MCID: HMN021
MIFTS: 30

Human T-Cell Leukemia Virus Type 1 malady

Immune category

Summaries for Human T-Cell Leukemia Virus Type 1

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MalaCards: Human T-Cell Leukemia Virus Type 1, also known as human t lymphotropic virus type 1, is related to t-cell leukemia and adult t-cell leukemia. An important gene associated with Human T-Cell Leukemia Virus Type 1 is CNTN2 (contactin 2 (axonal)), and among its related pathways are Rho Family GTPases and Akt Signaling. The compounds cyclic amp and 12-o-tetradecanoylphorbol 13-acetate have been mentioned in the context of this disorder. Affiliated tissues include monocytes and t cells.

Aliases & Classifications for Human T-Cell Leukemia Virus Type 1

Sources:
43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

human t-cell leukemia virus type 1 43
human t lymphotropic virus type 1 43
htlv-1 43


Related Diseases for Human T-Cell Leukemia Virus Type 1

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17GeneCards, 18GeneDecks
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Diseases related to Human T-Cell Leukemia Virus Type 1 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1t-cell leukemia32.5FOSL1, CREB3, FUT7, HTLVR, JUND, RPL6
2adult t-cell leukemia31.4CNTN2, JUND
3hepatitis b30.5IFN1@
4leukemia/lymphoma, t-cell10.8
5tropical spastic paraparesis10.7
6spastic paraparesis10.7
7adult lymphoma10.6
8leukemia, t-cell, chronic10.6
9lymphoid leukemia10.5
10hepatitis c10.5
11gastric lymphoma10.5
12natural killer cell leukemia10.5
13hepatitis c virus10.5
14strongyloidiasis10.4
15diphtheria10.4
16borna disease10.4
17hepatitis d10.4
18hypercalcemia10.4
19t-cell large granular lymphocyte leukemia10.4
20graves' disease10.4
21arthritis10.4
22arthropathy10.4
23uveitis10.4
24htlv-1 associated myelopathy/tropical spastic paraparesis10.4
25large granular lymphocyte leukemia10.4
26hepatitis b virus infection10.4
27ataxia telangiectasia10.4
28mycosis fungoides10.4
29retinal vasculitis10.4
30vasculitis10.4
31acute lymphoblastic leukemia, childhood10.4
32necrobiotic xanthogranuloma10.4
33ataxia10.4
34lymphoma, diffuse large cell10.4
35n syndrome10.1
36keratoconjunctivitis sicca10.0
37inclusion body myositis10.0
38polymyositis10.0
39htlv-1 associated myelopathy10.0
40infective dermatitis associated with htlv-110.0
41leukemia10.0BCL3, FUT7, CNTN2, CD7, CREB1, HTLVR
42rheumatoid arthritis10.0CCL18, CD7, CNTN2, CREB1, HTLVR, JUND
43psoriasis10.0APOBEC3A, CCL18, IFN1@, CREB1
44breast cancer10.0FOSL1, JUND, BCL3
45burkitt's lymphoma10.0FUT7, CREB1, CNTN2, BCL3, JUND, CD7
46glioblastoma multiforme10.0CREB1
47myeloma10.0CNTN2
48norwegian scabies9.9
49pulmonary tuberculosis9.9
50paranasal sinus lymphoma9.9

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 1:



Diseases related to human t-cell leukemia virus type 1

Clinical Features for Human T-Cell Leukemia Virus Type 1

Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 1

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Human T-Cell Leukemia Virus Type 1

Drug clinical trials:

Search ClinicalTrials for Human T-Cell Leukemia Virus Type 1

Search NIH Clinical Center for Human T-Cell Leukemia Virus Type 1

Search CenterWatch for Human T-Cell Leukemia Virus Type 1

Genetic Tests for Human T-Cell Leukemia Virus Type 1

Anatomical Context for Human T-Cell Leukemia Virus Type 1

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33MalaCards
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MalaCards organs/tissues related to Human T-Cell Leukemia Virus Type 1:

33
Monocytes, T cells

Animal Models for Human T-Cell Leukemia Virus Type 1 or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Human T-Cell Leukemia Virus Type 1

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51PubMed
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Articles related to Human T-Cell Leukemia Virus Type 1:

idTitleAuthorsYear
1
Retraction. Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines. Journal of Virology, Volume 79, no. 3, p. 1367-78, 2005. (21228250)
2011
2
Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1. (9376596)
1997
3
Transactivation of the interleukin-1alpha promoter by human T-cell leukemia virus type I and type II Tax proteins. (8605359)
1996
4
Long-term noncytopathic productive infection of the human monocytic leukemia cell line THP-1 by human immunodeficiency virus type 1 (HIV-1IIIB). (8460491)
1993

Genetic Variations for Human T-Cell Leukemia Virus Type 1

Expression for genes affiliated with Human T-Cell Leukemia Virus Type 1

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Human T-Cell Leukemia Virus Type 1

Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 1.

Pathways for genes affiliated with Human T-Cell Leukemia Virus Type 1

Sources:
52QIAGEN, 53R&D Systems, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 54Reactome
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Pathways related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8FOSL1, JUND, CCL18, CREB3, CREB1, ATF5
2
Hide members
10.8CREB1, JUND, CCL18, CREB3, FOSL1
3
Hide members
10.8JUND, FOXO4, CREB1, BCL3, FOSL1
410.7RANBP1, FOSL1, CREB1, CRTC2
510.7BCL3, CREB1, CREB3
610.7FOSL1, JUND, CREB1
710.7FOSL1, CREB1, JUND
8
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.7JUND, FOSL1, CREB1
910.7JUND, FOSL1, CREB1
10
Hide members
10.7ATF5, JUND, FOSL1
1110.7FOSL1, JUND, ATF5
12
Hide members
10.7JUND, FOSL1, ATF5
1310.6CREB1, CREB3
1410.6CREB1, FOXO4

Compounds for genes affiliated with Human T-Cell Leukemia Virus Type 1

Sources:
45Novoseek, 24HMDB
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Compounds related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclic amp45 2411.8CNTN2, JUND, FOSL1, CRTC2, CREB3, CREB1
212-o-tetradecanoylphorbol 13-acetate4510.7JUND, FOSL1, CNTN2, CREB1
3leucine4510.5FOSL1, CREB3, CREB1, CNTN2, JUND

GO Terms for genes affiliated with Human T-Cell Leukemia Virus Type 1

Sources:
16Gene Ontology
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Cellular components related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.1BCL3, APOBEC3B, APOBEC3A, FOSL1, FOXO4, CRTC2

Biological processes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.7CREB3, FOSL1, CCL18
2negative regulation of transpositionGO:01052910.3APOBEC3A, APOBEC3B

Molecular functions related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370010.8BCL3, JUND, FOSL1, FOXO4, CREB3, CREB1
2cAMP response element binding protein bindingGO:00814010.6CREB3, CRTC2
3deoxycytidine deaminase activityGO:04784410.3APOBEC3A, APOBEC3B

Products for genes affiliated with Human T-Cell Leukemia Virus Type 1

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Sources for Human T-Cell Leukemia Virus Type 1

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet