HHV8
MCID: HMN032
MIFTS: 46

Human Herpesvirus 8 (HHV8) malady

Categories: Cancer diseases

Aliases & Classifications for Human Herpesvirus 8

Aliases & Descriptions for Human Herpesvirus 8:

Name: Human Herpesvirus 8 54
Human Herpesvirus 8, Susceptibility to 13
Kaposi Sarcoma 69
Hhv8 45

Classifications:



External Ids:

OMIM 54 614836

Summaries for Human Herpesvirus 8

OMIM : 54 Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi sarcoma, primary effusion lymphoma, and some forms of... (614836) more...

MalaCards based summary : Human Herpesvirus 8, also known as human herpesvirus 8, susceptibility to, is related to hepatitis and kaposi sarcoma, and has symptoms including exanthema and pruritus. An important gene associated with Human Herpesvirus 8 is HHV8S (Human Herpesvirus 8, Susceptibility To), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Bleomycin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, lung and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and neoplasm

Related Diseases for Human Herpesvirus 8

Diseases related to Human Herpesvirus 8 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
id Related Disease Score Top Affiliating Genes
1 hepatitis 29.5 HLA-A HLA-B HLA-C IL6
2 kaposi sarcoma 11.9
3 sarcoma 10.4
4 lymphoma 10.3
5 primary effusion lymphoma 10.3
6 solid pseudopapillary carcinoma of pancreas 10.3 HLA-A HLA-B
7 sacral nerve root cysts 10.2 HLA-A HLA-B
8 myopathy, congenital nonprogressive, with moebius sequence and robin sequence 10.2 HLA-A HLA-B
9 epididymo-orchitis 10.2 HLA-A HLA-B HLA-C
10 hernia of ovary and fallopian tube 10.2 HLA-A HLA-B
11 learning disability 10.2 HLA-A HLA-B HLA-C
12 bickerstaff brainstem encephalitis 10.2 HLA-A HLA-B HLA-C
13 anaerobic meningitis 10.2 HLA-A HLA-B HLA-C
14 aortic coarctation 10.1 HLA-A HLA-B IL6
15 autosomal recessive congenital methemoglobinemia 10.1 HLA-A HLA-B HLA-C
16 nystagmus, congenital motor, autosomal recessive 10.1 HLA-A HLA-B
17 gonococcal endophthalmia 10.1 HLA-A HLA-B IL6
18 folinic acid-responsive seizures 10.1 HLA-A HLA-B HLA-C
19 acute allergic sanguinous otitis media 10.1 BCL2 IL6
20 psoriasis susceptibility 1 10.1 HLA-A HLA-B HLA-C
21 central nervous system lymphoma 10.1 HLA-A HLA-B IL6
22 anterior corneal pigmentation 10.1 HLA-A HLA-B HLA-C
23 swine influenza 10.1 HLA-B IL6
24 bubonic plague 10.1 HLA-A HLA-B
25 pemphigus vulgaris, familial 10.1 HLA-A HLA-B IL6
26 orbital osteomyelitis 10.0 HLA-A HLA-B HLA-C IL6
27 goodpasture syndrome 10.0 HLA-A HLA-B HLA-C IL6
28 cataract, total congenital 10.0 IL6 IL6R KRT15
29 endotheliitis 10.0
30 saethre-chotzen syndrome 9.9 IL6 IL6R RBFOX2
31 leukemia 9.9
32 pulmonary hypertension 9.9
33 exophthalmos 9.8 IL6 IRF1 IRF7
34 esophagus leiomyoma 9.8 IRF1 IRF7
35 pneumonia 9.8
36 primary cutaneous anaplastic large cell lymphoma 9.8
37 parapsoriasis 9.8
38 pemphigus 9.8
39 aids dementia complex 9.8
40 mycosis fungoides 9.8
41 dementia 9.8
42 castleman disease 9.8
43 poems syndrome 9.8
44 anaplastic large cell lymphoma 9.8
45 prostatitis 9.8
46 plasma cell leukemia 9.8
47 common variable immunodeficiency 9.6
48 squamous cell carcinoma 9.6
49 granuloma annulare 9.6
50 hepatitis c 9.6

Graphical network of the top 20 diseases related to Human Herpesvirus 8:



Diseases related to Human Herpesvirus 8

Symptoms & Phenotypes for Human Herpesvirus 8

Clinical features from OMIM:

614836

UMLS symptoms related to Human Herpesvirus 8:


exanthema, pruritus

GenomeRNAi Phenotypes related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.75 HLA-B HLA-C HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.75 HLA-C HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.75 HLA-B HLA-C HLA-A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.75 HLA-C IL6R
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.75 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.75 HLA-B HLA-C HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.75 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.75 HLA-B HLA-C HLA-A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.75 HLA-B HLA-C HLA-A IL6R
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.75 HLA-C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.75 HLA-C HLA-A HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-37 10.75 IL6R
13 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.75 HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.75 HLA-B HLA-C HLA-A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.75 HLA-B HLA-C HLA-A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.75 HLA-C

MGI Mouse Phenotypes related to Human Herpesvirus 8:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 BCL2 IL6 IL6R IRF1 IRF8

Drugs & Therapeutics for Human Herpesvirus 8

Drugs for Human Herpesvirus 8 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 209)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved Phase 4,Phase 3,Phase 2,Phase 1 11056-06-7 5360373
2
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
3
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
4
Efavirenz Approved, Investigational Phase 4,Phase 3 154598-52-4 64139
5
Ritonavir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 155213-67-5 392622
6
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3 134678-17-4 60825
7
Nevirapine Approved Phase 4,Phase 3 129618-40-2 4463
8
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
9
Emtricitabine Approved, Investigational Phase 4,Phase 3 143491-57-0 60877
10
Lopinavir Approved Phase 4,Phase 2,Phase 3 192725-17-0 92727
11
Tenofovir Approved, Investigational Phase 4,Phase 3 147127-20-6 464205
12
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 1 82410-32-0 3454
13
Valganciclovir Approved, Investigational Phase 4,Phase 2 175865-60-8 64147
14
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
15 Anti-HIV Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
16 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
17 Anti-Retroviral Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
18 Antiviral Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
19 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
20
protease inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
21 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1
22 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 3,Phase 2
23 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
24 Reverse Transcriptase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
25 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3
26 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
27 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3
28 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4,Phase 3
29 Acyclovir Phase 4,Phase 3,Phase 2,Phase 1
30 valacyclovir Phase 4,Phase 3,Phase 2,Phase 1
31 Ganciclovir triphosphate Phase 4,Phase 2,Phase 1
32
Meloxicam Approved, Vet_approved Phase 3 71125-38-7 5281106 54677470
33
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
34
Abacavir Approved, Investigational Phase 2, Phase 3 136470-78-5 65140 441300
35
Zidovudine Approved Phase 2, Phase 3, Phase 1 30516-87-1 35370
36
Daunorubicin Approved Phase 3,Phase 1 20830-81-3 30323
37
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
38
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
39 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
40 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
41 Antimitotic Agents Phase 3,Phase 2,Phase 1
42 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
43 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
44 Analgesics Phase 3,Phase 2,Phase 1
45 Analgesics, Non-Narcotic Phase 3,Phase 2,Phase 1
46 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
47 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 1,Phase 2
48 Antirheumatic Agents Phase 3,Phase 2,Phase 1
49 Cyclooxygenase 2 Inhibitors Phase 3
50 Cyclooxygenase Inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 191)
id Name Status NCT ID Phase
1 HIV/AIDS Kaposis Sarcoma: Comparison of Response to HAART vs HAART Plus CXT Completed NCT00380770 Phase 4
2 Anti-Retrovirals for Kaposi's Sarcoma Completed NCT00444379 Phase 4
3 Organ Transplant Infection Prevention and Detection Project Completed NCT00177801 Phase 4
4 Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT01346475 Phase 4
5 Valganciclovir to Reduce T Cell Activation in HIV Infection Completed NCT00264290 Phase 4
6 Valganciclovir to Treat HHV-8 Associated Multicentric Castleman's Disease Withdrawn NCT00361933 Phase 4
7 A Comparison of DOX-SL Versus Adriamycin Plus Bleomycin Plus Vincristine in the Treatment of Severe AIDS-Related Kaposi's Sarcoma Unknown status NCT00002318 Phase 3
8 TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial Unknown status NCT02060006 Phase 3
9 (Men Who Have Sex With Men) MSM Community Intervention Trial Unknown status NCT01068015 Phase 3
10 Paclitaxel Compared With Doxorubicin in Treating Patients With Advanced AIDS-Related Kaposi's Sarcoma Completed NCT00003350 Phase 3
11 A Pilot Study Of the Effects of Highly Active Antiretroviral Therapy on Kaposi's Sarcoma in Zimbabwe Completed NCT00834457 Phase 2, Phase 3
12 Doxorubicin in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00002985 Phase 3
13 A Study of DOX-SL in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00002319 Phase 3
14 Use of Stealth Liposomal Doxorubicin HCl ( DOX-SL ) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma. Completed NCT00002147 Phase 3
15 Safety and Effectiveness of an Experimental Drug, IM862, in Treating Kaposi's Sarcoma in AIDS Patients Completed NCT00002445 Phase 3
16 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00002105 Phase 3
17 A Study of AZT in HIV-Infected Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00000994 Phase 3
18 A Randomized Phase III Clinical Trial of Daunoxome Versus Combination Chemotherapy With Adriamycin/Bleomycin/Vincristine (ABV) in the Treatment of HIV-Associated Kaposi's Sarcoma. Completed NCT00002093 Phase 3
19 Valaciclovir to Prevent Transmission of Herpes Simplex Virus Completed NCT00001649 Phase 3
20 Acyclovir in Preventing Herpes Simplex Virus Infection in Patients With Neutropenia Completed NCT00855309 Phase 3
21 Can Valacyclovir Attenuate Inflammation in Antiretroviral-Treated HIV-Infected Individuals With Herpes Simplex Virus Type 2? Completed NCT01176409 Phase 3
22 Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates Completed NCT00031460 Phase 3
23 Long Term Treatment of Herpes Simplex Encephalitis (HSE) With Valacyclovir Completed NCT00031486 Phase 3
24 A Study of 2 Doses of Menactra®, a Meningococcal Conjugate Vaccine in Healthy Toddlers Completed NCT00384397 Phase 3
25 Three Chemo Regimens as an Adjunct to ART for Treatment of Advanced AIDS-KS Recruiting NCT01435018 Phase 3
26 Antiretroviral Therapy (ART) Alone or With Delayed Chemo Versus ART With Immediate Chemo for Limited AIDS-related Kaposi's Sarcoma Active, not recruiting NCT01352117 Phase 3
27 Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone Active, not recruiting NCT01924286 Phase 3
28 A Study of Selumetinib in Patients With Kaposi's Sarcoma Unknown status NCT01752569 Phase 1, Phase 2
29 Antiviral Therapy in Treating Patients With Slowly Progressing HIV-Related Kaposi's Sarcoma Unknown status NCT00003419 Phase 2
30 Sorafenib and Paclitaxel in Treating Patients With Metastatic Breast Cancer Unknown status NCT00622466 Phase 2
31 Suppression of Oral HHV8 Shedding With Valganciclovir Completed NCT00194467 Phase 2
32 Treatment With Indinavir and Chemotherapy for Advanced Classical Kaposi's Sarcoma Completed NCT01067690 Phase 2
33 Intralesional Bevacizumab for Treating AIDS-associated Kaposi´s Sarcoma of the Larynx, Pharynx and Oral Cavity Completed NCT01296815 Phase 2
34 Halofuginone Hydrobromide in Treating Patients With HIV-Related Kaposi's Sarcoma Completed NCT00064142 Phase 2
35 Treatment of Classical Non-HIV-Related Kaposi's Sarcoma With the Antiviral Drug Indinavir Completed NCT00362310 Phase 2
36 Bevacizumab to Treat Kaposi's Sarcoma in HIV-Positive and HIV-Negative Patients Completed NCT00055237 Phase 2
37 Interleukin-12 in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00019188 Phase 1, Phase 2
38 Lenalidomide in Treating Patients With AIDS-Associated Kaposi's Sarcoma Completed NCT01057121 Phase 1, Phase 2
39 BMS-275291 in Treating Patients With HIV-Related Kaposi's Sarcoma Completed NCT00024024 Phase 1, Phase 2
40 Nicotine Skin Patch in Treating Patients With Kaposi's Sarcoma Completed NCT00295984 Phase 2
41 Imatinib Mesylate in Treating Patients With HIV-Related Kaposi's Sarcoma Completed NCT00090987 Phase 2
42 SU5416 in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00005042 Phase 2
43 Antiviral Therapy in Treating Patients With Kaposi's Sarcoma With or Without HIV Infection Completed NCT00019240 Phase 2
44 Thalidomide in Treating Patients With HIV-Associated Kaposi's Sarcoma Completed NCT00019123 Phase 2
45 Paclitaxel in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00003008 Phase 2
46 Liposomal Doxorubicin and Interleukin-12 in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00020449 Phase 2
47 A Study to Investigate ALDOXORUBICIN in HIV-infected Subjects With Kaposi's Sarcoma Completed NCT02029430 Phase 2
48 Evaluation of Tc 99m Tilmanocept Localization in Primary Cutaneous Kaposi's Sarcoma and Lymphatic Drainage by SPECT/CT Completed NCT02201420 Phase 2
49 A Study of ALRT1057 in Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00002188 Phase 2
50 A Pilot Study of OPC-8212 (Vesnarinone) in Persons With AIDS-Related Kaposi's Sarcoma Completed NCT00002131 Phase 2

Search NIH Clinical Center for Human Herpesvirus 8

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Human Herpesvirus 8

Anatomical Context for Human Herpesvirus 8

MalaCards organs/tissues related to Human Herpesvirus 8:

39
Endothelial, Lung, T Cells, B Cells, Prostate, Skin, Lymph Node

Publications for Human Herpesvirus 8

Articles related to Human Herpesvirus 8:

(show top 50) (show all 131)
id Title Authors Year
1
Human herpesvirus 8 infection contributes to a T helper 2 immune response in men from Tobago with prostate cancer. ( 27734534 )
2017
2
Is human herpesvirus 8 infection more common in men than in women? Systematic review and meta-analysis. ( 27062038 )
2016
3
Relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila pneumoniae and human herpesvirus 8 infection. ( 27382410 )
2016
4
Human herpesvirus 8 establishes a latent infection in prostates of Tobago men resulting in increased macrophage infiltration. ( 26848067 )
2016
5
High Prevalence of Human Herpesvirus 8 Infection in Diabetes Type 2 Patients and Detection of a New Virus Subtype. ( 27864801 )
2016
6
HIV and human herpesvirus 8 co-infection across the globe: Systematic review and meta-analysis. ( 26175054 )
2016
7
No Evidence of Human Herpesvirus 8 among Iranian Patients Infected with HIV. ( 27517001 )
2016
8
Molecular typing of human herpesvirus 8 among HIV positive in comparison to HIV-negative individuals in Iran. ( 27463857 )
2016
9
High seroprevalence of human herpesvirus 8 and herpes simplex virus 2 infections in men who have sex with men in Shanghai, China. ( 27769110 )
2016
10
Prevalence of Human herpesvirus 8 infection in people living with HIV/AIDS in Pernambuco, Brazil. ( 27089548 )
2016
11
Development of Kaposi sarcoma and hemophagocytic lymphohistiocytosis associated with human herpesvirus 8 in a renal transplant recipient. ( 26842102 )
2016
12
Human herpesvirus 8 (HHV-8) detected by nested polymerase chain reaction (PCR) in HIV patients with or without Kaposi's sarcoma. An analytic cross-sectional study. ( 25885486 )
2015
13
Modulation of the Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1. ( 26512076 )
2015
14
Human herpesvirus 8 seroconversion in a population-based cohort of men in Tobago. ( 25612304 )
2015
15
Identification of Human Herpesvirus 8 Sequences in Conjunctiva Intraepithelial Neoplasia and Squamous Cell Carcinoma of Ugandan Patients. ( 26509162 )
2015
16
The Role of Human Herpesvirus 8 in Diabetes Mellitus Type 2: State of the Art and a Medical Hypothesis. ( 26542602 )
2015
17
Resveratrol induces cell death and inhibits human herpesvirus 8 replication in primary effusion lymphoma cells. ( 26549478 )
2015
18
Human Herpesvirus 8 Interleukin-6 Contributes to Primary Effusion Lymphoma Cell Viability via Suppression of Proapoptotic Cathepsin D, a Cointeraction Partner of Vitamin K Epoxide Reductase Complex Subunit 1 Variant 2. ( 24198402 )
2014
19
Human herpesvirus 8 glycoprotein B binds the entry receptor DC-SIGN. ( 25018023 )
2014
20
Seroprevalence and Determinants of Kaposi Sarcoma-Associated Human Herpesvirus 8 in Indian HIV-Infected Males. ( 25375960 )
2014
21
Human herpesvirus 8 viral interleukin-6 signaling through gp130 promotes virus replication in primary effusion lymphoma and endothelial cells. ( 25078695 )
2014
22
Kikuchi-Fujimoto lymphadenitis: role of parvovirus B-19, Epstein-Barr virus, human herpesvirus 6, and human herpesvirus 8. ( 22939574 )
2013
23
Role of human herpesvirus 8 interleukin-6-activated gp130 signal transducer in primary effusion lymphoma cell growth and viability. ( 23903842 )
2013
24
Primary effusion lymphoma-like lymphoma unrelated to human herpesvirus 8 with aggressive clinical course in patient receiving cyclosporine. ( 23775963 )
2013
25
Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report. ( 24099147 )
2013
26
Development of whole-virus multiplex luminex-based serological assays for diagnosis of infections with kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 homologs in macaques. ( 23345584 )
2013
27
High seroprevalence of human herpesvirus 8 infection in patients with systemic lupus erythematosus. ( 24283670 )
2013
28
Human herpesvirus 8 is not detectable in lesions of large plaque parapsoriasis, and in early-stage sporadic, familial, and juvenile cases of mycosis fungoides. ( 21704421 )
2012
29
Molecular epidemiology of human herpesvirus 8 variants in Kaposi's sarcoma from Iranian patients. ( 21963664 )
2012
30
Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties. ( 22016052 )
2012
31
Human herpesvirus 8 viral interleukin-6 interacts with splice variant 2 of vitamin K epoxide reductase complex subunit 1. ( 22130532 )
2012
32
Kaposi's Sarcoma and Human Herpesvirus 8 in Cuba: evidence of subtype B expansion. ( 22795824 )
2012
33
Detection of human herpesvirus 8 by quantitative polymerase chain reaction: development and standardisation of methods. ( 22963082 )
2012
34
Cisplatin disrupts the latency of human herpesvirus 8 and induces apoptosis in primary effusion lymphoma cells. ( 22480174 )
2012
35
Human herpesvirus 8 in corneal endotheliitis resulting in graft failure after penetrating keratoplasty refractory to allograft rejection therapy. ( 22159687 )
2011
36
Seroprevalence of Human herpesvirus 8 (HHV-8) and incidence of Kaposi's sarcoma in Iran. ( 21527020 )
2011
37
Prevalence of human herpesvirus 8 DNA in peripheral blood mononuclear cells of acute and chronic leukemia patients in Taiwan. ( 21392127 )
2011
38
Lysine residues of interferon regulatory factor 7 affect the replication and transcription activator-mediated lytic replication of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. ( 20844090 )
2011
39
Simultaneous quantification of human herpesvirus 8 DNA by real time PCR in different tissues of HIV infected cuban patients with Kaposi's sarcoma. ( 21429238 )
2010
40
Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the "Kaposi's sarcoma belt". ( 20143397 )
2010
41
Seroprevalence of human herpesvirus 8 infection in individuals from health care centers in Mozambique: potential for endemic and epidemic Kaposi's sarcoma. ( 20513087 )
2010
42
Human herpesvirus 8 viral FLICE-inhibitory protein retards cell proliferation via downregulation of Id2 and Id3 expression. ( 20512523 )
2010
43
Induction of angiogenic chemokine CCL2 by human herpesvirus 8 chemokine receptor. ( 20004457 )
2010
44
Patterns of antibodies against latent and lytic antigens of human herpesvirus 8 in an endemic population and patients with Kaposi's sarcoma in Mozambique. ( 20648612 )
2010
45
A systems biology approach to identify the combination effects of human herpesvirus 8 genes on NF-kappaB activation. ( 19129458 )
2009
46
Mechanism of Fas signaling regulation by human herpesvirus 8 K1 oncoprotein. ( 19276446 )
2009
47
Detection of human herpesvirus 8 in the skin of patients with pityriasis rosea. ( 19997691 )
2009
48
Absence of human herpesvirus 8 in pemphigus and bullous pemphigoid. ( 19294004 )
2009
49
High association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides. ( 18711073 )
2008
50
The effects of human herpesvirus 8 infection and interferon-gamma response in cutaneous lesions of Kaposi sarcoma differ among human immunodeficiency virus-infected and uninfected individuals. ( 18644020 )
2008

Variations for Human Herpesvirus 8

Expression for Human Herpesvirus 8

Search GEO for disease gene expression data for Human Herpesvirus 8.

Pathways for Human Herpesvirus 8

Pathways related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 BCL2 HLA-A HLA-B HLA-C IL6 IL6R
2
Show member pathways
12.72 BCL2 HLA-A HLA-B HLA-C IL6 IL6R
3
Show member pathways
12.64 HLA-A HLA-B HLA-C IL6
4
Show member pathways
12.55 HLA-A HLA-B HLA-C IL6 IRF7
5
Show member pathways
12.23 HLA-A HLA-B HLA-C IRF1 IRF7 IRF8
6 12.19 HLA-A HLA-B HLA-C IL6
7 12.04 BCL2 HLA-A HLA-B HLA-C
8
Show member pathways
12.01 BCL2 IL6 IL6R
9 12.01 HLA-A HLA-B HLA-C IRF7
10 11.94 HLA-A HLA-B HLA-C
11 11.91 HLA-A HLA-B HLA-C
12 11.86 HLA-A HLA-B HLA-C
13 11.78 BCL2 IL6 IL6R
14 11.71 BCL2 IL6 IL6R
15
Show member pathways
11.62 IL6 IL6R IRF1
16 11.58 BCL2 IL6 IL6R IRF1 IRF7
17 11.55 IL6 IRF1 IRF8
18
Show member pathways
11.38 HLA-A HLA-B HLA-C IL6 IRF1 IRF7
19 11.12 IL6 IL6R
20 11.11 HLA-B IRF1 IRF8
21 10.9 HLA-A HLA-B HLA-C
22 10.85 BCL2 IL6

GO Terms for Human Herpesvirus 8

Cellular components related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 HLA-A HLA-B HLA-C IL6R
2 early endosome membrane GO:0031901 9.58 HLA-A HLA-B HLA-C
3 phagocytic vesicle membrane GO:0030670 9.54 HLA-A HLA-B HLA-C
4 recycling endosome membrane GO:0055038 9.5 HLA-A HLA-B HLA-C
5 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-A HLA-B HLA-C
6 interleukin-6 receptor complex GO:0005896 9.16 IL6 IL6R
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-A HLA-B HLA-C
8 MHC class I protein complex GO:0042612 8.8 HLA-A HLA-B HLA-C

Biological processes related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 HLA-A HLA-B HLA-C IL6 IRF8
2 viral process GO:0016032 9.89 HLA-A HLA-B HLA-C IRF7
3 immune system process GO:0002376 9.85 HLA-A HLA-B HLA-C IRF1 IRF7
4 defense response to virus GO:0051607 9.73 BCL2 IL6 IRF1 IRF7
5 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.72 HLA-A HLA-B HLA-C
6 response to cytokine GO:0034097 9.7 BCL2 IL6 IL6R
7 antigen processing and presentation GO:0019882 9.65 HLA-A HLA-B HLA-C
8 regulation of immune response GO:0050776 9.65 HLA-A HLA-B HLA-C IRF1 IRF7
9 acute-phase response GO:0006953 9.62 IL6 IL6R
10 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 9.62 IL6 IL6R
11 response to bacterium GO:0009617 9.61 IL6 IRF8
12 positive regulation of interferon-beta production GO:0032728 9.61 IRF1 IRF7
13 endocrine pancreas development GO:0031018 9.6 IL6 IL6R
14 defense response to protozoan GO:0042832 9.58 IL6 IRF8
15 positive regulation of chemokine production GO:0032722 9.58 IL6 IL6R
16 positive regulation of leukocyte chemotaxis GO:0002690 9.57 IL6 IL6R
17 interleukin-6-mediated signaling pathway GO:0070102 9.56 IL6 IL6R
18 regulation of adaptive immune response GO:0002819 9.54 IRF1 IRF7
19 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.5 HLA-A HLA-B HLA-C
20 protection from natural killer cell mediated cytotoxicity GO:0042270 9.49 HLA-A HLA-B
21 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-A HLA-B HLA-C IRF1 IRF7 IRF8
22 hepatic immune response GO:0002384 9.4 IL6 IL6R
23 regulation of MyD88-dependent toll-like receptor signaling pathway GO:0034124 9.37 IRF1 IRF7
24 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.33 HLA-A HLA-B HLA-C
25 type I interferon signaling pathway GO:0060337 9.1 HLA-A HLA-B HLA-C IRF1 IRF7 IRF8

Molecular functions related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.56 HLA-A HLA-B HLA-C IL6
2 interleukin-6 receptor binding GO:0005138 9.16 IL6 IL6R
3 peptide antigen binding GO:0042605 9.13 HLA-A HLA-B HLA-C
4 regulatory region DNA binding GO:0000975 8.8 IRF1 IRF7 IRF8

Sources for Human Herpesvirus 8

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....