Aliases & Classifications for Human Herpesvirus 8

MalaCards integrated aliases for Human Herpesvirus 8:

Name: Human Herpesvirus 8 53
Human Herpesvirus 8, Susceptibility to 53 13
Hhv-8, Susceptibility to 53
Kaposi Sarcoma 69
Hhv8s 53
Hhv-8 53
Hhv8 44

Classifications:



External Ids:

OMIM 53 614836

Summaries for Human Herpesvirus 8

OMIM : 53 Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi sarcoma, primary effusion lymphoma, and some forms of multicentric Castleman disease (Pedergnana et al., 2012). See 148000 for general phenotypic information on these diseases, as well as information on HHV-8-associated pathogenesis. (614836)

MalaCards based summary : Human Herpesvirus 8, also known as human herpesvirus 8, susceptibility to, is related to kaposi sarcoma and primary effusion lymphoma, and has symptoms including pruritus and exanthema. An important gene associated with Human Herpesvirus 8 is HHV8S (Human Herpesvirus 8, Susceptibility To), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Bleomycin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and b cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Human Herpesvirus 8

Diseases related to Human Herpesvirus 8 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 kaposi sarcoma 33.1 HLA-A IL6 IL6ST
2 primary effusion lymphoma 30.5 BCL6 IL6
3 pityriasis rosea 30.0 HLA-A HLA-B HLA-C
4 paraneoplastic pemphigus 30.0 HLA-A HLA-B HLA-C
5 human immunodeficiency virus type 1 29.5 HLA-A HLA-B HLA-C IL6
6 castleman disease 29.5 IL6 IL6R KRT15
7 acquired immunodeficiency syndrome 29.3 BCL6 HLA-B IL6
8 multicentric castleman disease 29.0 BCL6 IL6 KRT15
9 sarcoma 10.5
10 phenytoin or carbamazepine toxicity 10.5 HLA-A HLA-B
11 postherpetic neuralgia 10.5 HLA-A HLA-B
12 lymphoma 10.5
13 atrial tachyarrhythmia with short pr interval 10.4 HLA-A HLA-B
14 pars planitis 10.4 HLA-A HLA-B
15 chronic pyelonephritis 10.4 HLA-A HLA-B
16 nontuberculous mycobacterial lung disease 10.4 HLA-A HLA-B
17 alveolar echinococcosis 10.4 HLA-A HLA-B
18 histoplasmosis 10.4 HLA-A HLA-B
19 birdshot chorioretinopathy 10.3 HLA-A HLA-C
20 pure red-cell aplasia 10.3 HLA-A HLA-B
21 glaucomatocyclitic crisis 10.3 HLA-A HLA-B HLA-C
22 idiopathic bronchiectasis 10.3 HLA-A HLA-B HLA-C
23 intermediate uveitis 10.3 HLA-B IL6
24 geographic tongue 10.3 HLA-A HLA-B HLA-C
25 severe cutaneous adverse reaction 10.2 HLA-A HLA-B HLA-C
26 anterior uveitis 10.2 HLA-A HLA-B IL6
27 aphthous stomatitis 10.2 HLA-A HLA-B IL6
28 takayasu arteritis 10.2 HLA-A HLA-B IL6
29 extramedullary plasmacytoma 10.2 BCL2 IL6
30 spondylitis 10.2 HLA-B HLA-C IL6
31 separation anxiety disorder 10.2 HLA-A HLA-B
32 endotheliitis 10.1
33 hematopoietic stem cell transplantation 10.0 HLA-A HLA-B HLA-C IL6
34 spondyloarthropathy 10.0 HLA-A HLA-B HLA-C IL6
35 graft-versus-host disease 10.0 HLA-A HLA-B HLA-C IL6
36 behcet syndrome 10.0 HLA-A HLA-B HLA-C IL6
37 aplastic anemia 10.0 HLA-A HLA-B IL6
38 pulmonary hypertension 10.0
39 leukemia 10.0
40 joint disorders 9.9 IL6 IL6R
41 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 9.9 BCL2 BCL6
42 mycosis fungoides 9.9
43 autoimmune lymphoproliferative syndrome, type v 9.9
44 anaplastic large cell lymphoma 9.9
45 diabetes mellitus 9.9
46 dementia 9.9
47 poems syndrome 9.9
48 prostatitis 9.9
49 pneumonia 9.9
50 parapsoriasis 9.9

Graphical network of the top 20 diseases related to Human Herpesvirus 8:



Diseases related to Human Herpesvirus 8

Symptoms & Phenotypes for Human Herpesvirus 8

Clinical features from OMIM:

614836

UMLS symptoms related to Human Herpesvirus 8:


pruritus, exanthema

GenomeRNAi Phenotypes related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

25 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.75 HLA-B HLA-C HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.75 HLA-C HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.75 HLA-B HLA-C HLA-A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.75 HLA-C IL6R
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.75 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.75 HLA-B HLA-C HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.75 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.75 HLA-C HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.75 HLA-C HLA-A IL6R HLA-B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.75 HLA-C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.75 HLA-C HLA-A HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-37 10.75 IL6R
13 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.75 HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.75 HLA-B HLA-C HLA-A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.75 HLA-B HLA-C HLA-A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.75 HLA-C

MGI Mouse Phenotypes related to Human Herpesvirus 8:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 BCL2 IL6 IL6R IL6ST NOP53

Drugs & Therapeutics for Human Herpesvirus 8

Drugs for Human Herpesvirus 8 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 188)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 11056-06-7 5360373
2
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
3
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
4
Efavirenz Approved, Investigational Phase 4,Phase 3 154598-52-4 64139
5
Ritonavir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 155213-67-5 392622
6
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3 134678-17-4 60825
7
Nevirapine Approved Phase 4,Phase 3 129618-40-2 4463
8
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
9
Emtricitabine Approved, Investigational Phase 4,Phase 3 143491-57-0 60877
10
Lopinavir Approved Phase 4,Phase 2,Phase 3 192725-17-0 92727
11
Ganciclovir Approved, Investigational Phase 4,Phase 2 82410-32-0 3454
12
Valganciclovir Approved, Investigational Phase 4,Phase 2 175865-60-8 64147
13
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
14 Anti-HIV Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
15 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
16 Anti-Retroviral Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
17 Antiviral Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
18 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
19
protease inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
20 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1
21 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 3
22 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
23 Reverse Transcriptase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
24 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3
25 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
26 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3
27 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4,Phase 3
28
Tenofovir Phase 4,Phase 3 147127-20-6 464205
29 Ganciclovir triphosphate Phase 4,Phase 2
30
Meloxicam Approved, Vet_approved Phase 3 71125-38-7 54677470 5281106
31
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
32
Abacavir Approved, Investigational Phase 2, Phase 3 136470-78-5 441300 65140
33
Zidovudine Approved Phase 2, Phase 3, Phase 1 30516-87-1 35370
34
Daunorubicin Approved Phase 3,Phase 1 20830-81-3 30323
35
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
36
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
37 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
38 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
39 Antimitotic Agents Phase 3,Phase 2,Phase 1
40 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
41 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
42 Analgesics Phase 3,Phase 2,Phase 1
43 Analgesics, Non-Narcotic Phase 3,Phase 2,Phase 1
44 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
45 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 1,Phase 2
46 Antirheumatic Agents Phase 3,Phase 2,Phase 1
47 Cyclooxygenase 2 Inhibitors Phase 3
48 Cyclooxygenase Inhibitors Phase 3
49 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
50 Albumin-Bound Paclitaxel Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 164)

# Name Status NCT ID Phase Drugs
1 HIV/AIDS Kaposis Sarcoma: Comparison of Response to HAART vs HAART Plus CXT Completed NCT00380770 Phase 4 Generic HAART Triomune : d4T, 3TC, NVP;Generic HAART Triomune : d4T, 3TC, NVP and chemotherapy ABV
2 Anti-Retrovirals for Kaposi's Sarcoma Completed NCT00444379 Phase 4 Lopinavir/ritonavir plus Emtricitabine/Tenofovir versus Efavirenz plus Emtricitabine/Tenofovir
3 Organ Transplant Infection Prevention and Detection Project Completed NCT00177801 Phase 4
4 Valganciclovir to Treat HHV-8 Associated Multicentric Castleman's Disease Withdrawn NCT00361933 Phase 4 Valganciclovir
5 A Comparison of DOX-SL Versus Adriamycin Plus Bleomycin Plus Vincristine in the Treatment of Severe AIDS-Related Kaposi's Sarcoma Unknown status NCT00002318 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
6 TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial Unknown status NCT02060006 Phase 3 Meloxicam 7.5mg daily for 8 weeks
7 A Pilot Study Of the Effects of Highly Active Antiretroviral Therapy on Kaposi's Sarcoma in Zimbabwe Completed NCT00834457 Phase 2, Phase 3 abacavir/3TC/zidovudine;abacavir /3TC plus ritonavir boosted lopinavir
8 Paclitaxel Compared With Doxorubicin in Treating Patients With Advanced AIDS-Related Kaposi's Sarcoma Completed NCT00003350 Phase 3 paclitaxel;pegylated liposomal doxorubicin hydrochloride
9 Doxorubicin in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00002985 Phase 3 daunorubicin hydrochloride;pegylated liposomal doxorubicin hydrochloride
10 A Study of DOX-SL in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00002319 Phase 3 Doxorubicin hydrochloride (liposomal)
11 Use of Stealth Liposomal Doxorubicin HCl ( DOX-SL ) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma. Completed NCT00002147 Phase 3 Doxorubicin hydrochloride (liposomal)
12 Safety and Effectiveness of an Experimental Drug, IM862, in Treating Kaposi's Sarcoma in AIDS Patients Completed NCT00002445 Phase 3 IM862
13 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00002105 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate
14 A Study of AZT in HIV-Infected Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00000994 Phase 3 Zidovudine
15 A Randomized Phase III Clinical Trial of Daunoxome Versus Combination Chemotherapy With Adriamycin/Bleomycin/Vincristine (ABV) in the Treatment of HIV-Associated Kaposi's Sarcoma. Completed NCT00002093 Phase 3 Daunorubicin (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
16 Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone Completed NCT01924286 Phase 3 Prednisone;Placebo
17 Three Chemo Regimens as an Adjunct to ART for Treatment of Advanced AIDS-KS Recruiting NCT01435018 Phase 3 Coformulated EFV/FTC/TDF;Etoposide;Bleomycin and Vincristine (BV);Paclitaxel (PTX)
18 Antiretroviral Therapy (ART) Alone or With Delayed Chemo Versus ART With Immediate Chemo for Limited AIDS-related Kaposi's Sarcoma Active, not recruiting NCT01352117 Phase 3 efavirenz/emtricitabine/tenofovir disoproxil fumarate;etoposide
19 Antiviral Therapy in Treating Patients With Slowly Progressing HIV-Related Kaposi's Sarcoma Unknown status NCT00003419 Phase 2
20 Sorafenib and Paclitaxel in Treating Patients With Metastatic Breast Cancer Unknown status NCT00622466 Phase 2 paclitaxel;sorafenib tosylate
21 Suppression of Oral HHV8 Shedding With Valganciclovir Completed NCT00194467 Phase 2 valganciclovir;placebo
22 Treatment With Indinavir and Chemotherapy for Advanced Classical Kaposi's Sarcoma Completed NCT01067690 Phase 2 Indinavir in association with Vinblastina +/- Bleomicina
23 Intralesional Bevacizumab for Treating AIDS-associated Kaposi´s Sarcoma of the Larynx, Pharynx and Oral Cavity Completed NCT01296815 Phase 2 Bevacizumab
24 Treatment of Classical Non-HIV-Related Kaposi's Sarcoma With the Antiviral Drug Indinavir Completed NCT00362310 Phase 2 indinavir
25 Halofuginone Hydrobromide in Treating Patients With HIV-Related Kaposi's Sarcoma Completed NCT00064142 Phase 2 halofuginone hydrobromide
26 Interleukin-12 in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00019188 Phase 1, Phase 2 interleukin-12
27 Bevacizumab to Treat Kaposi's Sarcoma in HIV-Positive and HIV-Negative Patients Completed NCT00055237 Phase 2
28 Lenalidomide in Treating Patients With AIDS-Associated Kaposi's Sarcoma Completed NCT01057121 Phase 1, Phase 2 Lenalidomide
29 Nicotine Skin Patch in Treating Patients With Kaposi's Sarcoma Completed NCT00295984 Phase 2 nicotine
30 BMS-275291 in Treating Patients With HIV-Related Kaposi's Sarcoma Completed NCT00024024 Phase 1, Phase 2 rebimastat
31 Imatinib Mesylate in Treating Patients With HIV-Related Kaposi's Sarcoma Completed NCT00090987 Phase 2 imatinib mesylate
32 SU5416 in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00005042 Phase 2 semaxanib
33 A Study to Investigate ALDOXORUBICIN in HIV-infected Subjects With Kaposi's Sarcoma Completed NCT02029430 Phase 2 aldoxorubicin
34 Evaluation of Tc 99m Tilmanocept Localization in Primary Cutaneous Kaposi's Sarcoma and Lymphatic Drainage by SPECT/CT Completed NCT02201420 Phase 2 Tc 99m tilmanocept
35 Antiviral Therapy in Treating Patients With Kaposi's Sarcoma With or Without HIV Infection Completed NCT00019240 Phase 2 cidofovir
36 Thalidomide in Treating Patients With HIV-Associated Kaposi's Sarcoma Completed NCT00019123 Phase 2 thalidomide
37 Paclitaxel in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00003008 Phase 2 indinavir sulfate;nelfinavir mesylate;paclitaxel;ritonavir;saquinavir mesylate
38 Liposomal Doxorubicin and Interleukin-12 in Treating Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00020449 Phase 2 paclitaxel;pegylated liposomal doxorubicin hydrochloride
39 A Study of ALRT1057 in Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00002188 Phase 2 Alitretinoin
40 A Pilot Study of OPC-8212 (Vesnarinone) in Persons With AIDS-Related Kaposi's Sarcoma Completed NCT00002131 Phase 2 Vesnarinone
41 The Safety and Effectiveness of Ritonavir in the Treatment of HIV-Related Kaposi's Sarcoma Completed NCT00002366 Phase 2 Ritonavir
42 A Study of Targretin Capsules in Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00002212 Phase 2 Bexarotene
43 Phase II Study of Intravenous Novantrone(R) in the Treatment of AIDS Related Kaposi's Sarcoma Completed NCT00002259 Phase 2 Mitoxantrone hydrochloride
44 The Safety and Effectiveness of Interferon Alfa-2B Plus Didanosine in Patients With Kaposi's Sarcoma Completed NCT00001114 Phase 2 Interferon alfa-2b;Didanosine
45 SU5416 in Patients With AIDS-Related Kaposi's Sarcoma Who Have Not Responded to Treatment Completed NCT00005931 Phase 2 SU5416
46 Photodynamic Therapy Clinical Trial For Cutaneous AIDS-Related Kaposi's Sarcoma Study Summary. Completed NCT00002167 Phase 2 Tin ethyl etiopurpurin
47 A Study of Doxorubicin in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00000996 Phase 2 Doxorubicin hydrochloride
48 A Study of Ro 24-7429 in Patients With HIV-Related Kaposi's Sarcoma Completed NCT00002314 Phase 2 Ro 24-7429
49 Paclitaxel in Advanced Refractory Kaposi's Sarcoma (AIDS-KS): A Phase II Trial of Paclitaxel From Baker Norton Pharmaceuticals Completed NCT00002189 Phase 2 Paclitaxel
50 Phase II Evaluation of Low-Dose Oral Etoposide for the Treatment of Relapsed or Progressed AIDS-Related Kaposi's Sarcoma After Systemic Chemotherapy Completed NCT00000807 Phase 2 Etoposide

Search NIH Clinical Center for Human Herpesvirus 8

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Human Herpesvirus 8

Anatomical Context for Human Herpesvirus 8

MalaCards organs/tissues related to Human Herpesvirus 8:

38
Skin, Testes, B Cells, Liver, T Cells, Kidney, Endothelial

Publications for Human Herpesvirus 8

Articles related to Human Herpesvirus 8:

(show top 50) (show all 152)
# Title Authors Year
1
Global epidemiology of human herpesvirus 8 in men who have sex with men: A systematic review and meta-analysis. ( 28975631 )
2018
2
Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase. ( 29343584 )
2018
3
Association of Household Food- and Drink-Sharing Practices With Human Herpesvirus 8 Seroconversion in a Cohort of Zambian Children. ( 28961804 )
2017
4
Successful Treatment of Kaposi Sarcoma-Associated Herpesvirus Inflammatory Cytokine Syndrome After Kidney-Liver Transplant: Correlations With the Human Herpesvirus 8 miRNome and Specific T Cell Response. ( 28489271 )
2017
5
Correction for Cousins and Nicholas, "Role of Human Herpesvirus 8 Interleukin-6-Activated gp130 Signal Transducer in Primary Effusion Lymphoma Cell Growth and Viability". ( 29191994 )
2017
6
Human herpesvirus 8 infection contributes to a T helper 2 immune response in men from Tobago with prostate cancer. ( 27734534 )
2017
7
Presence of human herpesvirus 8 (HHV-8) DNA sequences in patients with lymphoproliferative diseases and chronic blood disorders. ( 28916317 )
2017
8
Human Herpesvirus 8 in Perinatally HIV-infected Children with Interstitial Lung Disease. ( 29165615 )
2017
9
Elevated Serum PSA is Associated With Human Herpesvirus 8 Infection and Increased Circulating Cytokine Levels in Men From Tobago. ( 28117495 )
2017
10
De Novo Human Herpesvirus 8 Tumors Induced by Rituximab in Autoimmune or Inflammatory Systemic Diseases. ( 28719723 )
2017
11
High Seroprevalence of Human Herpesvirus 8 Infection in HIV-positive Homosexual Men in Jiangsu Province, China. ( 28606034 )
2017
12
Prospective study of human herpesvirus 8 oral shedding, viremia, and serological status among human immunodeficiency virus seropositive and seronegative individuals in Sao Paulo, Brazil. ( 29081916 )
2017
13
Diversity of human herpesvirus 8 genotypes in patients with AIDS and non-AIDS associated Kaposi's sarcoma, Castleman's disease and primary effusion lymphoma in Argentina. ( 28617968 )
2017
14
Human Herpesvirus 8 Interleukin-6 Interacts with Calnexin Cycle Components and Promotes Protein Folding. ( 28878084 )
2017
15
High Prevalence of Distinct Human Herpesvirus 8 Contributes to the High Incidence of Non-acquired Immune Deficiency Syndrome-Associated Kaposi's Sarcoma in Isolated Japanese Islands. ( 28968717 )
2017
16
Regulatory T Cell Effect on CD8(+) T Cell Responses to Human Herpesvirus 8 Infection and Development of Kaposi's Sarcoma. ( 28121161 )
2017
17
Cross-sectional and longitudinal investigation of human herpesvirus 8 seroprevalence in HIV-1-infected individuals in Osaka, Japan. ( 28131739 )
2017
18
Human Herpesvirus 8 Infects and Replicates in Langerhans Cells and Interstitial Dermal Dendritic Cells and Impairs Their Function. ( 28768873 )
2017
19
Correction for Cousins et al., "Human Herpesvirus 8 Viral Interleukin-6 Signaling through gp130 Promotes Virus Replication in Primary Effusion Lymphoma and Endothelial Cells". ( 29138334 )
2017
20
Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells. ( 29267216 )
2017
21
Seroprevalence of Human Herpesvirus 8 and its Impact on the Hemoglobin Level in Patients of End Stage of Renal Diseases. ( 28876458 )
2017
22
Effect of electrochemotherapy on human herpesvirus 8 kinetics in classic Kaposi sarcoma. ( 28649271 )
2017
23
No Evidence of Human Herpesvirus 8 among Iranian Patients Infected with HIV. ( 27517001 )
2016
24
Development of Kaposi sarcoma and hemophagocytic lymphohistiocytosis associated with human herpesvirus 8 in a renal transplant recipient. ( 26842102 )
2016
25
Is human herpesvirus 8 infection more common in men than in women? Systematic review and meta-analysis. ( 27062038 )
2016
26
Molecular typing of human herpesvirus 8 among HIV positive in comparison to HIV-negative individuals in Iran. ( 27463857 )
2016
27
Human herpesvirus 8 establishes a latent infection in prostates of Tobago men resulting in increased macrophage infiltration. ( 26848067 )
2016
28
Prevalence of Human herpesvirus 8 infection in people living with HIV/AIDS in Pernambuco, Brazil. ( 27089548 )
2016
29
High Prevalence of Human Herpesvirus 8 Infection in Diabetes Type 2 Patients and Detection of a New Virus Subtype. ( 27864801 )
2016
30
HIV and human herpesvirus 8 co-infection across the globe: Systematic review and meta-analysis. ( 26175054 )
2016
31
Relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila pneumoniae and human herpesvirus 8 infection. ( 27382410 )
2016
32
High seroprevalence of human herpesvirus 8 and herpes simplex virus 2 infections in men who have sex with men in Shanghai, China. ( 27769110 )
2016
33
Human herpesvirus 8 (HHV-8) detected by nested polymerase chain reaction (PCR) in HIV patients with or without Kaposi's sarcoma. An analytic cross-sectional study. ( 25885486 )
2015
34
The Role of Human Herpesvirus 8 in Diabetes Mellitus Type 2: State of the Art and a Medical Hypothesis. ( 26542602 )
2015
35
Modulation of the Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1. ( 26512076 )
2015
36
Resveratrol induces cell death and inhibits human herpesvirus 8 replication in primary effusion lymphoma cells. ( 26549478 )
2015
37
Human herpesvirus 8 seroconversion in a population-based cohort of men in Tobago. ( 25612304 )
2015
38
Identification of Human Herpesvirus 8 Sequences in Conjunctiva Intraepithelial Neoplasia and Squamous Cell Carcinoma of Ugandan Patients. ( 26509162 )
2015
39
Human Herpesvirus 8 Interleukin-6 Contributes to Primary Effusion Lymphoma Cell Viability via Suppression of Proapoptotic Cathepsin D, a Cointeraction Partner of Vitamin K Epoxide Reductase Complex Subunit 1 Variant 2. ( 24198402 )
2014
40
Human herpesvirus 8 viral interleukin-6 signaling through gp130 promotes virus replication in primary effusion lymphoma and endothelial cells. ( 25078695 )
2014
41
Human herpesvirus 8 glycoprotein B binds the entry receptor DC-SIGN. ( 25018023 )
2014
42
Seroprevalence and Determinants of Kaposi Sarcoma-Associated Human Herpesvirus 8 in Indian HIV-Infected Males. ( 25375960 )
2014
43
Primary effusion lymphoma-like lymphoma unrelated to human herpesvirus 8 with aggressive clinical course in patient receiving cyclosporine. ( 23775963 )
2013
44
Role of human herpesvirus 8 interleukin-6-activated gp130 signal transducer in primary effusion lymphoma cell growth and viability. ( 23903842 )
2013
45
Development of whole-virus multiplex luminex-based serological assays for diagnosis of infections with kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 homologs in macaques. ( 23345584 )
2013
46
High seroprevalence of human herpesvirus 8 infection in patients with systemic lupus erythematosus. ( 24283670 )
2013
47
Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report. ( 24099147 )
2013
48
Kikuchi-Fujimoto lymphadenitis: role of parvovirus B-19, Epstein-Barr virus, human herpesvirus 6, and human herpesvirus 8. ( 22939574 )
2013
49
Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties. ( 22016052 )
2012
50
Kaposi's Sarcoma and Human Herpesvirus 8 in Cuba: evidence of subtype B expansion. ( 22795824 )
2012

Variations for Human Herpesvirus 8

Expression for Human Herpesvirus 8

Search GEO for disease gene expression data for Human Herpesvirus 8.

Pathways for Human Herpesvirus 8

Pathways related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 BCL2 BCL6 HLA-A HLA-B HLA-C IL6
2
Show member pathways
12.68 HLA-A HLA-B HLA-C IL6
3 12.67 BCL2 IL6 IL6R IL6ST
4
Show member pathways
12.67 BCL2 HLA-A HLA-B HLA-C IL6 IL6R
5
Show member pathways
12.67 BCL2 BCL6 HLA-A HLA-B HLA-C IL6
6
Show member pathways
12.63 HLA-A HLA-B HLA-C IL6 NOP53
7
Show member pathways
12.44 BCL2 IL6 IL6R IL6ST
8 12.27 HLA-A HLA-B HLA-C IL6
9
Show member pathways
12.18 BCL2 IL6 IL6R IL6ST
10
Show member pathways
12.16 IL6 IL6R IL6ST
11 12.13 BCL2 HLA-A HLA-B HLA-C
12 12.11 HLA-A HLA-B HLA-C IL6ST
13 11.99 HLA-A HLA-B HLA-C
14
Show member pathways
11.97 IL6 IL6R IL6ST
15 11.96 HLA-A HLA-B HLA-C
16 11.96 HLA-A HLA-B HLA-C IL6
17 11.91 HLA-A HLA-B HLA-C
18
Show member pathways
11.91 HLA-A HLA-B HLA-C IL6
19 11.77 BCL2 IL6 IL6R
20
Show member pathways
11.73 IL6 IL6R IL6ST
21
Show member pathways
11.71 IL6 IL6R IL6ST
22 11.7 IL6 IL6R IL6ST
23
Show member pathways
11.68 IL6 IL6R IL6ST
24
Show member pathways
11.62 BCL2 HLA-A HLA-B HLA-C IL6 IL6ST
25 11.61 BCL2 BCL6 IL6 IL6R
26
Show member pathways
11.49 IL6 IL6R IL6ST
27 11.48 BCL2 IL6 IL6R IL6ST
28
Show member pathways
11.28 IL6 IL6R IL6ST
29 11.13 IL6 IL6R IL6ST
30 10.9 HLA-A HLA-B HLA-C
31 10.89 BCL2 IL6

GO Terms for Human Herpesvirus 8

Cellular components related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome membrane GO:0031901 9.61 HLA-A HLA-B HLA-C
2 phagocytic vesicle membrane GO:0030670 9.58 HLA-A HLA-B HLA-C
3 recycling endosome membrane GO:0055038 9.54 HLA-A HLA-B HLA-C
4 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-A HLA-B HLA-C
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.33 HLA-A HLA-B HLA-C
6 ciliary neurotrophic factor receptor complex GO:0070110 9.26 IL6R IL6ST
7 MHC class I protein complex GO:0042612 9.13 HLA-A HLA-B HLA-C
8 interleukin-6 receptor complex GO:0005896 8.8 IL6 IL6R IL6ST

Biological processes related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.92 BCL2 BCL6 IL6 IL6ST
2 positive regulation of cell proliferation GO:0008284 9.91 BCL2 IL6 IL6R IL6ST
3 immune system process GO:0002376 9.91 BCL6 HLA-A HLA-B HLA-C
4 immune response GO:0006955 9.9 HLA-A HLA-B HLA-C IL6
5 viral process GO:0016032 9.88 HLA-A HLA-B HLA-C IL6ST
6 cytokine-mediated signaling pathway GO:0019221 9.76 IL6 IL6R IL6ST
7 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.71 HLA-A HLA-B HLA-C
8 interferon-gamma-mediated signaling pathway GO:0060333 9.7 HLA-A HLA-B HLA-C
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.69 IL6 IL6R IL6ST
10 type I interferon signaling pathway GO:0060337 9.67 HLA-A HLA-B HLA-C
11 regulation of immune response GO:0050776 9.67 BCL6 HLA-A HLA-B HLA-C
12 response to cytokine GO:0034097 9.65 BCL2 IL6R IL6ST
13 positive regulation of osteoblast differentiation GO:0045669 9.63 IL6 IL6R IL6ST
14 acute-phase response GO:0006953 9.62 IL6 IL6R
15 endocrine pancreas development GO:0031018 9.59 IL6 IL6R
16 positive regulation of chemokine production GO:0032722 9.57 IL6 IL6R
17 positive regulation of leukocyte chemotaxis GO:0002690 9.56 IL6 IL6R
18 positive regulation of acute inflammatory response GO:0002675 9.55 IL6 IL6ST
19 antigen processing and presentation GO:0019882 9.5 HLA-A HLA-B HLA-C
20 protection from natural killer cell mediated cytotoxicity GO:0042270 9.43 HLA-A HLA-B
21 ciliary neurotrophic factor-mediated signaling pathway GO:0070120 9.4 IL6R IL6ST
22 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.33 HLA-A HLA-B HLA-C
23 hepatic immune response GO:0002384 9.26 IL6 IL6R
24 interleukin-6-mediated signaling pathway GO:0070102 9.13 IL6 IL6R IL6ST
25 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.8 HLA-A HLA-B HLA-C

Molecular functions related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 9.37 IL6R IL6ST
2 ciliary neurotrophic factor receptor activity GO:0004897 9.32 IL6R IL6ST
3 interleukin-6 binding GO:0019981 9.26 IL6R IL6ST
4 interleukin-6 receptor activity GO:0004915 9.16 IL6R IL6ST
5 peptide antigen binding GO:0042605 9.13 HLA-A HLA-B HLA-C
6 interleukin-6 receptor binding GO:0005138 8.8 IL6 IL6R IL6ST

Sources for Human Herpesvirus 8

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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