MCID: HMR009
MIFTS: 47

Humoral Hypercalcemia of Malignancy malady

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Summaries for Humoral Hypercalcemia of Malignancy

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MalaCards based summary: Humoral Hypercalcemia of Malignancy is related to leydig cell tumor and adenocarcinoma. An important gene associated with Humoral Hypercalcemia of Malignancy is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Nuclear receptors in lipid metabolism and toxicity and FGF signaling pathway. The compounds calcifediol and alfacalcidol have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and thyroid, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Classifications for Humoral Hypercalcemia of Malignancy

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Humoral Hypercalcemia of Malignancy, Aliases & Descriptions:

Name: Humoral Hypercalcemia of Malignancy 46 62


Related Diseases for Humoral Hypercalcemia of Malignancy

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Diseases related to Humoral Hypercalcemia of Malignancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1leydig cell tumor30.8ADCY10, PTHLH
2adenocarcinoma30.3ADCY10, CASR, PTHLH, TNFSF11, CYP27B1
3primary hyperparathyroidism30.1PTHLH, CASR, NR1I3, FGF23, PTH1R, BGLAP
4hypercalcemia30.1NR1I3, FGF23, CASR, ADCY10, PTHLH, PTH1R
5hypoparathyroidism29.9FGF23, NR1I3, CASR, BGLAP, PTH1R, PTHLH
6hyperparathyroidism29.5FGF23, NR1I3, CASR, CYP27B1, BGLAP, TNFSF11
7breast cancer29.2PTH1R, CYP27B1, TNFRSF11A, TNFSF11, PTHLH, ADCY10
8pancreatitis10.6
9pancreatic cancer10.6
10ollier disease10.5PTHLH
11mccune albright syndrome10.5FGF23
12paget's disease of bone10.5TNFRSF11A
13neuroendocrine tumor10.4
14sarcoma10.4
15thyroiditis10.4
16transitional cell carcinoma10.4
17hypervitaminosis d10.4FGF23, CYP27B1
18paraneoplastic syndromes10.4FGF23, PTHLH
19osteomyelitis10.4TNFSF11
20x-linked hypophosphatemia10.4CYP27B1, FGF23
21periapical granuloma10.3TNFSF11
22metaphyseal dysplasia10.3PTH1R, PTHLH
23goiter10.3BGLAP
24calcinosis10.3CASR, FGF23
25hyperostosis10.3BGLAP, FGF23
26skeletal dysplasia multi-gene panels10.3PTH1R, PTHLH
27dwarfism10.3PTH1R, PTHLH
28hyperparathyroidism, neonatal10.3NR1I3, CASR
29parathyroid adenoma10.3CASR, PTHLH
30cholangiocarcinoma10.3
31severe combined immunodeficiency10.3
32ameloblastoma10.3
33large cell carcinoma10.3
34decubitus ulcer10.3
35small cell carcinoma10.3
36adenosquamous carcinoma10.3
37lymphosarcoma10.3
38cystic teratoma10.3
39epidermolysis bullosa10.3
40epithelioid sarcoma10.3
41leiomyosarcoma10.3
42recessive dystrophic epidermolysis bullosa10.3
43multiple endocrine neoplasia10.3
44teratoma10.3
45dysgerminoma10.3
46hyperphosphatemia10.2CASR, FGF23
47brachydactyly10.2ADCY10
48nephrocalcinosis10.2CASR, NR1I3
49osteogenesis imperfecta10.2PTH1R, BGLAP
50osteitis fibrosa10.2CASR, BGLAP

Graphical network of the top 20 diseases related to Humoral Hypercalcemia of Malignancy:



Diseases related to humoral hypercalcemia of malignancy

Symptoms for Humoral Hypercalcemia of Malignancy

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Drugs & Therapeutics for Humoral Hypercalcemia of Malignancy

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Drug clinical trials:

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Genetic Tests for Humoral Hypercalcemia of Malignancy

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Anatomical Context for Humoral Hypercalcemia of Malignancy

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MalaCards organs/tissues related to Humoral Hypercalcemia of Malignancy:

32
Bone, Lung, Thyroid, Breast, T cells, Liver, Pancreas, Skin, Pancreatic islet

Animal Models for Humoral Hypercalcemia of Malignancy or affiliated genes

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Publications for Humoral Hypercalcemia of Malignancy

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Articles related to Humoral Hypercalcemia of Malignancy:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Squamous Cell Carcinoma (Marjolin's Ulcer) Arising in a Sacral Decubitus Ulcer Resulting in Humoral Hypercalcemia of Malignancy. (25197285)
2014
2
Humoral hypercalcemia of malignancy caused by parathyroid hormone-related peptide-secreting neuroendocrine tumors. Report of six cases. (23719609)
2013
3
Primary epithelioid sarcoma of the scalp complicated by humoral hypercalcemia of malignancy. (23359842)
2012
4
A Male Patient with Humoral Hypercalcemia of Malignancy (HHM) with Leukocytosis Caused by Cutaneous Squamous Cell Carcinoma Resulting from Recessive Dystrophic Epidermolysis Bullosa. (23926398)
2011
5
Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1. (21483254)
2011
6
Humoral hypercalcemia of malignancy in a patient with large cell carcinoma of the lung: report of case and review of literature. (17669716)
2007
7
Humoral hypercalcemia of malignancy presenting after oncologic surgery. (16625146)
2006
8
The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy. (15845617)
2005
9
Establishment of a transplantable rat pulmonary carcinoma-derived cell line (IP-B12) as a new model of humoral hypercalcemia of malignancy and bone metastasis. (12853701)
2003
10
PTHrP-producing tumor: squamous cell carcinoma of the liver accompanied by humoral hypercalcemia of malignancy, increased IL-6 and leukocytosis. (12058886)
2002
11
Humoral hypercalcemia of malignancy: severe combined immunodeficient/beige mouse model of adult T-cell lymphoma independent of human T-cell lymphotropic virus type-1 tax expression. (11395400)
2001
12
Parathyroid hormone-related protein-(1--36) stimulates renal tubular calcium reabsorption in normal human volunteers: implications for the pathogenesis of humoral hypercalcemia of malignancy. (11297578)
2001
13
Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy. (11289133)
2001
14
Immunohistochemical detection of parathyroid hormone-related protein in a squamous cell carcinoma arising from mature cystic teratoma causing humoral hypercalcemia of malignancy. (11104629)
2000
15
Osteoprotegerin prevents and reverses hypercalcemia in a murine model of humoral hypercalcemia of malignancy. (10706080)
2000
16
Undifferentiated pancreatic cancer associated with humoral hypercalcemia of malignancy. (9793031)
1998
17
Ultrastructural and histomorphometric evaluations of gallium nitrate on bone in nude mice bearing a canine adenocarcinoma (CAC-8) model of humoral hypercalcemia of malignancy. (7725596)
1995
18
Morphological characteristics of tumors with humoral hypercalcemia of malignancy: functional morphology of PTHrP. (7878296)
1994
19
Circulating forms of immunoreactive parathyroid hormone-related protein for identifying patients with humoral hypercalcemia of malignancy: a comparative study with C-terminal(109-141)- and N-terminal(1-86)-region-specific PTHrP radioassay. (7702967)
1994
20
Clinical picture of humoral hypercalcemia of malignancy. (7878290)
1994
21
Humoral hypercalcemia of malignancy associated with parathyroid hormone-related protein producing transitional cell carcinoma of the ureter. (8019040)
1994
22
Osseous and intestinal compartments in the humoral hypercalcemia of malignancy associated to Walker 256 tumor in rats. (8451038)
1993
23
NMR solution structure of the [Ala26]parathyroid-hormone-related protein(1-34) expressed in humoral hypercalcemia of malignancy. (8425530)
1993
24
Ascites sarcoma 180, an animal model of humoral hypercalcemia of malignancy, produces a factor(s) exhibiting potent bone-resorbing activity without any parathyroid hormone-like activity. (1651137)
1991
25
Increased production of tumor necrosis factor by normal immune cells in a model of the humoral hypercalcemia of malignancy. (2232714)
1990
26
Humoral hypercalcemia of malignancy. (2331805)
1990
27
Parathyroid hormone-related protein in tumor tissues obtained from patients with humoral hypercalcemia of malignancy. (2293655)
1990
28
Humoral hypercalcemia of malignancy. (2693318)
1989
29
Contrasting mechanisms of hypercalcemia in patients with early and advanced humoral hypercalcemia of malignancy. (2718773)
1989
30
Humoral hypercalcemia of malignancy. The role of parathyroid hormone-related protein. (2673773)
1989
31
Synthetic peptides as tools for investigating the pathogenicity of disease: humoral hypercalcemia of malignancy. (2520752)
1989
32
Isolation of 16,000-dalton parathyroid hormone-like proteins from two animal tumors causing humoral hypercalcemia of malignancy. (3197642)
1988
33
Humoral hypercalcemia of malignancy. (3056542)
1988
34
Pathogenesis of humoral hypercalcemia of malignancy. (3066580)
1988
35
Humoral hypercalcemia of malignancy in canine lymphosarcoma. (2828006)
1988
36
Expression of parathyroid hormone-related protein mRNA in tumors obtained from patients with humoral hypercalcemia of malignancy. (3137193)
1988
37
Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy. (2454953)
1988
38
A hypercalcemic nude rat model that completely mimics human syndrome of humoral hypercalcemia of malignancy. (3142674)
1988
39
Humoral hypercalcemia of malignancy in nude mouse model of a canine adenocarcinoma derived from apocrine glands of the anal sac. Biochemical, histomorphometric, and ultrastructural studies. (3012199)
1986
40
Nephrogenous cyclic AMP, adenylate cyclase-stimulating activity, and the humoral hypercalcemia of malignancy. (3016837)
1986
41
Messenger ribonucleic acid from tumors associated with humoral hypercalcemia of malignancy directs the synthesis of a secretory parathyroid hormone-like peptide. (4040850)
1985
42
Biochemical and histomorphometric characterization of a rat model for humoral hypercalcemia of malignancy. (6546543)
1984
43
Failure of parathyroid hormone antagonists to inhibit in vitro bone resorbing activity produced by two animal models of the humoral hypercalcemia of malignancy. (6470137)
1984
44
Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy. (6577602)
1983
45
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy. (6298791)
1983
46
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. (6685137)
1983
47
The effects of dichloromethylene diphosphonate on hypercalcemia and other parameters of the humoral hypercalcemia of malignancy in the rat Leydig cell tumor. (6311375)
1983
48
Humoral hypercalcemia of malignancy: a syndrome in search of a hormone. (6291389)
1982
49
Is there a role for parathyroid hormone in humoral hypercalcemia of malignancy? (6300632)
1982
50
Bone resorption and humoral hypercalcemia of malignancy: stimulation of bone resorption in vitro by tumor extracts is inhibited by prostaglandin synthesis inhibitors. (6793615)
1981

Variations for Humoral Hypercalcemia of Malignancy

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Expression for genes affiliated with Humoral Hypercalcemia of Malignancy

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Expression patterns in normal tissues for genes affiliated with Humoral Hypercalcemia of Malignancy

Search GEO for disease gene expression data for Humoral Hypercalcemia of Malignancy.

Pathways for genes affiliated with Humoral Hypercalcemia of Malignancy

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Pathways related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NR1I3, CYP27B1
29.7BGLAP, FGF23
39.4TNFRSF11A, TNFSF11
49.2FGF23, PTH1R, TNFSF11
58.9TNFRSF11A, TNF, TNFSF11
68.9TNFRSF11A, TNF, TNFSF11
78.9TNFRSF11A, TNF, TNFSF11
8
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
8.9TNFRSF11A, TNF, TNFSF11
9
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.9TNFSF11, TNF, TNFRSF11A
10
Show member pathways
8.9TNFSF11, TNF, TNFRSF11A
11
Show member pathways
8.9TNFSF11, TNF, TNFRSF11A
128.9TNFSF11, TNF, TNFRSF11A
138.7BGLAP, TNFSF11, PTH1R, PTHLH
14
Show member pathways
8.6TNFRSF11A, TNF, TNFSF11, FGF23
15
Show member pathways
8.6TNFRSF11A, TNF, TNFSF11, FGF23
16
Show member pathways
8.6FGF23, TNFSF11, TNF, TNFRSF11A
177.8PTH1R, TNFSF11, TNF, TNFRSF11A, BGLAP, CYP27B1

Compounds for genes affiliated with Humoral Hypercalcemia of Malignancy

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Compounds related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1calcifediol6110.1CYP27B1, NR1I3
2alfacalcidol44 61 1111.8NR1I3, BGLAP, CYP27B1
3calcipotriol44 61 28 1112.7NR1I3, BGLAP, CYP27B1
422-oxacalcitriol449.6PTHLH, CASR, BGLAP
5sevelamer449.6FGF23, CASR, BGLAP
6eb 108944 6110.5PTHLH, NR1I3, BGLAP, CYP27B1
7tartrate449.5PTHLH, TNFSF11, BGLAP
8clodronate44 50 1111.5BGLAP, TNFSF11, PTHLH
9teriparatide44 1110.4BGLAP, TNFSF11, PTH1R
10zoledronic acid449.4BGLAP, PTHLH, TNFSF11
11alendronate44 50 1111.4PTHLH, BGLAP, TNFSF11
1224,25-dihydroxyvitamin d3449.3ADCY10, BGLAP, CYP27B1
13ccl444 2810.2PTH1R, PTHLH, TNFSF11
14raloxifene44 50 28 1112.2BGLAP, TNFRSF11A, TNFSF11
15ns 39844 6110.1TNFSF11, BGLAP, TNF
16amrinone44 1110.1ADCY10, TNF
17ribonucleic acid449.1NR1I3, CASR, PTHLH, PTH1R
18pamidronate44 50 1111.0PTHLH, BGLAP, CASR, TNFSF11
19infliximab44 50 1111.0BGLAP, TNFSF11, TNF
20octreotide44 61 28 1112.0PTHLH, FGF23, ADCY10
21estradiol44 24 1110.8CYP27B1, BGLAP, NR1I3, TNFSF11, PTHLH
22inositol 1,4,5 trisphosphate448.7PTH1R, NR1I3, ADCY10, CASR
23hydrogen44 249.7CASR, PTHLH, PTH1R, CYP27B1, TNFSF11
24testosterone44 61 24 1111.7PTHLH, TNFSF11, BGLAP, CYP27B1, NR1I3
25steroid448.7NR1I3, PTHLH, PTH1R, TNFSF11, CYP27B1
26creatinine448.6TNFSF11, PTHLH, CASR, FGF23, BGLAP
27retinoic acid44 249.5NR1I3, PTH1R, PTHLH, TNF, CYP27B1, BGLAP
2825-hydroxyvitamin d448.4FGF23, CYP27B1, TNFSF11, PTHLH, CASR, BGLAP
29cyclosporin a44 28 6110.4TNF, BGLAP, CASR, TNFSF11, NR1I3
30oxygen44 249.3PTHLH, CYP27B1, TNFRSF11A, TNF, TNFSF11, NR1I3
31hydroxyapatite448.3BGLAP, PTHLH, TNFSF11, TNFRSF11A, CASR, FGF23
32indomethacin44 28 61 1111.3ADCY10, PTHLH, TNFSF11, TNF
33lipid448.2PTHLH, TNFSF11, CYP27B1, TNF, NR1I3, TNFRSF11A
34prostaglandin448.2ADCY10, TNFSF11, TNF, TNFRSF11A, PTHLH
35cycloheximide448.2TNF, ADCY10, PTHLH, CYP27B1, TNFSF11
36nitric oxide44 24 1110.1CASR, TNFSF11, PTHLH, TNFRSF11A, PTH1R, TNF
37arginine448.1ADCY10, NR1I3, BGLAP, PTHLH, FGF23, CASR
38tyrosine448.0TNFRSF11A, CYP27B1, CASR, TNFSF11, PTHLH, NR1I3
39forskolin44 50 1110.0PTH1R, PTHLH, ADCY10, CASR, CYP27B1, TNFSF11
40vegf447.9BGLAP, PTHLH, TNFRSF11A, TNF, TNFSF11
41phosphorus447.7CASR, CYP27B1, TNFSF11, PTH1R, PTHLH, NR1I3
42vitamin d447.7FGF23, NR1I3, PTH1R, CYP27B1, CASR, BGLAP
43cyclic amp44 248.6CYP27B1, CASR, NR1I3, PTH1R, PTHLH, ADCY10
44estrogen447.6NR1I3, CASR, PTHLH, PTH1R, TNFSF11, BGLAP
451,25 dihydroxy vitamin d3447.3CYP27B1, FGF23, PTH1R, TNFRSF11A, BGLAP, CASR
46dexamethasone44 50 28 1110.1NR1I3, PTHLH, PTH1R, TNFSF11, TNF, TNFRSF11A
47serine447.0PTH1R, CASR, NR1I3, PTHLH, TNFSF11, TNF
48calcitriol44 61 24 119.8TNF, FGF23, NR1I3, CASR, CYP27B1, BGLAP
49pge2446.6BGLAP, CYP27B1, TNFRSF11A, ADCY10, CASR, PTHLH
50calcium44 50 24 119.5NR1I3, BGLAP, TNFRSF11A, TNFSF11, FGF23, PTH1R

GO Terms for genes affiliated with Humoral Hypercalcemia of Malignancy

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Cellular components related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.4CASR, PTH1R, TNFSF11, TNF
2extracellular spaceGO:0056158.2FGF23, PTHLH, TNFSF11, TNF, BGLAP
3extracellular regionGO:0055768.0BGLAP, TNF, TNFSF11, PTHLH, FGF23

Biological processes related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1vitamin D catabolic processGO:04236910.2CYP27B1, FGF23
2positive regulation of vitamin D 24-hydroxylase activityGO:01098010.2CYP27B1, FGF23
3response to vitamin DGO:03328010.0BGLAP, CYP27B1
4regulation of bone mineralizationGO:03050010.0CYP27B1, BGLAP
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.9PTH1R, PTHLH
6positive regulation of fever generation by positive regulation of prostaglandin secretionGO:0718129.8TNFSF11, TNFRSF11A
7TNFSF11-mediated signaling pathwayGO:0718479.8TNFSF11, TNFRSF11A
8positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:0718489.8TNFSF11, TNFRSF11A
9calcium ion homeostasisGO:0550749.8TNFSF11, CYP27B1
10osteoblast developmentGO:0020769.8PTHLH, PTH1R, BGLAP
11mammary gland alveolus developmentGO:0607499.7TNFSF11, TNFRSF11A
12negative regulation of osteoblast differentiationGO:0456689.7FGF23, TNF
13bone mineralizationGO:0302829.7CYP27B1, BGLAP, PTH1R
14positive regulation of JUN kinase activityGO:0435079.7TNF, TNFRSF11A
15response to estrogenGO:0436279.7BGLAP, CYP27B1
16monocyte chemotaxisGO:0025489.7TNFSF11, TNFRSF11A
17bone resorptionGO:0454539.7TNFSF11, PTH1R
18skeletal system developmentGO:0015019.7BGLAP, PTH1R, PTHLH
19response to activityGO:0148239.6TNF, BGLAP
20positive regulation of osteoclast differentiationGO:0456729.6TNFSF11, TNF
21response to mechanical stimulusGO:0096129.4TNF, BGLAP
22positive regulation of MAP kinase activityGO:0434069.3TNFSF11, TNF
23negative regulation of cell proliferationGO:0082859.3CYP27B1, TNF, PTH1R, PTHLH
24osteoclast differentiationGO:0303169.3TNFRSF11A, TNF, TNFSF11
25tumor necrosis factor-mediated signaling pathwayGO:0332099.3TNFSF11, TNF, TNFRSF11A
26ossificationGO:0015039.3CASR, TNFSF11, TNFRSF11A
27positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3TNFRSF11A, TNF, TNFSF11
28positive regulation of NF-kappaB transcription factor activityGO:0510929.2TNFSF11, TNF, TNFRSF11A
29positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.2TNFSF11, TNF, TNFRSF11A
30positive regulation of JNK cascadeGO:0463309.0TNFSF11, TNF

Molecular functions related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.3TNFSF11, TNF

Products for genes affiliated with Humoral Hypercalcemia of Malignancy

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