioned in the context of this disorder. Affiliated tissues include t cells, spinal cord and brain, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Htlv-1 Associated Myelopathy

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Sources:
62UMLS, 43NINDS, 44Novoseek
See all sources

Htlv-1 Associated Myelopathy, Aliases & Descriptions:

Name: Htlv-1 Associated Myelopathy 43
Myelopathy, Htlv-1-Associated 44
 
Tropical Spastic Paraparesis 62


Related Diseases for Htlv-1 Associated Myelopathy

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Diseases related to Htlv-1 Associated Myelopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.6IFNA1, FASLG
2multiple sclerosis30.5IFNA1, CX3CR1, FASLG
3t-cell leukemia30.4FASLG, FAS
4leukemia30.2FAS, FASLG, IFNA1
5tropical spastic paraparesis11.0
6htlv-1 associated myelopathy/tropical spastic paraparesis11.0
7spastic paraparesis11.0
8spasticity11.0
9dermatitis10.5
10infective dermatitis associated with htlv-110.5
11adult t-cell leukemia10.2
12hypertension10.2
13paroxysmal nocturnal hemoglobinuria10.2
14hemoglobinuria10.2
15lepromatous leprosy10.2
16amyloidosis10.2
17leprosy10.2
18neuropathy10.2
19peripheral neuropathy10.2
20neurologic diseases10.2
21autonomic dysfunction10.2
22hypersensitivity reaction type ii disease10.1IFNA1, FASLG
23splenomegaly10.1FAS, IFNA1
24autoimmune hepatitis10.0FAS, IFNA1
25cutaneous t cell lymphoma10.0FAS, IFNA1
26toxic epidermal necrolysis10.0FAS, FASLG
27vogt-koyanagi-harada disease10.0FASLG, FAS
28silicosis10.0FASLG, FAS
29lymphomatoid papulosis10.0FAS, FASLG
30stevens-johnson syndrome10.0FAS, FASLG
31autoimmune lymphoproliferative syndrome10.0FAS, FASLG
32hepatitis c10.0IFNA1, FAS
33aplastic anemia10.0FAS, FASLG
34lymphopenia10.0FAS, FASLG
35autoimmune thyroiditis10.0FASLG, FAS
36graft versus host disease10.0FASLG, FAS
37sjogren's syndrome10.0FAS, FASLG
38thyroid hurthle cell carcinoma10.0FAS, FASLG
39hepatitis10.0FASLG, IFNA1
40chronic lymphocytic leukemia10.0FAS, FASLG
41graves' disease10.0FAS, FASLG
42gastric adenocarcinoma9.9FAS, FASLG
43colon adenocarcinoma9.9FASLG, FAS
44myelodysplastic syndromes9.9FAS, FASLG
45non-small cell lung carcinoma9.9FASLG, FAS
46pancreatic cancer9.9FAS, FASLG
47malignant glioma9.9FASLG, FAS
48stomach cancer9.8FASLG, FAS
49viral hepatitis9.8FASLG, FAS, IFNA1
50myeloma9.8IFNA1, FAS, FASLG

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy:



Diseases related to htlv-1 associated myelopathy

Symptoms for Htlv-1 Associated Myelopathy

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Drugs & Therapeutics for Htlv-1 Associated Myelopathy

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Drug clinical trials:

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Genetic Tests for Htlv-1 Associated Myelopathy

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Anatomical Context for Htlv-1 Associated Myelopathy

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MalaCards organs/tissues related to Htlv-1 Associated Myelopathy:

32
T cells, Spinal cord, Brain, Liver, Thyroid, B cells

Animal Models for Htlv-1 Associated Myelopathy or affiliated genes

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MGI Mouse Phenotypes related to Htlv-1 Associated Myelopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5FAS, FASLG, CX3CR1
2MP:00107718.5FASLG, FAS, CX3CR1
3MP:00053818.4CX3CR1, FASLG, FAS
4MP:00053918.2CX3CR1, FAS, FASLG

Publications for Htlv-1 Associated Myelopathy

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Articles related to Htlv-1 Associated Myelopathy:

(show all 47)
idTitleAuthorsYear
1
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. (24472094)
2014
2
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (25227931)
2014
3
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. (23278610)
2013
4
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. (23932323)
2013
5
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. (22720101)
2012
6
Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy. (22291590)
2012
7
Aquaporin-4 antibodies are not related to HTLV-1 associated myelopathy. (22808032)
2012
8
Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects. (22405461)
2012
9
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
10
HTLV-1 associated myelopathy/tropical spastic paraparesis: how far have we come? (22519224)
2011
11
Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina. (20572090)
2010
12
Sphincter abnormality in polytransfused patient due to paroxysmal nocturnal hemoglobinuria (PNH): initial manifestation of tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM). (21243260)
2010
13
Case report of HTLV-1 associated myelopathy (HAM) manifested after renal transplantation]. (20411806)
2010
14
Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population. (20851016)
2010
15
Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). (20169122)
2010
16
HTLV-1 associated myelopathy diagnosed during lepromatous leprosy reaction treatment: a case report. (20802953)
2010
17
A 15-year prospective longitudinal study of disease progression in patients with HTLV-1 associated myelopathy in the UK. (20660921)
2010
18
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (19228429)
2009
19
Is human T cell lymphotropic type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) syndrome a neglected disease? (19936247)
2009
20
Evaluation of autonomic malfunction in HTLV-1 associated myelopathy (HAM). (19553162)
2009
21
High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. (19578703)
2009
22
Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease. (17884099)
2008
23
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. (17717136)
2007
24
Nocturnal hypertension and autonomic dysfunction due to human T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (16503269)
2006
25
Human T-cell lymphotropic virus type I (HTLV-1) associated myelopathy and SjAPgren's syndrome representing pulmonary nodular amyloidosis and multiple bullae: Report of an autopsy case. (16609913)
2006
26
Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. (17034574)
2006
27
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. (15961107)
2005
28
Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. (15722539)
2005
29
Human T lymphotropic virus type I (HTLV-1) associated myelopathy acquired through a liver transplant. (11762319)
2001
30
Chemokines in chronic progressive neurological diseases: HTLV-1 associated myelopathy and multiple sclerosis. (10190696)
1999
31
Predominant expression of Fas ligand mRNA in CD8+ T lymphocytes in patients with HTLV-1 associated myelopathy. (9817448)
1998
32
Cerebrospinal fluid of HTLV-1 associated myelopathy patients induces axonal sproutings and Schwann cell proliferation in the rat sciatic nerve. (9700698)
1998
33
Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy. (9671316)
1998
34
HTLV-1 associated myelopathy/tropical spastic paraparesis in Egypt. (8912212)
1996
35
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis. (8555734)
1995
36
Cognitive event-related potentials and brain magnetic resonance imaging in HTLV-1 associated myelopathy (HAM). (7836944)
1994
37
Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil. (8372632)
1993
38
Danazol. A new perspective in the treatment of HTLV-1 associated myelopathy (preliminary report). (1308424)
1992
39
HTLV-1 associated myelopathy/tropical spastic paraparesis with adult T-cell leukemia. (1736016)
1992
40
Post-mortem diagnosis of human T lymphotrophic virus type-1 (HTLV-1) associated myelopathy by detection of HTLV-1 DNA in the spinal cord of a patient with post-transfusional myelopathy. (1791859)
1991
41
HTLV-1 associated myelopathy combined with chronic thyroiditis. (2066716)
1991
42
High ratio of HTLV-1-infected cells in HTLV-1 associated myelopathy (HAM). (2353570)
1990
43
HTLV-1 associated myelopathy in Chile. (2311023)
1990
44
HTLV-1 associated myelopathy in Canada. (2766126)
1989
45
Central motor conduction time in patients with HTLV-1 associated myelopathy. (2741672)
1989
46
HTLV-1 associated myelopathy in an HTLV-1 and HBV double carrier family: report of a case and the mode of vertical transmission of both viruses. (2491206)
1989
47
HTLV-1 associated myelopathy (HAM). (2901451)
1988

Variations for Htlv-1 Associated Myelopathy

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Expression for genes affiliated with Htlv-1 Associated Myelopathy

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Expression patterns in normal tissues for genes affiliated with Htlv-1 Associated Myelopathy

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Pathways for genes affiliated with Htlv-1 Associated Myelopathy

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Pathways related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0FASLG, FAS
2
Show member pathways
9.0FASLG, FAS
3
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.0FAS, FASLG
4
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0FASLG, FAS
59.0FAS, FASLG
69.0FAS, FASLG
79.0FAS, FASLG
8
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0FASLG, FAS
99.0FAS, FASLG
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.0FASLG, FAS
11
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.0FAS, FASLG
12
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.0FASLG, FAS
13
Show member pathways
9.0FASLG, FAS
149.0FAS, FASLG
15
Show member pathways
9.0FAS, FASLG
16
Show member pathways
TRAIL signaling pathway37
9.0FASLG, FAS
179.0FAS, FASLG
18
Show member pathways
Immune response CD16 signaling in NK cells60
8.5IFNA1, FASLG, FAS
19
Show member pathways
8.5IFNA1, FASLG, FAS
20
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5IFNA1, FAS, FASLG
21
Show member pathways
8.5FASLG, IFNA1, FAS
22
Show member pathways
8.0CX3CR1, FAS, FASLG, IFNA1

Compounds for genes affiliated with Htlv-1 Associated Myelopathy

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Compounds related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1ccl344 2810.7CX3CR1, IFNA1
2imiquimod44 61 28 1112.7FASLG, IFNA1
3mitoxantrone44 50 1111.7IFNA1, FASLG
4leucovorin44 50 1111.7FASLG, IFNA1
5rituximab44 50 1111.6IFNA1, FASLG
6(glc)4449.5FAS, FASLG
7concanamycin a44 6110.4FAS, FASLG
8thalidomide44 50 61 1112.4FASLG, IFNA1
93-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.4FASLG, FAS
10dutp449.4FASLG, FAS
11depsipeptide449.4FAS, FASLG
12suberoylanilide hydroxamic acid449.4FAS, FASLG
13ivig449.3FAS, FASLG
14calyculin a44 61 1111.3FAS, FASLG
15c2ceramide449.3FASLG, FAS
16rottlerin449.3FASLG, FAS
17daunorubicin44 50 1111.3FAS, FASLG
18ag 1478449.2FAS, FASLG
19tetracycline44 1110.2FAS, FASLG
20anisomycin44 1110.1FASLG, FAS
21adpribose449.0FAS, FASLG
22morphine44 50 28 1112.0FASLG, FAS
23atpo28 4410.0IFNA1, FASLG, FAS
24teniposide44 1110.0FASLG, IFNA1, FAS
252-chlorodeoxyadenosine449.0FASLG, IFNA1, FAS
26fludarabine44 50 1111.0FAS, FASLG, IFNA1
27ifn-alpha448.9FAS, IFNA1, FASLG
28thymidylate448.9IFNA1, FASLG, FAS
29cytarabine44 50 1110.9IFNA1, FASLG, FAS
30adriamycin448.9IFNA1, FAS, FASLG
31camptothecin44 61 1110.9FAS, IFNA1, FASLG
32mitomycin c448.9FASLG, FAS
335-aza-2deoxycytidine448.9FASLG, IFNA1, FAS
34arsenite44 249.9IFNA1, FASLG, FAS
355fluorouracil448.9FAS, FASLG, IFNA1
36etoposide44 50 61 1111.9FAS, FASLG, IFNA1
37tamoxifen44 50 28 1111.9FASLG, FAS, IFNA1
38rapamycin448.9IFNA1, FAS, FASLG
39doxorubicin44 50 1110.9IFNA1, FAS, FASLG
40actinomycin d448.9FASLG, IFNA1, FAS
41cyclosporin a44 28 6110.9FASLG, IFNA1, FAS
42thymidine44 249.9IFNA1, FAS, FASLG
43cisplatin44 50 61 1111.9IFNA1, FAS, FASLG
44aspartate448.9FASLG, FAS, IFNA1
45cycloheximide448.9FASLG, FAS, IFNA1
46dexamethasone44 50 28 1111.8IFNA1, FASLG, FAS
47sp 60012544 619.7FAS, FASLG
48phosphatidylinositol448.7CX3CR1, FASLG, FAS
49rantes448.4CX3CR1, IFNA1, FASLG, FAS
50vegf448.4CX3CR1, IFNA1, FASLG, FAS

GO Terms for genes affiliated with Htlv-1 Associated Myelopathy

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Cellular components related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0FASLG, FAS

Biological processes related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of angiogenesisGO:0165259.2FASLG, CX3CR1
2inflammatory cell apoptotic processGO:0069259.2FASLG, FAS
3necroptotic signaling pathwayGO:0975279.2FASLG, FAS
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.1FAS, FASLG
5extrinsic apoptotic signaling pathwayGO:0971919.1FASLG, FAS
6extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.0FAS, FASLG
7apoptotic signaling pathwayGO:0971909.0FAS, FASLG
8activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069198.7FASLG, FAS

Products for genes affiliated with Htlv-1 Associated Myelopathy

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Sources for Htlv-1 Associated Myelopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet