MCID: HTL001
MIFTS: 22

Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis malady

Rare diseases category
Download this MalaCard

Summaries for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section


Fully expand this MalaCard
NIH Rare Diseases:42 Htlv-1 associated myelopathy/tropical spastic paraparesis (ham/tsp) is a chronic, progressive disease of the nervous system that affects less than 2 percent of people with htlv-1 infection. signs and symptoms vary but may include progressive weakness, stiff muscles, muscle spasms, backache, a 'weak' bladder, and constipation. the htlv-1 virus can be transmitted from mother to child via breastfeeding or childbirth, from person to person through sexual contact and through blood contact, either by transfusion or by reuse of injection equipment. htlv infection is not passed from person to person by coughing, sneezing, kissing, cuddling or daily social contact.screening of donated blood for htlv-1 has been done in the united states since 1988. last updated: 3/16/2011

MalaCards based summary: Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis, also known as tropical spastic paraparesis, is related to htlv-1 associated myelopathy and tropical spastic paraparesis. An important gene associated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis is CX3CR1 (chemokine (C-X3-C motif) receptor 1). Affiliated tissues include t cells, spinal cord and b cells.

Aliases & Classifications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section

Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis, Aliases & Descriptions:

Name: Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis 42
Tropical Spastic Paraparesis 42 62
Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/tropical Spastic Paraparesis 42
 
Htlv-1-Associated Myelopathy-Tropical Spastic Paraparesis 62
Ham/tsp 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:



Diseases related to htlv-1 associated myelopathy/tropical spastic paraparesis

Symptoms for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section

Drugs & Therapeutics for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section

Drug clinical trials:

Search ClinicalTrials for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Search NIH Clinical Center for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Genetic Tests for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section

Anatomical Context for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section

MalaCards organs/tissues related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

32
T cells, Spinal cord, B cells

Animal Models for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis or affiliated genes

About this section

Publications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section

Articles related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

(show all 23)
idTitleAuthorsYear
1
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. (24472094)
2014
2
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (25227931)
2014
3
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. (23278610)
2013
4
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. (23932323)
2013
5
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. (22720101)
2012
6
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
7
HTLV-1 associated myelopathy/tropical spastic paraparesis: how far have we come? (22519224)
2011
8
Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina. (20572090)
2010
9
Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population. (20851016)
2010
10
Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). (20169122)
2010
11
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (19228429)
2009
12
Is human T cell lymphotropic type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) syndrome a neglected disease? (19936247)
2009
13
High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. (19578703)
2009
14
Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease. (17884099)
2008
15
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. (17717136)
2007
16
Nocturnal hypertension and autonomic dysfunction due to human T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (16503269)
2006
17
Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. (17034574)
2006
18
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. (15961107)
2005
19
Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. (15722539)
2005
20
HTLV-1 associated myelopathy/tropical spastic paraparesis in Egypt. (8912212)
1996
21
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis. (8555734)
1995
22
Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil. (8372632)
1993
23
HTLV-1 associated myelopathy/tropical spastic paraparesis with adult T-cell leukemia. (1736016)
1992

Variations for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section

Expression for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section
Expression patterns in normal tissues for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis.

Pathways for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section

Compounds for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section

GO Terms for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section

Products for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet