MCID: HTL001
MIFTS: 38

Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis malady

Summaries for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Htlv-1 associated myelopathy/tropical spastic paraparesis (ham/tsp) is a chronic, progressive disease of the nervous system that affects less than 2 percent of people with htlv-1 infection. signs and symptoms vary but may include progressive weakness, stiff muscles, muscle spasms, backache, a 'weak' bladder, and constipation. the htlv-1 virus can be transmitted from mother to child via breastfeeding or childbirth, from person to person through sexual contact and through blood contact, either by transfusion or by reuse of injection equipment. htlv infection is not passed from person to person by coughing, sneezing, kissing, cuddling or daily social contact.screening of donated blood for htlv-1 has been done in the united states since 1988. last updated: 3/16/2011

MalaCards: Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis, also known as tropical spastic paraparesis, is related to tropical spastic paraparesis and dermatitis. An important gene associated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis is KLRK1 (killer cell lectin-like receptor subfamily K, member 1), and among its related pathways are Apoptosis Pathway and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds cycloheximide and pge2 have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are skeleton and integument.

Aliases & Classifications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

htlv-1 associated myelopathy/tropical spastic paraparesis 42
tropical spastic paraparesis 42 60
human t-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis 42
ham/tsp 42


Related Diseases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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17GeneCards, 18GeneDecks
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Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1tropical spastic paraparesis31.7MBP, FASLG, CNTN2, IL2RA, IL2
2dermatitis31.1CX3CR1
3multiple sclerosis31.0HLA-DRB1, HLA-DQB1
4t-cell leukemia30.9JUN, TNFRSF4, FASLG, NFKB1, MYC, CNTN2
5leukemia30.9KLRK1, JUN, MBP, TNFRSF4, FASLG, HLA-DRB1
6htlv-1 associated myelopathy30.7CNTN2, FASLG
7adult t-cell leukemia30.7IL2RA, CNTN2
8neuropathy30.7MBP, NEFL, NEFH
9vasculitis30.5NFKB1
10amyotrophic lateral sclerosis30.5RPS27A, NEFL, NEFH
11systemic lupus erythematosus30.3PDCD1
12acute leukemia30.3IL2
13sarcoma30.3IL2, VDR
14lyme disease30.3MBP
15thyroiditis30.3FASLG, HLA-DRB1
16psoriasis30.3HLA-DRB1, HLA-A, VDR, CX3CR1, IL2RA, IL2
17neurologic diseases10.5
18retrovirus-associated myelopathy10.5
19hypertension10.5
20peripheral neuropathy10.5
21cerebritis10.5
22adult lymphoma10.5
23spinal cord disease10.5
24myelitis10.4
25lateral sclerosis10.4
26strongyloidiasis10.2
27folliculitis10.2
28fibrous histiocytoma10.2
29acute t cell leukemia10.2
30postpartum depression10.2
31hemoglobinuria10.2
32neuroaxonal dystrophy10.2
33central nervous system leukemia10.2
34protein s deficiency10.2
35cerebral lymphoma10.2
36spinal cord sarcoma10.2
37osteoporosis10.2
38central nervous system disease10.2
39cutaneous t cell lymphoma10.2
40histiocytoma10.2
41lupus erythematosus10.2
42nervous system disease10.2
43paraplegia10.2
44syphilis10.2
45t cell deficiency10.2
46acute ackee fruit intoxication10.2
47pseudopseudohypoparathyroidism10.2
48silicosis10.0FASLG
49ankylosing spondylitis10.0HLA-A
50parkinson's disease10.0RPS27A

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:



Diseases related to htlv-1 associated myelopathy/tropical spastic paraparesis

Clinical Features for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Drugs & Therapeutics for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Anatomical Context for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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MalaCards organs/tissues related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

32
T cells

Animal Models for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.5MYC, FASLG, PDCD1
2MP:00107719.3FASLG, MYC, VDR, CX3CR1, JUN
3MP:00053799.1JUN, FASLG, MYC, VDR, IL2
4MP:00053858.4JUN, PDCD1, FASLG, HLA-DQB1, MYC, VDR
5MP:00053708.3JUN, PDCD1, TNFRSF4, FASLG, HLA-DQB1, NFKB1
6MP:00053818.2TNFRSF4, FASLG, HLA-DQB1, NFKB1, MYC, VDR
7MP:00036318.2JUN, HLA-DQB1, NEFL, NEFH, MYC, VDR
8MP:00028737.6JUN, MBP, TNFRSF4, FASLG, HLA-DQB1, NEFL
9MP:00053766.9JUN, MBP, FASLG, HLA-DQB1, NFKB1, MYC
10MP:00053866.5JUN, MBP, HLA-DQB1, NEFH, NFKB1, MYC
11MP:00107686.4FASLG, MBP, PDCD1, JUN, KLRK1, HLA-DQB1
12MP:00053976.2IL2, KLRK1, JUN, PDCD1, MBP, TNFRSF4
13MP:00053876.1FASLG, TNFRSF4, MBP, PDCD1, JUN, KLRK1
14MP:00053845.8FASLG, TNFRSF4, MBP, PDCD1, JUN, KLRK1

Publications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Genetic Variations for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Expression for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis.

Pathways for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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59Tocris Bioscience, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 49PharmGKB, 29KEGG, 55SinoBiological
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Pathways related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0IL2RA, JUN
2
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9.8FASLG, IL2RA, IL2
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.7JUN, FASLG, VDR
49.7IL2RA, MYC, NFKB1
5
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9.7RPS27A, JUN, NFKB1
69.7MYC, NFKB1, JUN
7
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
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9.7JUN, NFKB1, MYC
8
Apoptosis and survival Lymphotoxin-beta receptor signaling
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9.6JUN, NFKB1, IL2
99.6JUN, NFKB1, IL2
109.6IL2, NFKB1, JUN
11
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9.6KLRK1, RPS27A, HLA-A, NFKB1
12
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9.5IL2, IL2RA, FASLG, JUN
13
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9.5RPS27A, NFKB1, IL2RA, IL2
14
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9.5MYC, NFKB1, FASLG, JUN
159.5MYC, NFKB1, FASLG, JUN
16
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9.5JUN, FASLG, NFKB1, MYC
17
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9.4IL2, NFKB1, PDCD1, JUN
18
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9.4IL2, IL2RA, MYC, JUN
19
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9.4JUN, NFKB1, IL2RA, IL2
209.4IL2, MYC, NFKB1, JUN
219.3IL2, NFKB1, TNFRSF4, JUN
22
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9.2FASLG, NFKB1, MYC, IL2RA, IL2
239.2FASLG, NFKB1, MYC, IL2RA, IL2
24
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9.2HLA-DQB1, HLA-DRB1, NFKB1
25
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9.2TNFRSF4, FASLG, HLA-DQB1, HLA-A
26
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9.2IL2, MYC, NFKB1, FASLG, JUN
279.2JUN, HLA-DRB1, IL2RA, IL2
28
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9.2JUN, NFKB1, MYC, IL2RA, IL2
29
Immune response IL-2 activation and signaling pathway
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9.2JUN, NFKB1, MYC, IL2RA, IL2
30
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9.2JUN, TNFRSF4, NFKB1, CX3CR1, IL2RA
31
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9.1JUN, TNFRSF4, NFKB1, MYC, CX3CR1
32
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9.0KLRK1, JUN, FASLG, HLA-A, NFKB1, IL2
33
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9.0NFKB1, HLA-DRB1, HLA-DQB1, RPS27A
349.0HLA-DQB1, HLA-DRB1, NFKB1, VDR
35
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9.0TNFRSF4, FASLG, NFKB1, MYC, CX3CR1, IL2RA
368.9JUN, TNFRSF4, FASLG, HLA-A, IL2RA, IL2
37
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8.9FASLG, HLA-DQB1, HLA-DRB1, HLA-A, IL2RA
38
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8.7PDCD1, HLA-DQB1, HLA-DRB1, CD274
39
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8.7CD274, HLA-DRB1, HLA-DQB1, PDCD1
408.7PDCD1, HLA-DQB1, HLA-DRB1, HLA-A, CNTN2
418.5JUN, HLA-DQB1, HLA-DRB1, HLA-A, NFKB1, MYC
42
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8.5IL2, JUN, FASLG, HLA-DRB1, HLA-A, NFKB1
438.4JUN, HLA-DQB1, HLA-DRB1, MYC, IL2RA, IL2
44
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8.4JUN, HLA-DQB1, HLA-DRB1, NFKB1, IL2RA, IL2
45
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8.3RPS27A, HLA-DQB1, HLA-DRB1, HLA-A, NFKB1, IL2RA
46
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8.2JUN, HLA-DQB1, HLA-DRB1, NFKB1, MYC, IL2RA
47
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8.2JUN, HLA-DQB1, HLA-DRB1, NFKB1, MYC, IL2RA
48
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8.0JUN, FASLG, HLA-DQB1, HLA-DRB1, HLA-A, NFKB1
498.0JUN, HLA-DQB1, HLA-DRB1, HLA-A, NFKB1, MYC
50
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7.0KLRK1, RPS27A, JUN, PDCD1, HLA-DQB1, HLA-DRB1

Compounds for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 2BitterDB
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Compounds related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7FASLG
2pge24410.5IL2
3arsenite44 2411.2VDR, FASLG, RPS27A
4estrogen4410.2CNTN2, VDR
5c-d4t4410.1IL2, IL2RA, FASLG
6propanil4410.0RPS27A, MYC, IL2
7butyrate4410.0RPS27A
8sodium arsenite449.9JUN, FASLG, MYC, IL2RA
9dexamethasone44 49 28 1112.9VDR, MYC, FASLG, JUN
10alpha-amanitin449.9CNTN2, MYC, JUN
11indomethacin44 59 28 1112.8MBP, RPS27A
124-hydroxytamoxifen449.8JUN, FASLG, MYC, VDR
13aspartate449.8RPS27A, FASLG, VDR
14bortezomib44 1110.8MYC, FASLG, JUN, RPS27A
15levamisole44 1110.8IL2, IL2RA, HLA-A
16gold sodium thiomalate449.7HLA-DRB1, IL2RA, IL2
17serine449.7JUN, NEFH, VDR
18thalidomide44 49 59 1112.7FASLG, NFKB1, IL2RA, IL2
19anisomycin44 1110.7JUN, FASLG, MYC, IL2RA
20lactacystin449.7RPS27A, JUN, FASLG, MYC, VDR
21n-(4-hydroxyphenyl)retinamide449.7CNTN2, MYC, JUN, RPS27A
22mg 13244 5910.7RPS27A, JUN, FASLG, MYC, VDR
23tamoxifen44 49 28 1112.6IL2, VDR, FASLG, JUN, RPS27A
24rantes449.6IL2, IL2RA, FASLG, JUN
25herbimycin a44 5910.6RPS27A, JUN, MYC, IL2RA, IL2
265fluorouracil449.5IL2, IL2RA, VDR, HLA-A, FASLG
27calcitriol44 59 11 2412.5JUN, MYC, VDR, IL2RA, IL2
28camptothecin44 59 1111.5RPS27A, JUN, FASLG, MYC, CNTN2
29tacrolimus44 49 1111.5RPS27A, FASLG, MYC, VDR, IL2RA, IL2
30rapamycin449.4RPS27A, JUN, FASLG, MYC, IL2RA, IL2
31actinomycin d449.3RPS27A, JUN, FASLG, MYC, VDR, IL2
32glutamate449.3MBP, NEFL, CNTN2
33genistein44 28 59 2 11 2414.3JUN, FASLG, MYC, VDR, IL2RA, IL2
34retinoid449.3CNTN2, VDR, MYC, JUN, RPS27A
35etoposide44 49 59 1112.3JUN, FASLG, NFKB1, MYC, CNTN2, IL2RA
36glatiramer acetate44 1110.1MBP, HLA-DRB1, IL2
37cytarabine44 49 1110.9MYC, FASLG, MBP, JUN
38n acetylcysteine448.9RPS27A, JUN, MBP, FASLG, MYC, IL2RA
39vegf448.8RPS27A, JUN, FASLG, MYC, CNTN2, CX3CR1
40paraffin448.8RPS27A, MBP, FASLG, NEFH, MYC, IL2RA
41cisplatin44 49 59 1111.6RPS27A, MBP, FASLG, MYC, IL2RA, IL2
42ionomycin448.5JUN, TNFRSF4, FASLG, CNTN2, CD274, IL2RA
43adenylate448.4RPS27A, MBP, FASLG, HLA-A, VDR, IL2RA
44oligonucleotide448.4JUN, FASLG, HLA-DQB1, HLA-DRB1, HLA-A, MYC
45thymidine44 249.2JUN, MBP, FASLG, MYC, VDR, CNTN2
46arginine448.1KLRK1, RPS27A, MBP, HLA-DRB1, HLA-A, VDR
47alanine448.0RPS27A, MBP, FASLG, HLA-DRB1, HLA-A, MYC
48retinoic acid44 248.9KLRK1, RPS27A, JUN, MBP, FASLG, NEFL
49cyclosporin a44 28 599.9IL2RA, RPS27A, JUN, MBP, TNFRSF4, HLA-A
50tyrosine446.5FASLG, MBP, PDCD1, JUN, RPS27A, HLA-DQB1

GO Terms for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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16Gene Ontology
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Cellular components related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurofilamentGO:0058839.5NEFH, NEFL
2integral to lumenal side of endoplasmic reticulum membraneGO:0715569.3HLA-DQB1, HLA-DRB1, HLA-A
3ER to Golgi transport vesicle membraneGO:0125079.3HLA-A, HLA-DRB1, HLA-DQB1
4endocytic vesicle membraneGO:0306669.2RPS27A, HLA-DQB1, HLA-DRB1
5external side of plasma membraneGO:0098978.5IL2RA, CD274, HLA-DRB1, FASLG, TNFRSF4, PDCD1
6plasma membraneGO:0058866.6PDCD1, MBP, HLA-DQB1, HLA-DRB1, HLA-A, CNTN2

Biological processes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:04601310.3IL2, IL2RA
2positive regulation of immunoglobulin secretionGO:05102410.1IL2, TNFRSF4
3negative regulation of inflammatory responseGO:05072810.0IL2, IL2RA, NFKB1
4toll-like receptor 10 signaling pathwayGO:03416610.0RPS27A, JUN, NFKB1
5toll-like receptor 5 signaling pathwayGO:03414610.0RPS27A, JUN, NFKB1
6toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.9RPS27A, JUN, NFKB1
7toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.9RPS27A, JUN, NFKB1
8toll-like receptor 9 signaling pathwayGO:0341629.9NFKB1, JUN, RPS27A
9toll-like receptor 2 signaling pathwayGO:0341349.9RPS27A, JUN, NFKB1
10TRIF-dependent toll-like receptor signaling pathwayGO:0356669.9NFKB1, JUN, RPS27A
11immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.8HLA-DQB1, HLA-DRB1
12MyD88-independent toll-like receptor signaling pathwayGO:0027569.8RPS27A, JUN, NFKB1
13toll-like receptor 3 signaling pathwayGO:0341389.8RPS27A, JUN, NFKB1
14humoral immune response mediated by circulating immunoglobulinGO:0024559.8HLA-DRB1, HLA-DQB1
15response to growth factor stimulusGO:0708489.7MYC, FASLG
16MyD88-dependent toll-like receptor signaling pathwayGO:0027559.7RPS27A, JUN, NFKB1
17toll-like receptor 4 signaling pathwayGO:0341429.7NFKB1, JUN, RPS27A
18interferon-gamma-mediated signaling pathwayGO:0603339.6HLA-DQB1, HLA-DRB1, HLA-A
19negative regulation of apoptotic processGO:0430669.5RPS27A, NFKB1, MYC, CX3CR1, IL2
20negative regulation of T cell proliferationGO:0421309.5HLA-DRB1, CD274, IL2RA
21T cell receptor signaling pathwayGO:0508529.4NFKB1, HLA-DRB1, HLA-DQB1, RPS27A
22cytokine-mediated signaling pathwayGO:0192219.4RPS27A, HLA-DQB1, HLA-DRB1, HLA-A
23positive regulation of transcription from RNA polymerase II promoterGO:0459449.3RPS27A, JUN, NFKB1, MYC, VDR, IL2
24negative regulation of transcription from RNA polymerase II promoterGO:0001229.2RPS27A, FASLG, NFKB1, MYC, VDR
25T cell costimulationGO:0312959.0PDCD1, HLA-DQB1, HLA-DRB1, CD274
26immune responseGO:0069557.1IL2, MBP, TNFRSF4, FASLG, HLA-DQB1, HLA-DRB1

Molecular functions related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.5HLA-DRB1, HLA-DQB1

Products for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Sources for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet