Aliases & Classifications for Hydrarthrosis

Aliases & Descriptions for Hydrarthrosis:

Name: Hydrarthrosis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:528
ICD9CM 35 719.08
SNOMED-CT 64 156579009 202370001
UMLS 69 C0158157

Summaries for Hydrarthrosis

MalaCards based summary : Hydrarthrosis is related to intermittent hydrarthrosis and cascade stomach, and has symptoms including arthralgia, edema and metatarsalgia. An important gene associated with Hydrarthrosis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Infliximab and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Hydrarthrosis

Diseases related to Hydrarthrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
id Related Disease Score Top Affiliating Genes
1 intermittent hydrarthrosis 12.3
2 cascade stomach 10.2 AQP1 AQP3
3 prediabetes syndrome 10.2 AQP1 AQP3
4 cocaine dependence 10.2 IL1RN SLCO2A1
5 oligoarticular juvenile idiopathic arthritis with anti-nuclear antibodies 10.2 MEFV TNFRSF1A
6 spondylocostal dysostosis-hypospadias-intellectual disability syndrome 10.2 MEFV TNFRSF1A
7 candidiasis, familial, 4, autosomal recessive 10.2 MEFV TNFRSF1A
8 cyclotropia 10.2 C4A MEFV
9 malignant perineurioma 10.2 MEFV TNFRSF1A
10 muckle-wells syndrome 10.2 MEFV TNFRSF1A
11 mechanical lagophthalmos 10.2 MEFV TNFRSF1A
12 cutaneous sclerosis 10.2 IL1RN IL6
13 shoulder impingement syndrome 10.1 IL1RN IL6
14 labyrinthine bilateral reactive loss 10.1 C4A IL6
15 dermatomycosis 10.1 C4A MEFV
16 immunodeficiency 9 10.1 IL1RN TNFRSF1A
17 bazex syndrome 10.1 IL1RN TNFRSF1A
18 lepromatous leprosy 10.1 C4A IL6
19 pasteurellosis 10.1 IL6 MMP3
20 benign neonatal seizures 10.1 IL1RN IL6 MEFV
21 gonococcal endophthalmia 10.1 IL1RN IL6 MEFV
22 myiasis 10.1 IL1RN IL6 MEFV
23 mental retardation, autosomal dominant 22 10.1 IL1RN MEFV TNFRSF1A
24 dextrocardia 10.0 IL1RN IL6
25 keratoconus 10.0 IL1RN IL6 MMP3
26 synovium cancer 10.0 IL1RN IL6 MMP3
27 pancreas lymphoma 10.0 IL6 MEFV TNFRSF1A
28 stomatitis 10.0 IL1RN IL6
29 histiocytosis 10.0 IL1RN IL6 MMP3
30 cinca syndrome 10.0 MEFV TNFRSF1A
31 celiac disease 10.0 IL1RN MMP3 TNFRSF1A
32 esotropia 9.9 IL6 MEFV PRTN3
33 synovitis 9.9
34 patau syndrome 9.9 MEFV PRTN3 TNFRSF1A
35 primrose syndrome 9.9 IL1RN TNFRSF1A
36 arthritis 9.7
37 osteoarthritis 9.7
38 acute cervicitis 9.7
39 multicentric reticulohistiocytosis 9.7
40 cervicitis 9.7
41 goodpasture syndrome 9.7 C4A IL1RN IL6 MEFV TNFRSF1A
42 bone angioendothelial sarcoma 9.7 IL1RN IL6 MMP3 PRTN3
43 rheumatoid arthritis 9.5 IL1RN IL6 MMP3 PRTN3 TNFRSF1A
44 kidney leiomyosarcoma 8.5 AQP1 AQP3 AQP9 C4A ENSG00000250424 IL1RN

Graphical network of the top 20 diseases related to Hydrarthrosis:



Diseases related to Hydrarthrosis

Symptoms & Phenotypes for Hydrarthrosis

UMLS symptoms related to Hydrarthrosis:


arthralgia, edema, metatarsalgia, joint swelling, effusion of joint, other specified sites, other symptoms referable to joint, painful swollen joints, stiffness of joint, not elsewhere classified in icd10cm

MGI Mouse Phenotypes related to Hydrarthrosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 AQP1 AQP9 IL1RN IL6 MEFV MMP3
2 homeostasis/metabolism MP:0005376 9.81 AQP1 AQP3 AQP9 IL1RN IL6 MEFV
3 immune system MP:0005387 9.56 IL1RN IL6 MEFV MMP3 PRTN3 TNFRSF1A
4 skeleton MP:0005390 9.17 AQP1 AQP3 IL1RN IL6 MEFV MMP3

Drugs & Therapeutics for Hydrarthrosis

Drugs for Hydrarthrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
5
Liraglutide Approved Phase 4 204656-20-2
6
Glucosamine Approved, Nutraceutical Phase 4 3416-24-8 439213
7 Antiemetics Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Antineoplastic Agents, Hormonal Phase 4
10 Antirheumatic Agents Phase 4,Phase 3
11 Autonomic Agents Phase 4
12 Dermatologic Agents Phase 4,Phase 3
13 Gastrointestinal Agents Phase 4
14 glucocorticoids Phase 4
15 Hormone Antagonists Phase 4
16 Hormones Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Methylprednisolone acetate Phase 4
19 Methylprednisolone Hemisuccinate Phase 4
20 Neuroprotective Agents Phase 4
21 Peripheral Nervous System Agents Phase 4
22 Prednisolone acetate Phase 4
23 Prednisolone hemisuccinate Phase 4
24 Prednisolone phosphate Phase 4
25 Protective Agents Phase 4
26 Analgesics Phase 4
27 Analgesics, Non-Narcotic Phase 4
28 Anti-Inflammatory Agents, Non-Steroidal Phase 4
29 Cyclooxygenase 2 Inhibitors Phase 4
30 Cyclooxygenase Inhibitors Phase 4
31 Hypoglycemic Agents Phase 4
32 Incretins Phase 4
33
Chondroitin Nutraceutical Phase 4 9007-27-6 53477707
34
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
35
Cholecalciferol Approved, Nutraceutical Phase 3 67-97-0 6221 10883523 5280795
36
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
39 Bone Density Conservation Agents Phase 3
40 Ergocalciferols Phase 3
41 Micronutrients Phase 3
42 Trace Elements Phase 3
43 vitamin d Phase 3
44 Vitamins Phase 3
45 Antimetabolites Phase 3
46 Antimetabolites, Antineoplastic Phase 3
47 Folic Acid Antagonists Phase 3
48 Immunosuppressive Agents Phase 3
49 Nucleic Acid Synthesis Inhibitors Phase 3
50 Vitamin B Complex Phase 3

Interventional clinical trials:

(show all 22)
id Name Status NCT ID Phase
1 Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab Completed NCT01144143 Phase 4
2 Study on Efficacy and Safety of Chondroitin Sulfate + Glucosamine Hydrochloride Versus Celecoxib in Knee Osteoarthritis Completed NCT01425853 Phase 4
3 Ultrasound of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance Recruiting NCT02931383 Phase 4
4 VItamin D Effect on Osteoarthritis Study Completed NCT01176344 Phase 3
5 Ultrasound as Imaging Biomarker of Early Response to Tocilizumab and Methotrexate in Very Early Rheumatoid Arthritis Recruiting NCT02837146 Phase 3
6 Study to Evaluate the Efficacy and Safety of Intra-articular DA-5202 in Patients With Osteoarthritis of the Knee Recruiting NCT02554240 Phase 2
7 Somatosensory Stimulation in Knee Osteoarthritis Not yet recruiting NCT02854176 Phase 2
8 Magnetic Resonance (MR) Spectroscopy In Familial Mediterranean Fever (FMF) Patients Unknown status NCT00658060
9 Determination of Adipocytokine in Synovial Fluid of Osteoarthritis Patients Unknown status NCT01993342
10 The Effects of Joint Effusion on Proprioception Completed NCT01060215
11 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
12 Effects of Joint Effusion on Quadriceps Muscle Completed NCT01314820
13 MRI and Ultrasound Findings in Patients With Gout and Normal Plain Radiographs Completed NCT00584311
14 Joint Ultrasound Evaluation of Asymptomatic Rheumatic Feet Completed NCT01677416
15 Ultrasonography Assessment of Septic Arthritis on Native Joint Completed NCT02018952
16 Association Between Clinical Signs and MRI Findings of the Lumbar Facet Joints Completed NCT01628939
17 An Observational Study on RoActemra/Actemra (Tocilizumab) in Clinical Practice in Patients With Rheumatoid Arthritis (TRUST) Completed NCT01394276
18 Effect of Whole Body Vibration Therapy in Children With Juvenile Idiopathic Arthritis Completed NCT00836394
19 Ultrasound of the Knee in Obese Patients With Knee Osteoarthritis; Weight Loss Recruiting NCT02931370
20 Outcome Study of Highly-cross Linked Polyethylene vs. Standard Polyethylene for Primary Posterior Stabilized (PS) Total Knee Enrolling by invitation NCT02178020
21 Chikungunya Arthritis in the Americas Not yet recruiting NCT02463968
22 Efficacy and Safety of b-2Cool on Adults With Joint Discomfort Not yet recruiting NCT02843620

Search NIH Clinical Center for Hydrarthrosis

Genetic Tests for Hydrarthrosis

Anatomical Context for Hydrarthrosis

MalaCards organs/tissues related to Hydrarthrosis:

39
Bone

Publications for Hydrarthrosis

Articles related to Hydrarthrosis:

(show all 38)
id Title Authors Year
1
Boiogito, a Kampo medicine, improves hydrarthrosis in a rat model of knee osteoarthritis. ( 26703073 )
2015
2
Successful Treatment of Intermittent Hydrarthrosis With Hydroxychloroquine. ( 26587859 )
2015
3
Pathological findings from synovium of early osteoarthritic knee joints with persistent hydrarthrosis. ( 24837400 )
2014
4
Anakinra for a refractory case of intermittent hydrarthrosis with a TRAPS-related gene mutation. ( 22887853 )
2013
5
May some cases of intermittent hydrarthrosis represent an atypical form of calcium pyrophosphate dihydrate crystal deposition disease? Usefulness of mutational analysis of the MEFV gene. ( 17889261 )
2008
6
Association of intermittent hydrarthrosis with MEFV gene mutations. ( 16802374 )
2006
7
Successful therapy with low-dose colchicine in intermittent hydrarthrosis. ( 12595650 )
2003
8
Multicentric reticulohistiocytosis with hydrarthrosis in both knee joints: disease stabilization with synovectomy, and medication with a steroid and low-dose methotrexate. ( 24383904 )
2002
9
Analysis of synovial fluid components of hydrarthrosis in long-term hemodialysis patients. ( 10370156 )
1999
10
Comparison between clinical evaluation and ultrasonography in detecting hydrarthrosis of the knee. ( 10606382 )
1999
11
Intermittent hydrarthrosis. ( 11273267 )
1998
12
Hydrarthrosis of the knee or ankle revealing metaphyseal stress fractures of the tibia. A report of 3 cases. ( 8523370 )
1995
13
Hyaluronan, cartilage destruction and hydrarthrosis in traumatic arthritis. ( 11548232 )
1994
14
The treatment of idiopathic and secondary hydrarthrosis of the knee by intra-articular Rifamycin SV. ( 2098221 )
1990
15
Participation of synovial mast cells in intermittent hydrarthrosis. ( 2467680 )
1989
16
Treatment of hydrarthrosis of the knee with manual manipulation and herbs. ( 3246884 )
1988
17
Calcium pyrophosphate crystals in intermittent hydrarthrosis. ( 3029370 )
1986
18
LE cells in intermittent hydrarthrosis. ( 6157396 )
1980
19
Periodic synoviosis (intermittent hydrarthrosis) with observations and studies on a patient. ( 4464498 )
1974
20
Tarsal hydrarthrosis in the horse: response to intra-articular injection of synthetic steroids. ( 5815590 )
1969
21
Evaluation of intra-articular injection of synthetic steroids in tarsal hydrarthrosis in cattle. ( 5691642 )
1968
22
Tarsal hydrarthrosis (bog spavin) in the horse: blood, serum, and synovial fluid findings. ( 5688981 )
1968
23
Intra-articular injection of 6 alpha-methyl, 17 alpha-hydroxyprogesterone acetate in tarsal hydrarthrosis (bog spavin) in the horse. ( 5624181 )
1967
24
Therapeutic management of tarsal hydrarthrosis (bog spavin) in the horse by intra-articular injection of prednisolone. ( 6068578 )
1967
25
Characteristics of blood, serum, and synovial effusions in cattle with tarsal hydrarthrosis. ( 6069486 )
1967
26
Acute Cervical Hydrarthrosis. ( 19790510 )
1964
27
SYPHILITIC HYDRARTHROSIS. ( 14075738 )
1963
28
Intermittent hydrarthrosis; periodic benign synovitis. ( 13567199 )
1958
29
Intermittent hydrarthrosis. ( 13383213 )
1957
30
Periodic benign synovitis; idiopathic intermittent hydrarthrosis. ( 13367081 )
1956
31
Hodgkin's disease presenting as hydrarthrosis of knee. ( 14378634 )
1955
32
Intermittent hydrarthrosis. ( 14372871 )
1955
33
Intermittent hydrarthrosis. ( 14933539 )
1952
34
Intermittent hydrarthrosis; two cases. ( 15390577 )
1949
35
The roentgenographic appearance of temporomandibular hydrarthrosis. ( 21018447 )
1946
36
Idiopathic Hydrarthrosis. ( 19988486 )
1932
37
Intermittent Hydrarthrosis: (Hydrops Intermittens Articulorum). ( 21433466 )
1930
38
Chronic Hydrarthrosis. ( 19976537 )
1913

Variations for Hydrarthrosis

Expression for Hydrarthrosis

Search GEO for disease gene expression data for Hydrarthrosis.

Pathways for Hydrarthrosis

GO Terms for Hydrarthrosis

Cellular components related to Hydrarthrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.81 AQP1 AQP3 AQP9 C4A ENSG00000250424 IL1RN
2 extracellular space GO:0005615 9.43 C4A IL1RN IL6 MMP3 PRTN3 TNFRSF1A
3 basolateral plasma membrane GO:0016323 8.92 AQP1 AQP3 AQP9 ENSG00000250424

Biological processes related to Hydrarthrosis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.76 AQP9 IL1RN IL6 TNFRSF1A
2 inflammatory response GO:0006954 9.55 C4A IL1RN IL6 MEFV TNFRSF1A
3 excretion GO:0007588 9.52 AQP3 AQP9
4 cellular response to dexamethasone stimulus GO:0071549 9.51 AQP1 IL6
5 odontogenesis GO:0042476 9.49 AQP1 AQP3
6 renal water homeostasis GO:0003091 9.48 AQP1 AQP3
7 cellular response to nitric oxide GO:0071732 9.43 AQP1 MMP3
8 ammonium transmembrane transport GO:0072488 9.4 AQP1 ENSG00000250424
9 renal water absorption GO:0070295 9.37 AQP1 AQP3
10 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.32 IL1RN IL6
11 carbon dioxide transmembrane transport GO:0035378 9.26 AQP1 ENSG00000250424
12 glycerol transport GO:0015793 9.13 AQP1 AQP3 AQP9
13 water transport GO:0006833 8.92 AQP1 AQP3 AQP9 ENSG00000250424

Molecular functions related to Hydrarthrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ammonium transmembrane transporter activity GO:0008519 9.32 AQP1 ENSG00000250424
2 water transmembrane transporter activity GO:0005372 9.26 AQP1 AQP9
3 glycerol channel activity GO:0015254 9.16 AQP3 AQP9
4 carbon dioxide transmembrane transporter activity GO:0035379 8.96 AQP1 ENSG00000250424
5 water channel activity GO:0015250 8.92 AQP1 AQP3 AQP9 ENSG00000250424

Sources for Hydrarthrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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