MCID: HMN001
MIFTS: 22

Human Monocytic Ehrlichiosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Human Monocytic Ehrlichiosis

MalaCards integrated aliases for Human Monocytic Ehrlichiosis:

Name: Human Monocytic Ehrlichiosis 12 50 52 14
Human Ehrlichial Infection, Human Monocytic Type 50
Ehrlichiosis Chafeensis 12
Hme 50

Classifications:



External Ids:

Disease Ontology 12 DOID:0050026

Summaries for Human Monocytic Ehrlichiosis

Disease Ontology : 12 An ehrlichiosis that results_in infection located in monocyte or located in macrophage, has material basis in Ehrlichia chaffeensis, which is transmitted_by black-legged tick (Ixodes scapularis), transmitted_by western black-legged tick (Ixodes pacificus) or transmitted_by castor bean tick (Ixodes ricinus,). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash.

MalaCards based summary : Human Monocytic Ehrlichiosis, also known as human ehrlichial infection, human monocytic type, is related to hereditary multiple exostoses and hereditary multiple osteochondromas. An important gene associated with Human Monocytic Ehrlichiosis is DNASE1L1 (Deoxyribonuclease 1 Like 1). Affiliated tissues include monocytes, testes and lymph node.

Related Diseases for Human Monocytic Ehrlichiosis

Diseases related to Human Monocytic Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
id Related Disease Score Top Affiliating Genes
1 hereditary multiple exostoses 11.3
2 hereditary multiple osteochondromas 10.8
3 hemimegalencephaly 10.8
4 ehrlichiosis 10.5
5 human granulocytic anaplasmosis 9.9
6 spotted fever 9.7
7 pancytopenia 9.7
8 diarrhea 9.7
9 appendicitis 9.7
10 macrophage activation syndrome 9.7
11 sudden sensorineural hearing loss 9.7
12 hemophagocytic lymphohistiocytosis 9.7
13 hepatitis 9.7
14 leukemia 9.7
15 rocky mountain spotted fever 9.7
16 sensorineural hearing loss 9.7
17 african tick-bite fever 6.4 APOPT1 CLPB DNASE1L1 ECHS1 GRPEL1 IL18R1

Graphical network of the top 20 diseases related to Human Monocytic Ehrlichiosis:



Diseases related to Human Monocytic Ehrlichiosis

Symptoms & Phenotypes for Human Monocytic Ehrlichiosis

Drugs & Therapeutics for Human Monocytic Ehrlichiosis

Search Clinical Trials , NIH Clinical Center for Human Monocytic Ehrlichiosis

Genetic Tests for Human Monocytic Ehrlichiosis

Anatomical Context for Human Monocytic Ehrlichiosis

MalaCards organs/tissues related to Human Monocytic Ehrlichiosis:

39
Monocytes, Testes, Lymph Node

Publications for Human Monocytic Ehrlichiosis

Articles related to Human Monocytic Ehrlichiosis:

(show all 34)
id Title Authors Year
1
Sudden sensorineural hearing loss in human monocytic ehrlichiosis. ( 28846788 )
2017
2
Successful Treatment of Human Monocytic Ehrlichiosis with Rifampin. ( 26918212 )
2016
3
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. ( 27575459 )
2016
4
Severe human monocytic ehrlichiosis presenting with altered mental status and seizures. ( 27758794 )
2016
5
The perils of country life: human monocytic ehrlichiosis. ( 25912197 )
2015
6
Macrophage activation syndrome secondary to human monocytic ehrlichiosis. ( 25332563 )
2014
7
A case of human monocytic ehrlichiosis in Serbia. ( 24684037 )
2014
8
Bayesian spatio-temporal analysis and geospatial risk factors of human monocytic ehrlichiosis. ( 24992684 )
2014
9
Multiorgan failure related to human monocytic ehrlichiosis. ( 23704428 )
2013
10
Ehrlichia chaffeensis human monocytic ehrlichiosis with pancytopenia. ( 22497260 )
2012
11
Fatal human monocytic ehrlichiosis: a case study. ( 21279705 )
2011
12
Results from a mathematical model for human monocytic ehrlichiosis. ( 20584161 )
2009
13
Diminished hematopoietic activity associated with alterations in innate and adaptive immunity in a mouse model of human monocytic ehrlichiosis. ( 19451243 )
2009
14
Current management of human granulocytic anaplasmosis, human monocytic ehrlichiosis and Ehrlichia ewingii ehrlichiosis. ( 19681699 )
2009
15
Acute infection with human monocytic ehrlichiosis: the tip of the iceberg? ( 18364633 )
2008
16
Human monocytic ehrlichiosis in children. ( 17529862 )
2007
17
Lymph node hemophagocytosis in rickettsial diseases: a pathogenetic role for CD8 T lymphocytes in human monocytic ehrlichiosis (HME)? ( 16859547 )
2006
18
Human monocytic ehrlichiosis and human granulocytic anaplasmosis in the United States, 2001-2002. ( 17114690 )
2006
19
Human monocytic ehrlichiosis in a renal transplant patient. ( 16857619 )
2006
20
Human monocytic ehrlichiosis. ( 15536115 )
2004
21
Ehrlichia chaffeensis infections among HIV-infected patients in a human monocytic ehrlichiosis-endemic area. ( 14519250 )
2003
22
Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection. ( 12817434 )
2003
23
Human monocytic ehrlichiosis presenting as acute appendicitis during pregnancy. ( 12384854 )
2002
24
Human monocytic ehrlichiosis: similar to Rocky Mountain spotted fever but different. ( 11905291 )
2002
25
Western blot analysis of sera reactive to human monocytic ehrlichiosis and human granulocytic ehrlichiosis agents. ( 11682518 )
2001
26
Human monocytic ehrlichiosis: an emerging pathogen in transplantation. ( 11435982 )
2001
27
Human monocytic ehrlichiosis: a potentially severe disease in children. ( 10922287 )
2000
28
Human monocytic ehrlichiosis in a child with leukemia. ( 10694014 )
2000
29
Outcome of diagnostic tests using samples from patients with culture-proven human monocytic ehrlichiosis: implications for surveillance. ( 10449489 )
1999
30
Human monocytic ehrlichiosis in a thirteen year old: a case report. ( 10478517 )
1999
31
Adaptation of the agent of the human monocyte ehrlichiosis (Ehrlichia chaffeensis) to HL60. ( 10348219 )
1999
32
Human monocytic ehrlichiosis in children. ( 9200384 )
1997
33
Human monocytic ehrlichiosis presenting as febrile diarrhea. ( 9412975 )
1997
34
Serologic diagnosis of human monocytic ehrlichiosis by immunoblot analysis. ( 8556515 )
1994

Variations for Human Monocytic Ehrlichiosis

Expression for Human Monocytic Ehrlichiosis

Search GEO for disease gene expression data for Human Monocytic Ehrlichiosis.

Pathways for Human Monocytic Ehrlichiosis

GO Terms for Human Monocytic Ehrlichiosis

Cellular components related to Human Monocytic Ehrlichiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.02 APOPT1 CLPB ECHS1 GRPEL1 PYCARD

Biological processes related to Human Monocytic Ehrlichiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.26 APOPT1 PYCARD
2 positive regulation of interferon-gamma production GO:0032729 9.16 IL18R1 PYCARD
3 positive regulation of release of cytochrome c from mitochondria GO:0090200 8.96 APOPT1 PYCARD
4 natural killer cell activation GO:0030101 8.62 IL18R1 IL21R

Sources for Human Monocytic Ehrlichiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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