Aliases & Classifications for Human Herpesvirus 8

MalaCards integrated aliases for Human Herpesvirus 8:

Name: Human Herpesvirus 8 54
Human Herpesvirus 8, Susceptibility to 13
Kaposi Sarcoma 69
Hhv8 45

External Ids:

OMIM 54 614836

Summaries for Human Herpesvirus 8

OMIM : 54
Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi sarcoma, primary effusion lymphoma, and some forms of multicentric Castleman disease (Pedergnana et al., 2012). See 148000 for general phenotypic information on these diseases, as well as information on HHV-8-associated pathogenesis. (614836)

MalaCards based summary : Human Herpesvirus 8, also known as human herpesvirus 8, susceptibility to, is related to hemophagocytic lymphohistiocytosis and kaposi sarcoma, and has symptoms including exanthema and pruritus. An important gene associated with Human Herpesvirus 8 is HHV8S (Human Herpesvirus 8, Susceptibility To), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Doxorubicin and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and b cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and adipose tissue

Related Diseases for Human Herpesvirus 8

Diseases related to Human Herpesvirus 8 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
id Related Disease Score Top Affiliating Genes
1 hemophagocytic lymphohistiocytosis 29.6 HLA-A HLA-B HLA-C IL6
2 kaposi sarcoma 11.9
3 autosomal recessive severe congenital neutropenia due to cxcr2 deficiency 10.7 HLA-A HLA-B
4 ramsay hunt syndrome i 10.7 HLA-A HLA-B
5 cardioskeletal syndrome, kuwaiti type 10.7 HLA-A HLA-B
6 hernia of ovary and fallopian tube 10.7 HLA-A HLA-B
7 thrombotic thrombocytopenic purpura 10.6 HLA-A HLA-B
8 not otherwise specified 3-mga-uria type 10.6 HLA-A HLA-B
9 antigen-peptide-transporter 2 deficiency 10.6 HLA-B IL6
10 aseptic meningitis 10.6 HLA-A HLA-B
11 acanthoma 10.6 HLA-A HLA-B
12 hemangioma-thrombocytopenia syndrome 10.5 HLA-A HLA-C
13 lens-induced iridocyclitis 10.5 HLA-A HLA-B HLA-C
14 progressive myoclonus epilepsy 10.4 HLA-A HLA-B HLA-C
15 sarcoma 10.4
16 mazabraud syndrome 10.4 HLA-A HLA-B HLA-C
17 anaerobic meningitis 10.4 HLA-A HLA-B HLA-C
18 acute necrotizing encephalopathy type 1 10.4 HLA-A HLA-B HLA-C
19 classic hairy cell leukemia 10.4 HLA-A HLA-B HLA-C
20 spondyloarthropathy 1 10.4 HLA-A HLA-B HLA-C
21 anterior corneal pigmentation 10.4 HLA-A HLA-B HLA-C
22 cyclosporiasis 10.4 HLA-B IL6
23 noma 10.4 HLA-A HLA-B IL6
24 emphysema, congenital lobar 10.4 HLA-A HLA-B IL6
25 lymphoma 10.4
26 muscle tissue disease 10.3 HLA-B HLA-C IL6
27 hypertrophy of breast 10.3 HLA-A HLA-B
28 primary effusion lymphoma 10.3
29 primary malignant melanoma of the conjunctiva 10.3 BCL6 IL6
30 solitary plasmacytoma of chest wall 10.3 BCL2 IL6
31 high pressure neurological syndrome 10.2 HLA-B IL6
32 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.2 BCL6 IL6
33 intracranial hemorrhage in brain cerebrovascular malformations 10.1 HLA-A IL6 IL6ST
34 thrombocytopenia, anemia, and myelofibrosis 10.1 BCL2 BCL6
35 orbital osteomyelitis 10.1 HLA-A HLA-B HLA-C IL6
36 pseudotyphus of california 10.1 BCL2 BCL6
37 acral lentiginous melanoma 10.1 BCL6 HLA-B IL6
38 blake pouch cyst 10.1 BCL2 BCL6
39 goodpasture syndrome 10.1 HLA-A HLA-B HLA-C IL6
40 blood group incompatibility 10.0 BCL2 HLA-C
41 primary malignant melanoma of the cervix 10.0 BCL2 BCL6
42 cataract congenital autosomal dominant 10.0 IL6 IL6R
43 pylorus cancer 10.0 BCL2 BCL6
44 endotheliitis 10.0
45 pancreatic cancer 10.0 BCL2 HLA-A HLA-B
46 paraneoplastic polyneuropathy 9.9 BCL2 BCL6
47 pulmonary hypertension 9.9
48 leukemia 9.9
49 hypocalciuric hypercalcemia, type i 9.9 HLA-A HLA-B IL6
50 parapsoriasis 9.8

Graphical network of the top 20 diseases related to Human Herpesvirus 8:



Diseases related to Human Herpesvirus 8

Symptoms & Phenotypes for Human Herpesvirus 8

Clinical features from OMIM:

614836

UMLS symptoms related to Human Herpesvirus 8:


exanthema, pruritus

GenomeRNAi Phenotypes related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.75 HLA-A HLA-B HLA-C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.75 HLA-B HLA-C HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.75 HLA-A HLA-B HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.75 HLA-C IL6R
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.75 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.75 HLA-B HLA-C HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.75 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.75 HLA-B HLA-C HLA-A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.75 HLA-B HLA-C HLA-A IL6R
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.75 HLA-C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.75 HLA-B HLA-C HLA-A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-37 10.75 IL6R
13 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.75 HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.75 HLA-A HLA-B HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.75 HLA-A HLA-B HLA-C
16 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.75 HLA-C

MGI Mouse Phenotypes related to Human Herpesvirus 8:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.35 BCL2 IL6 IL6R IL6ST TRIM63
2 neoplasm MP:0002006 8.92 BCL2 IL6 IL6R IL6ST

Drugs & Therapeutics for Human Herpesvirus 8

Drugs for Human Herpesvirus 8 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 188)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
3
Ritonavir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 155213-67-5 392622
4
Efavirenz Approved, Investigational Phase 4,Phase 3 154598-52-4 64139
5
Bleomycin Approved Phase 4,Phase 3,Phase 2,Phase 1 11056-06-7 5360373
6
Lopinavir Approved Phase 4,Phase 2,Phase 3 192725-17-0 92727
7
Nevirapine Approved Phase 4,Phase 3 129618-40-2 4463
8
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3 134678-17-4 60825
9
Ganciclovir Approved, Investigational Phase 4,Phase 2 82410-32-0 3454
10
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
11
Emtricitabine Approved, Investigational Phase 4,Phase 3 143491-57-0 60877
12
Valganciclovir Approved, Investigational Phase 4,Phase 2 175865-60-8 64147
13
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
14
protease inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
15 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
16 Anti-HIV Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
17 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
18 Anti-Retroviral Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
19 Antiviral Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
20
Tenofovir Phase 4,Phase 3 147127-20-6 464205
21 Acyclovir Phase 4,Phase 3,Phase 1
22 valacyclovir Phase 4,Phase 3
23 Reverse Transcriptase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
24 Ganciclovir triphosphate Phase 4,Phase 2
25 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3
26 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 3
27 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
28 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3
29 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
30 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4,Phase 3
31 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1
32
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
33
Meloxicam Approved, Vet_approved Phase 3 71125-38-7 5281106 54677470
34
Daunorubicin Approved Phase 3,Phase 1 20830-81-3 30323
35
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
36
Zidovudine Approved Phase 2, Phase 3, Phase 1 30516-87-1 35370
37
Abacavir Approved, Investigational Phase 2, Phase 3 136470-78-5 65140 441300
38
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
39 Analgesics Phase 3,Phase 2,Phase 1
40 Albumin-Bound Paclitaxel Phase 3,Phase 2
41 Cyclooxygenase 2 Inhibitors Phase 3
42 Cyclooxygenase Inhibitors Phase 3
43 Analgesics, Non-Narcotic Phase 3,Phase 2,Phase 1
44 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
45 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
46 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
47 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
48 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 1,Phase 2
49 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
50 Antirheumatic Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 166)

id Name Status NCT ID Phase Drugs
1 HIV/AIDS Kaposis Sarcoma: Comparison of Response to HAART vs HAART Plus CXT Completed NCT00380770 Phase 4 Generic HAART Triomune : d4T, 3TC, NVP;Generic HAART Triomune : d4T, 3TC, NVP and chemotherapy ABV
2 Anti-Retrovirals for Kaposi's Sarcoma Completed NCT00444379 Phase 4 Lopinavir/ritonavir plus Emtricitabine/Tenofovir versus Efavirenz plus Emtricitabine/Tenofovir
3 Organ Transplant Infection Prevention and Detection Project Completed NCT00177801 Phase 4
4 Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT01346475 Phase 4 valacyclovir;Valacyclovir
5 Valganciclovir to Treat HHV-8 Associated Multicentric Castleman's Disease Withdrawn NCT00361933 Phase 4 Valganciclovir
6 A Comparison of DOX-SL Versus Adriamycin Plus Bleomycin Plus Vincristine in the Treatment of Severe AIDS-Related Kaposi's Sarcoma Unknown status NCT00002318 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
7 TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial Unknown status NCT02060006 Phase 3 Meloxicam 7.5mg daily for 8 weeks
8 Paclitaxel Compared With Doxorubicin in Treating Patients With Advanced AIDS-Related Kaposi's Sarcoma Completed NCT00003350 Phase 3 paclitaxel;pegylated liposomal doxorubicin hydrochloride
9 A Pilot Study Of the Effects of Highly Active Antiretroviral Therapy on Kaposi's Sarcoma in Zimbabwe Completed NCT00834457 Phase 2, Phase 3 abacavir/3TC/zidovudine;abacavir /3TC plus ritonavir boosted lopinavir
10 Doxorubicin in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00002985 Phase 3 daunorubicin hydrochloride;pegylated liposomal doxorubicin hydrochloride
11 A Study of DOX-SL in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00002319 Phase 3 Doxorubicin hydrochloride (liposomal)
12 Use of Stealth Liposomal Doxorubicin HCl ( DOX-SL ) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma. Completed NCT00002147 Phase 3 Doxorubicin hydrochloride (liposomal)
13 Safety and Effectiveness of an Experimental Drug, IM862, in Treating Kaposi's Sarcoma in AIDS Patients Completed NCT00002445 Phase 3 IM862
14 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00002105 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate
15 A Study of AZT in HIV-Infected Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00000994 Phase 3 Zidovudine
16 A Randomized Phase III Clinical Trial of Daunoxome Versus Combination Chemotherapy With Adriamycin/Bleomycin/Vincristine (ABV) in the Treatment of HIV-Associated Kaposi's Sarcoma. Completed NCT00002093 Phase 3 Daunorubicin (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
17 Valaciclovir to Prevent Transmission of Herpes Simplex Virus Completed NCT00001649 Phase 3 Valaciclovir
18 Acyclovir in Preventing Herpes Simplex Virus Infection in Patients With Neutropenia Completed NCT00855309 Phase 3 acyclovir sodium
19 Can Valacyclovir Attenuate Inflammation in Antiretroviral-Treated HIV-Infected Individuals With Herpes Simplex Virus Type 2? Completed NCT01176409 Phase 3 Valacyclovir;Placebo
20 Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates Completed NCT00031460 Phase 3 Acyclovir;Placebo
21 Three Chemo Regimens as an Adjunct to ART for Treatment of Advanced AIDS-KS Recruiting NCT01435018 Phase 3 Coformulated EFV/FTC/TDF;Etoposide;Bleomycin and Vincristine (BV);Paclitaxel (PTX)
22 Antiretroviral Therapy (ART) Alone or With Delayed Chemo Versus ART With Immediate Chemo for Limited AIDS-related Kaposi's Sarcoma Active, not recruiting NCT01352117 Phase 3 efavirenz/emtricitabine/tenofovir disoproxil fumarate;etoposide
23 Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone Active, not recruiting NCT01924286 Phase 3 Prednisone;Placebo
24 A Study of Selumetinib in Patients With Kaposi's Sarcoma Unknown status NCT01752569 Phase 1, Phase 2 Selumetinib
25 Antiviral Therapy in Treating Patients With Slowly Progressing HIV-Related Kaposi's Sarcoma Unknown status NCT00003419 Phase 2
26 Sorafenib and Paclitaxel in Treating Patients With Metastatic Breast Cancer Unknown status NCT00622466 Phase 2 paclitaxel;sorafenib tosylate
27 Suppression of Oral HHV8 Shedding With Valganciclovir Completed NCT00194467 Phase 2 valganciclovir;placebo
28 Treatment With Indinavir and Chemotherapy for Advanced Classical Kaposi's Sarcoma Completed NCT01067690 Phase 2 Indinavir in association with Vinblastina +/- Bleomicina
29 Intralesional Bevacizumab for Treating AIDS-associated Kaposi´s Sarcoma of the Larynx, Pharynx and Oral Cavity Completed NCT01296815 Phase 2 Bevacizumab
30 Halofuginone Hydrobromide in Treating Patients With HIV-Related Kaposi's Sarcoma Completed NCT00064142 Phase 2 halofuginone hydrobromide
31 Treatment of Classical Non-HIV-Related Kaposi's Sarcoma With the Antiviral Drug Indinavir Completed NCT00362310 Phase 2 indinavir
32 Bevacizumab to Treat Kaposi's Sarcoma in HIV-Positive and HIV-Negative Patients Completed NCT00055237 Phase 2
33 Interleukin-12 in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00019188 Phase 1, Phase 2 interleukin-12
34 Lenalidomide in Treating Patients With AIDS-Associated Kaposi's Sarcoma Completed NCT01057121 Phase 1, Phase 2 Lenalidomide
35 BMS-275291 in Treating Patients With HIV-Related Kaposi's Sarcoma Completed NCT00024024 Phase 1, Phase 2 rebimastat
36 Nicotine Skin Patch in Treating Patients With Kaposi's Sarcoma Completed NCT00295984 Phase 2 nicotine
37 Imatinib Mesylate in Treating Patients With HIV-Related Kaposi's Sarcoma Completed NCT00090987 Phase 2 imatinib mesylate
38 SU5416 in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00005042 Phase 2 semaxanib
39 Antiviral Therapy in Treating Patients With Kaposi's Sarcoma With or Without HIV Infection Completed NCT00019240 Phase 2 cidofovir
40 Thalidomide in Treating Patients With HIV-Associated Kaposi's Sarcoma Completed NCT00019123 Phase 2 thalidomide
41 Paclitaxel in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00003008 Phase 2 indinavir sulfate;nelfinavir mesylate;paclitaxel;ritonavir;saquinavir mesylate
42 Liposomal Doxorubicin and Interleukin-12 in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00020449 Phase 2 paclitaxel;pegylated liposomal doxorubicin hydrochloride
43 A Study to Investigate ALDOXORUBICIN in HIV-infected Subjects With Kaposi's Sarcoma Completed NCT02029430 Phase 2 aldoxorubicin
44 Evaluation of Tc 99m Tilmanocept Localization in Primary Cutaneous Kaposi's Sarcoma and Lymphatic Drainage by SPECT/CT Completed NCT02201420 Phase 2 Tc 99m tilmanocept
45 A Study of ALRT1057 in Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00002188 Phase 2 Alitretinoin
46 A Pilot Study of OPC-8212 (Vesnarinone) in Persons With AIDS-Related Kaposi's Sarcoma Completed NCT00002131 Phase 2 Vesnarinone
47 The Safety and Effectiveness of Ritonavir in the Treatment of HIV-Related Kaposi's Sarcoma Completed NCT00002366 Phase 2 Ritonavir
48 A Study of Targretin Capsules in Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00002212 Phase 2 Bexarotene
49 Phase II Study of Intravenous Novantrone(R) in the Treatment of AIDS Related Kaposi's Sarcoma Completed NCT00002259 Phase 2 Mitoxantrone hydrochloride
50 The Safety and Effectiveness of Interferon Alfa-2B Plus Didanosine in Patients With Kaposi's Sarcoma Completed NCT00001114 Phase 2 Interferon alfa-2b;Didanosine

Search NIH Clinical Center for Human Herpesvirus 8

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Human Herpesvirus 8

Anatomical Context for Human Herpesvirus 8

MalaCards organs/tissues related to Human Herpesvirus 8:

39
Skin, Liver, B Cells, T Cells, Kidney, Testes, Breast

Publications for Human Herpesvirus 8

Articles related to Human Herpesvirus 8:

(show top 50) (show all 142)
id Title Authors Year
1
Regulatory T Cell Effect on CD8(+) T Cell Responses to Human Herpesvirus 8 Infection and Development of Kaposi's Sarcoma. ( 28121161 )
2017
2
Cross-sectional and longitudinal investigation of human herpesvirus 8 seroprevalence in HIV-1-infected individuals in Osaka, Japan. ( 28131739 )
2017
3
Human Herpesvirus 8 Interleukin-6 Interacts with Calnexin Cycle Components and Promotes Protein Folding. ( 28878084 )
2017
4
Effect of electrochemotherapy on human herpesvirus 8 kinetics in classic Kaposi sarcoma. ( 28649271 )
2017
5
Seroprevalence of Human Herpesvirus 8 and its Impact on the Hemoglobin Level in Patients of End Stage of Renal Diseases. ( 28876458 )
2017
6
Successful Treatment of Kaposi Sarcoma-Associated Herpesvirus Inflammatory Cytokine Syndrome After Kidney-Liver Transplant: Correlations With the Human Herpesvirus 8 miRNome and Specific T Cell Response. ( 28489271 )
2017
7
Elevated Serum PSA is Associated With Human Herpesvirus 8 Infection and Increased Circulating Cytokine Levels in Men From Tobago. ( 28117495 )
2017
8
Diversity of human herpesvirus 8 genotypes in patients with AIDS and non-AIDS associated Kaposi's sarcoma, Castleman's disease and primary effusion lymphoma in Argentina. ( 28617968 )
2017
9
Human herpesvirus 8 infection contributes to a T helper 2 immune response in men from Tobago with prostate cancer. ( 27734534 )
2017
10
Presence of human herpesvirus 8 (HHV-8) DNA sequences in patients with lymphoproliferative diseases and chronic blood disorders. ( 28916317 )
2017
11
High Seroprevalence of Human Herpesvirus 8 Infection in HIV-positive Homosexual Men in Jiangsu Province, China. ( 28606034 )
2017
12
Human Herpesvirus 8 Infects and Replicates in Langerhans Cells and Interstitial Dermal Dendritic Cells and Impairs Their Function. ( 28768873 )
2017
13
Prevalence of Human herpesvirus 8 infection in people living with HIV/AIDS in Pernambuco, Brazil. ( 27089548 )
2016
14
Relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila pneumoniae and human herpesvirus 8 infection. ( 27382410 )
2016
15
Human herpesvirus 8 establishes a latent infection in prostates of Tobago men resulting in increased macrophage infiltration. ( 26848067 )
2016
16
Molecular typing of human herpesvirus 8 among HIV positive in comparison to HIV-negative individuals in Iran. ( 27463857 )
2016
17
High Prevalence of Human Herpesvirus 8 Infection in Diabetes Type 2 Patients and Detection of a New Virus Subtype. ( 27864801 )
2016
18
Is human herpesvirus 8 infection more common in men than in women? Systematic review and meta-analysis. ( 27062038 )
2016
19
HIV and human herpesvirus 8 co-infection across the globe: Systematic review and meta-analysis. ( 26175054 )
2016
20
No Evidence of Human Herpesvirus 8 among Iranian Patients Infected with HIV. ( 27517001 )
2016
21
High seroprevalence of human herpesvirus 8 and herpes simplex virus 2 infections in men who have sex with men in Shanghai, China. ( 27769110 )
2016
22
Development of Kaposi sarcoma and hemophagocytic lymphohistiocytosis associated with human herpesvirus 8 in a renal transplant recipient. ( 26842102 )
2016
23
Human herpesvirus 8 (HHV-8) detected by nested polymerase chain reaction (PCR) in HIV patients with or without Kaposi's sarcoma. An analytic cross-sectional study. ( 25885486 )
2015
24
Resveratrol induces cell death and inhibits human herpesvirus 8 replication in primary effusion lymphoma cells. ( 26549478 )
2015
25
Modulation of the Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1. ( 26512076 )
2015
26
The Role of Human Herpesvirus 8 in Diabetes Mellitus Type 2: State of the Art and a Medical Hypothesis. ( 26542602 )
2015
27
Identification of Human Herpesvirus 8 Sequences in Conjunctiva Intraepithelial Neoplasia and Squamous Cell Carcinoma of Ugandan Patients. ( 26509162 )
2015
28
Human herpesvirus 8 seroconversion in a population-based cohort of men in Tobago. ( 25612304 )
2015
29
Seroprevalence and Determinants of Kaposi Sarcoma-Associated Human Herpesvirus 8 in Indian HIV-Infected Males. ( 25375960 )
2014
30
Human herpesvirus 8 glycoprotein B binds the entry receptor DC-SIGN. ( 25018023 )
2014
31
Human Herpesvirus 8 Interleukin-6 Contributes to Primary Effusion Lymphoma Cell Viability via Suppression of Proapoptotic Cathepsin D, a Cointeraction Partner of Vitamin K Epoxide Reductase Complex Subunit 1 Variant 2. ( 24198402 )
2014
32
Human herpesvirus 8 viral interleukin-6 signaling through gp130 promotes virus replication in primary effusion lymphoma and endothelial cells. ( 25078695 )
2014
33
Development of whole-virus multiplex luminex-based serological assays for diagnosis of infections with kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 homologs in macaques. ( 23345584 )
2013
34
Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report. ( 24099147 )
2013
35
Kikuchi-Fujimoto lymphadenitis: role of parvovirus B-19, Epstein-Barr virus, human herpesvirus 6, and human herpesvirus 8. ( 22939574 )
2013
36
Primary effusion lymphoma-like lymphoma unrelated to human herpesvirus 8 with aggressive clinical course in patient receiving cyclosporine. ( 23775963 )
2013
37
High seroprevalence of human herpesvirus 8 infection in patients with systemic lupus erythematosus. ( 24283670 )
2013
38
Role of human herpesvirus 8 interleukin-6-activated gp130 signal transducer in primary effusion lymphoma cell growth and viability. ( 23903842 )
2013
39
Molecular epidemiology of human herpesvirus 8 variants in Kaposi's sarcoma from Iranian patients. ( 21963664 )
2012
40
Cisplatin disrupts the latency of human herpesvirus 8 and induces apoptosis in primary effusion lymphoma cells. ( 22480174 )
2012
41
Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties. ( 22016052 )
2012
42
Kaposi's Sarcoma and Human Herpesvirus 8 in Cuba: evidence of subtype B expansion. ( 22795824 )
2012
43
Human herpesvirus 8 viral interleukin-6 interacts with splice variant 2 of vitamin K epoxide reductase complex subunit 1. ( 22130532 )
2012
44
Human herpesvirus 8 is not detectable in lesions of large plaque parapsoriasis, and in early-stage sporadic, familial, and juvenile cases of mycosis fungoides. ( 21704421 )
2012
45
Detection of human herpesvirus 8 by quantitative polymerase chain reaction: development and standardisation of methods. ( 22963082 )
2012
46
Prevalence of human herpesvirus 8 DNA in peripheral blood mononuclear cells of acute and chronic leukemia patients in Taiwan. ( 21392127 )
2011
47
Seroprevalence of Human herpesvirus 8 (HHV-8) and incidence of Kaposi's sarcoma in Iran. ( 21527020 )
2011
48
Lysine residues of interferon regulatory factor 7 affect the replication and transcription activator-mediated lytic replication of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. ( 20844090 )
2011
49
Human herpesvirus 8 in corneal endotheliitis resulting in graft failure after penetrating keratoplasty refractory to allograft rejection therapy. ( 22159687 )
2011
50
Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the "Kaposi's sarcoma belt". ( 20143397 )
2010

Variations for Human Herpesvirus 8

Expression for Human Herpesvirus 8

Search GEO for disease gene expression data for Human Herpesvirus 8.

Pathways for Human Herpesvirus 8

Pathways related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 BCL2 BCL6 HLA-A HLA-B HLA-C IL6
2
Show member pathways
12.67 HLA-A HLA-B HLA-C IL6
3
Show member pathways
12.6 HLA-A HLA-B HLA-C IL6 NOP53
4
Show member pathways
12.43 BCL2 IL6 IL6R IL6ST
5
Show member pathways
12.34 BCL2 BCL6 HLA-A HLA-B HLA-C IL6
6 12.33 BCL2 HLA-A HLA-B HLA-C IL6 IL6R
7 12.25 HLA-A HLA-B HLA-C IL6
8
Show member pathways
12.15 IL6 IL6R IL6ST
9 12.1 BCL2 HLA-A HLA-B HLA-C
10 12.08 HLA-A HLA-B HLA-C IL6ST
11
Show member pathways
12 BCL2 IL6 IL6R IL6ST
12 11.99 HLA-A HLA-B HLA-C
13
Show member pathways
11.96 IL6 IL6R IL6ST
14 11.95 HLA-A HLA-B HLA-C
15 11.9 HLA-A HLA-B HLA-C
16
Show member pathways
11.88 HLA-A HLA-B HLA-C IL6
17 11.76 BCL2 IL6 IL6R
18
Show member pathways
11.74 IL6 IL6R IL6ST
19 11.73 IL6 IL6R IL6ST
20
Show member pathways
11.71 IL6 IL6R IL6ST
21
Show member pathways
11.66 IL6 IL6R IL6ST
22 11.61 BCL2 BCL6 IL6 IL6R
23
Show member pathways
11.46 IL6 IL6R IL6ST
24 11.28 BCL2 IL6 IL6R IL6ST
25
Show member pathways
11.23 IL6 IL6R IL6ST
26 11.1 IL6 IL6R IL6ST
27 10.88 BCL2 IL6
28 10.73 HLA-A HLA-B HLA-C

GO Terms for Human Herpesvirus 8

Cellular components related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.76 HLA-A HLA-B HLA-C IL6R
2 early endosome membrane GO:0031901 9.61 HLA-A HLA-B HLA-C
3 phagocytic vesicle membrane GO:0030670 9.58 HLA-A HLA-B HLA-C
4 recycling endosome membrane GO:0055038 9.54 HLA-A HLA-B HLA-C
5 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-A HLA-B HLA-C
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.33 HLA-A HLA-B HLA-C
7 ciliary neurotrophic factor receptor complex GO:0070110 9.26 IL6R IL6ST
8 MHC class I protein complex GO:0042612 9.13 HLA-A HLA-B HLA-C
9 interleukin-6 receptor complex GO:0005896 8.8 IL6 IL6R IL6ST

Biological processes related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

(show all 27)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 BCL2 IL6 IL6R IL6ST
2 negative regulation of apoptotic process GO:0043066 9.92 BCL2 BCL6 IL6 IL6ST
3 immune response GO:0006955 9.92 HLA-A HLA-B HLA-C IL6
4 immune system process GO:0002376 9.91 BCL6 HLA-A HLA-B HLA-C
5 viral process GO:0016032 9.89 HLA-A HLA-B HLA-C IL6ST
6 cytokine-mediated signaling pathway GO:0019221 9.77 IL6 IL6R IL6ST
7 regulation of apoptotic process GO:0042981 9.73 BCL2 BCL6 IL6
8 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.72 HLA-A HLA-B HLA-C
9 interferon-gamma-mediated signaling pathway GO:0060333 9.71 HLA-A HLA-B HLA-C
10 regulation of immune response GO:0050776 9.71 BCL6 HLA-A HLA-B HLA-C
11 response to glucocorticoid GO:0051384 9.7 BCL2 IL6 TRIM63
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.69 IL6 IL6R IL6ST
13 type I interferon signaling pathway GO:0060337 9.67 HLA-A HLA-B HLA-C
14 positive regulation of osteoblast differentiation GO:0045669 9.65 IL6 IL6R IL6ST
15 acute-phase response GO:0006953 9.63 IL6 IL6R
16 endocrine pancreas development GO:0031018 9.61 IL6 IL6R
17 positive regulation of chemokine production GO:0032722 9.58 IL6 IL6R
18 positive regulation of leukocyte chemotaxis GO:0002690 9.58 IL6 IL6R
19 positive regulation of acute inflammatory response GO:0002675 9.57 IL6 IL6ST
20 antigen processing and presentation GO:0019882 9.54 HLA-A HLA-B HLA-C
21 protection from natural killer cell mediated cytotoxicity GO:0042270 9.46 HLA-A HLA-B
22 response to cytokine GO:0034097 9.46 BCL2 IL6 IL6R IL6ST
23 ciliary neurotrophic factor-mediated signaling pathway GO:0070120 9.43 IL6R IL6ST
24 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.43 HLA-A HLA-B HLA-C
25 hepatic immune response GO:0002384 9.32 IL6 IL6R
26 interleukin-6-mediated signaling pathway GO:0070102 9.13 IL6 IL6R IL6ST
27 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.8 HLA-A HLA-B HLA-C

Molecular functions related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.67 HLA-A HLA-B HLA-C IL6
2 cytokine receptor activity GO:0004896 9.4 IL6R IL6ST
3 ciliary neurotrophic factor receptor activity GO:0004897 9.32 IL6R IL6ST
4 interleukin-6 receptor activity GO:0004915 9.26 IL6R IL6ST
5 interleukin-6 binding GO:0019981 9.16 IL6R IL6ST
6 peptide antigen binding GO:0042605 9.13 HLA-A HLA-B HLA-C
7 interleukin-6 receptor binding GO:0005138 8.8 IL6 IL6R IL6ST

Sources for Human Herpesvirus 8

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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