MCID: HMN021
MIFTS: 41

Human T-Cell Leukemia Virus Type 1 malady

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Summaries for Human T-Cell Leukemia Virus Type 1

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33MalaCards
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MalaCards: Human T-Cell Leukemia Virus Type 1, also known as human t lymphotropic virus type 1, is related to leukemia and t-cell leukemia. An important gene associated with Human T-Cell Leukemia Virus Type 1 is CNTN2 (contactin 2 (axonal)), and among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and IL-17 Family Signaling Pathways. The compounds 12-o-tetradecanoylphorbol 13-acetate and leucine have been mentioned in the context of this disorder. Affiliated tissues include t cells, monocytes and liver.

Aliases & Classifications for Human T-Cell Leukemia Virus Type 1

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43NIH Rare Diseases
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Classifications:



Aliases & Descriptions:

human t-cell leukemia virus type 1 43
human t lymphotropic virus type 1 43
htlv-1 43


Related Diseases for Human T-Cell Leukemia Virus Type 1

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17GeneCards, 18GeneDecks
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Diseases in the Acute T Cell Leukemia family:

Adult T-Cell Leukemia T-Cell Leukemia
human t-cell leukemia virus type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Human T-Cell Leukemia Virus Type 1 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.4CNTN2, IFN1@, JUND, FUT7, HTLVR
2t-cell leukemia32.3RPL6, CREB3, CNTN2, HTLVR, FOSL1, JUND
3adult t-cell leukemia31.5CNTN2, JUND
4htlv-1 associated myelopathy10.8
5tropical spastic paraparesis10.7
6spastic paraparesis10.7
7spasticity10.7
8hiv-110.6
9hepatitis c10.5
10hepatitis10.5
11hepatitis c virus10.5
12strongyloidiasis10.4
13dermatitis10.4
14infective dermatitis associated with htlv-110.4
15borna disease10.4
16neuronitis10.4
17gastric lymphoma10.4
18hypercalcemia10.4
19graves' disease10.4
20t-cell large granular lymphocyte leukemia10.4
21arthritis10.4
22arthropathy10.4
23chronic lymphocytic leukemia10.4
24herpes simplex10.4
25hodgkin's lymphoma10.4
26lung cancer10.4
27retinoblastoma10.4
28rheumatoid arthritis10.4
29uveitis10.4
30htlv-1 associated myelopathy/tropical spastic paraparesis10.4
31large granular lymphocyte leukemia10.4
32pituitary tumors10.4
33endotheliitis10.4
34mycosis fungoides10.4
35retinal vasculitis10.4
36ataxia telangiectasia10.4
37diffuse large b-cell lymphoma10.4
38lymphoblastic leukemia10.4
39neurofibroma10.4
40vasculitis10.4
41necrobiotic xanthogranuloma10.4
42ataxia10.4
43neurologic diseases10.2
44multiple sclerosis10.1
45keratoconjunctivitis sicca10.1
46inclusion body myositis10.1
47cutaneous t cell lymphoma10.1
48keratoconjunctivitis10.1
49meningitis10.1
50myositis10.1

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 1:



Diseases related to human t-cell leukemia virus type 1

Symptoms for Human T-Cell Leukemia Virus Type 1

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Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 1

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Human T-Cell Leukemia Virus Type 1

Search NIH Clinical Center for Human T-Cell Leukemia Virus Type 1

Genetic Tests for Human T-Cell Leukemia Virus Type 1

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Anatomical Context for Human T-Cell Leukemia Virus Type 1

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33MalaCards
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MalaCards organs/tissues related to Human T-Cell Leukemia Virus Type 1:

33
T cells, Monocytes, Liver, B cells, Endothelial, Brain, Myeloid, Testes, Lung, Pituitary

Animal Models for Human T-Cell Leukemia Virus Type 1 or affiliated genes

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Publications for Human T-Cell Leukemia Virus Type 1

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52PubMed
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Articles related to Human T-Cell Leukemia Virus Type 1:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. (23577667)
2013
2
The cellular autophagy pathway modulates human T-cell leukemia virus type 1 replication. (23175371)
2013
3
HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-I_B activation and HTLV-1 replication. (24109220)
2013
4
Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth. (22010857)
2012
5
An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-I_B activation. (22258247)
2012
6
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling. (21315773)
2011
7
C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism. (19887455)
2010
8
The p13 protein of human T cell leukemia virus type 1 (HTLV-1) modulates mitochondrial membrane potential and calcium uptake. (20188695)
2010
9
Features of primary extranodal lymphoma in Kanagawa, a human T-cell leukemia virus type 1 nonendemic area in Japan. (18568429)
2009
10
PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients. (18830259)
2009
11
One-step, multiplex, real-time PCR assay with molecular beacon probes for simultaneous detection, differentiation, and quantification of human T-cell leukemia virus types 1, 2, and 3. (19213697)
2009
12
Human T-cell leukemia virus type 1 infection leads to arrest in the G1 phase of the cell cycle. (18596104)
2008
13
The role of WWP1-Gag interaction and Gag ubiquitination in assembly and release of human T-cell leukemia virus type 1. (17609263)
2007
14
Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax. (17507465)
2007
15
Human T-cell leukemia virus type 1 Tax enhances serum response factor DNA binding and alters site selection. (17376895)
2007
16
Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein. (17897946)
2007
17
Comparison of antigenic sites of the envelope glycoprotein of the Iranian isolate of human T-cell leukemia virus type 1 with different subtypes of the virus. (16883437)
2006
18
Modulation of nuclear factor-kappaB by human T cell leukemia virus type 1 Tax protein: implications for oncogenesis and inflammation. (16720895)
2006
19
Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III. (16716116)
2006
20
Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein. (16923801)
2006
21
TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. (16809310)
2006
22
Narrow substrate specificity and sensitivity toward ligand-binding site mutations of human T-cell Leukemia virus type 1 protease. (15102858)
2004
23
Expansion of human T-cell leukemia virus type 1 (HTLV-1) reservoir in orally infected rats: inverse correlation with HTLV-1-specific cellular immune response. (12584320)
2003
24
Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein. (11971966)
2002
25
The PPPY motif of human T-cell leukemia virus type 1 Gag protein is required early in the budding process. (12208980)
2002
26
5'-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo. (12186921)
2002
27
The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors. (11493471)
2001
28
Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure. (11559817)
2001
29
Human T-cell leukemia virus type 1 tax protein activates transcription through AP-1 site by inducing DNA binding activity in T cells. (11145887)
2001
30
Human T-cell leukemia virus type 1 (HTLV-1) infection of mice: proliferation of cell clones with integrated HTLV-1 provirus in lymphoid organs. (11287593)
2001
31
In vivo analysis of human T-cell leukemia virus type 1 reverse transcription accuracy. (11000222)
2000
32
Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activation. (9847380)
1999
33
Multiple functions for the basic amino acids of the human T-cell leukemia virus type 1 matrix protein in viral transmission. (9971764)
1999
34
Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein. (10329537)
1999
35
The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta. (9632633)
1998
36
Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. (9584203)
1998
37
Provirus load in patients with human T-cell leukemia virus type 1 uveitis correlates with precedent Graves' disease and disease activities. (9703358)
1998
38
Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter. (8995640)
1997
39
Among all human T-cell leukemia virus type 1 proteins, tax, polymerase, and envelope proteins are predicted as preferential targets for the HLA-A2-restricted cytotoxic T-cell response. (8763995)
1996
40
Complex formation between CREB and Tax enhances the binding affinity of CREB for the human T-cell leukemia virus type 1 21-base-pair repeats. (8649426)
1996
41
Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion. (8551623)
1996
42
Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in family members of adult T-cell leukemia (ATL) patients in non-ATL-endemic Hokkaido of Japan. (7669948)
1995
43
Characterization of a transcriptional attenuator within the 5' R region of the human T cell leukemia virus type 1. (8554910)
1995
44
Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in adult T-cell leukemia (ATL) in non-ATL-endemic Hokkaido of Japan. (7772727)
1994
45
A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins. (8350401)
1993
46
In vitro infection of human macrophages with human T-cell leukemia virus type 1. (8453107)
1993
47
Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. (8230424)
1993
48
Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and transport of unspliced RNAs. (2335818)
1990
49
SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. (2827008)
1988
50
Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. (3024966)
1986

Variations for Human T-Cell Leukemia Virus Type 1

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Expression for genes affiliated with Human T-Cell Leukemia Virus Type 1

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Human T-Cell Leukemia Virus Type 1

Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 1.

Pathways for genes affiliated with Human T-Cell Leukemia Virus Type 1

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50PathCards, 51PharmGKB, 54R&D Systems, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 55Reactome
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Pathways related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3FOSL1, JUND
2
Show member pathways
9.3FOSL1, JUND
3
Show member pathways
IL27-mediated signaling events38
9.3JUND, FOSL1
49.3JUND, FOSL1
5
Show member pathways
9.0ATF5, JUND, FOSL1
6
Show member pathways
Immune response MIF in innate immunity response60
9.0FOSL1, JUND, ATF5
79.0ATF5, FOSL1, JUND
8
Show member pathways
9.0ATF5, JUND, FOSL1
9
Show member pathways
9.0FOSL1, ATF5, JUND

Compounds for genes affiliated with Human T-Cell Leukemia Virus Type 1

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45Novoseek, 24HMDB
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Compounds related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
112-o-tetradecanoylphorbol 13-acetate459.1CNTN2, FOSL1, JUND
2leucine458.5JUND, FOSL1, CNTN2, CREB3
3cyclic amp45 248.9CRTC2, CREB3, CNTN2, FOSL1, JUND, ATF5

GO Terms for genes affiliated with Human T-Cell Leukemia Virus Type 1

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16Gene Ontology
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Biological processes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transpositionGO:0105299.9APOBEC3B, APOBEC3A
2learningGO:0076129.4CNTN2, FOSL1
3response to mechanical stimulusGO:0096129.3FOSL1, JUND
4regulation of transcription from RNA polymerase II promoterGO:0063578.9FOSL1, JUND, ATF5

Molecular functions related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1deoxycytidine deaminase activityGO:0478449.9APOBEC3B, APOBEC3A
2cAMP response element binding protein bindingGO:0081409.6CRTC2, CREB3
3RNA polymerase II regulatory region sequence-specific DNA bindingGO:0009779.4FOSL1, CREB3
4sequence-specific DNA binding transcription factor activityGO:0037008.8CREB3, FOSL1, JUND, ATF5

Products for genes affiliated with Human T-Cell Leukemia Virus Type 1

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Sources for Human T-Cell Leukemia Virus Type 1

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet