MCID: HTL002
MIFTS: 36

Htlv-1 Associated Myelopathy malady

Summaries for Htlv-1 Associated Myelopathy

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NINDS:42 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes

MalaCards based summary: Htlv-1 Associated Myelopathy, also known as myelopathy, htlv-1-associated, is related to thyroiditis and t-cell leukemia, and has symptoms including abnormality of metabolism/homeostasis, morphological abnormality of the pyramidal tract and myelopathy. An important gene associated with Htlv-1 Associated Myelopathy is CX3CR1 (chemokine (C-X3-C motif) receptor 1), and among its related pathways are TNF Signaling and Apoptosis. The compounds ccl3 and imiquimod have been mentioned in the context of this disorder. Affiliated tissues include t cells, spinal cord and brain, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Htlv-1 Associated Myelopathy

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Sources:
60UMLS, 42NINDS, 43Novoseek
See all sources

Htlv-1 Associated Myelopathy, Aliases & Descriptions:

Name: Htlv-1 Associated Myelopathy 42
Myelopathy, Htlv-1-Associated 43
 
Tropical Spastic Paraparesis 60


Related Diseases for Htlv-1 Associated Myelopathy

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Diseases related to Htlv-1 Associated Myelopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.6IFNA1, FASLG
2t-cell leukemia30.5FAS, FASLG
3leukemia30.2FAS, FASLG, IFNA1
4htlv-1 associated myelopathy/tropical spastic paraparesis11.0
5tropical spastic paraparesis11.0
6spastic paraparesis11.0
7spasticity11.0
8dermatitis10.5
9infective dermatitis associated with htlv-110.5
10leprosy10.2
11adult t-cell leukemia10.2
12paroxysmal nocturnal hemoglobinuria10.2
13lepromatous leprosy10.2
14amyloidosis10.2
15hemoglobinuria10.2
16myopathy10.2
17neuropathy10.2
18peripheral neuropathy10.2
19neurologic diseases10.2
20human t-cell leukemia virus type 110.2
21polymyositis10.2
22autonomic dysfunction10.2
23hypersensitivity reaction type ii disease10.1IFNA1, FASLG
24splenomegaly10.0IFNA1, FAS
25autoimmune hepatitis10.0IFNA1, FAS
26cutaneous t cell lymphoma10.0FAS, IFNA1
27vogt-koyanagi-harada disease10.0FAS, FASLG
28silicosis10.0FASLG, FAS
29lymphomatoid papulosis10.0FAS, FASLG
30hypersensitivity syndrome, carbamazepine-induced10.0FASLG, FAS
31autoimmune lymphoproliferative syndrome10.0FAS, FASLG
32hepatitis c10.0FAS, IFNA1
33aplastic anemia10.0FASLG, FAS
34lymphopenia10.0FAS, FASLG
35hashimoto thyroiditis10.0FAS, FASLG
36graft-versus-host disease, protection against10.0FASLG, FAS
37sjogren's syndrome10.0FAS, FASLG
38thyroid cancer10.0FAS, FASLG
39chronic lymphocytic leukemia10.0FAS, FASLG
40graves' disease9.9FASLG, FAS
41gastric adenocarcinoma9.9FASLG, FAS
42colon adenocarcinoma9.9FASLG, FAS
43myelodysplastic syndrome9.9FASLG, FAS
44hepatitis9.9FASLG, IFNA1
45multiple sclerosis, disease progression, modifier of9.9FASLG, CX3CR1, IFNA1
46lung cancer9.9FASLG, FAS
47pancreatic cancer9.9FASLG, FAS
48malignant glioma9.9FASLG, FAS
49stomach cancer9.8FASLG, FAS
50viral hepatitis9.8FAS, FASLG, IFNA1

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy:



Diseases related to htlv-1 associated myelopathy

Symptoms for Htlv-1 Associated Myelopathy

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HPO human phenotypes related to Htlv-1 Associated Myelopathy:

id Description Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis HP:0001939
2 morphological abnormality of the pyramidal tract HP:0002062
3 myelopathy HP:0002196
4 tropical spastic paraparesis HP:0007191

Drugs & Therapeutics for Htlv-1 Associated Myelopathy

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Drug clinical trials:

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Search NIH Clinical Center for Htlv-1 Associated Myelopathy

Genetic Tests for Htlv-1 Associated Myelopathy

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Anatomical Context for Htlv-1 Associated Myelopathy

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MalaCards organs/tissues related to Htlv-1 Associated Myelopathy:

31
T cells, Spinal cord, Brain, Liver, Thyroid, B cells

Animal Models for Htlv-1 Associated Myelopathy or affiliated genes

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MGI Mouse Phenotypes related to Htlv-1 Associated Myelopathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5CX3CR1, FASLG, FAS
2MP:00107718.5CX3CR1, FASLG, FAS
3MP:00053818.4CX3CR1, FASLG, FAS
4MP:00053918.2FAS, FASLG, CX3CR1

Publications for Htlv-1 Associated Myelopathy

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Articles related to Htlv-1 Associated Myelopathy:

(show all 50)
idTitleAuthorsYear
1
Donor-Derived HTLV-1 Associated Myelopathy After Transplantation: A Call for Targeted Screening. (25772487)
2015
2
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (25884435)
2015
3
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. (24472094)
2014
4
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (25227931)
2014
5
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. (23278610)
2013
6
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. (23932323)
2013
7
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. (22720101)
2012
8
Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy. (22291590)
2012
9
Aquaporin-4 antibodies are not related to HTLV-1 associated myelopathy. (22808032)
2012
10
Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects. (22405461)
2012
11
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
12
HTLV-1 associated myelopathy/tropical spastic paraparesis: how far have we come? (22519224)
2011
13
Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina. (20572090)
2010
14
Sphincter abnormality in polytransfused patient due to paroxysmal nocturnal hemoglobinuria (PNH): initial manifestation of tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM). (21243260)
2010
15
Case report of HTLV-1 associated myelopathy (HAM) manifested after renal transplantation]. (20411806)
2010
16
Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population. (20851016)
2010
17
Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). (20169122)
2010
18
HTLV-1 associated myelopathy diagnosed during lepromatous leprosy reaction treatment: a case report. (20802953)
2010
19
A 15-year prospective longitudinal study of disease progression in patients with HTLV-1 associated myelopathy in the UK. (20660921)
2010
20
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (19228429)
2009
21
Is human T cell lymphotropic type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) syndrome a neglected disease? (19936247)
2009
22
Evaluation of autonomic malfunction in HTLV-1 associated myelopathy (HAM). (19553162)
2009
23
High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. (19578703)
2009
24
Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease. (17884099)
2008
25
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. (17717136)
2007
26
Nocturnal hypertension and autonomic dysfunction due to human T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (16503269)
2006
27
Human T-cell lymphotropic virus type I (HTLV-1) associated myelopathy and SjAPgren's syndrome representing pulmonary nodular amyloidosis and multiple bullae: Report of an autopsy case. (16609913)
2006
28
Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. (17034574)
2006
29
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. (15961107)
2005
30
Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. (15722539)
2005
31
Human T lymphotropic virus type I (HTLV-1) associated myelopathy acquired through a liver transplant. (11762319)
2001
32
Chemokines in chronic progressive neurological diseases: HTLV-1 associated myelopathy and multiple sclerosis. (10190696)
1999
33
Predominant expression of Fas ligand mRNA in CD8+ T lymphocytes in patients with HTLV-1 associated myelopathy. (9817448)
1998
34
Cerebrospinal fluid of HTLV-1 associated myelopathy patients induces axonal sproutings and Schwann cell proliferation in the rat sciatic nerve. (9700698)
1998
35
Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy. (9671316)
1998
36
CD8 and CD4 T cell-mediated polymyositis complicating the HTLV-1 associated myelopathy. Quantitative evaluation of corticosteroid treatment. (8891056)
1996
37
HTLV-1 associated myelopathy/tropical spastic paraparesis in Egypt. (8912212)
1996
38
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis. (8555734)
1995
39
Cognitive event-related potentials and brain magnetic resonance imaging in HTLV-1 associated myelopathy (HAM). (7836944)
1994
40
Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil. (8372632)
1993
41
Danazol. A new perspective in the treatment of HTLV-1 associated myelopathy (preliminary report). (1308424)
1992
42
HTLV-1 associated myelopathy/tropical spastic paraparesis with adult T-cell leukemia. (1736016)
1992
43
Post-mortem diagnosis of human T lymphotrophic virus type-1 (HTLV-1) associated myelopathy by detection of HTLV-1 DNA in the spinal cord of a patient with post-transfusional myelopathy. (1791859)
1991
44
HTLV-1 associated myelopathy combined with chronic thyroiditis. (2066716)
1991
45
High ratio of HTLV-1-infected cells in HTLV-1 associated myelopathy (HAM). (2353570)
1990
46
HTLV-1 associated myelopathy in Chile. (2311023)
1990
47
HTLV-1 associated myelopathy in Canada. (2766126)
1989
48
Central motor conduction time in patients with HTLV-1 associated myelopathy. (2741672)
1989
49
HTLV-1 associated myelopathy in an HTLV-1 and HBV double carrier family: report of a case and the mode of vertical transmission of both viruses. (2491206)
1989
50
HTLV-1 associated myelopathy (HAM). (2901451)
1988

Variations for Htlv-1 Associated Myelopathy

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Expression for genes affiliated with Htlv-1 Associated Myelopathy

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Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy.

Pathways for genes affiliated with Htlv-1 Associated Myelopathy

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Pathways related to Htlv-1 Associated Myelopathy according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0FAS, FASLG
2
Show member pathways
9.0FASLG, FAS
3
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.0FASLG, FAS
4
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.0FAS, FASLG
59.0FASLG, FAS
6
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.0FAS, FASLG
79.0FASLG, FAS
8
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.0FASLG, FAS
99.0FASLG, FAS
109.0FAS, FASLG
11
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.0FASLG, FAS
12
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
9.0FASLG, FAS
13
Show member pathways
9.0FASLG, FAS
149.0FASLG, FAS
15
Show member pathways
9.0FAS, FASLG
16
Show member pathways
TRAIL signaling pathway36
9.0FAS, FASLG
179.0FASLG, FAS
18
Show member pathways
8.5IFNA1, FASLG, FAS
19
Show member pathways
8.5IFNA1, FASLG, FAS
20
Show member pathways
Immune response CD16 signaling in NK cells58
8.5FAS, FASLG, IFNA1
21
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.5FAS, FASLG, IFNA1
22
Show member pathways
8.0IFNA1, CX3CR1, FASLG, FAS

Compounds for genes affiliated with Htlv-1 Associated Myelopathy

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Compounds related to Htlv-1 Associated Myelopathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1ccl343 2810.7CX3CR1, IFNA1
2imiquimod43 59 28 1212.7IFNA1, FASLG
3mitoxantrone43 49 1211.7FASLG, IFNA1
4leucovorin43 49 1211.7IFNA1, FASLG
5rituximab43 49 1211.6IFNA1, FASLG
6(glc)4439.5FAS, FASLG
7concanamycin a43 5910.4FAS, FASLG
8thalidomide43 49 59 1212.4IFNA1, FASLG
9dutp439.4FAS, FASLG
103-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.4FAS, FASLG
11depsipeptide439.4FAS, FASLG
12suberoylanilide hydroxamic acid439.4FASLG, FAS
13ivig439.3FASLG, FAS
14calyculin a43 59 1211.3FASLG, FAS
15c2ceramide439.3FASLG, FAS
16rottlerin439.3FASLG, FAS
17daunorubicin43 49 1211.3FASLG, FAS
18ag 1478439.2FASLG, FAS
19tetracycline43 1210.2FASLG, FAS
20anisomycin43 1210.1FASLG, FAS
21adpribose439.0FAS, FASLG
22morphine43 49 28 1212.0FASLG, FAS
23atpo28 4310.0IFNA1, FASLG, FAS
24teniposide43 1210.0IFNA1, FASLG, FAS
252-chlorodeoxyadenosine439.0IFNA1, FASLG, FAS
26fludarabine43 49 1211.0IFNA1, FASLG, FAS
27ifn-alpha438.9FAS, FASLG, IFNA1
28thymidylate438.9IFNA1, FASLG, FAS
29cytarabine43 49 1210.9IFNA1, FASLG, FAS
30adriamycin438.9IFNA1, FASLG, FAS
31camptothecin43 59 1210.9FAS, FASLG, IFNA1
32mitomycin c438.9FASLG, FAS
335-aza-2deoxycytidine438.9IFNA1, FASLG, FAS
34arsenite43 249.9FAS, FASLG, IFNA1
355fluorouracil438.9IFNA1, FASLG, FAS
36etoposide43 49 59 1211.9IFNA1, FASLG, FAS
37tamoxifen43 49 28 1211.9FAS, FASLG, IFNA1
38rapamycin438.9IFNA1, FASLG, FAS
39doxorubicin43 49 1210.9FAS, FASLG, IFNA1
40actinomycin d438.9IFNA1, FASLG, FAS
41cyclosporin a43 28 5910.9IFNA1, FASLG, FAS
42thymidine43 249.9IFNA1, FASLG, FAS
43cisplatin43 49 59 1211.9FAS, FASLG, IFNA1
44aspartate438.9IFNA1, FASLG, FAS
45cycloheximide438.9IFNA1, FASLG, FAS
46dexamethasone43 49 28 1211.8FAS, FASLG, IFNA1
47sp 60012543 599.7FASLG, FAS
48phosphatidylinositol438.7FAS, FASLG, CX3CR1
49rantes438.4FAS, FASLG, CX3CR1, IFNA1
50vegf438.4FAS, FASLG, CX3CR1, IFNA1

GO Terms for genes affiliated with Htlv-1 Associated Myelopathy

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Cellular components related to Htlv-1 Associated Myelopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0FASLG, FAS

Biological processes related to Htlv-1 Associated Myelopathy according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of angiogenesisGO:00165259.2CX3CR1, FASLG
2inflammatory cell apoptotic processGO:00069259.2FASLG, FAS
3necroptotic signaling pathwayGO:00975279.2FASLG, FAS
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012399.1FASLG, FAS
5extrinsic apoptotic signaling pathwayGO:00971919.1FAS, FASLG
6extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.0FAS, FASLG
7apoptotic signaling pathwayGO:00971909.0FASLG, FAS
8activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069198.7FASLG, FAS

Products for genes affiliated with Htlv-1 Associated Myelopathy

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Sources for Htlv-1 Associated Myelopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet