Huntington's Disease malady

NINDS: Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.³¹

MalaCards: Huntington's Disease, also known as huntington disease, is related to neuronitis and carcinoma. An important gene associated with Huntington's Disease is HTT (huntingtin), and among its related pathways are Endocrine and other factor-regulated calcium reabsorption and Transcription Ligand-Dependent Transcription of Retinoid-Target genes. The drugs baclofen and coenzyme q10 and the compounds nmda and calcium have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are nervous system and mortality/aging.

Disease Ontology: A neurodegenerative disease that has material basis in expansion of cag repeats resulting in neuron degeneration affecting muscle coordination, cognitive abilities.⁶

NIH Rare Diseases: Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain.  This results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. Symptoms typically appear between the ages of 35 and 44 years. People with Huntington disease most often live for 15 to 18 years after the condition appears. Huntington disease caused by mutations in the HTT gene and is inherited in an autosomal dominant manner. Each child of a person with Huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. There is also a less common, early-onset from that begins in childhood or adolescence, called juvenile Huntington disease.³⁰

MedlinePlus: Huntington's disease (hd) is an inherited disease that causes certain nerve cells in the brain to waste away. people are born with the defective gene, but symptoms usually don't appear until middle age. early symptoms of hd may include uncontrolled movements, clumsiness or balance problems. later, hd can take away the ability to walk, talk or swallow. some people stop recognizing family members. others are aware of their environment and are able to express emotions. if one of your parents has huntington's disease, you have a 50-50 chance of getting it. a blood test can tell if you have the hd gene and will develop the disease. genetic counseling can help you weigh the risks and benefits of taking the test. there is no cure. medicines can help manage some of the symptoms, but cannot slow down or stop the disease. nih: national institute of neurological disorders and stroke²³

Genetics Home Reference: Huntington disease is a progressive brain disorder that causes uncontrolled movements, emotional problems, and loss of thinking ability (cognition).¹⁷

Wikipedia: Huntington's disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and...⁴⁴ more...

OMIM: 143100

GeneReviews summary for huntington

Aliases & Descriptions:

huntington's disease 6 44 30 17 31 23 huntington disease 7 15 30 16 17 33 32 43 hd 6 30 16 progressive chorea, chronic hereditary (huntington) 44 17 huntington's chorea 6 30

huntington chorea 15 16 huntington's chorea (disorder) 6 huntington's disease pathway 6 huntingtons disease 8 progressive chorea 43

Diseases related to huntington's disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 621)

id	Related Disease	Score	Top Affiliating Genes
1	neuronitis	70.3	ZNF395, PIK3R3, PIK3R2, PIK3R1, SH3GL3, NCOR1
2	carcinoma	60.6	PIK3R3, PIK3R2, PIK3R1, SH3BP2, NCOR1, NCOR2
3	neurodegeneration	54.8	SGK1, CNR1, CNTF, RCAN1, VPS13A, SETD2
4	cerebritis	52.8	PIK3R1, REST, SGK1, CNR1, CNTF, SETD2
5	neurodegenerative disease	50.1	CNR1, CNTF, VPS13A, SETD2, SERPINI1, SERPINA3
6	leukemia	48.9	PIK3R3, PIK3R2, PIK3R1, PIAS4, SH3BP2, SH3GL3
7	ischemia	48.7	SGK1, CNR1, CNTF, SETD2, SERPINI1, VIM
8	retinitis	48.3	PDC, SGK1, CNR1, CNTF, KIAA1377, SETD2
9	parkinson's disease	47.7	CNR1, CNTF, SERPINA3, NAT2, BLVRB, PAWR
10	pancreatitis	47.7	PIK3R3, PIK3R2, PIK3R1, REST, SGK1, CNR1
11	breast cancer	47.2	PIK3R2, PIK3R1, NCOR1, NCOR2, REST, SGK1
12	ataxia	47.1	PIK3R1, SH3GL3, NCOR1, PCM1, SETDB1, SETD2
13	dementia	46.5	SERPINI1, SERPINA3, NAT2, BLVRB, BDNF, SDHB
14	cholesterol	45.1	PIK3R2, PIK3R1, NCOR1, NCOR2, SGK1, CNR1
15	neuropathy	40.2	CNR1, CNTF, VPS13A, VIM, PARP1, BDNF
16	colon cancer	38.6	PIK3R3, PIK3R1, NCOR2, CNR1, BTRC, SETD2
17	multiple system atrophy	38.6	SERPINA3, RAB3A, RAB5A, BDNF, CHAT, UCHL1
18	huntington disease-like	37.8	ATN1, JPH3, HTT, TBP, PRNP, HLN2
19	fibrosis	37.7	SGK1, CNR1, SETD2, SERPINA3, VIM, NAT2
20	diabetes mellitus	37.3	PIK3R3, PIK3R2, PIK3R1, SGK1, CNR1, SERPINA3
21	breast carcinoma	37.2	PIK3R1, NCOR1, SETD2, SERPINA3, VIM, NAT2
22	infertility	36.9	SGK1, VDAC1, VDAC3, UTP14A, BLVRB, BDNF
23	lymphoblastic leukemia	36.6	NAT2, VDAC1, RAB6A, RAN, PAWR, PARP1
24	chorea	36.4	VPS13A, BDNF, XK, ATN1, FXN, JPH3
25	blindness	36.3	CNR1, CNTF, LEP, MTHFR, ATXN7, CD79A
26	myeloid leukemia	36.1	PIK3R3, PIK3R2, PIK3R1, PIAS4, NCOR1, NCOR2
27	sarcoma	35.7	ZNF395, PIK3R2, PIK3R1, PIAS4, SETD2, SERPINA3
28	hypertension	35.6	PIK3R1, PDC, SGK1, CNR1, SETD2, SERPINA3
29	muscular dystrophy	35.2	PIAS4, VIM, CKB, CHERP, UBC, MT-CYB
30	dentatorubral-pallidoluysian atrophy	35.1	ATN1, HTT, CASP3, CACNA1A, CALB2, TPH1
31	cystic fibrosis	34.7	SGK1, SERPINA3, NAT2, VDAC1, UQCRC1, LEP
32	pick's disease	34.6	BDNF, CKB, CHAT, UCHL1, GRM1, APOE
33	myotonic dystrophy	34.5	VIM, CKB, LEP, ATXN3, ATXN1, CDC42
34	alzheimer's disease	34.4	APOE, APP, MAPT, PSEN1, PSEN2, PRNP
35	cerebellar ataxia	34.3	SH3GL3, PCM1, KCNC3, ATXN3, ATXN1, ATN1
36	neurologic diseases	34.2	CNTF, PARP1, CKB, AR, IL2RA, APOE
37	myeloma	33.5	PIK3R2, PIK3R1, NCOR2, SGK1, CNTF, SETD2
38	lewy body dementia	33.3	CDK5, APOE, APP, MAPT, MAOB, SNCA
39	schizophrenia	32.9	MTHFR, KALRN, FEZ1, MAOA, AKT1, DRD2
40	spinocerebellar ataxia type 17	32.9	ATXN3, ATXN1, ATN1, ATXN7, JPH3, CACNA1A
41	friedreich ataxia	32.6	ATXN3, ATXN1, FXN, FMR1, GSR, IDUA
42	fragile x syndrome	32.5	BDNF, ATN1, FMR1, GRIK1, GRM1, GRM5
43	myoclonus	32.5	SERPINI1, SDHB, UBC, MT-CO2, ATN1, CDKN3
44	acute myeloid leukemia	32.5	PIK3R3, PIK3R2, PIK3R1, NCOR1, NCOR2, PCM1
45	peripheral neuropathy	32.5	CNTF, VPS13A, BDNF, MTHFR, MT-CO3, MT-CYB
46	multiple myeloma	32.0	PIK3R2, PIK3R1, NCOR2, CNTF, SETD2, NAT2
47	prostatitis	31.6	PIK3R3, PIK3R2, PIK3R1, PIAS4, NCOR1, NCOR2
48	spinocerebellar ataxia type 3	31.5	CHERP, UBC, ATXN3, ATXN1, HSPB1, SOD2
49	acanthocytosis	31.5	VPS13A, XK, JPH3, GNA14, GNAQ, RPS27A
50	convulsions	31.3	BLVRB, BDNF, SDHB, CDK5R1, GRM5, APOE

Clinical features from OMIM: 143100

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 baclofen, coenzyme q10, perphenazine, pimozide

Cell-based therapeutics:

Lateral Ganglionic Eminence progenitors, PMIDs: 22424902

Genetic tests related to huntington's disease:

id	Genetic test	Affiliating Genes
1	Huntington's Disease clinical/research	HTT

MalaCards organs/tissues related to huntington's disease:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Brain -> Striatum	Affected by disease

MGI Mouse Phenotypes related to huntington's disease:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system phenotype	MP:0003631	26.1	SH3BP2, NCOR1, PDC, REST, CNR1, CNTF
2	mortality/aging	MP:0010768	24.8	PIAS4, SH3BP2, NCOR1, NCOR2, REST, CNR1
3	behavior/neurological phenotype	MP:0005386	24.6	NCOR1, NCOR2, PDE10A, PDE1B, CNR1, CNTF
4	homeostasis/metabolism phenotype	MP:0005376	23.1	PIK3R2, PIK3R1, SH3BP2, NCOR1, NCOR2, PDC
5	cellular phenotype	MP:0005384	22.0	PIK3R1, SH3BP2, NCOR1, NCOR2, REST, CNR1
6	growth/size phenotype	MP:0005378	21.9	PIK3R1, NCOR1, NCOR2, PDE10A, REST, SGK1
7	normal phenotype	MP:0002873	18.1	PIK3R1, SETDB1, RAB3A, PAWR, BDNF, SDHD
8	vision/eye phenotype	MP:0005391	16.5	SH3BP2, PDC, REST, VIM, BDNF, BCL11B
9	cardiovascular system phenotype	MP:0005385	16.3	PIK3R2, PIK3R1, NCOR2, PDC, RCAN1, SETD2
10	integument phenotype	MP:0010771	16.2	SH3BP2, NCOR1, CNR1, BECN1, PARP1, BDNF
11	reproductive system phenotype	MP:0005389	16.0	RCAN1, BTRC, VDAC3, BECN1, LEP, ZBTB16
12	muscle phenotype	MP:0005369	15.9	PIK3R2, PIK3R1, SH3BP2, NCOR1, PDC, CNTF
13	immune system phenotype	MP:0005387	15.4	PIAS4, NCOR1, CNTF, RCAN1, BTRC, VIM
14	hematopoietic system phenotype	MP:0005397	15.4	PIAS4, SH3BP2, CNTF, RCAN1, VPS13A, BTRC
15	embryogenesis phenotype	MP:0005380	15.1	NCOR1, REST, SETDB1, SETD2, VIM, BECN1
16	respiratory system phenotype	MP:0005388	14.7	SH3BP2, VDAC3, RAB3A, RAI1, BDNF, MSX1
17	skeleton phenotype	MP:0005390	14.6	SH3BP2, CNR1, RAI1, LEP, ZBTB16, CHAT
18	no phenotypic analysis	MP:0003012	14.3	PIK3R1, REST, SGK1, CNR1, PARP1, BDNF
19	digestive/alimentary phenotype	MP:0005381	14.1	SH3BP2, NCOR2, BDNF, LEP, UCHL1, YAP1
20	endocrine/exocrine gland phenotype	MP:0005379	13.9	RCAN1, ZBTB16, YAP1, MSX1, ATG16L1, ATN1
21	liver/biliary system phenotype	MP:0005370	13.4	SH3BP2, NCOR1, NCOR2, YAP1, SAFB, ATF6
22	renal/urinary system phenotype	MP:0005367	12.9	PDC, SGK1, UCHL1, BAX, MTSS1, AXIN1
23	hearing/vestibular/ear phenotype	MP:0005377	12.6	PARP1, BDNF, KCNAB2, BAX, AXIN1, MSX1
24	craniofacial phenotype	MP:0005382	12.1	SH3BP2, NCOR2, RAI1, BDNF, BCL11B, MSX1
25	limbs/digits/tail phenotype	MP:0005371	12.0	RAI1, LEP, ZBTB16, UCHL1, BAX, MTHFR
26	taste/olfaction phenotype	MP:0005394	11.8	CNR1, BDNF, ENO2, MAPT, HTT, GNAL
27	tumorigenesis	MP:0002006	10.9	PIK3R2, PIK3R1, RCAN1, BTRC, BECN1, BCL11B
28	adipose tissue phenotype	MP:0005375	10.7	PIK3R1, NCOR1, NCOR2, CNR1, RAI1, LEP

Articles related to huntington's disease:

(show top 50)    (show all 597)

id	Title	Authors	Year	Affiliating Genes
1	Nuclear translocation of AMPK-alpha1 potentiates stri atal neurodegeneration in Huntington's disease. (21768291)	Ju T.C.... Chern Y.	2011	PRKAA1
2	Age at onset in Huntington's disease: replication stu dy on the associations of ADORA2A, HAP1 and OGG1. (20512606)	Taherzadeh-Fard E.... Arning L.	2010	OGG1, ADORA2A, HAP1
3	Selection of behaviors and segmental coordination dur ing larval locomotion is disrupted by nuclear polyglutamine inclusions in a new Drosophila Huntington's disease-like model. (21087194)	Nishimura Y.... Morimoto T.	2010	HTT
4	Huntington disease in subjects from an Israeli Karaite community carrying alleles of intermediate and expanded CAG repeats in the HTT gene: Huntington disease or phenocopy? (19059613)	Herishanu Y.O.... Squitieri F.	2009	HTT
5	Neuropsychological deficits in Huntington's disease gene carriers and correlates of early 'conversion'. (19196932)	Brandt J.... Ross C.A.	2008	HTT
6	Towards a transgenic model of Huntington's disease in a non-human primate. (18488016)	Yang S.H.... Chan A.W.	2008	HTT
7	Effect of CAG repeat length on psychiatric disorders in Huntington's disease. (17610899)	Vassos E.... Vassilopoulos D.	2008	HTT
8	Huntington disease mutation in Venezuela: age of onset, haplotype analyses and geographic aggregation. (18157708)	Paradisi I.... Arias S.	2008	HTT
9	Selective degeneration in YAC mouse models of Huntington disease. (17352936)	Van Raamsdonk J.M.... Hayden M.R.	2007	HTT
10	The Huntington's disease-like syndromes: what to consider in patients with a negative Huntington's disease gene test. (17805246)	Schneider S.A.... Bhatia K.P.	2007	JPH3, HTT
11	Intergeneration CAG expansion in a Wuhan juvenile-onset Huntington disease family. (17687393)	Liu Y.... Tang Y.P.	2007	HTT
12	Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. (17055784)	Weydt P.... La Spada A.R.	2006	HTT
13	A novel population of progenitor cells expressing cannabinoid receptors in the subependymal layer of the adult normal and Huntington's disease human brain. (16533591)	Curtis M.A.... Glass M.	2006	CNR1
14	Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease. (16183657)	Benn C.L.... Bates G.P.	2005	HTT
15	Ancient origin of the CAG expansion causing Huntington disease in a Spanish population. (15832309)	Garcia-Planells J.... Espinos C.	2005	HTT
16	Age-dependent changes in the calcium sensitivity of striatal mitochondria in mouse models of Huntington's Disease. (15935052)	Brustovetsky N.... Dubinsky J.M.	2005	HTT
17	Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice. (16019264)	Rodriguez-Lebron E.... Mandel R.J.	2005	HTT
18	Treatment of Huntington's disease with galantamine. (15101572)	Petrikis P.... Karavatos A.	2004	ACHE
19	Cognitive changes in patients with Huntington's disease (HD) and asymptomatic carriers of the HD mutation--a longitudinal follow-up study. (15316797)	Lemiere J.... Dom R.	2004	HTT
20	Platelet monoamine oxidase activity in subjects tested for Huntington's disease gene mutation. (15057517)	Markianos M.... Vassilopoulos D.	2004	MAOB
21	Analysis of the IT15 gene in Huntington's disease families (15523851)		2004	HTT
22	Huntington's disease genetics. (15717026)	Myers R.H.	2004	HTT
23	Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease. (12888569)	Busch A.... Wanker E.E.	2003	HTT
24	Huntington's disease-like phenotype due to trinucleotide repeat expansions in the TBP and JPH3 genes. (12805114)	Stevanin G.... Durr A.	2003	TBP, PRNP, JPH3
25	Impaired degradation of PKCalpha by proteasome in a cellular model of Huntington's disease. (12960759)	Zemskov E.A.... Nukina N.	2003	PRKCA
26	Inducible PC12 cell model of Huntington's disease sho ws toxicity and decreased histone acetylation. (12657886)	Igarashi S.... Ross C.A.	2003	HTT
27	Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease. (12009780)	PetersAcn A.... Aronin N.	2002	HTT
28	CAG/CTG repeat expansions at the Huntington's disease-like 2 locus are rare in Huntington's disease patients. (11914418)	Stevanin G.... Brice A.	2002	JPH3, HTT
29	Wild-type huntingtin up-regulates BDNF transcription in Huntington's disease. (11697536)	Reilly C.E.	2001	BDNF
30	The 'flap' endonuclease gene FEN1 is excluded as a candidate gene implicated in the CAG repeat expansion underlying Huntington disease. (11260214)	Otto C.J.... Andrew S.E.	2001	FEN1
31	The channel hypothesis of Huntington's disease. (11719262)	Kagan B.L.... Azimova R.	2001	HTT
32	Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease. (10717003)	Wyttenbach A.... Rubinsztein D.C.	2000	AR, ATXN3, ATXN1
33	Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. (10958656)	Passani L.A.... MacDonald M.E.	2000	SETD2, HTT, PRPF40B
34	Huntington disease: new insights on the role of huntingtin cleavage. (11128600)	Wellington C.L.... Hayden M.R.	2000	CASP6, HTT
35	Benzodiazepine receptor binding in Huntington's disease: [11C]flumazenil uptake measured using positron emission tomography. (10805336)	KA1nig G.... GA1nther I.	2000	TSPO
36	The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease. (10828533)	Glass M.... Faull R.L.	2000	CNR1
37	The status of SCA1, MJD/SCA3, FRDA, DRPLA and MD triplet containing genes in patients with Huntington disease and healthy controls. (11342385)	Keckarevic D.... Romac S.	2000	CASP3
38	The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease. (10486177)	Alexi T.... Gluckman P.D.	1999	GAD1, CHAT, CALB2
39	Are there multiple pathways in the pathogenesis of Huntington's disease? (10434298)	Aronin N.... DiFiglia M.	1999	RPS27A, HTT
40	Recent advances on the pathogenesis of Huntington's disease. (10222105)	Petersen A.... Brundin P.	1999	RPS27A, HIP1, HTT
41	Significantly lower incidence of cancer among patients with Huntington disease: An apoptotic effect of an expanded polyglutamine tract? (10506723)	SA... Olsen J.H.	1999	HTT
42	Replicating Huntington's disease phenotype in experim ental animals. (10515664)	Brouillet E.... Hantraye P.	1999	HTT
43	HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice. (9599014)	Bertaux F.... Wanker E.	1998	HTT, HAP1
44	Huntingtin localization in brains of normal and Huntington's disease patients. (9382472)	Sapp E.... DiFiglia M.	1997	HTT
45	Huntington's disease gene: regional and cellular expression in brain of normal and affected individuals. (7847863)	Landwehrmeyer G.B.... Bonilla E.	1995	HTT
46	A Sau3A polymorphism in the 5' end of the IT15 gene that nonrandomly segregates with the Huntington disease trinucleotide expansion. (7909529)	Carlock L.... Vo T.	1994	HTT
47	Glucose transporter isoform expression in Huntington's disease brain. (7931291)	Gamberino W.C.... Brennan W.A.	1994	SLC2A3
48	Trinucleotide repeat elongation in the huntingtin gen e in Huntington's disease patients from 85 French families. The French HD Resea rch Group. (7888133)	Lucotte G.... Turpin J.C.	1994	HTT
49	Huntington's disease in French families: CAG repeat expansion and linkage disequilibrium analysis. (8087617)	DodAc C.... Feingold J.	1993	HTT
50	Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus. (1532789)	Eubanks J.H.... Evans G.A.	1992	DRD5

Genes related to huntington's disease according to GeneCards:

(show top 50)    (show all 645)

id	Symbol	Description	Score	GeneCards Section Context
1	HTT	huntingtin	11.1	Publications, Summaries, Aliases & Descriptions, Pathways & Interactions (show all 5 sections) Orthologs
2	ZNF395	zinc finger protein 395	11.1	Publications, Aliases & Descriptions
3	HIP1	huntingtin interacting protein 1	11.1	Summaries, Publications, Pathways & Interactions
4	JPH3	junctophilin 3	11.1	Publications, UniProt Related, Summaries
5	PRNP	prion protein	11.1	Publications, Summaries
6	SLC2A4RG	SLC2A4 regulator	11.1	Publications, Aliases & Descriptions
7	HAP1	huntingtin-associated protein 1	11.1	Publications, Pathways & Interactions, Summaries
8	CALB1	calbindin 1, 28kDa	11.1	Publications, Summaries
9	BDNF	brain-derived neurotrophic factor	11.1	Publications, Pathways & Interactions, Summaries
10	UBE2K	ubiquitin-conjugating enzyme E2K	11.1	Publications, Summaries
11	CASP8	caspase 8, apoptosis-related cysteine peptidase	11.1	Publications, Pathways & Interactions, Summaries
12	SETD2	SET domain containing 2	11.1	Publications, Summaries
13	KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	11.0	Orthologs, Summaries
14	SETDB1	SET domain, bifurcated 1	11.0	Publications, Summaries
15	CASP1	caspase 1, apoptosis-related cysteine peptidase	11.0	Publications, Summaries
16	CASP2	caspase 2, apoptosis-related cysteine peptidase	11.0	Publications, Summaries
17	CXorf27	chromosome X open reading frame 27	11.0	Summaries
18	PFN1	profilin 1	11.0	Summaries
19	QPRT	quinolinate phosphoribosyltransferase	11.0	Summaries
20	DNAJC5	DnaJ (Hsp40) homolog, subfamily C, member 5	11.0	Summaries
21	KALRN	kalirin, RhoGEF kinase	11.0	Summaries
22	HLN2	Huntington-like neurodegenerative disorder 2	11.0
23	ATN1	atrophin 1	11.0	Publications
24	TBP	TATA box binding protein	11.0	Publications, Pathways & Interactions
25	AADAT	aminoadipate aminotransferase	11.0	Publications
26	CNTF	ciliary neurotrophic factor	11.0	Publications
27	TPPP3	tubulin polymerization-promoting protein family member 3	11.0	Publications
28	ADORA2A	adenosine A2a receptor	11.0	Publications
29	CHAT	choline O-acetyltransferase	11.0	Publications
30	CHERP	calcium homeostasis endoplasmic reticulum protein	11.0	Publications
31	NRTN	neurturin	11.0	Publications
32	TCERG1	transcription elongation regulator 1	11.0	Publications, Functions
33	BLVRB	biliverdin reductase B (flavin reductase (NADPH))	11.0	Publications
34	CNR1	cannabinoid receptor 1 (brain)	11.0	Publications
35	DFFB	DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)	11.0	Publications
36	XK	X-linked Kx blood group (McLeod syndrome)	11.0
37	CALB2	calbindin 2	11.0	Publications
38	GRK6	G protein-coupled receptor kinase 6	11.0
39	HCRT	hypocretin (orexin) neuropeptide precursor	11.0	Publications
40	IDUA	iduronidase, alpha-L-	11.0	Publications
41	IFT57	intraflagellar transport 57 homolog (Chlamydomonas)	11.0	Pathways & Interactions, Orthologs
42	PDE6B	phosphodiesterase 6B, cGMP-specific, rod, beta	11.0	Publications
43	TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications, Pathways & Interactions
44	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	11.0	Publications
45	ADD1	adducin 1 (alpha)	11.0	Publications
46	ATXN3	ataxin 3	11.0	Publications
47	CASP6	caspase 6, apoptosis-related cysteine peptidase	11.0	Publications
48	PRPF40A	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	11.0	Publications
49	DRD1	dopamine receptor D1	11.0	Publications
50	DRD2	dopamine receptor D2	11.0	Publications

Pathways related to huntington's disease according to GeneDecks:

(show top 50)    (show all 510)

id	Pathway	Score	Top Affiliating Genes
1	Endocrine and other factor-regulated calcium reabsorption20	12.3	CLTC, CLTB, CLTCL1, CLTA, AP2A1, AP2A2
2	Transcription Ligand-Dependent Transcription of Retinoid-Target genes10	11.3	NCOR1, NCOR2, SAP30, MED31, TBP, CREBBP
3	Long-term potentiation20	11.1	ITPR1, ITPR2, ITPR3, GRIA2, GRIN1, GRIN2A
4	Glutamic acid signaling10	11.1	GRIA2, GRIA4, GRIK1, GRIK2, GRIN1, GRIN2A
5	Prostate cancer20	10.1	PIK3R3, PIK3R2, PIK3R1, AR, GSK3B, FGFR2
6	ERK5 Signaling36	10.0	BDNF, FGF1, FGF12, FGFR3, IL2RA, GNA11
7	Colorectal Cancer Metastasis36	9.9	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BAX, GSK3B
8	UVA-Induced MAPK Signaling36	9.8	PIK3R3, PIK3R2, PIK3R4, PIK3R1, CASP3, CASP8
9	Presenilin-Mediated Signaling36	9.7	BTRC, UBB, UBD, UBC, AXIN1, GSK3B
10	Development_Endothelin-1/EDNRA signaling41	9.4	CDC42, ITPR1, ITPR2, ITPR3, GRB2, GNA11
11	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation10	9.4	CDC42, ITPR1, ITPR2, ITPR3, GNB1, GNB2
12	Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation41	9.4	CDC42, ITPR1, ITPR2, ITPR3, GNB1, GNB2
13	DNA Repair Mechanisms36	9.4	BARD1, FEN1, IGF1, TP53, PSMA1, PSMA2
14	Cholinergic synapse20	9.3	PIK3R3, PIK3R2, PIK3R1, CHAT, ITPR1, ITPR2
15	TRKA Signaling36	9.3	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BAX, CDC42
16	G-protein signaling_G-Protein alpha-i signaling cascades41	9.1	GRB2, GNAI1, GNAI2, GNAI3, GNAO1, GNAZ
17	BAD Phosphorylation36	9.1	PIK3R3, GRB2, APAF1, IGF1R, IGF1, GNA11
18	SOCS Pathway36	9.0	BAX, FGF1, FGF12, IL23A, PSMA1, PSMA2
19	Development_Alpha-2 adrenergic receptor activation of ERK41	9.0	PIK3R3, ITPR1, ITPR2, ITPR3, GRB2, GNAI1
20	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins10	8.9	CDC42, MAP2K6, GNA11, GNA12, GNA13, GNAI1
21	Ca, cAMP and Lipid Signaling3	8.7	ITPR1, GRIA2, GRIN2A, APOA4, GNA11, GNAI1
22	G-protein signaling G-Protein beta/gamma signaling cascades10	8.7	GRB2, GNA15, GNB1, GNB2, GNB3, GNB4
23	NF-KappaB Activation by EBV36	8.6	PIK3R3, PIK3R2, PIK3R4, PIK3R1, MAP2K6, MAP2K4
24	Development Beta-adrenergic receptors regulation of ERK10	8.6	CD44, ITPR1, ITPR2, ITPR3, GRB2, GNAI1
25	Development EDNRB signaling10	8.4	ITPR1, ITPR2, ITPR3, GRB2, GNA11, GNAI1
26	Development_Angiotensin activation of ERK41	8.4	ITPR1, ITPR2, ITPR3, GRB2, GNA11, GNAI1
27	Neuropathic Pain-Signaling in Dorsal Horn Neurons36	8.3	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BDNF, GRIA2
28	Development_G-Proteins mediated regulation MARK-ERK signaling41	8.3	ITPR1, ITPR2, ITPR3, GRB2, GNA11, GNA12
29	Prolactin Signaling36	8.2	PIK3R3, PIK3R2, PIK3R4, MAP2K6, MAP2K4, CREBBP
30	G-protein signaling_G-Protein alpha-q signaling cascades41	8.1	ITPR1, ITPR2, ITPR3, GRB2, GNA11, GNAQ
31	Translation_Translation regulation by Alpha-1 adrenergic receptors41	8.0	PIK3R1, ITPR1, ITPR2, ITPR3, GNA11, GNAO1
32	Development Angiotensin signaling via PYK210	7.9	PIK3R3, PIK3R2, PIK3R1, ITPR1, ITPR2, ITPR3
33	Rho Family GTPases36	7.9	PIK3R3, PIK3R2, PIK3R4, PIK3R1, VIM, BDNF
34	VEGF and S-1P Signaling36	7.8	MAP2K6, MAP2K4, GNA11, GNA12, GNA13, GNA14
35	Development_Activation of ERK by Alpha-1 adrenergic receptors41	7.7	PIK3R1, ITPR1, ITPR2, ITPR3, GNA11, GNA14
36	Dopamine-DARPP32 Feedback onto cAMP Pathway36	7.7	PAWR, KCNAB1, KCNAB2, KCNC3, CDK5, ITPR1
37	Relaxin Pathway36	7.6	PIK3R3, PIK3R2, PIK3R4, PIK3R1, PDE1B, GNA11
38	Signal transduction Activation of PKC via G-Protein coupled receptor10	7.6	ITPR1, ITPR2, ITPR3, GSK3B, GNA11, GNAQ
39	FGF Pathway36	7.5	PIK3R3, PIK3R2, PIK3R4, PIK3R1, CDC42, ITPR1
40	IGF1R Signaling36	7.4	PIK3R3, PIK3R2, PIK3R4, PIK3R1, ITPR1, ITPR2
41	Development_VEGF signaling via VEGFR2 - generic cascades41	7.0	PIK3R3, PIK3R2, PIK3R1, ITPR1, ITPR2, ITPR3
42	Activation of cAMP-Dependent PKA36	7.0	PDE1B, BDNF, ITPR1, ITPR2, ITPR3, GSK3B
43	Phospholipase-C Pathway36	6.8	BDNF, CD79A, ITPR1, ITPR2, ITPR3, MGC16025
44	Activation of PKA through GPCR36	6.7	PDE1B, BDNF, ITPR1, ITPR2, ITPR3, GSK3B
45	CREB Pathway36	6.3	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BDNF, ITPR1
46	MAPK Signaling36	6.1	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BDNF, ATF6
47	fMLP Pathway36	5.5	PIK3R3, PIK3R2, PIK3R4, PIK3R1, CDC42, ITPR1
48	PTEN Pathway36	5.2	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BDNF, CDC42
49	WNT Signaling36	4.4	REST, BTRC, VIM, UBB, UBD, UBC
50	Huntingtons Disease Pathway36	2.4	PIK3R3, PIK3R2, PIK3R4, PIK3R1, NCOR1, NCOR2

Compounds related to huntington's disease according to GeneDecks:

(show top 50)    (show all 430)

id	Compound	Score	Top Affiliating Genes
1	nmda32 42	20.9	REST, CNR1, VIM, BLVRB, BDNF, SDHB
2	calcium32 9 18 9	22.6	PDC, REST, SGK1, CNR1, CNTF, PCP4
3	atp32	19.6	PIK3R1, SETD2, VIM, VDAC1, VDAC2, RAB6A
4	iron32 18	20.3	SETD2, SERPINA3, VIM, VDAC1, BLVRB, BDNF
5	dopamine32 9 18 9	22.3	CNTF, SERPINA3, BLVRB, BDNF, SDHB, CHAT
6	retinoic acid32 42 18	20.8	NCOR1, NCOR2, CNTF, SETD2, SERPINA3, VIM
7	cysteine32	18.7	SERPINA3, NAT2, VDAC1, RAB6A, RAN, RAB5A
8	lipid32	17.3	PIK3R1, NCOR2, PDC, SGK1, CNR1, CNTF
9	gaba32 42	18.0	CNR1, CNTF, VIM, VDAC1, BLVRB, BDNF
10	lactate32	15.8	SETD2, VIM, VDAC1, BDNF, SDHB, CKB
11	kainate32	15.7	REST, CNR1, BLVRB, BDNF, CHAT, CDKN3
12	adenylate32	15.6	PDC, SGK1, CNR1, CNTF, VIM, VDAC1
13	choline32 9 18 9	18.4	CNTF, VIM, BLVRB, BDNF, CHAT, MTHFR
14	estrogen32	15.1	PIK3R1, NCOR1, NCOR2, SETD2, SERPINA3, NAT2
15	superoxide32 18	16.0	PIK3R1, CNTF, SETD2, SERPINA3, RAN, BLVRB
16	creatinine32	14.9	SGK1, VPS13A, SERPINA3, VDAC1, BDNF, SDHB
17	cocaine32 9 9	16.9	CNR1, CNTF, VIM, BDNF, LEP, CHAT
18	vegf32	14.8	PIK3R1, CNTF, RCAN1, SETD2, PARP1, BDNF
19	actinomycin d32	14.4	SGK1, CNTF, SETD2, VIM, PARP1, BDNF
20	glucose32	14.3	CNTF, SETD2, BLVRB, PAWR, CKB, MT-CO1
21	h2o232	14.2	PIK3R1, SGK1, CNTF, RCAN1, VDAC1, RAN
22	paraffin32	13.9	SERPINA3, VIM, BLVRB, LEP, CHAT, BAX
23	6-hydroxydopamine32	13.9	BDNF, CHAT, CDK5, GSR, FGF1, APP
24	butyrate32	13.9	SETD2, VIM, LEP, CHAT, BAX, CDKN3
25	histamine32 18	14.9	CNR1, CNTF, VIM, BDNF, CD79A, GRK6
26	levodopa32 9 9	15.9	CNR1, BDNF, CDK5, CDKN3, MAOA, MAOB
27	mptp32	13.8	VDAC1, BDNF, BAX, GRIN1, APAF1, MAOA
28	progesterone32 42 9 18 9	17.7	PIK3R1, NCOR1, NCOR2, CNTF, SETD2, SERPINA3
29	formaldehyde32 18	14.6	VIM, BLVRB, CHAT, CD79A, CDKN3, CD44
30	cholesterol32 9 18 9	16.3	PIK3R1, SERPINA3, NAT2, RAB6A, BECN1, BDNF
31	4-hydroxynonenal32 18	14.2	PARP1, CHAT, BAX, GSR, APOE, APP
32	camptothecin32 42 9 9	16.2	SETD2, PARP1, BDNF, BAX, XRCC6, CDKN3
33	threonine32	13.0	RCAN1, MT-CYB, CDK5, CDC42, CDK5R1, FGFR2
34	ethanol32 34 9 18 9	16.9	BLVRB, BDNF, SDHB, CHAT, MTR, ITPR1
35	tetrodotoxin32	12.8	CNR1, BDNF, APOE, ENO2, CCK, GNRH1
36	gtp32	12.7	PIK3R1, PDC, VDAC1, RAB6A, RAB3A, RAN
37	guanine32 9 18 9	15.6	CNR1, SETD2, RAB5A, MTHFR, SAFB, CDC42
38	glyceraldehyde 3-phosphate32	12.6	SETD2, VDAC1, SDHA, SDHB, CKB, UCHL1
39	mg 13232 42	13.5	NCOR2, PARP1, BAX, AR, FASLG, FAS
40	opiate32	12.3	APP, FAS, CCK, GNAI1, GNRH1, GH1
41	phosphatidylserine32 9 9	14.2	VIM, PARP1, CD79A, APAF1, MAPT, F2
42	genistein32 9 18 9	15.2	PIK3R1, CNTF, SETD2, VIM, PARP1, BAX
43	tamoxifen32 34 9 9	15.2	NCOR1, NCOR2, VIM, BDNF, CKB, LEP
44	c2ceramide32	12.0	BECN1, PARP1, BAX, HSPB1, HSPA4, CASP3
45	inositol32	11.5	BDNF, CD79A, ITPR3, GSK3B, FGF1, IMPA1
46	n acetylcysteine32	11.2	SETD2, BDNF, CD79A, CDK5, AR, FGFR2
47	wortmannin32 42	11.8	PIK3R4, PIK3R1, SGK1, CNTF, SETD2, VIM
48	gf 109203x32 42	10.9	CDKN3, GRB2, APP, GNRH1, HSPB1, HSPA4
49	N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE9 9	10.8	PSMA1, PSMA2, PSMA4, PSMA6, PSMA7, PSMB2
50	grk2i42	9.1	GNB1, GNB2, GNB3, GNB4, GNB5, GNG10

Cellular components related to huntington's disease according to GeneDecks:

(show all 41)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	24.0	ZNF395, ZNF33B, ZNF141, PIAS4, LRIF1, NCOR1
2	cytoplasm	GO:005737	22.8	ZNF395, PIAS4, PDC, PDE1B, REST, RCAN1
3	mitochondrial inner membrane	GO:005743	20.4	VDAC1, VDAC2, UQCR10, UQCR11, UQCRB, UQCRC1
4	mitochondrion	GO:005739	18.6	SGK1, VDAC1, VDAC2, VDAC3, CLTC, UQCRC1
5	cytosol	GO:005829	17.5	PIK3R3, PIK3R2, PIK3R4, PIK3R1, PDC, PDE10A
6	nucleolus	GO:005730	15.6	PIAS4, NCOR2, PDE1B, REST, RBM48, SETDB1
7	mitochondrial respiratory chain complex I	GO:005747	15.5	NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2
8	plasma membrane	GO:005886	13.8	PIK3R1, SGK1, CNR1, SETDB1, VIM, VDAC1
9	nucleoplasm	GO:005654	13.6	NCOR1, NCOR2, RCOR1, RAN, PARP1, UBB
10	axon	GO:030424	13.6	CNTF, VIM, CHAT, UCHL1, CDK5, CDK5R1
11	neuronal cell body	GO:043025	13.3	PDE1B, CNTF, CHAT, UCHL1, ATP2B2, CDK5
12	mitochondrial matrix	GO:005759	12.6	ATP5D, ATP5B, ATP5E, ATP5C1, ATP5A1, ATP5F1
13	cell junction	GO:030054	12.5	ATN1, CDK5, ARFGEF2, GRIA2, GRIA4, GRIK1
14	microtubule	GO:005874	12.5	FEZ1, MAPT, MAP1LC3A, MAP2, CCT3, TUBA1B
15	postsynaptic density	GO:014069	12.3	CDK5, CDK5R1, ITPR1, GRIA2, GRIA4, GRIN1
16	mitochondrial proton-transporting ATP synthase complex	GO:005753	12.3	ATP5D, ATP5B, ATP5O, ATP5J, ATP5E, ATP5G1
17	mitochondrial membrane	GO:031966	12.2	ATP5B, HTRA2, CASP7, NDUFA1, NDUFA13, NDUFA2
18	dendrite	GO:030425	12.2	ATP2B2, CDK5, CDK5R1, AR, GRIN1, APOE
19	perinuclear region of cytoplasm	GO:048471	12.1	PACSIN1, CHERP, UBQLN1, AXIN1, ATN1, KAT5
20	DNA-directed RNA polymerase II, core complex	GO:005665	12.0	PPARGC1A, POLR2A, POLR2B, POLR2E, POLR2F, POLR2I
21	mitochondrial respiratory chain	GO:005746	11.9	UQCRB, UQCRC1, UQCRH, COX7A2, COX7B, COX7B2
22	synapse	GO:045202	11.8	PACSIN1, GRIN1, APP, DLG4, SUMO1, SNAP25
23	presynaptic membrane	GO:042734	11.7	GRIA2, GRIK2, GRIN2A, GRIN2B, GRM1, GRM2
24	growth cone	GO:030426	11.6	CDK5, CDK5R1, GSK3B, GRIA2, MAPT, NTRK2
25	terminal button	GO:043195	11.6	GRIA2, GRIA4, GRIK2, GRIN1, GRIN2A, GRIN2B
26	endocytic vesicle membrane	GO:030666	11.5	UBB, UBC, GRIA2, GRIA4, AP2A1, AP2A2
27	respiratory chain	GO:070469	11.4	UQCR10, UQCR11, UQCRQ, CYC1, CYCS
28	mitochondrial outer membrane	GO:005741	11.4	VDAC1, VDAC2, VDAC3, BBC3, BAX, MAOA
29	histone deacetylase complex	GO:000118	11.4	NCOR1, SAP30, TAL1, HDAC1, HDAC10, HDAC11
30	axonemal dynein complex	GO:005858	11.3	DNAH3, DNALI1, DNAH1, DNAH2, DNAI2, DNAL4
31	clathrin coat of coated pit	GO:030132	11.3	CLTC, CLTB, CLTCL1, CLTA, AP2M1
32	clathrin coat of trans-Golgi network vesicle	GO:030130	11.2	CLTC, CLTB, CLTCL1, CLTA, AP2A1
33	nuclear matrix	GO:016363	11.1	PIAS4, LRIF1, ATXN3, ATXN1, ATN1, ATXN7
34	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane	GO:061202	11.0	RAB3A, HSPA8, DNAJC5, GAD1, GAD2
35	N-methyl-D-aspartate selective glutamate receptor complex	GO:017146	10.9	GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D
36	mitochondrial respiratory chain complex II	GO:005749	10.9	SDHA, SDHB, SDHC, SDHD
37	transcriptional repressor complex	GO:017053	10.7	NCOR1, NCOR2, REST, RCOR1, ZBTB16, SP3
38	proteasome core complex, alpha-subunit complex	GO:019773	10.4	PSMA1, PSMA2, PSMA4, PSMA6, PSMA7, PSMA3
39	proteasome core complex	GO:005839	10.3	PSMA6, PSMB2, PSMB4, PSMB5, PSMB7, PSMB9
40	heterotrimeric G-protein complex	GO:005834	10.0	GNA15, GNAT2, GNB1, GNB5, GNG10, GNG11
41	proteasome complex	GO:000502	9.4	UBQLN1, HSPB1, DNAJB2, PSMA1, PSMA2, PSMA4

Biological processes related to huntington's disease according to GeneDecks:

(show top 50)    (show all 119)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	20.0	PIK3R3, PIK3R2, PIK3R4, PIK3R1, NCOR1, NCOR2
2	respiratory electron transport chain	GO:022904	19.6	UQCR10, UQCR11, UQCRB, UQCRC1, UQCRC2, UQCRFS1
3	mitochondrial electron transport, NADH to ubiquinone	GO:006120	15.0	NDUFA1, NDUFA10, NDUFA2, NDUFA3, NDUFA4, NDUFA5
4	synaptic transmission	GO:007268	14.3	RAB3A, KCNAB1, KCNAB2, KCNC3, CHAT, ATXN3
5	transcription initiation from RNA polymerase II promoter	GO:006367	13.5	NCOR1, NCOR2, PARP1, UBB, UBC, YAP1
6	apoptotic process	GO:006915	13.4	PDE1B, SGK1, VIM, VDAC1, PAWR, ZBTB16
7	response to drug	GO:042493	13.3	BDNF, UQCRFS1, CHAT, ATG5, FXN, GSK3B
8	positive regulation of apoptotic process	GO:043065	12.7	PIAS4, REST, CNR1, PAWR, ZBTB16, UBD
9	negative regulation of neuron apoptotic process	GO:043524	12.6	CNTF, BDNF, BAX, GRIK2, GRIN1, HTT
10	transcription elongation from RNA polymerase II promoter	GO:006368	12.2	IKBKAP, TBP, TAF4B, TAF1, TAF4, POLR2A
11	locomotory behavior	GO:007626	11.9	PDE1B, RASD2, ATP2B2, GRM1, APP, HTT
12	mitochondrial ATP synthesis coupled proton transport	GO:042776	11.8	ATP5D, ATP5B, ATP5O, ATP5J, ATP5E, ATP5G1
13	gene expression	GO:010467	11.7	NCOR1, NCOR2, RAN, PARP1, UBB, UBC
14	neuron apoptotic process	GO:051402	11.6	BAX, ATN1, CDK5, GRIK2, APP, FAS
15	response to amphetamine	GO:001975	11.6	PDE1B, GRIN1, GRIN2A, GRIN2B, GNAL, DRD1
16	anti-apoptosis	GO:006916	11.5	BECN1, BDNF, UBB, UBC, GSK3B, APOE
17	regulation of excitatory postsynaptic membrane potential	GO:060079	11.4	CDK5, GRIK2, GRIN1, GRIN2A, GRIN2B, GRIN2C
18	viral reproduction	GO:016032	11.3	BTRC, RAN, UBB, UBC, XRCC6, AP2A1
19	virus-host interaction	GO:019048	11.2	PIK3R1, RCOR1, BTRC, VIM, VDAC1, RAN
20	negative regulation of epidermal growth factor receptor signaling pathway	GO:042059	11.2	CLTC, CLTA, UBB, UBC, CDC42, GRB2
21	nerve growth factor receptor signaling pathway	GO:048011	11.0	PIK3R2, PIK3R1, PDE1B, CLTC, CLTA, UBB
22	signal transduction	GO:007165	10.5	SH3BP2, SH3GL3, PDE10A, PDE1B, CNTF, RCAN1
23	protein phosphorylation	GO:006468	10.5	PIK3R4, SGK1, PACSIN1, KALRN, GSK3B, APP
24	cellular nitrogen compound metabolic process	GO:034641	10.4	CKB, BBOX1, MTR, CCBL2, CCBL1, ALDH7A1
25	energy reserve metabolic process	GO:006112	10.2	LEP, ITPR1, ITPR2, ITPR3, GNB1, GNB2
26	regulation of apoptotic process	GO:042981	10.0	SGK1, UBB, UBC, CDK5, FGFR3, APAF1
27	cellular response to glucagon stimulus	GO:071377	9.9	GNB1, GNB2, GNB3, GNB4, GNG10, GNG11
28	activation of phospholipase C activity	GO:007202	9.7	PDE1B, ITPR1, ITPR2, ITPR3, GNA15, GNAQ
29	GTP catabolic process	GO:006184	9.5	RAB6A, RAB3A, CDC42, GNA11, GNA12, GNA13
30	epidermal growth factor receptor signaling pathway	GO:007173	9.5	PIK3R1, PDE1B, CLTC, CLTA, UBB, UBC
31	fibroblast growth factor receptor signaling pathway	GO:008543	9.3	PIK3R1, PDE1B, UBB, UBC, ITPR1, ITPR2
32	mitotic cell cycle	GO:000278	9.2	PCM1, BTRC, UBB, UBC, FEN1, TUBB
33	S phase of mitotic cell cycle	GO:000084	9.2	UBB, UBC, FEN1, RPS27A, PSMA1, PSMA2
34	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:006977	9.2	UBB, UBC, CASP2, TP53, RPS27A, PSMA1
35	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	9.1	UBB, UBC, HLA-G, RPS27A, PSMA1, PSMA2
36	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	9.1	UBB, UBC, HLA-G, RPS27A, PSMA1, PSMA2
37	G1/S transition of mitotic cell cycle	GO:000082	9.1	UBB, UBC, CDKN3, RPS27A, PSMA1, PSMA2
38	cell cycle checkpoint	GO:000075	9.1	UBB, UBC, TP53, RPS27A, PSMA1, PSMA2
39	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	9.0	UBB, UBC, HLA-G, RPS27A, PSMA1, PSMA2
40	regulation of cellular amino acid metabolic process	GO:006521	9.0	PSMA1, PSMA2, PSMA4, PSMA6, PSMA7, PSMB2
41	RNA metabolic process	GO:016070	9.0	UBB, UBC, HSPB1, HSPA8, AKT1, RPS27A
42	mRNA metabolic process	GO:016071	9.0	UBB, UBC, HSPB1, HSPA8, AKT1, RPS27A
43	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:051436	8.9	UBB, UBC, RPS27A, PSMA1, PSMA2, PSMA4
44	M/G1 transition of mitotic cell cycle	GO:000216	8.9	UBB, RPS27A, PSMA1, PSMA2, PSMA4, PSMA6
45	protein polyubiquitination	GO:000209	8.9	BTRC, UBB, UBC, AXIN1, RPS27A, PSMA1
46	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:031145	8.8	BTRC, UBB, UBC, RPS27A, PSMA1, PSMA2
47	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:051437	8.7	BTRC, UBB, UBC, RPS27A, PSMA1, PSMA2
48	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:051439	8.7	BTRC, UBB, UBC, RPS27A, PSMA1, PSMA2
49	blood coagulation	GO:007596	7.8	PIK3R3, PIK3R2, PIK3R1, PDE10A, PDE1B, RCOR1
50	platelet activation	GO:030168	6.8	PIK3R3, PIK3R2, PIK3R1, ITPR1, ITPR2, ITPR3

Molecular functions related to huntington's disease according to GeneDecks:

(show all 40)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	27.7	PIK3R2, PIK3R4, PIK3R1, PIAS4, LRIF1, SH3BP2
2	NADH dehydrogenase (ubiquinone) activity	GO:008137	15.2	NDUFA1, NDUFA10, NDUFA12, NDUFA13, NDUFA2, NDUFA3
3	protein homodimerization activity	GO:042803	13.9	ZBTB16, BARD1, BAX, QPRT, AXIN1, ATG7
4	cytochrome-c oxidase activity	GO:004129	13.0	COX6A1, COX4I2, COX7A2, COX7B, COX6A2, COX6B1
5	electron carrier activity	GO:009055	12.9	UQCR11, SDHB, SDHC, SDHD, GSR, MAOB
6	transcription factor binding	GO:008134	12.4	REST, BRD7, PARP1, AR, TP53, TP73
7	DNA-directed RNA polymerase activity	GO:003899	12.3	POLR2A, POLR2B, POLR2E, POLR2F, POLR2I, POLR2J
8	metal ion binding	GO:046872	12.3	PDE10A, PDE1B, UQCRC1, UQCRC2, UQCRFS1, SDHB
9	chromatin binding	GO:003682	12.1	REST, RAN, YAP1, SAFB, AR, TP53
10	transcription regulatory region DNA binding	GO:044212	12.1	NCOR1, REST, RCOR1, BRD7, YAP1, XRCC6
11	protein complex binding	GO:032403	12.0	REST, UQCRC1, UQCRC2, UQCRFS1, UQCRH, ATP5D
12	transmembrane transporter activity	GO:022857	11.9	ATP5D, ATP5B, ATP5O, ATP5J, ATP5E, ATP5H
13	drug binding	GO:008144	11.8	CNR1, ATP5O, GRIN2B, DRD1, DRD2, DRD5
14	ubiquinol-cytochrome-c reductase activity	GO:008121	11.7	UQCR10, UQCR11, UQCRB, UQCRC1, UQCRFS1, UQCRH
15	NADH dehydrogenase activity	GO:003954	11.6	NDUFA12, NDUFA13, NDUFA9, NDUFS2, NDUFS3, NDUFS7
16	protein kinase activity	GO:004672	11.6	PIK3R4, PACSIN1, CDK5, CDK5R1, MAP3K10, MAP2K4
17	identical protein binding	GO:042802	11.6	SH3GL3, PCM1, VIM, ZBTB16, BAX, AXIN1
18	extracellular-glutamate-gated ion channel activity	GO:005234	11.4	GRIA2, GRIA4, GRIK1, GRIK2, GRIN1, GRIN2A
19	p53 binding	GO:002039	11.4	BRD7, AXIN1, MSX1, CDK5, GSK3B, HTT
20	enzyme binding	GO:019899	11.4	PAWR, AXIN1, ATG3, FXN, AR, MAPT
21	ATPase activity	GO:016887	11.3	ATP5D, ATP5B, ATP5O, ATP5J, ATP5E, ATP5H
22	protein kinase binding	GO:019901	11.3	VIM, AXIN1, CDC42, CDK5R1, GSK3B, GRB2
23	ionotropic glutamate receptor binding	GO:035255	11.2	GSK3B, GRIN2B, DRD2, DLG4, CTNNB1, ADRB2
24	hydrogen ion transporting ATP synthase activity, rotational mechanism	GO:046933	11.1	ATP5D, ATP5B, ATP5O, ATP5E, ATP5C1, ATP5A1
25	NAD-dependent histone deacetylase activity (H3-K14 specific)	GO:032041	11.1	HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC5
26	NAD-dependent histone deacetylase activity (H4-K16 specific)	GO:046970	11.1	HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC5
27	histone deacetylase activity	GO:004407	11.1	HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC5
28	NAD-dependent histone deacetylase activity (H3-K9 specific)	GO:046969	11.1	HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC5
29	histone deacetylase binding	GO:042826	11.0	NCOR1, NCOR2, SP1, KPNA2, TAL1, SIRT2
30	N-methyl-D-aspartate selective glutamate receptor activity	GO:004972	11.0	GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D
31	protein deacetylase activity	GO:033558	11.0	SIRT2, HDAC1, HDAC10, HDAC2, HDAC3, HDAC9
32	GTP binding	GO:005525	10.9	RAB6A, RAB3A, RAN, RAB5A, RASD2, CDC42
33	GTPase activity	GO:003924	10.9	RAB6A, RAB3A, RAN, RAB5A, RASD2, CDC42
34	ATP binding	GO:005524	10.5	PIK3R4, SGK1, CLK1, CKB, CHD3, UBE2K
35	threonine-type endopeptidase activity	GO:004298	10.0	PSMA1, PSMA2, PSMA4, PSMA6, PSMA7, PSMB2
36	phosphatidylinositol phospholipase C activity	GO:004435	9.8	PLCB2, PLCB4, PLCD1, PLCD3, PLCD4, PLCG1
37	signal transducer activity	GO:004871	9.6	CLTCL1, ZDHHC17, AXIN1, FAS, IKBKAP, GNA15
38	phospholipase C activity	GO:004629	9.5	PLCB2, PLCB4, PLCG1, PLCB3, PLCE1, PLCG2
39	protein kinase C activity	GO:004697	9.0	PRKCE, PRKCG, PRKCH, PRKCI, PRKCZ, PRKCQ
40	insulin receptor substrate binding	GO:043560	8.1	PIK3R1, GRB2, IGF1R, PTPN11, PRKCD, PRKCZ