HD
MCID: HNT001
MIFTS: 81

Huntington's Disease (HD) malady

Neuronal category

Summaries for Huntington's Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
See all sources

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NINDS:44 Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.

MalaCards: Huntington's Disease, also known as huntington disease, is related to huntington disease-like 2 and dentatorubral-pallidoluysian atrophy, and has symptoms including abnormal cry/voice/phonation disorder/nasal speech, cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy and eeg anomalies. An important gene associated with Huntington's Disease is HTT (huntingtin), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Apoptotic Pathways in Synovial Fibroblasts. The drugs baclofen and perphenazine and the compounds atp and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are nervous system and mortality/aging.

Disease Ontology:8 A neurodegenerative disease that has material basis in expansion of cag repeats resulting in neuron degeneration affecting muscle coordination, cognitive abilities.

NIH Rare Diseases:43 Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain.  this results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. symptoms typically appear between the ages of 35 and 44 years. people with huntington disease most often live for 15 to 18 years after the condition appears. huntington disease caused by mutations in the htt gene and is inherited in an autosomal dominant manner. each child of a person with huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. there is also a less common, early-onset from that begins in childhood or adolescence, called juvenile huntington disease. last updated: 6/27/2011

MedlinePlus:34 Huntington's disease (hd) is an inherited disease that causes certain nerve cells in the brain to waste away. people are born with the defective gene, but symptoms usually don't appear until middle age. early symptoms of hd may include uncontrolled movements, clumsiness, and balance problems. later, hd can take away the ability to walk, talk, and swallow. some people stop recognizing family members. others are aware of their environment and are able to express emotions. if one of your parents has huntington's disease, you have a 50 percent chance of getting it. a blood test can tell you if have the hd gene and will develop the disease. genetic counseling can help you weigh the risks and benefits of taking the test. there is no cure. medicines can help manage some of the symptoms, but cannot slow down or stop the disease. nih: national institute of neurological disorders and stroke

Genetics Home Reference:21 Huntington disease is a progressive brain disorder that causes uncontrolled movements, emotional problems, and loss of thinking ability (cognition).

Wikipedia:64 Huntington\'s disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and... more...

Description from OMIM:47 143100

GeneReviews summary for huntington

Aliases & Classifications for Huntington's Disease

Sources:
8Disease Ontology, 9diseasecard, 64Wikipedia, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 44NINDS, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 27ICD9CM, 35MeSH, 57SNOMED-CT, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
huntington disease:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age
juvenile huntington disease:
Inheritance: Autosomal dominant; Prevalence: 1-9/1000000; Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

huntington's disease 8 64 43 21 44 34 31
huntington disease 9 19 43 20 21 47 45 49 61
huntington chorea 19 22 21 49
huntington's chorea 8 43 21
juvenile huntington disease 49 61
hd 8 43
huntington chronic progressive hereditary chorea 21
progressive chorea, chronic hereditary 64
huntington's disease pathway 8
juvenile huntington chorea 49
huntingtons disease 10
jhd 49


External Ids:

Disease Ontology8 DOID:12858
ICD9CM27 333.4
MeSH35 D006816
OMIM47 143100
NCIt40 C82342
SNOMED-CT57 58756001, 155006000
MESH via Orphanet36 D006816
ICD10 via Orphanet26 G10
SNOMED-CT via Orphanet58 58756001, 230299004
UMLS via Orphanet62 C0020179, C0751208
ICD1025 G10

Related Diseases for Huntington's Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Huntington's Disease family:

huntington disease-like 2 juvenile huntington disease
huntington disease-like 1 huntington disease-like syndrome
huntington disease-like 3

Diseases related to Huntington's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1huntington disease-like 230.6JPH3
2dentatorubral-pallidoluysian atrophy30.0PRNP, JPH3, HTT
3memory impairment30.0PRNP, CALB1, BDNF
4brain disease10.5
5huntington disease-like 110.4
6huntington disease-like 310.3
7juvenile huntington disease10.3
8normal pressure hydrocephalus10.1
9ataxia10.1
10attention deficit hyperactivity disorder10.1
11conduct disorder10.1
12infectious mononucleosis10.1
13alzheimer's disease10.0BDNF, CASP1, CALB1, CASP2, HTT, PRNP
14breast cancer10.0CASP1, CASP8, CASP2, HTT, PFN1, SETD2
15parkinson's disease10.0BDNF, CASP8, CALB1, HTT, PRNP
16ischemia10.0BDNF, CASP1, CASP2, KMO, SETD2
17amyotrophic lateral sclerosis10.0BDNF, CASP1, HTT, PRNP
18dementia10.0BDNF, HTT, HAP1, PRNP
19astrocytoma10.0CASP8, CASP2, PRNP, SETD2
20epilepsy syndrome10.0BDNF, CALB1, CASP2, PRNP
21toxic encephalopathy10.0BDNF, HTT, PRNP
22temporal lobe epilepsy10.0BDNF, CALB1, PRNP
23multiple sclerosis10.0CASP8, CASP1, BDNF
24pancreatic cancer10.0BDNF, CASP1, CASP8, SETD2
25multiple system atrophy10.0PRNP, HTT
26prion disease10.0BDNF, HTT, PRNP
27colon cancer10.0CASP1, CASP8, SETD2
28ovarian cancer10.0SETD2, CASP2, CASP8, CASP1
29neuroblastoma10.0PRNP, BDNF
30machado-joseph disease10.0
31hereditary spastic paraplegia10.0
32leber hereditary optic neuropathy10.0
33lipoid proteinosis10.0
34chorea-acanthocytosis10.0
35spinocerebellar ataxia10.0
36substance abuse10.0
37testicular disease10.0
38acanthocytosis10.0
39tardive dyskinesia10.0
40mental retardation10.0
41cerebral atrophy10.0
42dentatorubral atrophy10.0
43dysphagia10.0
44swallowing disorders10.0
45tremor10.0
46mcleod syndrome with or without chronic granulomatous disease10.0
47lip disease10.0
48motor neuron disease10.0HTT, BDNF
49pancreatitis10.0CASP1
50encephalitis10.0CALB1

Graphical network of the top 20 diseases related to Huntington's Disease:



Diseases related to huntington's disease

Clinical Features for Huntington's Disease

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

143100

Clinical synopsis from OMIM:

143100

Symptoms:

49 (show all 8)
  • abnormal cry/voice/phonation disorder/nasal speech
  • cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy
  • eeg anomalies
  • movement disorder
  • hypertonia/spasticity/rigidity/stiffness
  • psychic/psychomotor regression/dementia/intellectual decline
  • psychic/behavioural troubles
  • autosomal dominant inheritance

Drugs & Therapeutics for Huntington's Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Huntington's Disease

Drug clinical trials:

Search ClinicalTrials for Huntington's Disease

Search NIH Clinical Center for Huntington's Disease

Search CenterWatch for Huntington's Disease

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Huntington's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Huntington's Disease:
Embryonic stem cell-derived GABA progenitor cells for treatment of Huntington's disease
Embryonic/Adult Cultured Cells Related to Huntington's Disease:
Lateral Ganglionic Eminence progenitors, PMID: 22424902

Genetic Tests for Huntington's Disease

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Huntington's Disease:

id Genetic test Affiliating Genes
1 Huntington Disease20 HTT
2 Huntington's Chorea22

Anatomical Context for Huntington's Disease

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Huntington's Disease:

33
Whole blood, Brain, Cortex, Heart, Thyroid, Breast, Skin, T cells, B lymphoblasts, B cells, Fetal brain, Prefrontal cortex, Ciliary ganglion, Globus pallidus, Fetal thyroid, Adrenal cortex, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Huntington's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BrainStriatum  Affected by disease

Animal Models for Huntington's Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Huntington's Disease

Sources:
51PubMed
See all sources

Articles related to Huntington's Disease:

(show top 50)    (show all 604)
idTitleAuthorsYear
1
Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in vivo. (24021477)
2014
2
Nigral involvement and nigrostriatal dysfunction in Huntington's disease: evidences from an MRI and SPECT study. (23769177)
2013
3
A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice. (24278347)
2013
4
In vitro and in vivo models of Huntington's disease show alterations in the endocannabinoid system. (23659592)
2013
5
Is gardening a stimulating activity for people with advanced Huntington's disease? (24339085)
2013
6
Prefrontal activity in Huntington's disease reflects cognitive and neuropsychiatric disturbances: the IMAGE-HD study. (23123406)
2013
7
Choosing an animal model for the study of Huntington's disease. (24052178)
2013
8
Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease. (23385980)
2013
9
Decreased Metabolism in the Cerebral Cortex in Early-Stage Huntington's Disease: A Possible Biomarker of Disease Progression? (23346156)
2013
10
Study of oxidative damage and antioxidant systems in two Huntington's disease rodent models. (23754226)
2013
11
Caregiver roles in families affected by Huntington's disease: a qualitative interview study. (24237139)
2013
12
Modelling and inference reveal nonlinear length-dependent suppression of somatic instability for small disease associated alleles in myotonic dystrophy type 1 and Huntington disease. (24047873)
2013
13
Clinical significance of frontal cortex abnormalities in Huntington's disease. (23562669)
2013
14
Synergistical neuroprotection of rofecoxib and statins against malonic acid induced Huntington's disease like symptoms and related cognitive dysfunction in rats. (23562615)
2013
15
Pathways to decoding the clinical potential of stress response FOXO-interaction networks for Huntington's disease: of gene prioritization and context dependence. (23781200)
2013
16
Functional and connectivity changes during working memory in Huntington's disease: 18 month longitudinal data from the IMAGE-HD study. (23938592)
2013
17
The structural correlates of functional deficits in early huntington's disease. (22438242)
2013
18
Depressive symptoms in prodromal Huntington's Disease correlate with Stroop-interference related functional connectivity in the ventromedial prefrontal cortex. (22974690)
2012
19
Aberrant heart rate and brainstem brain-derived neurotrophic factor (BDNF) signaling in a mouse model of Huntington's disease. (22209255)
2012
20
"How sick must your mouse be? " - An analysis of the use of animal models in Huntington's disease research. (23215663)
2012
21
Does Huntington's disease enhance cephalad spread during neuraxial anesthesia for cesarean section? (22986328)
2012
22
Witchcraft and Huntington's disease: a salutary history of societal and medical stigmatisation. (23014122)
2012
23
Activating mitochondrial regulator PGC-1I+ expression by astrocytic NGF is a therapeutic strategy for Huntington's disease. (22633948)
2012
24
BDNF may play a differential role in the protective effect of the mGluR2/3 agonist LY379268 on striatal projection neurons in R6/2 Huntington's disease mice. (22820300)
2012
25
Expert evidence by mental health professionals: the communication challenge posed by evidence about Autism Spectrum Disorder, brain injuries, and Huntington's Disease. (23151404)
2012
26
An International Survey-based Algorithm for the Pharmacologic Treatment of Chorea in Huntington's Disease. (21975581)
2011
27
Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea. (21664855)
2011
28
Autonomic dysfunction in presymptomatic and early symptomatic Huntington's disease. (20047567)
2010
29
Hypocretin-1 and secondary signs in Huntington's disease. (18267269)
2007
30
Atypical onset of symptoms in Huntington disease: severe cognitive decline preceding chorea or other motor manifestations. (17159620)
2006
31
The platelet maximum number of A2A-receptor binding sites (Bmax) linearly correlates with age at onset and CAG repeat expansion in Huntington's disease patients with predominant chorea. (16221531)
2006
32
Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease. (16204350)
2005
33
Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease. (15634777)
2005
34
Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice. (14697316)
2004
35
Inhibition of mitochondrial complex II alters striatal expression of genes involved in glutamatergic and dopaminergic signaling: possible implications for Huntington's disease. (15006711)
2004
36
The endocannabinoid system and Huntington's disease. (14529364)
2003
37
Nitric oxide and nitric oxide synthase in Huntington's disease. (11288139)
2001
38
Vesicular neurotransmitter transporters in Huntington's disease: initial observations and comparison with traditional synaptic markers. (11494403)
2001
39
Two novel single-base-pair substitutions adjacent to the CAG repeat in the huntington disease gene (IT15): implications for diagnostic testing. (9915978)
1999
40
Analysis of the subcellular localization of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin: comparison with the distribution of huntingtin in Huntington's disease autopsy brain. (10434306)
1999
41
PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease. (9697113)
1998
42
Transglutaminase action imitates Huntington's disease: selective polymerization of Huntingtin containing expanded polyglutamine. (9660943)
1998
43
A case of Klippel-Trenaunay syndrome associated with Huntington's disease. (9339642)
1997
44
Molecular analysis of the IT15 gene in 79 Spanish families with Huntington's disease: diagnostic confirmation and presymptomatic diagnosis]. (9324583)
1997
45
Genetic screening for Huntington's disease in Chinese patients with involuntary movements. (9491297)
1997
46
Homozygotes and heterozygotes for ciliary neurotrophic factor null alleles do not show earlier onset of Huntington's disease. (9305364)
1997
47
Transplantation of human striatal tissue into a rodent model of Huntington's disease: phenotypic expression of transplanted neurons and host-to-graft innervation. (8846104)
1996
48
Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat. (8197474)
1994
49
Selective vulnerability in Huntington's disease: preferential loss of cannabinoid receptors in lateral globus pallidus. (7944290)
1994
50
Synaptophysin expression in the striatum in Huntington's disease. (2141751)
1990

Genetic Variations for Huntington's Disease

Expression for genes affiliated with Huntington's Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Huntington's Disease

Search GEO for disease gene expression data for Huntington's Disease.

Pathways for genes affiliated with Huntington's Disease

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 56SinoBiological, 12EMD Millipore
See all sources

Pathways related to Huntington's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2HAP1, BDNF, CASP8, HTT, HIP1
2
Hide members
11.2CASP1, CASP2, CASP8, BDNF, PFN1
3
Hide members
11.1CASP2, CASP8, CASP1, BDNF
410.9CASP8, CASP1, CASP2
5
Hide members
10.9CASP1, CASP8, CASP2
6
Hide members
10.9CASP2, CASP8, CASP1
7
Hide members
10.9CASP1, CASP8, CASP2
8
Hide members
10.9CASP8, CASP2, CASP1
9
Hide members
10.9CASP2, CASP8, CASP1
10
Apoptosis and survival Caspase cascade
Hide members
10.9CASP2, CASP1, CASP8

Compounds for genes affiliated with Huntington's Disease

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Huntington's Disease according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1atp45 2913.3BDNF, CASP1, CALB1, CASP2, UBE2K, HTT
2tyrosine4512.2BDNF, CASP1, CASP8, CALB1, UBE2K, HTT
3oxygen45 2413.1BDNF, CASP1, CASP8, CASP2, HTT, PRNP
4lipid4512.1BDNF, CASP1, CASP2, HTT, PRNP, HIP1
5h2o24512.0BDNF, CASP1, CASP8, CASP2, UBE2K, PRNP
6retinoic acid45 2412.9BDNF, CASP1, CASP8, CALB1, CASP2, HTT
7superoxide45 2412.8CASP1, CASP8, CASP2, HTT, PRNP, SETD2
8testosterone45 60 11 2414.8BDNF, CASP1, CALB1, CASP2, HTT, SETD2
9glutamate4511.7BDNF, CASP1, CALB1, HTT, PRNP, KMO
10serine4511.7BDNF, CASP1, CASP8, CASP2, HTT, PRNP
11quinolinic acid45 2412.7KMO, QPRT, HTT, CALB1, BDNF
12camptothecin45 60 1113.7BDNF, CASP1, CASP8, CASP2, SETD2
13butyrate4511.6CASP1, CASP8, CASP2, HTT, SETD2
14paclitaxel45 50 1113.6BDNF, CASP1, CASP8, CASP2, SETD2
15cysteine4511.6CASP1, CASP8, CASP2, UBE2K, HTT, DNAJC5
16doxorubicin45 50 1113.6BDNF, CASP1, CASP8, CASP2, SETD2
17actinomycin d4511.6BDNF, CASP1, CASP8, UBE2K, SETD2
18glucose4511.6BDNF, CASP1, CALB1, HTT, SLC2A4RG, SETD2
19proline4511.6SETD2, PFN1, PRNP, HTT, BDNF
20glutamine4511.6CASP1, CASP2, HTT, HAP1, HIP1
21cisplatin45 50 60 1114.6BDNF, CASP1, CASP8, CASP2, SETD2
22nmda45 2912.5KMO, HTT, CASP1, BDNF
23arsenite45 2412.5CASP1, CASP8, CASP2, SETD2
24etoposide45 50 60 1114.4SETD2, CASP2, CASP8, CASP1
25n acetylcysteine4511.4BDNF, CASP1, CASP8, SETD2
26sb 20358045 6012.4SETD2, PRNP, CASP8, CASP1
27z-dqmd-fmk60 2912.4CASP1, CASP8, CASP2
28az 104178086011.4CASP1, CASP8, CASP2
29z-devd-fmk60 2912.4CASP1, CASP8, CASP2
30z-vad-fmk45 6012.3CASP1, CASP8, CASP2
31mevalonate4511.3CASP1, CASP8, CASP2
32tetrapeptide4511.3CASP1, CASP8, CASP2
33melatonin45 60 29 11 2415.2BDNF, CASP2, HTT
34tetracycline45 1112.2PRNP, CASP8, CASP1
35anisomycin45 1112.2BDNF, CASP1, CASP8
36it 154511.2JPH3, HTT
37adpribose4511.1CASP2, CASP8, CASP1
38pd 98,0594511.1BDNF, CASP1, CASP8, SETD2
39cystamine4511.1HTT, BDNF
40kainate45 2912.1BDNF, CALB1, HTT
41n-acetylaspartate4511.1CALB1, BDNF
423-nitropropionic acid4511.1BDNF, HTT
43sp 60012545 6012.1SETD2, CASP2, CASP8
44wortmannin4511.1BDNF, CASP8, CASP2, SETD2
45potassium45 11 2413.1CASP2, CALB1, CASP1, BDNF
46lead4511.0SETD2, CASP2, BDNF
47oligonucleotide4510.9CASP1, CALB1, CASP2, HTT, SETD2
48sodium nitroprusside4510.8SETD2, CASP8, CASP1

GO Terms for genes affiliated with Huntington's Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Huntington's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.1CASP8, CALB1, CASP2, HTT, PRNP, HIP1
2cytoskeletonGO:00585610.8CASP8, HAP1, HIP1, PFN1

Biological processes related to Huntington's Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1learning or memoryGO:00761111.1PRNP, CALB1, BDNF
2cellular response to mechanical stimulusGO:07126011.1CASP8, CASP1, CASP2
3activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691911.0HIP1, CASP1, CASP8
4quinolinate biosynthetic processGO:01980511.0HTT, KMO
5vesicle transport along microtubuleGO:04749610.8HAP1, HTT
6negative regulation of neuron apoptotic processGO:04352410.8BDNF, HTT, DNAJC5
7NAD biosynthetic processGO:00943510.8KMO, QPRT
8cellular response to organic substanceGO:07131010.8CALB1, CASP1
9apoptotic signaling pathwayGO:09719010.6HIP1, CASP2, CASP8

Molecular functions related to Huntington's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.3PFN1, SETD2, CASP1, CASP8, CALB1, CASP2
2cysteine-type endopeptidase activityGO:00419710.8CASP2, CASP8, CASP1
3ATP-dependent protein bindingGO:04300810.5DNAJC5, PRNP

Products for genes affiliated with Huntington's Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Huntington's Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet