MCID: HTL001
MIFTS: 45

Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Aliases & Descriptions for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

Name: Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis 46
Tropical Spastic Paraparesis 46 66
 
Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/tropical Spastic Paraparesis 46
Ham/tsp 46

Classifications:



Summaries for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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NIH Rare Diseases:46 Htlv-1 associated myelopathy/tropical spastic paraparesis (ham/tsp) is a chronic, progressive disease of the nervous system that affects less than 2 percent of people with htlv-1 infection. signs and symptoms vary but may include progressive weakness, stiff muscles, muscle spasms, backache, a 'weak' bladder, and constipation. the htlv-1 virus can be transmitted from mother to child via breastfeeding or childbirth, from person to person through sexual contact and through blood contact, either by transfusion or by reuse of injection equipment. htlv infection is not passed from person to person by coughing, sneezing, kissing, cuddling or daily social contact.screening of donated blood for htlv-1 has been done in the united states since 1988. last updated: 3/16/2011

MalaCards based summary: Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis, also known as tropical spastic paraparesis, is related to tropical spastic paraparesis and spastic paraparesis, and has symptoms including hemiparesis, hemiplegia and paresis. An important gene associated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis is HLA-A (Major Histocompatibility Complex, Class I, A), and among its related pathways are Phagosome and TSLP Signaling Pathway. Affiliated tissues include t cells, brain and b cells, and related mouse phenotypes are liver/biliary system and integument.

Related Diseases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1tropical spastic paraparesis10.9
2spastic paraparesis10.9
3spasticity10.9
4branch retinal artery occlusion10.8HLA-A, HLA-B
5malignant cardiac germ cell tumor10.7HLA-A, HLA-DQB1
6fruit allergy10.7HLA-DQB1, HLA-DRB1
7wolffian duct adenocarcinoma10.7HLA-DQB1, HLA-DRB1
8gonococcal iridocyclitis10.7HLA-A, HLA-B
9progressive locomotor ataxia10.7HLA-A, HLA-B, HLA-DRB1
10quinquaud's decalvans folliculitis10.7HLA-DQB1, HLA-DRB1
11hypercementosis10.7HLA-A, HLA-B, HLA-DRB1
12potato nose10.7HLA-A, HLA-B, HLA-DRB1
13arachnoiditis10.7HLA-A, HLA-B, HLA-DRB1
14ovarian papillary cystadenoma10.7HLA-B, HLA-DQB1, HLA-DRB1
15x-linked congenital generalized hypertrichosis10.6HLA-B, HLA-DQB1, HLA-DRB1
16common variable immunodeficiency10.6HLA-B, HLA-DRB1
17allergic hypersensitivity disease10.6HLA-B, HLA-DQB1, HLA-DRB1
18parsonage turner syndrome10.6HLA-DQB1, HLA-DRB1
19mitochondrial encephalomyopathy10.5HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
20human t-cell leukemia virus type 110.5
21foster-kennedy syndrome10.5HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
22cirrhotic cardiomyopathy10.5HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
23conjunctival pigmentation10.5HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
24dermatitis10.5
25infective dermatitis associated with htlv-110.5
26breast carcinoma in situ10.5HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
27pediatric systemic lupus erythematosus10.5HLA-DQB1, HLA-DRB1
28laryngeal cancer, childhood10.5IL2RA, KLRK1
29myopathy-growth delay-intellectual disability-hypospadias syndrome10.4HLA-DQB1, HLA-DRB1
30krieble bixler syndrome10.4HLA-DQB1, HLA-DRB1
31hodgkin's lymphoma, mixed cellularity10.4HLA-B, HLA-DRB1, IL2
32leukemia10.4
33t-cell leukemia10.4
34vitreoretinochoroidopathy dominant10.4HLA-B, HLA-DQB1, HLA-DRB1, IL2
35male urethral cancer10.4HLA-A, IL2, IL2RA
36emphysema, congenital lobar10.4HLA-A, HLA-B, HLA-DRB1, IL2
37respiratory system disease10.3HLA-DRB1, IL2, IL2RA
38adult t-cell leukemia10.3
39myopathy10.3
40neuropathy10.3
41autonomic dysfunction10.3
42skin sarcoidosis10.2HLA-A, HLA-DRB1, IL2, IL2RA
43mastocytosis cutaneous with short stature conductive hearing loss and microtia10.1HLA-DRB1, IFNG, VDR
44lymphocytic colitis10.1HLA-DQB1, HLA-DRB1, IFNG
45orbit alveolar rhabdomyosarcoma10.1HLA-DQB1, HLA-DRB1, IFNG
46gastric dilatation10.0HLA-A, HLA-B, IFNG
47bartter disease10.0HLA-A, HLA-DRB1, IFNG
48orbital periostitis10.0HLA-A, HLA-B, IFNG
49eye accommodation disease10.0IFNG, IL2RA
50anthracosilicosis10.0HLA-DRB1, IFNG, IL2

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:



Diseases related to htlv-1 associated myelopathy/tropical spastic paraparesis

Symptoms for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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UMLS symptoms related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:


hemiparesis, hemiplegia, paresis, paraparesis, todd paralysis, quadriparesis, monoparesis, paresis anal sphincter

Drugs & Therapeutics for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Drugs for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Valproic AcidPhase 331899-66-13121
Synonyms:
(N-C3H7)2CHCOOH
(S)-2-propyl-4-pentanoate
(S)-2-propyl-4-pentanoic acid
2 PP (base)
2-N-Propyl-N-valeric acid
2-Propyl-Pentanoate
2-Propyl-Pentanoic acid
2-Propylpentanoate
2-Propylpentanoic Acid
2-Propylpentanoic acid
2-Propylvaleric Acid
2-Propylvaleric acid
2-n-Propyl-n-valeric acid
2-n-propyl-n-valeric acid
2-propyl-pentanoic acid
2-propylvaleric acid
4-Heptanecarboxylic acid
4-heptanecarboxylic acid
76584-70-8 (hydrochloride salt (2:1))
99-66-1
AC1L1F7T
AC1Q2ULA
AI3-10500
APO-divalproex
Abbott 44090
Acide valproique
Acide valproique [INN-French]
Acide valproique [inn-french]
Acido valproico
Acido valproico [INN-Spanish]
Acido valproico [inn-spanish]
Acidum valproicum
Acidum valproicum [INN-Latin]
Acidum valproicum [inn-latin]
Alti-Valproic
Alti-valproic
Apo-valproic
Apo-valproic syrup
Avugane
BIDD:GT0858
BRN 1750447
Baceca
C07185
CHEBI:39867
CHEMBL109
CID3121
CPD000499581
Convulex
Convulsofin
D00399
DB00313
DOM-divalproex
DOM-valproic
DOM-valproic acid E.C.
DPA
Delepsine
Depacon
Depakene
Depakene (TN)
Depakin
Depakin chrono
Depakine
Depakine chrono
Depakote
Depakote (TM)
Deproic
Di-N-propylacetic acid
Di-N-propylessigsaure
Di-N-propylessigsaure [german]
Di-n-propylacetic acid
Di-n-propylessigsaeure
Di-n-propylessigsaure
Di-n-propylessigsaure [German]
Di-n-propylessigsäure
Dipropyl Acetate
Dipropylacetate
Dipropylacetic acid
DivK1c_000273
Divalproex
Dom-Valproic
Dom-valproate
Dom-valproic acid
Dom-valproic acid syrup
EINECS 202-777-3
Epiject I.V.
Epilex
Epilim
Epival
Epival er
Ergenyl
G2M-777
Gen-divalproex
HMS2089J06
HSDB 3582
I04-0211
InChI=1/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
KBio1_000273
KBio2_001001
KBio2_002277
KBio2_003569
KBio2_004845
 
KBio2_006137
KBio2_007413
KBio3_002626
KBio3_002757
KBioGR_000871
KBioGR_002277
KBioSS_001001
KBioSS_002278
Kyselina 2-propylvalerova
Kyselina 2-propylvalerova [Czech]
LS-161170
LS-2068
MLS001076682
MLS001335927
MLS001335928
MLS002415770
Med Valproic
Med valproic
MolPort-001-791-895
Mylproin
Myproate
Myproic Acid
Myproic acid
N-DPA
N-Dipropylacetic acid
NCGC00091149-01
NCGC00091149-02
NCGC00091149-03
NCGC00091149-04
NINDS_000273
NSC 93819
NSC93819
Novo-Valproic
Novo-Valproic - ECC
Novo-divalproex
Novo-valproic
Novo-valproic soft gel cap
Nu-Valproic
Nu-valproic
P0823
P6273_SIGMA
PEAC
PHL-valproate
PHL-valproic acid
PHL-valproic acid E.C.
PMS-Divalproex
PMS-Valproic Acid
PMS-valproate
PMS-valproic acid
PMS-valproic acid E.C.
Penta-Valproic
Penta-valproic
Propylvaleric acid
Ratio-Valproic - ECC
S(-)-4-En-valproate
S(-)-4-En-valproic acid
S-2-N-Propyl-4-pentenoate
S-2-N-Propyl-4-pentenoic acid
SAM002564230
SBB065764
SMR000499581
SPBio_000912
Sandoz valproic
Savicol
Semisodium Valproate
Sodium hydrogen divalproate
Spectrum2_000946
Spectrum3_001733
Spectrum4_000376
Spectrum_000521
Sprinkle
Stavzor
UNII-614OI1Z5WI
VALPROIC ACID
VPA
Valcote
Valparin
Valproate
Valproate semisodique [French]
Valproate semisodium
Valproato semisodico [Spanish]
Valproatum seminatricum [Latin]
Valproic Acid, Sodium Salt (2:1)
Valproic acid
Valproic acid (USP)
Valproic acid USP
Valproic acid USP24
Valproic acid [USAN:INN:BAN]
Valproic acid [usan:ban:inn]
Valproinsaeure
Valproinsäure
Vupral
WLN: QVY3 & 3
acide valproïque
acidum valproicum
di-n-propylacetic acid
n-DPA
n-Dipropylacetic acid
nchembio.79-comp4
nchembio815-comp21
valproate
valproic acid
ácido valproico
2
MiconazolePhase 2, Phase 3357322916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
3
PentoxifyllinePhase 3936493-05-64740
Synonyms:
1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion
1-(5-Oxohexyl)-3,7-dimethylxanthine
1-(5-Oxohexyl)theobromine
2a3c
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl) xantine
3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)xanthine
3,7-Dimethyl-1-(5-oxohexyl)xantine
3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
5-26-14-00081 (Beilstein Handbook Reference)
6493-05-6
AB00052363
AC1L1IUN
AKOS000541484
Agapurin
Agapurin Retard
Azupentat
BAS 00897429
BB_SC-2111
BIDD:GT0174
BL 191
BL-191
BL191
BPBio1_000167
BRD-K57569181-001-05-1
BRN 0558929
BSPBio_000151
BSPBio_003439
C07424
C13H18N4O3
CAS-1677687
CCRIS 6832
CHEMBL628
CID4740
CPD000035998
D00501
D010431
DB00806
Dimethyloxohexylxanthine
DivK1c_000729
Durapental
EHT 0201
EHT-0201
EHT-201
EHT0201
EINECS 229-374-5
EU-0100936
HMS1568H13
HMS1922E16
HMS2051N06
HMS2090H13
HMS2093G21
HMS502E11
Hemovas
I06-1592
IDI1_000729
IN1161
Ikomio
KBio1_000729
KBio2_001924
KBio2_004492
KBio2_007060
KBio3_002942
KBioGR_000893
KBioSS_001924
LS-149385
 
Lopac-P-1784
Lopac0_000936
MLS000079026
MLS000758298
MLS001201764
MolPort-001-823-263
NCGC00015801-01
NCGC00015801-02
NCGC00015801-04
NCGC00015801-10
NCGC00067069-02
NCGC00067069-03
NCGC00067069-04
NCGC00067069-05
NCGC00178062-01
NCGC00178062-02
NINDS_000729
NSC 637086
NSC637086
Oxpentifylline
P 1784
PDSP1_001015
PDSP2_000999
PENTOXYPHYLINE
PNX
Pentoxifilina
Pentoxifilina [INN-Spanish]
Pentoxifyllin
Pentoxifylline
Pentoxifylline (JAN/USP/INN)
Pentoxifylline [USAN:INN:JAN]
Pentoxifyllinum
Pentoxifyllinum [INN-Latin]
Pentoxil
Pentoxil (TN)
Pentoxiphyllin
Pentoxiphylline
Pentoxiphyllium
Pentoxyfylline
Pentoxyphyllin
Pentoxyphylline
Prestwick0_000196
Prestwick1_000196
Prestwick2_000196
Prestwick3_000196
Prestwick_608
Px
Ralofect
Rentylin
SAM001247011
SMR000035998
SPBio_001221
SPBio_002072
SPECTRUM1503611
SR-01000075641-4
STK177321
Spectrum2_001181
Spectrum3_001820
Spectrum4_000227
Spectrum5_001161
Spectrum_001444
Torental
Trental
Trental (TN)
UNII-SD6QCT3TSU
Vasofirin
Vazofirin
ZINC01530776
cis-9-Octadecenoyl coenzyme A
pentoxifylline
4
ZidovudinePhase 2, Phase 3, Phase 049530516-87-135370
Synonyms:
-Azido-3&prime
-deoxythymidine
1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine
3&prime
3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
3'-Azido-3'-deoxythymidine & Concanavalin A
3'-Azido-3'-deoxythymidine & Erythropoietin
3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19
3'-Azido-3'-deoxythymidine & Interleukin-1
3'-Azido-3'-deoxythymidine & Interleukin-2
3'-Azido-3'-deoxythymidine & Interleukin-6
3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6
3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon
3'-Azido-3'-deoxythymidine & Sho-Saiko-To
3'-Azido-3'-deoxythymidine (AIDS)
3'-Azido-3'deoxythymidine & Interferon .alpha.
3'-Azidothymidine
3'-Deoxy-3'-azidothymidine
3'-azido-3'-deoxythymidine, AZT
3-Azido-3-deoxythymidine
30516-87-1
399024-19-2
A2169_SIGMA
AC1L1TKL
AC1Q2OEK
AZT
AZT & CD4(178)-PE 40
AZT & Colony-stimulating factor 2
AZT & Concanavalin A (ConA)
AZT & EPO
AZT & GM-CSF
AZT & HPA
AZT & IFN.alpha.
AZT & IL-1
AZT & IL-2
AZT & IL-6
AZT & Interferon-.alpha.-2
AZT & Li & EPO
AZT & Li & GM-CSF
AZT & Li & IL-1
AZT & Li & IL-6
AZT & Lymphoblastoid Interferon
AZT & NP (from PHCA or HSA)
AZT & PM-19
AZT & SST
AZT & rIFN.alpha.2
AZT & rsCD4 & rIFN.alpha.A
AZT & rsT4
AZT & sCD4
AZT & srCD4
AZT (Antiviral)
AZT Antiviral
AZT TRANSPLACENTAL CARCINOGENESIS STUDY
AZT+PRO 140
AZT, Antiviral
Antiviral AZT
Apo-Zidovudine
Azidothymidine
Aztec
BB_NC-1012
BPBio1_000403
BRD-K72903603-001-04-6
BSPBio_000365
BSPBio_003153
BW A509U
BW-A 509U
BW-A-509U
BW-A509U
BWA 509U
BWA-509U
BWA509U
C07210
CCRIS 105
CHEBI:10110
CHEBI:127307
CHEMBL129
CID35370
 
CPD000058351
Compound S
Cpd S
D00413
D015215
DB00495
DRG-0004
DS-4152 & AZT
DivK1c_000524
HMS1921J20
HMS2090G11
HMS2092D06
HMS501K06
HSDB 6515
IDI1_000524
Interferon AD + 3'-azido-3'-deoxythymidine
Intron A & AZT
K7 [P Ti2 W10 O40]
KBio1_000524
KBio2_001828
KBio2_004396
KBio2_006964
KBio3_002653
KBioGR_000703
KBioSS_001828
LS-1159
Liposomal AZT-SN-1
Liposomal AZT-SN-3
MLS000028548
MLS001055351
MLS001076358
MLS002153202
MLS002222249
Met-SDF-1.beta. & AZT
Met-SDF-1.beta. & Zidovudine
MolPort-002-507-286
NCGC00023945-03
NCGC00023945-04
NCGC00023945-05
NCGC00023945-08
NCGC00178237-01
NCGC00178237-02
NINDS_000524
NSC 602670
Novo-Azt
PC-SOD+AZT
Prestwick3_000333
Propolis+AZT
Racemic Liposomal AZT
Retrovir
Retrovir (TN)
Retrovir(TM)
SAM002548971
SMR000058351
SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SPBio_000834
SPECTRUM1502109
STK801891
Spectrum2_000927
Spectrum3_001507
Spectrum4_000332
Spectrum5_001101
Spectrum_001348
UNII-4B9XT59T7S
ZDV
ZIDOVUDINE [AZT]
ZINC03779042
ZVD
Zidovudin
Zidovudina
Zidovudina [Spanish]
Zidovudine (JAN/USP/INN)
Zidovudine EP III
Zidovudine [USAN:INN:BAN:JAN]
Zidovudine+PRO 140
Zidovudinum
Zidovudinum [Latin]
antiviral
azidodeoxythymidine
rIFN-beta seron & AZT
racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
zidovudin
zidovudine
5
LamivudinePhase 2, Phase 3605134678-17-460825
Synonyms:
(+/-) (Cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(+/-)-3TC
(+/-)-BCH-189
(+/-)-SddC
(-)-(2'R,5'S)-1-[2'-Hydroxymethyl-5'-(1,3-oxathiolanyl)]cytosine
(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
(-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-2'-Deoxy-3'-thiacytidine
(-)-BCH 189
(-)-BCH-189
(-)-SddC
(-)-beta-L-2',3'-Dideoxy-3'-thiacytidine
(-)NGPB-21
(2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
.beta.-L-(-)-2',3'-dideoxy-3'-thiacytidine & Sho-Saiko-To
134678-17-4
2',3' Dideoxy 3' thiacytidine
2',3'-Dideoxy-3'-thiacytidine
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (+/-) (Cis)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Galanthus Nivalis Agglutinin (GNA)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Hippeastrum hybrid agglutinin( HHA)
3'-Thia-2',3'-dideoxycytidine
3TC
3TC & GNA
3TC & SST
3TC (AIDS INITIATIVE) (AIDS INITIATIVE)
3TC and NV-01
3TC, Zeffix, Heptovir, Epivir, Epivir-HBV, Lamivudine
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
480434-79-5
AC-1416
AC1L1TZZ
AC1Q6C34
BCH 189
BCH-189
BCH-790
BCH189
BIDD:GT0033
Bio-0652
C07065
C8H11N3O3S
CCRIS 9274
CHEBI:133986
CHEMBL141
CID60825
CPD000466319
D00353
D019259
 
DB00709
DRG-0126
DTHC
Epivir
Epivir (TN)
Epivir(TM)
Epivir-HBV
Epzicom
FT-0082667
GG-714
GR 109714X
GR-109714X
GR109714X
HHA & 3TC
HHA & Lamivudine
HMS2051D21
HSDB 7155
Hepitec
Heptivir
Heptodin
Heptovir
L0217
LMV
LS-2107
Lamivir
Lamivudin
Lamivudina
Lamivudine
Lamivudine & GNA
Lamivudine (JAN/USP/INN)
Lamivudine [USAN:BAN:INN]
Lamivudine [USAN:INN:BAN]
Lamivudine [Usan:Ban:Inn]
Lamivudine, (2S-cis)-Isomer
Lamivudinum
MLS000759424
MLS001424097
MolPort-002-507-347
NCGC00159341-03
NCGC00159341-04
NSC620753
S1706_Selleck
SAM001246582
SAM002589994
SMR000466319
STK801940
UNII-2T8Q726O95
ZINC00012346
Zeffix
Zefix
beta-L-2',3'-Dideoxy-3'-thiacytidine
beta-L-3'-Thia-2',3'-dideoxycytidine
lamivudine
6interferonsPhase 22112
7
Interferon beta-1aPhase 2195145258-61-36438354
Synonyms:
145258-61-3
Avonex
Avonex (TN)
Belerofon
D04554
 
Fibroblast interferon
IFN-beta
Interferon beta precursor
Interferon beta-1a
Interferon beta-1a (USAN)
Interferon beta-1a (genetical recombination)
Interferon beta-1a (genetical recombination) (JAN)
8
infliximabPhase 2364170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)CompletedNCT00773292Phase 2, Phase 3
2Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised TrialCompletedNCT00272480Phase 2, Phase 3
3Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) DiseasesCompletedNCT01472263Phase 3
4Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM)CompletedNCT00681980Phase 3
5Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)Active, not recruitingNCT01343355Phase 2, Phase 3
6Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM)CompletedNCT00001785Phase 2
7The HAM Infliximab StudyTerminatedNCT00823641Phase 2
8Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic ParaparesisRecruitingNCT00076843Phase 1
9MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic ParaparesisCompletedNCT00034723
10A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective DermatitisCompletedNCT00340821
11Assessment of Patients With Multiple Sclerosis (MS)CompletedNCT00001156
12Raltegravir for HAM/TSPRecruitingNCT01867320Phase 0
13Evaluation of Patients With HAM/TSPRecruitingNCT00001778
14Urological Physical Therapy in HTLV-1 With Urinary SymptomsEnrolling by invitationNCT01651819
15Evaluation of the MP Diagnostics HTLV Blot 2.4Enrolling by invitationNCT01467024
16Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 InfectionNot yet recruitingNCT02655471Phase 0
17Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1Not yet recruitingNCT01754311
18Safety and Efficiency Study of Valproic Acid In HAM/TSPTerminatedNCT00519181

Search NIH Clinical Center for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Genetic Tests for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Anatomical Context for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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MalaCards organs/tissues related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

34
T cells, Brain, B cells, Spinal cord

Animal Models for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis or affiliated genes

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MGI Mouse Phenotypes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

39 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.1HLA-DQB1, IFNG, IL2, JUN, MYC, NFKB1
2MP:00107717.9CD274, CX3CR1, IFNG, JUN, MYC, NFKB1
3MP:00053817.8CX3CR1, HLA-DQB1, IFNG, IL2, IL2RA, MYC
4MP:00053887.7CXCR3, HLA-DQB1, IFNG, IL2, JUN, NFKB1
5MP:00053857.3CX3CR1, CXCR3, HLA-DQB1, IFNG, IL2, JUN
6MP:00028737.2CX3CR1, CXCR3, HLA-DQB1, IFNG, JUN, MYC
7MP:00053866.5CD274, CX3CR1, HLA-DQB1, IFNG, IL2, JUN
8MP:00053766.2CD274, CX3CR1, CXCR3, HLA-DQB1, IFNG, IL2
9MP:00053846.1CD274, CX3CR1, CXCR3, HLA-DQB1, IFNG, IL2
10MP:00107685.9CD274, CX3CR1, CXCR3, HLA-DQB1, IFNG, IL2
11MP:00053875.5CD274, CX3CR1, CXCR3, HLA-DQB1, IFNG, IFNL3
12MP:00053975.4CD274, CX3CR1, CXCR3, HLA-DQB1, IFNG, IFNL3

Publications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Articles related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

(show all 24)
idTitleAuthorsYear
1
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (25884435)
2015
2
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. (24472094)
2014
3
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (25227931)
2014
4
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. (23932323)
2013
5
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. (23278610)
2013
6
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. (22720101)
2012
7
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
8
HTLV-1 associated myelopathy/tropical spastic paraparesis: how far have we come? (22519224)
2011
9
Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina. (20572090)
2010
10
Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). (20169122)
2010
11
Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population. (20851016)
2010
12
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (19228429)
2009
13
Is human T cell lymphotropic type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) syndrome a neglected disease? (19936247)
2009
14
High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. (19578703)
2009
15
Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease. (17884099)
2008
16
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. (17717136)
2007
17
Nocturnal hypertension and autonomic dysfunction due to human T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (16503269)
2006
18
Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. (17034574)
2006
19
Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. (15722539)
2005
20
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. (15961107)
2005
21
HTLV-1 associated myelopathy/tropical spastic paraparesis in Egypt. (8912212)
1996
22
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis. (8555734)
1995
23
Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil. (8372632)
1993
24
HTLV-1 associated myelopathy/tropical spastic paraparesis with adult T-cell leukemia. (1736016)
1992

Variations for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Expression for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis.

Pathways for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Pathways related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idSuper pathwaysScoreTop Affiliating Genes
19.7HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
29.5IL2RA, MYC, NFKB1
39.4JUN, MYC, NFKB1
49.4JUN, MYC, NFKB1
5
Show member pathways
9.4CD274, HLA-DQB1, HLA-DRB1, PDCD1
6
Show member pathways
9.4CD274, HLA-DQB1, HLA-DRB1, PDCD1
79.3IL2, JUN, NFKB1
8
Show member pathways
9.2IL2, IL2RA, MYC, NFKB1
99.1HLA-DRB1, IFNG, IL2
109.0CD274, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, PDCD1
118.9IFNG, JUN, VDR
12
Show member pathways
8.9IFNG, IL2, IL2RA
13
Show member pathways
8.9IL2, IL2RA, JUN, NFKB1
148.9IFNG, IL2, IL2RA
15
Show member pathways
8.9HLA-A, HLA-B, IFNG, IL2
168.8CD274, IL2RA, NFKB1, PDCD1, TNFRSF4
17
Show member pathways
8.8HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, IFNG
18
Show member pathways
8.8IFNG, JUN, NFKB1
198.8IFNG, JUN, NFKB1
20
Show member pathways
8.8IFNG, IL2RA, JUN
218.7HLA-DQB1, HLA-DRB1, IFNG, NFKB1, VDR
228.7HLA-DQB1, HLA-DRB1, IFNG, JUN
23
Show member pathways
8.7IL2, IL2RA, JUN, MYC, NFKB1
248.7IFNG, IL2, IL2RA, TNFRSF4
25
Show member pathways
8.6HLA-DQB1, HLA-DRB1, IL2, IL2RA, JUN, MYC
26
Show member pathways
8.5HLA-DQB1, HLA-DRB1, IL2, IL2RA, JUN, NFKB1
278.5IFNG, IL2, JUN, NFKB1
288.5IFNG, IL2, JUN, NFKB1
29
Show member pathways
8.4HLA-DQB1, HLA-DRB1, IFNG, JUN, NFKB1
30
Show member pathways
8.4IFNG, IL2, IL2RA, JUN
318.4CX3CR1, IFNG, IL2, IL2RA, KLRK1
32
Show member pathways
8.3IFNG, IL2, JUN, NFKB1, PDCD1
338.2IFNG, IL2, JUN, MYC, NFKB1
348.2IFNG, IL2, JUN, NFKB1, TNFRSF4
358.2HLA-DRB1, IFNG, IL2, IL2RA, JUN
368.2CXCR3, IFNG, IL2, IL2RA, KLRK1
37
Show member pathways
8.2IFNG, IL2, IL2RA, JUN, MYC
38
Show member pathways
8.1HLA-A, HLA-B, IFNG, IL2, JUN, KLRK1
39
Show member pathways
8.1IFNG, IFNL3, IL2, IL2RA, MYC
40
Show member pathways
8.0HLA-A, IFNG, IL2, IL2RA, JUN, TNFRSF4
417.9HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, IL2, IL2RA
427.8HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, IFNG, JUN
43
Show member pathways
7.7HLA-A, HLA-DRB1, IFNG, IL2, IL2RA, JUN
44
Show member pathways
7.7HLA-DQB1, HLA-DRB1, IFNG, IL2, IL2RA, JUN
457.7CD274, IFNG, IL2, IL2RA, NFKB1, PDCD1
46
Show member pathways
7.7HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, IFNG, IL2
47
Show member pathways
7.4HLA-DQB1, HLA-DRB1, IFNG, IL2, IL2RA, JUN
48
Show member pathways
7.3HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, IFNG, IL2
49
Show member pathways
6.1CX3CR1, CXCR3, IFNG, IFNL3, IL2, IL2RA
50
Show member pathways
5.2CD274, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, IFNG

GO Terms for genes affiliated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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Cellular components related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:004261210.6HLA-A, HLA-B
2integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.2HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:001250710.1HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
4neurofilamentGO:00058839.9NEFH, NEFL
5cell surfaceGO:00099868.0CD274, CXCR3, HLA-A, HLA-B, HLA-DRB1, IL2RA
6external side of plasma membraneGO:00098978.0CD274, CXCR3, IFNG, IL2RA, KLRK1, PDCD1

Biological processes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:000248010.7HLA-A, HLA-B
2cellular response to carbohydrate stimulusGO:007132210.6MYC, NFKB1
3positive regulation of immunoglobulin secretionGO:005102410.5IL2, TNFRSF4
4response to sodium arseniteGO:190393510.5NEFH, NEFL
5intermediate filament bundle assemblyGO:004511010.5NEFH, NEFL
6neurofilament bundle assemblyGO:003369310.5NEFH, NEFL
7regulation of T cell homeostatic proliferationGO:004601310.5IL2, IL2RA
8response to acrylamideGO:190393710.5NEFH, NEFL
9negative regulation of lymphocyte proliferationGO:005067210.4IL2, IL2RA
10neurofilament cytoskeleton organizationGO:006005210.3NEFH, NEFL
11negative regulation of inflammatory responseGO:005072810.0IL2, IL2RA, NFKB1
12positive regulation of isotype switching to IgG isotypesGO:00483049.9IFNG, IL2
13antigen processing and presentationGO:00198829.7HLA-A, HLA-B, IFNG
14interferon-gamma-mediated signaling pathwayGO:00603339.4HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, IFNG
15MAPK cascadeGO:00001659.3IL2, IL2RA, MYC, NEFL
16regulation of immune responseGO:00507769.3HLA-A, HLA-B, IFNG, KLRK1
17T cell receptor signaling pathwayGO:00508529.3HLA-DQB1, HLA-DRB1, IFNG, NFKB1
18cellular response to lipopolysaccharideGO:00712229.2CX3CR1, IFNG, KLRK1, NFKB1
19T cell costimulationGO:00312959.0CD274, HLA-DQB1, HLA-DRB1, KLRK1, PDCD1
20immune responseGO:00069558.8CD274, HLA-DQB1, IL2, IL2RA, TNFRSF4
21positive regulation of T cell proliferationGO:00421028.5CD274, IFNG, IL2, IL2RA
22negative regulation of apoptotic processGO:00430668.5IL2, JUN, MYC, NFKB1, PDCD1

Molecular functions related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.9HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
2protein heterodimerization activityGO:00469828.7JUN, MYC, NEFH, NEFL, NFKB1

Sources for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet