Huntington's Disease (HD) malady

Genetic diseases, Rare diseases, Neuronal diseases categories
Download this MalaCard

Summaries for Huntington's Disease

About this section

Fully expand this MalaCard
NINDS:43 Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.

MalaCards based summary: Huntington's Disease, also known as huntington disease, is related to motor neuron disease and spinocerebellar ataxia, and has symptoms including abnormal cry/voice/phonation disorder/nasal speech, cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy and eeg anomalies. An important gene associated with Huntington's Disease is HTT (huntingtin), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Apoptotic Pathways in Synovial Fibroblasts. The drugs baclofen and coenzyme q10 and the compounds it 15 and axokine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are taste/olfaction and no phenotypic analysis.

Disease Ontology:8 A neurodegenerative disease and an autosomal dominant disease that is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has material basis in expansion of cag triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.

Genetics Home Reference:21 Huntington disease is a progressive brain disorder that causes uncontrolled movements, emotional problems, and loss of thinking ability (cognition).

NIH Rare Diseases:42 Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain.  this results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. symptoms typically appear between the ages of 35 and 44 years. people with huntington disease most often live for 15 to 18 years after the condition appears. huntington disease caused by mutations in the htt gene and is inherited in an autosomal dominant manner. each child of a person with huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. there is also a less common, early-onset from that begins in childhood or adolescence, called juvenile huntington disease. last updated: 6/27/2011

MedlinePlus:33 Huntington's disease (hd) is an inherited disease that causes certain nerve cells in the brain to waste away. people are born with the defective gene, but symptoms usually don't appear until middle age. early symptoms of hd may include uncontrolled movements, clumsiness, and balance problems. later, hd can take away the ability to walk, talk, and swallow. some people stop recognizing family members. others are aware of their environment and are able to express emotions. if one of your parents has huntington's disease, you have a 50 percent chance of getting it. a blood test can tell you if have the hd gene and will develop the disease. genetic counseling can help you weigh the risks and benefits of taking the test. there is no cure. medicines can help manage some of the symptoms, but cannot slow down or stop the disease. nih: national institute of neurological disorders and stroke

Wikipedia:65 Huntington\'s disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and... more...

Description from OMIM:46 143100

GeneReviews summary for huntington

Aliases & Classifications for Huntington's Disease

About this section
30LifeMap Discovery®, 8Disease Ontology, 65Wikipedia, 42NIH Rare Diseases, 21Genetics Home Reference, 43NINDS, 33MedlinePlus, 9diseasecard, 19GeneReviews, 20GeneTests, 46OMIM, 44Novoseek, 48Orphanet, 62UMLS, 22GTR, 10DISEASES, 27ICD9CM, 34MeSH, 57SNOMED-CT, 39NCIt, 63UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Huntington's Disease, Aliases & Descriptions:

Name: Huntington's Disease 30 8 65 42 21 43 33
Huntington Disease 8 9 19 42 20 21 46 44 48 62
Huntington Chorea 19 22 21 48
Huntington's Chorea 8 42 21
Huntington Chronic Progressive Hereditary Chorea 21 62
Juvenile Huntington Disease 48 62
Juvenile Huntington Chorea 48 62
Hd 8 42
Progressive Chorea, Chronic Hereditary 65
Huntingtons Disease 10
Jhd 48


Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases

Characteristics (Orphanet epidemiological data):

huntington disease:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age
juvenile huntington disease:
Inheritance: Autosomal dominant; Prevalence: 1-9/1000000; Age of onset: Adolescence / Young adulthood

External Ids:

Disease Ontology8 DOID:12858
ICD9CM27 333.4
MeSH34 D006816
NCIt39 C82342
OMIM46 143100
SNOMED-CT57 155006000, 58756001
UMLS via Orphanet63 C0020179, C0751208
MESH via Orphanet35 D006816
ICD10 via Orphanet26 G10
ICD1025 G10

Related Diseases for Huntington's Disease

About this section

Diseases in the Huntington's Disease family:

Huntington Disease-Like 2 Juvenile Huntington Disease
Huntington Disease-Like 1 Huntington Disease-Like Syndrome
Huntington Disease-Like 3 Huntington Disease-Like Syndrome Due to C9orf72 Expansions

Diseases related to Huntington's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1motor neuron disease30.9HTT, CNTF, BDNF
2spinocerebellar ataxia30.7ATN1, PRNP, HTT, TBP
3machado-joseph disease30.6TBP, HTT, ATN1
4memory impairment30.5PRNP, CNR1, CALB1, BDNF
5prion disease30.5PRNP, HTT, CNR1, BDNF
6spinocerebellar ataxia type 1730.5TBP, ATN1, JPH3
7dentatorubral-pallidoluysian atrophy30.5JPH3, ATN1, HTT, TBP
8schizophrenia30.5ATN1, HCRT, CNR1, CNTF, CALB1, TBP
9ischemia30.4BLVRB, HCRT, KMO, CNR1, CNTF, CASP1
10dementia30.3HAP1, HCRT, PRNP, HTT, TBP, BDNF
11breast cancer29.8PFN1, HTT, CNR1, CASP8, CASP1, SLC2A3
12huntington disease-like 210.5
13parkinson's disease10.5BDNF, CNR1
14cannabis dependence10.5CNR1
15olivopontocerebellar atrophy10.5ATN1, HTT
16temporal lobe epilepsy10.5PRNP, CALB1, BDNF
17toxic encephalopathy10.5PRNP, HTT, BDNF
18neuroblastoma10.5BDNF, PRNP
19status epilepticus10.5BDNF, CNR1
20obsessive-compulsive disorder10.4BDNF
21hereditary ataxia10.4ATN1, TBP
22spinocerebellar ataxia type 1210.4ATN1, PRNP, TBP
23eating disorder10.4HCRT, CNR1, BDNF
24psychotic disorder10.4CNR1, CNTF, BDNF
25progressive supranuclear palsy10.4HCRT, PRNP
26anorexia nervosa10.4BDNF, CNR1, HCRT
27drug addiction10.4HCRT, BDNF
28encephalitis10.4CNR1, CNTF, CALB1
29mood disorder10.4HCRT, CNR1, BDNF
30bipolar disorder10.4CNR1, CALB1, BDNF
31cowpox10.4CASP1, CASP8
32herpes simplex10.4CASP1, CALB1, TBP, BDNF
33central nervous system disease10.4HCRT, CNR1, CNTF, BDNF
34huntington disease-like 110.3
35cerebrovascular disease10.3CASP1, CNTF, CNR1, PRNP
36epilepsy syndrome10.3BLVRB, PRNP, CNR1, CALB1, BDNF
37cholera10.3BLVRB, PRNP, CNR1
38demyelinating disease10.3CNTF, HCRT
39huntington disease-like 310.3
40huntington disease-like syndrome due to c9orf72 expansions10.3
41sensory peripheral neuropathy10.3CNTF, BDNF
42juvenile huntington disease10.3
43ipex syndrome10.3BLVRB, PRNP, CNTF, CALB1, TBP
44hypoglycemia10.2HCRT, BDNF, SLC2A3
45amyotrophic lateral sclerosis type 1410.2BLVRB, PRNP, HTT, CNR1, CNTF, CASP1
47brain cancer10.2HCRT, CNTF, CASP8, SLC2A3
48astrocytoma10.2PRNP, CNR1, CASP8, SLC2A3
49multiple sclerosis10.2BLVRB, HCRT, CNR1, CNTF, CASP8, CASP1
50fragile x syndrome10.2

Graphical network of the top 20 diseases related to Huntington's Disease:

Diseases related to huntington's disease

Symptoms for Huntington's Disease

About this section

Symptoms by clinical synopsis from OMIM:


Clinical features from OMIM:



48 (show all 8)
  • abnormal cry/voice/phonation disorder/nasal speech
  • cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy
  • eeg anomalies
  • movement disorder
  • hypertonia/spasticity/rigidity/stiffness
  • psychic/psychomotor regression/dementia/intellectual decline
  • psychic/behavioural troubles
  • autosomal dominant inheritance

HPO human phenotypes related to Huntington's Disease:

(show all 18)
id Description Frequency HPO Source Accession
1 behavioral abnormality typical (50%) HP:0000708
2 hypertonia typical (50%) HP:0001276
3 abnormality of the voice typical (50%) HP:0001608
4 cerebral cortical atrophy typical (50%) HP:0002120
5 eeg abnormality typical (50%) HP:0002353
6 developmental regression typical (50%) HP:0002376
7 abnormality of movement typical (50%) HP:0100022
8 autosomal dominant inheritance HP:0000006
9 abnormality of eye movement HP:0000496
10 depression HP:0000716
11 dementia HP:0000726
12 personality changes HP:0000751
13 hyperreflexia HP:0001347
14 rigidity HP:0002063
15 bradykinesia HP:0002067
16 chorea HP:0002072
17 gliosis HP:0002171
18 neuronal loss in central nervous system HP:0002529

Drugs & Therapeutics for Huntington's Disease

About this section

Drug clinical trials:

Search ClinicalTrials for Huntington's Disease

Search NIH Clinical Center for Huntington's Disease

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Huntington's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Huntington's Disease:
Embryonic stem cell-derived GABA progenitor cells for treatment of Huntington's disease
Embryonic/Adult Cultured Cells Related to Huntington's Disease:
Lateral Ganglionic Eminence progenitors, PMID: 22424902

Genetic Tests for Huntington's Disease

About this section

Genetic tests related to Huntington's Disease:

id Genetic test Affiliating Genes
1 Huntington Disease20 HTT
2 Huntington's Chorea22

Anatomical Context for Huntington's Disease

About this section

MalaCards organs/tissues related to Huntington's Disease:

Brain, Testes, Cortex, Prefrontal cortex, Breast, Globus pallidus, Caudate nucleus, Heart, Skeletal muscle, Thyroid, Skin, Eye, Cerebellum, Pons, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Huntington's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BrainStriatum  Affected by disease

Animal Models for Huntington's Disease or affiliated genes

About this section

MGI Mouse Phenotypes related to Huntington's Disease:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539410.1BDNF, CNR1, HTT
2MP:00030129.6ATN1, PRNP, HTT, CNR1, CNTF, TBP
3MP:00053899.5JPH3, ATN1, PRNP, HTT, CNR1, CASP1
4MP:00028739.5ATN1, SETDB1, PFN1, PRNP, HTT, CNR1
5MP:00107719.4HAP1, PFN1, HTT, CNR1, CASP8, CASP1
6MP:00053849.3SETDB1, PFN1, PRNP, HTT, CNR1, CNTF
7MP:00053809.2HAP1, SETDB1, PFN1, HTT, CASP8, TBP
8MP:00053789.0PFN1, HCRT, ATN1, JPH3, HAP1, PRNP
9MP:00053869.0HAP1, JPH3, ATN1, HCRT, PFN1, PRNP
10MP:00053769.0HTT, PRNP, PFN1, HCRT, HAP1, CNR1
11MP:00107688.9PFN1, SETDB1, ATN1, JPH3, HAP1, PRNP
12MP:00036318.6SLC2A3, HAP1, JPH3, ATN1, HCRT, SETDB1

Publications for Huntington's Disease

About this section

Articles related to Huntington's Disease:

(show top 50)    (show all 1108)
Sexually dimorphic dopaminergic dysfunction in a transgenic mouse model of Huntington's disease. (25316307)
Physical therapy in Huntington's disease--toward objective assessments? (22672573)
Differential effects of early environmental enrichment on emotionality related behaviours in Huntington's disease transgenic mice. (23045340)
Oral and dental health in Huntington's disease - an observational study. (24138900)
Huntington's disease gene expansion associates with early onset nonprogressive chorea. (23536475)
Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records. (23482661)
Multiple Aspects of Gene Dysregulation in Huntington's Disease. (24167500)
Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease. (24324398)
The pridopidine paradox in Huntington's disease. (23847099)
Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells. (24041806)
Dose-dependent neuroprotection of VEGFa88a88a88 in Huntington's disease striatum. (23799534)
Functional magnetic resonance imaging of working memory in Huntington's disease: Cross-sectional data from the IMAGE-HD study. (23913754)
Cognitive reserve and brain reserve in prodromal Huntington's Disease. (23702309)
Noninvasive brain stimulation in Huntington's disease. (24112923)
Neuroprotective effects of PPAR-I^ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease. (23373812)
Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease. (22466800)
High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model. (23346268)
Network methods for describing sample relationships in genomic datasets: application to Huntington's disease. (22691535)
Echolalia or functional repetition in conversation--a case study of an individual with Huntington's disease. (20831380)
Spermine improves recognition memory deficit in a rodent model of Huntington's disease. (19632348)
Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. (19193873)
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. (18558632)
AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease. (18065778)
Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease. (18192679)
Early cognitive deficits in Swedish gene carriers of Huntington's disease. (17201528)
Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. (17360721)
Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain. (16487146)
Short G-rich oligonucleotides as a potential therapeutic for Huntington's Disease. (17014717)
Purification of neuronal inclusions of patients with Huntington's disease reveals a broad range of N-terminal fragments of expanded huntingtin and insoluble polymers. (16181417)
Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease. (16263095)
Incidence and mutation rates of Huntington's disease in Spain: experience of 9 years of direct genetic testing. (15716522)
Apolipoprotein E genotypes do not influence the age of onset in Huntington's disease. (15548484)
The endocannabinoid system and Huntington's disease. (14529364)
Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease. (11870213)
CAG mutation effect on rate of progression in Huntington's disease. (12548366)
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease. (12165556)
Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation. (12097329)
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. (11988536)
Wild-type huntingtin up-regulates BDNF transcription in Huntington's disease. (11697536)
Benzodiazepine receptor quantification in Huntington's disease with [(123)I]omazenil and SPECT. (11309461)
The early cellular pathology of Huntington's disease. (10966117)
Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin. (10434304)
Huntington aggregates may not predict neuronal death in Huntington's disease. (10589536)
The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. (9734812)
A single allele from the polymorphic CCG rich sequence immediately 3' to the unstable CAG trinucleotide in the IT15 cDNA shows almost complete disequilibrium with Huntington's disease chromosomes in the Scottish population. (8162020)
Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in disease prevalence. (7951324)
A new polymerase chain reaction (PCR) assay for the trinucleotide repeat that is unstable and expanded on Huntington's disease chromosomes. (8366869)
Brain muscarinic cholinergic receptors in Huntington's disease. (1532417)
The psychopathology of Huntington's disease. (1825887)
Synaptophysin expression in the striatum in Huntington's disease. (2141751)

Variations for Huntington's Disease

About this section

Clinvar genetic disease variations for Huntington's Disease:

id Gene Name Type Significance SNP ID Assembly Location
1HTTNM_002111.6(HTT)NT expansionPathogenicrs193922950GRCh37Chr 4, 3076603: 3076660
2HTTNM_002111.6(HTT)NT expansionPathogenicrs193922951GRCh37Chr 4, 3076603: 3076660
3HTTNP_002102.4: p.Gln40(41_?)indelPathogenicGRCh37Chr 4, 3076604: 3076660

Expression for genes affiliated with Huntington's Disease

About this section
Expression patterns in normal tissues for genes affiliated with Huntington's Disease

Search GEO for disease gene expression data for Huntington's Disease.

Pathways for genes affiliated with Huntington's Disease

About this section

Compounds for genes affiliated with Huntington's Disease

About this section

Compounds related to Huntington's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1it 154410.5HTT, ATN1, JPH3
2axokine4410.5CNR1, CNTF, BDNF
3cystamine4410.4HTT, BDNF
4methamphetamine44 50 1112.3BDNF, CALB1, CNTF
5quinine44 28 2 50 1114.3BLVRB, KMO, BDNF
6amphetamine44 50 1112.3CNTF, CNR1, HCRT
7tetrodotoxin44 61 2812.2BDNF, CALB1, CNR1, HCRT
8cocaine44 1111.2HCRT, CNR1, CNTF, BDNF
9catecholamine4410.2BDNF, CNTF, HCRT, BLVRB
10glyceraldehyde 3-phosphate4410.2ATN1, PFN1, HTT, TBP
11n-acetylaspartate4410.2CALB1, BDNF
12thapsigargin44 6111.2HCRT, CNR1, CASP8, CASP1, BDNF
133-nitropropionic acid4410.1BDNF, HTT
14choline44 24 1112.1BDNF, CALB1, CNTF, BLVRB
15proline4410.1BDNF, TBP, HTT, PRNP, PFN1
16formaldehyde44 2411.1BLVRB, PRNP, CALB1, TBP
17kainate44 2811.1BLVRB, HTT, CNR1, CALB1, BDNF
18ethanol44 50 24 1113.1BLVRB, HCRT, CASP1, BDNF, SLC2A3
19n acetylcysteine4410.1BDNF, CASP1, CASP8, CNTF
20histamine44 28 2412.1HCRT, CNR1, CNTF, CASP1, BDNF
21melatonin44 28 61 24 1114.1BDNF, HTT, HCRT
22glutamine4410.0HAP1, ATN1, HTT, CASP1, TBP
23cycloheximide4410.0CNTF, CASP8, CASP1, BDNF, SLC2A3
24iron44 2411.0BDNF, TBP, HTT, PRNP, BLVRB
25norepinephrine44 24 1112.0HCRT, CNR1, CNTF, CALB1, BDNF
26superoxide44 2411.0BLVRB, PRNP, HTT, CNTF, CASP8, CASP1
27histidine4410.0TBP, CASP1, CNTF, PRNP
28h2o2449.9PRNP, CNTF, CASP8, CASP1, BDNF
29cyclic amp44 2410.9BDNF, TBP, CNTF, CNR1, HCRT
31acetylcholine44 50 28 24 1113.9BLVRB, HCRT, CNR1, CNTF, CALB1, BDNF
32adenylate449.9BLVRB, HCRT, CNR1, CNTF, TBP, BDNF
33octadecaneuropeptide449.8CNTF, HCRT
34alanine449.8HCRT, PRNP, HTT, CNR1, CNTF, CASP8
35retinoic acid44 2410.8HTT, CNTF, CASP8, CASP1, CALB1, TBP
36quinolinic acid44 2410.8BDNF, BLVRB, HCRT, KMO, HTT, CNTF
37cysteine449.8TBP, CASP1, CASP8, CNR1, HTT, ATN1
38nitric oxide44 24 1111.8BLVRB, HCRT, HTT, CNTF, CASP1, CALB1
39dopamine44 28 24 1112.8BLVRB, HCRT, HTT, CNR1, CNTF, CALB1
40lipid449.7HCRT, PFN1, PRNP, HTT, CNR1, CNTF
41potassium44 24 1111.7BLVRB, HCRT, CNTF, CASP1, CALB1, TBP
42serine449.7PRNP, HTT, CNR1, CNTF, CASP8, CASP1
43nmda44 2810.7BLVRB, HCRT, KMO, HTT, CNR1, CASP1
44oxygen44 2410.7BLVRB, KMO, PRNP, HTT, CASP8, CASP1
45testosterone44 61 24 1112.6ATN1, BLVRB, HCRT, HTT, CNTF, CASP1
46atp44 2810.5BLVRB, HCRT, PFN1, PRNP, HTT, CASP1
47calcium44 50 24 1112.4BLVRB, HCRT, PRNP, HTT, CNR1, CNTF
48glutamate449.4BLVRB, HCRT, KMO, PRNP, HTT, CNR1
49glucose449.3CNR1, HTT, HCRT, BLVRB, CNTF, CASP1
50tyrosine449.3PRNP, HCRT, BLVRB, ATN1, HTT, CNTF

GO Terms for genes affiliated with Huntington's Disease

About this section

Cellular components related to Huntington's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:0057419.8KMO, PRNP, CASP8
2nucleusGO:0056348.9BLVRB, SETDB1, PFN1, PRNP, HTT, ZNF395
3cytoplasmGO:0057378.5SLC2A4RG, ATN1, BLVRB, SETDB1, PRNP, HTT

Biological processes related to Huntington's Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1quinolinate biosynthetic processGO:01980510.4KMO, HTT
2regulation of retinal cell programmed cell deathGO:04666810.4BDNF, CNTF
3vesicle transport along microtubuleGO:04749610.3HTT, HAP1
4learning or memoryGO:00761110.2BDNF, CALB1, PRNP
5execution phase of apoptosisGO:09719410.2CASP1, CASP8
6negative regulation of neuron apoptotic processGO:04352410.2HTT, CNTF, BDNF
7response to lipopolysaccharideGO:03249610.0CNR1, CASP8, CASP1
8cellular response to organic substanceGO:07131010.0CALB1, CASP1
9regulation of excitatory postsynaptic membrane potentialGO:0600799.9BDNF, HCRT

Products for genes affiliated with Huntington's Disease

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Huntington's Disease

About this section
26ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
58SNOMED-CT via Orphanet
63UMLS via Orphanet