HD
MCID: HNT001
MIFTS: 85

Huntington's Disease (HD) malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Summaries for Huntington's Disease

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 35MedlinePlus, 45NINDS, 22Genetics Home Reference, 66Wikipedia, 48OMIM, 20GeneReviews, 34MalaCards
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NINDS:45 Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.

MalaCards: Huntington's Disease, also known as huntington disease, is related to motor neuron disease and schizophrenia, and has symptoms including cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy, eeg anomalies and movement disorder. An important gene associated with Huntington's Disease is HTT (huntingtin), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Apoptotic Pathways in Synovial Fibroblasts. The drugs baclofen and perphenazine and the compounds it 15 and axokine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are taste/olfaction and no phenotypic analysis.

Disease Ontology:9 A neurodegenerative disease that has material basis in expansion of cag repeats resulting in neuron degeneration affecting muscle coordination, cognitive abilities.

NIH Rare Diseases:44 Huntington diseaseĀ is a progressiveĀ disorder that causesĀ brain cell (neuron) degeneration in certain areas of the brain.Ā Ā this results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. symptoms typically appear between the ages of 35 and 44 years. people with huntington diseaseĀ most often live for 15 to 18 years after the condition appears. huntingtonĀ disease caused by mutations in the htt gene and is inherited in an autosomal dominantĀ manner. each child of a person with huntington diseaseĀ has a 50 percent (1 in 2) chance of inheriting theĀ mutation. there is also a less common, early-onset from that begins in childhood or adolescence, called juvenile huntington disease. last updated: 6/27/2011

MedlinePlus:35 Huntington's disease (hd) is an inherited disease that causes certain nerve cells in the brain to waste away. people are born with the defective gene, but symptoms usually don't appear until middle age. early symptoms of hd may include uncontrolled movements, clumsiness, and balance problems. later, hd can take away the ability to walk, talk, and swallow. some people stop recognizing family members. others are aware of their environment and are able to express emotions. if one of your parents has huntington's disease, you have a 50 percent chance of getting it. a blood test can tell you if have the hd gene and will develop the disease. genetic counseling can help you weigh the risks and benefits of taking the test. there is no cure. medicines can help manage some of the symptoms, but cannot slow down or stop the disease. nih: national institute of neurological disorders and stroke

Genetics Home Reference:22 Huntington disease is a progressive brain disorder that causes uncontrolled movements, emotional problems, and loss of thinking ability (cognition).

Wikipedia:66 Huntington\'s disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and... more...

Description from OMIM:48 143100

GeneReviews summary for huntington

Aliases & Classifications for Huntington's Disease

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Sources:
9Disease Ontology, 10diseasecard, 66Wikipedia, 20GeneReviews, 44NIH Rare Diseases, 21GeneTests, 23GTR, 22Genetics Home Reference, 45NINDS, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 36MeSH, 59SNOMED-CT, 28ICD9CM, 41NCIt, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
huntington disease:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age
juvenile huntington disease:
Inheritance: Autosomal dominant; Prevalence: 1-9/1000000; Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

huntington's disease 9 66 44 22 45 35 32
huntington disease 9 10 20 44 21 22 48 46 50 63
huntington chorea 20 23 22 50
huntington's chorea 9 44 22
juvenile huntington disease 50 63
hd 9 44
huntington chronic progressive hereditary chorea 22
progressive chorea, chronic hereditary 66
huntington's disease pathway 9
juvenile huntington chorea 50
huntingtons disease 11
jhd 50


External Ids:

Disease Ontology9 DOID:12858
MeSH36 D006816
ICD9CM28 333.4
OMIM48 143100
NCIt41 C82342
SNOMED-CT59 58756001, 155006000
MESH via Orphanet37 D006816
ICD10 via Orphanet27 G10
SNOMED-CT via Orphanet60 58756001, 230299004
UMLS via Orphanet64 C0020179, C0751208
ICD1026 G10

Related Diseases for Huntington's Disease

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Huntington's Disease family:

Huntington Disease-Like 2 Juvenile Huntington Disease
Huntington Disease-Like 1 Huntington Disease-Like Syndrome
Huntington Disease-Like 3 Huntington Disease-Like Syndrome Due to C9orf72 Expansions

Diseases related to Huntington's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1motor neuron disease30.4HTT, CNTF, BDNF
2schizophrenia30.3ATN1, HCRT, CNR1, CNTF, CALB1, TBP
3ischemia30.2BLVRB, HCRT, KMO, CNR1, CNTF, CASP1
4memory impairment30.1PRNP, CNR1, CALB1, BDNF
5prion disease30.1PRNP, HTT, CNR1, BDNF
6spinocerebellar ataxia30.0ATN1, PRNP, HTT, TBP
7dentatorubral-pallidoluysian atrophy30.0JPH3, ATN1, HTT, TBP
8spinocerebellar ataxia type 1730.0TBP, ATN1, JPH3
9glaucoma30.0BDNF, CNTF, CNR1
10dementia30.0HAP1, HCRT, PRNP, HTT, TBP, BDNF
11breast cancer29.8PFN1, HTT, CNR1, CASP8, CASP1, SLC2A3
12huntington disease-like 210.5
13huntington disease-like syndrome10.4
14huntington disease-like 110.3
15huntington disease-like 310.3
16huntington disease-like syndrome due to c9orf72 expansions10.3
17juvenile huntington disease10.3
18fragile x syndrome10.2
19parkinson's disease10.1BDNF, CNR1
20olivopontocerebellar atrophy10.1ATN1, HTT
21temporal lobe epilepsy10.1PRNP, CALB1, BDNF
22cannabis dependence10.1CNR1
23toxic encephalopathy10.1PRNP, HTT, BDNF
24neuroblastoma10.1BDNF, PRNP
25status epilepticus10.1BDNF, CNR1
26hereditary ataxia10.1ATN1, TBP
27spinocerebellar ataxia type 1210.1ATN1, PRNP, TBP
28spinocerebellar ataxia type 310.1TBP, HTT, ATN1
29eating disorder10.1HCRT, CNR1, BDNF
30psychotic disorder10.1CNR1, CNTF, BDNF
31obsessive-compulsive disorder10.1BDNF
32anorexia nervosa10.1BDNF, CNR1, HCRT
33progressive supranuclear palsy10.1HCRT, PRNP
34encephalitis10.1CNR1, CNTF, CALB1
35mood disorder10.1HCRT, CNR1, BDNF
36normal pressure hydrocephalus10.1
37hydrocephalus10.1
38ataxia10.1
39drug addiction10.1HCRT, BDNF
40bipolar disorder10.1CNR1, CALB1, BDNF
41cowpox10.1CASP1, CASP8
42herpes simplex10.1CASP1, CALB1, TBP, BDNF
43central nervous system disease10.1HCRT, CNR1, CNTF, BDNF
44cerebrovascular disease10.1CASP1, CNTF, CNR1, PRNP
45attention deficit hyperactivity disorder10.1
46neuronitis10.1
47conduct disorder10.1
48infectious mononucleosis10.1
49hypertension10.1
50pancreatitis10.1

Graphical network of the top 20 diseases related to Huntington's Disease:



Diseases related to huntington's disease

Symptoms for Huntington's Disease

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48OMIM, 50Orphanet
See all sources

Symptoms by clinical synopsis from OMIM:

143100

Clinical features from OMIM:

143100

Symptoms:

50 (show all 8)
  • cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy
  • eeg anomalies
  • movement disorder
  • hypertonia/spasticity/rigidity/stiffness
  • psychic/psychomotor regression/dementia/intellectual decline
  • psychic/behavioural troubles
  • autosomal dominant inheritance
  • abnormal cry/voice/phonation disorder/nasal speech

Drugs & Therapeutics for Huntington's Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Huntington's Disease

Drug clinical trials:

Search ClinicalTrials for Huntington's Disease

Search NIH Clinical Center for Huntington's Disease

Search CenterWatch for Huntington's Disease

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Huntington's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Huntington's Disease:
Embryonic stem cell-derived GABA progenitor cells for treatment of Huntington's disease
Embryonic/Adult Cultured Cells Related to Huntington's Disease:
Lateral Ganglionic Eminence progenitors, PMID: 22424902

Genetic Tests for Huntington's Disease

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Sources:
21GeneTests, 23GTR
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Genetic tests related to Huntington's Disease:

id Genetic test Affiliating Genes
1 Huntington Disease21 HTT
2 Huntington's Chorea23

Anatomical Context for Huntington's Disease

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
See all sources

MalaCards organs/tissues related to Huntington's Disease:

34
Brain, Testes, Cortex, Prefrontal cortex, Globus pallidus, Caudate nucleus, Heart, Breast, Thyroid, Skin, Pons, Pituitary, Cerebellum, Eye

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Huntington's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BrainStriatum  Affected by disease

Animal Models for Huntington's Disease or affiliated genes

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Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Huntington's Disease:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539410.1BDNF, CNR1, HTT
2MP:00030129.6ATN1, PRNP, HTT, CNR1, CNTF, TBP
3MP:00053899.5JPH3, ATN1, PRNP, HTT, CNR1, CASP1
4MP:00028739.5ATN1, SETDB1, PFN1, PRNP, HTT, CNR1
5MP:00107719.4HAP1, PFN1, HTT, CNR1, CASP8, CASP1
6MP:00053849.3SETDB1, PFN1, PRNP, HTT, CNR1, CNTF
7MP:00053809.2HAP1, SETDB1, PFN1, HTT, CASP8, TBP
8MP:00053789.0PFN1, HCRT, ATN1, JPH3, HAP1, PRNP
9MP:00053869.0HAP1, JPH3, ATN1, HCRT, PFN1, PRNP
10MP:00053769.0HTT, PRNP, PFN1, HCRT, HAP1, CNR1
11MP:00107688.9PFN1, SETDB1, ATN1, JPH3, HAP1, PRNP
12MP:00036318.6SLC2A3, HAP1, JPH3, ATN1, HCRT, SETDB1

Publications for Huntington's Disease

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Sources:
53PubMed
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Articles related to Huntington's Disease:

(show top 50)    (show all 1080)
idTitleAuthorsYear
1
Physical therapy in Huntington's disease--toward objective assessments? (22672573)
2013
2
Differential effects of early environmental enrichment on emotionality related behaviours in Huntington's disease transgenic mice. (23045340)
2013
3
Oral and dental health in Huntington's disease - an observational study. (24138900)
2013
4
Huntington's disease gene expansion associates with early onset nonprogressive chorea. (23536475)
2013
5
Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records. (23482661)
2013
6
Multiple Aspects of Gene Dysregulation in Huntington's Disease. (24167500)
2013
7
Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease. (24324398)
2013
8
Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells. (24041806)
2013
9
Dose-dependent neuroprotection of VEGFa88a88a88 in Huntington's disease striatum. (23799534)
2013
10
Functional magnetic resonance imaging of working memory in Huntington's disease: Cross-sectional data from the IMAGE-HD study. (23913754)
2013
11
Cognitive reserve and brain reserve in prodromal Huntington's Disease. (23702309)
2013
12
Noninvasive brain stimulation in Huntington's disease. (24112923)
2013
13
Neuroprotective effects of PPAR-I^ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease. (23373812)
2013
14
Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease. (22466800)
2012
15
High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model. (23346268)
2012
16
Network methods for describing sample relationships in genomic datasets: application to Huntington's disease. (22691535)
2012
17
Echolalia or functional repetition in conversation--a case study of an individual with Huntington's disease. (20831380)
2011
18
Huntington's disease presenting as posterior cortical atrophy. (21625777)
2011
19
Spermine improves recognition memory deficit in a rodent model of Huntington's disease. (19632348)
2009
20
Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. (19193873)
2009
21
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. (18558632)
2008
22
AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease. (18065778)
2008
23
Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease. (18192679)
2008
24
Early cognitive deficits in Swedish gene carriers of Huntington's disease. (17201528)
2007
25
Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. (17360721)
2007
26
Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain. (16487146)
2006
27
Short G-rich oligonucleotides as a potential therapeutic for Huntington's Disease. (17014717)
2006
28
Hypothalamic-endocrine aspects in Huntington's disease. (16925587)
2006
29
Purification of neuronal inclusions of patients with Huntington's disease reveals a broad range of N-terminal fragments of expanded huntingtin and insoluble polymers. (16181417)
2005
30
Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease. (16263095)
2005
31
Incidence and mutation rates of Huntington's disease in Spain: experience of 9 years of direct genetic testing. (15716522)
2005
32
Apolipoprotein E genotypes do not influence the age of onset in Huntington's disease. (15548484)
2004
33
Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease. (11870213)
2002
34
CAG mutation effect on rate of progression in Huntington's disease. (12548366)
2002
35
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease. (12165556)
2002
36
Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation. (12097329)
2002
37
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. (11988536)
2002
38
Wild-type huntingtin up-regulates BDNF transcription in Huntington's disease. (11697536)
2001
39
Benzodiazepine receptor quantification in Huntington's disease with [(123)I]omazenil and SPECT. (11309461)
2001
40
Transcriptional dysregulation in Huntington's disease. (10941183)
2000
41
The early cellular pathology of Huntington's disease. (10966117)
1999
42
Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin. (10434304)
1999
43
Huntington aggregates may not predict neuronal death in Huntington's disease. (10589536)
1999
44
The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. (9734812)
1998
45
A single allele from the polymorphic CCG rich sequence immediately 3' to the unstable CAG trinucleotide in the IT15 cDNA shows almost complete disequilibrium with Huntington's disease chromosomes in the Scottish population. (8162020)
1994
46
Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in disease prevalence. (7951324)
1994
47
A new polymerase chain reaction (PCR) assay for the trinucleotide repeat that is unstable and expanded on Huntington's disease chromosomes. (8366869)
1993
48
Brain muscarinic cholinergic receptors in Huntington's disease. (1532417)
1992
49
The psychopathology of Huntington's disease. (1825887)
1991
50
Synaptophysin expression in the striatum in Huntington's disease. (2141751)
1990

Variations for Huntington's Disease

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1 National Center for Biotechnology Information (Clinvar)
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Expression for genes affiliated with Huntington's Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Huntington's Disease

Search GEO for disease gene expression data for Huntington's Disease.

Pathways for genes affiliated with Huntington's Disease

About this section
Sources:
51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN
See all sources

Compounds for genes affiliated with Huntington's Disease

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 3BitterDB, 62Tocris Bioscience, 25HMDB
See all sources

Compounds related to Huntington's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1it 154610.5HTT, ATN1, JPH3
2axokine4610.5CNR1, CNTF, BDNF
3cystamine4610.4HTT, BDNF
4methamphetamine46 52 1212.3BDNF, CALB1, CNTF
5quinine46 30 3 52 1214.3BLVRB, KMO, BDNF
6amphetamine46 52 1212.3CNTF, CNR1, HCRT
7tetrodotoxin46 62 3012.2BDNF, CALB1, CNR1, HCRT
8cocaine46 1211.2HCRT, CNR1, CNTF, BDNF
9catecholamine4610.2BDNF, CNTF, HCRT, BLVRB
10glyceraldehyde 3-phosphate4610.2ATN1, PFN1, HTT, TBP
11n-acetylaspartate4610.2CALB1, BDNF
12thapsigargin46 6211.2HCRT, CNR1, CASP8, CASP1, BDNF
133-nitropropionic acid4610.1BDNF, HTT
14choline46 25 1212.1BDNF, CALB1, CNTF, BLVRB
15proline4610.1BDNF, TBP, HTT, PRNP, PFN1
16formaldehyde46 2511.1BLVRB, PRNP, CALB1, TBP
17kainate46 3011.1BLVRB, HTT, CNR1, CALB1, BDNF
18ethanol46 52 25 1213.1BLVRB, HCRT, CASP1, BDNF, SLC2A3
19n acetylcysteine4610.1BDNF, CASP1, CASP8, CNTF
20histamine46 30 2512.1HCRT, CNR1, CNTF, CASP1, BDNF
21melatonin46 30 62 25 1214.1BDNF, HTT, HCRT
22glutamine4610.0HAP1, ATN1, HTT, CASP1, TBP
23cycloheximide4610.0CNTF, CASP8, CASP1, BDNF, SLC2A3
24iron46 2511.0BDNF, TBP, HTT, PRNP, BLVRB
25norepinephrine46 25 1212.0HCRT, CNR1, CNTF, CALB1, BDNF
26superoxide46 2511.0BLVRB, PRNP, HTT, CNTF, CASP8, CASP1
27histidine4610.0TBP, CASP1, CNTF, PRNP
28h2o2469.9PRNP, CNTF, CASP8, CASP1, BDNF
29cyclic amp46 2510.9BDNF, TBP, CNTF, CNR1, HCRT
30gaba469.9BLVRB, HCRT, CNR1, CNTF, CALB1, BDNF
31acetylcholine46 52 30 25 1213.9BLVRB, HCRT, CNR1, CNTF, CALB1, BDNF
32adenylate469.9BLVRB, HCRT, CNR1, CNTF, TBP, BDNF
33octadecaneuropeptide469.8CNTF, HCRT
34alanine469.8HCRT, PRNP, HTT, CNR1, CNTF, CASP8
35retinoic acid46 2510.8HTT, CNTF, CASP8, CASP1, CALB1, TBP
36quinolinic acid46 2510.8BDNF, BLVRB, HCRT, KMO, HTT, CNTF
37cysteine469.8TBP, CASP1, CASP8, CNR1, HTT, ATN1
38nitric oxide46 25 1211.8BLVRB, HCRT, HTT, CNTF, CASP1, CALB1
39dopamine46 30 25 1212.8BLVRB, HCRT, HTT, CNR1, CNTF, CALB1
40lipid469.7HCRT, PFN1, PRNP, HTT, CNR1, CNTF
41potassium46 25 1211.7BLVRB, HCRT, CNTF, CASP1, CALB1, TBP
42serine469.7PRNP, HTT, CNR1, CNTF, CASP8, CASP1
43nmda46 3010.7BLVRB, HCRT, KMO, HTT, CNR1, CASP1
44oxygen46 2510.7BLVRB, KMO, PRNP, HTT, CASP8, CASP1
45testosterone46 62 25 1212.6ATN1, BLVRB, HCRT, HTT, CNTF, CASP1
46atp46 3010.5BLVRB, HCRT, PFN1, PRNP, HTT, CASP1
47calcium46 52 25 1212.4BLVRB, HCRT, PRNP, HTT, CNR1, CNTF
48glutamate469.4BLVRB, HCRT, KMO, PRNP, HTT, CNR1
49glucose469.3CNR1, HTT, HCRT, BLVRB, CNTF, CASP1
50tyrosine469.3PRNP, HCRT, BLVRB, ATN1, HTT, CNTF

GO Terms for genes affiliated with Huntington's Disease

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17Gene Ontology
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Cellular components related to Huntington's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:0057419.8KMO, PRNP, CASP8
2nucleusGO:0056348.9BLVRB, SETDB1, PFN1, PRNP, HTT, ZNF395
3cytoplasmGO:0057378.5SLC2A4RG, ATN1, BLVRB, SETDB1, PRNP, HTT

Biological processes related to Huntington's Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1quinolinate biosynthetic processGO:01980510.4KMO, HTT
2regulation of retinal cell programmed cell deathGO:04666810.4BDNF, CNTF
3vesicle transport along microtubuleGO:04749610.3HTT, HAP1
4learning or memoryGO:00761110.2BDNF, CALB1, PRNP
5execution phase of apoptosisGO:09719410.2CASP1, CASP8
6negative regulation of neuron apoptotic processGO:04352410.2HTT, CNTF, BDNF
7response to lipopolysaccharideGO:03249610.0CNR1, CASP8, CASP1
8cellular response to organic substanceGO:07131010.0CALB1, CASP1
9regulation of excitatory postsynaptic membrane potentialGO:0600799.9BDNF, HCRT

Products for genes affiliated with Huntington's Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Huntington's Disease

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet