Human Immunodeficiency Virus Infectious Disease malady

Disease Ontology: A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has material basis in human immunodeficiency virus 1 or has material basis in human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. the virus infects helper t cells (cd4+ t cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. the infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.⁶

MalaCards: Human Immunodeficiency Virus Infectious Disease, also known as hiv infection, is related to hepatitis and tuberculosis, and has symptoms including diarrhea, fatigue and fever. An important gene associated with Human Immunodeficiency Virus Infectious Disease is IGHV4-39 (immunoglobulin heavy variable 4-39), and among its related pathways are Antigen processing and presentation and Primary immunodeficiency. The compounds cyclophosphamide and ivig have been mentioned in the context of this disorder. Affiliated tissues include breast and t cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

human immunodeficiency virus infectious disease 6 8 hiv infection 6

Diseases related to human immunodeficiency virus infectious disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 860)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	34.6	FASLG, FAS, IFNA1, ALB, HLA-A, TAT
2	tuberculosis	33.5	CD209, IL10, IL1B, IL4, CCL2, IFNG
3	kaposi's sarcoma	31.0	CD14, CD34, IL6, CCR3, IFNA1, TNFRSF8
4	mycobacterium tuberculosis	30.9	CD209, CCL2, TNF
5	hepatitis b	30.7	IL10, IL2RA, CCR5, IFNA1, IFNG, ALB
6	hepatitis c	30.7	CD28, CD69, CD40LG, IL10, IL2, IL4
7	lipodystrophy	30.7	CD4, INS, INSR, IL6, FAS, CCL2
8	pulmonary tuberculosis	30.4	CD14, IL10, IL2, IL2RA, IL4, CCL4
9	syphilis	29.7	B2M, CD209, CD79A, CD4, CD40LG, CCR5
10	hiv-1, resistance to	29.0	CD4, IL10, CCR2, CCL2, CCR5, HLA-A
11	visceral leishmaniasis	28.8	IL10, IL4, IFNG
12	immunodeficiency	28.8	SELL, CD209, CD28, CD79A, CD69, CD4
13	castleman's disease	28.6	B2M, IL10, IL6, IL7, CCL4, IFNA1
14	cardiac tamponade	28.6	CD79A, CD40LG, F8, ADA
15	multiple sclerosis	28.6	CD14, IL1B, IL2RA, IL7R, CCR5, IFNG
16	hodgkin's lymphoma	28.3	CD28, CD68, IL2, IL2RA, IL7, HLA-A
17	malaria	28.2	CD40LG, IL10, IL4, IFNG, TNF
18	aids dementia complex	28.1	NCOA6, B2M, CD27, CD4, IVD, IL10
19	hypergammaglobulinemia	28.0	CD79A, CD27, CD4, CD40LG, IL10, IL2RA
20	retinol binding protein	28.0	B2M, INS, INSR, CCL2, ALB, TNF
21	hypereosinophilic syndrome	28.0	CD69, IL2, IL2RA, IFNA1, CSF2
22	hyper-ige syndrome	27.9	SELL, IL10, IL4, IL6, IFNG, CSF2
23	antiphospholipid syndrome	27.5	CD79A, CD40LG, ENPEP, F8, TNF, CXCL12
24	pleural tuberculosis	27.4	IL4, IFNG, TNF, ADA
25	arthritis	27.1	SELL, IL1B, IL6, TNF
26	burkitt's lymphoma	27.1	CD27, CD40LG, CD38, IL4, IL7, FASLG
27	insulin resistance	27.1	SELL, CD14, CD40LG, INS, INSR, IL10
28	proteinuria	27.0	SELL, B2M, CD79A, CD40LG, INS, IL2RA
29	tuberculous meningitis	27.0	IL10, IL1B, CCL3, IFNG, TNF, ADA
30	hemophilia	27.0	CD4, CD40LG, IL10, IL1B, IL4, IL6
31	liver cirrhosis	27.0	CD14, CD34, INSR, IFNA1, ALB, HLA-A
32	histoplasmosis	26.7	CD79A, CD4, CD40LG, IFNG, HLA-A, HLA-B
33	neurologic diseases	26.6	B2M, IL15, IL1B, IL2, IL2RA, IL6
34	primary effusion lymphoma	26.5	SELL, IL10, IL6, IFNA1, HLA-B, PTPRC
35	mycobacterium avium complex disease	26.5	CD4, IL10, IL6, IFNG, TNF
36	bacterial vaginosis	26.5	IL10, IL1B, IL4, IL6, TNF, PRF1
37	t-cell leukemia	26.3	CD209, CD28, CD4, IL2, IL2RA, FASLG
38	periodontitis	26.3	CD209, CD14, IL10, IL1B, IL6, CCL2
39	glucose intolerance	26.1	INS, INSR, IL6, CCL2, IFNA1, ALB
40	cryptococcosis	26.1	SELL, CD4, CD40LG, IL10, IL6, IFNG
41	schizophrenia	26.1	KALRN, IL1B, IL2, IL4, CCR5, TNF
42	diabetic ketoacidosis	26.0	INS, IL10, IL6, ALB, CSF3
43	hypertriglyceridemia	25.3	INS, INSR, IL1B, IL6, FAS, IFNA1
44	candidiasis	25.3	B2M, CD79A, CD4, CD40LG, INS, IL10
45	fatty liver disease	25.2	CD14, CD40LG, INS, INSR, IL6, FAS
46	atopy	25.1	CD28, CD79A, CD14, IL10, IL15, IL1B
47	herpes zoster	25.1	REV3L, CD79A, CD8A, CD4, IL10, IL4
48	diphtheria	24.8	CD79A, CD4, CD40LG, IL2, IL2RA, CCL3
49	aldosteronism	24.7	B2M, INS, INSR, IL1B, IL6, CCL2
50	cervical intraepithelial neoplasia	24.5	KIR2DL2, B2M, IL2, IL2RA, IL6, FASLG

Symptoms: diarrhea, fatigue, fever, vaginal yeast infection, headache, mouth sores, muscle aches, sore throat, swollen lymph gl.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to human immunodeficiency virus infectious disease:

²²

MGI Mouse Phenotypes related to human immunodeficiency virus infectious disease:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.7	ADA, PTPRC, CCR2, INSR, CD14, SELL
2	endocrine/exocrine gland phenotype	MP:0005379	9.5	CARTPT, IFNG, FASLG, IL2, CD40LG, SELL
3	renal/urinary system phenotype	MP:0005367	9.3	EHD3, CXCR4, CR2, DDC, PTPRC, INSR
4	hematopoietic system phenotype	MP:0005397	9.2	REV3L, CD28, CD27, CSF2, CSF3, POLD1
5	no phenotypic analysis	MP:0003012	9.0	CYP3A43, HLA-C, CCR5, CCR2, INS, CD4
6	integument phenotype	MP:0010771	8.7	IFNG, CSF2, CSF3, POLD1, POLE, FAS
7	nervous system phenotype	MP:0003631	8.4	CCL3, CCR7, HLA-C, PTPRC, DDC, PRF1
8	skeleton phenotype	MP:0005390	8.2	PTPRC, NFKB1, CXCR4, CSF2, ADA, CARTPT
9	liver/biliary system phenotype	MP:0005370	8.2	EPO, ADA, PTPRC, IFNG, CCR5, CCR2
10	digestive/alimentary phenotype	MP:0005381	8.1	CCL3, CCR7, IFNG, PTPRC, ACTG1, CXCR4
11	growth/size phenotype	MP:0005378	7.5	CARTPT, PTPRC, NFKB1, ACTG1, CSF2, EHD3
12	immune system phenotype	MP:0005387	7.3	REV3L, CARTPT, HLA-C, TNF, TNFRSF8, PTPRC
13	mortality/aging	MP:0010768	7.2	F8, EXTL3, HLA-C, DDC, CR2, ACTG1
14	reproductive system phenotype	MP:0005389	7.0	CCR5, IFNG, F8, IDO1, TNF, CSF2
15	normal phenotype	MP:0002873	6.7	ALB, PTPRC, NFKB1, PRF1, POLA1, EHD3
16	tumorigenesis	MP:0002006	6.4	CCL2, CCR5, IFNG, TNF, PTPRC, CYP1B1
17	homeostasis/metabolism phenotype	MP:0005376	5.3	PTPRC, EXTL3, CARTPT, ALB, IDO1, F8
18	cardiovascular system phenotype	MP:0005385	4.9	CCR2, CCL2, CCR5, IFNG, TNF, DDC
19	cellular phenotype	MP:0005384	2.7	CD28, IL2, IL2RA, IL4, IL6, IL7

Genes related to human immunodeficiency virus infectious disease according to GeneCards:

(show top 50)    (show all 99)

id	Symbol	Description	Score	GeneCards Section Context
1	IGHV4-39	immunoglobulin heavy variable 4-39	11.0
2	ACOT1	acyl-CoA thioesterase 1	11.0
3	ERAS	ES cell expressed Ras	11.0
4	CYP2D7P1	cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 1	11.0
5	CCL3L1	chemokine (C-C motif) ligand 3-like 1	11.0
6	IVD	isovaleryl-CoA dehydrogenase	11.0
7	CARTPT	CART prepropeptide	11.0
8	PARP9	poly (ADP-ribose) polymerase family, member 9	11.0
9	POLE3	polymerase (DNA directed), epsilon 3, accessory subunit	11.0
10	CD68	CD68 molecule	11.0
11	KIR2DL2	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2	11.0
12	CCL13	chemokine (C-C motif) ligand 13	11.0
13	EHD3	EH-domain containing 3	11.0
14	CYP4X1	cytochrome P450, family 4, subfamily X, polypeptide 1	11.0	Disorders
15	CD8A	CD8a molecule	11.0
16	CD27	CD27 molecule	11.0
17	CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2	11.0
18	TRIM5	tripartite motif containing 5	11.0
19	CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	11.0
20	APOBEC3G	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	11.0
21	ATAD2	ATPase family, AAA domain containing 2	11.0
22	B3GAT1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	11.0
23	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	11.0
24	EXTL3	exostoses (multiple)-like 3	11.0
25	POLD1	polymerase (DNA directed), delta 1, catalytic subunit	11.0
26	IDO1	indoleamine 2,3-dioxygenase 1	11.0
27	POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	11.0
28	PDLIM7	PDZ and LIM domain 7 (enigma)	11.0
29	NCOA6	nuclear receptor coactivator 6	11.0
30	CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	11.0
31	ENPEP	glutamyl aminopeptidase (aminopeptidase A)	11.0
32	DDX41	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	11.0
33	CR2	complement component (3d/Epstein Barr virus) receptor 2	11.0
34	CDK9	cyclin-dependent kinase 9	11.0
35	CCR2	chemokine (C-C motif) receptor 2	11.0
36	CCNT1	cyclin T1	11.0
37	POLE	polymerase (DNA directed), epsilon, catalytic subunit	11.0
38	TAT	tyrosine aminotransferase	11.0
39	CACNA2D4	calcium channel, voltage-dependent, alpha 2/delta subunit 4	11.0
40	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0
41	TRIM37	tripartite motif containing 37	11.0
42	IL7R	interleukin 7 receptor	11.0
43	ACTG1	actin, gamma 1	11.0
44	CCR3	chemokine (C-C motif) receptor 3	11.0
45	SCD5	stearoyl-CoA desaturase 5	11.0
46	CD69	CD69 molecule	11.0
47	CD209	CD209 molecule	11.0
48	PRF1	perforin 1 (pore forming protein)	11.0
49	CD38	CD38 molecule	11.0
50	CD34	CD34 molecule	11.0

Pathways related to human immunodeficiency virus infectious disease according to GeneDecks:

(show top 50)    (show all 109)

id	Pathway	Score	Top Affiliating Genes
1	Antigen processing and presentation20	10.2	CD4, KIR2DL2, CD8A, HLA-C
2	Primary immunodeficiency20	10.0	CD4
3	Lymphocyte Signaling3	9.9	IL2RA, CD34, B2M, CD4, CD8A, FASLG
4	Immune System38	9.8	CD79A, IFNG, CCR2, KIR2DL2, CD34, CSF2
5	Graft-versus-host disease20	9.8	PRF1, HLA-C, KIR2DL2, CD28, IL2, FASLG
6	Biological oxidations38	9.8	CYP2J2, CYP3A5, CYP2C19, CYP2A6, CYP3A43, CYP3A4
7	Cyclophosphamide Pathway, Pharmacokinetics34	9.8	CYP3A4, CYP2A6, CYP2B6, CYP2C19, CYP3A5
8	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	IL15, IL2, IL2RA, FASLG, CCL4, CCL3
9	RAR-Gamma-RXR-Alpha Degradation36	9.7	IL15, IL2, IL7, CCL4, CCL3L1, CCL3
10	Chemokine Signaling36	9.4	CACNA2D4, CCL5, CCR7, CCL13, CCL3, CCR3
11	IL-6 Pathway36	9.4	IL4, IL7, CCL4, CCL2, CCL3L1, CCL3
12	Chemokine signaling pathway20	9.3	CXCR4, CCR5, CCL3L1, CCR3, CXCL12, NFKB1
13	NFAT Signaling and Lymphocyte Interactions36	9.3	CD4, IL15, IL2, IL4, IL7, CCL4
14	Regulation of eIF4 and p70S6K36	9.0	IL2, IL15, IL6, IL7, CCL4, CCL3
15	PGC1Alpha Pathway36	9.0	IL2, IL4, IL7, IL7R, CCL4, CCL3L1
16	Jak-STAT signaling pathway20	8.9	IFNA1, IL15, EPO, IL10, IL7R, IL7
17	Molecular Mechanisms of Cancer36	8.9	CXCL12, TNFRSF8, CCL5, CCR7, CCL13, CCR3
18	Intestinal immune network for IgA production20	8.6	IL2, CXCR4, CD40LG, IL4, IL10, IL15
19	Autoimmune thyroid disease20	8.5	CD28, CD40LG, IL10, IL2, IL4, FASLG
20	Endothelin-1 Signaling Pathway36	8.3	INSR, IL10, IL1B, IL2, IL4, IL6
21	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.1	IL10, IL2, IL2RA, FASLG, FAS, TNF
22	Rho Family GTPases36	8.1	IL15, IL1B, IL2, IL4, CCL4, CCL2
23	ERK Signaling36	8.0	IL10, INSR, IL2, CXCL12, IL1B, CSF3
24	Natural killer cell mediated cytotoxicity20	7.9	TNF, FAS, KIR2DL2, IFNA1, IFNG, PRF1
25	Rheumatoid arthritis20	7.9	IL15, CSF2, CXCL12, CCL3L1, CCL3, CCL5
26	Glucocorticoid Receptor Signaling36	7.8	IL2, IL2RA, IL4, IL6, IL7, IL7R
27	T cell receptor signaling pathway20	7.8	CD4, CD40LG, IL10, IL4, IFNG, TNF
28	African trypanosomiasis20	7.8	IFNG, FAS, FASLG, IL6, IDO1, IL10
29	TGF-Beta Pathway36	7.7	IL1B, IL6, IL10, IL15, IL2, CXCL12
30	Malaria20	7.7	IFNG, CCL2, TNF, CD40LG, IL10, IL1B
31	Cytokine Network36	7.6	IL2, TNF, IL10, IL15, IL1B, IL4
32	Measles20	7.5	NFKB1, IFNG, FASLG, IL2RA, IL2, FAS
33	SOCS Pathway36	7.4	IL7, CCL4, CCL2, CCL3L1, CCL3, CCL13
34	Hematopoietic cell lineage20	7.4	CD8A, CD14, CD4, CD34, CD38, IL1B
35	Allograft rejection20	7.4	CD28, CD40LG, IL10, IL2, IL4, FASLG
36	Type I diabetes mellitus20	7.3	HLA-C, TNF, PRF1, HLA-B, HLA-A, CD28
37	all-trans-Retinoic Acid Signaling in Brain36	7.2	CCL3L1, IL10, IL15, IL1B, IL2, CSF3
38	Chagas disease (American trypanosomiasis)20	7.2	IL10, IFNG, NFKB1, TNF, CCL5, CCL3
39	PEDF Induced Signaling36	7.2	CCL4, CCL2, CCL3L1, CCL3, CCL13, CCL5
40	MIF Mediated Glucocorticoid Regulation36	7.0	IL2, IL4, IL6, IL7, CCL4, CCL2
41	MIF Regulation of Innate Immune Cells36	7.0	CSF3, CD14, CXCL12, NFKB1, TNF, CCL5
42	PAK Pathway36	6.9	CCL4, CCL2, CCL3L1, CCL3, CCL13, CCL5
43	MAPK Family Pathway36	6.8	IL2RA, CXCL12, NFKB1, TNF, CCL5, CCL13
44	Akt Signaling36	6.4	CCR3, CCL3, CCL13, CCR7, CCL5, TNF
45	JAK-STAT Pathway36	6.3	IL10, CXCL12, CXCR4, EPO, NFKB1, IFNG
46	STAT3 Pathway36	6.0	CCL2, CCR5, CCL3L1, CCR3, CCL3, CCL13
47	Tec Kinases Signaling36	5.8	CD28, CD4, INSR, IL10, IL15, IL1B
48	Antioxidant Action of Vitamin-C36	5.7	CCL2, CSF3, CSF2, CXCR4, CXCL12, CCR5
49	p38 Signaling36	5.5	INSR, CD4, CD28, IL10, IL1B, CCL2
50	Cytokine-cytokine receptor interaction20	4.7	CD27, CD40LG, IL10, IL15, CCR7, CCL5

Compounds related to human immunodeficiency virus infectious disease according to GeneDecks:

(show top 50)    (show all 437)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.2	F8
2	ivig32	10.2	FASLG, CSF2, F8, CCR5, CCL4
3	pge232	10.1	IDO1, CCL5, CCL3, CCL4, FASLG, CD4
4	endotoxin32	10.1	CSF3, F8, CCL3, CCL4, FASLG, CD14
5	ionomycin32	10.0	CSF2, PTPRC, CCL3, CCL4, IL7R, IL7
6	aspartate32	9.7	CCL3, ENPEP, FASLG, APOBEC3G, CD40LG, CD14
7	ccl432	9.5	IL7, IL15, CCL4, CCL2, CXCR4, CXCL12
8	mdms32	9.2	CSF2, CXCR4, CXCL12, TAT, CCL5, CCL3
9	tuberculin32	9.1	ADA, TNFRSF8, IFNG, IL2RA, IL15, IL10
10	estrogen32	9.0	CYP1B1, F8, INSR, INS, CD34, NCOA6
11	rituximab32 34 9 9	11.9	F8, FASLG, IL2RA, IL2, IL15, IL10
12	methylcellulose32	8.8	IL4, IL15, CD34, CD14, EPO, CSF2
13	rapamycin32 42	9.7	IFNG, CCR5, IL2, INS, SELL, CYP3A5
14	formaldehyde32 18	9.7	CYP3A5, B2M, SELL, CD79A, CD4, CYP4X1
15	heparin32 9 18 9	11.5	CXCL12, TAT, ALB, F8, CCL5, CCR3
16	groalpha32	8.5	CSF2, CXCL12, TNF, CCL5, CCL3, CCR5
17	oxygen32 18	9.4	IL7, IL15, CD69, SCD5, SDHD, FAS
18	ribavirin32 34 9 9	11.3	EPO, ADA, CSF3, CSF2, IFNG, IFNA1
19	calcitriol32 42 9 18 9	12.2	B2M, CD14, CD38, EPO, CSF2, CYP2B6
20	epinephrine32 9 18 9	11.2	INSR, INS, CD69, CD79A, SELL, FASLG
21	vegf32	7.9	EPO, CSF3, CSF2, CXCR4, CXCL12, CD14
22	mip 1alpha32	7.9	CSF2, TNF, CCL5, CCL3, CCR5, CCL2
23	triptolide32	7.8	IL2, IL1B, CD14, IL6, CCL4, TNF
24	poly(i-c)32	7.7	CD69, IL15, IL1B, CSF2, TNF, IDO1
25	tarc32	7.5	CXCL12, TNF, IFNG, CCL5, CCR7, CCL13
26	zidovudine32 9 9	9.3	EPO, ADA, CSF3, CSF2, CXCR4, CXCL12
27	polyinosinic-polycytidylic acid32	7.3	IL10, IL15, TNF, HLA-B, IFNG, IFNA1
28	chloroquine32 34 9 9	10.2	CYP3A4, TNF, IFNA1, IL4, IL2RA, IL2
29	polysaccharide32	7.2	CXCR4, CXCL12, PTPRC, HLA-B, F8, CCL3
30	pentoxifylline32 9 9	9.2	SELL, CSF2, TAT, TNF, IFNG, IL6
31	simvastatin32 34 42 9 18 9	12.0	CYP3A5, CYP2C19, CYP2B6, CYP3A4, TNF, IFNG
32	ccl332	6.9	TAT, TNF, IFNG, IFNA1, CCL5, CCR7
33	thalidomide32 42 9 9	9.8	CYP2C19, TNF, IFNG, IFNA1, CCL5, FASLG
34	gm-csf32	6.8	EPO, CSF3, CSF2, TNF, IFNG, CCL5
35	histamine32 18	7.7	CCR5, CCL2, CCL4, IL7, IL4, IL2RA
36	okt332	6.7	CD40LG, CD79A, CSF2, CR2, TNF, IFNG
37	il 1032	6.6	CSF2, TNF, IFNG, CCL5, CCL3, CCR5
38	cyclosporin a32 42	7.4	CCL5, CCL3, CCR5, CCL4, FASLG, IL7
39	alanine32	5.9	CCL5, CCR7, CCL3, CCR3, CCR5, CCL4
40	prednisolone32 9 9	7.8	IL2RA, IL2, IL10, CD14, CD79A, SELL
41	rantes32	5.7	HLA-B, IDO1, IFNG, IFNA1, CCL5, CCR7
42	hydrocortisone32 9 9	7.7	INSR, INS, CD14, CYP3A4, TNF, IFNG
43	actinomycin d32	5.7	CSF2, CXCR4, CXCL12, TAT, TNF, IFNG
44	tacrolimus32 34 9 9	8.6	CYP3A5, CYP2C19, CYP3A4, TNF, HLA-B, HLA-A
45	genistein32 9 18 9	8.6	CD40LG, CD4, CD69, CD28, B2M, SELL
46	testosterone32 9 18 9	8.5	EPO, CXCR4, TAT, CYP2J2, FAS, FASLG
47	thymidine32 18	6.1	IL7, IL6, IL4, IL2RA, IL2, IL1B
48	retinoic acid32 42 18	6.7	IL6, IL1B, IL15, CD38, CD34, CD40LG
49	cycloheximide32	4.5	CSF3, CSF2, CXCR4, CXCL12, PRF1, TAT
50	tyrosine32	4.0	CYP2B6, CYP1B1, DDC, PTPRC, TNFRSF8, HLA-B

Cellular components related to human immunodeficiency virus infectious disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class I protein complex	GO:042612	9.9	B2M, HLA-A, HLA-B, HLA-C
2	phagocytic vesicle membrane	GO:030670	9.8	HLA-C, HLA-B, HLA-A, B2M
3	ER to Golgi transport vesicle membrane	GO:012507	9.5	HLA-C, HLA-B, HLA-A, B2M
4	endoplasmic reticulum membrane	GO:005789	9.2	CYP2J2, CYP3A5, CYP4X1, CYP2C19, CYP2B6, CYP2A6
5	membrane raft	GO:045121	8.7	CD79A, CD14, CD4, FAS, TNF, PTPRC
6	integral to plasma membrane	GO:005887	7.9	CCR2, CCR5, CCR3, HLA-A, HLA-B, HLA-C
7	external side of plasma membrane	GO:009897	6.7	ADA, CD40LG, CD4, CD8A, CD69, CD27
8	plasma membrane	GO:005886	5.8	HLA-B, HLA-A, ERAS, F8, CCR7, CCR3
9	extracellular region	GO:005576	5.5	IFNG, CCL5, CCL3, CCL2, CCL4, F8
10	extracellular space	GO:005615	4.3	EPO, ADA, CSF3, CSF2, IL7, IL6

Biological processes related to human immunodeficiency virus infectious disease according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	eosinophil chemotaxis	GO:048245	10.6	CCL5, CCL13, CCL3, CCR3
2	exogenous drug catabolic process	GO:042738	10.3	CYP3A4, CYP2C19, CYP2B6, CYP2A6
3	dendritic cell chemotaxis	GO:002407	10.3	CCR2, CCR5, CCR7, CXCR4, CCL5
4	positive regulation of natural killer cell chemotaxis	GO:2000503	10.3	CCL5, CCL3, CCL4
5	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	10.2	HLA-C, HLA-B, HLA-A, B2M
6	chemokine-mediated signaling pathway	GO:070098	10.2	CCR3, CXCL12, CCR2, CCL5, CCL2, CCR5
7	B cell proliferation	GO:042100	10.2	IL10, CD40LG, PTPRC, CD79A
8	positive regulation of calcium-mediated signaling	GO:050850	10.2	ADA, CD4, CCL3, CCL4
9	cellular calcium ion homeostasis	GO:006874	10.2	CCL2, CCL3, CCL13, CCL5, CXCL12, CCR2
10	entry into host cell	GO:030260	10.1	CD4, CXCR4, CCR5
11	regulation of vascular endothelial growth factor production	GO:010574	10.0	IL6, CCL2, CCR2
12	xenobiotic metabolic process	GO:006805	10.0	CYP1B1, CYP3A5, CYP3A4, CYP3A43, CYP2A6, CYP2B6
13	monocyte chemotaxis	GO:002548	9.9	CCL5, CCL3, IL6, CCL2
14	positive regulation of B cell proliferation	GO:030890	9.8	CD38, IL7, PTPRC, ADA, CD40LG, IL4
15	positive regulation of isotype switching to IgG isotypes	GO:048304	9.7	IL2, IL4, IFNG, PTPRC
16	B cell differentiation	GO:030183	9.7	CD79A, CD40LG, IL10, IL4, PTPRC
17	virus-host interaction	GO:019048	9.7	CCR5, CD209, APOBEC3G, CCR2, POLA1, TRIM5
18	elevation of cytosolic calcium ion concentration	GO:007204	9.7	CCR7, CCR3, CCR5, IL2, CXCR4, IL1B
19	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.7	EPO, CSF2, IL2, IL4
20	positive regulation of MHC class II biosynthetic process	GO:045348	9.7	CD40LG, IL10, IL4, IFNG
21	chemotaxis	GO:006935	9.7	CCL4, CXCL12, IL4, CCR2, CCL2, CCR5
22	positive regulation of interleukin-12 production	GO:032735	9.7	CD40LG, IFNG, IDO1, CCR7
23	defense response to virus	GO:051607	9.6	IL6, APOBEC3G, IFNG, PTPRC, DDX41, PRF1
24	regulation of immune response	GO:050776	9.6	CD34, HLA-C, HLA-B, HLA-A, IL4, CD40LG
25	aging	GO:007568	9.5	ADA, EPO, IL1B, IL15, CCL5, CCL2
26	protein kinase B signaling cascade	GO:043491	9.4	IL1B, CCL3, CCL5, TNF, CCL2
27	lipopolysaccharide-mediated signaling pathway	GO:031663	9.4	CCL3, CCL2, TNF, IL1B, CCL5
28	cellular response to lipopolysaccharide	GO:071222	9.3	CD14, IFNG, CCR5, IL10, CCL2
29	cellular response to organic cyclic compound	GO:071407	9.3	IL1B, CCL2, CCL5, TNF, CCL3
30	positive regulation of interferon-gamma production	GO:032729	9.2	IL2, CD40LG, CCR2, IL1B, TNF
31	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.2	IFNG, TNF, IL1B
32	cell surface receptor signaling pathway	GO:007166	9.2	IL7R, IL2RA, CD4, CD14, CD28, CD27
33	response to activity	GO:014823	9.1	INSR, TNF, CCL5, CCL2, IL10
34	positive regulation of chemokine biosynthetic process	GO:045080	9.0	IL1B, IL4, IFNG, TNF
35	positive regulation of T cell proliferation	GO:042102	9.0	IFNG, PTPRC, IL1B, CCL5, IL6, IL15
36	humoral immune response	GO:006959	8.7	IL7, CD28, CCL2, IFNG, TNF, IL6
37	cell-cell signaling	GO:007267	8.7	IL1B, IL10, INS, CARTPT, CCL5, CCL13
38	positive regulation of mitosis	GO:045840	8.7	INSR, INS, IL1B, TNF, CD28
39	cytokine-mediated signaling pathway	GO:019221	8.6	CSF3, HLA-C, B2M, HLA-B, HLA-A, IFNG
40	MAPK cascade	GO:000165	8.6	CCL2, INS, CCL5, CCL3, CCR5, IL1B
41	signal transduction	GO:007165	8.4	CXCL12, EPO, CCL13, CARTPT, IL1B, FAS
42	positive regulation of nitric oxide biosynthetic process	GO:045429	8.4	INSR, IL1B, TNF, IFNG, INS
43	anti-apoptosis	GO:006916	8.1	TNF, IL10, EPO, CD40LG, NFKB1, IL1B
44	positive regulation of cell proliferation	GO:008284	8.1	FASLG, IL6, IL2, IL15, IL7, EPO
45	immune response	GO:006955	8.1	CD4, IL15, IL2, IL2RA, IL4, IL7R
46	response to glucocorticoid stimulus	GO:051384	8.0	FAS, TAT, TNF, CCL5, CCL2, IL6
47	small molecule metabolic process	GO:044281	7.8	INS, CYP1B1, CYP2J2, TAT, ADA, CYP2C19
48	response to drug	GO:042493	7.7	IFNG, B2M, CCL5, TNF, CCL2, FAS
49	inflammatory response	GO:006954	7.5	NFKB1, CXCR4, TNF, CCL5, CCR7, CCL13
50	negative regulation of apoptotic process	GO:043066	7.3	CD38, IL4, IL6, IL7, TNF, CXCL12

Molecular functions related to human immunodeficiency virus infectious disease according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	aromatase activity	GO:070330	10.4	CYP2J2, CYP3A5, CYP4X1, CYP3A43, CYP1B1
2	DNA-directed DNA polymerase activity	GO:003887	10.4	POLE, POLD1, POLE3, POLA1
3	C-C chemokine receptor activity	GO:016493	10.2	CCR7, CCR3, CCR5, CCR2
4	CCR5 chemokine receptor binding	GO:031730	10.2	CCL4, CCL3, CCL5
5	CCR1 chemokine receptor binding	GO:031726	10.2	CCL5, CCL3, CCL4
6	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavopr	GO:016712	10.1	CYP2B6, CYP2A6, CYP3A4, CYP1B1
7	chemokine activity	GO:008009	10.0	CXCL12, CCL5, CCL13, CCL3, CCL2, CCL4
8	coreceptor activity	GO:015026	10.0	CXCR4, CCR5, CD4, CD8A, CD28
9	monooxygenase activity	GO:004497	9.9	CYP3A5, CYP2C19, CYP2B6, CYP3A43, CYP3A4, CYP1B1
10	transmembrane signaling receptor activity	GO:004888	9.9	CR2, TNFRSF8, CD4, CD69, CD27, CD79A
11	heme binding	GO:020037	9.9	CYP2J2, CYP3A5, CYP4X1, CYP2C19, CYP2B6, CYP2A6
12	electron carrier activity	GO:009055	9.8	CYP2C19, CYP4X1, CYP3A5, CYP2J2, CYP2B6, CYP2A6
13	iron ion binding	GO:005506	9.8	CYP2C19, CYP4X1, CYP3A5, CYP2J2, CYP2B6, CYP2A6
14	oxygen binding	GO:019825	9.5	CYP3A5, CYP2C19, CYP3A4, CYP1B1, ALB, IDO1
15	tumor necrosis factor receptor binding	GO:005164	9.1	TRIM37, FASLG, CD40LG, TNF
16	growth factor activity	GO:008083	8.5	CSF3, CSF2, CXCL12, IL7, IL6, IL4
17	cytokine activity	GO:005125	7.0	CD40LG, CSF3, CSF2, TNF, IFNG, CCL4
18	protein binding	GO:005515	4.5	NFKB1, DDC, PTPRC, TNF, TRIM5, TRIM37