HD
MCID: HNT001
MIFTS: 86

Huntington's Disease (HD) malady

Neuronal diseases category

Summaries for Huntington's Disease

About this section
Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NINDS:43 Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.

MalaCards: Huntington's Disease, also known as huntington disease, is related to huntington disease-like 2 and motor neuron disease, and has symptoms including cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy, eeg anomalies and movement disorder. An important gene associated with Huntington's Disease is HTT (huntingtin), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Apoptotic Pathways in Synovial Fibroblasts. The drugs baclofen and perphenazine and the compounds atp and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are nervous system and mortality/aging.

Disease Ontology:8 A neurodegenerative disease that has material basis in expansion of cag repeats resulting in neuron degeneration affecting muscle coordination, cognitive abilities.

Genetics Home Reference:21 Huntington disease is a progressive brain disorder that causes uncontrolled movements, emotional problems, and loss of thinking ability (cognition).

NIH Rare Diseases:42 Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain.  this results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. symptoms typically appear between the ages of 35 and 44 years. people with huntington disease most often live for 15 to 18 years after the condition appears. huntington disease caused by mutations in the htt gene and is inherited in an autosomal dominant manner. each child of a person with huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. there is also a less common, early-onset from that begins in childhood or adolescence, called juvenile huntington disease. last updated: 6/27/2011

MedlinePlus:33 Huntington's disease (hd) is an inherited disease that causes certain nerve cells in the brain to waste away. people are born with the defective gene, but symptoms usually don't appear until middle age. early symptoms of hd may include uncontrolled movements, clumsiness, and balance problems. later, hd can take away the ability to walk, talk, and swallow. some people stop recognizing family members. others are aware of their environment and are able to express emotions. if one of your parents has huntington's disease, you have a 50 percent chance of getting it. a blood test can tell you if have the hd gene and will develop the disease. genetic counseling can help you weigh the risks and benefits of taking the test. there is no cure. medicines can help manage some of the symptoms, but cannot slow down or stop the disease. nih: national institute of neurological disorders and stroke

Wikipedia:63 Huntington\'s disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and... more...

Description from OMIM:46 143100

GeneReviews summary for huntington

Aliases & Classifications for Huntington's Disease

About this section
Sources:
8Disease Ontology, 63Wikipedia, 42NIH Rare Diseases, 21Genetics Home Reference, 43NINDS, 33MedlinePlus, 30LifeMap Discovery™, 9diseasecard, 19GeneReviews, 20GeneTests, 46OMIM, 44Novoseek, 48Orphanet, 60UMLS, 22GTR, 10DISEASES, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
huntington disease:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age
juvenile huntington disease:
Inheritance: Autosomal dominant; Prevalence: 1-9/1000000; Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

huntington's disease 8 63 42 21 43 33 30
huntington disease 9 19 42 20 21 46 44 48 60
huntington chorea 19 22 21 48
huntington's chorea 8 42 21
juvenile huntington disease 48 60
hd 8 42
huntington chronic progressive hereditary chorea 21
progressive chorea, chronic hereditary 63
huntington's disease pathway 8
juvenile huntington chorea 48
huntingtons disease 10
jhd 48


External Ids:

Disease Ontology8 DOID:12858
ICD9CM27 333.4
MeSH34 D006816
OMIM46 143100
NCIt39 C82342
SNOMED-CT56 58756001, 155006000
MESH via Orphanet35 D006816
ICD10 via Orphanet26 G10
SNOMED-CT via Orphanet57 58756001, 230299004
UMLS via Orphanet61 C0020179, C0751208
ICD1025 G10

Related Diseases for Huntington's Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Huntington's Disease family:

Huntington Disease-Like 2 Juvenile Huntington Disease
Huntington Disease-Like 1 Huntington Disease-Like Syndrome
Huntington Disease-Like 3

Diseases related to Huntington's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1huntington disease-like 230.8JPH3
2motor neuron disease30.1HTT, BDNF
3ischemia30.0BDNF, CASP1, CASP2, KMO, SETD2
4pancreatitis30.0CASP1
5dementia29.9BDNF, HTT, HAP1, PRNP
6dentatorubral-pallidoluysian atrophy29.9PRNP, JPH3, HTT
7prion disease29.9BDNF, HTT, PRNP
8breast cancer29.8CASP1, CASP8, CASP2, HTT, PFN1, SETD2
9brain disease10.5
10huntington disease-like 110.3
11huntington disease-like 310.3
12chromosomal disease10.2
13juvenile huntington disease10.2
14fragile x syndrome10.1
15schizophrenia10.1
16normal pressure hydrocephalus10.1
17hydrocephalus10.1
18attention deficit hyperactivity disorder10.0
19conduct disorder10.0
20neuronitis10.0
21infectious mononucleosis10.0
22hypertension10.0
23b cell deficiency10.0
24malaria10.0
25alzheimer's disease10.0BDNF, CASP1, CALB1, CASP2, HTT, PRNP
26parkinson's disease10.0BDNF, CASP8, CALB1, HTT, PRNP
27amyotrophic lateral sclerosis10.0BDNF, CASP1, HTT, PRNP
28astrocytoma10.0CASP8, CASP2, PRNP, SETD2
29epilepsy syndrome10.0BDNF, CALB1, CASP2, PRNP
30toxic encephalopathy10.0BDNF, HTT, PRNP
31memory impairment10.0PRNP, CALB1, BDNF
32temporal lobe epilepsy10.0BDNF, CALB1, PRNP
33multiple sclerosis10.0CASP8, CASP1, BDNF
34pancreatic cancer10.0BDNF, CASP1, CASP8, SETD2
35multiple system atrophy10.0PRNP, HTT
36colon cancer10.0CASP1, CASP8, SETD2
37ovarian cancer10.0SETD2, CASP2, CASP8, CASP1
38neuroblastoma10.0PRNP, BDNF
39encephalitis10.0CALB1
40machado-joseph disease9.9
41cerebritis9.9
42hereditary spastic paraplegia9.9
43leber hereditary optic neuropathy9.9
44lipoid proteinosis9.9
45chorea-acanthocytosis9.9
46breast disease9.9
47cerebellar disease9.9
48myotonic disease9.9
49myotonic dystrophy9.9
50paraplegia9.9

Graphical network of the top 20 diseases related to Huntington's Disease:



Diseases related to huntington's disease

Clinical Features for Huntington's Disease

About this section
Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

143100

Clinical synopsis from OMIM:

143100

Symptoms:

48 (show all 8)
  • cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy
  • eeg anomalies
  • movement disorder
  • hypertonia/spasticity/rigidity/stiffness
  • psychic/psychomotor regression/dementia/intellectual decline
  • psychic/behavioural troubles
  • autosomal dominant inheritance
  • abnormal cry/voice/phonation disorder/nasal speech

Drugs & Therapeutics for Huntington's Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Huntington's Disease

Drug clinical trials:

Search ClinicalTrials for Huntington's Disease

Search NIH Clinical Center for Huntington's Disease

Search CenterWatch for Huntington's Disease

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Huntington's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Huntington's Disease:
Embryonic stem cell-derived GABA progenitor cells for treatment of Huntington's disease
Embryonic/Adult Cultured Cells Related to Huntington's Disease:
Lateral Ganglionic Eminence progenitors, PMID: 22424902

Genetic Tests for Huntington's Disease

About this section
Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Huntington's Disease:

id Genetic test Affiliating Genes
1 Huntington Disease20 HTT
2 Huntington's Chorea22

Anatomical Context for Huntington's Disease

About this section
Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Huntington's Disease:

32
Brain, Testes, Cortex, Prefrontal cortex, Globus pallidus, Caudate nucleus, Heart, Breast, Skin, Thyroid, Pons, Pituitary, Cerebellum, Eye

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Huntington's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BrainStriatum  Affected by disease

Animal Models for Huntington's Disease or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Huntington's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363112.9SETD2, BDNF, CASP1, CASP8, CALB1, CASP2
2MP:001076812.5BDNF, CASP1, CASP8, CASP2, HTT, HAP1
3MP:000538412.0BDNF, CASP1, CASP8, CASP2, UBE2K, HTT
4MP:000537612.0CASP1, CASP8, HTT, HAP1, PRNP, HIP1
5MP:000537811.9BDNF, CASP8, HTT, HAP1, JPH3, PRNP
6MP:000538911.7BDNF, CASP1, CASP2, HTT, JPH3, PRNP
7MP:000538611.5BDNF, CALB1, HTT, HAP1, JPH3, PRNP

Publications for Huntington's Disease

About this section
Sources:
50PubMed
See all sources

Articles related to Huntington's Disease:

(show top 50)    (show all 1109)
idTitleAuthorsYear
1
A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice. (24278347)
2013
2
Chemical screening platforms for autophagy drug discovery to identify therapeutic candidates for Huntington's disease and other neurodegenerative disorders. (24050242)
2013
3
Neuroprotective effects of psychotropic drugs in Huntington's disease. (24248060)
2013
4
A Tale of Two Maladies? Pathogenesis of Depression with and without the Huntington's Disease Gene Mutation. (23847583)
2013
5
Aripiprazole treatment for choreoathetoid and psychotic symptoms of Huntington's disease. (23686053)
2013
6
Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease. (23746982)
2013
7
Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models. (23616545)
2013
8
Expression of expanded CAG transcripts triggers nucleolar stress in Huntington's disease. (23315009)
2013
9
Effectiveness of intensive neurorehabilitation in patients with Huntington's disease. (23480977)
2013
10
Elevated arteriolar cerebral blood volume in prodromal Huntington's disease. (23847161)
2013
11
Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease. (22466800)
2012
12
The Prevalence of Juvenile Huntington's Disease: A Review of the Literature and Meta-Analysis. (22953238)
2012
13
"Huntingtin holiday": progress toward an antisense therapy for Huntington's disease. (22726826)
2012
14
Huntington's disease: fighting on many fronts. (22427330)
2012
15
Does Huntington's disease enhance cephalad spread during neuraxial anesthesia for cesarean section? (22986328)
2012
16
The expanding world of stem cell modeling of Huntington's disease: creating tools with a promising future. (22943447)
2012
17
Coexistence of Huntington's disease and amyotrophic lateral sclerosis: a clinicopathologic study. (22735976)
2012
18
RNAi-based therapies for Huntington's disease: delivery challenges and opportunities. (23035592)
2012
19
Altered ventral striatal activation during reward and punishment processing in premanifest Huntington's disease: a functional magnetic resonance study. (22366326)
2012
20
Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression. (22996692)
2012
21
Anaesthesia and orphan disease: sugammadex in a patient with Huntington's disease undergoing thyroid lobectomy. (22935957)
2012
22
Influence of species differences on the neuropathology of transgenic Huntington's disease animal models. (22749010)
2012
23
Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease. (22953237)
2012
24
Brain-derived neurotrophic factor in patients with Huntington's disease. (21857974)
2011
25
Validating the use of M4-BAC-GFP mice as tissue donors in cell replacement therapies in a rodent model of Huntington's disease. (21295605)
2011
26
Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease. (21546905)
2011
27
Selection of behaviors and segmental coordination during larval locomotion is disrupted by nuclear polyglutamine inclusions in a new Drosophila Huntington's disease-like model. (21087194)
2010
28
Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset. (19465745)
2009
29
Association of corticobasal degeneration and Huntington's disease: can Tau aggregates protect Huntingtin toxicity? (19243029)
2009
30
Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease. (18192679)
2008
31
Glutamate uptake is reduced in prefrontal cortex in Huntington's disease. (17726644)
2008
32
Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice. (18805465)
2008
33
Huntington's disease--like 2 is associated with CUG repeat-containing RNA foci. (17387722)
2007
34
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. (17392473)
2007
35
Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice. (16647250)
2006
36
Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease? (16990826)
2006
37
Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease. (16204350)
2005
38
Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease. (15967379)
2005
39
Retrograde amnesia in dementia: comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease. (15506837)
2004
40
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease. (12165556)
2002
41
Reduction of glyceraldehyde-3-phosphate dehydrogenase activity in Alzheimer's disease and in Huntington's disease fibroblasts. (11208907)
2001
42
Chemical anatomy of striatal interneurons in normal individuals and in patients with Huntington's disease. (11086188)
2000
43
Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice. (10891614)
2000
44
Cervical dystonia: the initial presentation of Huntington's disease? (9235492)
1997
45
A case of Klippel-Trenaunay syndrome associated with Huntington's disease. (9339642)
1997
46
Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia. (9153527)
1997
47
Genetic screening for Huntington's disease in Chinese patients with involuntary movements. (9491297)
1997
48
Molecular re-investigation of patients with Huntington's disease in Wessex reveals a family with dentatorubral and pallidoluysian atrophy. (8557266)
1996
49
Glucose transporter isoform expression in Huntington's disease brain. (7931291)
1994
50
Dementia in Huntington's disease is associated with neurochemical deficits in the caudate nucleus, not the cerebral cortex. (1973277)
1990

Genetic Variations for Huntington's Disease

About this section

Expression for genes affiliated with Huntington's Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Huntington's Disease

Search GEO for disease gene expression data for Huntington's Disease.

Pathways for genes affiliated with Huntington's Disease

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 55SinoBiological, 12EMD Millipore
See all sources

Pathways related to Huntington's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2HIP1, HAP1, HTT, CASP8, BDNF
2
Hide members
11.2PFN1, CASP2, CASP8, CASP1, BDNF
3
Hide members
11.1BDNF, CASP1, CASP8, CASP2
4
Hide members
10.9CASP2, CASP8, CASP1
5
Hide members
10.9CASP2, CASP8, CASP1
6
Hide members
10.9CASP1, CASP8, CASP2
7
Hide members
10.9CASP2, CASP8, CASP1
810.9CASP2, CASP8, CASP1
9
Hide members
10.9CASP1, CASP8, CASP2
10
Apoptosis and survival Caspase cascade
Hide members
10.9CASP2, CASP8, CASP1

Compounds for genes affiliated with Huntington's Disease

About this section
Sources:
44Novoseek, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB
See all sources

Compounds related to Huntington's Disease according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1atp44 2813.3BDNF, CASP1, CALB1, CASP2, UBE2K, HTT
2tyrosine4412.2BDNF, CASP1, CASP8, CALB1, UBE2K, HTT
3oxygen44 2413.1BDNF, CASP1, CASP8, CASP2, HTT, PRNP
4lipid4412.1BDNF, CASP1, CASP2, HTT, PRNP, HIP1
5h2o24412.0BDNF, CASP1, CASP8, CASP2, UBE2K, PRNP
6retinoic acid44 2412.9BDNF, CASP1, CASP8, CALB1, CASP2, HTT
7superoxide44 2412.8CASP1, CASP8, CASP2, HTT, PRNP, SETD2
8testosterone44 59 11 2414.8BDNF, CASP1, CALB1, CASP2, HTT, SETD2
9glutamate4411.7BDNF, CASP1, CALB1, HTT, PRNP, KMO
10serine4411.7BDNF, CASP1, CASP8, CASP2, HTT, PRNP
11quinolinic acid44 2412.7KMO, QPRT, HTT, CALB1, BDNF
12camptothecin44 59 1113.7BDNF, CASP1, CASP8, CASP2, SETD2
13butyrate4411.6CASP1, CASP8, CASP2, HTT, SETD2
14paclitaxel44 49 1113.6BDNF, CASP1, CASP8, CASP2, SETD2
15cysteine4411.6CASP1, CASP8, CASP2, UBE2K, HTT, DNAJC5
16doxorubicin44 49 1113.6BDNF, CASP1, CASP8, CASP2, SETD2
17actinomycin d4411.6BDNF, CASP1, CASP8, UBE2K, SETD2
18glucose4411.6BDNF, CASP1, CALB1, HTT, SLC2A4RG, SETD2
19proline4411.6SETD2, PFN1, PRNP, HTT, BDNF
20glutamine4411.6CASP1, CASP2, HTT, HAP1, HIP1
21cisplatin44 49 59 1114.6BDNF, CASP1, CASP8, CASP2, SETD2
22nmda44 2812.5KMO, HTT, CASP1, BDNF
23arsenite44 2412.5CASP1, CASP8, CASP2, SETD2
24etoposide44 49 59 1114.4SETD2, CASP2, CASP8, CASP1
25n acetylcysteine4411.4BDNF, CASP1, CASP8, SETD2
26sb 20358044 5912.4SETD2, PRNP, CASP8, CASP1
27z-dqmd-fmk59 2812.4CASP1, CASP8, CASP2
28az 104178085911.4CASP1, CASP8, CASP2
29z-devd-fmk59 2812.4CASP1, CASP8, CASP2
30z-vad-fmk44 5912.3CASP1, CASP8, CASP2
31mevalonate4411.3CASP1, CASP8, CASP2
32tetrapeptide4411.3CASP1, CASP8, CASP2
33melatonin44 59 28 11 2415.2BDNF, CASP2, HTT
34tetracycline44 1112.2PRNP, CASP8, CASP1
35anisomycin44 1112.2BDNF, CASP1, CASP8
36it 154411.2JPH3, HTT
37adpribose4411.1CASP2, CASP8, CASP1
38pd 98,0594411.1BDNF, CASP1, CASP8, SETD2
39cystamine4411.1HTT, BDNF
40kainate44 2812.1BDNF, CALB1, HTT
41n-acetylaspartate4411.1CALB1, BDNF
423-nitropropionic acid4411.1BDNF, HTT
43sp 60012544 5912.1SETD2, CASP2, CASP8
44wortmannin4411.1BDNF, CASP8, CASP2, SETD2
45potassium44 11 2413.1CASP2, CALB1, CASP1, BDNF
46lead4411.0SETD2, CASP2, BDNF
47oligonucleotide4410.9CASP1, CALB1, CASP2, HTT, SETD2
48sodium nitroprusside4410.8SETD2, CASP8, CASP1

GO Terms for genes affiliated with Huntington's Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Huntington's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.1CALB1, CASP2, HTT, PRNP, HIP1, PFN1
2cytoskeletonGO:00585610.8PFN1, HIP1, HAP1, CASP8

Biological processes related to Huntington's Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1learning or memoryGO:00761111.1PRNP, CALB1, BDNF
2cellular response to mechanical stimulusGO:07126011.1CASP1, CASP8, CASP2
3activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691911.0HIP1, CASP8, CASP1
4quinolinate biosynthetic processGO:01980511.0KMO, HTT
5vesicle transport along microtubuleGO:04749610.8HTT, HAP1
6negative regulation of neuron apoptotic processGO:04352410.8BDNF, HTT, DNAJC5
7NAD biosynthetic processGO:00943510.8KMO, QPRT
8cellular response to organic substanceGO:07131010.8CALB1, CASP1
9apoptotic signaling pathwayGO:09719010.6HIP1, CASP2, CASP8

Molecular functions related to Huntington's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.3UBE2K, CASP2, CALB1, CASP8, HTT, HAP1
2cysteine-type endopeptidase activityGO:00419710.8CASP2, CASP8, CASP1
3ATP-dependent protein bindingGO:04300810.5DNAJC5, PRNP

Products for genes affiliated with Huntington's Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Huntington's Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet