MCID: HMN021
MIFTS: 41

Human T-Cell Leukemia Virus Type 1 malady

Rare diseases, Immune diseases, Cancer diseases, Skin diseases, Blood diseases categories
Download this MalaCard

Summaries for Human T-Cell Leukemia Virus Type 1

About this section


Fully expand this MalaCard
MalaCards based summary: Human T-Cell Leukemia Virus Type 1, also known as human t lymphotropic virus type 1, is related to leukemia and adult t-cell leukemia. An important gene associated with Human T-Cell Leukemia Virus Type 1 is CNTN2 (contactin 2 (axonal)), and among its related pathways are IL-17 Family Signaling Pathways and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. The compounds 12-o-tetradecanoylphorbol 13-acetate and leucine have been mentioned in the context of this disorder. Affiliated tissues include t cells, liver and testes.

Aliases & Classifications for Human T-Cell Leukemia Virus Type 1

About this section

Human T-Cell Leukemia Virus Type 1, Aliases & Descriptions:

Name: Human T-Cell Leukemia Virus Type 1 42
Human T Lymphotropic Virus Type 1 42
 
Htlv-1 42


Classifications:



Related Diseases for Human T-Cell Leukemia Virus Type 1

About this section

Diseases in the Acute T Cell Leukemia family:

Adult T-Cell Leukemia T-Cell Leukemia
human t-cell leukemia virus type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic Leukemia, Acute Pre-B-Cell

Diseases related to Human T-Cell Leukemia Virus Type 1 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.0CNTN2, IFN1@, JUND, FUT7, HTLVR
2adult t-cell leukemia31.6CNTN2, JUND
3t-cell leukemia31.4RPL6, CREB3, CNTN2, HTLVR, FOSL1, JUND
4htlv-1 associated myelopathy10.8
5tropical spastic paraparesis10.7
6spastic paraparesis10.7
7spasticity10.7
8hiv-110.7
9hepatitis10.6
10hepatitis c10.6
11hepatitis c virus10.6
12strongyloidiasis10.5
13dermatitis10.4
14infective dermatitis associated with htlv-110.4
15arthritis10.4
16chronic lymphocytic leukemia10.4
17hodgkin's lymphoma10.4
18rheumatoid arthritis10.4
19borna disease10.4
20hypercalcemia10.4
21graves' disease10.4
22t-cell large granular lymphocyte leukemia10.4
23neuronitis10.4
24gastric lymphoma10.4
25arthropathy10.4
26herpes simplex10.4
27lung cancer10.4
28retinoblastoma10.4
29uveitis10.4
30glioblastoma10.4
31htlv-1 associated myelopathy/tropical spastic paraparesis10.4
32large granular lymphocyte leukemia10.4
33pituitary tumors10.4
34endotheliitis10.4
35acute lymphoblastic leukemia10.4
36ataxia telangiectasia10.4
37diffuse large b-cell lymphoma10.4
38mycosis fungoides10.4
39retinal vasculitis10.4
40lymphoblastic leukemia10.4
41neurofibroma10.4
42vasculitis10.4
43necrobiotic xanthogranuloma10.4
44ataxia10.4
45multiple sclerosis10.2
46neurologic diseases10.2
47peripheral t-cell lymphoma10.1
48keratoconjunctivitis sicca10.1
49inclusion body myositis10.1
50cutaneous t cell lymphoma10.1

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 1:



Diseases related to human t-cell leukemia virus type 1

Symptoms for Human T-Cell Leukemia Virus Type 1

About this section

Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 1

About this section

Drug clinical trials:

Search ClinicalTrials for Human T-Cell Leukemia Virus Type 1

Search NIH Clinical Center for Human T-Cell Leukemia Virus Type 1

Genetic Tests for Human T-Cell Leukemia Virus Type 1

About this section

Anatomical Context for Human T-Cell Leukemia Virus Type 1

About this section

MalaCards organs/tissues related to Human T-Cell Leukemia Virus Type 1:

32
T cells, Liver, Testes, Monocytes, B cells, Brain, Lung, Myeloid, Endothelial, Pituitary

Animal Models for Human T-Cell Leukemia Virus Type 1 or affiliated genes

About this section

Publications for Human T-Cell Leukemia Virus Type 1

About this section

Articles related to Human T-Cell Leukemia Virus Type 1:

(show top 50)    (show all 413)
idTitleAuthorsYear
1
LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. (23577667)
2013
2
The cellular autophagy pathway modulates human T-cell leukemia virus type 1 replication. (23175371)
2013
3
HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-I_B activation and HTLV-1 replication. (24109220)
2013
4
Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth. (22010857)
2012
5
An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-I_B activation. (22258247)
2012
6
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling. (21315773)
2011
7
C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism. (19887455)
2010
8
The p13 protein of human T cell leukemia virus type 1 (HTLV-1) modulates mitochondrial membrane potential and calcium uptake. (20188695)
2010
9
Features of primary extranodal lymphoma in Kanagawa, a human T-cell leukemia virus type 1 nonendemic area in Japan. (18568429)
2009
10
PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients. (18830259)
2009
11
One-step, multiplex, real-time PCR assay with molecular beacon probes for simultaneous detection, differentiation, and quantification of human T-cell leukemia virus types 1, 2, and 3. (19213697)
2009
12
The role of WWP1-Gag interaction and Gag ubiquitination in assembly and release of human T-cell leukemia virus type 1. (17609263)
2007
13
Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax. (17507465)
2007
14
Human T-cell leukemia virus type 1 Tax enhances serum response factor DNA binding and alters site selection. (17376895)
2007
15
Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein. (17897946)
2007
16
Comparison of antigenic sites of the envelope glycoprotein of the Iranian isolate of human T-cell leukemia virus type 1 with different subtypes of the virus. (16883437)
2006
17
Modulation of nuclear factor-kappaB by human T cell leukemia virus type 1 Tax protein: implications for oncogenesis and inflammation. (16720895)
2006
18
Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III. (16716116)
2006
19
Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein. (16923801)
2006
20
TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. (16809310)
2006
21
Narrow substrate specificity and sensitivity toward ligand-binding site mutations of human T-cell Leukemia virus type 1 protease. (15102858)
2004
22
Expansion of human T-cell leukemia virus type 1 (HTLV-1) reservoir in orally infected rats: inverse correlation with HTLV-1-specific cellular immune response. (12584320)
2003
23
Lamivudine resistance in human T-cell leukemia virus type 1 may be due to a polymorphism at codon 118 (V-->I) of the reverse transcriptase. (12709359)
2003
24
Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein. (11971966)
2002
25
The PPPY motif of human T-cell leukemia virus type 1 Gag protein is required early in the budding process. (12208980)
2002
26
5'-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo. (12186921)
2002
27
The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors. (11493471)
2001
28
Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure. (11559817)
2001
29
Human T-cell leukemia virus type 1 tax protein activates transcription through AP-1 site by inducing DNA binding activity in T cells. (11145887)
2001
30
Human T-cell leukemia virus type 1 (HTLV-1) infection of mice: proliferation of cell clones with integrated HTLV-1 provirus in lymphoid organs. (11287593)
2001
31
In vivo analysis of human T-cell leukemia virus type 1 reverse transcription accuracy. (11000222)
2000
32
Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activation. (9847380)
1999
33
Multiple functions for the basic amino acids of the human T-cell leukemia virus type 1 matrix protein in viral transmission. (9971764)
1999
34
Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein. (10329537)
1999
35
The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta. (9632633)
1998
36
Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. (9584203)
1998
37
Provirus load in patients with human T-cell leukemia virus type 1 uveitis correlates with precedent Graves' disease and disease activities. (9703358)
1998
38
Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter. (8995640)
1997
39
Among all human T-cell leukemia virus type 1 proteins, tax, polymerase, and envelope proteins are predicted as preferential targets for the HLA-A2-restricted cytotoxic T-cell response. (8763995)
1996
40
Complex formation between CREB and Tax enhances the binding affinity of CREB for the human T-cell leukemia virus type 1 21-base-pair repeats. (8649426)
1996
41
Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion. (8551623)
1996
42
Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in family members of adult T-cell leukemia (ATL) patients in non-ATL-endemic Hokkaido of Japan. (7669948)
1995
43
Characterization of a transcriptional attenuator within the 5' R region of the human T cell leukemia virus type 1. (8554910)
1995
44
Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in adult T-cell leukemia (ATL) in non-ATL-endemic Hokkaido of Japan. (7772727)
1994
45
A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins. (8350401)
1993
46
In vitro infection of human macrophages with human T-cell leukemia virus type 1. (8453107)
1993
47
Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. (8230424)
1993
48
Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and transport of unspliced RNAs. (2335818)
1990
49
SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. (2827008)
1988
50
Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. (3024966)
1986

Variations for Human T-Cell Leukemia Virus Type 1

About this section

Expression for genes affiliated with Human T-Cell Leukemia Virus Type 1

About this section
Expression patterns in normal tissues for genes affiliated with Human T-Cell Leukemia Virus Type 1

Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 1.

Pathways for genes affiliated with Human T-Cell Leukemia Virus Type 1

About this section

Pathways related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3FOSL1, JUND
29.3FOSL1, JUND
39.3FOSL1, JUND
4
Show member pathways
IL27-mediated signaling events37
9.3JUND, FOSL1
5
Show member pathways
Immune response MIF in innate immunity response60
9.0ATF5, JUND, FOSL1
6
Show member pathways
9.0FOSL1, JUND, ATF5
79.0FOSL1, JUND, ATF5
8
Show member pathways
9.0FOSL1, JUND, ATF5
9
Show member pathways
9.0ATF5, JUND, FOSL1

Compounds for genes affiliated with Human T-Cell Leukemia Virus Type 1

About this section
Sources:
44Novoseek, 24HMDB
See all sources

Compounds related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
112-o-tetradecanoylphorbol 13-acetate449.1CNTN2, FOSL1, JUND
2leucine448.5JUND, FOSL1, CNTN2, CREB3
3cyclic amp44 248.9CRTC2, CREB3, CNTN2, FOSL1, JUND, ATF5

GO Terms for genes affiliated with Human T-Cell Leukemia Virus Type 1

About this section

Biological processes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transpositionGO:0105299.9APOBEC3B, APOBEC3A
2learningGO:0076129.4CNTN2, FOSL1
3response to mechanical stimulusGO:0096129.3FOSL1, JUND
4regulation of transcription from RNA polymerase II promoterGO:0063578.9FOSL1, JUND, ATF5

Molecular functions related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1deoxycytidine deaminase activityGO:0478449.9APOBEC3B, APOBEC3A
2cAMP response element binding protein bindingGO:0081409.6CRTC2, CREB3
3RNA polymerase II regulatory region sequence-specific DNA bindingGO:0009779.4FOSL1, CREB3
4sequence-specific DNA binding transcription factor activityGO:0037008.8CREB3, FOSL1, JUND, ATF5

Products for genes affiliated with Human T-Cell Leukemia Virus Type 1

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Human T-Cell Leukemia Virus Type 1

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet