HD
MCID: HNT001
MIFTS: 86

Huntington's Disease (HD) malady

Neuronal diseases category

Summaries for Huntington's Disease

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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NINDS:43 Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.

MalaCards: Huntington's Disease, also known as huntington disease, is related to huntington disease-like 2 and motor neuron disease, and has symptoms including cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy, eeg anomalies and movement disorder. An important gene associated with Huntington's Disease is HTT (huntingtin), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Apoptotic Pathways in Synovial Fibroblasts. The drugs baclofen and perphenazine and the compounds atp and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are nervous system and mortality/aging.

Disease Ontology:8 A neurodegenerative disease that has material basis in expansion of cag repeats resulting in neuron degeneration affecting muscle coordination, cognitive abilities.

Genetics Home Reference:21 Huntington disease is a progressive brain disorder that causes uncontrolled movements, emotional problems, and loss of thinking ability (cognition).

NIH Rare Diseases:42 Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain.  this results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. symptoms typically appear between the ages of 35 and 44 years. people with huntington disease most often live for 15 to 18 years after the condition appears. huntington disease caused by mutations in the htt gene and is inherited in an autosomal dominant manner. each child of a person with huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. there is also a less common, early-onset from that begins in childhood or adolescence, called juvenile huntington disease. last updated: 6/27/2011

MedlinePlus:33 Huntington's disease (hd) is an inherited disease that causes certain nerve cells in the brain to waste away. people are born with the defective gene, but symptoms usually don't appear until middle age. early symptoms of hd may include uncontrolled movements, clumsiness, and balance problems. later, hd can take away the ability to walk, talk, and swallow. some people stop recognizing family members. others are aware of their environment and are able to express emotions. if one of your parents has huntington's disease, you have a 50 percent chance of getting it. a blood test can tell you if have the hd gene and will develop the disease. genetic counseling can help you weigh the risks and benefits of taking the test. there is no cure. medicines can help manage some of the symptoms, but cannot slow down or stop the disease. nih: national institute of neurological disorders and stroke

Wikipedia:63 Huntington\'s disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and... more...

Description from OMIM:46 143100

GeneReviews summary for huntington

Aliases & Classifications for Huntington's Disease

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Sources:
8Disease Ontology, 63Wikipedia, 42NIH Rare Diseases, 21Genetics Home Reference, 43NINDS, 33MedlinePlus, 30LifeMap Discovery™, 9diseasecard, 19GeneReviews, 20GeneTests, 46OMIM, 44Novoseek, 48Orphanet, 60UMLS, 22GTR, 10DISEASES, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
huntington disease:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age
juvenile huntington disease:
Inheritance: Autosomal dominant; Prevalence: 1-9/1000000; Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

huntington's disease 8 63 42 21 43 33 30
huntington disease 9 19 42 20 21 46 44 48 60
huntington chorea 19 22 21 48
huntington's chorea 8 42 21
juvenile huntington disease 48 60
hd 8 42
huntington chronic progressive hereditary chorea 21
progressive chorea, chronic hereditary 63
huntington's disease pathway 8
juvenile huntington chorea 48
huntingtons disease 10
jhd 48


External Ids:

Disease Ontology8 DOID:12858
ICD9CM27 333.4
MeSH34 D006816
OMIM46 143100
NCIt39 C82342
SNOMED-CT56 58756001, 155006000
MESH via Orphanet35 D006816
ICD10 via Orphanet26 G10
SNOMED-CT via Orphanet57 58756001, 230299004
UMLS via Orphanet61 C0020179, C0751208
ICD1025 G10

Related Diseases for Huntington's Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Huntington's Disease family:

Huntington Disease-Like 2 Juvenile Huntington Disease
Huntington Disease-Like 1 Huntington Disease-Like Syndrome
Huntington Disease-Like 3

Diseases related to Huntington's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1huntington disease-like 230.8JPH3
2motor neuron disease30.1HTT, BDNF
3ischemia30.0BDNF, CASP1, CASP2, KMO, SETD2
4pancreatitis30.0CASP1
5dementia29.9BDNF, HTT, HAP1, PRNP
6dentatorubral-pallidoluysian atrophy29.9PRNP, JPH3, HTT
7prion disease29.9BDNF, HTT, PRNP
8breast cancer29.8CASP1, CASP8, CASP2, HTT, PFN1, SETD2
9brain disease10.5
10huntington disease-like 110.3
11huntington disease-like 310.3
12chromosomal disease10.2
13juvenile huntington disease10.2
14fragile x syndrome10.1
15schizophrenia10.1
16normal pressure hydrocephalus10.1
17hydrocephalus10.1
18attention deficit hyperactivity disorder10.0
19conduct disorder10.0
20neuronitis10.0
21infectious mononucleosis10.0
22hypertension10.0
23b cell deficiency10.0
24malaria10.0
25alzheimer's disease10.0BDNF, CASP1, CALB1, CASP2, HTT, PRNP
26parkinson's disease10.0BDNF, CASP8, CALB1, HTT, PRNP
27amyotrophic lateral sclerosis10.0BDNF, CASP1, HTT, PRNP
28astrocytoma10.0CASP8, CASP2, PRNP, SETD2
29epilepsy syndrome10.0BDNF, CALB1, CASP2, PRNP
30toxic encephalopathy10.0BDNF, HTT, PRNP
31memory impairment10.0PRNP, CALB1, BDNF
32temporal lobe epilepsy10.0BDNF, CALB1, PRNP
33multiple sclerosis10.0CASP8, CASP1, BDNF
34pancreatic cancer10.0BDNF, CASP1, CASP8, SETD2
35multiple system atrophy10.0PRNP, HTT
36colon cancer10.0CASP1, CASP8, SETD2
37ovarian cancer10.0SETD2, CASP2, CASP8, CASP1
38neuroblastoma10.0PRNP, BDNF
39encephalitis10.0CALB1
40machado-joseph disease9.9
41cerebritis9.9
42hereditary spastic paraplegia9.9
43leber hereditary optic neuropathy9.9
44lipoid proteinosis9.9
45chorea-acanthocytosis9.9
46breast disease9.9
47cerebellar disease9.9
48myotonic disease9.9
49myotonic dystrophy9.9
50paraplegia9.9

Graphical network of the top 20 diseases related to Huntington's Disease:



Diseases related to huntington's disease

Clinical Features for Huntington's Disease

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

143100

Clinical synopsis from OMIM:

143100

Symptoms:

48 (show all 8)
  • cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy
  • eeg anomalies
  • movement disorder
  • hypertonia/spasticity/rigidity/stiffness
  • psychic/psychomotor regression/dementia/intellectual decline
  • psychic/behavioural troubles
  • autosomal dominant inheritance
  • abnormal cry/voice/phonation disorder/nasal speech

Drugs & Therapeutics for Huntington's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Huntington's Disease

Drug clinical trials:

Search ClinicalTrials for Huntington's Disease

Search NIH Clinical Center for Huntington's Disease

Search CenterWatch for Huntington's Disease

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Huntington's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Huntington's Disease:
Embryonic stem cell-derived GABA progenitor cells for treatment of Huntington's disease
Embryonic/Adult Cultured Cells Related to Huntington's Disease:
Lateral Ganglionic Eminence progenitors, PMID: 22424902

Genetic Tests for Huntington's Disease

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Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Huntington's Disease:

id Genetic test Affiliating Genes
1 Huntington Disease20 HTT
2 Huntington's Chorea22

Anatomical Context for Huntington's Disease

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Huntington's Disease:

32
Brain, Testes, Cortex, Prefrontal cortex, Globus pallidus, Caudate nucleus, Heart, Breast, Skin, Thyroid, Pons, Pituitary, Cerebellum, Eye

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Huntington's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BrainStriatum  Affected by disease

Animal Models for Huntington's Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Huntington's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363112.9SETD2, BDNF, CASP1, CASP8, CALB1, CASP2
2MP:001076812.5BDNF, CASP1, CASP8, CASP2, HTT, HAP1
3MP:000538412.0BDNF, CASP1, CASP8, CASP2, UBE2K, HTT
4MP:000537612.0CASP1, CASP8, HTT, HAP1, PRNP, HIP1
5MP:000537811.9BDNF, CASP8, HTT, HAP1, JPH3, PRNP
6MP:000538911.7BDNF, CASP1, CASP2, HTT, JPH3, PRNP
7MP:000538611.5BDNF, CALB1, HTT, HAP1, JPH3, PRNP

Publications for Huntington's Disease

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Sources:
50PubMed
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Articles related to Huntington's Disease:

(show top 50)    (show all 1109)
idTitleAuthorsYear
1
Surface electromyograph activity of submental muscles during swallowing and expiratory muscle training tasks in Huntington's disease patients. (24182734)
2014
2
High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease. (23863947)
2013
3
Genome-scale study of Huntington's disease identifies potential drug targets. (23327572)
2013
4
Off label use of lithium in the treatment of Huntington's disease: A case series. (23439971)
2013
5
Golgi protein ACBD3 mediates neurotoxicity associated with Huntington's disease. (24012756)
2013
6
Motor, emotional and cognitive deficits in adult BACHD mice: a model for Huntington's disease. (23123142)
2013
7
Unified Huntington's disease rating scale for advanced patients: validation and follow-up study. (24166899)
2013
8
The differential diagnosis of Huntington's disease-like syndromes: 'red flags' for the clinician. (22993450)
2013
9
Huntington's disease in children. (23622414)
2013
10
Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease. (23275441)
2013
11
Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems. (22965876)
2012
12
Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington's disease. (22583646)
2012
13
Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells. (22613578)
2012
14
Implicit contextual learning in prodromal and early stage Huntington's disease patients. (22643097)
2012
15
Elevated brain iron is independent from atrophy in Huntington's Disease. (22480728)
2012
16
An unusually low prevalence of Huntington's disease in Iceland. (22722209)
2012
17
ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease. (22240898)
2012
18
Cortical myoclonus in childhood and juvenile onset Huntington's disease. (22494662)
2012
19
Impaired ideomotor limb apraxia in cortical and subcortical dementia: a comparison of Alzheimer's and Huntington's disease. (21212634)
2011
20
Pridopidine in treatment of Huntington's disease: beyond chorea? (22071278)
2011
21
Up-regulation of the isoenzymes MAO-A and MAO-B in the human basal ganglia and pons in Huntington's disease revealed by quantitative enzyme radioautography. (21075085)
2011
22
Growth hormone and ghrelin secretion are associated with clinical severity in Huntington's disease. (19845749)
2010
23
Role of tetrabenazine for Huntington's disease-associated chorea. (20442355)
2010
24
Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease. (19664996)
2009
25
The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease. (19133136)
2009
26
Aripiprazole effects on psychosis and chorea in a patient with Huntington's disease. (18765501)
2008
27
Cross-sectional study on prevalences of psychiatric disorders in mutation carriers of Huntington's disease compared with mutation-negative first-degree relatives. (19026253)
2008
28
Huntington's disease: genetic heterogeneity in black African patients. (18350222)
2008
29
Huntington's disease phenocopies are clinically and genetically heterogeneous. (18181206)
2008
30
Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. (17360721)
2007
31
Dopaminergic signaling and striatal neurodegeneration in Huntington's disease. (17652581)
2007
32
Hypocretin-1 and secondary signs in Huntington's disease. (18267269)
2007
33
Ubiquitin-proteasome system alterations in a striatal cell model of Huntington's disease. (17455294)
2007
34
The platelet maximum number of A2A-receptor binding sites (Bmax) linearly correlates with age at onset and CAG repeat expansion in Huntington's disease patients with predominant chorea. (16221531)
2006
35
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. (16537516)
2006
36
Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease. (15567511)
2005
37
Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis. (14627700)
2004
38
Spinocerebellar ataxia type 17 repeat in patients with Huntington's disease-like and ataxia. (15236416)
2004
39
In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease. (12559971)
2003
40
Progressive striatal and cortical dopamine receptor dysfunction in Huntington's disease: a PET study. (12690052)
2003
41
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. (11906693)
2002
42
The molecular biology of Huntington's disease. (11200958)
2001
43
Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. (11406612)
2001
44
Are there multiple pathways in the pathogenesis of Huntington's disease? (10434298)
1999
45
Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. (9121555)
1997
46
Cognitive assessment of asymptomatic Huntington's disease carriers]. (9303588)
1997
47
The cortical neuritic pathology of Huntington's disease. (7770116)
1995
48
Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in disease prevalence. (7951324)
1994
49
A new polymerase chain reaction (PCR) assay for the trinucleotide repeat that is unstable and expanded on Huntington's disease chromosomes. (8366869)
1993
50
Retrograde amnesia in patients with Alzheimer's disease or Huntington's disease. (2967441)
1988

Genetic Variations for Huntington's Disease

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Expression for genes affiliated with Huntington's Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Huntington's Disease

Search GEO for disease gene expression data for Huntington's Disease.

Pathways for genes affiliated with Huntington's Disease

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 55SinoBiological, 12EMD Millipore
See all sources

Pathways related to Huntington's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2HIP1, HAP1, HTT, CASP8, BDNF
2
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11.2PFN1, CASP2, CASP8, CASP1, BDNF
3
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11.1BDNF, CASP1, CASP8, CASP2
4
Hide members
10.9CASP2, CASP8, CASP1
5
Hide members
10.9CASP2, CASP8, CASP1
6
Hide members
10.9CASP1, CASP8, CASP2
7
Hide members
10.9CASP2, CASP8, CASP1
810.9CASP2, CASP8, CASP1
9
Hide members
10.9CASP1, CASP8, CASP2
10
Apoptosis and survival Caspase cascade
Hide members
10.9CASP2, CASP8, CASP1

Compounds for genes affiliated with Huntington's Disease

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB
See all sources

Compounds related to Huntington's Disease according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1atp44 2813.3BDNF, CASP1, CALB1, CASP2, UBE2K, HTT
2tyrosine4412.2BDNF, CASP1, CASP8, CALB1, UBE2K, HTT
3oxygen44 2413.1BDNF, CASP1, CASP8, CASP2, HTT, PRNP
4lipid4412.1BDNF, CASP1, CASP2, HTT, PRNP, HIP1
5h2o24412.0BDNF, CASP1, CASP8, CASP2, UBE2K, PRNP
6retinoic acid44 2412.9BDNF, CASP1, CASP8, CALB1, CASP2, HTT
7superoxide44 2412.8CASP1, CASP8, CASP2, HTT, PRNP, SETD2
8testosterone44 59 11 2414.8BDNF, CASP1, CALB1, CASP2, HTT, SETD2
9glutamate4411.7BDNF, CASP1, CALB1, HTT, PRNP, KMO
10serine4411.7BDNF, CASP1, CASP8, CASP2, HTT, PRNP
11quinolinic acid44 2412.7KMO, QPRT, HTT, CALB1, BDNF
12camptothecin44 59 1113.7BDNF, CASP1, CASP8, CASP2, SETD2
13butyrate4411.6CASP1, CASP8, CASP2, HTT, SETD2
14paclitaxel44 49 1113.6BDNF, CASP1, CASP8, CASP2, SETD2
15cysteine4411.6CASP1, CASP8, CASP2, UBE2K, HTT, DNAJC5
16doxorubicin44 49 1113.6BDNF, CASP1, CASP8, CASP2, SETD2
17actinomycin d4411.6BDNF, CASP1, CASP8, UBE2K, SETD2
18glucose4411.6BDNF, CASP1, CALB1, HTT, SLC2A4RG, SETD2
19proline4411.6SETD2, PFN1, PRNP, HTT, BDNF
20glutamine4411.6CASP1, CASP2, HTT, HAP1, HIP1
21cisplatin44 49 59 1114.6BDNF, CASP1, CASP8, CASP2, SETD2
22nmda44 2812.5KMO, HTT, CASP1, BDNF
23arsenite44 2412.5CASP1, CASP8, CASP2, SETD2
24etoposide44 49 59 1114.4SETD2, CASP2, CASP8, CASP1
25n acetylcysteine4411.4BDNF, CASP1, CASP8, SETD2
26sb 20358044 5912.4SETD2, PRNP, CASP8, CASP1
27z-dqmd-fmk59 2812.4CASP1, CASP8, CASP2
28az 104178085911.4CASP1, CASP8, CASP2
29z-devd-fmk59 2812.4CASP1, CASP8, CASP2
30z-vad-fmk44 5912.3CASP1, CASP8, CASP2
31mevalonate4411.3CASP1, CASP8, CASP2
32tetrapeptide4411.3CASP1, CASP8, CASP2
33melatonin44 59 28 11 2415.2BDNF, CASP2, HTT
34tetracycline44 1112.2PRNP, CASP8, CASP1
35anisomycin44 1112.2BDNF, CASP1, CASP8
36it 154411.2JPH3, HTT
37adpribose4411.1CASP2, CASP8, CASP1
38pd 98,0594411.1BDNF, CASP1, CASP8, SETD2
39cystamine4411.1HTT, BDNF
40kainate44 2812.1BDNF, CALB1, HTT
41n-acetylaspartate4411.1CALB1, BDNF
423-nitropropionic acid4411.1BDNF, HTT
43sp 60012544 5912.1SETD2, CASP2, CASP8
44wortmannin4411.1BDNF, CASP8, CASP2, SETD2
45potassium44 11 2413.1CASP2, CALB1, CASP1, BDNF
46lead4411.0SETD2, CASP2, BDNF
47oligonucleotide4410.9CASP1, CALB1, CASP2, HTT, SETD2
48sodium nitroprusside4410.8SETD2, CASP8, CASP1

GO Terms for genes affiliated with Huntington's Disease

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Sources:
16Gene Ontology
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Cellular components related to Huntington's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.1CALB1, CASP2, HTT, PRNP, HIP1, PFN1
2cytoskeletonGO:00585610.8PFN1, HIP1, HAP1, CASP8

Biological processes related to Huntington's Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1learning or memoryGO:00761111.1PRNP, CALB1, BDNF
2cellular response to mechanical stimulusGO:07126011.1CASP1, CASP8, CASP2
3activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691911.0HIP1, CASP8, CASP1
4quinolinate biosynthetic processGO:01980511.0KMO, HTT
5vesicle transport along microtubuleGO:04749610.8HTT, HAP1
6negative regulation of neuron apoptotic processGO:04352410.8BDNF, HTT, DNAJC5
7NAD biosynthetic processGO:00943510.8KMO, QPRT
8cellular response to organic substanceGO:07131010.8CALB1, CASP1
9apoptotic signaling pathwayGO:09719010.6HIP1, CASP2, CASP8

Molecular functions related to Huntington's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.3UBE2K, CASP2, CALB1, CASP8, HTT, HAP1
2cysteine-type endopeptidase activityGO:00419710.8CASP2, CASP8, CASP1
3ATP-dependent protein bindingGO:04300810.5DNAJC5, PRNP

Products for genes affiliated with Huntington's Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Huntington's Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet