MCID: HMN021
MIFTS: 27

Human T-Cell Leukemia Virus Type 1 malady

Immune diseases category

Summaries for Human T-Cell Leukemia Virus Type 1

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MalaCards: Human T-Cell Leukemia Virus Type 1, also known as human t lymphotropic virus type 1, is related to t-cell leukemia and leukemia. An important gene associated with Human T-Cell Leukemia Virus Type 1 is CNTN2 (contactin 2 (axonal)), and among its related pathways are Rho Family GTPases and Akt Signaling. The compounds cyclic amp and 12-o-tetradecanoylphorbol 13-acetate have been mentioned in the context of this disorder. Affiliated tissues include t cells.

Aliases & Classifications for Human T-Cell Leukemia Virus Type 1

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42NIH Rare Diseases
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Classifications:

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Anatomical: Immune diseases


Aliases & Descriptions:

human t-cell leukemia virus type 1 42
human t lymphotropic virus type 1 42
htlv-1 42


Related Diseases for Human T-Cell Leukemia Virus Type 1

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17GeneCards, 18GeneDecks
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Diseases in the Acute T Cell Leukemia family:

Adult T-Cell Leukemia T-Cell Leukemia
Leukemia, B-Cell, Chronic Leukemia, T-Cell, Chronic
human t-cell leukemia virus type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3

Diseases related to Human T-Cell Leukemia Virus Type 1 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1t-cell leukemia32.5FOSL1, CREB3, FUT7, HTLVR, JUND, RPL6
2leukemia32.5BCL3, FUT7, CNTN2, CD7, CREB1, HTLVR
3adult t-cell leukemia31.4CNTN2, JUND
4rheumatoid arthritis30.5CCL18, CD7, CNTN2, CREB1, HTLVR, JUND
5tropical spastic paraparesis10.7
6adult lymphoma10.6
7lymphoid leukemia10.5
8hepatitis c10.5
9gastric lymphoma10.5
10natural killer cell leukemia10.5
11cell type cancer10.5
12hepatitis10.5
13hodgkin's lymphoma10.5
14monocytic leukemia10.5
15strongyloidiasis10.4
16borna disease10.4
17neuronitis10.4
18hypercalcemia10.4
19t-cell large granular lymphocyte leukemia10.4
20graves' disease10.4
21arthritis10.4
22arthropathy10.4
23chronic lymphocytic leukemia10.4
24herpes simplex10.4
25lung cancer10.4
26myeloid leukemia10.4
27retinoblastoma10.4
28uveitis10.4
29htlv-1 associated myelopathy/tropical spastic paraparesis10.4
30dermatitis10.4
31ataxia telangiectasia10.4
32mycosis fungoides10.4
33diffuse large b-cell lymphoma10.4
34retinal vasculitis10.4
35childhood leukemia10.4
36lymphoblastic leukemia10.4
37neurofibroma10.4
38vasculitis10.4
39neurologic diseases10.2
40multiple sclerosis10.1
41keratoconjunctivitis sicca10.0
42inclusion body myositis10.0
43cutaneous t cell lymphoma10.0
44keratoconjunctivitis10.0
45meningitis10.0
46myositis10.0
47htlv-1 associated myelopathy10.0
48infective dermatitis associated with htlv-110.0
49psoriasis10.0APOBEC3A, CCL18, IFN1@, CREB1
50breast cancer10.0FOSL1, JUND, BCL3

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 1:



Diseases related to human t-cell leukemia virus type 1

Clinical Features for Human T-Cell Leukemia Virus Type 1

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Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 1

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Human T-Cell Leukemia Virus Type 1

Drug clinical trials:

Search ClinicalTrials for Human T-Cell Leukemia Virus Type 1

Search NIH Clinical Center for Human T-Cell Leukemia Virus Type 1

Search CenterWatch for Human T-Cell Leukemia Virus Type 1

Genetic Tests for Human T-Cell Leukemia Virus Type 1

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Anatomical Context for Human T-Cell Leukemia Virus Type 1

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32MalaCards
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MalaCards organs/tissues related to Human T-Cell Leukemia Virus Type 1:

32
T cells

Animal Models for Human T-Cell Leukemia Virus Type 1 or affiliated genes

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Publications for Human T-Cell Leukemia Virus Type 1

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Genetic Variations for Human T-Cell Leukemia Virus Type 1

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Expression for genes affiliated with Human T-Cell Leukemia Virus Type 1

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Human T-Cell Leukemia Virus Type 1

Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 1.

Pathways for genes affiliated with Human T-Cell Leukemia Virus Type 1

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51QIAGEN, 52R&D Systems, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8FOSL1, JUND, CCL18, CREB3, CREB1, ATF5
2
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10.8CREB1, JUND, CCL18, CREB3, FOSL1
3
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10.8JUND, FOXO4, CREB1, BCL3, FOSL1
410.7RANBP1, FOSL1, CREB1, CRTC2
510.7BCL3, CREB1, CREB3
610.7FOSL1, JUND, CREB1
710.7FOSL1, CREB1, JUND
8
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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10.7JUND, FOSL1, CREB1
910.7JUND, FOSL1, CREB1
10
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10.7ATF5, JUND, FOSL1
1110.7FOSL1, JUND, ATF5
12
Hide members
10.7JUND, FOSL1, ATF5
1310.6CREB1, CREB3
1410.6CREB1, FOXO4

Compounds for genes affiliated with Human T-Cell Leukemia Virus Type 1

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44Novoseek, 24HMDB
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Compounds related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclic amp44 2411.8CNTN2, JUND, FOSL1, CRTC2, CREB3, CREB1
212-o-tetradecanoylphorbol 13-acetate4410.7JUND, FOSL1, CNTN2, CREB1
3leucine4410.5FOSL1, CREB3, CREB1, CNTN2, JUND

GO Terms for genes affiliated with Human T-Cell Leukemia Virus Type 1

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16Gene Ontology
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Cellular components related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.1BCL3, APOBEC3B, APOBEC3A, FOSL1, FOXO4, CRTC2

Biological processes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.7CREB3, FOSL1, CCL18
2negative regulation of transpositionGO:01052910.3APOBEC3A, APOBEC3B

Molecular functions related to Human T-Cell Leukemia Virus Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370010.8BCL3, JUND, FOSL1, FOXO4, CREB3, CREB1
2cAMP response element binding protein bindingGO:00814010.6CREB3, CRTC2
3deoxycytidine deaminase activityGO:04784410.3APOBEC3A, APOBEC3B

Products for genes affiliated with Human T-Cell Leukemia Virus Type 1

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Sources for Human T-Cell Leukemia Virus Type 1

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet