MCID: HTL001
MIFTS: 31

Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Aliases & Descriptions for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

Name: Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis 50
Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/tropical Spastic Paraparesis 50
Tropical Spastic Paraparesis 69
Ham/tsp 50

Classifications:



Summaries for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

NIH Rare Diseases : 50 htlv-1 associated myelopathy/tropical spastic paraparesis (ham/tsp) is a chronic, progressive disease of the nervous system that affects less than 2 percent of people with htlv-1 infection. signs and symptoms vary but may include progressive weakness, stiff muscles, muscle spasms, backache, a 'weak' bladder, and constipation. the htlv-1 virus can be transmitted from mother to child via breastfeeding or childbirth, from person to person through sexual contact and through blood contact, either by transfusion or by reuse of injection equipment. htlv infection is not passed from person to person by coughing, sneezing, kissing, cuddling or daily social contact.screening of donated blood for htlv-1 has been done in the united states since 1988. last updated: 3/16/2011

MalaCards based summary : Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis, also known as human t-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis, is related to myelopathy, htlv-1-associated and tropical spastic paraparesis. An important gene associated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis is IFNL3 (Interferon Lambda 3), and among its related pathways/superpathways are Innate Immune System and Epstein-Barr virus infection. The drugs Cyclosporine and Zidovudine have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and spinal cord, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Related Diseases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
id Related Disease Score Top Affiliating Genes
1 myelopathy, htlv-1-associated 12.0
2 tropical spastic paraparesis 11.8
3 human t-cell leukemia virus type 1 11.4
4 retrovirus-associated myelopathy 11.4
5 spastic paraparesis 10.8
6 spasticity 10.8
7 dermatitis 10.4
8 infective dermatitis associated with htlv-1 10.4
9 leukemia 10.3
10 t-cell leukemia 10.3
11 adult t-cell leukemia 10.1
12 myopathy 10.1
13 neuropathy 10.1
14 autonomic dysfunction 10.1
15 inflammatory bowel disease 3 9.8 HLA-A KLRK1
16 thyroid cancer, nonmedullary, 4 9.8 CD274 MYC
17 hunter rudd hoffmann syndrome 9.2 CD274 HLA-A IFNL3 KLRK1 MYC

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:



Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Symptoms & Phenotypes for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

GenomeRNAi Phenotypes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.7 MYC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.7 CD274 MYC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.7 MYC
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.7 CD274
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.7 CD274
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.7 CD274
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.7 CD274
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.7 CD274
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.7 MYC
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.7 MYC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.44 HLA-A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.44 HLA-A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.44 HLA-A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.44 HLA-A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.44 MYC HLA-A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.44 HLA-A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.44 MYC
18 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.44 MYC
19 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.44 HLA-A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.44 HLA-A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.44 MYC
22 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.44 HLA-A

Drugs & Therapeutics for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Drugs for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclosporine Approved, Investigational, Vet_approved Phase 2, Phase 3 79217-60-0, 59865-13-3 5284373 6435893
2
Zidovudine Approved Phase 2, Phase 3,Early Phase 1 30516-87-1 35370
3
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
4
Valproic Acid Approved, Investigational Phase 3 99-66-1 3121
5
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
6
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
7 GABA Agents Phase 3
8 Neurotransmitter Agents Phase 3
9 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Early Phase 1
10 Dermatologic Agents Phase 2, Phase 3
11 Tranquilizing Agents Phase 3
12 Vasodilator Agents Phase 3
13 Phosphodiesterase Inhibitors Phase 3
14 Platelet Aggregation Inhibitors Phase 3
15 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
16 Anti-Infective Agents Phase 2, Phase 3, Early Phase 1
17 Immunosuppressive Agents Phase 2, Phase 3
18 Anticonvulsants Phase 3
19 Protective Agents Phase 3
20 Antifungal Agents Phase 2, Phase 3
21 Psychotropic Drugs Phase 3
22 Antimanic Agents Phase 3
23 Radiation-Protective Agents Phase 3
24 Antimetabolites Phase 2, Phase 3,Early Phase 1
25 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
26 Reverse Transcriptase Inhibitors Phase 2, Phase 3,Early Phase 1
27 Antirheumatic Agents Phase 2, Phase 3
28 Calcineurin Inhibitors Phase 2, Phase 3
29 Antiviral Agents Phase 2, Phase 3,Early Phase 1
30 Antioxidants Phase 3
31 Central Nervous System Depressants Phase 3
32
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
33
Infliximab Approved Phase 2 170277-31-3
34 interferons Phase 2
35 Adjuvants, Immunologic Phase 2
36 Interferon-beta Phase 2
37 Gastrointestinal Agents Phase 2
38 Immunoglobulins Phase 1
39 Antibodies, Monoclonal Phase 1
40 Antibodies Phase 1
41 HIV Integrase Inhibitors Early Phase 1
42 Integrase Inhibitors Early Phase 1
43 Raltegravir Potassium Early Phase 1

Interventional clinical trials:

(show all 20)
id Name Status NCT ID Phase
1 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3
2 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3
3 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3
4 Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) Completed NCT00681980 Phase 3
5 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3
6 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2
7 The HAM Infliximab Study Terminated NCT00823641 Phase 2
8 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Recruiting NCT00076843 Phase 1
9 Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM) Recruiting NCT02961712 Phase 1
10 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Unknown status NCT01754311
11 Evaluation of the MP Diagnostics HTLV Blot 2.4 Unknown status NCT01467024
12 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
13 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
14 Assessment of Patients With Multiple Sclerosis (MS) Completed NCT00001156
15 Raltegravir for HAM/TSP Recruiting NCT01867320 Early Phase 1
16 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
17 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Enrolling by invitation NCT01651819
18 Dual Algorithm Post Market Clinical Study Enrolling by invitation NCT03146013
19 Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection Not yet recruiting NCT02655471 Early Phase 1
20 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181

Search NIH Clinical Center for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Genetic Tests for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Anatomical Context for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

MalaCards organs/tissues related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

39
T Cells, B Cells, Spinal Cord

Publications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Articles related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

(show all 26)
id Title Authors Year
1
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
2
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
3
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
4
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. ( 24472094 )
2014
5
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25227931 )
2014
6
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. ( 23278610 )
2013
7
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. ( 23932323 )
2013
8
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 22720101 )
2012
9
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 21510232 )
2011
10
HTLV-1 associated myelopathy/tropical spastic paraparesis: how far have we come? ( 22519224 )
2011
11
Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population. ( 20851016 )
2010
12
Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina. ( 20572090 )
2010
13
Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 20169122 )
2010
14
Is human T cell lymphotropic type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) syndrome a neglected disease? ( 19936247 )
2009
15
High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. ( 19578703 )
2009
16
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 19228429 )
2009
17
Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease. ( 17884099 )
2008
18
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. ( 17717136 )
2007
19
Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. ( 17034574 )
2006
20
Nocturnal hypertension and autonomic dysfunction due to human T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 16503269 )
2006
21
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 15961107 )
2005
22
Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. ( 15722539 )
2005
23
HTLV-1 associated myelopathy/tropical spastic paraparesis in Egypt. ( 8912212 )
1996
24
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 8555734 )
1995
25
Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil. ( 8372632 )
1993
26
HTLV-1 associated myelopathy/tropical spastic paraparesis with adult T-cell leukemia. ( 1736016 )
1992

Variations for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Expression for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis.

Pathways for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Pathways related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 CD274 HLA-A IFNL3 KLRK1 MYC
2 11.63 HLA-A MYC
3
Show member pathways
11.49 IFNL3 MYC
4 11.32 CD274 HLA-A
5 11.09 HLA-A KLRK1

GO Terms for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Cellular components related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 CD274 HLA-A KLRK1

Biological processes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 8.96 HLA-A KLRK1
2 T cell costimulation GO:0031295 8.62 CD274 KLRK1

Sources for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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