MCID: HMN014
MIFTS: 39

Human Immunodeficiency Virus Infectious Disease

Categories: Immune diseases, Infectious diseases

Aliases & Classifications for Human Immunodeficiency Virus Infectious Disease

MalaCards integrated aliases for Human Immunodeficiency Virus Infectious Disease:

Name: Human Immunodeficiency Virus Infectious Disease 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:526
ICD10 32 B20 B20-B20
ICD9CM 34 042 042-042.99
MeSH 41 D015658
NCIt 46 C3108
UMLS 69 C0019693

Summaries for Human Immunodeficiency Virus Infectious Disease

Disease Ontology : 12 A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has material basis in Human immunodeficiency virus 1 or has material basis in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.

MalaCards based summary : Human Immunodeficiency Virus Infectious Disease is related to acquired immunodeficiency syndrome and oral tuberculosis, and has symptoms including diarrhea, fatigue and fever. An important gene associated with Human Immunodeficiency Virus Infectious Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include t cells and breast, and related phenotypes are cellular and hematopoietic system

Related Diseases for Human Immunodeficiency Virus Infectious Disease

Diseases related to Human Immunodeficiency Virus Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 acquired immunodeficiency syndrome 31.5 B2M CCR2 CCR5 CD38 CD40LG IL2
2 oral tuberculosis 10.7 IL2 TNF
3 yellow fever 10.6 CCL5 CCR5 TLR9
4 avoidant personality disorder 10.6 CCL5 CCR5 CXCR4
5 orofacial granulomatosis 10.6 CCL5 CCR5 TNF
6 plasma protein metabolism disease 10.6 CD38 CD40LG CXCR4
7 cytomegalovirus retinitis 10.6 CCR2 CCR5 TNF
8 lichen disease 10.6 CD40LG TLR9 TNF
9 middle ear disease 10.6 CD40LG TLR9 TNF
10 streptococcal toxic-shock syndrome 10.6 IL2 IL6 TNF
11 keratoconjunctivitis 10.6 IL2 TLR9 TNF
12 extramedullary plasmacytoma 10.6 B2M IL2 IL6
13 opportunistic mycosis 10.6 CD40LG TLR9 TNF
14 lacrimal apparatus disease 10.6 IL6 TLR9 TNF
15 microscopic colitis 10.6 IL2 IL6 TNF
16 burning mouth syndrome 10.6 IL2 IL6 TNF
17 non-secretory myeloma 10.6 B2M CD38 CD40LG
18 perinatal necrotizing enterocolitis 10.6 IL6 TLR9 TNF
19 scorpion envenomation 10.6 CCL5 IL6 TNF
20 progressive multifocal leukoencephalopathy 10.6 CD40LG IL2 TNF
21 intermediate uveitis 10.6 IL2 IL6 TNF
22 ileitis 10.6 IL6 TLR9 TNF
23 hematopoietic stem cell transplantation 10.6 IL2 IL6 TNF
24 uterine anomalies 10.6 IL6 TLR9 TNF
25 rheumatic fever 10.6 CD40LG IL2 TNF
26 keratoconjunctivitis sicca 10.6 IL6 TLR9 TNF
27 parasitic helminthiasis infectious disease 10.6 CD40LG TLR9 TNF
28 upper respiratory tract disease 10.6 CD40LG TLR9 TNF
29 whiplash 10.6 CCL4 CCL5 CCR5
30 syphilitic meningitis 10.6 CD40LG ENPEP ITIH4
31 vernal conjunctivitis 10.6 B2M CD40LG IL2
32 post-transplant lymphoproliferative disease 10.6 B2M IL6 TNF
33 murray valley encephalitis 10.6 CD40LG ERVW-1 IL2
34 bronchial disease 10.6 CCL5 TLR9 TNF
35 louping ill 10.6 CD40LG ERVW-1
36 paracoccidioidomycosis 10.6 IL2 IL6 TNF
37 leprosy 3 10.5 CD40LG IL2 TNF
38 waldenstrom macroglobulinemia 10.5 CD40LG CXCR4 IL6
39 aids dementia complex 10.5 B2M CXCR4 ITIH4 TNF
40 osteosclerotic myeloma 10.5 CD40LG IL6 TNF
41 rheumatoid lung disease 10.5 CD40LG ERVW-1 TNF
42 female reproductive system disease 10.5 IL6 TLR9 TNF
43 viral encephalitis 10.5 CCL5 IL6 TNF
44 hemorrhagic fever 10.5 CD40LG IL6 TNF
45 omsk hemorrhagic fever 10.5 CCL4 CCL4L1 CCL5
46 plasmodium vivax malaria 10.5 CD40LG IL6 TNF
47 spondyloarthropathy 10.5 IL2 IL6 TNF
48 macroglobulinemia 10.5 CD40LG CXCR4 IL6
49 coccidiosis 10.5 CD40LG IL2 TLR9 TNF
50 pulmonary sarcoidosis 10.5 CCL5 CCR5 IL2 TNF

Graphical network of the top 20 diseases related to Human Immunodeficiency Virus Infectious Disease:



Diseases related to Human Immunodeficiency Virus Infectious Disease

Symptoms & Phenotypes for Human Immunodeficiency Virus Infectious Disease

Symptoms:

12
  • diarrhea
  • fatigue
  • fever
  • vaginal yeast infection
  • headache
  • mouth sores
  • muscle aches
  • sore throat
  • swollen lymph gl

MGI Mouse Phenotypes related to Human Immunodeficiency Virus Infectious Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 TNF CD40LG CXCR4 B2M IL2 CCR2
2 hematopoietic system MP:0005397 10.03 CD40LG TNF CXCR4 B2M CARTPT IL2
3 immune system MP:0005387 9.97 TNF CD40LG CXCR4 B2M ENPEP IL2
4 digestive/alimentary MP:0005381 9.92 TNF CXCR4 B2M IL2 CCR2 IL6
5 liver/biliary system MP:0005370 9.5 TNF B2M IL2 CCR2 IL6 ITIH4
6 neoplasm MP:0002006 9.23 TNF CXCR4 B2M IL2 CCR2 IL6

Drugs & Therapeutics for Human Immunodeficiency Virus Infectious Disease

Search Clinical Trials , NIH Clinical Center for Human Immunodeficiency Virus Infectious Disease

Genetic Tests for Human Immunodeficiency Virus Infectious Disease

Anatomical Context for Human Immunodeficiency Virus Infectious Disease

MalaCards organs/tissues related to Human Immunodeficiency Virus Infectious Disease:

38
T Cells, Breast

Publications for Human Immunodeficiency Virus Infectious Disease

Variations for Human Immunodeficiency Virus Infectious Disease

Expression for Human Immunodeficiency Virus Infectious Disease

Search GEO for disease gene expression data for Human Immunodeficiency Virus Infectious Disease.

Pathways for Human Immunodeficiency Virus Infectious Disease

Pathways related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
2
Show member pathways
13.62 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
3
Show member pathways
13.32 B2M CCL4 CCL5 CCR2 CCR5 CD40LG
4
Show member pathways
13.21 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
5
Show member pathways
13.2 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
6
Show member pathways
12.87 CCL4 CCL4L1 CCL5 CCR2 CCR5 CXCR4
7
Show member pathways
12.85 CCL5 CCR5 CXCR4 IL6 TNF
8
Show member pathways
12.84 B2M CD40LG CXCR4 IL2 IL6 TNF
9
Show member pathways
12.77 CCL5 IL2 IL6 TLR9 TNF
10
Show member pathways
12.68 CD40LG IL2 IL6 TLR9 TNF
11
Show member pathways
12.68 CCL4 CCL4L1 CCL5 IL6 S100B TNF
12
Show member pathways
12.41 CCR5 CD40LG IL2 IL6 TNF
13
Show member pathways
12.4 CCL4 CCL4L1 CCL5 IL2 IL6 TLR9
14
Show member pathways
12.3 CCL5 IL2 IL6 TNF
15
Show member pathways
12.18 CCL4 CCL4L1 CCL5 CCR2 CCR5 CXCR4
16 12.01 CCR2 IL2 IL6 TNF
17 11.98 CD38 IL2 IL6 TNF
18
Show member pathways
11.94 CCL4 CCL5 CCR2 CCR5 CXCR4
19
Show member pathways
11.91 IL2 IL6 TLR9 TNF
20
Show member pathways
11.91 B2M CCL4 CCL4L1 CCR5 IL2
21 11.85 CCL4 CCL4L1 CD40LG TNF
22 11.82 CCR2 CCR5 CXCR4 IL2 IL6
23 11.81 CCL5 IL6 TNF
24 11.79 CCL4 CCL4L1 IL6
25 11.79 B2M CCL5 CCR2 CD38 CD40LG CXCR4
26
Show member pathways
11.73 CD40LG IL2 TNF
27 11.67 CD40LG IL6 TLR9 TNF
28 11.67 CD38 IL2 IL6 TLR9 TNF
29
Show member pathways
11.64 CD40LG IL2 IL6 TNF
30
Show member pathways
11.62 B2M IL2 TNF
31 11.56 CD38 CD40LG CXCR4
32 11.53 IL2 IL6 TNF
33 11.49 CD40LG IL6 TLR9 TNF
34 11.45 CCL4 CCL5 CCR2 IL6 TNF
35
Show member pathways
11.37 CCL4 IL2 TNF
36 11.35 IL6 TLR9 TNF
37 11.26 IL2 IL6 TNF
38 11.12 CCL4 CCL5 CCR2 CCR5 IL6 TNF
39 10.97 CCL4 CCL4L1 CCL5 CD40LG IL2 IL6
40 10.93 CCL4 CCL4L1 CCL5 CD40LG IL2 IL6

GO Terms for Human Immunodeficiency Virus Infectious Disease

Cellular components related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 B2M CARTPT CCL4 CCL5 CD40LG IL2
2 cell surface GO:0009986 9.73 B2M CCR5 CD38 CD40LG CXCR4 TNF
3 external side of plasma membrane GO:0009897 9.43 B2M CCR2 CCR5 CD40LG ENPEP TNF
4 extracellular space GO:0005615 9.36 B2M CARTPT CCL4 CCL4L1 CCL5 CD40LG

Biological processes related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.97 CARTPT CCL4 CCL4L1 CCL5 CD40LG IL2
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.94 CCL4 CCL4L1 CCL5 TNF
3 cell-cell signaling GO:0007267 9.91 CARTPT CCL4 CCL5 CCR5 ENPEP IL2
4 chemotaxis GO:0006935 9.88 CCL4 CCL5 CCR2 CCR5 CXCR4
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 CD40LG IL6 TLR9 TNF
6 cellular response to interferon-gamma GO:0071346 9.86 CCL4 CCL4L1 CCL5
7 cellular response to interleukin-1 GO:0071347 9.85 CCL4 CCL4L1 CCL5
8 regulation of insulin secretion GO:0050796 9.84 CARTPT CCL5 TNF
9 positive regulation of inflammatory response GO:0050729 9.83 CCR2 IL2 TLR9
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 CCL5 IL2 IL6
11 neutrophil chemotaxis GO:0030593 9.83 CCL4 CCL4L1 CCL5
12 response to virus GO:0009615 9.83 CCL4 CCL5 CXCR4 TNF
13 response to glucocorticoid GO:0051384 9.82 IL6 S100B TNF
14 response to cytokine GO:0034097 9.81 CCL5 CD38 ITIH4
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 CCL5 IL6 TNF
16 immune response GO:0006955 9.81 B2M CCL4 CCL5 CCR2 CCR5 CD40LG
17 humoral immune response GO:0006959 9.8 CCR2 IL6 TNF
18 positive regulation of T cell proliferation GO:0042102 9.8 CCL5 CD40LG IL2 IL6
19 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 CCR2 CCR5 CD38 CXCR4 IL2
20 positive regulation of interleukin-6 production GO:0032755 9.78 IL6 TLR9 TNF
21 positive regulation of interferon-gamma production GO:0032729 9.77 CCR2 IL2 TNF
22 negative regulation of viral genome replication GO:0045071 9.76 APOBEC3G CCL5 TNF
23 positive regulation of B cell proliferation GO:0030890 9.75 CD38 IL2 TLR9
24 positive regulation of chemokine production GO:0032722 9.69 IL6 TLR9 TNF
25 response to molecule of bacterial origin GO:0002237 9.68 B2M TLR9
26 positive regulation of immunoglobulin secretion GO:0051024 9.68 IL2 IL6
27 negative regulation by host of viral transcription GO:0043922 9.68 CCL4 CCL5
28 positive regulation of T cell chemotaxis GO:0010820 9.67 CCL5 CCR2
29 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
30 monocyte chemotaxis GO:0002548 9.65 CCL4 CCL4L1 CCL5 CCR2 IL6
31 negative regulation of bone resorption GO:0045779 9.63 CARTPT CD38 IL6
32 fusion of virus membrane with host plasma membrane GO:0019064 9.62 CCR5 CXCR4
33 negative regulation of macrophage apoptotic process GO:2000110 9.62 CCL5 CCR5
34 dendritic cell chemotaxis GO:0002407 9.62 CCL5 CCR2 CCR5 CXCR4
35 positive regulation of natural killer cell chemotaxis GO:2000503 9.61 CCL4 CCL5
36 regulation of immunoglobulin secretion GO:0051023 9.6 CD40LG TNF
37 entry into host cell GO:0030260 9.56 CCR5 CXCR4
38 regulation of vascular endothelial growth factor production GO:0010574 9.55 CCR2 IL6
39 chemokine-mediated signaling pathway GO:0070098 9.43 CCL4 CCL4L1 CCL5 CCR2 CCR5 CXCR4
40 inflammatory response GO:0006954 9.32 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
41 G-protein coupled receptor signaling pathway GO:0007186 10.14 CARTPT CCL4 CCL4L1 CCL5 CCR2 CCR5

Molecular functions related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.87 APOBEC3G B2M CCL4 CCL5 CD38 S100B
2 C-C chemokine receptor activity GO:0016493 9.43 CCR2 CCR5
3 chemokine activity GO:0008009 9.43 CCL4 CCL4L1 CCL5
4 C-C chemokine binding GO:0019957 9.4 CCR5 CXCR4
5 CCR5 chemokine receptor binding GO:0031730 9.37 CCL4 CCL5
6 CCR1 chemokine receptor binding GO:0031726 9.16 CCL4 CCL5
7 chemokine receptor activity GO:0004950 9.13 CCR2 CCR5 CXCR4
8 cytokine activity GO:0005125 9.1 CCL4 CCL5 CD40LG IL2 IL6 TNF

Sources for Human Immunodeficiency Virus Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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