MCID: HTL002
MIFTS: 39

Htlv-1 Associated Myelopathy malady

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Summaries for Htlv-1 Associated Myelopathy

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44NINDS, 33MalaCards
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NINDS:44 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes

MalaCards: Htlv-1 Associated Myelopathy, also known as myelopathy, htlv-1-associated, is related to t-cell leukemia and leukemia. An important gene associated with Htlv-1 Associated Myelopathy is CX3CR1 (chemokine (C-X3-C motif) receptor 1), and among its related pathways are TNF Signaling and Apoptosis. The compounds ccl3 and imiquimod have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Htlv-1 Associated Myelopathy

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62UMLS, 44NINDS, 45Novoseek
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Aliases & Descriptions:

htlv-1 associated myelopathy 44
myelopathy, htlv-1-associated 45
tropical spastic paraparesis 62


Related Diseases for Htlv-1 Associated Myelopathy

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17GeneCards, 18GeneDecks
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Diseases related to Htlv-1 Associated Myelopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1t-cell leukemia30.5FAS, FASLG
2leukemia30.5FAS, FASLG, IFNA1
3thyroiditis30.4IFNA1, FASLG
4multiple sclerosis30.3FASLG, CX3CR1, IFNA1
5htlv-1 associated myelopathy/tropical spastic paraparesis10.9
6tropical spastic paraparesis10.9
7spastic paraparesis10.9
8spasticity10.9
9dermatitis10.5
10infective dermatitis associated with htlv-110.5
11lepromatous leprosy10.2
12hemoglobinuria10.2
13adult t-cell leukemia10.2
14amyloidosis10.2
15hypertension10.2
16leprosy10.2
17neuropathy10.2
18peripheral neuropathy10.2
19neurologic diseases10.2
20paroxysmal nocturnal hemoglobinuria10.2
21polymyositis10.2
22autonomic dysfunction10.2
23hypersensitivity reaction type ii disease10.0IFNA1, FASLG
24splenomegaly10.0IFNA1, FAS
25autoimmune hepatitis10.0IFNA1, FAS
26cutaneous t cell lymphoma10.0FAS, IFNA1
27vogt-koyanagi-harada disease10.0FAS, FASLG
28toxic epidermal necrolysis10.0FAS, FASLG
29silicosis10.0FASLG, FAS
30lymphomatoid papulosis10.0FAS, FASLG
31stevens-johnson syndrome10.0FASLG, FAS
32autoimmune lymphoproliferative syndrome10.0FAS, FASLG
33hepatitis c10.0FAS, IFNA1
34aplastic anemia10.0FASLG, FAS
35lymphopenia10.0FAS, FASLG
36autoimmune thyroiditis10.0FAS, FASLG
37graft versus host disease10.0FASLG, FAS
38sjogren's syndrome10.0FAS, FASLG
39thyroid cancer10.0FAS, FASLG
40b-cell chronic lymphocytic leukemia10.0FAS, FASLG
41graves' disease10.0FASLG, FAS
42gastric adenocarcinoma10.0FASLG, FAS
43colon adenocarcinoma10.0FASLG, FAS
44myelodysplastic syndromes10.0FASLG, FAS
45hepatitis10.0FASLG, IFNA1
46non-small cell lung carcinoma10.0FASLG, FAS
47pancreatic cancer10.0FASLG, FAS
48malignant glioma10.0FASLG, FAS
49stomach cancer10.0FASLG, FAS
50viral hepatitis10.0FAS, FASLG, IFNA1

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy:



Diseases related to htlv-1 associated myelopathy

Symptoms for Htlv-1 Associated Myelopathy

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Drugs & Therapeutics for Htlv-1 Associated Myelopathy

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Htlv-1 Associated Myelopathy

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Anatomical Context for Htlv-1 Associated Myelopathy

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33MalaCards
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MalaCards organs/tissues related to Htlv-1 Associated Myelopathy:

33
T cells, Brain, Spinal cord, Liver, Thyroid

Animal Models for Htlv-1 Associated Myelopathy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Htlv-1 Associated Myelopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5FAS, FASLG, CX3CR1
2MP:00107718.5FASLG, FAS, CX3CR1
3MP:00053818.4CX3CR1, FASLG, FAS
4MP:00053918.2CX3CR1, FAS, FASLG

Publications for Htlv-1 Associated Myelopathy

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52PubMed
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Articles related to Htlv-1 Associated Myelopathy:

(show all 44)
idTitleAuthorsYear
1
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. (23278610)
2013
2
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. (23932323)
2013
3
Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy. (22291590)
2012
4
Aquaporin-4 antibodies are not related to HTLV-1 associated myelopathy. (22808032)
2012
5
Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects. (22405461)
2012
6
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
7
HTLV-1 associated myelopathy/tropical spastic paraparesis: how far have we come? (22519224)
2011
8
Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina. (20572090)
2010
9
Sphincter abnormality in polytransfused patient due to paroxysmal nocturnal hemoglobinuria (PNH): initial manifestation of tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM). (21243260)
2010
10
Case report of HTLV-1 associated myelopathy (HAM) manifested after renal transplantation]. (20411806)
2010
11
Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population. (20851016)
2010
12
Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). (20169122)
2010
13
HTLV-1 associated myelopathy diagnosed during lepromatous leprosy reaction treatment: a case report. (20802953)
2010
14
A 15-year prospective longitudinal study of disease progression in patients with HTLV-1 associated myelopathy in the UK. (20660921)
2010
15
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (19228429)
2009
16
Is human T cell lymphotropic type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) syndrome a neglected disease? (19936247)
2009
17
Evaluation of autonomic malfunction in HTLV-1 associated myelopathy (HAM). (19553162)
2009
18
High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. (19578703)
2009
19
Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease. (17884099)
2008
20
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. (17717136)
2007
21
Nocturnal hypertension and autonomic dysfunction due to human T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (16503269)
2006
22
Human T-cell lymphotropic virus type I (HTLV-1) associated myelopathy and SjAPgren's syndrome representing pulmonary nodular amyloidosis and multiple bullae: Report of an autopsy case. (16609913)
2006
23
Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. (17034574)
2006
24
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. (15961107)
2005
25
Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. (15722539)
2005
26
Human T lymphotropic virus type I (HTLV-1) associated myelopathy acquired through a liver transplant. (11762319)
2001
27
Chemokines in chronic progressive neurological diseases: HTLV-1 associated myelopathy and multiple sclerosis. (10190696)
1999
28
Predominant expression of Fas ligand mRNA in CD8+ T lymphocytes in patients with HTLV-1 associated myelopathy. (9817448)
1998
29
Cerebrospinal fluid of HTLV-1 associated myelopathy patients induces axonal sproutings and Schwann cell proliferation in the rat sciatic nerve. (9700698)
1998
30
CD8 and CD4 T cell-mediated polymyositis complicating the HTLV-1 associated myelopathy. Quantitative evaluation of corticosteroid treatment. (8891056)
1996
31
HTLV-1 associated myelopathy/tropical spastic paraparesis in Egypt. (8912212)
1996
32
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis. (8555734)
1995
33
Cognitive event-related potentials and brain magnetic resonance imaging in HTLV-1 associated myelopathy (HAM). (7836944)
1994
34
Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil. (8372632)
1993
35
Danazol. A new perspective in the treatment of HTLV-1 associated myelopathy (preliminary report). (1308424)
1992
36
HTLV-1 associated myelopathy/tropical spastic paraparesis with adult T-cell leukemia. (1736016)
1992
37
Post-mortem diagnosis of human T lymphotrophic virus type-1 (HTLV-1) associated myelopathy by detection of HTLV-1 DNA in the spinal cord of a patient with post-transfusional myelopathy. (1791859)
1991
38
HTLV-1 associated myelopathy combined with chronic thyroiditis. (2066716)
1991
39
High ratio of HTLV-1-infected cells in HTLV-1 associated myelopathy (HAM). (2353570)
1990
40
HTLV-1 associated myelopathy in Chile. (2311023)
1990
41
HTLV-1 associated myelopathy in Canada. (2766126)
1989
42
Central motor conduction time in patients with HTLV-1 associated myelopathy. (2741672)
1989
43
HTLV-1 associated myelopathy in an HTLV-1 and HBV double carrier family: report of a case and the mode of vertical transmission of both viruses. (2491206)
1989
44
HTLV-1 associated myelopathy (HAM). (2901451)
1988

Variations for Htlv-1 Associated Myelopathy

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Expression for genes affiliated with Htlv-1 Associated Myelopathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Htlv-1 Associated Myelopathy

Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy.

Pathways for genes affiliated with Htlv-1 Associated Myelopathy

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50PathCards, 57SinoBiological, 54R&D Systems, 55Reactome, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 5Cell Signaling Technology
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Pathways related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0FASLG, FAS
2
Show member pathways
9.0FASLG, FAS
3
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.0FAS, FASLG
4
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0FASLG, FAS
59.0FAS, FASLG
69.0FAS, FASLG
79.0FAS, FASLG
8
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0FASLG, FAS
99.0FAS, FASLG
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.0FASLG, FAS
11
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.0FAS, FASLG
12
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.0FASLG, FAS
13
Show member pathways
9.0FASLG, FAS
149.0FAS, FASLG
15
Show member pathways
9.0FAS, FASLG
16
Show member pathways
TRAIL signaling pathway38
9.0FASLG, FAS
179.0FAS, FASLG
18
Show member pathways
Immune response CD16 signaling in NK cells60
8.5IFNA1, FASLG, FAS
19
Show member pathways
8.5IFNA1, FASLG, FAS
20
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.5IFNA1, FAS, FASLG
21
Show member pathways
8.5FASLG, IFNA1, FAS
22
Show member pathways
8.0CX3CR1, FAS, FASLG, IFNA1

Compounds for genes affiliated with Htlv-1 Associated Myelopathy

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45Novoseek, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 24HMDB
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Compounds related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1ccl345 2910.7CX3CR1, IFNA1
2imiquimod45 61 29 1112.7FASLG, IFNA1
3mitoxantrone45 51 1111.7IFNA1, FASLG
4leucovorin45 51 1111.7FASLG, IFNA1
5rituximab45 51 1111.6IFNA1, FASLG
6(glc)4459.5FAS, FASLG
7concanamycin a45 6110.4FAS, FASLG
8thalidomide45 51 61 1112.4FASLG, IFNA1
93-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.4FASLG, FAS
10dutp459.4FASLG, FAS
11depsipeptide459.4FAS, FASLG
12suberoylanilide hydroxamic acid459.4FAS, FASLG
13ivig459.3FAS, FASLG
14calyculin a45 61 1111.3FAS, FASLG
15c2ceramide459.3FASLG, FAS
16rottlerin459.3FASLG, FAS
17daunorubicin45 51 1111.3FAS, FASLG
18ag 1478459.2FAS, FASLG
19tetracycline45 1110.2FAS, FASLG
20anisomycin45 1110.1FASLG, FAS
21adpribose459.0FAS, FASLG
22morphine45 51 29 1112.0FASLG, FAS
23atpo29 4510.0IFNA1, FASLG, FAS
24teniposide45 1110.0FASLG, IFNA1, FAS
252-chlorodeoxyadenosine459.0FASLG, IFNA1, FAS
26fludarabine45 51 1111.0FAS, FASLG, IFNA1
27ifn-alpha458.9FAS, IFNA1, FASLG
28thymidylate458.9IFNA1, FASLG, FAS
29cytarabine45 51 1110.9IFNA1, FASLG, FAS
30adriamycin458.9IFNA1, FAS, FASLG
31camptothecin45 61 1110.9FAS, IFNA1, FASLG
32mitomycin c458.9FASLG, FAS
335-aza-2deoxycytidine458.9FASLG, IFNA1, FAS
34arsenite45 249.9IFNA1, FASLG, FAS
355fluorouracil458.9FAS, FASLG, IFNA1
36etoposide45 51 61 1111.9FAS, FASLG, IFNA1
37tamoxifen45 51 29 1111.9FASLG, FAS, IFNA1
38rapamycin458.9IFNA1, FAS, FASLG
39doxorubicin45 51 1110.9IFNA1, FAS, FASLG
40actinomycin d458.9FASLG, IFNA1, FAS
41cyclosporin a45 29 6110.9FASLG, IFNA1, FAS
42thymidine45 249.9IFNA1, FAS, FASLG
43cisplatin45 51 61 1111.9IFNA1, FAS, FASLG
44aspartate458.9FASLG, FAS, IFNA1
45cycloheximide458.9FASLG, FAS, IFNA1
46dexamethasone45 51 29 1111.8IFNA1, FASLG, FAS
47sp 60012545 619.7FAS, FASLG
48phosphatidylinositol458.7CX3CR1, FASLG, FAS
49rantes458.4CX3CR1, IFNA1, FASLG, FAS
50vegf458.4CX3CR1, IFNA1, FASLG, FAS

GO Terms for genes affiliated with Htlv-1 Associated Myelopathy

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16Gene Ontology
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Cellular components related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0FASLG, FAS

Biological processes related to Htlv-1 Associated Myelopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of angiogenesisGO:0165259.2CX3CR1, FASLG
2inflammatory cell apoptotic processGO:0069259.2FASLG, FAS
3necroptotic signaling pathwayGO:0975279.2FASLG, FAS
4regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.1FASLG, FAS
5extrinsic apoptotic signaling pathwayGO:0971919.1FAS, FASLG
6extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.0FAS, FASLG
7apoptotic signaling pathwayGO:0971909.0FASLG, FAS
8activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069198.7FASLG, FAS

Products for genes affiliated with Htlv-1 Associated Myelopathy

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Sources for Htlv-1 Associated Myelopathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet