MCID: HMR009
MIFTS: 34

Humoral Hypercalcemia of Malignancy malady

Summaries for Humoral Hypercalcemia of Malignancy

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MalaCards: Humoral Hypercalcemia of Malignancy is related to hypercalcemia and adenocarcinoma. An important gene associated with Humoral Hypercalcemia of Malignancy is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Prostacyclin signalling through prostacyclin receptor and Nuclear receptors in lipid metabolism and toxicity. The compounds pge2 and forskolin have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Humoral Hypercalcemia of Malignancy

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46OMIM
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Aliases & Descriptions:

humoral hypercalcemia of malignancy 46


Related Diseases for Humoral Hypercalcemia of Malignancy

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17GeneCards, 18GeneDecks
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Diseases related to Humoral Hypercalcemia of Malignancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia31.8ADCY10, BGLAP, CASR, TNFRSF11A, TNFSF11, NR1I3
2adenocarcinoma30.9CASR, TNFSF11, CYP27B1, PTHLH, ADCY10
3pancreatitis30.9CASR
4hyperparathyroidism30.7CASR, TNFSF11, NR1I3, CYP27B1, FGF23, PTHLH
5primary hyperparathyroidism30.6BGLAP, CASR, NR1I3, CYP27B1, FGF23, PTH1R
6sarcoma30.5ADCY10
7bone carcinoma30.5PTHLH, TNFSF11, TNFRSF11A, BGLAP
8breast cancer30.4CASR, TNFRSF11A, TNFSF11, NR1I3, CYP27B1, PTH1R
9hypoparathyroidism30.2BGLAP, CASR, NR1I3, FGF23, PTH1R, PTHLH
10squamous cell carcinoma10.7
11parathyroid carcinoma10.6
12pancreatic cancer10.5
13leydig cell tumor10.4
14malignant leydig cell tumor10.4
15anal gland adenocarcinoma10.3
16apocrine adenocarcinoma10.3
17neuroendocrine tumor10.3
18thyroiditis10.3
19transitional cell carcinoma10.3
20esophagus small cell carcinoma10.2
21adenosquamous pancreas carcinoma10.2
22small cell carcinoma10.2
23lymphosarcoma10.2
24adult lymphoma10.2
25adenosquamous carcinoma10.2
26large cell carcinoma10.2
27cholangiocarcinoma10.2
28cystic teratoma10.2
29epidermolysis bullosa10.2
30epithelioid sarcoma10.2
31esophagus squamous cell carcinoma10.2
32leiomyosarcoma10.2
33lung large cell carcinoma10.2
34malignant teratoma10.2
35mature teratoma10.2
36renal cell carcinoma10.2
37severe combined immunodeficiency10.2
38skin squamous cell carcinoma10.2
39ureter transitional cell carcinoma10.2
40adult t-cell leukemia10.0PTHLH
41paget's disease of bone10.0TNFRSF11A
42mccune albright syndrome10.0FGF23
43ollier disease10.0PTHLH
44cholesteatoma10.0TNFSF11
45peritonitis10.0TNF
46osteosclerosis10.0TNFSF11
47chondroblastoma10.0PTHLH
48vascular disease10.0TNF
49gingivitis10.0TNFSF11
50ankylosing spondylitis10.0TNF

Graphical network of the top 20 diseases related to Humoral Hypercalcemia of Malignancy:



Diseases related to humoral hypercalcemia of malignancy

Clinical Features for Humoral Hypercalcemia of Malignancy

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Drugs & Therapeutics for Humoral Hypercalcemia of Malignancy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Humoral Hypercalcemia of Malignancy

Drug clinical trials:

Search ClinicalTrials for Humoral Hypercalcemia of Malignancy

Search NIH Clinical Center for Humoral Hypercalcemia of Malignancy

Search CenterWatch for Humoral Hypercalcemia of Malignancy

Genetic Tests for Humoral Hypercalcemia of Malignancy

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Anatomical Context for Humoral Hypercalcemia of Malignancy

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Animal Models for Humoral Hypercalcemia of Malignancy or affiliated genes

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36MGI
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Publications for Humoral Hypercalcemia of Malignancy

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Genetic Variations for Humoral Hypercalcemia of Malignancy

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Expression for genes affiliated with Humoral Hypercalcemia of Malignancy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Humoral Hypercalcemia of Malignancy

Search GEO for disease gene expression data for Humoral Hypercalcemia of Malignancy.

Pathways for genes affiliated with Humoral Hypercalcemia of Malignancy

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53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 29KEGG, 55SinoBiological, 52R&D Systems, 4Cell Signaling Technology
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Pathways related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9PTH1R, PTHLH
29.8CYP27B1, NR1I3
39.6TNFSF11, TNFRSF11A
49.2PTH1R, FGF23, TNFSF11
5
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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8.8PTHLH, BGLAP, PTH1R, TNFSF11
6
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8.8TNF, TNFRSF11A, TNFSF11
78.8TNFRSF11A, TNF, TNFSF11
8
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8.8TNFRSF11A, TNFSF11, TNF
9
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8.8TNFRSF11A, TNF, TNFSF11
10
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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8.8TNFSF11, TNFRSF11A, TNF
118.8TNFSF11, TNFRSF11A, TNF
128.8TNFRSF11A, TNFSF11, TNF
138.8TNF, TNFSF11, TNFRSF11A
14
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8.4TNFSF11, FGF23, TNFRSF11A, TNF
15
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8.4FGF23, TNF, TNFSF11, TNFRSF11A
16
Transcription Role of VDR in regulation of genes involved in osteoporosis
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7.6TNF, PTH1R, CYP27B1, TNFSF11, TNFRSF11A, BGLAP

Compounds for genes affiliated with Humoral Hypercalcemia of Malignancy

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1pge24410.6PTH1R
2forskolin44 49 1112.6PTH1R
3estradiol44 11 2412.2PTHLH, NR1I3
4cycloheximide4410.1ADCY10
5calcifediol5910.1CYP27B1, NR1I3
6clodronate44 49 1112.1PTHLH, TNFSF11
7alfacalcidol44 59 1111.7NR1I3, CYP27B1, BGLAP
8calcipotriol44 59 28 1112.7NR1I3, BGLAP, CYP27B1
922-oxacalcitriol449.6CASR, PTHLH, BGLAP
10adenosine 3,5-cyclic monophosphorothioate449.6PTHLH, ADCY10
11tartrate449.5BGLAP, PTHLH, TNFSF11
12sevelamer449.5CASR, BGLAP, FGF23
13teriparatide44 1110.5TNFSF11, PTH1R, BGLAP
14ccl444 2810.5PTH1R, PTHLH, TNFSF11
15zoledronic acid449.5TNFSF11, BGLAP, PTHLH
16alendronate44 49 1111.5TNFSF11, PTHLH, BGLAP
1724,25-dihydroxyvitamin d3449.4CYP27B1, ADCY10, BGLAP
18eb 108944 5910.4CYP27B1, PTHLH, BGLAP, NR1I3
19strontium ranelate449.4TNFSF11, CASR
20raloxifene44 28 49 1112.3BGLAP, TNFSF11, TNFRSF11A
21denosumab44 1110.3TNFRSF11A, TNFSF11
22octreotide44 59 28 1112.3FGF23, PTHLH, ADCY10
23ribonucleic acid449.3CASR, PTHLH, PTH1R, NR1I3
24amrinone44 1110.2TNF, ADCY10
25pamidronate44 49 1111.1CASR, PTHLH, TNFSF11, BGLAP
26inositol 1,4,5 trisphosphate449.0ADCY10, NR1I3, PTH1R, CASR
27hydrogen44 249.9CASR, TNFSF11, PTHLH, PTH1R, CYP27B1
28ns 39844 599.9TNF, TNFSF11, BGLAP
29infliximab44 49 1110.8TNFSF11, TNF, BGLAP
30steroid448.7CYP27B1, PTHLH, PTH1R, NR1I3, TNFSF11
31testosterone44 59 11 2411.7BGLAP, PTHLH, NR1I3, CYP27B1, TNFSF11
32creatinine448.6BGLAP, CASR, TNFSF11, FGF23, PTHLH
33dexamethasone44 49 28 1111.5ADCY10, BGLAP, TNFSF11, PTH1R, NR1I3
3425-hydroxyvitamin d448.4PTHLH, BGLAP, CASR, TNFSF11, FGF23, CYP27B1
35hydroxyapatite448.4PTHLH, BGLAP, CASR, TNFRSF11A, TNFSF11, FGF23
36prostaglandin448.3TNF, PTHLH, ADCY10, TNFRSF11A, TNFSF11
37arginine448.2FGF23, BGLAP, NR1I3, PTHLH, ADCY10, CASR
38retinoic acid44 249.2NR1I3, PTH1R, CYP27B1, PTHLH, TNF, BGLAP
39oxygen44 249.2PTHLH, TNFRSF11A, CYP27B1, NR1I3, TNFSF11, TNF
40cyclosporin a44 28 5910.1NR1I3, TNF, TNFSF11, CASR, BGLAP
41nitric oxide44 11 2410.1PTHLH, PTH1R, TNF, TNFSF11, TNFRSF11A, CASR
42tyrosine448.1TNFSF11, NR1I3, CYP27B1, TNFRSF11A, FGF23, PTHLH
43cyclic amp44 249.0NR1I3, CASR, TNFSF11, CYP27B1, ADCY10, PTHLH
44lipid447.9TNFSF11, TNFRSF11A, PTHLH, TNF, CYP27B1, NR1I3
45phosphorus447.7FGF23, PTH1R, PTHLH, CYP27B1, BGLAP, CASR
46vitamin d447.7TNFSF11, CASR, BGLAP, NR1I3, CYP27B1, FGF23
471,25 dihydroxy vitamin d3447.4BGLAP, CASR, TNFRSF11A, TNFSF11, NR1I3, CYP27B1
48serine446.8PTHLH, PTH1R, FGF23, NR1I3, TNF, TNFRSF11A
49calcium44 49 11 249.7TNFRSF11A, CASR, BGLAP, ADCY10, PTHLH, PTH1R
50calcitriol44 59 11 249.6TNF, BGLAP, CASR, TNFRSF11A, PTHLH, PTH1R

GO Terms for genes affiliated with Humoral Hypercalcemia of Malignancy

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16Gene Ontology
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Cellular components related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.9PTHLH, FGF23, TNF, TNFSF11, BGLAP

Biological processes related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:01098010.1FGF23, CYP27B1
2vitamin D catabolic processGO:04236910.1FGF23, CYP27B1
3positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.0TNFRSF11A, TNFSF11
4TNFSF11-mediated signaling pathwayGO:0718479.9TNFRSF11A, TNFSF11
5positive regulation of fever generation by positive regulation of prostaglandin secretionGO:0718129.9TNFRSF11A, TNFSF11
6response to vitamin DGO:0332809.9CYP27B1, BGLAP
7mammary gland alveolus developmentGO:0607499.8TNFSF11, TNFRSF11A
8regulation of bone mineralizationGO:0305009.8BGLAP, CYP27B1
9monocyte chemotaxisGO:0025489.8TNFRSF11A, TNFSF11
10calcium ion homeostasisGO:0550749.7CYP27B1, TNFSF11
11osteoblast developmentGO:0020769.7PTHLH, PTH1R, BGLAP
12bone mineralizationGO:0302829.7PTH1R, CYP27B1, BGLAP
13bone resorptionGO:0454539.6TNFSF11, PTH1R
14skeletal system developmentGO:0015019.6BGLAP, PTH1R, PTHLH
15ossificationGO:0015039.5CASR, TNFRSF11A, TNFSF11
16positive regulation of osteoclast differentiationGO:0456729.3TNFSF11, TNF
17negative regulation of osteoblast differentiationGO:0456689.2FGF23, TNF
18osteoclast differentiationGO:0303169.1TNF, TNFSF11, TNFRSF11A
19tumor necrosis factor-mediated signaling pathwayGO:0332099.1TNFRSF11A, TNFSF11, TNF
20positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1TNF, TNFSF11, TNFRSF11A
21positive regulation of NF-kappaB transcription factor activityGO:0510929.1TNF, TNFSF11, TNFRSF11A
22response to activityGO:0148239.0TNF, BGLAP
23negative regulation of cell proliferationGO:0082859.0TNF, CYP27B1, PTH1R, PTHLH
24positive regulation of JUN kinase activityGO:0435079.0TNF, TNFRSF11A
25positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431238.9TNF, TNFSF11, TNFRSF11A

Molecular functions related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.1TNF, TNFSF11

Products for genes affiliated with Humoral Hypercalcemia of Malignancy

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Sources for Humoral Hypercalcemia of Malignancy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet