Aliases & Classifications for Hydrarthrosis

MalaCards integrated aliases for Hydrarthrosis:

Name: Hydrarthrosis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:528
ICD9CM 34 719.08
SNOMED-CT 64 156579009 202370001

Summaries for Hydrarthrosis

MalaCards based summary : Hydrarthrosis is related to synovitis and arthritis, and has symptoms including stiffness of joint, not elsewhere classified in icd10cm, painful swollen joints and other symptoms referable to joint. An important gene associated with Hydrarthrosis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Development Endothelin-1/EDNRA signaling. The drugs Infliximab and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Hydrarthrosis

Diseases related to Hydrarthrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 synovitis 29.6 IL1B IL1RN IL6 MMP3
2 arthritis 29.3 IL1B IL1RN IL6 MMP3
3 intermittent hydrarthrosis 12.4
4 systemic onset juvenile idiopathic arthritis 10.4 IL1B MEFV
5 periostitis 10.4 IL1RN SLCO2A1
6 cervical adenitis 10.3 IL1B MEFV
7 frozen shoulder 10.3 ASIC2 ASIC3 MMP3
8 familial cold autoinflammatory syndrome 1 10.3 IL1B MEFV
9 vulvar vestibulitis syndrome 10.3 IL1B IL1RN
10 gastric cancer, hereditary diffuse 10.3 IL1B IL1RN
11 cinca syndrome 10.2 IL1B IL1RN MEFV
12 schnitzler syndrome 10.2 IL1B IL1RN
13 recurrent corneal erosion 10.2 IL1B IL6
14 cryopyrin-associated periodic syndrome 10.2 IL1RN IL6
15 familial mediterranean fever 10.2 IL1B IL1RN MEFV
16 bagassosis 10.2 IL1B IL6
17 acute cholangitis 10.2 IL1RN IL6
18 periodontitis, chronic 10.2 IL1B IL6
19 hypersensitivity reaction type iii disease 10.1 C4A IL6 MEFV
20 brucellosis 10.1 IL1RN IL6 MEFV
21 palindromic rheumatism 10.1 IL1B MEFV PRTN3
22 pericarditis 10.1 IL1B IL6 MEFV
23 leptospirosis 10.1 AQP1 IL1B IL6
24 primary bacterial infectious disease 10.1 IL1B IL6 MEFV
25 brain edema 10.0 AQP1 IL1B IL6
26 uremic pruritus 10.0 IL1B IL6
27 gastroschisis 10.0 IL1B IL6 MMP3
28 funisitis 10.0 IL1B IL6
29 osteosclerotic myeloma 10.0 IL1B IL1RN IL6
30 dengue shock syndrome 10.0 IL1B IL1RN IL6
31 cerebral artery occlusion 10.0 IL1B IL1RN
32 idiopathic neutropenia 10.0 IL1B IL1RN IL6
33 euthyroid sick syndrome 10.0 IL1B IL6
34 polyarteritis nodosa 10.0 IL6 MEFV PRTN3
35 aggressive periodontitis 10.0 IL1B IL1RN IL6
36 periodontitis 10.0 IL1B IL6 MMP3
37 autoinflammation, lipodystrophy, and dermatosis syndrome 10.0 IL1B IL1RN IL6
38 osteomyelitis 10.0 IL1B IL1RN IL6
39 anca-associated vasculitis 9.9 IL6 PRTN3
40 juvenile rheumatoid arthritis 9.9 IL1B IL1RN IL6
41 peritonitis 9.9 AQP1 IL1B IL6 MEFV
42 laryngitis 9.9 IL1B IL6
43 endometriosis 9.9 IL1B IL6 MMP3
44 glomerulonephritis 9.9 C4A IL1B PRTN3
45 adult-onset still's disease 9.8 IL1B IL1RN IL6 MEFV
46 aphthous stomatitis 9.8 IL1B IL1RN IL6 MEFV
47 osteoarthritis with mild chondrodysplasia 9.8
48 osteoarthritis 9.8
49 acute cervicitis 9.8
50 multicentric reticulohistiocytosis 9.8

Graphical network of the top 20 diseases related to Hydrarthrosis:



Diseases related to Hydrarthrosis

Symptoms & Phenotypes for Hydrarthrosis

UMLS symptoms related to Hydrarthrosis:


stiffness of joint, not elsewhere classified in icd10cm, painful swollen joints, other symptoms referable to joint, effusion of joint, other specified sites, metatarsalgia, edema, arthralgia

MGI Mouse Phenotypes related to Hydrarthrosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 SLCO2A1 AQP1 IL6 AQP3 MAPK3 AQP9
2 hematopoietic system MP:0005397 10.07 PRTN3 AQP1 IL6 MAPK3 AQP9 MEFV
3 immune system MP:0005387 9.96 PRTN3 PARP1 IL1RN IL6 AQP3 MAPK3
4 hearing/vestibular/ear MP:0005377 9.88 AQP1 AQP3 MAPK3 ASIC2 ASIC3 PARP1
5 integument MP:0010771 9.7 PARP1 IL1RN IL6 MAPK3 MEFV ASIC3
6 skeleton MP:0005390 9.56 IL1RN AQP1 IL6 AQP3 MAPK3 MEFV
7 vision/eye MP:0005391 9.17 PARP1 AQP1 IL6 AQP3 MAPK3 ASIC2

Drugs & Therapeutics for Hydrarthrosis

Drugs for Hydrarthrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
5
Liraglutide Approved Phase 4 204656-20-2 44147092
6
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
7 Antiemetics Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Antineoplastic Agents, Hormonal Phase 4
10 Antirheumatic Agents Phase 4,Phase 3
11 Autonomic Agents Phase 4
12 Dermatologic Agents Phase 4,Phase 3
13 Gastrointestinal Agents Phase 4
14 glucocorticoids Phase 4
15 Hormone Antagonists Phase 4
16 Hormones Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Methylprednisolone acetate Phase 4
19 Methylprednisolone Hemisuccinate Phase 4
20 Neuroprotective Agents Phase 4
21 Peripheral Nervous System Agents Phase 4
22 Prednisolone acetate Phase 4
23 Prednisolone hemisuccinate Phase 4
24 Prednisolone phosphate Phase 4
25 Protective Agents Phase 4
26 Analgesics Phase 4
27 Analgesics, Non-Narcotic Phase 4
28 Anti-Inflammatory Agents, Non-Steroidal Phase 4
29 Cyclooxygenase 2 Inhibitors Phase 4
30 Cyclooxygenase Inhibitors Phase 4
31 Hypoglycemic Agents Phase 4
32 Incretins Phase 4
33
Chondroitin Nutraceutical Phase 4 9007-27-6 53477707
34
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
35
Cholecalciferol Approved, Nutraceutical Phase 3 67-97-0 10883523 5280795 6221
36
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
37
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
38
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
39
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
40 Bone Density Conservation Agents Phase 3
41 Ergocalciferols Phase 3
42 Micronutrients Phase 3
43 Trace Elements Phase 3
44 Vitamins Phase 3
45 Antimetabolites Phase 3
46 Antimetabolites, Antineoplastic Phase 3
47 Folic Acid Antagonists Phase 3
48 Immunosuppressive Agents Phase 3
49 Nucleic Acid Synthesis Inhibitors Phase 3
50 Vitamin B Complex Phase 3

Interventional clinical trials:

(show all 25)

# Name Status NCT ID Phase Drugs
1 Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab Completed NCT01144143 Phase 4 Infliximab;Placebo;Standard of Care: Methylprednisolone acetate
2 Study on Efficacy and Safety of Chondroitin Sulfate + Glucosamine Hydrochloride Versus Celecoxib in Knee Osteoarthritis Completed NCT01425853 Phase 4 Chondroitin/Glucosamine (Droglican);Celecoxib
3 Ultrasound of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance Recruiting NCT02931383 Phase 4 Liraglutide 3 mg (Saxenda);Liraglutide 3 mg placebo
4 VItamin D Effect on Osteoarthritis Study Completed NCT01176344 Phase 3 Vitamin D;Placebo
5 Ultrasound as Imaging Biomarker of Early Response to Tocilizumab and Methotrexate in Very Early Rheumatoid Arthritis Recruiting NCT02837146 Phase 3 Methotrexate (MTX)
6 Study to Evaluate the Efficacy and Safety of Intra-articular DA-5202 in Patients With Osteoarthritis of the Knee Unknown status NCT02554240 Phase 2 DA-5202 20mg;DA-5202 10mg;Na Hyaluronate 20mg
7 Somatosensory Stimulation in Knee Osteoarthritis Not yet recruiting NCT02854176 Phase 2
8 Magnetic Resonance (MR) Spectroscopy In Familial Mediterranean Fever (FMF) Patients Unknown status NCT00658060
9 Determination of Adipocytokine in Synovial Fluid of Osteoarthritis Patients Unknown status NCT01993342
10 The Effects of Joint Effusion on Proprioception Completed NCT01060215
11 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
12 Effects of Joint Effusion on Quadriceps Muscle Completed NCT01314820
13 MRI and Ultrasound Findings in Patients With Gout and Normal Plain Radiographs Completed NCT00584311
14 Chikungunya Arthritis in the Americas Completed NCT02463968
15 Joint Ultrasound Evaluation of Asymptomatic Rheumatic Feet Completed NCT01677416
16 Ultrasonography Assessment of Septic Arthritis on Native Joint Completed NCT02018952
17 Association Between Clinical Signs and MRI Findings of the Lumbar Facet Joints Completed NCT01628939
18 Time Difference Between Onsets of Lateral And Medial Hamstring Muscles During Gait in Patients With Patellofemoral Pain. Completed NCT03392688
19 An Observational Study on RoActemra/Actemra (Tocilizumab) in Clinical Practice in Patients With Rheumatoid Arthritis (TRUST) Completed NCT01394276
20 Effect of Whole Body Vibration Therapy in Children With Juvenile Idiopathic Arthritis Completed NCT00836394
21 Ultrasound Guided Versus Landmark Guided Small & Medium Joint Arthrocentesis Recruiting NCT03327584
22 Pilot Trial to Assess the Feasibility of Implementing Objective Parameters in Patients Affected by Knee Osteoarthritis Recruiting NCT03421054
23 Ultrasound of the Knee in Obese Patients With Knee Osteoarthritis; Weight Loss Recruiting NCT02931370
24 Outcome Study of Highly-cross Linked Polyethylene vs. Standard Polyethylene for Primary Posterior Stabilized (PS) Total Knee Enrolling by invitation NCT02178020
25 Efficacy and Safety of b-2Cool on Adults With Joint Discomfort Not yet recruiting NCT02843620

Search NIH Clinical Center for Hydrarthrosis

Genetic Tests for Hydrarthrosis

Anatomical Context for Hydrarthrosis

MalaCards organs/tissues related to Hydrarthrosis:

38
Bone

Publications for Hydrarthrosis

Articles related to Hydrarthrosis:

(show all 38)
# Title Authors Year
1
Successful Treatment of Intermittent Hydrarthrosis With Hydroxychloroquine. ( 26587859 )
2015
2
Boiogito, a Kampo medicine, improves hydrarthrosis in a rat model of knee osteoarthritis. ( 26703073 )
2015
3
Pathological findings from synovium of early osteoarthritic knee joints with persistent hydrarthrosis. ( 24837400 )
2014
4
Anakinra for a refractory case of intermittent hydrarthrosis with a TRAPS-related gene mutation. ( 22887853 )
2013
5
May some cases of intermittent hydrarthrosis represent an atypical form of calcium pyrophosphate dihydrate crystal deposition disease? Usefulness of mutational analysis of the MEFV gene. ( 17889261 )
2008
6
Association of intermittent hydrarthrosis with MEFV gene mutations. ( 16802374 )
2006
7
Successful therapy with low-dose colchicine in intermittent hydrarthrosis. ( 12595650 )
2003
8
Multicentric reticulohistiocytosis with hydrarthrosis in both knee joints: disease stabilization with synovectomy, and medication with a steroid and low-dose methotrexate. ( 24383904 )
2002
9
Analysis of synovial fluid components of hydrarthrosis in long-term hemodialysis patients. ( 10370156 )
1999
10
Comparison between clinical evaluation and ultrasonography in detecting hydrarthrosis of the knee. ( 10606382 )
1999
11
Intermittent hydrarthrosis. ( 11273267 )
1998
12
Hydrarthrosis of the knee or ankle revealing metaphyseal stress fractures of the tibia. A report of 3 cases. ( 8523370 )
1995
13
Hyaluronan, cartilage destruction and hydrarthrosis in traumatic arthritis. ( 11548232 )
1994
14
The treatment of idiopathic and secondary hydrarthrosis of the knee by intra-articular Rifamycin SV. ( 2098221 )
1990
15
Participation of synovial mast cells in intermittent hydrarthrosis. ( 2467680 )
1989
16
Treatment of hydrarthrosis of the knee with manual manipulation and herbs. ( 3246884 )
1988
17
Calcium pyrophosphate crystals in intermittent hydrarthrosis. ( 3029370 )
1986
18
LE cells in intermittent hydrarthrosis. ( 6157396 )
1980
19
Periodic synoviosis (intermittent hydrarthrosis) with observations and studies on a patient. ( 4464498 )
1974
20
Tarsal hydrarthrosis in the horse: response to intra-articular injection of synthetic steroids. ( 5815590 )
1969
21
Tarsal hydrarthrosis (bog spavin) in the horse: blood, serum, and synovial fluid findings. ( 5688981 )
1968
22
Evaluation of intra-articular injection of synthetic steroids in tarsal hydrarthrosis in cattle. ( 5691642 )
1968
23
Characteristics of blood, serum, and synovial effusions in cattle with tarsal hydrarthrosis. ( 6069486 )
1967
24
Therapeutic management of tarsal hydrarthrosis (bog spavin) in the horse by intra-articular injection of prednisolone. ( 6068578 )
1967
25
Intra-articular injection of 6 alpha-methyl, 17 alpha-hydroxyprogesterone acetate in tarsal hydrarthrosis (bog spavin) in the horse. ( 5624181 )
1967
26
Acute Cervical Hydrarthrosis. ( 19790510 )
1964
27
SYPHILITIC HYDRARTHROSIS. ( 14075738 )
1963
28
Intermittent hydrarthrosis; periodic benign synovitis. ( 13567199 )
1958
29
Intermittent hydrarthrosis. ( 13383213 )
1957
30
Periodic benign synovitis; idiopathic intermittent hydrarthrosis. ( 13367081 )
1956
31
Hodgkin's disease presenting as hydrarthrosis of knee. ( 14378634 )
1955
32
Intermittent hydrarthrosis. ( 14372871 )
1955
33
Intermittent hydrarthrosis. ( 14933539 )
1952
34
Intermittent hydrarthrosis; two cases. ( 15390577 )
1949
35
The roentgenographic appearance of temporomandibular hydrarthrosis. ( 21018447 )
1946
36
Idiopathic Hydrarthrosis. ( 19988486 )
1932
37
Intermittent Hydrarthrosis: (Hydrops Intermittens Articulorum). ( 21433466 )
1930
38
Chronic Hydrarthrosis. ( 19976537 )
1913

Variations for Hydrarthrosis

Expression for Hydrarthrosis

Search GEO for disease gene expression data for Hydrarthrosis.

Pathways for Hydrarthrosis

Pathways related to Hydrarthrosis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 IL1B IL1RN IL6 MAPK3 MEFV
2
Show member pathways
12.42 ASIC2 ASIC3 IL1B MAPK3 PARP1
3
Show member pathways
12.09 IL1B IL6 MAPK3 MMP3
4 11.88 C4A IL1B IL1RN IL6
5 11.78 IL1B IL6 MMP3
6 11.7 IL1B IL6 MAPK3
7 11.64 AQP1 IL1B IL6 MAPK3
8 11.63 IL1B IL6 MMP3
9 11.59 IL1B IL6 MAPK3
10 11.49 IL1B IL6 MAPK3 MMP3
11 11.27 IL1B IL1RN IL6
12 11.14 C4A IL1B IL6 MAPK3
13 11.04 IL1B IL6 MAPK3
14
Show member pathways
10.72 IL1B IL6 MAPK3 MMP3
15 10.59 IL1B IL6

GO Terms for Hydrarthrosis

Cellular components related to Hydrarthrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 8.92 AQP1 AQP3 AQP9 ENSG00000250424

Biological processes related to Hydrarthrosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.95 AQP1 AQP3 AQP9 ENSG00000250424 SLCO2A1
2 inflammatory response GO:0006954 9.77 C4A IL1B IL1RN IL6 MEFV
3 cellular response to mechanical stimulus GO:0071260 9.67 AQP1 IL1B MAPK3
4 cation transmembrane transport GO:0098655 9.65 AQP1 ASIC2 ASIC3
5 positive regulation of histone acetylation GO:0035066 9.56 IL1B MAPK3
6 cellular response to nitric oxide GO:0071732 9.54 AQP1 MMP3
7 ammonium transmembrane transport GO:0072488 9.52 AQP1 ENSG00000250424
8 response to acidic pH GO:0010447 9.51 ASIC2 ASIC3
9 positive regulation of histone phosphorylation GO:0033129 9.46 IL1B MAPK3
10 sensory perception of sour taste GO:0050915 9.43 ASIC2 ASIC3
11 fever generation GO:0001660 9.4 IL1B IL1RN
12 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.32 IL1RN IL6
13 detection of mechanical stimulus involved in sensory perception GO:0050974 9.26 ASIC2 ASIC3
14 carbon dioxide transmembrane transport GO:0035378 9.16 AQP1 ENSG00000250424
15 glycerol transport GO:0015793 9.13 AQP1 AQP3 AQP9
16 water transport GO:0006833 8.92 AQP1 AQP3 AQP9 ENSG00000250424

Molecular functions related to Hydrarthrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.46 IL1B IL1RN
2 ligand-gated sodium channel activity GO:0015280 9.43 ASIC2 ASIC3
3 ammonium transmembrane transporter activity GO:0008519 9.4 AQP1 ENSG00000250424
4 water transmembrane transporter activity GO:0005372 9.37 AQP1 AQP9
5 glycerol channel activity GO:0015254 9.32 AQP3 AQP9
6 acid-sensing ion channel activity GO:0044736 9.26 ASIC2 ASIC3
7 channel activity GO:0015267 9.26 AQP1 AQP3 AQP9 ENSG00000250424
8 carbon dioxide transmembrane transporter activity GO:0035379 9.16 AQP1 ENSG00000250424
9 water channel activity GO:0015250 8.92 AQP1 AQP3 AQP9 ENSG00000250424

Sources for Hydrarthrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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