MCID: HMN014
MIFTS: 45

Human Immunodeficiency Virus Infectious Disease

Categories: Infectious diseases, Immune diseases

Aliases & Classifications for Human Immunodeficiency Virus Infectious Disease

MalaCards integrated aliases for Human Immunodeficiency Virus Infectious Disease:

Name: Human Immunodeficiency Virus Infectious Disease 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:526
ICD10 33 B20 B20-B20
ICD9CM 35 042 042-042.99
MeSH 42 D015658
NCIt 47 C3108
UMLS 69 C0019693

Summaries for Human Immunodeficiency Virus Infectious Disease

Disease Ontology : 12 A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has material basis in Human immunodeficiency virus 1 or has material basis in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.

MalaCards based summary : Human Immunodeficiency Virus Infectious Disease is related to scirrhous adenocarcinoma and acquired immunodeficiency syndrome. An important gene associated with Human Immunodeficiency Virus Infectious Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Isoniazid and Abacavir have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and liver, and related phenotypes are cellular and hematopoietic system

Related Diseases for Human Immunodeficiency Virus Infectious Disease

Diseases related to Human Immunodeficiency Virus Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
id Related Disease Score Top Affiliating Genes
1 scirrhous adenocarcinoma 11.1 IL2 TNF
2 acquired immunodeficiency syndrome 11.0
3 alcoholic neuropathy 11.0 CD40LG CD79A
4 calloso-genital dysplasia 10.9 CD40LG CD79A
5 gonococcal endophthalmia 10.9 CCL5 CCR5 TLR9
6 chronic cervicitis 10.9 CCL5 CCR5 CXCR4
7 variola major 10.9 CD40LG CD79A
8 mu chain disease 10.9 CD40LG CD79A
9 rabies 10.9 CD40LG CD79A
10 familial retinoblastoma 10.9 CD40LG CD79A
11 anti-basement membrane glomerulonephritis 10.9 CD40LG CD79A
12 microinvasive cervical squamous cell carcinoma 10.9 CD40LG CD79A
13 metabolic acidosis 10.9 CD38 CD40LG CXCR4
14 fetal erythroblastosis 10.9 CD40LG CD79A
15 spinal canal and spinal cord meningioma 10.9 CD40LG CD79A
16 trichostrongyloidiasis 10.9 CD40LG CD79A
17 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.9 CCR2 CCR5 TNF
18 spirillary rat-bite fever 10.9 IL2 IL6 TNF
19 leukodystrophy 10.9 CD40LG CD79A
20 retinal microaneurysm 10.9 CD40LG CD79A
21 heart septal defect 10.9 CD40LG CD79A
22 sheehan syndrome 10.9 S100B TLR9 TNF
23 cryptorchidism arachnodactyly mental retardation 10.9 CD40LG CD79A
24 solitary plasmacytoma of chest wall 10.9 B2M IL2 IL6
25 mucocutaneous leishmaniasis 10.9 IL2 TLR9 TNF
26 brucella canis brucellosis 10.9 IL6 TLR9 TNF
27 hemangioma of orbit 10.9 CD79A IL2 TNF
28 tinea favosa 10.9 IL2 IL6 TNF
29 myeloid sarcoma 10.9 IL6 TLR9 TNF
30 ceruminous carcinoma 10.9 CD40LG IL2 TNF
31 plantar wart 10.9 CD79A IL2 TNF
32 smarca4-deficient sarcoma of thorax 10.9 CCL5 IL6 TNF
33 cyclosporiasis 10.9 IL2 IL6 TNF
34 oculo-cerebral dysplasia 10.9 CD40LG CD79A TLR9
35 combined thymoma 10.9 CD38 CD79A
36 endogenous depression 10.9 CD40LG IL2 TNF
37 breast disease 10.9 IL6 TLR9 TNF
38 hemophagocytic lymphohistiocytosis 10.9 IL2 IL6 TNF
39 ulcerative colitis 10.8 IL6 S100B TNF
40 bolivian hemorrhagic fever 10.8 CD79A IL2 TNF
41 benign infantile focal epilepsy with midline spikes and wave during sleep 10.8 CCL4 CCL5 CCR5
42 diphyllobothriasis 10.8 CD40LG ENPEP ITIH4
43 spontaneous ocular nystagmus 10.8 CCL5 TLR9 TNF
44 dehydration polycythemia 10.8 CD79A TLR9 TNF
45 left bundle branch hemiblock 10.8 CD40LG IL2 TNF
46 discharging ear 10.8 CD40LG ERVW-1
47 autoimmune disease of cardiovascular system 10.8 CD40LG CD79A TLR9
48 spondylolysis 10.8 IL6 TLR9 TNF
49 aortic arch interruption 10.8 IL6 TNF
50 orbital osteomyelitis 10.8 IL2 IL6 TNF

Graphical network of the top 20 diseases related to Human Immunodeficiency Virus Infectious Disease:



Diseases related to Human Immunodeficiency Virus Infectious Disease

Symptoms & Phenotypes for Human Immunodeficiency Virus Infectious Disease

MGI Mouse Phenotypes related to Human Immunodeficiency Virus Infectious Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 B2M CCR2 CCR5 CD38 CD40LG CD79A
2 hematopoietic system MP:0005397 10.13 TNF B2M CARTPT CCL5 CCR2 CCR5
3 homeostasis/metabolism MP:0005376 10.07 B2M CARTPT CCR2 CCR5 CD38 CD40LG
4 immune system MP:0005387 10 CD40LG CD79A CXCR4 ENPEP IL2 IL6
5 digestive/alimentary MP:0005381 9.97 B2M CCR2 CCR5 CXCR4 IL2 IL6
6 liver/biliary system MP:0005370 9.56 B2M CCR2 CCR5 CD79A IL2 IL6
7 neoplasm MP:0002006 9.28 B2M CCR2 CCR5 CD79A CXCR4 IL2

Drugs & Therapeutics for Human Immunodeficiency Virus Infectious Disease

Drugs for Human Immunodeficiency Virus Infectious Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 963)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved Phase 4,Phase 3,Phase 2,Phase 1 54-85-3 3767
2
Abacavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 136470-78-5 65140 441300
3
Lamivudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 134678-17-4 60825
4
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 143491-57-0 60877
5
Lopinavir Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 192725-17-0 92727
6
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 155213-67-5 392622
7
Artemether Approved Phase 4,Phase 3,Phase 1 71963-77-4 119380 68911
8
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 154598-52-4 64139
9
Lumefantrine Approved Phase 4,Phase 3,Phase 1 82186-77-4 6437380
10
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
11
Nevirapine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 129618-40-2 4463
12
Rifampin Approved Phase 4,Phase 3,Phase 2,Phase 1 13292-46-1 5458213 5381226
13
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 2,Phase 1 723-46-6 5329
14
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 738-70-5 5578
15
Didanosine Approved Phase 4,Phase 3,Phase 2,Phase 1 69655-05-6 50599
16
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
17
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
18
Darunavir Approved Phase 4,Phase 3,Phase 2,Phase 1 635728-49-3, 206361-99-1 213039
19
Pentoxifylline Approved, Investigational Phase 4,Phase 2,Phase 1 6493-05-6 4740
20
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1 36791-04-5 37542
21
Candesartan Approved Phase 4 139481-59-7 2541
22
Lercanidipine Approved, Investigational Phase 4 100427-26-7 65866
23
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 2,Phase 1 128794-94-5 5281078
24
Mycophenolic acid Approved Phase 4,Phase 2,Phase 1 24280-93-1 446541
25
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 30516-87-1 35370
26
Nelfinavir Approved Phase 4,Phase 3,Phase 2,Phase 1 159989-64-7 64143
27
Stavudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 3056-17-5 18283
28
Amprenavir Approved Phase 4,Phase 2,Phase 3,Phase 1 161814-49-9 65016
29
Maraviroc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 376348-65-1 3002977
30
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 52485-79-7 40400 644073
31
Heroin Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 561-27-3 5462328
32
Ethambutol Approved Phase 4,Phase 3,Phase 2,Phase 1 74-55-5 3279 14052
33
Pyrazinamide Approved Phase 4,Phase 3,Phase 2,Phase 1 98-96-4 1046
34
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 198153-51-4 5360545
35
Rifabutin Approved Phase 4,Phase 3,Phase 2,Phase 1 72559-06-9 6323490
36 Dolutegravir Approved Phase 4,Phase 3,Phase 2,Phase 1 1051375-16-6 54726191
37
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
38
Ezetimibe Approved Phase 4,Phase 1 163222-33-1 150311
39
Fenofibrate Approved Phase 4,Phase 3,Phase 2,Phase 1 49562-28-9 3339
40
Pravastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 81093-37-0 54687
41
Rilpivirine Approved Phase 4,Phase 3,Phase 2,Phase 1 500287-72-9
42
Entecavir Approved, Investigational Phase 4,Phase 2,Phase 3 142217-69-4 153941
43
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
44
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
45
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
46
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
47
rituximab Approved Phase 4,Phase 2,Phase 1 174722-31-7 10201696
48
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
49
Enfuvirtide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 159519-65-0 16130199
50
Ganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 82410-32-0 3454

Interventional clinical trials:

(show top 50) (show all 5569)

id Name Status NCT ID Phase Drugs
1 Diagnosis and Treatment of Co-infection With Human Immunodeficiency Virus /Latent Tuberculosis Infection (HIV/TBL) Unknown status NCT01875952 Phase 4 Isoniazid
2 Pilot Study With Isentress (Raltegravir) and Epzicom (Abacavir/Lamivudine) in Treatment Naive HIV-Infected Subjects Unknown status NCT00740064 Phase 4 Raltegravir and Abacavir/Lamivudine
3 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4 Truvada (tenofovir/emitricitabine);Kaletra (lopinavir/ritonavir)
4 Drug Interaction Between Coartem® and Nevirapine, Efavirenz or Rifampicin in HIV Positive Ugandan Patients Unknown status NCT00620438 Phase 4 Lumefantrine-artemether and nevirapine;lumefantrine-artemether and efavirenz;Lumefantrine-artemether and rifampicin
5 PrEP Demonstration Project (PRELUDE Study) Unknown status NCT02206555 Phase 4 emtricitabine/tenofovir disoproxil fumarate
6 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4 cotrimoxazole;Placebo
7 Once Daily 3TC, Efavirenz and ddI for HIV Infection Unknown status NCT00214435 Phase 4 once daily minimum 3-drug regimen of anti-retroviral medications
8 Safety and Efficacy Study Comparing Raltegravir to a Protease Inhibitor in Treatment-naïve, HIV/Hepatitis C Drug Users Unknown status NCT01105611 Phase 4 Raltegravir;Atazanavir/Ritonavir
9 Effect of a Non-tenofovir, Non-efavirenz-based HIV Regimen on Bone Density and Vitamin D Levels in African-American Patients With HIV Infection Unknown status NCT01343225 Phase 4 atripla;darunavir ritonavir raltegravir
10 Early Antiviral Therapy for Critically Ill HIV Infected Patients Unknown status NCT01455688 Phase 4 early HAART;Late HAART
11 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4 Protease Inhibitor;Standard-of-care Antiretroviral therapy
12 Effect of HIV and/or Active Tuberculosis on the Immune Responses to Trivalent Influenza Vaccine (TIV) in Adults Unknown status NCT01811823 Phase 4
13 Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients Unknown status NCT02008214 Phase 4 Pentoxifylline;Placebo
14 The Self-Collection Study: a Study of Self-collected HPV Testing and Results Counseling Unknown status NCT01843478 Phase 4
15 Effects of Antihypertensive Treatment in HIV Infected Patients: Candesartan Versus Lercanidipine Unknown status NCT00564057 Phase 4 candesartan;lercanidipine
16 Mycophenolate Mofetil in Antiretroviral Naïve Patients 2 (MAN2 Study) Unknown status NCT00120419 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
17 Evaluation of the Efficacy and Safety Between Two Antiretroviral Regimens, in HIV-1-infected Treatment-naïve Subjects With Low CD4 Counts Unknown status NCT01928407 Phase 4 DARUNAVIR;ATAZANAVIR
18 Safety and Effectiveness of TRIZIVIR (Abacavir/Lamivudine/Zidovudine) With Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs Unknown status NCT00011895 Phase 4 Abacavir sulfate, Lamivudine and Zidovudine;Efavirenz
19 Simplification From Protease Inhibitors to Raltegravir Unknown status NCT00941083 Phase 4 Raltegravir (Use RAL as a simplification strategy);Raltegravir (Use RAL as a simplification strategy);Raltegravir (Use RAL as a simplification strategy)
20 A Comparison of Virco®TYPE HIV-1 Testing Versus Expert Interpretation of Genotypic Results for Control of HIV-1 Replication Unknown status NCT00840762 Phase 4
21 Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya Unknown status NCT01015989 Phase 4
22 HIV Persistence and Viral Reservoirs Unknown status NCT01025427 Phase 4 Raltegravir, tenofovir/emtricitabine
23 Lopinavir/Ritonavir or Efavirenz as First-line Antiretroviral Therapy Unknown status NCT01049685 Phase 4 First-line Antiretroviral Therapy
24 Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus Unknown status NCT00797030 Phase 4 cyclosporine and sodium carboximethycellulose;sodium carboximethycellulose
25 Treatment With Nelfinavir or Efavirenz of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs Unknown status NCT00005000 Phase 4 Nelfinavir mesylate;Efavirenz;Lamivudine;Keyhole-Limpet Hemocyanin;Stavudine;Zidovudine;Didanosine
26 RAltegravir Switch STudy: Effects on Endothelial Recovery Unknown status NCT01453933 Phase 4 raltegravir
27 Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment Unknown status NCT00005017 Phase 4 Ritonavir;Abacavir sulfate;Amprenavir;Efavirenz;Lamivudine;Stavudine
28 Effect of Maraviroc (MCV) on the Immunological Recovery of HIV-1 Discordant Patients With CD4 Lymphocyte Counts Below 200 Cells/mm3 Unknown status NCT01235013 Phase 4 Maraviroc
29 BLADE: Comparison of Once Daily Lopinavir/Ritonavir to Lopinavir/Ritonavir BID Dosing in HIV-Infected Subjects Unknown status NCT00388492 Phase 4
30 Integrating Buprenorphine Into HIV Treatment Unknown status NCT00241930 Phase 4
31 Evaluation of the Pharmacokinetics of Antituberculosis Drugs and Tuberculosis Treatment Outcomes Unknown status NCT01782950 Phase 4 Rifampicin, Isoniazid, Ethambutol, Pyrazinamide
32 Two Different Treatments 24 vs 48 Weeks Chronic Hepatitis C Genotypes 2 and/or 3 in co-Infected HIV-HCV Unknown status NCT00611819 Phase 4 Peg interferon + Ribavirin;Peg interferon + Ribavirin
33 Raltegravir + Lamivudine/Abacavir in HIV/Tuberculosis Co-Infected Patients Unknown status NCT01059422 Phase 4 Raltegravir; Abacavir/Lamivudine
34 Effects of Mycophenolate Mofetil (MMF) on Surrogate Markers for Cardiovascular Disease in HIV-1 Infected Patients Unknown status NCT00247494 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
35 Study on the Antiviral Therapy and Immune Reconstitution of Chinese HIV/AIDS Patients Unknown status NCT00872417 Phase 4 first line ARV (3TC+NVP+D4T or 3TC+NVP+AZT);second line ARV therapy (3TC+TDF+LPV/RTV)
36 SHARE: Simple HAART With Abacavir, Reyataz, and Epivir Unknown status NCT00426296 Phase 4 atazanavir (Reyataz);ritonavir (Norvir)
37 Effects of 2 Initial Standard Antiretroviral Combinations Therapies on Lipid Metabolism Unknown status NCT00759070 Phase 4 Tenofovir + emtricitabine + efavirenz;Tenofovir + emtricitabine + lopinavir/ritonavir
38 Interferon-Gamma Release Assays in Tuberculosis (TB) - HIV Co-infected Children Unknown status NCT00604617 Phase 4 RT-23
39 Raltegravir and Atazanavir Replacing Current Suppressive Treatment Because of Side Effects in Current Treatment Unknown status NCT00751153 Phase 4 Raltegravir and Atazanavir
40 Buprenorphine and Integrated HIV Care Evaluation Unknown status NCT00124358 Phase 4 Buprenorphine
41 Impact of Starting a Dolutegravir-based Regimen on HIV-1 Proviral DNA Reservoir Of Treatment Naïve and Experienced Patients Unknown status NCT02370979 Phase 4
42 Equivalence of Boosted Atazanavir Based Regimens and Currently Effective HAART Regimens Unknown status NCT00940771 Phase 4 Boosted Atazanavir
43 Does Rosuvastatin Delay Progression of Atherosclerosis in HIV Unknown status NCT01813357 Phase 4 Rosuvastatin
44 7-valent Pneumococcal Conjugated Vaccination Unknown status NCT00885625 Phase 4
45 Adjusting Antiretroviral Therapy Dosage Using Therapeutic Drug Monitoring Unknown status NCT00836212 Phase 4 Reducing dose of Lopinavir;Reducing dose of efavirenz
46 MEDICLAS Study (Metabolic Effects of Different Classes of AntiretroviralS) Unknown status NCT00122226 Phase 4 Lopinavir/ritonavir + zidovudine + lamivudine;Lopinavir/ritonavir + nevirapine
47 Coadministration of Ezetimibe With Fenofibrate Versus Pravastatin Monotherapy for the Treatment of Hyperlipidaemia in HIV-infected Patients Unknown status NCT00843661 Phase 4 ezetimibe;fenofibrate;pravastatin
48 Comparing a Nucleoside-Analogue-Sparing Regimen and a Protease-Inhibitor-Sparing Regimen in HIV Infected Patients Unknown status NCT00135460 Phase 4 nucleoside analogue sparing HAART regimen
49 Impact of Raltegravir on the Viral Reservoirs Unknown status NCT01249560 Phase 4
50 Efficacy and Safety of Raltegravir (RAL) in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir

Search NIH Clinical Center for Human Immunodeficiency Virus Infectious Disease

Genetic Tests for Human Immunodeficiency Virus Infectious Disease

Anatomical Context for Human Immunodeficiency Virus Infectious Disease

MalaCards organs/tissues related to Human Immunodeficiency Virus Infectious Disease:

39
Testes, T Cells, Liver, Bone, Lung, Eye, Brain

Publications for Human Immunodeficiency Virus Infectious Disease

Variations for Human Immunodeficiency Virus Infectious Disease

Expression for Human Immunodeficiency Virus Infectious Disease

Search GEO for disease gene expression data for Human Immunodeficiency Virus Infectious Disease.

Pathways for Human Immunodeficiency Virus Infectious Disease

Pathways related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 37)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 B2M CCL4 CCL5 CCR2 CCR5 CD40LG
2
Show member pathways
13.84 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
3
Show member pathways
13.62 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
4
Show member pathways
13.32 B2M CCL4 CCL5 CCR2 CCR5 CD40LG
5
Show member pathways
13.21 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
6
Show member pathways
13.17 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
7
Show member pathways
12.86 CCL4 CCL4L1 CCL5 CCR2 CCR5 CXCR4
8
Show member pathways
12.84 CCL5 CCR5 CXCR4 IL6 TNF
9
Show member pathways
12.83 B2M CD40LG CXCR4 IL2 IL6 TNF
10
Show member pathways
12.82 CCL4 CCL4L1 CCL5 IL2 IL6 TLR9
11
Show member pathways
12.76 CCL5 IL2 IL6 TLR9 TNF
12
Show member pathways
12.69 CCL4 CCL4L1 CCL5 IL6 S100B TNF
13
Show member pathways
12.67 CD40LG IL2 IL6 TLR9 TNF
14
Show member pathways
12.41 CCR5 CD40LG IL2 IL6 TNF
15 11.99 CCR2 IL2 IL6 TNF
16
Show member pathways
11.96 CCL4 CCL5 CCR2 CCR5 CXCR4
17
Show member pathways
11.92 IL2 IL6 TLR9 TNF
18 11.92 CD38 CD79A IL2 IL6 TNF
19
Show member pathways
11.88 B2M CCL4 CCL4L1 CCR5 IL2
20 11.87 CCR2 CCR5 CXCR4 IL2 IL6
21 11.85 CCL4 CCL4L1 CD40LG TNF
22 11.82 B2M CCL5 CCR2 CD38 CD40LG CD79A
23 11.78 CCL4 CCL4L1 IL6
24
Show member pathways
11.72 CD40LG IL2 TNF
25 11.69 CD40LG IL6 TLR9 TNF
26 11.65 CD38 IL2 IL6 TLR9 TNF
27
Show member pathways
11.64 CD40LG IL2 IL6 TNF
28
Show member pathways
11.61 B2M IL2 TNF
29 11.54 CD38 CD40LG CXCR4
30 11.52 IL2 IL6 TNF
31 11.5 CD40LG IL6 TLR9 TNF
32 11.45 CCL4 CCL5 CCR2 IL6 TNF
33
Show member pathways
11.41 CCL4 IL2 TNF
34 11.34 IL6 TLR9 TNF
35 11.26 IL2 IL6 TNF
36 11.12 CCL4 CCL5 CCR2 CCR5 IL6 TNF
37 10.93 CCL4 CCL4L1 CCL5 CD40LG IL2 IL6

GO Terms for Human Immunodeficiency Virus Infectious Disease

Cellular components related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 B2M CARTPT CCL4 CCL5 CD40LG IL2
2 cell surface GO:0009986 9.73 B2M CCR5 CD38 CD40LG CXCR4 TNF
3 extracellular space GO:0005615 9.7 B2M CARTPT CCL4 CCL4L1 CCL5 CD40LG
4 external side of plasma membrane GO:0009897 9.17 B2M CCR5 CD40LG CD79A ENPEP IL6

Biological processes related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 42)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 CCL4 CCL4L1 CCL5 IL6 TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 CD40LG IL6 TLR9 TNF
3 cell-cell signaling GO:0007267 9.88 CARTPT CCL4 CCL5 CCR5 ENPEP IL2
4 cellular response to tumor necrosis factor GO:0071356 9.87 CCL4 CCL4L1 CCL5 IL6
5 response to virus GO:0009615 9.86 CCL4 CCL5 CXCR4 TNF
6 response to glucocorticoid GO:0051384 9.85 IL6 S100B TNF
7 regulation of insulin secretion GO:0050796 9.85 CARTPT CCL5 TNF
8 chemotaxis GO:0006935 9.85 CCL4 CCL5 CCR2 CCR5 CXCR4
9 neutrophil chemotaxis GO:0030593 9.84 CCL4 CCL4L1 CCL5
10 positive regulation of inflammatory response GO:0050729 9.83 CCR2 IL2 TLR9
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 CCL5 IL2 IL6
12 cellular response to interferon-gamma GO:0071346 9.83 CCL4 CCL4L1 CCL5
13 cellular response to interleukin-1 GO:0071347 9.83 CCL4 CCL4L1 CCL5 IL6
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.82 CCL5 IL6 TNF
15 immune response GO:0006955 9.81 B2M CCL4 CCL5 CCR2 CCR5 CD40LG
16 positive regulation of interleukin-6 production GO:0032755 9.8 IL6 TLR9 TNF
17 positive regulation of T cell proliferation GO:0042102 9.8 CCL5 CD40LG IL2 IL6
18 positive regulation of interferon-gamma production GO:0032729 9.79 CCR2 IL2 TNF
19 negative regulation of viral genome replication GO:0045071 9.78 APOBEC3G CCL5 TNF
20 response to cytokine GO:0034097 9.78 CCL5 CD38 IL6 ITIH4
21 positive regulation of cytosolic calcium ion concentration GO:0007204 9.77 CCR2 CCR5 CD38 CXCR4 IL2
22 response to molecule of bacterial origin GO:0002237 9.69 B2M TLR9
23 positive regulation of chemokine production GO:0032722 9.69 IL6 TLR9 TNF
24 positive regulation of immunoglobulin secretion GO:0051024 9.68 IL2 IL6
25 negative regulation by host of viral transcription GO:0043922 9.68 CCL4 CCL5
26 positive regulation of T cell chemotaxis GO:0010820 9.68 CCL5 CCR2
27 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
28 fusion of virus membrane with host plasma membrane GO:0019064 9.64 CCR5 CXCR4
29 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.64 IL6 TNF
30 positive regulation of transmission of nerve impulse GO:0051971 9.63 CARTPT IL6
31 positive regulation of natural killer cell chemotaxis GO:2000503 9.63 CCL4 CCL5
32 regulation of immunoglobulin secretion GO:0051023 9.62 CD40LG TNF
33 monocyte chemotaxis GO:0002548 9.62 CCL4 CCL4L1 CCL5 IL6
34 negative regulation of bone resorption GO:0045779 9.61 CARTPT CD38 IL6
35 positive regulation of B cell proliferation GO:0030890 9.6 CD38 IL2
36 regulation of vascular endothelial growth factor production GO:0010574 9.58 CCR2 IL6
37 entry into host cell GO:0030260 9.58 CCR5 CXCR4
38 dendritic cell chemotaxis GO:0002407 9.56 CCL5 CCR2 CCR5 CXCR4
39 chemokine-mediated signaling pathway GO:0070098 9.43 CCL4 CCL4L1 CCL5 CCR2 CCR5 CXCR4
40 inflammatory response GO:0006954 9.32 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
41 G-protein coupled receptor signaling pathway GO:0007186 10.15 CARTPT CCL4 CCL4L1 CCL5 CCR2 CCR5
42 immune system process GO:0002376 10.08 APOBEC3G B2M CD79A IL2 TLR9

Molecular functions related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.88 APOBEC3G CCL5 CCR2 CD79A S100B TLR9
2 C-C chemokine receptor activity GO:0016493 9.43 CCR2 CCR5
3 chemokine activity GO:0008009 9.43 CCL4 CCL4L1 CCL5
4 C-C chemokine binding GO:0019957 9.37 CCR5 CXCR4
5 CCR5 chemokine receptor binding GO:0031730 9.32 CCL4 CCL5
6 CCR1 chemokine receptor binding GO:0031726 9.16 CCL4 CCL5
7 chemokine receptor activity GO:0004950 9.13 CCR2 CCR5 CXCR4
8 cytokine activity GO:0005125 9.1 CCL4 CCL5 CD40LG IL2 IL6 TNF

Sources for Human Immunodeficiency Virus Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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44 MGI
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48 NDF-RT
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52 Novoseek
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55 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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