MCID: HMR009
MIFTS: 47

Humoral Hypercalcemia of Malignancy malady

Summaries for Humoral Hypercalcemia of Malignancy

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MalaCards: Humoral Hypercalcemia of Malignancy is related to hypercalcemia and adenocarcinoma. An important gene associated with Humoral Hypercalcemia of Malignancy is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Nuclear receptors in lipid metabolism and toxicity and FGF signaling pathway. The compounds calcifediol and alfacalcidol have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and thyroid, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Classifications for Humoral Hypercalcemia of Malignancy

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48OMIM
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Aliases & Descriptions:

humoral hypercalcemia of malignancy 48


Related Diseases for Humoral Hypercalcemia of Malignancy

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18GeneCards, 19GeneDecks
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Diseases related to Humoral Hypercalcemia of Malignancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia31.5FGF23, NR1I3, CASR, ADCY10, PTHLH, PTH1R
2adenocarcinoma30.8CYP27B1, TNFSF11, PTHLH, ADCY10, CASR
3leydig cell tumor30.7PTHLH, ADCY10
4primary hyperparathyroidism30.6FGF23, NR1I3, CASR, PTHLH, PTH1R, BGLAP
5hyperparathyroidism30.6FGF23, NR1I3, CASR, ADCY10, PTHLH, TNFSF11
6breast cancer30.3CYP27B1, TNFRSF11A, TNFSF11, PTH1R, PTHLH, ADCY10
7hypoparathyroidism30.2FGF23, NR1I3, CASR, PTHLH, PTH1R, BGLAP
8pancreatitis10.6
9pancreatic cancer10.5
10neuroendocrine tumor10.4
11sarcoma10.4
12thyroiditis10.4
13transitional cell carcinoma10.4
14lymphosarcoma10.2
15large cell carcinoma10.2
16small cell carcinoma10.2
17adenosquamous carcinoma10.2
18cholangiocarcinoma10.2
19cystic teratoma10.2
20epidermolysis bullosa10.2
21epithelioid sarcoma10.2
22leiomyosarcoma10.2
23severe combined immunodeficiency10.2
24recessive dystrophic epidermolysis bullosa10.2
25multiple endocrine neoplasia10.2
26teratoma10.2
27dysgerminoma10.2
28ollier disease10.1PTHLH
29mccune albright syndrome10.1FGF23
30paget's disease of bone10.1TNFRSF11A
31hypervitaminosis d10.1CYP27B1, FGF23
32paraneoplastic syndromes10.1FGF23, PTHLH
33osteomyelitis10.1TNFSF11
34osteochondrodysplasia10.1PTHLH, PTH1R
35x-linked hypophosphatemia10.1FGF23, CYP27B1
36periapical granuloma10.1TNFSF11
37metaphyseal dysplasia10.1PTHLH, PTH1R
38goiter10.1BGLAP
39calcinosis10.1CASR, FGF23
40skeletal dysplasias10.1PTHLH, PTH1R
41hyperostosis10.1FGF23, BGLAP
42dwarfism10.1PTHLH, PTH1R
43hyperparathyroidism, neonatal10.1CASR, NR1I3
44parathyroid adenoma10.1PTHLH, CASR
45hyperphosphatemia10.1FGF23, CASR
46brachydactyly10.1ADCY10
47nephrocalcinosis10.1CASR, NR1I3
48osteogenesis imperfecta10.0BGLAP, PTH1R
49osteitis fibrosa10.0BGLAP, CASR
50paget disease, juvenile10.0TNFRSF11A, TNFSF11

Graphical network of the top 20 diseases related to Humoral Hypercalcemia of Malignancy:



Diseases related to humoral hypercalcemia of malignancy

Symptoms for Humoral Hypercalcemia of Malignancy

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Drugs & Therapeutics for Humoral Hypercalcemia of Malignancy

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Genetic Tests for Humoral Hypercalcemia of Malignancy

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Anatomical Context for Humoral Hypercalcemia of Malignancy

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MalaCards organs/tissues related to Humoral Hypercalcemia of Malignancy:

34
Bone, Lung, Thyroid, Breast, T cells, Liver, Pancreas, Skin, Pancreatic islet

Animal Models for Humoral Hypercalcemia of Malignancy or affiliated genes

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38MGI
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Publications for Humoral Hypercalcemia of Malignancy

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53PubMed
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Articles related to Humoral Hypercalcemia of Malignancy:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
Humoral hypercalcemia of malignancy caused by parathyroid hormone-related peptide-secreting neuroendocrine tumors. Report of six cases. (23719609)
2013
2
Primary epithelioid sarcoma of the scalp complicated by humoral hypercalcemia of malignancy. (23359842)
2012
3
A Male Patient with Humoral Hypercalcemia of Malignancy (HHM) with Leukocytosis Caused by Cutaneous Squamous Cell Carcinoma Resulting from Recessive Dystrophic Epidermolysis Bullosa. (23926398)
2011
4
Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1. (21483254)
2011
5
Humoral hypercalcemia of malignancy in a patient with large cell carcinoma of the lung: report of case and review of literature. (17669716)
2007
6
Humoral hypercalcemia of malignancy presenting after oncologic surgery. (16625146)
2006
7
The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy. (15845617)
2005
8
Establishment of a transplantable rat pulmonary carcinoma-derived cell line (IP-B12) as a new model of humoral hypercalcemia of malignancy and bone metastasis. (12853701)
2003
9
PTHrP-producing tumor: squamous cell carcinoma of the liver accompanied by humoral hypercalcemia of malignancy, increased IL-6 and leukocytosis. (12058886)
2002
10
Humoral hypercalcemia of malignancy: severe combined immunodeficient/beige mouse model of adult T-cell lymphoma independent of human T-cell lymphotropic virus type-1 tax expression. (11395400)
2001
11
Parathyroid hormone-related protein-(1--36) stimulates renal tubular calcium reabsorption in normal human volunteers: implications for the pathogenesis of humoral hypercalcemia of malignancy. (11297578)
2001
12
Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy. (11289133)
2001
13
Immunohistochemical detection of parathyroid hormone-related protein in a squamous cell carcinoma arising from mature cystic teratoma causing humoral hypercalcemia of malignancy. (11104629)
2000
14
Osteoprotegerin prevents and reverses hypercalcemia in a murine model of humoral hypercalcemia of malignancy. (10706080)
2000
15
Undifferentiated pancreatic cancer associated with humoral hypercalcemia of malignancy. (9793031)
1998
16
Ultrastructural and histomorphometric evaluations of gallium nitrate on bone in nude mice bearing a canine adenocarcinoma (CAC-8) model of humoral hypercalcemia of malignancy. (7725596)
1995
17
Morphological characteristics of tumors with humoral hypercalcemia of malignancy: functional morphology of PTHrP. (7878296)
1994
18
Circulating forms of immunoreactive parathyroid hormone-related protein for identifying patients with humoral hypercalcemia of malignancy: a comparative study with C-terminal(109-141)- and N-terminal(1-86)-region-specific PTHrP radioassay. (7702967)
1994
19
Clinical picture of humoral hypercalcemia of malignancy. (7878290)
1994
20
Humoral hypercalcemia of malignancy associated with parathyroid hormone-related protein producing transitional cell carcinoma of the ureter. (8019040)
1994
21
Osseous and intestinal compartments in the humoral hypercalcemia of malignancy associated to Walker 256 tumor in rats. (8451038)
1993
22
NMR solution structure of the [Ala26]parathyroid-hormone-related protein(1-34) expressed in humoral hypercalcemia of malignancy. (8425530)
1993
23
Ascites sarcoma 180, an animal model of humoral hypercalcemia of malignancy, produces a factor(s) exhibiting potent bone-resorbing activity without any parathyroid hormone-like activity. (1651137)
1991
24
Increased production of tumor necrosis factor by normal immune cells in a model of the humoral hypercalcemia of malignancy. (2232714)
1990
25
Humoral hypercalcemia of malignancy. (2331805)
1990
26
Parathyroid hormone-related protein in tumor tissues obtained from patients with humoral hypercalcemia of malignancy. (2293655)
1990
27
Humoral hypercalcemia of malignancy. (2693318)
1989
28
Contrasting mechanisms of hypercalcemia in patients with early and advanced humoral hypercalcemia of malignancy. (2718773)
1989
29
Humoral hypercalcemia of malignancy. The role of parathyroid hormone-related protein. (2673773)
1989
30
Synthetic peptides as tools for investigating the pathogenicity of disease: humoral hypercalcemia of malignancy. (2520752)
1989
31
Isolation of 16,000-dalton parathyroid hormone-like proteins from two animal tumors causing humoral hypercalcemia of malignancy. (3197642)
1988
32
Humoral hypercalcemia of malignancy. (3056542)
1988
33
Pathogenesis of humoral hypercalcemia of malignancy. (3066580)
1988
34
Humoral hypercalcemia of malignancy in canine lymphosarcoma. (2828006)
1988
35
Expression of parathyroid hormone-related protein mRNA in tumors obtained from patients with humoral hypercalcemia of malignancy. (3137193)
1988
36
Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy. (2454953)
1988
37
A hypercalcemic nude rat model that completely mimics human syndrome of humoral hypercalcemia of malignancy. (3142674)
1988
38
Humoral hypercalcemia of malignancy in nude mouse model of a canine adenocarcinoma derived from apocrine glands of the anal sac. Biochemical, histomorphometric, and ultrastructural studies. (3012199)
1986
39
Nephrogenous cyclic AMP, adenylate cyclase-stimulating activity, and the humoral hypercalcemia of malignancy. (3016837)
1986
40
Messenger ribonucleic acid from tumors associated with humoral hypercalcemia of malignancy directs the synthesis of a secretory parathyroid hormone-like peptide. (4040850)
1985
41
Biochemical and histomorphometric characterization of a rat model for humoral hypercalcemia of malignancy. (6546543)
1984
42
Failure of parathyroid hormone antagonists to inhibit in vitro bone resorbing activity produced by two animal models of the humoral hypercalcemia of malignancy. (6470137)
1984
43
Squamous carcinoma model of humoral hypercalcemia of malignancy. (6499773)
1984
44
Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy. (6577602)
1983
45
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy. (6298791)
1983
46
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. (6685137)
1983
47
The effects of dichloromethylene diphosphonate on hypercalcemia and other parameters of the humoral hypercalcemia of malignancy in the rat Leydig cell tumor. (6311375)
1983
48
Humoral hypercalcemia of malignancy: a syndrome in search of a hormone. (6291389)
1982
49
Is there a role for parathyroid hormone in humoral hypercalcemia of malignancy? (6300632)
1982
50
Bone resorption and humoral hypercalcemia of malignancy: stimulation of bone resorption in vitro by tumor extracts is inhibited by prostaglandin synthesis inhibitors. (6793615)
1981

Variations for Humoral Hypercalcemia of Malignancy

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Expression for genes affiliated with Humoral Hypercalcemia of Malignancy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Humoral Hypercalcemia of Malignancy

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Pathways for genes affiliated with Humoral Hypercalcemia of Malignancy

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51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 56Reactome, 5Cell Signaling Technology, 31KEGG, 58SinoBiological, 55R&D Systems
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Pathways related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CYP27B1, NR1I3
29.7FGF23, BGLAP
39.4TNFRSF11A, TNFSF11
49.2FGF23, TNFSF11, PTH1R
5
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
8.9TNFRSF11A, TNF, TNFSF11
68.9TNFRSF11A, TNF, TNFSF11
78.9TNFRSF11A, TNF, TNFSF11
8
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway61
8.9TNFRSF11A, TNF, TNFSF11
9
Show member pathways
8.9TNFRSF11A, TNFSF11, TNF
10
Show member pathways
8.9TNFRSF11A, TNFSF11, TNF
118.9TNFSF11, TNF, TNFRSF11A
128.9TNFSF11, TNF, TNFRSF11A
138.7BGLAP, PTH1R, TNFSF11, PTHLH
14
Show member pathways
8.6TNFRSF11A, TNF, TNFSF11, FGF23
15
Show member pathways
8.6TNFRSF11A, TNF, TNFSF11, FGF23
16
Show member pathways
8.6FGF23, TNFSF11, TNFRSF11A, TNF
177.8TNF, CYP27B1, PTH1R, BGLAP, TNFRSF11A, TNFSF11

Compounds for genes affiliated with Humoral Hypercalcemia of Malignancy

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62Tocris Bioscience, 46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB
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Compounds related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1calcifediol6210.1CYP27B1, NR1I3
2alfacalcidol46 62 1211.8NR1I3, BGLAP, CYP27B1
3calcipotriol46 62 30 1212.7NR1I3, BGLAP, CYP27B1
422-oxacalcitriol469.6PTHLH, CASR, BGLAP
5sevelamer469.6FGF23, CASR, BGLAP
6eb 108946 6210.5PTHLH, NR1I3, BGLAP, CYP27B1
7tartrate469.5PTHLH, TNFSF11, BGLAP
8clodronate46 52 1211.5BGLAP, TNFSF11, PTHLH
9teriparatide46 1210.4BGLAP, TNFSF11, PTH1R
10zoledronic acid469.4BGLAP, PTHLH, TNFSF11
11alendronate46 52 1211.4PTHLH, BGLAP, TNFSF11
1224,25-dihydroxyvitamin d3469.3ADCY10, BGLAP, CYP27B1
13ccl446 3010.2PTH1R, PTHLH, TNFSF11
14raloxifene46 52 30 1212.2BGLAP, TNFRSF11A, TNFSF11
15ns 39846 6210.1TNFSF11, BGLAP, TNF
16amrinone46 1210.1ADCY10, TNF
17ribonucleic acid469.1NR1I3, CASR, PTHLH, PTH1R
18pamidronate46 52 1211.0PTHLH, BGLAP, CASR, TNFSF11
19infliximab46 52 1211.0BGLAP, TNFSF11, TNF
20octreotide46 62 30 1212.0PTHLH, FGF23, ADCY10
21estradiol46 25 1210.8CYP27B1, BGLAP, NR1I3, TNFSF11, PTHLH
22inositol 1,4,5 trisphosphate468.7PTH1R, NR1I3, ADCY10, CASR
23hydrogen46 259.7CASR, PTHLH, PTH1R, CYP27B1, TNFSF11
24testosterone46 62 25 1211.7PTHLH, TNFSF11, BGLAP, CYP27B1, NR1I3
25steroid468.7NR1I3, PTHLH, PTH1R, TNFSF11, CYP27B1
26creatinine468.6TNFSF11, PTHLH, CASR, FGF23, BGLAP
27retinoic acid46 259.5NR1I3, PTH1R, PTHLH, TNF, CYP27B1, BGLAP
2825-hydroxyvitamin d468.4FGF23, CYP27B1, TNFSF11, PTHLH, CASR, BGLAP
29cyclosporin a46 30 6210.4TNF, BGLAP, CASR, TNFSF11, NR1I3
30oxygen46 259.3PTHLH, CYP27B1, TNFRSF11A, TNF, TNFSF11, NR1I3
31hydroxyapatite468.3BGLAP, PTHLH, TNFSF11, TNFRSF11A, CASR, FGF23
32indomethacin46 30 62 1211.3ADCY10, PTHLH, TNFSF11, TNF
33lipid468.2PTHLH, TNFSF11, CYP27B1, TNF, NR1I3, TNFRSF11A
34prostaglandin468.2ADCY10, TNFSF11, TNF, TNFRSF11A, PTHLH
35cycloheximide468.2TNF, ADCY10, PTHLH, CYP27B1, TNFSF11
36nitric oxide46 25 1210.1CASR, TNFSF11, PTHLH, TNFRSF11A, PTH1R, TNF
37arginine468.1ADCY10, NR1I3, BGLAP, PTHLH, FGF23, CASR
38tyrosine468.0TNFRSF11A, CYP27B1, CASR, TNFSF11, PTHLH, NR1I3
39forskolin46 52 1210.0PTH1R, PTHLH, ADCY10, CASR, CYP27B1, TNFSF11
40vegf467.9BGLAP, PTHLH, TNFRSF11A, TNF, TNFSF11
41phosphorus467.7CASR, CYP27B1, TNFSF11, PTH1R, PTHLH, NR1I3
42vitamin d467.7FGF23, NR1I3, PTH1R, CYP27B1, CASR, BGLAP
43cyclic amp46 258.6CYP27B1, CASR, NR1I3, PTH1R, PTHLH, ADCY10
44estrogen467.6NR1I3, CASR, PTHLH, PTH1R, TNFSF11, BGLAP
451,25 dihydroxy vitamin d3467.3CYP27B1, FGF23, PTH1R, TNFRSF11A, BGLAP, CASR
46dexamethasone46 52 30 1210.1NR1I3, PTHLH, PTH1R, TNFSF11, TNF, TNFRSF11A
47serine467.0PTH1R, CASR, NR1I3, PTHLH, TNFSF11, TNF
48calcitriol46 62 25 129.8TNF, FGF23, NR1I3, CASR, CYP27B1, BGLAP
49pge2466.6BGLAP, CYP27B1, TNFRSF11A, ADCY10, CASR, PTHLH
50calcium46 52 25 129.5NR1I3, BGLAP, TNFRSF11A, TNFSF11, FGF23, PTH1R

GO Terms for genes affiliated with Humoral Hypercalcemia of Malignancy

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17Gene Ontology
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Cellular components related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.4CASR, PTH1R, TNFSF11, TNF
2extracellular spaceGO:0056158.2FGF23, PTHLH, TNFSF11, TNF, BGLAP
3extracellular regionGO:0055768.0BGLAP, TNF, TNFSF11, PTHLH, FGF23

Biological processes related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1vitamin D catabolic processGO:04236910.2CYP27B1, FGF23
2positive regulation of vitamin D 24-hydroxylase activityGO:01098010.2CYP27B1, FGF23
3response to vitamin DGO:03328010.0BGLAP, CYP27B1
4regulation of bone mineralizationGO:03050010.0CYP27B1, BGLAP
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.9PTH1R, PTHLH
6positive regulation of fever generation by positive regulation of prostaglandin secretionGO:0718129.8TNFSF11, TNFRSF11A
7TNFSF11-mediated signaling pathwayGO:0718479.8TNFSF11, TNFRSF11A
8positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:0718489.8TNFSF11, TNFRSF11A
9calcium ion homeostasisGO:0550749.8TNFSF11, CYP27B1
10osteoblast developmentGO:0020769.8PTHLH, PTH1R, BGLAP
11mammary gland alveolus developmentGO:0607499.7TNFSF11, TNFRSF11A
12negative regulation of osteoblast differentiationGO:0456689.7FGF23, TNF
13bone mineralizationGO:0302829.7CYP27B1, BGLAP, PTH1R
14positive regulation of JUN kinase activityGO:0435079.7TNF, TNFRSF11A
15response to estrogenGO:0436279.7BGLAP, CYP27B1
16monocyte chemotaxisGO:0025489.7TNFSF11, TNFRSF11A
17bone resorptionGO:0454539.7TNFSF11, PTH1R
18skeletal system developmentGO:0015019.7BGLAP, PTH1R, PTHLH
19response to activityGO:0148239.6TNF, BGLAP
20positive regulation of osteoclast differentiationGO:0456729.6TNFSF11, TNF
21response to mechanical stimulusGO:0096129.4TNF, BGLAP
22positive regulation of MAP kinase activityGO:0434069.3TNFSF11, TNF
23negative regulation of cell proliferationGO:0082859.3CYP27B1, TNF, PTH1R, PTHLH
24osteoclast differentiationGO:0303169.3TNFRSF11A, TNF, TNFSF11
25tumor necrosis factor-mediated signaling pathwayGO:0332099.3TNFSF11, TNF, TNFRSF11A
26ossificationGO:0015039.3CASR, TNFSF11, TNFRSF11A
27positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3TNFRSF11A, TNF, TNFSF11
28positive regulation of NF-kappaB transcription factor activityGO:0510929.2TNFSF11, TNF, TNFRSF11A
29positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.2TNFSF11, TNF, TNFRSF11A
30positive regulation of JNK cascadeGO:0463309.0TNFSF11, TNF

Molecular functions related to Humoral Hypercalcemia of Malignancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.3TNFSF11, TNF

Products for genes affiliated with Humoral Hypercalcemia of Malignancy

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4CDC
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