MCID: HTL001
MIFTS: 32

Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

MalaCards integrated aliases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

Name: Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis 49
Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/tropical Spastic Paraparesis 49
Tropical Spastic Paraparesis 69
Ham/tsp 49

Classifications:



Summaries for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

NIH Rare Diseases : 49 HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive disease of the nervous system that affects less than 2% of people with HTLV-1 infection. Signs and symptoms vary but may include slowly progressive weakness and spasticity of one or both legs, exaggerated reflexes, muscle contractions in the ankle, and lower back pain. Other features may include urinary incontinence and minor sensory changes, especially burning or prickling sensations and loss of vibration sense. Why some people with HTLV-1 infection develop HAM/TSTP is not well understood. Treatment generally aims to control the specific symptoms, as there is no standard treatment available.Interferon alpha may be beneficial over short periods, and some aspects of the disease may be improved with interferon beta. Other medication may include immune globulin, oral corticoids and muscular relaxes such as baclofen or tizanidine. Last updated: 7/12/2017

MalaCards based summary : Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis, also known as human t-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis, is related to myelopathy, htlv-1-associated and tropical spastic paraparesis. An important gene associated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis is HLA-A (Major Histocompatibility Complex, Class I, A), and among its related pathways/superpathways are Jak-STAT signaling pathway (KEGG) and Epstein-Barr virus infection. The drugs Zidovudine and Lamivudine have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and b cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 myelopathy, htlv-1-associated 11.9
2 tropical spastic paraparesis 11.9
3 human t-cell leukemia virus type 1 11.5
4 retrovirus-associated myelopathy 11.5
5 spastic paraparesis 10.9
6 spasticity 10.9
7 leukemia 10.5
8 t-cell leukemia 10.5
9 dermatitis 10.5
10 infective dermatitis associated with htlv-1 10.5
11 adult t-cell leukemia 10.4
12 blood group, i system 10.2
13 multiple sclerosis 10.2
14 lymphoma 10.2
15 myopathy 10.2
16 neuropathy 10.2
17 autonomic dysfunction 10.2
18 kaposi sarcoma 9.8 HLA-A MYC
19 alveolar echinococcosis 9.7 HLA-A KLRK1
20 celiac disease 1 9.6 HLA-A KLRK1
21 nasopharyngeal carcinoma 9.6 HLA-A MYC

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:



Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Symptoms & Phenotypes for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

GenomeRNAi Phenotypes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

25 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.44 HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.44 HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.44 HLA-A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.44 HLA-A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.44 HLA-A MYC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.44 HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.44 MYC
8 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.44 MYC
9 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.44 HLA-A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.44 HLA-A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.44 MYC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.44 HLA-A
13 Increased cell size GR00098-A-4 8.96 MYC NEFH

Drugs & Therapeutics for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Drugs for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
2
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
3
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
4
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
5 Reverse Transcriptase Inhibitors Phase 2, Phase 3
6 Cyclosporins Phase 2, Phase 3
7 Vasodilator Agents Phase 3
8 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
9 Dermatologic Agents Phase 2, Phase 3
10 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
11 Phosphodiesterase Inhibitors Phase 3
12 Anti-Infective Agents Phase 2, Phase 3, Early Phase 1
13 Antifungal Agents Phase 2, Phase 3
14 Platelet Aggregation Inhibitors Phase 3
15 Immunosuppressive Agents Phase 2, Phase 3
16 Antimetabolites Phase 2, Phase 3
17 Protective Agents Phase 3
18 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
19 Radiation-Protective Agents Phase 3
20 Antioxidants Phase 3
21 Antirheumatic Agents Phase 2, Phase 3
22 Calcineurin Inhibitors Phase 2, Phase 3
23 Antiviral Agents Phase 2, Phase 3,Early Phase 1
24
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
25
Infliximab Approved Phase 2 170277-31-3
26 interferons Phase 2
27 Adjuvants, Immunologic Phase 2
28 Interferon-beta Phase 2
29 Gastrointestinal Agents Phase 2
30 Antibodies, Monoclonal Phase 1
31 Immunoglobulins Phase 1
32 Antibodies Phase 1
33
Valproic Acid Approved, Investigational 99-66-1 3121
34 Raltegravir Potassium Early Phase 1
35 HIV Integrase Inhibitors Early Phase 1
36 Integrase Inhibitors Early Phase 1
37 Central Nervous System Depressants
38 GABA Agents
39 Neurotransmitter Agents
40 Tranquilizing Agents
41 Anticonvulsants
42 Antimanic Agents
43 Psychotropic Drugs

Interventional clinical trials:

(show all 14)

# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
2 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
3 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
4 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine
5 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
6 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
7 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
8 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Unknown status NCT01651819
9 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Unknown status NCT01754311
10 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
11 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
12 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
13 Raltegravir for HAM/TSP Active, not recruiting NCT01867320 Early Phase 1 Raltegravir
14 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181 Valproic Acid

Search NIH Clinical Center for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Genetic Tests for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Anatomical Context for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

MalaCards organs/tissues related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

38
T Cells, Brain, B Cells, Spinal Cord

Publications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Articles related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

(show all 28)
# Title Authors Year
1
Role of Integrin Signaling Activation on the Development of Human T-Cell Leukemia VIrus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
2
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
3
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2017
4
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
5
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
6
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25227931 )
2014
7
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. ( 24472094 )
2014
8
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. ( 23278610 )
2013
9
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. ( 23932323 )
2013
10
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 22720101 )
2012
11
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 21510232 )
2011
12
HTLV-1 associated myelopathy/tropical spastic paraparesis: how far have we come? ( 22519224 )
2011
13
Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population. ( 20851016 )
2010
14
Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina. ( 20572090 )
2010
15
Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 20169122 )
2010
16
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 19228429 )
2009
17
High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. ( 19578703 )
2009
18
Is human T cell lymphotropic type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) syndrome a neglected disease? ( 19936247 )
2009
19
Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease. ( 17884099 )
2008
20
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. ( 17717136 )
2007
21
Nocturnal hypertension and autonomic dysfunction due to human T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 16503269 )
2006
22
Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. ( 17034574 )
2006
23
Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. ( 15722539 )
2005
24
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 15961107 )
2005
25
HTLV-1 associated myelopathy/tropical spastic paraparesis in Egypt. ( 8912212 )
1996
26
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 8555734 )
1995
27
Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil. ( 8372632 )
1993
28
HTLV-1 associated myelopathy/tropical spastic paraparesis with adult T-cell leukemia. ( 1736016 )
1992

Variations for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Expression for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis.

Pathways for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

GO Terms for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Biological processes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 8.62 HLA-A KLRK1

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