MCID: HMR009
MIFTS: 30

Humoral Hypercalcemia of Malignancy malady

Summaries for Humoral Hypercalcemia of Malignancy

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Humoral Hypercalcemia of Malignancy is related to hypercalcemia and adenocarcinoma. An important gene associated with Humoral Hypercalcemia of Malignancy is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Prostacyclin signalling through prostacyclin receptor and Nuclear receptors in lipid metabolism and toxicity. The compounds pge2 and forskolin have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Humoral Hypercalcemia of Malignancy

Sources:
47OMIM
See all sources

Aliases & Descriptions:

humoral hypercalcemia of malignancy 47


Related Diseases for Humoral Hypercalcemia of Malignancy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Humoral Hypercalcemia of Malignancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia31.8CASR, TNFRSF11A, TNFSF11, ADCY10, PTHLH, PTH1R
2adenocarcinoma30.9CYP27B1, ADCY10, CASR, TNFSF11, PTHLH
3primary hyperparathyroidism30.6PTHLH, PTH1R, FGF23, CYP27B1, NR1I3, CASR
4bone carcinoma30.5TNFSF11, TNFRSF11A, PTHLH, BGLAP
5dysgerminoma30.3PTHLH
6hypoparathyroidism30.3CASR, PTHLH, PTH1R, FGF23, BGLAP, NR1I3
7squamous cell carcinoma10.7
8parathyroid carcinoma10.6
9anal gland adenocarcinoma10.4
10apocrine adenocarcinoma10.4
11transitional cell carcinoma10.4
12esophagus small cell carcinoma10.2
13adenosquamous pancreas carcinoma10.2
14small cell carcinoma10.2
15lymphosarcoma10.2
16adult lymphoma10.2
17n syndrome10.2
18adenosquamous carcinoma10.2
19large cell carcinoma10.2
20skin squamous cell carcinoma10.2
21ureter transitional cell carcinoma10.2
22recessive dystrophic epidermolysis bullosa10.2
23multiple endocrine neoplasia10.2
24teratoma10.2
25adult t-cell leukemia10.0PTHLH
26paget's disease of bone10.0TNFRSF11A
27mccune albright syndrome10.0FGF23
28ollier disease10.0PTHLH
29pancreatitis10.0CASR
30cholesteatoma10.0TNFSF11
31peritonitis10.0TNF
32osteosclerosis10.0TNFSF11
33chondroblastoma10.0PTHLH
34vascular disease10.0TNF
35gingivitis10.0TNFSF11
36ankylosing spondylitis10.0TNF
37osteomyelitis10.0TNFSF11
38chondrosarcoma10.0PTHLH, PTH1R
39galactosemia10.0TNF
40multiple myeloma10.0TNFSF11
41periapical granuloma10.0TNFSF11
42cholestasis10.0NR1I3
43osteochondrodysplasia10.0PTHLH, PTH1R
44choriocarcinoma10.0ADCY10
45achondroplasia10.0PTH1R
46metaphyseal dysplasia10.0PTH1R, PTHLH
47colon cancer10.0CASR, CYP27B1
48parathyroid adenoma10.0PTHLH, CASR
49hypervitaminosis d10.0CYP27B1, FGF23
50adenoma10.0NR1I3, CASR

Graphical network of the top 20 diseases related to Humoral Hypercalcemia of Malignancy:



Diseases related to humoral hypercalcemia of malignancy

Clinical Features for Humoral Hypercalcemia of Malignancy

Drugs & Therapeutics for Humoral Hypercalcemia of Malignancy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Humoral Hypercalcemia of Malignancy

Drug clinical trials:

Search ClinicalTrials for Humoral Hypercalcemia of Malignancy

Search NIH Clinical Center for Humoral Hypercalcemia of Malignancy

Search CenterWatch for Humoral Hypercalcemia of Malignancy

Genetic Tests for Humoral Hypercalcemia of Malignancy

Anatomical Context for Humoral Hypercalcemia of Malignancy

Animal Models for Humoral Hypercalcemia of Malignancy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Humoral Hypercalcemia of Malignancy

Genetic Variations for Humoral Hypercalcemia of Malignancy

Expression for genes affiliated with Humoral Hypercalcemia of Malignancy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Humoral Hypercalcemia of Malignancy

Search GEO for disease gene expression data for Humoral Hypercalcemia of Malignancy.

Pathways for genes affiliated with Humoral Hypercalcemia of Malignancy

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 52QIAGEN, 56SinoBiological, 53R&D Systems, 4Cell Signaling Technology
See all sources

Pathways related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9PTH1R, PTHLH
29.8CYP27B1, NR1I3
39.6TNFRSF11A, TNFSF11
49.2PTH1R, FGF23, TNFSF11
5
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
8.8BGLAP, TNFSF11, PTH1R, PTHLH
68.8TNFRSF11A, TNFSF11, TNF
7
Hide members
8.8TNFRSF11A, TNFSF11, TNF
88.8TNFRSF11A, TNFSF11, TNF
9
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
8.8TNFRSF11A, TNFSF11, TNF
108.8TNF, TNFSF11, TNFRSF11A
11
Hide members
8.8TNF, TNFSF11, TNFRSF11A
128.8TNF, TNFSF11, TNFRSF11A
13
Hide members
8.8TNF, TNFSF11, TNFRSF11A
14
Hide members
8.4TNFRSF11A, TNFSF11, TNF, FGF23
15
Hide members
8.4TNFRSF11A, TNFSF11, TNF, FGF23
16
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
7.6PTH1R, CYP27B1, TNF, TNFSF11, TNFRSF11A, BGLAP

Compounds for genes affiliated with Humoral Hypercalcemia of Malignancy

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1pge24510.6PTH1R
2forskolin45 50 1112.6PTH1R
3estradiol45 11 2412.2PTHLH, NR1I3
4cycloheximide4510.1ADCY10
5calcifediol6010.1CYP27B1, NR1I3
6clodronate45 50 1112.1PTHLH, TNFSF11
7alfacalcidol45 60 1111.7NR1I3, CYP27B1, BGLAP
8calcipotriol45 60 29 1112.7NR1I3, BGLAP, CYP27B1
922-oxacalcitriol459.6CASR, PTHLH, BGLAP
10adenosine 3,5-cyclic monophosphorothioate459.6PTHLH, ADCY10
11tartrate459.5BGLAP, PTHLH, TNFSF11
12sevelamer459.5CASR, BGLAP, FGF23
13teriparatide45 1110.5TNFSF11, PTH1R, BGLAP
14ccl445 2910.5PTH1R, PTHLH, TNFSF11
15zoledronic acid459.5TNFSF11, BGLAP, PTHLH
16alendronate45 50 1111.5TNFSF11, PTHLH, BGLAP
1724,25-dihydroxyvitamin d3459.4CYP27B1, ADCY10, BGLAP
18eb 108945 6010.4CYP27B1, PTHLH, BGLAP, NR1I3
19strontium ranelate459.4TNFSF11, CASR
20raloxifene45 29 50 1112.3BGLAP, TNFSF11, TNFRSF11A
21denosumab45 1110.3TNFRSF11A, TNFSF11
22octreotide45 60 29 1112.3FGF23, PTHLH, ADCY10
23ribonucleic acid459.3CASR, PTHLH, PTH1R, NR1I3
24amrinone45 1110.2TNF, ADCY10
25pamidronate45 50 1111.1CASR, PTHLH, TNFSF11, BGLAP
26inositol 1,4,5 trisphosphate459.0ADCY10, NR1I3, PTH1R, CASR
27hydrogen45 249.9CASR, TNFSF11, PTHLH, PTH1R, CYP27B1
28ns 39845 609.9TNF, TNFSF11, BGLAP
29infliximab45 50 1110.8TNFSF11, TNF, BGLAP
30steroid458.7CYP27B1, PTHLH, PTH1R, NR1I3, TNFSF11
31testosterone45 60 11 2411.7BGLAP, PTHLH, NR1I3, CYP27B1, TNFSF11
32creatinine458.6BGLAP, CASR, TNFSF11, FGF23, PTHLH
33dexamethasone45 50 29 1111.5ADCY10, BGLAP, TNFSF11, PTH1R, NR1I3
3425-hydroxyvitamin d458.4PTHLH, BGLAP, CASR, TNFSF11, FGF23, CYP27B1
35hydroxyapatite458.4PTHLH, BGLAP, CASR, TNFRSF11A, TNFSF11, FGF23
36prostaglandin458.3TNF, PTHLH, ADCY10, TNFRSF11A, TNFSF11
37arginine458.2FGF23, BGLAP, NR1I3, PTHLH, ADCY10, CASR
38retinoic acid45 249.2NR1I3, PTH1R, CYP27B1, PTHLH, TNF, BGLAP
39oxygen45 249.2PTHLH, TNFRSF11A, CYP27B1, NR1I3, TNFSF11, TNF
40cyclosporin a45 29 6010.1NR1I3, TNF, TNFSF11, CASR, BGLAP
41nitric oxide45 11 2410.1PTHLH, PTH1R, TNF, TNFSF11, TNFRSF11A, CASR
42tyrosine458.1TNFSF11, NR1I3, CYP27B1, TNFRSF11A, FGF23, PTHLH
43cyclic amp45 249.0NR1I3, CASR, TNFSF11, CYP27B1, ADCY10, PTHLH
44lipid457.9TNFSF11, TNFRSF11A, PTHLH, TNF, CYP27B1, NR1I3
45phosphorus457.7FGF23, PTH1R, PTHLH, CYP27B1, BGLAP, CASR
46vitamin d457.7TNFSF11, CASR, BGLAP, NR1I3, CYP27B1, FGF23
471,25 dihydroxy vitamin d3457.4BGLAP, CASR, TNFRSF11A, TNFSF11, NR1I3, CYP27B1
48serine456.8PTHLH, PTH1R, FGF23, NR1I3, TNF, TNFRSF11A
49calcium45 50 11 249.7TNFRSF11A, CASR, BGLAP, ADCY10, PTHLH, PTH1R
50calcitriol45 60 11 249.6TNF, BGLAP, CASR, TNFRSF11A, PTHLH, PTH1R

GO Terms for genes affiliated with Humoral Hypercalcemia of Malignancy

Sources:
16Gene Ontology
See all sources

Cellular components related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.9PTHLH, FGF23, TNF, TNFSF11, BGLAP

Biological processes related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:01098010.1FGF23, CYP27B1
2vitamin D catabolic processGO:04236910.1FGF23, CYP27B1
3positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.0TNFRSF11A, TNFSF11
4TNFSF11-mediated signaling pathwayGO:0718479.9TNFRSF11A, TNFSF11
5positive regulation of fever generation by positive regulation of prostaglandin secretionGO:0718129.9TNFRSF11A, TNFSF11
6response to vitamin DGO:0332809.9CYP27B1, BGLAP
7mammary gland alveolus developmentGO:0607499.8TNFSF11, TNFRSF11A
8regulation of bone mineralizationGO:0305009.8BGLAP, CYP27B1
9monocyte chemotaxisGO:0025489.8TNFRSF11A, TNFSF11
10calcium ion homeostasisGO:0550749.7CYP27B1, TNFSF11
11osteoblast developmentGO:0020769.7PTHLH, PTH1R, BGLAP
12bone mineralizationGO:0302829.7PTH1R, CYP27B1, BGLAP
13bone resorptionGO:0454539.6TNFSF11, PTH1R
14skeletal system developmentGO:0015019.6BGLAP, PTH1R, PTHLH
15ossificationGO:0015039.5CASR, TNFRSF11A, TNFSF11
16positive regulation of osteoclast differentiationGO:0456729.3TNFSF11, TNF
17negative regulation of osteoblast differentiationGO:0456689.2FGF23, TNF
18osteoclast differentiationGO:0303169.1TNF, TNFSF11, TNFRSF11A
19tumor necrosis factor-mediated signaling pathwayGO:0332099.1TNFRSF11A, TNFSF11, TNF
20positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1TNF, TNFSF11, TNFRSF11A
21positive regulation of NF-kappaB transcription factor activityGO:0510929.1TNF, TNFSF11, TNFRSF11A
22response to activityGO:0148239.0TNF, BGLAP
23negative regulation of cell proliferationGO:0082859.0TNF, CYP27B1, PTH1R, PTHLH
24positive regulation of JUN kinase activityGO:0435079.0TNF, TNFRSF11A
25positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431238.9TNF, TNFSF11, TNFRSF11A

Molecular functions related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.1TNF, TNFSF11

Products for genes affiliated with Humoral Hypercalcemia of Malignancy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Humoral Hypercalcemia of Malignancy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet